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2. Home Mechanical Ventilation in Children: Experience of Paediatric Pulmonology Divisions in Istanbul

Author

Yanaz, Muruvvet, primary, Unal, Fusun, additional, Hepkaya, Evrim, additional, Oksay, Sinem Can, additional, Köstereli, Ebru, additional, Yegit, Cansu Yilmaz, additional, Baskan, Azer Kilic, additional, Onay, Zeynep Reyhan, additional, Gulieva, Aynur, additional, Soyyigit, Aslınur, additional, Kalyoncu, Mine, additional, Kucuk, Hanife Busra, additional, Ayhan, Yetkin, additional, Ergenekon, Almala Pinar, additional, Atag, Emine, additional, Uzuner, Selcuk, additional, Ikizoglu, Nilay Bas, additional, Kilinc, Ayse Ayzit, additional, Ay, Pinar, additional, Eralp, Ela Erdem, additional, Gokdemir, Yasemin, additional, Oktem, Sedat, additional, Cakir, Erkan, additional, Girit, Saniye, additional, Uyan, Zeynep Seda, additional, Cokugras, Haluk, additional, Ersu, Refika, additional, Karadag, Bulent, additional, and Karakoc, Fazilet, additional

Published
2022
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3. Factors associated with pulmonary functions of cystic fibrosis (CF) patients in the National Cystic Fibrosis Patient Registry: a retrospective cohort study

Author

BAŞARAN, ABDURRAHMAN ERDEM, ÇAKIR, ERKAN, PEKCAN, SEVGİ, CİNEL, GÜZİN, SÜLEYMAN, AYŞE, KILIÇ, MEHMET, KORKMAZ EKREN, PERVİN, CAN, DEMET, ÇALTEPE, GÖNÜL, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, YÜKSEL, HASAN, BİLGİÇ ELTAN, SEVGİ, KESKİN, ÖZLEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, Eryımaz polat, Sanem, TUĞCU, GÖKÇEN DİLŞA, ÖZDEMİR, ALİ, HANGÜL, MELİH, KÖSE, MEHMET, HARMANCI, KORAY, ASFUROĞLU, PELİN, ASLAN, AYŞE TANA, SAPAN, NİHAT, ÖZÇELİK, HAYRİYE UĞUR, BİNGÖL, AYŞEN, KARTAL ÖZTÜRK, GÖKÇEN, DEMİR, ESEN, IRMAK, İLİM, DAMADOĞLU, EBRU, ÇAĞLAR, HANİFE TUĞÇE, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, TÜREL, ÖZDEN, YAZAN, HAKAN, HEPKAYA, EVRİM, KILIÇ BAŞKAN, AZER, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ALTINTAŞ, DERYA UFUK, ŞEN, VELAT, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, SERTÇELİK, AHMET, ÇAKIR, BANU, EMİRALİOĞLU, NAGEHAN, ÇOBANOĞLU, FATMA NAZAN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, and DOĞRU ERSÖZ, DENİZ

Abstract

We review the oscillator construction of the unitary representations ofnoncompact groups and supergroups and study the unitary supermultiplets ofOSp(1/32,R) in relation to M-theory. OSp(1/32,R) has a singleton supermultipletconsisting of a scalar and a spinor field. Parity invariance leads us toconsider OSp(1/32,R)_L X OSp(1/32,R)_R as the "minimal" generalized AdSsupersymmetry algebra of M-theory corresponding to the embedding of two spinorrepresentations of SO(10,2) in the fundamental representation of Sp(32,R). Thecontraction to the Poincare superalgebra with central charges proceeds via adiagonal subsupergroup OSp(1/32,R)_{L-R} which contains the common subgroupSO(10,1) of the two SO(10,2) factors. The parity invariant singletonsupermultiplet of OSp(1/32,R)_L \times OSp(1/32,R)_R decomposes into aninfinite set of "doubleton" supermultiplets of the diagonal OSp(1/32,R)_{L-R}. There is a unique "CPT self-conjugate" doubletonsupermultiplet whose tensor product with itself yields the "massless"generalized AdS_{11} supermultiplets. The massless graviton supermultipletcontains fields corresponding to those of 11-dimensional supergravity plusadditional ones. Assuming that an AdS phase of M-theory exists we argue thatthe doubleton field theory must be the holographic superconformal field theoryin ten dimensions that is dual to M-theory in the same sense as the dualitybetween the N=4 super Yang-Mills in d=4 and the IIB superstring over AdS_5 XS^5.

