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23,973 results on '"HOWARD, R."'

2. La Silla-QUEST RR Lyrae Star Survey II: The Crater II Tidal Streams

Author

Coppi, P. S., Zinn, R., Baltay, C., Rabinowitz, D., Girard, T., Howard, R., Ment, K., and Rahman, R.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe photometry improvements in the La Silla--Quest RR Lyrae star (RRLS) survey that enable it to reach distances from the Sun ($d_{\odot}$) $\sim 140$ kpc. We report the results of surveying $\sim 300~ {\rm deg}^2$ of sky around the large, low-surface-brightness Crater II dwarf spheroidal galaxy. At $d_{\odot}$ $> 80$ kpc, we find a large overdensity of RRLS that extends beyond the traditional isophotal contours used for Crater II. The majority of these RRLS (34) have a linear distribution on the sky, extending over $15^{\circ}$, that runs through Crater II and is oriented along Crater II's proper motion vector. We hypothesize that this unlikely distribution traces extended tidal streams associated with Crater II. To test this, we search for other Crater II stellar populations that should be in the streams. Using Gaia proper motion data, we isolate $\approx$ 17 candidate stars outside of Crater II that are consistent with being luminous stars from the Crater II Red Giant Branch (RGB). Their spatial distribution is consistent with the RRLS one. The inferred streams are long, spanning a distance range $\sim 80 - 135$ kpc from the Galactic Centre. They are oriented at a relatively small angle relative to our line-of-sight ($\sim 25^{\circ}$), which means some stream stars are likely projected onto the main body of the galaxy. Comparing the numbers of RRLS and RGB candidate stars found in the streams to those in the main galaxy, we estimate Crater II has lost $\gtrsim 30\%$ of its stellar mass., Comment: 29 pages, 19 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society

Published
2024

3. A WISPR of the Venus Surface: Analysis of the Venus Nightside Thermal Emission at Optical Wavelengths

Author

Lustig-Yaeger, J., Izenberg, N. R., Gilmore, M. S., Mayorga, L. C., May, E. M., Vourlidas, A., Hess, P., Wood, B. E., Howard, R. A., Raouafi, N. E., and Arney, G. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Parker Solar Probe (PSP) conducted several flybys of Venus while using Venus' gravity for orbital adjustments to enable its daring passes of the Sun. During these flybys, PSP turned to image the nightside of Venus using the Wide-field Imager for Solar PRobe (WISPR) optical telescopes, which unexpectedly observed Venus' surface through its thick and cloudy atmosphere in a theorized, but until-then unobserved near-visible spectral window below 0.8 $\mu$m. We use observations taken during PSP's fourth Venus gravity assist flyby to examine the origin of the Venus nightside flux and confirm the presence of this new atmospheric window through which to observe the surface geology of Venus. The WISPR images are well explained by emission from the hot Venus surface escaping through a new atmospheric window in the optical with an overlying emission component from the atmosphere at the limb that is consistent with O$_2$ nightglow. The surface thermal emission correlates strongly with surface elevation (via temperature) and emission angle. Tessera and plains units have distinct WISPR brightness values. Controlling for elevation, Ovda Regio tessera is brighter than Thetis Regio; likewise, the volcanic plains of Sogolon Planitia are brighter than the surrounding regional plains units. WISPR brightness at 0.8 $\mu$m is predicted to be positively correlated to FeO content in minerals; thus, the brighter units may have a different starting composition, be less weathered, or have larger particle sizes., Comment: 12 pages, 10 figures, 2 tables. Published in PSJ

Published
2023
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4. Impact of lenalidomide-bortezomib-dexamethasone induction on patients with newly diagnosed multiple myeloma and renal impairment: Results from the Connect® MM Registry

Author

Ailawadhi, Sikander, Lee, Hans C., Omel, James, Toomey, Kathleen, Hardin, James W., Gasparetto, Cristina J., Jagannath, Sundar, Rifkin, Robert M., Durie, Brian G. M., Narang, Mohit, Terebelo, Howard R., Joshi, Prashant, Jou, Ying-Ming, Mouro, Jorge, Yu, Edward, and Abonour, Rafat

Published
2024
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5. Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing

Author

Leader, Amy E., Rebbeck, Timothy R., Oh, William K., Patel, Alpa V., Winer, Eric P., Bailey, LeeAnn O., Gomella, Leonard G., Lumpkins, Crystal Y., Garraway, Isla P., Aiello, Lisa B., Baskin, Monica L., Cheng, Heather H., Cooney, Kathleen A., Ganzak, Amanda, George, Daniel J., Halabi, Susan, Hathaway, Feighanne, Healy, Claire, Kim, Joseph W., Leapman, Michael S., Loeb, Stacy, Maxwell, Kara N., McNair, Christopher, Morgan, Todd M., Prindeville, Breanne, Soule, Howard R., Steward, Whitney L., Suttiratana, Sakinah C., Taplin, Mary-Ellen, Yamoah, Kosj, Fortune, Thierry, Bennett, Kris, Blanding-Godbolt, Joshua, Gross, Laura, and Giri, Veda N.

Published
2024
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6. Impact of lenalidomide-bortezomib-dexamethasone induction on patients with newly diagnosed multiple myeloma and renal impairment: Results from the Connect® MM Registry

Author

Sikander Ailawadhi, Hans C. Lee, James Omel, Kathleen Toomey, James W. Hardin, Cristina J. Gasparetto, Sundar Jagannath, Robert M. Rifkin, Brian G. M. Durie, Mohit Narang, Howard R. Terebelo, Prashant Joshi, Ying-Ming Jou, Jorge Mouro, Edward Yu, and Rafat Abonour

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Limited data exist on the effects of induction treatment in patients with newly diagnosed multiple myeloma (NDMM) and renal impairment (RI), who may also be ineligible for autologous stem cell transplant. This analysis investigated the impact of lenalidomide-bortezomib-dexamethasone (RVd) induction on renal function in patients from the Connect® MM Registry based on transplant status. Eligible patients were aged ≥18 years with symptomatic MM diagnosed ≤2 months before enrollment. Patients in this analysis received front-line RVd for ≥3 cycles and were grouped by transplant status and baseline renal function. As of August 4, 2021, 344 transplanted and 289 non-transplanted patients had received RVd for ≥3 cycles at induction. Improved renal function was observed at 3, 6, and 12 months in patients with all severities of RI at baseline. In patients with >60 and ≤60 creatinine clearance mL/min at baseline, median progression-free survival was 49.4 months and 47.6 months in transplanted patients and 35.7 months and 29.1 months in non-transplanted patients, respectively. These results provide real-world evidence that patients with NDMM and RI who receive front-line RVd for ≥3 cycles may have improved renal function regardless of transplant status, with renal function no longer affecting the long-term outcome. Clinical trial information: NCT01081028.

