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Background: Botulinum neurotoxin type A (BoNT‐A) is well‐established for treatment of glabellar lines (GLs), and mostly formulated as powders requiring reconstitution for injection. The approved liquid formulation, ready‐to‐use (RTU) abobotulinumtoxinA was developed to ease injection procedures and prevent reconstitution errors. This multicenter, open‐label, Phase IV study evaluated GL treatment experience using RTU abobotulinumtoxinA versus powder BoNT‐A (onabotulinumtoxinA). Methods: Females with experience of BoNT‐A facial treatment were randomized 2:1 to GL treatment with 50 U RTU abobotulinumtoxinA (N = 99) or 20 U powder BoNT‐A (N = 51) and followed‐up for 6 months or 1 month, respectively. Assessments included: time to prepare each product for injection (primary endpoint); investigators' experience with product preparation/reconstitution; investigators' and subjects' treatment experience; safety; and for the RTU product: aesthetic improvement of GLs; subject satisfaction. Results: Compared with powder BoNT‐A, RTU abobotulinumtoxinA required statistically significantly less preparation time (mean 0:33 vs. 1:34 min: s; p < 0.0001). Investigators preferred RTU abobotulinumtoxinA over powder BoNT‐A (81% of treatment sessions) and found it allowed more time to communicate with subjects (97%). All investigators (100%) also found it easy‐to‐use, easy‐to‐learn, and that it fulfilled their expectations. Subjects found the RTU abobotulinumtoxinA treatment comfortable (91%), and through 6 months posttreatment, most reported satisfaction with their appearance (≥88%), looking natural (≥95%) and refreshed (≥80%). At Month 1, 99% of RTU‐treated subjects had investigator‐assessed improved aesthetic appearance in GLs, maintained in 76% at Month 6. No serious adverse events occurred. Conclusion: RTU abobotulinumtoxinA for GL treatment is well‐tolerated, efficacious, shows high levels of subject satisfaction throughout 6 months, saves time, and is preferred by clinicians over powder BoNT‐A. ClinicalTrials.gov Registry: NCT05277337. [ABSTRACT FROM AUTHOR]

We present the first results of work towards a foil-based epiretinal prosthesis that can stimulate retinal cells. The prosthesis receives trigger signals and energy in the form of high intensity infrared radiation. Array-like silicon photodiodes with attached thin film electrodes convert the received infrared light into electrical stimulation signals, which are intended to stimulate ganglion cells. The photodiodes are arranged like stones in a mosaic on an only 10 µm thin and thus flexible polymer foil. Like this, the prosthesis can adapt to the curved shape of the eye and will have close contact with the retina.

This paper reports on the evaluation of recurrent and convolutional neural networks as real-time grasp phase classifiers for future control of neuroprostheses for people with high spinal cord injury. A field-programmable gate array has been chosen as an implementation platform due to its form factor and ability to perform parallel computations, which are specific for the selected neural networks. Three different phases of two grasp patterns and the additional open hand pattern were predicted by means of surface Electromyography (EMG) signals (i.e. Seven classes in total). Across seven healthy subjects, CNN (Convolutional Neural Networks) and RNN (Recurrent Neural Networks) had a mean accuracy of 85.23% with a standard deviation of 4.77% and 112 µs per prediction and 83.30% with a standard deviation of 4.36% and 40 µs per prediction, respectively.

The motility of the gastrointestinal tract is crucial for digestive activity and dysfunction can lead to severe disease pattern. A method for analysing the motility is needed when treatment approaches shall be evaluated. Therefore markers attached to different locations on the stomach and the bowel of pigs are video tracked in this research study. The markers are designed to provide a high contrast and have an adhesive side for fixation. Above the operation field a video camera has been placed to film the markers during the procedure. To analyse the video data a special algorithm has been implemented. The algorithm requires a registration process at the beginning of each recording which allows the parallel tracking of multiple markers. After the registration the algorithm tracks the position of the marker frame by frame. Each frame is converted into a greyscale picture by adding specified colour values of each pixel. This allows emphasizing certain colours. The centre of the marker is determined by computing the horizontal and vertical centre of the marker starting at the corresponding marker position of the previous frame. After completion the data is stored as coordinates and a video with the marker position displayed for further processing. For advanced analysis the data can be synchronized with electromyography signals, for example. The marked videos show a promising tracking of the markers. However, if the algorithm loses track of a marker during a recording, it is unlikely to relocate it due to the successive processing of the frames. Nevertheless this method provides a simple and easy to use solution for movement detection of the gastrointestinal tract.

The Institut für Psychoanalyse Zürich-Kreuzlingen (IfP) was founded as a working group in 1972. Its founder Norman Elrod graduated from the Carl-Gustav-Jung-Institute in Zurich and followed a politically and philosophically reflected psychoanalysis. In addition, he was engaged in the treatment of psychotic patients. Quite a few of his co-workers worked in the Psyichiatria Democratica in Italy as well as in institutions in Germany and Switzerland, where they also contributed greatly to psychoanalytically inspired multiprofessional care for severely ill individuals, including forensic patients. [ABSTRACT FROM AUTHOR]

This paper presents the design of implantable electronics as a part of a system for prosthetic hand control. Purpose of the implant is the sensing of electrical signals originating from biological tissue and the actuation of the same, therefore closing the loop and allowing for an improved control of the prosthetic hand. The implant contains two integrated circuits for eight channel EMG monitoring and four channel stimulation, respectively. An on-board microcontroller allows for local pre-processing. All intracorporeal to extracorporeal communications are running through and are directed by the main processing platform. The external components of the control system include, in addition to the main processing and control platform, the inductive power transfer circuits and the pressure sensors for the sensory feedback. Different assembly and encapsulation options are taken into account for the implantable electronics and are unified in a single PCB design.

Aspects and approaches for the design of systems for simultaneous signal and energy transmission for medical implants are presented. The main focus is on the consideration of the mutual influence on both transmission lines. To minimize the influence of capacitive as well as inductive paths, that affect the transmission, reducing the number of components is discussed. In order to increase the degree of miniaturization and reliability, the realization of certain functionalities is based on the so-called parasitics of electrical components. An implementation example is presented.

The usability of flexible electrodes in moving environment is limited due to different mechanical characteristics of their metallic and polymeric components. To achieve structure compatible electrodes, all used materials need to have similar Young’s moduli as the surrounding tissue. This paper describes the characterization of macroscopic as well as miniaturized electrodes entirely made out of modified silicone (PDMS). Electrochemical, mechanical, biological, optical, and applicative methods were used. It could be shown, that PDMS electrodes are capable to be used for recording electrocardiograms with similar form and amplitude as with standard electrodes.

Gastrointestinal (GI) motility disorders are frequent and clinically significant conditions with impairment of patient’s quality of life. Examples range from upper GI symptoms such as dysphagia and gastroparesis to lower GI manifestations, namely chronic-intestinal pseudo obstruction, diarrhea and constipation. Furthermore, postoperative motility disorders are common. Currently, available pharmacological or dietetic treatment options are limited. Since GI motility is based on myoelectric activity, electrical stimulation (ES) is a promising alternative. Numerous studies have demonstrated suitable pacing strategies and parameters in different GI segments. However, results of multilocular ES are rare. We report the first experimental study to evaluate ES of five GI parts in a porcine model. Multi-channel electromyography (EMG) recordings of gastrointestinal baseline and poststimulatory electrical activity were realized together with video-based marker tracking (VBMT). ES provoked visible GI contractions and appeared to modulate frequencies of slow waves and spikes. Further investigations are needed for analysis of locoregional and cross-organ effects of ES on the GI tract.