Search

Your search keyword '"Haïk, Stephane"' showing total 30 results
Start Over Author "Haïk, Stephane"
30 results on '"Haïk, Stephane"'

3. Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Author

Jones, Emma, Hummerich, Holger, Viré, Emmanuelle, Uphill, James, Dimitriadis, Athanasios, Speedy, Helen, Campbell, Tracy, Norsworthy, Penny, Quinn, Liam, Whitfield, Jerome, Linehan, Jacqueline, Jaunmuktane, Zane, Brandner, Sebastian, Jat, Parmjit, Nihat, Akin, How Mok, Tze, Ahmed, Parvin, Collins, Steven, Stehmann, Christiane, Sarros, Shannon, Kovacs, Gabor G, Geschwind, Michael D, Golubjatnikov, Aili, Frontzek, Karl, Budka, Herbert, Aguzzi, Adriano, Karamujić-Čomić, Hata, van der Lee, Sven J, Ibrahim-Verbaas, Carla A, van Duijn, Cornelia M, Sikorska, Beata, Golanska, Ewa, Liberski, Pawel P, Calero, Miguel, Calero, Olga, Sanchez-Juan, Pascual, Salas, Antonio, Martinón-Torres, Federico, Bouaziz-Amar, Elodie, Haïk, Stéphane, Laplanche, Jean-Louis, Brandel, Jean-Phillipe, Amouyel, Phillipe, Lambert, Jean-Charles, Parchi, Piero, Bartoletti-Stella, Anna, Capellari, Sabina, Poleggi, Anna, Ladogana, Anna, Pocchiari, Maurizio, Aneli, Serena, Matullo, Giuseppe, Knight, Richard, Zafar, Saima, Zerr, Inga, Booth, Stephanie, Coulthart, Michael B, Jansen, Gerard H, Glisic, Katie, Blevins, Janis, Gambetti, Pierluigi, Safar, Jiri, Appleby, Brian, Collinge, John, and Mead, Simon

Published
2020
Full Text
View/download PDF

4. Potential human transmission of amyloid β pathology: surveillance and risks

Author

Lauwers, Elsa, Lalli, Giovanna, Brandner, Sebastian, Collinge, John, Compernolle, Veerle, Duyckaerts, Charles, Edgren, Gustaf, Haïk, Stéphane, Hardy, John, Helmy, Adel, Ivinson, Adrian J, Jaunmuktane, Zane, Jucker, Mathias, Knight, Richard, Lemmens, Robin, Lin, I-Chun, Love, Seth, Mead, Simon, Perry, V Hugh, Pickett, James, Poppy, Guy, Radford, Sheena E, Rousseau, Frederic, Routledge, Carol, Schiavo, Giampietro, Schymkowitz, Joost, Selkoe, Dennis J, Smith, Colin, Thal, Dietmar R, Theys, Tom, Tiberghien, Pierre, van den Burg, Peter, Vandekerckhove, Philippe, Walton, Clare, Zaaijer, Hans L, Zetterberg, Henrik, and De Strooper, Bart

Published
2020
Full Text
View/download PDF

9. Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial

Author

Haïk, Stéphane, Marcon, Gabriella, Mallet, Alain, Tettamanti, Mauro, Welaratne, Arlette, Giaccone, Giorgio, Azimi, Shohreh, Pietrini, Vladimiro, Fabreguettes, Jean-Roch, Imperiale, Daniele, Cesaro, Pierre, Buffa, Carlo, Aucan, Christophe, Lucca, Ugo, Peckeu, Laurène, Suardi, Silvia, Tranchant, Christine, Zerr, Inga, Houillier, Caroline, Redaelli, Veronica, Vespignani, Hervé, Campanella, Angela, Sellal, François, Krasnianski, Anna, Seilhean, Danielle, Heinemann, Uta, Sedel, Frédéric, Canovi, Mara, Gobbi, Marco, Di Fede, Giuseppe, Laplanche, Jean-Louis, Pocchiari, Maurizio, Salmona, Mario, Forloni, Gianluigi, Brandel, Jean-Philippe, and Tagliavini, Fabrizio

