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We investigate the effects of site response on source parameter estimates using earthquakes recorded by the LArge-n Seismic Survey in Oklahoma (LASSO). While it is well known that near-surface unconsolidated sediments can cause an apparent breakdown of earthquake self-similarity, the influence of laterally varying site conditions remains unclear. We analyze site conditions across the 1825-station array on a river plain within an area of 40 km by 23 km using vertical ground motions from 14 regional earthquakes. While the source radiation pattern controls P-wave ground motions below 8 Hz, the surface geology correlates with P-wave ground motions above 8 Hz and S-wave ground motions at 2–21 Hz. Stations installed in alluvial sediments have vertical ground motions that can exceed three times the array median. We use the variation of ground motion of regional earthquakes across the array as a proxy for site effects. The corner frequencies and stress drops of local earthquakes (ML = 0.01–3) estimated using a standard single-spectra approach show negative correlations with the site-effect proxy, while the seismic moments show positive correlations. In contrast, the spectral-ratio approach effectively shows no correlation. The overall bias is small as expected for this relatively homogeneous structure; accurate estimation of site-related biases requires at least 30 stations. Correcting for site-related biases reduces the standard deviations of the source parameters by less than 13% of the total variations. Remaining variations are partially associated with source directivity and model misfits— as small earthquakes can have complex ruptures.

ObjectiveTo examine associations between prenatal use of selective serotonin reuptake inhibitors (SSRIs) and the odds of autism spectrum disorders (ASDs) and other developmental delays (DDs).MethodsA total of 966 mother-child pairs were evaluated (492 ASD, 154 DD, 320 typical development [TD]) from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study, a population-based case-control study. Standardized measures confirmed developmental status. Interviews with biological mothers ascertained prenatal SSRI use, maternal mental health history, and sociodemographic information.ResultsOverall, prevalence of prenatal SSRI exposure was lowest in TD children (3.4%) but did not differ significantly from ASD (5.9%) or DD (5.2%) children. Among boys, prenatal SSRI exposure was nearly 3 times as likely in children with ASD relative to TD (adjusted odds ratio [OR]: 2.91; 95% confidence interval [CI]: 1.07-7.93); the strongest association occurred with first-trimester exposure (OR: 3.22; 95% CI: 1.17-8.84). Exposure was also elevated among boys with DD (OR: 3.39; 95% CI: 0.98-11.75) and was strongest in the third trimester (OR: 4.98; 95% CI: 1.20-20.62). Findings were similar among mothers with an anxiety or mood disorder history.ConclusionsIn boys, prenatal exposure to SSRIs may increase susceptibility to ASD or DD. Findings from published studies on SSRIs and ASD continues to be inconsistent. Potential recall bias and residual confounding by indication are concerns. Larger samples are needed to replicate DD results. Because maternal depression itself carries risks for the fetus, the benefits of prenatal SSRI use should be carefully weighed against potential harms.

The Social Communication Questionnaire is one of the most commonly used screening tools for autism spectrum disorder. The Social Communication Questionnaire is a caregiver-reported questionnaire with 40 items based on questions from the Autism Diagnostic Interview-Revised. This study collected Social Communication Questionnaire data from a community-based, multi-stage case identification design epidemiologic study in one socioeconomically disadvantaged county in Taiwan. The Social Communication Questionnaire was distributed to 3034 school children, aged 6-8 years. Item prevalence results indicate males were reported to have more autism-related behaviors than females (higher prevalence on most items), in the whole study sample as well as in children meeting Social Communication Questionnaire clinical cut-offs (?15). Children whose biological fathers completed the Social Communication Questionnaire were reported to have more behavioral issues than children whose biological mothers were the respondent. Lower respondent education levels were associated with reports of clinically concerning autism-related behaviors. However, males were not at higher risk of meeting Social Communication Questionnaire clinical cut-offs than females in this study population. Findings from this study help to better understand reporting patterns on children's autism-related behaviors potentially due to social demographic characteristics and child sex, which may lead to improved identification of these behaviors.

Utilizing surveillance data from five sites participating in the Autism and Developmental Disabilities Monitoring Network, we investigated contributions of surveillance subject and census tract population sociodemographic characteristics on variation in autism spectrum disorder ascertainment and prevalence estimates from 2000 to 2008 using ordinal hierarchical models for 2489 tracts. Multivariable analyses showed a significant increase in ascertainment of autism spectrum disorder cases through both school and health sources, the optimal ascertainment scenario, for cases with college-educated mothers (adjusted odds ratio = 1.06, 95% confidence interval = 1.02-1.09). Results from our examination of sociodemographic factors of tract populations from which cases were drawn also showed that after controlling for other covariates, statistical significance remained for associations between optimal ascertainment and percentage of Hispanic residents (adjusted odds ratio = 0.93, 95% confidence interval = 0.88-0.99) and percentage of residents with at least a bachelor's degree (adjusted odds ratio = 1.06, 95% confidence interval = 1.01-1.11). We identified sociodemographic factors associated with autism spectrum disorder prevalence estimates including race, ethnicity, education, and income. Determining which specific factors influence disparities is complicated; however, it appears that even in the presence of education, racial and ethnic disparities are still apparent. These results suggest disparities in access to autism spectrum disorder assessments and special education for autism spectrum disorder among ethnic groups may impact subsequent surveillance.

