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1. HXB/Ipcv and BXH/Cub recombinant inbred strains of the rat: strain distribution patterns of 632 alleles

Author

Michal Pravenec, Kren V, Krenová D, Bíla V, Zídek V, Simáková M, Musilová A, Ha, Lith, and Lf, Zutphen

Subjects
Genetic Markers, Recombination, Genetic, Species Specificity, Cardiovascular Diseases, Risk Factors, Rats, Inbred BN, Rats, Inbred SHR, Animals, Genetic Predisposition to Disease, Rats, Inbred Strains, Alleles, Rats
Abstract

The HXB/Ipcv and BXH/Cub sets of recombinant inbred (RI) strains were derived from the spontaneously hypertensive rats (SHR/OlaIpcv) and normotensive Brown Norway (BN-Lx/Cub) rats. The RI strains were produced as a model system for genetic and correlation analysis of spontaneous hypertension and other risk factors of cardiovascular disease such as insulin resistance and dyslipidemia. The RI strains were phenotyped in multiple hemodynamic and metabolic traits. In the current study, we describe strain distribution patterns of 632 genetic markers.

Published
2000

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