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The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its role in the prevention of cardiovascular diseases, such as atherosclerosis and myocardial infarction, but also transient ischemic attack and stroke. Previous epidemiological studies have indicated that HDL-C concentration is inversely associated with the risk of cardiovascular disease and that it can be used for risk prediction. Some genetic disorders are characterized by markedly elevated levels of HDL-C; however, they do not translate into diminished cardiovascular risk. The search of the potential causative relationship between HDL-C and adverse events has shifted the attention of researchers towards the composition and function of the HDL molecule/subfractions. HDL possesses various cardioprotective properties. However, currently, it appears that higher HDL-C is not necessarily protective against cardiovascular disease, but it can even be harmful in extremely high quantities.

Groundwater is a vital yet threatened resource in much of South Asia. This paper develops a model of groundwater transactions under payoff uncertainty arising from unpredictable fluctuations in groundwater availability during the agricultural dry season. The model highlights the trade-off between the ex post inefficiency of long-term contracts and the ex ante inefficiency of spot contracts. The structural parameters are estimated using detailed micro-data on the area irrigated under each contract type combined with subjective probability distributions of borewell discharge elicited from a large sample of well-owners in southern India. The findings show that, while the contracting distortion leads to an average welfare loss of less than 2 percent and accounts for less than 50 percent of all transactions costs in groundwater markets, it has a sizeable impact on irrigated area, especially for small farmers. Uncertainty coupled with land fragmentation also attenuates the benefits of the water-saving technologies now being heavily promoted in India.

The Government of Punjab, through Government of India’s (GoI) Department of Economic Affairs (DEA) had requested the World Bank to provide non-lending technical assistance (NLTA) to provide high quality basic urban civic amenities to the residents of cities of Ludhiana and Amritsar in the areas of: water supply, sewerage, storm water drainage, solid waste management, and modern urban transport system. The study is expected to recommend measures and technologies to overcome the existing problems and transform the cities in to modern cities with substantially developed urban civic amenities. Capacity building, institution, and legal reforms will also be the component of the project report. After initial discussions with sector officials, a Bank team visited both Amritsar and Ludhiana cities to identify priority service level innovations and institutional challenges that have to be addressed under this NLTA for achieving desired transformative change. Currently, water supply is drawn from hundreds of unprotected bore wells across length and breadth of the city - which supply polluted water through an unplanned haphazard network. Utility, fully owned by the municipal corporation, will have operational autonomy to manage water and waste water services, whilst still be accountable to the corporation. Financial position will become clear, it can focus on becoming financially self-sustaining. The utility will make long term plans for water supply and sewage; and with government support may also be able to mobilize resources through this is unlikely in the short term in Amritsar.

From 2012 to 2014 water and sanitation service delivery assessments (SDA) have been carried out in seven selected countries in the East Asia and Pacific region under the guidance of the World Bank’s water and sanitation program and with valuable contributions of other development partners, such as United Nations Childrens Fund (UNICEF), WaterAid, and Asian Development Bank (ADB). Countries where SDA were carried out are Cambodia, Indonesia, Lao Peoples Democratic Republic (PDR), Papua New Guinea, Philippines, Timor-Leste, and Vietnam, while in Myanmar, a broad joint sector assessment took place by World Bank, UNICEF, ADB, and Japan International Cooperation Agency (JICA). SDA were implemented as a country-owned process led by key government agencies, and drew on the experience and methodology of similar assessments conducted in more than 40 countries (and states) in Africa, Latin America, and South Asia. It has three main components: a review of past water and sanitation access trends, a costing model to assess the adequacy of anticipated future investments, and a scorecard that allows diagnosis of bottlenecks along the service delivery pathways.

