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Objective To investigate the value of 7.0T cardiac magnetic resonance tissue tracking imaging (CMR-TT) in evaluation of cardiac function in rats with early left ventricular remodeling induced by isoproterenol (ISO). Methods Eighteen male healthy specific pathogen-free (SPF) SD rats were randomly divided into control (n=6) and model group (n=12).The rat model of early left ventricular remodeling was established by subcutaneous multipoint injection of 10 mg·kg-1·d-1 ISO solution for 10 d.After modeling, 7.0T CMR cine sequence scans were performed immediately, and the post-processing software CVI42.0 was used to analyze and compare the differences in each left ventricular (LV) function and myocardial strain parameters between the 2 groups of rats.Enzyme-linked immunosorbent assay (ELISA) was performed to detect cardiac troponin Ⅰ(cTn-Ⅰ) and N-terminal B-type natriuretic peptide (NT-pro BNP) levels in right atrial transvenous serum.Pearson correlation analysis was employed to analyze the correlation of left ventricular ejection fraction (LVEF), cTn-Ⅰ and NT-pro BNP levels with each overall myocardial strain parameter of LV. Results The results of imaging, serology and pathology displayed that that the model group showed obvious hypertrophy of the LV myocardium and different damage at each base of the myocardium, resulting in a significant decrease in conventional cardiac function and myocardial strain parameters of LV, which was the symbol of myocardial contractile dysfunction.Compared with the control group, heart mass (HM), heart mass index (HMI), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular myocardial mass (LVM), left ventricular end-diastolic maximum wall thickness (LVEDTHmax), and left ventricular remodeling index (LVRI) were significantly greater in the rats of the model group (P < 0.05).LVEF, left ventricular global circumferential strain (LVGCS), left ventricular global radial strain (LVGRS), left ventricular global longitudinal strain (LVGLS), LVGRS-Mid-cavity, LVGRS-Apical, LVGCS-Mid-cavity, LVGCS-Apical, LVGLS-Basal, and LVGLS-Apical decreased in different degrees (P < 0.05).The changes in LVEF and cTn-Ⅰ and NT-pro BNP levels were all correlated with the changes in each overall LV myocardial strain parameter. Conclusion CMR-TT can be used to assess cardiac dysfunction in early left ventricular remodeling. x

Background: Epicardial adipose tissue (EAT) may have a paracrine effect on coronary microcirculation and myocardium. However, it is unclear whether EAT is linked to cardiac function and perfusion. Purpose: To investigate the association of EAT with left ventricular (LV) strain and myocardial perfusion in patients with coronary artery disease (CAD). Study Type: Retrospective. Population: A total of 78 patients with CAD and 20 healthy controls. The patients were further divided into high (n = 39) and low EAT volume (n = 39) groups according to median EAT volume. Field Strength/Sequence: A 1.5 T, balanced steady‐state free precession, inversion recovery prepared echo‐planar, and segmented‐turbo fast low‐angle shot (FLASH) phase‐sensitive inversion recovery (PSIR) sequences. Assessment: EAT volume was measured by manually tracing the epicardial border and the visceral layer of pericardium on the short‐axis cine stacks. LV strain parameters included global radial (GRS), circumferential (GCS), and longitudinal peak strain (GLS). Perfusion indices included upslope, perfusion index, time‐to‐maximum signal intensity (TTM), and maximum signal intensity (MaxSI). Statistical Tests: One‐way analysis of variance or Kruskal–Wallis rank tests, Chi‐squared or Fisher exact tests. Multivariate linear regression analyses. A P value < 0.05 was considered statistically significant. Results: The parameters of GRS GCS, GLS, upslope, perfusion index, and MaxSI were significantly lower in the patients when compared to the controls. Moreover, the high EAT volume group presented significantly longer TTM values and lower GRS, GCS, GLS, upslope, perfusion index, and MaxSI than the low EAT volume group. Multivariate linear regression analyses demonstrated that EAT was independently associated with GRS, GCS, GLS, upslope, perfusion index, TTM, and MaxSI in patients. EAT and upslope were independently associated with GRS, while EAT and perfusion index were both independently associated with GCS and GLS. Data Conclusion: EAT was associated with parameters of LV function and perfusion, and myocardial perfusion was independently associated with LV strain in patients with CAD. Evidence Level: 3. Technical Efficacy: Stage 3. [ABSTRACT FROM AUTHOR]