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Background Traditional Chinese medicine (TCM) has become an important option for patients with advanced esophageal cancer (EC) who are not able to undergo surgery, radiotherapy, chemotherapy, or with disease progression after chemotherapy. The purpose of this study is to investigate the application effects of Dingxiang Guanshitong Hanhua Pills alone and its combination with Fugui Guanshitong Granules, in order to improve the quality of life of patients with advanced EC, and provide an effective TCM treatment schemes for EC. Objective To evaluate the effects of Dingxiang Guanshitong Hanhua Pills alone and its combination with Fugui Guanshitong Granules on survival rate and quality of life of patients with EC after 6 weeks of treatment. Methods A total of 109 patients with advanced EC admitted to nine centers such as the First Affiliated Hospital of Henan University of CM, Linzhou Hospital of Traditional Chinese Medicine and Jia County Hospital of Traditional Chinese Medicine from January 2020 to April 2021 were selected as the research objects and divided into the control group, experimental group 1 and experimental group 2 by block randomization method. The control group received Danggui Buxue Decoction and Guizhi Renshen Decoction Granules, the experimental group 1 received Fugui Guanshitong Granules and Dingxiang Guanshitong Hanhua Pills, the experimental group 2 received Dingxiang Guanshitong Hanhua Pills, with the course of 6 weeks in the above three groups. The survival rate after 6 weeks of treatment, Quality of Life (QOL) score, Karnofsky Performance Status (KPS) score, TCM syndrome score (dysphagia, poststernal chest pain, mucus vomiting, loss of appetite, fatigue) before and after treatment of the three groups were compared, and safety evaluation was conducted. Results After 6 weeks of treatment, the survival rate was 72.7% in the control group, 88.6% in the experimental group 1, and 86.8% in the experimental group 2, and there was no statistically significant difference in the survival rates among the three groups after 6 weeks of treatment (χ2=4.036, P=0.133). There was no interaction effect of group and time on QOL score, KPS score, and TCM syndrome score (Pinteraction>0.05). The main effect of group was not significant on QOL score, KPS score and TCM syndrome score (Pinterclass>0.05). The main effect of time was significant on QOL score, KPS score and TCM syndrome score (Ptime

Based on the same bis(4-piperidine) phenyl derivative donor, isophorone derivative bridge, and phenyl trifluoromethyl tricyclofuran (3F-TCF) acceptor, two different isolating groups, tert butyldimethylsilyl (TBDMS) and pentafluorophenyl ring (5F-Ph), were introduced into the donor and bridge to synthesize two chromophores XY 1-2. Eight 5F-Ph groups are respectively attached to the donor and bridge segments of the chromophore, which can prevent the molecules from tightly packing and thus improve polarization efficiency. This article systematically investigates the UV absorption, density functional theory (DFT) calculations, thermal stability, and electro-optic activity of these chromophores. The chromophores XY 1-2 exhibit good thermal stability at decomposition temperatures (Td) greater than 250 °C. Most importantly, rigid steric hindrance groups can effectively reduce dipole–dipole interactions between molecules and improve the conversion efficiency of the first-order hyperpolarization (β) of chromophores into large electro-optic (EO) coefficients (r33). And the poling efficiency of a single XY2 molecule at 1310 nm (0.69 ± 0.01 nm2 V−2/(1020 molecules per cm3)) is much higher than that of a single XY1 molecule when polarizing the polymer with chromophore XY 1-2. [ABSTRACT FROM AUTHOR]

AbstractSeismic uplift of a high-speed rail (HSR) cable-stayed bridge’s bearing affects train safety. Existing technique lacks improved seismic isolation in the vertical direction due to the bearing’s vertical stiffness. Based on the on-site dynamic test and train derailment table experiments and different software, the train running safety of the semi-floating system of the cable-stayed bridge-rail-train system was analyzed using different damping and isolation control strategies. The larger vertical seismic component increases the danger of flange climb derailment when subjected to near-fault earthquakes. After installing lateral/or viscous fluid dampers (VFDs) and magnetorheological (MR) bearing (A = 3.0), the bridge has an obvious bearing uplift response. Still, it is not enough to threaten the structure, and the seismic damping capacity of the bridge structure is improved, making the train ride safe. This research presents discoveries on the impact of bearing uplift on train operational safety. Specifically, it reveals that the lifting of the end bearings on both sides of the main girder is not synchronized. This investigation presents a technical reference for comparable initiatives. [ABSTRACT FROM AUTHOR]