Published
2024
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9. Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing

Author

Amy E. Leader, Timothy R. Rebbeck, William K. Oh, Alpa V. Patel, Eric P. Winer, LeeAnn O. Bailey, Leonard G. Gomella, Crystal Y. Lumpkins, Isla P. Garraway, Lisa B. Aiello, Monica L. Baskin, Heather H. Cheng, Kathleen A. Cooney, Amanda Ganzak, Daniel J. George, Susan Halabi, Feighanne Hathaway, Claire Healy, Joseph W. Kim, Michael S. Leapman, Stacy Loeb, Kara N. Maxwell, Christopher McNair, Todd M. Morgan, Breanne Prindeville, Howard R. Soule, Whitney L. Steward, Sakinah C. Suttiratana, Mary-Ellen Taplin, Kosj Yamoah, Thierry Fortune, Kris Bennett, Joshua Blanding-Godbolt, Laura Gross, and Veda N. Giri

Subjects
Prostate cancer, Genetic testing, Disparities, Health equity, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Black men consistently have higher rates of prostate cancer (PCA)- related mortality. Advances in PCA treatment, screening, and hereditary cancer assessment center around germline testing (GT). Of concern is the significant under-engagement of Black males in PCA GT, limiting the benefit of precision therapy and tailored cancer screening despite longstanding awareness of these disparities. To address these critical disparities, the Socioecological Model (SEM) was employed to develop comprehensive recommendations to overcome barriers and implement equitable strategies to engage Black males in PCA GT. Methods Clinical/research experts, national organization leaders, and community stakeholders spanning multiple regions in US and Africa participated in developing a framework for equity in PCA GT grounded in the SEM. A novel mixed-methods approach was employed to generate key areas to be addressed and informed statements for consensus consideration utilizing the modified Delphi model. Statements achieving strong consensus (> =75% agreement) were included in final equity frameworks addressing clinical/community engagement and research engagement. Results All societal levels of the SEM (interpersonal, institutional, community, and policy/advocacy) must deliver information about PCA GT to Black males that address benefits/limitations, clinical impact, hereditary cancer implications, with acknowledgment of mistrust (mean scores [MS] 4.57-5.00). Interpersonal strategies for information delivery included engagement of family/friends/peers/Black role models to improve education/awareness and overcome mistrust (MS 4.65-5.00). Institutional strategies included diversifying clinical, research, and educational programs and integrating community liaisons into healthcare institutions (MS 4.57-5.00). Community strategies included partnerships with healthcare institutions and visibility of healthcare providers/researchers at community events (MS 4.65–4.91). Policy/advocacy included improving partnerships between advocacy and healthcare/community organizations while protecting patient benefits (MS 4.57-5.00). Media strategies were endorsed for the first time at every level (MS 4.56-5.00). Conclusion The SEM-based equity frameworks proposed provide the first multidisciplinary strategies dedicated to increase engagement of Black males in PCA GT, which are critical to reduce disparities in PCA-mortality through informing tailored screening, targeted therapy, and cascade testing in families.

Published
2024
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10. Parker Solar Probe: Four Years of Discoveries at Solar Cycle Minimum

Author

Raouafi, N. E., Matteini, L., Squire, J., Badman, S. T., Velli, M., Klein, K. G., Chen, C. H. K., Matthaeus, W. H., Szabo, A., Linton, M., Allen, R. C., Szalay, J. R., Bruno, R., Decker, R. B., Akhavan-Tafti, M., Agapitov, O. V., Bale, S. D., Bandyopadhyay, R., Battams, K., Berčič, L., Bourouaine, S., Bowen, T., Cattell, C., Chandran, B. D. G., Chhiber, R., Cohen, C. M. S., D'Amicis, R., Giacalone, J., Hess, P., Howard, R. A., Horbury, T. S., Jagarlamudi, V. K., Joyce, C. J., Kasper, J. C., Kinnison, J., Laker, R., Liewer, P., Malaspina, D. M., Mann, I., McComas, D. J., Niembro-Hernandez, T., Panasenco, O., Pokorný, P., Pusack, A., Pulupa, M., Perez, J. C., Riley, P., Rouillard, A. P., Shi, C., Stenborg, G., Tenerani, A., Verniero, J. L., Viall, N., Vourlidas, A., Wood, B. E., Woodham, L. D., and Woolley, T.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Plasma Physics, Physics - Space Physics
Abstract

Launched on 12 Aug. 2018, NASA's Parker Solar Probe had completed 13 of its scheduled 24 orbits around the Sun by Nov. 2022. The mission's primary science goal is to determine the structure and dynamics of the Sun's coronal magnetic field, understand how the solar corona and wind are heated and accelerated, and determine what processes accelerate energetic particles. Parker Solar Probe returned a treasure trove of science data that far exceeded quality, significance, and quantity expectations, leading to a significant number of discoveries reported in nearly 700 peer-reviewed publications. The first four years of the 7-year primary mission duration have been mostly during solar minimum conditions with few major solar events. Starting with orbit 8 (i.e., 28 Apr. 2021), Parker flew through the magnetically dominated corona, i.e., sub-Alfv\'enic solar wind, which is one of the mission's primary objectives. In this paper, we present an overview of the scientific advances made mainly during the first four years of the Parker Solar Probe mission, which go well beyond the three science objectives that are: (1) Trace the flow of energy that heats and accelerates the solar corona and solar wind; (2) Determine the structure and dynamics of the plasma and magnetic fields at the sources of the solar wind; and (3) Explore mechanisms that accelerate and transport energetic particles., Comment: 157 pages, 65 figures

Published
2023
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12. Activation of human STING by a molecular glue-like compound

Author

Li, Jie, Canham, Stephen M., Wu, Hua, Henault, Martin, Chen, Lihao, Liu, Guoxun, Chen, Yu, Yu, Gary, Miller, Howard R., Hornak, Viktor, Brittain, Scott M., Michaud, Gregory A., Tutter, Antonin, Broom, Wendy, Digan, Mary Ellen, McWhirter, Sarah M., Sivick, Kelsey E., Pham, Helen T., Chen, Christine H., Tria, George S., McKenna, Jeffery M., Schirle, Markus, Mao, Xiaohong, Nicholson, Thomas B., Wang, Yuan, Jenkins, Jeremy L., Jain, Rishi K., Tallarico, John A., Patel, Sejal J., Zheng, Lianxing, Ross, Nathan T., Cho, Charles Y., Zhang, Xuewu, Bai, Xiao-Chen, and Feng, Yan

Published
2024
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14. Contributors

