1. Human T-lymphotropic virus/HIV co-infection: a clinical review.
- Author
-
Dhasmana D and Taylor GP
- Subjects
- Anti-Retroviral Agents therapeutic use, CD4-Positive T-Lymphocytes immunology, Coinfection drug therapy, Coinfection immunology, HIV Infections drug therapy, HIV Infections immunology, HTLV-I Infections drug therapy, HTLV-I Infections immunology, HTLV-II Infections drug therapy, HTLV-II Infections immunology, Human T-lymphotropic virus 1, Human T-lymphotropic virus 2, Humans, HIV Infections complications, HTLV-I Infections complications, HTLV-II Infections complications
- Abstract
Purpose of Review: Human T-lymphotropic virus (HTLV)/HIV co-infections are often undiagnosed, with important clinical implications. The literature is relatively sparse with key observations derived in the pre-highly-active antiretroviral therapy era., Recent Findings: The epidemiology of co-infection, the impact of each virus on the other, with particular reference to clinical manifestations and the impact of antiretroviral therapy on HTLVs are described., Summary: Important clinical effects of HTLV/HIV co-infection include the higher rates of myelopathy and other neurological disorders and the poor predicative value of CD4+ cell counts as a surrogate for immune suppression. Current antiretroviral therapies in isolation have no proven effect on HTLV-1/2 proviral load.
- Published
- 2014
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