Bahaji, Abdellatif et al., Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. It is involved in glycolysis and in the regeneration of glucose-6-P molecules in the oxidative pentose phosphate pathway (OPPP). In chloroplasts of illuminated mesophyll cells PGI also connects the Calvin-Benson cycle with the starch biosynthetic pathway. In this work we isolated pgi1-3, a mutant totally lacking pPGI activity as a consequence of aberrant intron splicing of the pPGI encoding gene, PGI1. Starch content in pgi1-3 source leaves was ca. 10-15% of that of wild type (WT) leaves, which was similar to that of leaves of pgi1-2, a T-DNA insertion pPGI null mutant. Starch deficiency of pgi1 leaves could be reverted by the introduction of a sex1 null mutation impeding β-amylolytic starch breakdown. Although previous studies showed that starch granules of pgi1-2 leaves are restricted to both bundle sheath cells adjacent to the mesophyll and stomata guard cells, microscopy analyses carried out in this work revealed the presence of starch granules in the chloroplasts of pgi1-2 and pgi1-3 mesophyll cells. RT-PCR analyses showed high expression levels of plastidic and extra-plastidic β-amylase encoding genes in pgi1 leaves, which was accompanied by increased β-amylase activity. Both pgi1-2 and pgi1-3 mutants displayed slow growth and reduced photosynthetic capacity phenotypes even under continuous light conditions. Metabolic analyses revealed that the adenylate energy charge and the NAD(P)H/NAD(P) ratios in pgi1 leaves were lower than those of WT leaves. These analyses also revealed that the content of plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP)-pathway derived cytokinins (CKs) in pgi1 leaves were exceedingly lower than in WT leaves. Noteworthy, exogenous application of CKs largely reverted the low starch content phenotype of pgi1 leaves. The overall data show that pPGI is an important determinant of photosynthesis, energy status, growth and starch accumulation in mesophyll cells likely as a consequence of its involvement in the production of OPPP/glycolysis intermediates necessary for the synthesis of plastidic MEP-pathway derived hormones such as CKs., This work was partially supported by the Comisión Interministerial de Ciencia y Tecnología and Fondo Europeo de Desarrollo Regional (Spain) [grant numbers BIO2010-18239 and BIO2013-C2-1-P] and by the Government of Navarra [grant number IIM010491.RI1], the Ministry of Education, Youth and Sports of the Czech Republich [Grant L01204 from the National Program of Sustainability] and the European Social Fund and the state budget of the Czech Republic [project POST-UP, reg. No. CZ.1.07/2.3.00/30.0004]. AMS-L acknowledges a predoctoral fellowship from the Spanish Ministry of Science and Innovation. MB acknowledges a post-doctoral fellowship from the Public University of Navarra.

This synthesis report details the process, outputs and intermediate outcomes of the above technical assistance (TA) which was aimed at service delivery improvement in urban water and sanitation, especially to the urban poor, by: (i) supporting the government in establishing efficient, autonomous and responsive utility in Peshawar; (ii) facilitating the provincial/regional governments in formulation of water sector policies; (iii) designing demand based ‘Pakistan water sector technical advisory program’ for clients; and (iv) strengthening and aligning the urban (water) reform agenda in three provincial urban units through national urban forum.

To evaluate and reflect the sustainability of services in the region, an overall sector sustainability assessment was done taking into account four main dimensions: access to services, quality of services, efficiency of services, and financing of services. Each of these dimensions is measured through three simple and objective indicators. For each indicator, best practice values are established by looking at the best performers in the region, and the countries closest to those best performers are deemed to have a more mature sector. A more complete description of the methodology to assess sector sustainability is included in the annex of the state of the sector regional report from the Danube Water Program. The outcomes of this assessment for the Croatia water sector are displayed in Figure 9, which also shows average and best practices in the Danube region. The Croatian sector sustainability score is 72, which is above the Danube average sustainability of 64. The assessment shows that on average, the country performs well in terms of access to piped water and flush toilets, continuity of service, nonrevenue water and customer satisfaction. The main deficiencies of the Croatia water sector identified through the sector sustainability assessment are the wastewater treatment coverage and the operating cost ratio. The main challenges are: financing compliance with the European environmental acquis; ensuring affordability of future tariffs; implementing successfully the aggregation reform; and strengthening regulation in the water sector.