Author

Abelson, Jennifer, primary, Aboutanos, Michel B., additional, Abraham, Peter J., additional, Abualruz, Abdul Rahman, additional, Agarwal, Suresh, additional, Agrawal, Devendra K., additional, Alverdy, John C., additional, Aly, Ahmed, additional, Amato, Stas, additional, Anstadt, Michael J., additional, Asensio, Juan A., additional, Avery, Martin, additional, Bailey, Jeffrey A., additional, Barie, Philip S., additional, Becker, Tyson, additional, Beckerman, Daniel, additional, Bedrick, Edward J., additional, Benson, Jamie, additional, Berne, John D., additional, Berry, Cherisse, additional, Berry, Stepheny, additional, Bhat, Sneha G., additional, Bowie, Jason M., additional, Bowyer, Mark W., additional, Bozeman, Matthew C., additional, Bradley, Matthew, additional, Brakenridge, Scott, additional, Brandes, Steven B., additional, Brenner, Megan, additional, Britt, L.D., additional, Brown, Carlos V., additional, Brown, Ian E., additional, Brown, J. Christian, additional, Brown, Tommy, additional, Buckman, Robert F., additional, Burlew, Clay Cothren, additional, Byers, Patricia M., additional, Caban, Kim M., additional, Cancio, Leopoldo C., additional, Cannon, Jeremy W., additional, Cantlie, Shawn M., additional, Carroll, Eben A., additional, Champion, Howard R., additional, Childs, Ed W., additional, Chiu, William C., additional, Christmas, A. Britton, additional, Cioffi, William G., additional, Cocanour, Christine S., additional, Cohen, Mitchell J., additional, Coimbra, Raul, additional, Cook, Alan, additional, Cornell, David L., additional, Cotton, Bryan A., additional, Couture, Daniel E., additional, Cox, Thomas B., additional, Cristancho, Luis Alfonso Bustamante, additional, Croce, Martin A., additional, Croft, Chasen A., additional, Cubano, Miguel A., additional, Dabestani, Parinaz J., additional, Danton, Gary H., additional, Davis, Christopher S., additional, Davis, Kimberly, additional, de Moya, Marc A., additional, Desai, Urmen, additional, Destiné, Henson, additional, Diebel, Lawrence N., additional, Doucet, Jay J., additional, DuBose, Joseph J., additional, Dubov, Wayne E., additional, Duchesne, Juan C., additional, Durham, Rodney M., additional, Durso, Anthony M., additional, Eastridge, Brian, additional, Efron, David T., additional, Efron, Philip A., additional, Elster, Eric, additional, Esposito, Thomas J., additional, Fakhry, Samir M., additional, Feliciano, David V., additional, Fernandez, Carlos, additional, Fernandez-Moure, Joseph S., additional, Fernández, Luis G., additional, Fiorentino, Michele, additional, Firstenberg, Michael S., additional, Flint, Lewis M., additional, Fredericks, Charles J., additional, Fry, Donald E., additional, Galán, Ricardo, additional, Galante, Joseph M., additional, Galvagno, Samuel M., additional, Garcia, Ana Maria, additional, García, Erwin Rodriguez, additional, García-Núñez, Col Luis Manuel, additional, Gentilello, Larry M., additional, Ghanta, Ravi K., additional, Gigena, Alejandro, additional, Gilani, Ramyar, additional, Glance, Laurent G., additional, Goldman, Matthew, additional, Gonzalez, Ernest A., additional, Gonzalez, Richard P., additional, Grabo, Daniel, additional, Gross, Ronald I., additional, Gummadi, Sriharsha, additional, Guerrero, Whitney M., additional, Gunter, Oliver L., additional, Gurney, Jennifer M., additional, Gutiérrez, Jorge A., additional, Hall, Chad, additional, Hauser, Carl J., additional, Henry, Sharon, additional, Hirshberg, Ashen, additional, Holcomb, John B., additional, Hosmer, David, additional, Hoth, J. Jason, additional, Gomez, Tatiana Hoyos, additional, Hoyt, David B., additional, Humphries, Ashley, additional, Iyengar, Rahul, additional, Jawa, Randeep S., additional, Jessie, Elliot, additional, Johannigman, Jay, additional, Aquino Jose, Victor M., additional, Jurkovich, Gregory J., additional, Kalamchi, Louay, additional, Kapil, Aditi M., additional, Karmy-Jones, Riyad, additional, Kasotakis, George, additional, Kelley, Kathryn C., additional, Keskey, Robert, additional, Kessler, John J., additional, Kim, Dennis Y., additional, Kiraly, Laszlo, additional, Kirton, Orlando C., additional, Kotaru, Tharun R., additional, Kunac, Anastasia, additional, Kwolek, Kinga, additional, Lallemand, Michael S., additional, Ledgerwood, Anna M., additional, Lee, Amanda, additional, Leeper, Christine M., additional, Li, Zhongyu, additional, Libby, Matthew, additional, Lim, Robert B., additional, Liveris, Anna, additional, Livingston, David H., additional, Lobb, Jennifer, additional, Loftus, Tyler J., additional, Lucas, Charles E., additional, Luchette, Fred A., additional, Lundeberg, Megan R., additional, Mackersie, Robert C., additional, Mackey, Kevin E., additional, Magnotti, Louis J., additional, Mah, John W., additional, Maldonado, William Sánchez, additional, Malhotra, Ajai K., additional, Malone, Debra L., additional, Marini, Corrado P., additional, Martin, Matthew J., additional, Marttos, Antonio C., additional, Martyak, Michael T., additional, Mathew, Prakash J., additional, Mattox, Kenneth L., additional, Mayberry, John C., additional, Mazzini, Federico N., additional, McNelis, John, additional, Meallet, Mario A., additional, Meerkov, Meir B.L., additional, Meizoso, Jonathan P., additional, Meredith, J. Wayne, additional, Michetti, Christopher P., additional, Miljkovic, Stephanie S., additional, Miller, Keith R., additional, Miller, Preston R., additional, Minei, Joseph P., additional, Mitchell, Frank L., additional, Moas, Victor M., additional, Mohr, Alicia M., additional, Molnar, Joseph A., additional, Moore, Ernest E., additional, Moore, Frederick A., additional, Moutinho, Manuel, additional, Moysidis, Stavros, additional, Munera, Felipe, additional, Naiditch, Jessica A., additional, Napolitano, Lena M., additional, Narayan, Mayur, additional, Nash, Nicholas A., additional, Nicholson, Kristina J., additional, Nicholson, Susannah, additional, Norwood, Scott H., additional, Nunn, Andrew M., additional, O’Shea, Anne, additional, Osler, Turner M., additional, Pachter, H. Leon, additional, Paladino, Lorenzo, additional, Panthaki, Zubin Jal, additional, Parikh, Manish, additional, Pasquale, Michael D., additional, Patel, Purvi P., additional, Peitzman, Andrew B., additional, Peralta, Ruben, additional, Perez-Alonso, Alejandro J., additional, Pestana, Ivo A., additional, Petrone, Patrizio, additional, Pierre, Edgar J., additional, Pilson, Holly, additional, Polk, Travis, additional, Puyana, Juan Carlos, additional, Quintana, David, additional, Rai, Vikrant, additional, Rajasingh, Charlotte, additional, Ranney, Stephen, additional, Reisbig, Mark D., additional, Reiser, Bibiana Jin, additional, Remick, Kyle N., additional, Rhee, Peter, additional, Rich, Norman M., additional, Richardson, J. David, additional, Richart, Charles M., additional, Rivas, Luis A., additional, Robles, Anamaria J., additional, Rodriguez, Aurelio, additional, Rosengart, Matthew, additional, Rosenthal, Martin D., additional, Rotondo, Michael F., additional, Rowe, Vincent L., additional, Rubano, Jerry A., additional, Rubiano, Andrés M., additional, Ruggero, John M., additional, Rushing, Amy, additional, Salim, Ali, additional, Saillant, Noelle Nugent, additional, Sally, Mitchell B., additional, Salsamendi, Jason, additional, Sanford, Arthur P., additional, Savetamal, Alisa, additional, Scalea, Thomas M., additional, Schecter, William, additional, Schipper, Paul H., additional, Schreiber, Martin A., additional, Schroll, Rebecca W., additional, Schulingkamp, Danielle, additional, Schulman, Carl I., additional, Schulz, John T., additional, Shackelford, Stacy A., additional, Shadis, Ryan, additional, Shapiro, Marc J., additional, Shatz, David V., additional, Shiroff, Adam M., additional, Sicard, Gregorio, additional, Sifri, Ziad C., additional, Sing, Ronald F., additional, Sisley, Amy, additional, Smith, Brian P., additional, Smith, R. Stephen, additional, Singares, Eduardo Smith, additional, Sola, Richard, additional, Spain, David A., additional, Spencer, Audrey L., additional, Stavas, Joseph, additional, Stawicki, Stanislaw P., additional, Stein, Deborah M., additional, Stewart, Nakosi, additional, Stirparo, Joseph J., additional, Strong, Bethany L., additional, Sukumar, Mithran S., additional, Tadlock, Matthew D., additional, Taylor, John R., additional, Thaller, Seth R., additional, Thomas, Bradley W., additional, Thompson, Ashley M., additional, Tieu, Brandon H., additional, Tillou, Areti, additional, Tinkoff, Glen H., additional, Tisherman, Samuel A., additional, Todd, S. Rob, additional, Tominaga, Gail T., additional, Trammell, Amy Phillips, additional, Trunkey, Donald D., additional, Tuggle, David, additional, Upchurch, Gilbert R., additional, Van, Philbert, additional, VanDerHeyden, Nicole, additional, Vanzant, Erin L., additional, Wall, Matthew J., additional, Wenzl, Florian A., additional, Whitlow, Christopher T., additional, Wiegand, Lucas R., additional, Williams, Timothy K., additional, Wilson, Jonathan L., additional, Yeh, D. Dante, additional, Youngblood, Charles F., additional, and Zhang, Wei, additional