Published
2022

4. Comparisons of Clinical Features and Outcomes of COVID-19 between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children

Author

Haslak, Fatih, primary, Varol, Sevki Erdem, additional, Gunalp, Aybuke, additional, Kaynar, Ozge, additional, Yildiz, Mehmet, additional, Adrovic, Amra, additional, Sahin, Sezgin, additional, Kes, Gulsen, additional, Ayzit-Kilinc, Ayse, additional, Akdeniz, Beste, additional, Onal, Pinar, additional, Apaydin, Gozde, additional, Aygun, Deniz, additional, Arslan, Huseyin, additional, Kilic-Baskan, Azer, additional, Hepkaya, Evrim, additional, Meral, Ozge, additional, Barut, Kenan, additional, Cokugras, Haluk Cezmi, additional, and Kasapcopur, Ozgur, additional

Published
2022
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5. Ulusal Kistik Fibrozis Hasta Kayıt Sisteminde Yer Alan Altı Yaş Ve Üzeri Kistik Fibrozis Hastalarının Solunum Fonksiyonlarıyla İlişkili Faktörlerin İncelenmesi: Retrospektif Kohort Çalışması

Author

SAPAN, NİHAT, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, EMİRALİOĞLU, NAGEHAN, ÇAKIR, BANU, SERTÇELİK, AHMET, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, DOĞRU ERSÖZ, DENİZ, ŞEN, VELAT, ALTINTAŞ, DERYA UFUK, ÇOKUĞRAŞ, HALUK CEZMİ, KILINÇ, AYŞE AYZIT, KILIÇ BAŞKAN, AZER, ÖZÇELİK, HAYRİYE UĞUR, ÇAKIR, ERKAN, ÇOBANOĞLU, FATMA NAZAN, HEPKAYA, EVRİM, YAZAN, HAKAN, TÜREL, ÖZDEN, PEKCAN, SEVGİ, MOLLA KAFİ, HALE, TURKUT, ASLI İMRAN, ÜNAL, GÖKÇEN, CİNEL, GÜZİN, ÇAĞLAR, HANİFE TUĞÇE, SÜLEYMAN, AYŞE, KILIÇ, MEHMET, KORKMAZ EKREN, PERVİN, CAN, DEMET, ÇALTEPE, GÖNÜL, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, YÜKSEL, HASAN, DAMADOĞLU, EBRU, IRMAK, İLİM, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, BİLGİÇ ELTAN, SEVGİ, KESKİN, ÖZLEM, BİNGÖL, AYŞEN, BAŞARAN, ABDURRAHMAN ERDEM, ASLAN, AYŞE TANA, ASFUROĞLU, PELİN, HARMANCI, KORAY, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, KÖSE, MEHMET, HANGÜL, MELİH, ÖZDEMİR, ALİ, Eryımaz polat, Sanem, and TUĞCU, GÖKÇEN DİLŞA

Published
2021

6. Ülkemizde Kistik Fibrozis Yönetiminde Merkezler Arası Farklılıkların Değerlendirilmesi veUluslararası Kayıt Sistemleri ile Karşılaştırılması

