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178 results on '"Ha, Ki-Chan"'

4. Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Author

Baek, Hyang-Im, Ha, Ki-Chan, Park, Yu-Kyung, Kim, Tae-Young, and Park, Soo-Jung

Abstract

Sprout ginseng extract (ThinkGIN™) manufactured through a smart farm system has been shown to improve memory in preclinical studies. This study conducted a 12-week randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of ThinkGIN™ for improving memory in subjective memory impairment (SMI). Subjects aged 55 to 75 years with SMI participated in this study. A total of 80 subjects who met the inclusion/exclusion criteria were assigned to the ThinkGIN™ group (n = 40, 450 mg ThinkGIN™/day) or a placebo group (n = 40). Efficacy and safety evaluations were conducted before intervention and at 12 weeks after intervention. As a result of 12 weeks of ThinkGIN™ intake, significant differences in SVLT, RCFT, MoCA-K, PSQI-K, and AChE were observed between the two groups. Safety evaluation (AEs, laboratory tests, vital signs, and electrocardiogram) revealed that ThinkGIN™ was safe with no clinically significant changes. Therefore, ThinkGIN™ has the potential to be used as a functional food to improve memory. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population

Author

Cho, Jung Min, primary, Yoo, Dokyeong, additional, Lee, Jeong-Yong, additional, Oh, Mi-Sun, additional, Ha, Ki-Chan, additional, Baek, Hyang-Im, additional, Lee, Seung-Min, additional, Lee, Jong Ho, additional, and Yoo, Hye Jin, additional

Published
2021
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23. Effects of Porphyra tenera Supplementation on the Immune System: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Author

Jung, Su-Jin, Jang, Hui-Yeon, Jung, Eun-Soo, Noh, Soon-Ok, Shin, Sang-Wook, Ha, Ki-Chan, Baek, Hyang-Im, Ahn, Byung-Jae, Oh, Tae-Hwan, and Chae, Soo-Wan

Subjects
nutrition
Abstract

Objective: The purpose of this study was to determine if Porphyra tenera extract (PTE) has immune-enhancing effects and is safe in healthy adults. Methods: Subjects (3x103 ≤ peripheral blood leukocyte levels < 8x103 cells/μl) who met the inclusion criteria were recruited for this study. Enrolled subjects (n=120) were randomly assigned to either the PTE group (n=60) who were given 2.5 g/day of PTE (as Porphyra tenera extract) in capsule form or the placebo group (n=60) who were given crystal cellulose capsules with the identical appearance, weight, and flavor as the PTE capsules for 8 weeks. Outcomes were assessed by measuring natural killer cell (NK-cell) activity, cytokines, and upper respiratory infection (URI), and safety parameters were assessed at baseline and 8 weeks. Results: Compared to baseline, NK cell activity (%) increased for all effector cell to target cell ratios in the PTE group after 8 weeks, but there were no changes in the placebo group (p

Published
2020

24. Additional file 1 of The cholesterol-lowering effect of unripe Rubus coreanus is associated with decreased oxidized LDL and apolipoprotein B levels in subjects with borderline-high cholesterol levels: a randomized controlled trial

Author

Cho, Jung Min, Jisuk Chae, Jeong, Sa Rang, Moon, Min Jung, Ha, Ki-Chan, Sunoh Kim, and Lee, Jong Ho

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1: Supplementary Table 1. Lipid-related parameters of placebo and test group at baseline and 12-week follow up. Supplementary Table 2. Hematology and biochemical parameters of placebo and test group at baseline and 12-week follow up. Supplementary Figure 1. Relationship among changed levels of total cholesterol, non-HDL-cholesterol, LDL-cholesterol and apolipoprotein B, and oxidized-LDL. Supplementary Figure 2. Relationship and distribution of hs-CRP, LDL cholesterol and oxidized LDL levels in each group at baseline and follow-up.

Published
2020
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30. The Effects of Aronia Extract on Body Weight and Body Fat: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Author

Ha, Ki Chan, primary, Park, Yu Kyung, additional, Baek, Hyang Im, additional, Kim, Hye Mi, additional, Kim, Young Mi, additional, Jeong, Da Young, additional, Shin, Sang Wook, additional, Bae, Jung Shik, additional, An, Ji Hye, additional, Jeon, Yeon Jeong, additional, Park, Ji Eun, additional, and Kwon, Young Dal, additional

Published
2020
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32. A placebo-controlled trial of Korean red ginseng extract for preventing Influenza-like illness in healthy adults

Author

Ha Ki-Chan, Kim Min-Gul, Oh Mi-Ra, Choi Eun-Kyung, Back Hyang-Im, Kim Sun-Young, Park Eun-Ok, Kwon Dae-Young, Yang Hye-Jeong, Kim Min-Jeong, Kang Hee-Joo, Lee Ju-Hyung, Choi Kyung-Min, Chae Soo-Wan, and Lee Chang-Seop