Published
2024
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15. Grazers and predators mediate the post-settlement bottleneck in Caribbean octocoral forests

Author

Christopher D. Wells, Joseph Benz, Kaitlyn J. Tonra, Emily R. Anderson, and Howard R. Lasker

Subjects
gorgonian, recruitment dynamics, coral settlement, early-life history, U.S. Virgin Islands, planulae, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

In the Caribbean, reef-building scleractinian corals have declined precipitously and octocorals have emerged as one of their main successors. The success of octocorals and the formation of octocoral forests has been attributed to their continuing recruitment to reef habitats, as well as tolerance to pollution, reduced direct competition with scleractinians, and resistance and resilience to climatic events. Benthic grazers on coral reefs can facilitate the growth and recruitment of corals by reducing the abundance of competitive algal turfs and macroalgae. However, grazing can also hinder corals through sublethal damage to coral tissue and predation of recruits. We assessed the effects of grazing by fishes and the sea urchin Diadema antillarum as well as predation by mesofauna on octocoral recruitment through a series of manipulative in situ and ex situ experiments. Exposure to fish and urchin grazing significantly reduced the post-settlement survival of octocoral recruits, while turf-associated mesofauna did not significantly affect recruitment. We also found a positive relationship between octocoral recruitment and the abundance of turf algae, which may reflect the deleterious effect of grazing on both turf algae and octocoral recruits. These data suggest that grazers and predators mediate the bottleneck characteristic of recruitment, primarily through their effect on post-settlement survival. Thus, the declines in the abundance of grazing fishes and urchins throughout the Caribbean may have contributed to the increase in Caribbean octocoral abundance, concurrent with the loss of scleractinians.

Published
2024
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18. Understanding Traditional and Nontraditional Students' Job Skill Preparation from a Career Capital Perspective

Author

Xing, Xue and Gordon, Howard R. D.

Abstract

Using data from the 2014 Community College Survey of Student Engagement (CCSSE), we examined traditional and nontraditional students' perceived preparation for job skills in terms of the "three ways of knowing" from a career capital perspective. Results showed that traditional and nontraditional students shared commonalities as well as differences in terms of "three ways of knowing." Multinomial regression showed that different sets of predicators were significant in predicting students' perceived preparation for job skills, depending on the outcome being considered. However, variables that are directly aligned to the work or job preparation -- updating job skills as a goal, work-based learning, and using job placement assistance, each representing one way of knowing -- had the largest odds ratios in explaining the perceived preparation for job skills. Discussions of findings and implications are provided.

Published
2023
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19. The deep evolution of Ecdysozoa

Author

Howard, R. and Ma, Xiaoya

Subjects
palaeontology, invertebrate palaeontology, cambrian period, evolution, phylogenetics, molcular clock, invertebrate zoology
Abstract

