8 results on '"Ha, Jeslin Chian Hung"'
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2. Single-cell landscape of idiopathic multicentric Castleman disease in identical twins
- Author
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Chan, Jason Yongsheng, primary, Loh, Jui Wan, additional, Lim, Jing Quan, additional, Liany, Herty, additional, Lee, Elizabeth Chun Yong, additional, Lee, Jing Yi, additional, Kannan, Bavani, additional, Lim, Boon Yee, additional, Guo, Zexi, additional, Lim, Kerry, additional, Ha, Jeslin Chian Hung, additional, Ng, Cedric Chuan-Young, additional, Ko, Tun Kiat, additional, Huang, Dachuan, additional, Seow, Dominique Yuan Bin, additional, Cheng, Chee Leong, additional, Chan, Sock Hoai, additional, Ngeow, Joanne, additional, Teh, Bin Tean, additional, Lim, Soon Thye, additional, and Ong, Choon Kiat, additional
- Published
- 2024
- Full Text
- View/download PDF
3. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
- Author
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Au, Wing-Yan, Chiu, Brian, Fan, Lei, Li, Zheng, LAM, Tai Hing, Liang, Raymond, Yeh, Su-Peng, Xu, Jun, Ip, Dennis Kai Ming, Li, Gandi, Xu, Gang, Wang, Xiaodong, Bai, Ou, Cai, Qing-Qing, Xia, Yi, Chen, Jie-Rong, Luo, Chun-Ling, Xiong, Xiang-Yu, Zeng, Yanni, Wei, Pan-Pan, Liu, Chu-Jun, Liu, Yu-Xiang, Cao, Yu-Lu, He, Shuai, Liu, Yang, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Kee, Rebecca Xiangpin, Tan, Jing, Liu, Yanhui, Zhang, Fen, Feng, Yanfen, Rao, Huilan, Chng, Wee Joo, Chan, Jason Yong Sheng, Somasundaram, Nagavalli D/O, Tao, Miriam, Ras, Mohamad Farid Bin Harunal, Yeoh, Kheng-Wei, Goh, Yeow Tee, Ong, Shin Yeu, Grigoropoulos, Nicholas Francis, Wong, Esther Kam Yin, Pang, Jane Wan Lu, Lim, Jing Quan, Chia, Burton Kuan Hui, Kim, Seok Jin, Yoon, Sang Eun, Choi, Seungkyu, Kuo, Ching-Yuan, Chen, Tsai-Yun, Su, Yu-Chieh, Huang, Wen-Tsung, Lee, Ming-Yang, Yao, Wenxiu, Ngan, Kai-Cheong, Liu, Herman, Lee, Harold, Yip, Sze-Fai, Liu, Jie, Li, Jianyong, Rabkin, Charles S., Berndt, Sonja, Bassig, Bryan, Hu, Wei, Zhao, Mingfeng, Li, Yuming, Zhai, Qiongli, Shao, Zonghong, Qiu, Lugui, Wang, Jianxiang, Xu, Fu-Ping, Chen, Ling, Hou, Yu, Xu, Shuangnian, Huang, Zhen, Xie, Mingling, Li, Ming, Zhong, Shilong, Zhang, Yan, Gu, Dongqing, Wang, Xin, Foo, Jia Nee, Li, Zhiqiang, Dai, Juncheng, Sun, Liangdan, Wang, Zhenzhen, Liu, Hong, Zhou, Hui, Sun, Yonghu, Koh, Woon-Puay, Heng, Chew-Kiat, Hong, Chew Soo, Ahn, Jeeyun, Park, Kyu Hyung, Tin, Aung, Gu, Jieruo, Xia, Xiaojun, Li, Bo, Yu, Xueqing, Lin, Guo-Wang, Xu, Caigang, Chen, Kexin, Huang, Hui-Qiang, Chen, Jieping, Song, Bao, Chan, John K C, Li, Wenyu, Liu, Weiping, Shih, Lee-Yung, Chuang, Wen-Yu, Kim, Won Seog, Tan, Wen, Peng, Rou-Jun, Laurensia, Yurike, Cheah, Daryl Ming Zhe, Huang, DaChuan, Cheng, Chee Leong, Su, Yi-Jiun, Tan, Soo-Yong, Ng, Siok-Bian, Tang, Tiffany Pooi Ling, Han, Kyudong, Wang, Vivien Ya-Fan, Jia, Wei-Hua, Pei, Zhong, Li, Ya-Jun, Gao, Song, Shi, Yongyong, Hu, Zhibin, Zhang, Furen, Zhang, Ben, Zeng, Yi-Xin, Shen, Hongbing, He, Lin, Ong, Choon Kiat, Lim, Soon Thye, Chanock, Stephen, Kwong, Yok-Lam, Lin, Dongxin, Rothman, Nathaniel, Khor, Chiea Chuen, Lan, Qing, and Bei, Jin-Xin
- Published
- 2020
- Full Text
- View/download PDF
4. Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma
- Author