Subjects
Other systems of medicine, RZ201-999
Abstract

Abstracts Background Standardized Korean red ginseng extract has become the best-selling influenza-like illness (ILI) remedy in Korea, yet much controversy regarding the efficacy of the Korean red ginseng (KRG) in reducing ILI incidence remains. The aim of the study is to assess the efficacy of the KRG extract on the ILI incidence in healthy adults. Methods/Design We will conduct a randomized, double-blind, placebo-controlled study at the onset of the influenza seasons. A total of 100 subjects 30-70 years of age will be recruited from the general populations. The subjects will be instructed to take 9 capsules per day of either the KRG extract or a placebo for a period of 3 months. The primary outcome measure is to assess the frequency of ILI onset in participated subjects. Secondary variable measures will be included severity and duration of ILI symptoms. The ILI symptoms will be scored by subjects using a 4-point scale. Discussion This study is a randomized placebo controlled trial to evaluate the efficacy of the KRG extract compared to placebo and will be provided valuable new information about the clinical and physiological effects of the KRG extract on reduction of ILI incidence including flu and upper respiratory tract infections. The study has been pragmatically designed to ensure that the study findings can be implemented into clinical practice if KRG extract can be shown to be an effective reduction strategy in ILI incidence. Trial Registration NCT01478009.

Published
2012
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33. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

Author

Park, Soo-Hyun, primary, Jung, Su-Jin, additional, Choi, Eun-Kyung, additional, Ha, Ki-Chan, additional, Baek, Hyang-Im, additional, Park, Yu-Kyung, additional, Han, Kap-Hoon, additional, Jeong, Soon-Yeon, additional, Oh, Jung-Hee, additional, Cha, Youn-Soo, additional, Park, Byung-Hyun, additional, and Chae, Soo-Wan, additional

Published
2019
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34. Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial

Author

Choi, Eun-Kyung, primary, Won, Yu Hui, additional, Kim, Soon-Young, additional, Noh, Soon-Ok, additional, Park, Soo-Hyun, additional, Jung, Su-Jin, additional, Lee, Chong Kil, additional, Hwang, Bang Yeon, additional, Lee, Myung Koo, additional, Ha, Ki-Chan, additional, Baek, Hyang-Im, additional, Kim, Hye-Mi, additional, Ko, Myoung-Hwan, additional, and Chae, Soo-Wan, additional

Published
2019
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36. Influence of the Chungkookjang on histamine-induced wheal and flare skin response: a randomized, double-blind, placebo controlled trial

Author

Kwon Dae-Young, Yang Hye-Jeong, Kim Min-Jeong, Kang Hee-Joo, Kim Hyun-Jin, Ha Ki-Chan, Back Hyang-Im, Kim Sun-Young, Park Eun-Ok, Kim Min-Gul, Yun Seok-Kwon, Chae Soo-Wan, and Cho Back-Hwan

Subjects
Other systems of medicine, RZ201-999
Abstract

Abstracts Background Allergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, urticaria, allergic rhinitis, asthma and allergic dermatitis. The development of food products for the prevention of allergic disease is an important subject in human health. The chungkookjang (CKJ) has been reported to exhibit antiallergic inflammatory activity. Therefore, the aim of the study is to examine the effects of the CKJ to reduce histamine-induced wheal and flare skin responses. Methods/Design A randomized, double-blind, placebo-controlled study in 60 healthy subjects will be carried out. Sixty volunteers (aged 20-80) who gave a written consent before entering the study will be randomized in two groups of thirty subjects each. The skin prick test with histamine solution of 10 mg/ml will be performed on the ventral forearm, 10 cm from the elbow. The subjects will be instructed to take 35 g per day of either the CKJ pills or a placebo pills for a period of 3 months. Diameters of wheal and flare will be assessing 15 minutes after performing the above-mentioned skin prick test. The primary outcome is change in wheal and flare responses. Secondary outcomes will be include change in serum histamine, immunoglobulin E, cytokines (interferon-gamma, interleukin-4, -10, and tumor necrosis factor-alpha), and eosinophil cationic protein. Discussion This study will show the potential anti-inflammatory properties of the CKJ in their skin activity when histamine is the challenging agent as occurs in the clinical situation. And the present protocol will confirm the efficacy and safety of the CKJ for allergy symptoms, suggesting more basic knowledge to conduct further randomized controlled trials (RCT). If this study will be successfully performed, the CKJ will be an alternative dietary supplemental remedy for allergy patients. Trial Registration NCT01402141

Published
2011
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42. Effectiveness of Hizikia fusiformis Extract on Erosive Gastritis: A 4-week, Randomized, Double-blind and Placebo-controlled Trial

Author

Baek, Hyang-Im, primary, Kim, Sang-Wook, additional, Ha, Ki-Chan, additional, Kim, Hye-Mi, additional, So, Byung-Ok, additional, Choi, Eun-Kyung, additional, Park, Eun-Ock, additional, Jeon, Byung-Jun, additional, Park, Byung-Hyun, additional, Nam, Taek-Jeong, additional, Kim, In-Hye, additional, and Chae, Soo-Wan, additional

Published
2015
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47. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial

Author

Oh, Mi-Ra, primary, Park, Soo-Hyun, additional, Kim, Sun-Young, additional, Back, Hyang-Im, additional, Kim, Min-Gul, additional, Jeon, Ji-Young, additional, Ha, Ki-Chan, additional, Na, Won-Taek, additional, Cha, Youn-Soo, additional, Park, Byung-Hyun, additional, Park, Tae-sun, additional, and Chae, Soo-Wan, additional

Published
2014
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