Author

ASFUROĞLU, PELİN, ÖZDOĞAN, ŞEBNEM, ÖZDEMİR, ALİ, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, YAZAN, HAKAN, ÇAKIR, ERKAN, MOLLA KAFİ, HALE, TOPRAK, ALİ, EMİRALİOĞLU, NAGEHAN, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, Karadağ, Bülent, GÖKDEMİR, YASEMİN, ERDEM ERALP, ELA, ŞEN, VELAT, TURKUT, ASLI İMRAN, ÜNAL, GÖKÇEN, ÇAĞLAR, HANİFE TUĞÇE, ÇOKUĞRAŞ, HALUK CEZMİ, KILINÇ, AYŞE AYZIT, KILIÇ BAŞKAN, AZER, HEPKAYA, EVRİM, ALTINTAŞ, DERYA UFUK, ÖZCAN, DİLEK, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, BAŞARAN, ABDURRAHMAN ERDEM, BİNGÖL, AYŞEN, SAPAN, NİHAT, ÇEKİÇ, ŞÜKRÜ, DAMADOĞLU, EBRU, IRMAK, İLİM, ASLAN, AYŞE TANA, TUĞCU, GÖKÇEN DİLŞA, Eryımaz polat, Sanem, HARMANCI, KORAY, KÖSE, MEHMET, HANGÜL, MELİH, SÜLEYMAN, AYŞE, YÜKSEL, HASAN, KESKİN, ÖZLEM, ÖZCAN, GİZEM, TOPAL, ERDEM, CAN, DEMET, KORKMAZ EKREN, PERVİN, ÇALTEPE, GÖNÜL, KILIÇ, MEHMET, PEKCAN, SEVGİ, ÇOBANOĞLU, FATMA NAZAN, ÖZÇELİK, HAYRİYE UĞUR, and DOĞRU ERSÖZ, DENİZ

Published
2021

7. Covıd-19 Enfeksiyonu Geçiren Çocuklarda İzlemde Solunum Fonksiyonlarının Değerlendirilmesi, Klinik Ve Laboratuvar Bulguları İle Karşılaştırılması

Author

TEZER, HASAN, Akyan Soydaş, Şule Selin, HEPKAYA, EVRİM, TAPISIZ, ANIL, GİRİT, SANİYE, BEKEN, BURÇİN, ATAĞ, EMİNE, ASLAN, AYŞE TANA, VEZİR, EMİNE, Eryılmaz Polat, Sanem, HIZAL, MİNA, GÖKDEMİR, YASEMİN, ARSLAN, HÜSEYİN, AYHAN, YETKİN, BESLİ, GÜLSEREN ESEN, TUĞCU, GÖKÇEN DİLŞA, ÇAKIR, ERKAN, PEKCAN, SEVGİ, ÜNAL, GÖKÇEN, CİNEL, GÜZİN, TURKUT, ASLI İMRAN, UYTUN, SALİH, OCAK, ECE, METİN AKCAN, ÖZGE, KARTAL ÖZTÜRK, GÖKÇEN, Gençoğlu, Murat Yasin, ÖNAL, PINAR, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, ÖZKAN TABAKÇI, SATI, ERDEM ERALP, ELA, OKTEM, SEDAT, TÜREL, ÖZDEN, YAZAN, HAKAN, Bursal Durmaz, Burcu, ÖCAL DEMİR, SEVLİYA, BEDİR DEMİRDAĞ, TUĞBA, Karadağ, Bülent, KILINÇ, AYŞE AYZIT, and ÇOKUĞRAŞ, HALUK CEZMİ

Published
2021

8. Ülkemizde Kistik Fibrozis Yönetiminde Merkezler Arası Farklılıkların Değerlendirilmesi ve Uluslararası Kayıt Sistemleri ile Karşılaştırılması

Author

ASFUROĞLU, PELİN, ÖZDOĞAN, ŞEBNEM, BAŞARAN, ABDURRAHMAN ERDEM, ÖZCAN, DİLEK, BİNGÖL, AYŞEN, ALTINTAŞ, DERYA UFUK, HEPKAYA, EVRİM, SAPAN, NİHAT, ÇEKİÇ, ŞÜKRÜ, DAMADOĞLU, EBRU, IRMAK, İLİM, ERYILMAZ POLAT, SANEM, TUĞCU, GÖKÇEN DİLŞA, ÖZDEMİR, aLİ, HARMANCI, KORAY, KILIÇ BAŞKAN, AZER, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ÇAĞLAR, HANİFE, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, ŞEN, VELAT, ERDEM ERALP, ELA, GÖKDEMİR, YASEMİN, KARADAĞ, BÜLENT TANER, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, EMİRALİOĞLU, NAGEHAN, TOPRAK, ALİ, MOLLA KAFİ, HALE, ÇAKIR, ERKAN, YAZAN, HAKAN, ASLAN, AYŞE TANA, KÖSE, MEHMET, HANGÜL, MELİH, SÜLEYMAN, AYŞE, YÜKSEL, HASAN, KESKİN, ÖZLEM, ÖZCAN, GİZEM, TOPAL, ERDEM, CAN, DEMET, KORKMAZ EKREN, PERVİN, ÇALTEPE, GÖNÜL, KILIÇ, MEHMET, DEMİR, ESEN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, PEKCAN, SEVGİ, ÇOBANOĞLU, FATMA NAZAN, ÖZÇELİK, HAYRİYE UĞUR, DOĞRU ERSÖZ, DENİZ, and KARTAL ÖZTÜRK, GÖKÇEN