Ecdysozoa (moulting animals) comprises the protostome Phyla Arthropoda, Kinorhyncha, Loricifera, Nematoda, Nematomorpha, Onychophora, Priapulida and Tardigrada, but our precise understanding of the phylogenetic relationships between these is disputed. Ecdysozoa is an extremely ancient clade that originated in the oceans, and ecdysozoans remain major components of modern marine and terrestrial ecosystems, including the most diverse and abundant of all animal Phyla (Arthropoda and Nematoda respectively). In this thesis, I explore the phylogenetic relationships and divergence times of fossil and extant ecdysozoans in order to address several outstanding issues in the early evolutionary history and palaeobiology of Ecdysozoa, employing data from fossils and molecular sequences. First, the phylogenetic relationships of the eight ecdysozoan phyla was tested using Bayesian models from a molecular matrix containing newly sequenced taxa from Nematomorpha, Priapulida and Tardigrada. Analyses retrieved a monophyletic Scalidophora (Kinorhyncha, Loricifera and Priapulida) which in turn is sister-group to a clade comprising Nematoida (Nematoda and Nematomorpha) and Panarthropoda (Arthropoda, Onychophora and Tardigrada) - this is named Cryptovermes nov. An improved set of fossil calibrations was compiled and used to infer the divergence times of ecdysozoans under a range of alternative parameters. Crown-group Ecdysozoa diverged in the Ediacaran Period between 636-578 Ma, at least 23 million years before the oldest potential fossil evidence of ecdysozoans in the late Ediacaran (<556 Ma). Arthropods show more precision and less incongruence with the fossil record compared to other ecdysozoan phyla. Several vermiform (worm-like) fossils from the exceptionally preserved Cambrian Stage 3 Chengjiang Biota of Yunnan Province, south-western China were investigated to address the origin of Ecdysozoa and Panarthropoda in a morphological phylogenetic context. Phylogenetic analyses placed Acosmia maotiania in stem-group Ecdysozoa. Ancestral character state reconstructions revealed the similarities and contrasts between the stem-group ecdysozoan A. maotiania and a reconstruction of the common ancestor of crown-group Ecdysozoa. This reveals that pharyngeal teeth and circumoral armament are likely to be derived traits of the ecdysozoan crown-group, and may have 3 influenced the diversification of crown-group ecdysozoans - perhaps facilitating a change in feeding style (e.g. predation). The cycloneuralians Tabelliscolex hexagonus, Cricocosmia jinningensis and Mafangscolex yunnanensis (=Palaeoscolecidomorpha nov.) share several characters in common with lobopodian panarthropods. This includes paired, seriated ventral trunk structures, corresponding (in T. hexagonus and C. jinningensis) to seriated lateral/dorsolateral trunk sclerites with a net-like microstructure. However, phylogenetic analyses did not retrieve a relationship between palaeoscolecidomorphs and panarthropods, indicating that this style of morphological seriation may have multiple origins within Ecdysozoa. The lobopodian Facivermis yunnanicus is rejected as a model system to understand the acquisition a segmental bodyplan with paired appendages in Panarthropoda. Phylogenies generated here indicate that F. yunnanicus' worm-like appearance is secondarily adapted from more typical lobopodian ancestors, as a result of adaptation to a specialised tube-dwelling suspension-feeding ecology. Finally, the phylogenetic relationships and divergence times of chelicerate arthropod groups were inferred, and interpreted in the context of arthropod terrestrialization. Phylogenetic analysis of a highly complete matrix of slowly evolving genes supports the monophyly of arachnids. Furthermore, it is parsimonious that the common ancestor of scorpions and other air-breathing arachnids was terrestrial - or at least amphibious - if arachnids are a monophyletic group. Molecular clocks estimate that arachnids diverged in the Cambrian or Early Ordovician, though body fossils of these arthropods are absent until the Silurian which supports the hypothesis of paleontologically cryptic early terrestrial biosphere - mirrored by the molecular and fossil records of myriapods and land plants. Scorpions are the oldest extant terrestrial chelicerate lineage in the fossil record, but is unclear whether the earliest Silurian examples were marine, terrestrial, or even secondarily marine in life.

Published
2022

21. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author

Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R

Published
2024
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22. Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting

Author

Miyahira, Andrea K, Zarif, Jelani C, Coombs, Catherine C, Flavell, Robert R, Russo, Joshua W, Zaidi, Samir, Zhao, Di, Zhao, Shuang G, Pienta, Kenneth J, and Soule, Howard R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Human Genome, Prostate Cancer, Cancer Genomics, Cancer, Urologic Diseases, Aging, Genetics, Congresses as Topic, Humans, Immunotherapy, Male, Prostate, Prostatic Neoplasms, Research, cancer immunotherapy, molecular imaging, precision medicine, therapeutics, tumor genomics, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionThe 2021 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Prostate Cancer Research in the 21st Century," was held virtually, from June 24-25, 2021.MethodsThe CHPCA Meeting is organized by the Prostate Cancer Foundation as a unique discussion-oriented meeting focusing on critical topics in prostate cancer research envisioned to bridge the next major advances in prostate cancer biology and treatment. The 2021 CHPCA Meeting was virtually attended by 89 investigators and included 31 talks over nine sessions.ResultsMajor topic areas discussed at the meeting included: cancer genomics and sequencing, functional genomic approaches to studying mediators of plasticity, emerging signaling pathways in metastatic castration resistant prostate cancer, Wnt signaling biology and the challenges of targeted therapy, clonal hematopoiesis, neuroendocrine cell plasticity and antitumor immunity, cancer immunotherapy and its synergizers, and imaging the tumor microenvironment and metabolism.DiscussionThis meeting report summarizes the research presented at the 2021 CHPCA Meeting. We hope that publication of this knowledge will accelerate new understandings and the development of new biomarkers and treatments for prostate cancer.

Published
2022

24. Career Exploration at the Middle School Level: Barriers and Opportunities

Author

Godbey, Samantha and Gordon, Howard R. D.

Abstract

In this essay, we discuss issues related to the integration of career exploration in our nation's middle schools. We discuss the theoretical and empirical basis for career exploration at the middle school level and identify selected barriers to its effective implementation, namely with regards to career advising and parent involvement. We also propose new directions for practice and research as we work to counteract these barriers.

Published
2019

26. Characteristics and Treatment Patterns of Long-surviving Patients With Multiple Myeloma: Over 13 Years of Follow-up in the ConnectⓇ MM Registry

Author

Terebelo, Howard R., Omel, James, Wagner, Lynne I., Hardin, James W., Rifkin, Robert M., Ailawadhi, Sikander, Durie, Brian G.M., Narang, Mohit, Toomey, Kathleen, Gasparetto, Cristina J., Joshi, Prashant, Yu, Edward, Flick, E. Dawn, Jou, Ying-Ming, Lee, Hans C., Abonour, Rafat, and Jagannath, Sundar

Published
2024
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27. What Applied Physical Chemistry Can Contribute to Understanding Cancer: Toward the Next Generation of Breakthroughs

Author

Parker Schanen and Howard R. Petty

Subjects
chemical adducts, carcinogenicity, breast cancer recurrences, metabolism, machine learning, enzyme clustering and agglomeration, Analytical chemistry, QD71-142, General. Including alchemy, QD1-65
Abstract