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Lim, Jing Quan, Huang, Dachuan, Tang, Tiffany, Tan, Daryl, Laurensia, Yurike, Peng, Rou-Jun, Wong, Esther Kam Yin, Cheah, Daryl Ming Zhe, Chia, Burton Kuan Hui, Iqbal, Jabed, Grigoropoulos, Nicholas Francis, Nairismägi, Maarja-Liisa, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Hong, Huangming, Kim, Seok Jin, Cho, Junhun, Tse, Eric, Mow, Benjamin, Cai, Qi-Chun, Poon, Li-Mei, Cai, Qing-qing, Tan, Jing, Chan, Jason Yongsheng, Lim, Johnathan Xiande, Goh, Yeow Tee, Phipps, Colin, Rötzschke, Olaf, Cheng, Chee Leong, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Loh, Yvonne Su Ming, Au-Yeung, Rex, Chan, Thomas Sau-Yan, Kwong, Yok-Lam, Hwang, William, Kim, Won Seog, Bei, Jin-Xin, Lin, Tongyu, Ong, Choon Kiat, and Lim, Soon Thye
- Published
- 2020
- Full Text
- View/download PDF
5. Correction to: Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma
- Author
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Lim, Jing Quan, Huang, Dachuan, Tang, Tiffany, Tan, Daryl, Laurensia, Yurike, Peng, Rou-Jun, Wong, Esther Kam Yin, Cheah, Daryl Ming Zhe, Chia, Burton Kuan Hui, Iqbal, Jabed, Grigoropoulos, Nicholas Francis, Nairismägi, Maarja-Liisa, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Hong, Huangming, Kim, Seok Jin, Cho, Junhun, Tse, Eric, Mow, Benjamin, Cai, Qi-Chun, Poon, Li-Mei, Cai, Qing-qing, Tan, Jing, Chan, Jason Yongsheng, Lim, Johnathan Xiande, Goh, Yeow Tee, Phipps, Colin, Rötzschke, Olaf, Cheng, Chee Leong, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Loh, Yvonne Su Ming, Au-Yeung, Rex, Chan, Thomas Sau-Yan, Kwong, Yok-Lam, Hwang, William, Kim, Won Seog, Bei, Jin-Xin, Lin, Tongyu, Ong, Choon Kiat, and Lim, Soon Thye
- Published
- 2021
- Full Text
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6. A genomic‐augmented multivariate prognostic model for the survival of natural‐killer/T‐cell lymphoma patients from an international cohort
- Author
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Lim, Jing Quan, primary, Huang, Dachuan, additional, Chan, Jason Yongsheng, additional, Laurensia, Yurike, additional, Wong, Esther Kam Yin, additional, Cheah, Daryl Ming Zhe, additional, Chia, Burton Kuan Hui, additional, Chuang, Wen‐Yu, additional, Kuo, Ming‐Chung, additional, Su, Yi‐Jiun, additional, Cai, Qing‐qing, additional, Feng, Yanfen, additional, Rao, Huilan, additional, Feng, Li‐Na, additional, Wei, Pan‐Pan, additional, Chen, Jie‐Rong, additional, Han, Bo‐Wei, additional, Lin, Guo‐Wang, additional, Cai, Jun, additional, Fang, Yu, additional, Tan, Jing, additional, Hong, Huangming, additional, Liu, Yanhui, additional, Zhang, Fen, additional, Li, Wenyu, additional, Poon, Michelle L. M., additional, Ng, Siok‐Bian, additional, Jeyasekharan, Anand, additional, Ha, Jeslin Chian Hung, additional, Khoo, Lay Poh, additional, Chin, Suk Teng, additional, Pang, Wan Lu, additional, Kee, Rebecca, additional, Cheng, Chee Leong, additional, Grigoropoulos, Nicholas Francis, additional, Tang, Tiffany, additional, Tao, Miriam, additional, Farid, Mohamad, additional, Puan, Kia Joo, additional, Xiong, Jie, additional, Zhao, Wei‐Li, additional, Khor, Chiea Chuen, additional, Hwang, William, additional, Kim, Won Seog, additional, Campo, Elias, additional, Tan, Patrick, additional, Teh, Bin Tean, additional, Chng, Wee‐Joo, additional, Rötzschke, Olaf, additional, Tousseyn, Thomas, additional, Huang, Hui‐Qiang, additional, Rozen, Steve, additional, Lim, Soon Thye, additional, Shih, Lee‐Yung, additional, Bei, Jin‐Xin, additional, and Ong, Choon Kiat, additional
