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673 results on '"HOP, WIM C. J."'

1. Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial

Author

Nieuwenhuizen, Jeroen, Hop, Wim C J, Burger, Pim C W, Verhagen, Hence J, Klitsie, Pieter J, van de Berg, Michiel, Golling, Markus, Jairam, An P, Timmermans, Lucas, Eker, Hasan H, Pierik, Robert E G J M, van Klaveren, David, Steyerberg, Ewout W, Timman, Reinier, van der Ham, Arie C, Dawson, Imro, Charbon, Jan A, Schuhmacher, Christoph, Mihaljevic, André, Izbicki, Jakob R, Fikatas, Panagiotis, Knebel, Philip, Fortelny, René H, Kleinrensink, Gert-Jan, Lange, Johan F, and Jeekel, Hans J

Published
2017
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19. One single dose of etomidate negatively influences adrenocortical performance for at least 24a-h in children with meningococcal sepsis

Author

Brinker, Marieke, Hokken-Koelega, Anita C. S., Hazelzet, Jan A., Jong, Frank H., Hop, Wim C. J., and Joosten, Koen F. M.

Subjects
Etomidate -- Dosage and administration, Etomidate -- Complications and side effects, Sepsis -- Drug therapy, Sepsis -- Patient outcomes, Health care industry
Abstract

Byline: Marieke Brinker (1,2,5), Anita C. S. Hokken-Koelega (2), Jan A. Hazelzet (1,2), Frank H. Jong (3), Wim C. J. Hop (4), Koen F. M. Joosten (1) Keywords: Adrenal insufficiency; Etomidate; Critical illness; Meningococcal disease; Child Abstract: Objective To investigate the effect of one single bolus of etomidate used for intubation on adrenal function in children with meningococcal sepsis. Design Retrospective study conducted between 1997 and 2004. Setting University-affiliated paediatric intensive care unit (PICU). Patients and participants Sixty children admitted to the PICU with meningococcal sepsis, not treated with steroids. Interventions Adrenal hormone concentrations were determined as soon as possible after PICU admission, and after 12a-h and 24a-h. To assess disease severity, PRISM score and selected laboratory parameters were determined. Measurements and main results On admission, before blood was drawn, 23 children had been intubated with etomidate, 8 without etomidate and 29 were not intubated. Children who were intubated had significantly higher disease severity parameters than those not intubated, whereas none of these parameters significantly differed between children intubated with or without etomidate. Children who received etomidate had significantly lower cortisol, higher ACTH and higher 11-deoxycortisol levels than those who did not receive etomidate. Arterial glucose levels were significantly lower in children who were intubated with etomidate than in non-intubated children. When children were intubated with etomidate, cortisol levels were 3.2 times lower for comparable 11-deoxycortisol levels. Eight children died, seven of whom had received etomidate. Within 24a-h cortisol/ACTH and cortisol/11-deoxycortisol ratios increased significantly in children who received etomidate, but not in children who did not, resulting in comparable cortisol/ACTH ratios with still significantly lowered cortisol/11-deoxycortisol ratios 24a-h after admission. Conclusions Our data imply that even one single bolus of etomidate negatively influences adrenal function for at least 24a-h. It might therefore increase risk of death. Author Affiliation: (1) Department of Pediatrics, Division of Pediatric Intensive Care, Erasmus MC--Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands (2) Division of Endocrinology, Erasmus MC--Sophia Children's Hospital, Rotterdam, The Netherlands (3) Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands (4) Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands (5) Department of Pediatrics, Ghent University, Ghent, Belgium Article History: Registration Date: 23/07/2007 Received Date: 22/03/2007 Accepted Date: 17/07/2007 Online Date: 21/08/2007

Published
2008

30. Results of 2 years of treatment with protease-inhibitor-containing antiretroviral therapy in Dutch children infected with human immunodeficiency virus type 1. (HIV/AIDS: Major Article)

Author

van Rossum, Annemarie M.C., Geelen, Sibyl P.M., Hartwig, Nico G., Wolfs, Tom F. W., Weemaes, Corry M. R., Scherpbier, Henriette J., van Lochem, Ellen G., Hop, Wim C. J., Schutten, Martin, Osterhaus, Albert D. M. E., Burger, David M., and Groat, Ronald de

Subjects
Protease inhibitors -- Usage, Antiviral agents -- Usage, Drug therapy -- Usage, HIV (Viruses) -- Drug therapy, Children -- Diseases, Health, Health care industry
Published
2002

48. Three-dimensional sonographic measurement of normal fetal brain volume during the second half of pregnancy

Author

Roelfsema, Nanette M., Hop, Wim C. J., Wladimiroff, Juriy W., and Boito, Simona M. E.

Subjects
Fetal brain -- Medical examination, Ultrasound imaging -- Usage, Health
Abstract

A study was conducted to develop a three-dimensional (3D) brain volumemethod of measuring fetal brain volume. It was concluded that sonographic measurement of fetal brain volume demonstrated acceptable intraobserver variability and a nearly 10-fold increase during the second half of gestation.

Published
2004

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