Living systems, whether healthy or diseased, must obey the laws of chemistry. The purpose of this review is to identify the interpretive limits of cellular biochemistry using, largely, the tools of physical chemistry. We illustrate this approach using two major concepts in cancer: carcinogenicity and cancer recurrences. Cells optimize the chemical performance of enzymes and pathways during cancer recurrences. Biology has been primarily concerned with the analysis of high affinity interactions, such as ligand–receptor interactions. Collective weak interactions (such as van der Waals forces) are also important in determining biosystem behaviors, although they are infrequently considered in biology. For example, activity coefficients determine the effective concentrations of biomolecules. The in vivo performance of enzymes also depends upon intracellular conditions such as high protein concentrations and multiple regulatory factors. Phase separations within membranes (two dimensions) and nucleoli (three dimensions) are a fundamental regulatory factor within cells, as phase separations can alter reactant concentrations, local dielectric constants, and other factors. Enzyme agglomeration also affects the performance of biochemical pathways. Although there are many examples of these phenomena, we focus on the key steps of cancer: carcinogenicity and the biochemical mechanism of cancer recurrences. We conjecture that oxidative damage to histones contributes to carcinogenicity, which is followed by nucleolar phase separations and subsequent DNA damage that, in turn, contributes to the redistribution of enzymes mediating metabolic changes in recurrent breast cancer.

Published
2023
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37. Enhancing consumer sensory science approach through augmented virtuality

Author

Abdul Hannan Bin Zulkarnain, Howard R. Moskowitz, Zoltán Kókai, and Attila Gere

Subjects
Mixed Reality (MR), Extended Reality (XR), Immersive, Consumer perception, Digital Sensory, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Augmented Virtuality (AV) is a concept that merges components of Augmented Reality (AR) and Virtual Reality (VR), incorporating real elements into a virtual environment. This review analyses the influence of AV technology on sensory science and consumer behaviour, with the potential to improve product evaluation through sensory analysis. The objective is to develop immersive sensory environments that closely resemble real-world scenarios, offering accurate insights into consumer perceptions and preferences. Participants will be able to observe genuine food products within the virtual environment. Through the utilization of a multidisciplinary approach, the analysis explores the point at which technology and human senses intersect, revealing new and unique understandings of decision-making processes. This enhances comprehension of consumer choices and behaviour in virtual environments, providing practical uses for industries navigating the ever-changing nature of augmented virtuality. This review demonstrates that the integration of AV elements in sensory science can have a substantial influence.

Published
2024
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38. The Solar Orbiter Science Activity Plan: translating solar and heliospheric physics questions into action

Author

Zouganelis, I., De Groof, A., Walsh, A. P., Williams, D. R., Mueller, D., Cyr, O. C. St, Auchere, F., Berghmans, D., Fludra, A., Horbury, T. S., Howard, R. A., Krucker, S., Maksimovic, M., Owen, C. J., Rodriiguez-Pacheco, J., Romoli, M., Solanki, S. K., Watson, C., Sanchez, L., Lefort, J., Osuna, P., Gilbert, H. R., Nieves-Chinchilla, T., Abbo, L., Alexandrova, O., Anastasiadis, A., Andretta, V., Antonucci, E., Appourchaux, T., Aran, A., Arge, C. N., Aulanier, G., Baker, D., Bale, S. D., Battaglia, M., Rubio, L. Bellot, Bemporad, A., Berthomier, M., Bocchialini, K., Bonnin, X., Brun, A. S., Bruno, R., Buchlin, E., Buechner, J., Bucik, R., Carcaboso, F., Carr, R., Carrasco-Blazquez, I., Cecconi, B., Cangas, I. Cernuda, Chen, C. H. K., Chitta, L. P., Chust, T., Dalmasse, K., D'Amicis, R., Da Deppo, V., De Marco, R., Dolei, S., Dolla, L., de Wit, T. Dudok, van Driel-Gesztelyi, L., Eastwood, J. P., Lara, F. Espinosa, Etesi, L., Fedorov, A., Felix-Redondo, F., Fineschi, S., Fleck, B., Fontaine, D., Fox, N. J., Gandorfer, A., Genot, V., Georgoulis, M. K., Gissot, S., Giunta, A., Gizon, L., Gomez-Herrero, R., Gontikakis, C., Graham, G., Green, L., Grundy, T., Haberreiter, M., Harra, L. K., Hassler, D. M., Hirzberger, J., Ho, G. C., Hurford, G., Innes, D., Issautier, K., James, A. W., Janitzek, N., Janvier, M., Jeffrey, N., Jenkins, J., Khotyaintsev, Y., Klein, K. -L., Kontar, E. P., Kontogiannis, I., Krafft, C., Krasnoselskikh, V., Kretzschmar, M., Labrosse, N., Lagg, A., Landini, F., Lavraud, B., Leon, I., Lepri, S. T., Lewis, G. R., Liewer, P., Linker, J., Livi, S., Long, D. M., Louarn, P., Malandraki, O., Maloney, S., Martinez-Pillet, V., Martinovic, M., Masson, A., Matthews, S., Matteini, L., Meyer-Vernet, N., Moraitis, K., Morton, R. J., Musset, S., Nicolaou, G., Nindos, A., O'Brien, H., Suarez, D. Orozco, Owens, M., Pancrazzi, M., Papaioannou, A., Parenti, S., Pariat, E., Patsourakos, S., Perrone, D., Peter, H., Pinto, R. F., Plainaki, C., Plettemeier, D., Plunkett, S. P., Raines, J. M., Raouafi, N., Reid, H., Retino, A., Rezeau, L., Rochus, P., Rodriguez, L., Rodriguez-Garcia, L., Roth, M., Rouillard, A. P., Sahraoui, F., Sasso, C., Schou, J., Schuehle, U., Sorriso-Valvo, L., Soucek, J., Spadaro, D., Stangalini, M., Stansby, D., Steller, M., Strugarek, A., Stverak, S., Susino, R., Telloni, D., Terasa, C., Teriaca, L., Toledo-Redondo, S., Iniesta, J. C. del Toro, Tsiropoula, G., Tsounis, A., Tziotziou, K., Valentini, F., Vaivads, A., Vecchio, A., Velli, M., Verbeeck, C., Verdini, A., Verscharen, D., Vilmer, N., Vourlidas, A., Wicks, R., Wimmer-Schweingruber, R. F., Wiegelmann, T., Young, P. R., and Zhukov, A. N.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Solar Orbiter is the first space mission observing the solar plasma both in situ and remotely, from a close distance, in and out of the ecliptic. The ultimate goal is to understand how the Sun produces and controls the heliosphere, filling the Solar System and driving the planetary environments. With six remote-sensing and four in-situ instrument suites, the coordination and planning of the operations are essential to address the following four top-level science questions: (1) What drives the solar wind and where does the coronal magnetic field originate? (2) How do solar transients drive heliospheric variability? (3) How do solar eruptions produce energetic particle radiation that fills the heliosphere? (4) How does the solar dynamo work and drive connections between the Sun and the heliosphere? Maximising the mission's science return requires considering the characteristics of each orbit, including the relative position of the spacecraft to Earth (affecting downlink rates), trajectory events (such as gravitational assist manoeuvres), and the phase of the solar activity cycle. Furthermore, since each orbit's science telemetry will be downloaded over the course of the following orbit, science operations must be planned at mission level, rather than at the level of individual orbits. It is important to explore the way in which those science questions are translated into an actual plan of observations that fits into the mission, thus ensuring that no opportunities are missed. First, the overarching goals are broken down into specific, answerable questions along with the required observations and the so-called Science Activity Plan (SAP) is developed to achieve this. The SAP groups objectives that require similar observations into Solar Orbiter Observing Plans (SOOPs), resulting in a strategic, top-level view of the optimal opportunities for science observations during the mission lifetime., Comment: 20 pages, 1 figure, accepted by Astronomy & Astrophysics