To evaluate and reflect the sustainability of services in the region, an overall sector maturity assessment was done taking into account four main dimensions: access to services, quality of services, efficiency of services, and financing of services. Each of these dimensions is measured through three simple and objective indicators. For each indicator, best practice values are established by looking at the best performers in the region, and countries closest to those best performers are deemed to have a more mature sector. A more complete description of the methodology to assess the sector maturity is included in the annex of the state of the sector regional report from the Danube Water Program. The outcomes of this assessment for the Austrian water sector are presented, which also shows average and best practices in the Danube region. The Austrian sector maturity score is 96, which is significantly higher than the Danube average maturity of 64, and the highest score in the region. The assessment shows that, on average, the country performs very well in terms of access to piped water and flushes toilet, wastewater treatment coverage, customer satisfaction, continuity of service, wastewater compliance, collection ratio, and nonrevenue water.

The Government of Kenya recognizes that the performance of the furniture sector is crucial both to employment and growth in the country. The Ministry of Industrialization and Enterprise Development (MOIED) therefore requested an analysis of both the furniture and timber sectors, in order to understand their current state of development, their main constraints, and the interventions necessary to accelerate their growth. The objective of this report is to provide a comprehensive value-chain analysis of the Kenyan furniture industry, including the timber sub-sector, in order to assess policy options available to the MOIED and recommend critical interventions to stimulate the industry’s development. By situating Kenya’s furniture industry within the global and regional context, this paper also aims to identify ways in which to boost Kenya’s competiveness in the East African markets and beyond. The analysis in this report is largely focused on the wooden furniture sector (versus plastics, composites, and other furniture). The bulk of Kenya’s furniture industry is focused on wood, and Kenya has a competitive advantage in wood relative to South Africa, Asian countries, and Europe, which have very competitive value chains in furniture made from other materials.

Industry affiliation provides an important channel through which trade liberalization can affect worker earnings and wage inequality between skilled and unskilled workers. This empirical study of the impact of the 1988-94 trade liberalization in Brazil on the industry wage structure suggests that although industry affiliation is an important component of worker earnings, the structure of industry wage premiums is relatively stable over time. There is no statistical association between changes in industry wage premiums and changes in trade policy or between industry-specific skill premiums to university graduates and trade policy. Thus trade liberalization in Brazil did not significantly contribute to increased wage inequality between skilled and unskilled workers through changes in industry wage premiums. The difference between these results and those obtained for other countries (such as Colombia and Mexico) provides fruitful ground for studying the conditions under which trade reforms do not have an adverse effect on industry wage differentials

It is often argued that the true benefits of water resource development in international river basins are undermined by a lack of consideration of interdependence in water resource planning. Yet it has not been adequately recognized in the water resources planning literature that overestimation of interdependence may also contribute to lack of progress in cooperation in many systems. This paper examines the nature and degree of economic interdependence in new and existing water storage projects in the Ganges River basin based on analysis conducted using the Ganges Economic Optimization Model. We find that constructing large dams on the upstream tributaries of the Ganges would have much more limited effects on controlling downstream floods than is thought and that the benefits of low-flow augmentation delivered by storage infrastructures are currently low. A better understanding of actual and prospective effects of interdependence not only changes the calculus of the benefits and costs of different scenarios of infrastructure development, but might also allow riparian countries to move closer to benefit sharing positions that are mutually acceptable.

Water, as a resource, is integral to human activities of all kinds. The water sector, as a society's means of ensuring individuals have sufficient water is fundamental to recovery and development. While designing and implementing water supply operations in any societal context is a complicated endeavor, doing so in contexts affected by conflict, fragility and violence is inherently associated with compounded challenges. The objective of this study is to summarize operational lessons from task teams to inform effective water supply and access operations in conflict-affected and fragile situations. This paper defines common operational challenges and describes actions that task teams have taken in Bank projects in order to address those challenges. Further, the paper explores ways to ensure that water supply projects in fragile and conflict-affected situations (FCS) contexts, in addition to achieving technical objectives, can also address perpetual causes of conflict and fragility. The risks of escalating violence and decreasing stability are exacerbated in situations where access to water resources and services is poor, constrained, inequitable, and unsustainable. This knowledge product summarizes lessons from World Bank task teams that have prepared and implemented water supply projects in locations affected by conflict, fragility and violence. The findings intend to support operational problem-solving during water operations that are conducted in these situations. The study engaged task team members and surveyed project documentation, consolidating data on contextual and operational challenges and responsive methods that staff recommend. The findings of this study show that clear priorities in process and organizational capacity, with a focus on access, are needed to ensure that water supply operations in FCS contexts are conflict-sensitive.