Due to the suitable bandgap structure, efficient conversion rates of photon to electron, adjustable optical bandgap, high electron mobility/aspect ratio, low defects, and outstanding optical and electrical properties for device design, III–V semiconductors have shown excellent properties for optoelectronic applications, including photodiodes, photodetectors, solar cells, photocatalysis, etc. In particular, III–V nanostructures have attracted considerable interest as a promising photodetector platform, where high-performance photodetectors can be achieved based on the geometry-related light absorption and carrier transport properties of III–V materials. However, the detection ranges from Ultraviolet to Terahertz including broadband photodetectors of III–V semiconductors still have not been more broadly development despite significant efforts to obtain the high performance of III–V semiconductors. Therefore, the recent development of III–V photodetectors in a broad detection range from Ultraviolet to Terahertz, and future requirements are highly desired. In this review, the recent development of photodetectors based on III–V semiconductor with different detection range is discussed. First, the bandgap of III–V materials and synthesis methods of III–V nanostructures are explored, subsequently, the detection mechanism and key figures-of-merit for the photodetectors are introduced, and then the device performance and emerging applications of photodetectors are provided. Lastly, the challenges and future research directions of III–V materials for photodetectors are presented. [ABSTRACT FROM AUTHOR]

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A novel, highly efficient terahertz fully polarized transmission line is designed by two-dimensional tellurium photonic crystals consisting of square lattice rod arrays with a complete photonic bandgap. The TE and TM photonic bandgaps of the tellurium photonic crystals, which are computed by plane wave expansion, happen to coincide, and the complete photonic bandgap covers from 2.894 to 3.025 THz. The function of the designed waveguide is simulated by the finite element method, and the transmission characteristics are optimized by accurately adjusting its structural parameters. The transmission efficiency of the waveguide for TE mode achieves a peak value of −0.34 dB at a central frequency of 2.950 THz and keeps above −3 dB from 2.82 THz to 3.02 THz, obtaining a broad relative bandwidth of about 6.84 percent. The operating bandwidth of the tellurium photonic crystals' waveguide for TM mode is narrower than that of TE mode, whose relative bandwidth is about 4.39 percent or around 2.936 THz above −5 dB. The designed terahertz photonic crystals' waveguide can transmit both TE and TM waves, and not only can it be used as a high-efficiency transmission line, but it also provides a promising approach for implementing fully polarized THz devices for future 6G communication systems. [ABSTRACT FROM AUTHOR]

A novel terahertz polarization isolator using a two-dimensional square lattice tellurium rod array is numerically investigated at the interesting band of 0.22 THz in this short paper. The isolator is designed by inserting six hexagonal tellurium rods into a fully polarized photonic crystals waveguide with high efficiency of −0.34 dB. The TE and TM photonic band gaps of the 7 × 16 tellurium photonic crystals are computed based on the plane wave expansion method, which happen to coincide at the normalized frequency domain from 0.3859(a/λ) to 0.4033(a/λ), corresponding to the frequency domain from 0.2152 to 0.2249 THz. The operating bandwidth of the tellurium photonic crystals waveguide covers 0.2146 to 0.2247 THz, calculated by the finite element method. The six hexagonal tellurium rods with smaller circumradii of 0.16a serve to isolate transverse electric waves and turn a blind eye to transverse magnetic waves. The polarization isolation function and external characteristic curves of the envisaged structure are numerically simulated, which achieves the highest isolation of −33.49 dB at the central frequency of 0.2104 THz and the maximum reflection efficiency of 98.95 percent at the frequency of 0.2141 THz. The designed isolator with a unique function and high performance provides a promising approach for implementing fully polarized THz devices for future 6G communication systems. [ABSTRACT FROM AUTHOR]