Published
2020
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39. Trajectory Determination for Coronal Ejecta Observed by WISPR/Parker Solar Probe

Author

Liewer, P. C., Qiu, J., Penteado, P., Hall, J. R., Vourlidas, A., and Howard, R. A.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The {\it Wide-field Imager for Solar Probe} (WISPR) on {\it Parker Solar Probe} (PSP), observing in white light, has a fixed angular field of view, extending from 13.5$^{\circ}$ to 108$^{\circ}$ from the Sun and approximately 50$^{\circ}$ in the transverse directions. Because of the highly elliptical orbit of PSP, the physical extent of the imaged coronal region varies directly as the distance from the Sun, requiring new techniques for analysis of the motions of observed density features. Here, we present a technique for determining the 3D trajectory of CMEs and other coronal ejecta moving radially at a constant velocity by first tracking the motion in a sequence of images and then applying a curve-fitting procedure to determine the trajectory parameters (distance vs. time, velocity, longitude and latitude). To validate the technique, we have determined the trajectory of two CMEs observed by WISPR that were also observed by another white-light imager, either LASCO/C3 or STEREO-A/HI1. The second viewpoint was used to verify the trajectory results from this new technique and help determine its uncertainty., Comment: 28 pages, 11 figures, accepted by Solar Physics

Published
2020
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40. The Solar Orbiter mission -- Science overview

Author

Müller, D., Cyr, O. C. St., Zouganelis, I., Gilbert, H. R., Marsden, R., Nieves-Chinchilla, T., Antonucci, E., Auchère, F., Berghmans, D., Horbury, T., Howard, R. A., Krucker, S., Maksimovic, M., Owen, C. J., Rochus, P., Rodriguez-Pacheco, J., Romoli, M., Solanki, S. K., Bruno, R., Carlsson, M., Fludra, A., Harra, L., Hassler, D. M., Livi, S., Louarn, P., Peter, H., Schühle, U., Teriaca, L., Iniesta, J. C. del Toro, Wimmer-Schweingruber, R. F., Marsch, E., Velli, M., De Groof, A., Walsh, A., and Williams, D.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Solar Orbiter, the first mission of ESA's Cosmic Vision 2015-2025 programme and a mission of international collaboration between ESA and NASA, will explore the Sun and heliosphere from close up and out of the ecliptic plane. It was launched on 10 February 2020 04:03 UTC from Cape Canaveral and aims to address key questions of solar and heliospheric physics pertaining to how the Sun creates and controls the Heliosphere, and why solar activity changes with time. To answer these, the mission carries six remote-sensing instruments to observe the Sun and the solar corona, and four in-situ instruments to measure the solar wind, energetic particles, and electromagnetic fields. In this paper, we describe the science objectives of the mission, and how these will be addressed by the joint observations of the instruments onboard. The paper first summarises the mission-level science objectives, followed by an overview of the spacecraft and payload. We report the observables and performance figures of each instrument, as well as the trajectory design. This is followed by a summary of the science operations concept. The paper concludes with a more detailed description of the science objectives. Solar Orbiter will combine in-situ measurements in the heliosphere with high-resolution remote-sensing observations of the Sun to address fundamental questions of solar and heliospheric physics. The performance of the Solar Orbiter payload meets the requirements derived from the mission's science objectives. Its science return will be augmented further by coordinated observations with other space missions and ground-based observatories., Comment: 32 pages, 30 figures; accepted for publication in A&A

Published
2020
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41. Is local review of positron emission tomography scans sufficient in diffuse large B‐cell lymphoma clinical trials? A CALGB 50303 analysis

Author

Pallawi Torka, Levi D. Pederson, Michael V. Knopp, David Poon, Jun Zhang, Brad S. Kahl, Howard R. Higley, Gary Kelloff, Jonathan W. Friedberg, Lawrence H. Schwartz, Wyndham H. Wilson, John P. Leonard, Nancy L. Bartlett, Heiko Schöder, and Amy S. Ruppert

Subjects
Deauville 5‐PS, interim PET, International Harmonization Project criteria, visual scoring system, ΔSUV, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Quantitative methods of Fluorodeoxyglucose Positron Emission Tomography (FDG‐PET) interpretation, including the percent change in FDG uptake from baseline (ΔSUV), are under investigation in lymphoma to overcome challenges associated with visual scoring systems (VSS) such as the Deauville 5‐point scale (5‐PS). Methods In CALGB 50303, patients with DLBCL received frontline R‐CHOP or DA‐EPOCH‐R, and although there were no significant associations between interim PET responses assessed centrally after cycle 2 (iPET) using 5‐PS with progression‐free survival (PFS) or overall survival (OS), there were significant associations between central determinations of iPET ∆SUV with PFS/OS. In this patient cohort, we retrospectively compared local vs central iPET readings and evaluated associations between local imaging data and survival outcomes. Results Agreement between local and central review was moderate (kappa = 0.53) for VSS and high (kappa = 0.81) for ∆SUV categories (

Published
2023
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42. Meta-Analytic Procedures for Career and Technical Education Postsecondary Researchers and Practitioners

Author

Oh-Young, Conrad, Gordon, Howard R. D., Xing, Xue, and Filler, John

Abstract

Meta-analytic studies are syntheses of literature in which researchers use statistical means to summarize the findings presented across primary studies. They are of great interest in the fields of medicine and social sciences with numerous examples published in peer-reviewed journals. However, it appears that career and technical education (CTE) researchers are either not performing these research syntheses, or are not publishing their findings. Thus, there are three purposes to this manuscript. The first is to present CTE researchers and practitioners with a rationale as to why meta-analyses should be performed. The second is to provide guidelines that researchers and practitioners use to perform their own meta-analyses. The third is to provide suggestions that researchers and practitioners can use to disseminate the results of their meta-analyses. The manuscript concludes with a listing of suggested areas for future research.