Published
2021

10. Efficacy of standardized tracheostomy training with a simulation model for healthcare providers: A study by ISPAT team

Author

Uyan, Zeynep S., primary, Atag, Emine, additional, Ergenekon, Almala P., additional, Gokdemir, Yasemin, additional, Gokler, Ozan, additional, Ay, Pinar, additional, Bas İkizoglu, Nilay, additional, Cenk, Muruvvet, additional, Erdem Eralp, Ela, additional, Sivrikaya, G. Ulufer, additional, Girit, Saniye, additional, Cakir, Erkan, additional, Kilic, Ayse A., additional, Yazan, Hakan, additional, Can Oksay, Sinem, additional, Hepkaya, Evrim, additional, Kiyan, Gursu, additional, Karadag, Bulent, additional, Karakoc, Fazilet, additional, and Oktem, Sedat, additional

Published
2021
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13. Effect of standardized hands-on-training in caregivers of children with tracheostomy

Author

Yegit, Cansu Yilmaz, primary, Kilinc, Ayse Ayzit, additional, Gulieva, Aynur, additional, Atag, Emine, additional, Yazan, Hakan, additional, Can Oksay, Sinem, additional, Kostereli, Ebru, additional, Uzuner, Selcuk, additional, Onay, Zeynep Reyhan, additional, Hepkaya, Evrim, additional, Ergenekon, Almala Pinar, additional, Kalyoncu, Mine, additional, Unal, Fusun, additional, Mavi, Deniz, additional, Ayhan, Yetkin, additional, Collak, Abdulhamit, additional, Cenk, Muruvvet, additional, Arslan, Huseyin, additional, Baskan, Azer Kilic, additional, Bilgin, Gulay, additional, Bas Ikızoglu, Nilay, additional, Ay, Pinar, additional, Oktem, Sedat, additional, Gokdemir, Yasemin, additional, Uyan, Zeynep Seda, additional, Cakir, Erkan, additional, Girit, Saniye, additional, Cokugras, Haluk, additional, Karadag, Bulent, additional, Karakoc, Fazilet, additional, and Erdem Eralp, Ela, additional

Published
2021
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14. The effect of training the health care providers with simulation model on the care of patients with chronic tracheostomy

Author

Uyan, Zeynep Seda, primary, Atag, Emine, additional, Ergenekon, Almala Pınar, additional, Gökdemir, Yasemin, additional, Gökler, Ozan, additional, Ay, Pınar, additional, Baş İkizoğlu, Nilay, additional, Cenk, Mürüvvet, additional, Erdem Eralp, Ela, additional, Sivrikaya, Ulufer, additional, Girit, Saniye, additional, Çakır, Erkan, additional, Kılıç, Ayşe Ayzıt, additional, Yazan, Hakan, additional, Can Oksay, Sinem, additional, Hepkaya, Evrim, additional, Karadağ, Bülent, additional, Karakoç, Fazilet, additional, and Öktem, Sedat, additional

Published
2021
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16. The Role of Telehealth Services in Children with Cystic Fibrosis During Coronavirus Disease 2019 Outbreak.