The report uses a theoretical model of a typical drainage basin, but the approach could be applied to many of the drainage basins managed by the holding company for water and wastewater in Egypt. This study set out to assess the relative health impacts of different wastewater management strategies on health in the Nile delta region using an approach similar to that used in the Ghana. The ultimate objective was to develop a framework for long-term investment planning based on monitoring of health and productivity impacts of proposed Bank operations which could be included in project Monitoring and Evaluation (M&E) systems. This will equip task teams to assess the risks and opportunities which arise due to the proposed shift from on-site to networked sanitation in four governorates where the Bank has wastewater operations. A secondary objective was to assess the extent to which existing legislation supports health riskbased planning. The conclusions of the study provide an indication of how such methods could increasingly be used to enable the selection of cost-effective and appropriate wastewater management strategies.

There is an urgent need to provide practical guidelines for Chinese decision makers and officials to better understand the key issues and constraints related to rural wastewater management and to identify feasible solutions and tools to improve the performance and sustainability of these projects. To address these needs, the World Bank has developed this guide for wastewater management in rural villages in China. The Guide is intended to be a useful resource for Chinese policy makers and practitioners. It includes a review of historical and current policies and practices related to wastewater management in rural China. The Guide outlines a framework and strategies for establishing municipal and village level wastewater management programs. The overall objective of the guide is to identify key issues and to present effective strategies and approaches to implement sustainable wastewater management programs at the local jurisdictions in order to improve rural sanitation in China. A key objective of the guide is to present institutional, programmatic and technical guidelines that can be adopted by local jurisdictions, forming the basis for consistent, affordable, practical, and effective sanitation project planning, design, implementation, and operations.

The objective of this report is to identify and evaluate best practices in smallholder private irrigation in West Africa. The report is based on a comparative assessment of the smallholder private irrigation subsector in Burkina Faso, Mali, Niger, and Nigeria, which included a literature review, field visits, and workshops at both national and regional levels. The task lists for the assessment is provided in annex one. This report first presents the main features of smallholder irrigation and the development projects that have promoted its use in West Africa in chapter two. The authors then describe the low-cost technologies available for this type of irrigation, including drilling, pumping, and water distribution in chapter three. Chapter four reviews the successes and remaining challenges of the development projects involving smallholder private irrigation in West Africa. Chapter five draws the lessons learned from these experiences and proposes recommendations for future investments, including more support to the development of a supply-chain for low-cost irrigation technologies, the adoption of a programmatic approach, and the necessity for a comprehensive investment package including environmental impact mitigation to sustainably support smallholder irrigators.

This paper provides an overview of major groundwater issues for Sub-Saharan Africa, with an assessment of their policy implications in terms of potential development and appropriate management. In terms of construction time, capital outlay and drought resilience, groundwater is the preferred source to meet most water-supply demands, despite hydro geological complexity, natural constraints on water well yields and quality, and institutional weaknesses. The 'new developmental agenda' relates to improving urban water-supply security and expanding irrigated agriculture to meet these challenges many countries need to undertake strategic assessment of their groundwater and prioritize investment on institutional strengthening so as to facilitate appropriately-managed groundwater development. Without effective use of available groundwater resources, improved livelihoods and climate-change adaptation will prove much more difficult to achieve.

The report looks critically at the water resources and the current and projected future water demands in the Southern Gobi Region (SGR) using the widely dispersed data and information that are currently available. An important conclusion of the report is that almost all the significant sources of groundwater in the SGR are 'fossil' or 'non-renewable', meaning that they are finite resources which cannot be replenished. Not only will that, but pumping water out of these fosil aquifers tend to cause a drop in the groundwater levels above them. The report proposes practical steps by which water resources development and management could be managed to best serve economic and infrastructure development while giving attention to environmental protection and service to communities in the SGR. The report also highlights the urgent need for more data. A more detailed picture of the distribution and quantity of the groundwater would give planners first, a better idea of both the limits to the growth of the SGR; and, second, of the future water demands, its spatial distribution, quality requirements, and the possibilities to increase water use efficiency and water re-use. Thus there is a need to bring all information and data together to form the basis for rational planning.