Published
2018

43. Airbag associated ocular alkaline chemical injury: A case report

Author

John P. Korducki, Nicholas Maxwell, Howard R. Day, and Aaron J. Lacy

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Background: Airbags are a life-saving apparatus for patients involved in motor vehicle collisions (MVC). However, part of that apparatus includes the presence of alkaline chemicals that can induce ocular injury. Traumatic eye injuries are well documented in the literature in the setting of MVCs, yet ocular alkali burns are under-recognized and a dearth of case reports exists. Case report: A 26-year-old male presented following an MVC complaining of severe unilateral eye pain in the setting of direct airbag related trauma. Ocular pH testing later revealed an alkaline injury of the right eye. Ocular irrigation was initiated in the emergency department until the pH reached normal levels. Why should an emergency physician be aware of this?: Recognition of airbag-associated alkaline chemical burns of the eye in the setting of an MVC and appropriate management are imperative to avoid deleterious outcomes such as permanent vision loss.

Published
2023
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48. Comparing extrapolations of the coronal magnetic field structure at 2.5 solar radii with multi-viewpoint coronagraphic observations

Author

Sasso, C., Pinto, R. F., Andretta, V., Howard, R. A., Vourlidas, A., Bemporad, A., Dolei, S., Spadaro, D., Susino, R., Antonucci, E., Abbo, L., Da Deppo, V., Fineschi, S., Frassetto, F., Landini, F., Naletto, G., Nicolini, G., Nicolosi, P., Pancrazzi, M., Romoli, M., Telloni, D., and Ventura, R.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract

The magnetic field shapes the structure of the solar corona but we still know little about the interrelationships between the coronal magnetic field configurations and the resulting quasi-stationary structures observed in coronagraphic images (as streamers, plumes, coronal holes). One way to obtain information on the large-scale structure of the coronal magnetic field is to extrapolate it from photospheric data and compare the results with coronagraphic images. Our aim is to verify if this comparison can be a fast method to check systematically the reliability of the many methods available to reconstruct the coronal magnetic field. Coronal fields are usually extrapolated from photospheric measurements typically in a region close to the central meridian on the solar disk and then compared with coronagraphic images at the limbs, acquired at least 7 days before or after to account for solar rotation, implicitly assuming that no significant changes occurred in the corona during that period. In this work, we combine images from three coronagraphs (SOHO/LASCO-C2 and the two STEREO/SECCHI-COR1) observing the Sun from different viewing angles to build Carrington maps covering the entire corona to reduce the effect of temporal evolution to ~ 5 days. We then compare the position of the observed streamers in these Carrington maps with that of the neutral lines obtained from four different magnetic field extrapolations, to evaluate the performances of the latter in the solar corona. Our results show that the location of coronal streamers can provide important indications to discriminate between different magnetic field extrapolations., Comment: Accepted by A&A the 20th of May, 2019

Published
2019
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49. Accelerating precision medicine in metastatic prostate cancer

Author

Mateo, Joaquin, McKay, Rana, Abida, Wassim, Aggarwal, Rahul, Alumkal, Joshi, Alva, Ajjai, Feng, Felix, Gao, Xin, Graff, Julie, Hussain, Maha, Karzai, Fatima, Montgomery, Bruce, Oh, William, Patel, Vaibhav, Rathkopf, Dana, Rettig, Matthew, Schultz, Nikolaus, Smith, Matthew, Solit, David, Sternberg, Cora, Van Allen, Eliezer, VanderWeele, David, Vinson, Jake, Soule, Howard R, Chinnaiyan, Arul, Small, Eric, Simons, Jonathan W, Dahut, William, Miyahira, Andrea K, and Beltran, Himisha

Subjects
Clinical Research, Human Genome, Genetics, Cancer, Biotechnology, Urologic Diseases, Aging, Health Services, Prostate Cancer, Good Health and Well Being, Early Detection of Cancer, Humans, Male, Medical Oncology, Precision Medicine, Prostate-Specific Antigen, Prostatic Neoplasms
Abstract

Despite advances in prostate cancer screening and treatment, available therapy options, particularly in later stages of the disease, remain limited and the treatment-resistant setting represents a serious unmet medical need. Moreover, disease heterogeneity and disparities in patient access to medical advances result in significant variability in outcomes across patients. Disease classification based on genomic sequencing is a promising approach to identify patients whose tumors exhibit actionable targets and make more informed treatment decisions. Here we discuss how we can accelerate precision oncology to inform broader genomically-driven clinical decisions for men with advanced prostate cancer, drug development and ultimately contribute to new treatment paradigms.

Published
2020

50. Meeting report from the Prostate Cancer Foundation PSMA theranostics state of the science meeting

Author

Miyahira, Andrea K, Pienta, Kenneth J, Babich, John W, Bander, Neil H, Calais, Jeremie, Choyke, Peter, Hofman, Michael S, Larson, Steven M, Lin, Frank I, Morris, Michael J, Pomper, Martin G, Sandhu, Shahneen, Scher, Howard I, Tagawa, Scott T, Williams, Scott, and Soule, Howard R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Prostate Cancer, Aging, Cancer, Biomedical Imaging, Good Health and Well Being, Humans, Male, Molecular Targeted Therapy, Precision Medicine, Prostatic Neoplasms, Theranostic Nanomedicine, clinical trials, medical oncology, nuclear medicine, PET imaging, prostate-specific membrane antigen, radiation therapy, radiology, radionuclides, radiopharmaceuticals, urology, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionThe Prostate Cancer Foundation (PCF) convened a PCF prostate-specific membrane antigen (PSMA) Theranostics State of the Science Meeting on 18 November 2019, at Weill Cornell Medicine, New York, NY.MethodsThe meeting was attended by 22 basic, translational, and clinical researchers from around the globe, with expertise in PSMA biology, development and use of PSMA theranostics agents, and clinical trials. The goal of this meeting was to discuss the current state of knowledge, the most important biological and clinical questions, and critical next steps for the clinical development of PSMA positron emission tomography (PET) imaging agents and PSMA-targeted radionuclide agents for patients with prostate cancer.ResultsSeveral major topic areas were discussed including the biology of PSMA, the role of PSMA-targeted PET imaging in prostate cancer, the physics and performance of different PSMA-targeted PET imaging agents, the current state of clinical development of PSMA-targeted radionuclide therapy (RNT) agents, the role of dosimetry in PSMA RNT treatment planning, barriers and challenges in PSMA RNT clinical development, optimization of patient selection for PSMA RNT trials, and promising combination treatment approaches with PSMA RNT.DiscussionThis article summarizes the presentations from the meeting for the purpose of globally disseminating this knowledge to advance the use of PSMA-targeted theranostic agents for imaging and treatment of patients with prostate cancer.

Published
2020

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