Author

Beşer, Ömer Faruk, Karaboğa, Ebru Pelin Uğur, Hepkaya, Evrim, Kılınç Sakallı, Ayşe Ayzıt, Dönmez Türkmen, Ahsen, Dilek, Tuğçe Damla, Çokuğraş, Haluk, and Çullu Çokuğraş, Fügen

Subjects
COVID-19, MIDDLE East respiratory syndrome, CYSTIC fibrosis, CORONAVIRUS diseases, CHILD services, MEDICAL care, DISEASE outbreaks, SARS-CoV-2
Abstract

Objectives:This study aimed to monitor the health and nutritional status of pediatric cystic fibrosis (CF) patients via telehealth services during the novel coronavirus disease 2019 (COVID-19). Additional aims were to determine the level of anxiety in the patients and their caregivers and to determine the COVID-19 transmission status among CF patients. Materials and Methods:The CF team supported the patients via remote contact. During telehealth services interviews, in addition to obtaining information about the patients' anthropometric measurements, health status, and CF-related complaints, the State-Trait Anxiety Inventory (STAI) was administered to the patients and controls. The Hospital Anxiety and Depression Scale (HAD) was administered to their caregivers. Results:The study included 144 pediatric CF patients (74 males and 70 females). Mean age of the patients was 8.9 years. In all, 42 (29.2%) of the patients were tested for COVID-19, of which 4 were positive. The mean STAI score was significantly lower in the patient group than in the control group (p < 0.001). The mean HAD anxiety score was significantly higher in the caregivers of the CF patients, compared to the caregivers of the controls (p = 0.005). In addition, the mean HAD depression score was significantly higher in the caregivers of the CF patients (p < 0.001). Conclusions:Telehealth is an innovative method for providing health care services while maintaining social distance and avoiding the risk of exposure and spread of COVID-19. Telehealth services reduce patient and parental anxiety and increase the level of confidence in managing CF-related complications. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Efficacy of standardized tracheostomy training with a simulation model for healthcare providers: A study by ISPAT team.

Author

Uyan, Zeynep S., Atag, Emine, Ergenekon, Almala P., Gokdemir, Yasemin, Gokler, Ozan, Ay, Pinar, Bas İkizoglu, Nilay, Cenk, Muruvvet, Erdem Eralp, Ela, Sivrikaya, G. Ulufer, Girit, Saniye, Cakir, Erkan, Kilic, Ayse A., Yazan, Hakan, Can Oksay, Sinem, Hepkaya, Evrim, Kiyan, Gursu, Karadag, Bulent, Karakoc, Fazilet, and Oktem, Sedat

Published
2022
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20. Factors associated with pulmonary function decline of patients in the cystic fibrosis registry of Turkey: A retrospective cohort study.

Author

Emiralioğlu N, Çakır B, Sertçelik A, Yalçın E, Kiper N, Şen V, Altıntaş DU, Serbes M, Çokuğraş H, Kılınç AA, Başkan AK, Hepkaya E, Yazan H, Türel Ö, Kafi HM, Yılmaz Aİ, Ünal G, Çağlar T, Damadoğlu E, Irmak İ, Demir E, Öztürk G, Bingöl A, Başaran E, Sapan N, Aslan AT, Asfuroğlu P, Harmancı K, Köse M, Hangül M, Özdemir A, Tuğcu G, Polat SE, Özcan G, Gayretli ZG, Keskin Ö, Bilgiç S, Yüksel H, Özdoğan Ş, Topal E, Çaltepe G, Can D, Ekren PK, Kılıç M, Süleyman A, Eyüboğlu TŞ, Cinel G, Pekcan S, Çobanoğlu N, Çakır E, Özçelik U, and Doğru D

Subjects
Humans, Retrospective Studies, Male, Female, Child, Adolescent, Forced Expiratory Volume, Turkey epidemiology, Risk Factors, Young Adult, Adult, Pseudomonas Infections epidemiology, Pseudomonas Infections physiopathology, Lung physiopathology, Severity of Illness Index, Pseudomonas aeruginosa, Cystic Fibrosis physiopathology, Registries, Disease Progression, Respiratory Function Tests statistics & numerical data
Abstract