The aim of this paper is to provide a strategic overview of a decade of experience in supporting public administrations in their efforts to confront excessive groundwater resource exploitation for agricultural irrigation. Special emphasis is put on a series of on-the-ground pilot projects mainly in South and East Asia and Latin America, which are profiled through a series of boxes introduced in the paper. In these pilots' appropriate packages of technical, economic, institutional and social measures, in the main selected through use of a 'pragmatic framework' for groundwater resource management, have been introduced with agreement of stakeholders in an attempt to promote more sustainable groundwater use in agricultural irrigation. They have achieved varying degrees of success but do provide hope and orientation for the future in this important aspect of water resource management.

Governments and international development agencies have intensified efforts to promote small-scale enterprises as an engine of pro-poor growth. In Brazil, however, small scale industries may also be responsible for the bulk of air pollution emissions. Although employees of polluting small-scale industries in Brazil are not disproportionately poor, simulations suggest that stringent environmental regulation resulting in widespread closures of pollution-intensive small-scale industries would result in a non-negligible increase in poverty among employees of these firms. The results suggest that the enthusiasm for small-scale enterprises needs to be tempered by awareness of the potential environmental costs imposed by this sector.

In the late 1980s, Chile planned to privatize Santiago's sanitary works enterprise (EMOS) but instead reformed it under public ownership. It did so through a regulatory framework that mimicked the design of a concession with a private utility, setting tariffs that ensured at least a seven percent return on assets, creating a neutral regulator independent of ministry intervention, and giving EMOS the right to appeal the regulator's tariff decisions. This reform of Santiago's water system is often cited as a case of successful reform under public management. Comparing a comprehensive measure of welfare with a counterfactual example, the authors show surprisingly large gains from Santiago's reform, given the relatively good initial conditions. (The gains accrued largely to government and employees, but consumers benefited from improved service and coverage). Why did reform in Santiago improve water system performance, when similar reform attempts under public management in other countries failed? 1) Chile has a long tradition of private water rights, shaped by early recognition that water is a scarce and tradable private good. 2) The reformed regulatory framework was designed to attract private investors to the water system and to motivate them to operate efficiently and expand the system. 3) Chile's unique electoral institutions sustained this framework under state operation after democracy was restored. 4) Chile's strong bureaucratic norms and institutions (permitting little corruption), combined with Santiago's relatively low-cost water system, permitted prices that effectively increased quasi-rents for investing in the system while minimizing the risk of inefficiency or monopoly rents. The authors also address the question of why EMOS was reformed but not privatized, and what the costs of not privatizing were. The system was privatized in 1999, but the changes from privatization are likely to be less significant than those introduced in 1989-90.

An increasing number of regulators have adopted public disclosure programs to create incentives for pollution control. Previous empirical analyses of monitoring and enforcement issues have focused strictly on the impact of such traditional practices as monitoring (inspections) and enforcement (fines and penalties) on polluters' environmental performance. Other analyses have separately focused on the impact of public disclosure programs. But can these programs create incentives in addition to the normal incentives of fines and penalties? The authors study the impact of both traditional enforcement and information strategies in the context of a single program, to gain insights into the relative impact of traditional (fines and penalties) and emerging (public disclosure) enforcement strategies. Their results suggest that the public disclosure strategy adopted by the province of British Columbia, Canada, has a greater impact on both emission levels and compliance status than do orders, fines, and penalties traditionally imposed by the courts and the Ministry of the Environment. But their results also demonstrate that adopting stricter standards and higher penalties also significantly affected emission levels. Policymakers, take note: 1) The presence of strong, clear standards together with a significant, credible penalty system sends appropriate signals to the regulated community, which responds by lowering pollution emissions. 2) The public disclosure of environmental performance creates strong additional incentives to control pollution.