- Published
- 2022
- Full Text
- View/download PDF
7. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
- Author
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Lin, Guo-Wang, primary, Xu, Caigang, additional, Chen, Kexin, additional, Huang, Hui-Qiang, additional, Chen, Jieping, additional, Song, Bao, additional, Chan, John K C, additional, Li, Wenyu, additional, Liu, Weiping, additional, Shih, Lee-Yung, additional, Chuang, Wen-Yu, additional, Kim, Won Seog, additional, Tan, Wen, additional, Peng, Rou-Jun, additional, Laurensia, Yurike, additional, Cheah, Daryl Ming Zhe, additional, Huang, DaChuan, additional, Cheng, Chee Leong, additional, Su, Yi-Jiun, additional, Tan, Soo-Yong, additional, Ng, Siok-Bian, additional, Tang, Tiffany Pooi Ling, additional, Han, Kyudong, additional, Wang, Vivien Ya-Fan, additional, Jia, Wei-Hua, additional, Pei, Zhong, additional, Li, Ya-Jun, additional, Gao, Song, additional, Shi, Yongyong, additional, Hu, Zhibin, additional, Zhang, Furen, additional, Zhang, Ben, additional, Zeng, Yi-Xin, additional, Shen, Hongbing, additional, He, Lin, additional, Ong, Choon Kiat, additional, Lim, Soon Thye, additional, Chanock, Stephen, additional, Kwong, Yok-Lam, additional, Lin, Dongxin, additional, Rothman, Nathaniel, additional, Khor, Chiea Chuen, additional, Lan, Qing, additional, Bei, Jin-Xin, additional, Au, Wing-Yan, additional, Chiu, Brian, additional, Fan, Lei, additional, Li, Zheng, additional, LAM, Tai Hing, additional, Liang, Raymond, additional, Yeh, Su-Peng, additional, Xu, Jun, additional, Ip, Dennis Kai Ming, additional, Li, Gandi, additional, Xu, Gang, additional, Wang, Xiaodong, additional, Bai, Ou, additional, Cai, Qing-Qing, additional, Xia, Yi, additional, Chen, Jie-Rong, additional, Luo, Chun-Ling, additional, Xiong, Xiang-Yu, additional, Zeng, Yanni, additional, Wei, Pan-Pan, additional, Liu, Chu-Jun, additional, Liu, Yu-Xiang, additional, Cao, Yu-Lu, additional, He, Shuai, additional, Liu, Yang, additional, Ha, Jeslin Chian Hung, additional, Khoo, Lay Poh, additional, Kee, Rebecca Xiangpin, additional, Tan, Jing, additional, Liu, Yanhui, additional, Zhang, Fen, additional, Feng, Yanfen, additional, Rao, Huilan, additional, Chng, Wee Joo, additional, Chan, Jason Yong Sheng, additional, Somasundaram, Nagavalli D/O, additional, Tao, Miriam, additional, Ras, Mohamad Farid Bin Harunal, additional, Yeoh, Kheng-Wei, additional, Goh, Yeow Tee, additional, Ong, Shin Yeu, additional, Grigoropoulos, Nicholas Francis, additional, Wong, Esther Kam Yin, additional, Pang, Jane Wan Lu, additional, Lim, Jing Quan, additional, Chia, Burton Kuan Hui, additional, Kim, Seok Jin, additional, Yoon, Sang Eun, additional, Choi, Seungkyu, additional, Kuo, Ching-Yuan, additional, Chen, Tsai-Yun, additional, Su, Yu-Chieh, additional, Huang, Wen-Tsung, additional, Lee, Ming-Yang, additional, Yao, Wenxiu, additional, Ngan, Kai-Cheong, additional, Liu, Herman, additional, Lee, Harold, additional, Yip, Sze-Fai, additional, Liu, Jie, additional, Li, Jianyong, additional, Rabkin, Charles S., additional, Berndt, Sonja, additional, Bassig, Bryan, additional, Hu, Wei, additional, Zhao, Mingfeng, additional, Li, Yuming, additional, Zhai, Qiongli, additional, Shao, Zonghong, additional, Qiu, Lugui, additional, Wang, Jianxiang, additional, Xu, Fu-Ping, additional, Chen, Ling, additional, Hou, Yu, additional, Xu, Shuangnian, additional, Huang, Zhen, additional, Xie, Mingling, additional, Li, Ming, additional, Zhong, Shilong, additional, Zhang, Yan, additional, Gu, Dongqing, additional, Wang, Xin, additional, Foo, Jia