Background: The decline in pulmonary function is a predictor of disease progression in patients with cystic fibrosis (CF). This study aimed to determine the decline rate of percent predicted forced expiratory volume in 1 s (ppFEV1) based on the data of the CF Registry of Turkey. The secondary aim was to investigate the risk factors related to the decline in ppFEV1., Methods: A retrospective cohort study of CF patients over 6 years old, with pulmonary function data over at least 2 years of follow-up was extracted from the national CF registry for years 2017-2019. Patients were classified according to disease severity and age groups. Multivariate analysis was used to predict the decline in ppFEV1 and to investigate the associated risk factors., Results: A total of 1722 pulmonary function test results were available from 574 patients over the study period. Mean diagnostic age was older and weight for age, height for age, and body mass index z scores were significantly lower in the group of ppFEV1 < 40, while chronic Pseudomonas aeruginosa (p < .001) and mucoid P. aeruginosa colonization (p < .001) were significantly higher in this group (p < .001). Overall mean annual ppFEV1 decline was -0.97% (95% confidence interval [CI] = -0.02 to -1.92%). The mean change of ppFEV1 was significantly higher in the group with ppFEV1 ≥ 70 compared with the other (ppFEV1 < 40 and ppFEV1: 40-69) two groups (p = .004). Chronic P. aeruginosa colonization (odds ratio [OR] = 1.79 95% CI = 1.26-2.54; p = .01) and initial ppFEV1 ≥ 70 (OR = 2.98 95% CI = 1.06-8.36), p = .038) were associated with significant ppFEV1 decline in the whole cohort., Conclusions: This data analysis recommends close follow-up of patients with normal initial ppFEV1 levels at baseline; advocates for early interventions for P. aeruginosa; and underlines the importance of nutritional interventions to slow down lung disease progression., (© 2024 Wiley Periodicals LLC.)

Published
2024
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21. The Role of Telehealth Services in Children with Cystic Fibrosis During Coronavirus Disease 2019 Outbreak.

Author

Beşer ÖF, Karaboğa EPU, Hepkaya E, Kılınç Sakallı AA, Dönmez Türkmen A, Dilek TD, Çokuğraş H, and Çullu Çokuğraş F

Subjects
Anxiety epidemiology, Child, Disease Outbreaks, Female, Humans, Male, COVID-19 epidemiology, Cystic Fibrosis epidemiology, Cystic Fibrosis therapy, Telemedicine
Abstract

Objectives: This study aimed to monitor the health and nutritional status of pediatric cystic fibrosis (CF) patients via telehealth services during the novel coronavirus disease 2019 (COVID-19). Additional aims were to determine the level of anxiety in the patients and their caregivers and to determine the COVID-19 transmission status among CF patients. Materials and Methods: The CF team supported the patients via remote contact. During telehealth services interviews, in addition to obtaining information about the patients' anthropometric measurements, health status, and CF-related complaints, the State-Trait Anxiety Inventory (STAI) was administered to the patients and controls. The Hospital Anxiety and Depression Scale (HAD) was administered to their caregivers. Results: The study included 144 pediatric CF patients (74 males and 70 females). Mean age of the patients was 8.9 years. In all, 42 (29.2%) of the patients were tested for COVID-19, of which 4 were positive. The mean STAI score was significantly lower in the patient group than in the control group ( p < 0.001). The mean HAD anxiety score was significantly higher in the caregivers of the CF patients, compared to the caregivers of the controls ( p  = 0.005). In addition, the mean HAD depression score was significantly higher in the caregivers of the CF patients ( p < 0.001). Conclusions: Telehealth is an innovative method for providing health care services while maintaining social distance and avoiding the risk of exposure and spread of COVID-19. Telehealth services reduce patient and parental anxiety and increase the level of confidence in managing CF-related complications.

Published
2022
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22. Immunomodulator effect of topical zinc oxide application in tuberculin skin test.

Author

Nuhoglu C, Hepkaya E, Onal ZE, Akici N, Gurbuz T, Atasayan V, and Ceran O

Abstract

Objective: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability., Methods: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later., Results: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels., Conclusion: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.

Published
2018
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