Published
2014
Full Text
View/download PDF

10. New Ratios for the Detection and Classification of CJD in Multisequence MRI of the Brain

Author

Linguraru, Marius George, Ayache, Nicholas, Ballester, Miguel Ángel González, Bardinet, Eric, Galanaud, Damien, Haïk, Stéphane, Faucheux, Baptiste, Cozzone, Patrick, Dormont, Didier, Brandel, Jean-Philippe, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Duncan, James S., editor, and Gerig, Guido, editor

Published
2005
Full Text
View/download PDF

18. Variant Creutzfeldt-Jakob Disease Diagnosed 7.5 Years after Occupational Exposure.

Author

Vlaicu, M. Bustuchina, Haïk, Stephane, Brandel, Jean-Philippe, Culeux, Audrey, Belondrade, Maxime, Bougard, Daisy, Grznarova, Katarina, Denouel, Angeline, Plu, Isabelle, Bouaziz-Amar, Elodie, Seilhean, Danielle, Levasseur, Michèle, and Haïk, Stéphane

Subjects
*CREUTZFELDT-Jakob disease, *BOVINE spongiform encephalopathy, *COVID-19 pandemic, *INFLAMMATORY bowel diseases, *STANDARD & Poor's 500 Index
Abstract

The article presents a case study about the variant Creutzfeldt-Jakob disease (CJD), plausibly related to accidental occupational exposure who diagnosed 7.5 Years after occupational exposure. It discusses that Magnetic resonance imaging showed an increased FLAIR signal in pulvinar and dorsomedial nuclei of thalami.

Published
2020
Full Text
View/download PDF

19. Prions lacking glycosylated PrP at the first N-glycosylation site in both variably protease-sensitive prionopathy and a familial prion disease

Author

Xiao, Xiangzhu, Yuan, Jue, Haïk, Stephane, Cali, Ignazio, Li, Baiya, Laplanche, Jean-Louis, Moudjou, Mohammed, Laude, Hubert, Gambetti, Pierluigi, Kong, Qingzhong, Brandel, Jean-Philippe, Petersen, Robert B., Zou, Wen-Quan, Case Western Reserve University [Cleveland], Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Unité de recherche Neuroépidémiologie [CHU Pitié-Salpêtrière], Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and National Institutes of Health (NIH) NS062787, NIH AG-08012, AG-14359, the CJD Foundation, Alliance BioSecure, the University Center on Aging and Health with the support of the McGregor Foundation and the President’s Discretionary Fund (CWRU) as well as CDC Contract UR8/CCU515004

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

21. Automated Analysis of Basal Ganglia Intensity Distribution in Multisequence MRI of the Brain - Application to Creutzfeldt-Jakob Disease

Author

Linguraru, Marius George, González Ballester, Miguel Ángel, Bardinet, Eric, Galanaud, Damien, Haïk, Stephane, Faucheux, Baptiste, Hauw, Jean Jaques, Cozzone, Patrick J, Dormont, Didier, Brandel, Jean-Philippe, Ayache, Nicholas, Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and INRIA

Subjects
NEW-VARIANT CJD, MULTISEQUENCE MRI, [INFO.INFO-OH]Computer Science [cs]/Other [cs.OH], SEGMENTATION, CREUTZFELDT-JAKOB DISEASE, IMAGE NORMALISATION, BRAIN MRI, nervous system diseases, INTERNAL NUCLEI, GREY MATTER, mental disorders, HUMAN VISUAL SYSTEM MODEL, SPORADIC CJD, IMAGE REGISTRATION
Abstract