Nee, additional, Li, Zhiqiang, additional, Dai, Juncheng, additional, Sun, Liangdan, additional, Wang, Zhenzhen, additional, Liu, Hong, additional, Zhou, Hui, additional, Sun, Yonghu, additional, Koh, Woon-Puay, additional, Heng, Chew-Kiat, additional, Hong, Chew Soo, additional, Ahn, Jeeyun, additional, Park, Kyu Hyung, additional, Tin, Aung, additional, Gu, Jieruo, additional, Xia, Xiaojun, additional, Li, Bo, additional, and Yu, Xueqing, additional
- Published
- 2020
- Full Text
- View/download PDF
8. An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma
- Author
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Goh, Jasmine, De Mel, Sanjay, Hoppe, Michal M., Mohd Abdul Rashid, Masturah Bte, Zhang, Xi Yun, Jaynes, Patrick, Ka Yan Ng, Esther, Rahmat, Nur’Atiqa Diana Binti, Jayalakshmi, Liu, Clementine Xin, Poon, Limei, Chan, Esther, Lee, Joanne, Chee, Yen Lin, Koh, Liang Piu, Tan, Lip Kun, Soh, Teck Guan, Yuen, Yi Ching, Loi, Hoi-Yin, Ng, Siok-Bian, Goh, Xueying, Eu, Donovan, Loh, Stanley, Ng, Sheldon, Tan, Daryl, Cheah, Daryl Ming Zhe, Pang, Wan Lu, Huang, Dachuan, Ong, Shin Yeu, Nagarajan, Chandramouli, Chan, Jason Yongsheng, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Somasundaram, Nagavalli, Tang, Tiffany, Ong, Choon Kiat, Chng, Wee-Joo, Lim, Soon Thye, Chow, Edward K., and Jeyasekharan, Anand D.
- Abstract
Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin’s lymphoma (RR-NHL), combination treatment chosen for an individual patient is empirical, and response rates remain poor in individuals with chemotherapy-resistant disease. Here, we evaluate an experimental-analytic method, quadratic phenotypic optimization platform (QPOP), for prediction of patient-specific drug combination efficacy from a limited quantity of biopsied tumor samples. In this prospective study, we enrolled 71 patients with RR-NHL (39 B cell NHL and 32 NK/T cell NHL) with a median of two prior lines of treatment, at two academic hospitals in Singapore from November 2017 to August 2021. Fresh biopsies underwent ex vivo testing using a panel of 12 drugs with known efficacy against NHL to identify effective single and combination treatments. Individualized QPOP reports were generated for 67 of 75 patient samples, with a median turnaround time of 6 days from sample collection to report generation. Doublet drug combinations containing copanlisib or romidepsin were most effective against B cell NHL and NK/T cell NHL samples, respectively. Off-label QPOP-guided therapy offered at physician discretion in the absence of standard options (n= 17) resulted in five complete responses. Among patients with more than two prior lines of therapy, the rates of progressive disease were lower with QPOP-guided treatments than with conventional chemotherapy. Overall, this study shows that the identification of patient-specific drug combinations through ex vivo analysis was achievable for RR-NHL in a clinically applicable time frame. These data provide the basis for a prospective clinical trial evaluating ex vivo–guided combination therapy in RR-NHL.
- Published
- 2022
- Full Text
- View/download PDF
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