We present a method for the analysis of basal ganglia (including the thalamus) for accurate detection of human spongiform encephalopathy in multisequence MRI of the brain. One common feature of most forms of prion protein infections is the appearance of hyperintensities in the deep grey matter area of the brain in T2-weighted MR images. We employ T1, T2 and Flair-T2 MR sequences for the detection of intensity deviations in the internal nuclei. First, the MR data is registered to a probabilistic atlas and normalised in intensity. Then smoothing is applied with edge enhancement. The segmentation of hyperintensities is performed using a model of the human visual system. For more accurate results, a priori anatomical data from a segmented atlas is employed to refine the registration and remove false positives. The results are robust over the patient data and in accordance to the clinical ground truth. Our method further allows the quantification of intensity distributions in basal ganglia. The caudate nuclei are highlighted as main areas of diagnosis of sporadic Creutzfeldt-Jakob Disease (CJD), in agreement with the histological data. The algorithm permitted to classify the intensities of abnormal signals in sporadic CJD patient FLAIR images with a more significant hypersignal in caudate nuclei (10/10) and putamen (6/10) than in thalami. Using normalised measures of the intensity relations between the internal grey nuclei of patients, we robustly differentiate sporadic CJD and new-variant CJD patients, as a first attempt towards an automatic classification tool of human spongiform encephalopathies.

Published
2004

22. Rapidly Progressive Alzheimer's Disease: A Multicenter Update

Author

Schmidt, Christian, primary, Haïk, Stephane, additional, Satoh, Katsuya, additional, Rábano, Alberto, additional, Martinez-Martin, Pablo, additional, Roeber, Sigrun, additional, Brandel, Jean-Philippe, additional, Calero-Lara, Miguel, additional, de Pedro-Cuesta, Jesús, additional, Laplanche, Jean-Louis, additional, Hauw, Jean-Jaques, additional, Kretzschmar, Hans, additional, and Zerr, Inga, additional

Published
2012
Full Text
View/download PDF

27. Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans.

Author

Bizat, Nicolas, Peyrin, Jean-Michel, Haïk, Stephane, Cochois, Véronique, Beaudry, Patrick, Laplanche, Jean-Louis, and Néri, Christian

Subjects
PRIONS, NEUROTOXICOLOGY, PHENOTYPES, GENETIC mutation, NEURONS, PROTEINASES
Abstract

Although prion propagation is well understood, the signaling pathways activated by neurotoxic forms of prion protein (PrP) and those able to mitigate pathological phenotypes remain largely unknown. Here, we identify src-2, a Fyn-related kinase, as a gene required for human PrP with an insertional mutation to be neurotoxic in Caenorhabditis elegans, and the longevity modulator sir-2.1/SIRT1, a sirtuin deacetylase, as a modifier of prion neurotoxicity. The expression of octarepeat-expanded PrP in C. elegans mechanosensory neurons led to a progressive loss of response to touch without causing cell death, whereas wild-type PrP expression did not alter behavior. Transgenic PrP molecules showed expression at the plasma membrane, with protein clusters, partial resistance to proteinase K (PK), and protein insolubility detected for mutant PrP. Loss of function (LOF) of src-2 greatly reduced mutant PrP neurotoxicity without reducing PKresistant PrP levels. Increased sir-2.1 dosage reversed mutant PrP neurotoxicity, whereas sir-2.1 LOF showed aggravation, and these effects did not alter PK-resistant PrP. Resveratrol, a polyphenol known to act through sirtuins for neuroprotection, reversed mutant PrP neurotoxicity in a sir-2.1-dependent manner. Additionally, resveratrol reversed cell death caused by mutant PrP in cerebellar granule neurons from prnp-null mice. These results suggest that Fyn mediates mutant PrP neurotoxicity in addition to its role in cellular PrP signaling and reveal that sirtuin activation mitigates these neurotoxic effects. Sirtuin activators may thus have therapeutic potential to protect from prion neurotoxicity and its effects on intracellular signaling. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results