The success of deep geothermal systems depends on the presence of fault zones in the subsurface. Faults play a vital role in the Earth’s plumbing system by facilitating fluid flow when they dilate, but are simultaneously known to enhance the hazard of the system once slipping in shear mode. As dilation of a fault enhances its permeability significantly, shear failure can lead to loss of boreholes or seismic events of economic concern. In this study, we present the evolution of reactivation potential of major faults during 25-year production period in deep generic geothermal systems in the greater Ruhr region in western Germany. To determine the pre-operational in situ stress state we use a recently published comprehensive dataset of stress magnitude data from the greater Ruhr region in an analytical-probabilistic model accounting for uncertainties of in situ stress, fault geometry, and frictional properties for a prospective reservoir in the Devonian Massenkalk formations. The resulting cumulative distribution functions of dilation and slip tendency of given fault sets suggests that more than half of the combined length of NW-SE-striking faults have a high reactivation probability, whereas the NE-SW-striking faults remain not optimally-oriented in the regional stress field. Using the relationship between dilation and slip tendency, we propose fault segments suitable for geothermal development that exhibit high hydraulic conductivity, i.e. high dilation tendency, and lower potential for shear failure, i.e. low slip tendency. In the second step, we employ generic thermo-hydro-mechanical models to quantify induced spatio-temporal stress changes on selected fault planes due to long-term geothermal production. We find that after 25 years thermal stress changes contribute significantly to the change of the reactivation potential which should be accounted for while planning deep geothermal systems. [ABSTRACT FROM AUTHOR]

Passive seismic analyses are a key technology for the exploration and monitoring of subsurface reservoirs. Searching for alternative resources in the framework of the energy transition is creating a surge for identifying as many potential sites as possible suitable for geothermal exploitation. The Lower Rhine Embayment, at the western border of North Rhine-Westphalia in Germany, is an extensional system with a very high potential for geothermal exploitation. The area experiences moderate but continuous natural seismicity. Here, we report on a passive seismic dataset recorded with 48 seismic stations centred at and around Eschweiler–Weisweiler (10.14470/MO7576467356, Finger et al., 2022). Background seismic noise levels are high at this site due to high levels of anthropogenic noise and thick unconsolidated sedimentary layers. The final station layout is a compromise between targeted network design and suitably quiet locations. We show that the network design allows for the application of state-of-the-art methods including waveform-based source location methods and ambient-noise velocity imaging methods. [ABSTRACT FROM AUTHOR]

Past research has shown that children with autism and their families have compromised quality of life (QOL) in several domains. This study examined QOL and parental concerns in children with autism during early childhood, childhood, and adolescence compared to children with Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) and to typical controls from a US national sample. Families with children diagnosed with autism reported more profound QOL effects than families of children with ADD/ADHD or unaffected controls. Children with autism were significantly less likely to attend religious services, more likely to miss school, and less likely to participate in organized activities. Parental concerns over learning difficulty, being bullied, stress-coping, and achievement were overwhelming in the autism group relative to the comparison groups.

The objective of this study was to examine injury risk in children with autism, ADD/ADD, learning disability, psychopathology, or other medical conditions. Children aged 3-5 years who participated in the National Survey of Children's Health were included. Six study groups were analyzed in this report: autism (n=82), ADD/ADHD (n=191), learning disability (n=307), psychopathology (n=210), other medical conditions (n=1802), and unaffected controls (n=13,398). The weighted prevalence of injury in each group was 24.2% (autism), 26.5% (ADD/ADHD), 9.3% (learning disability), 20.5% (psychopathology), 14.6% (other medical conditions), and 11.9% (unaffected controls). Compared to unaffected controls, the risk of injury was 2.15 (95% confidence interval (CI): 1.00-4.60), 2.74 (95% CI: 1.63-4.59), 2.06 (95% CI: 1.24-3.42), and 1.26 (95% CI: 1.00-1.58) in children with autism, ADD/ADHD, psychopathology, and other medical conditions, respectively, after adjusting for child sex, child age, number of children in the household, child race, and family poverty level. Children with autism, ADD/ADHD, and other psychopathology were about 2-3 times more likely to experience an injury that needs medical attention than unaffected controls. Future studies need to clarify the extent to which injuries in young children with autism, ADD/ADHD, and psychopathology are related to core symptoms, comorbid conditions, associated behaviors, or unintentional injuries due to lack of additional supervision from caregivers. (Contains 3 tables.)

Passive seismic datasets are a key technology for exploration and monitoring of subsurface reservoirs. Searching for alternative resources in the framework of the energy transition creates a surge for identifying as many potential sites as possible suitable for geothermal exploitation. The Lower Rhine Embayment, at the western border of North Rhine-Westphalia in Germany, is an extensional system with a very high potential for geothermal exploitation. The area experiences moderate but continuous natural seismicity. Here, we report on a passive seismic dataset recorded with 48 seismic stations centred at and around Eschweiler-Weisweiler. Background seismic noise levels are high at this site due to high levels of anthropogenic noise and thick unconsolidated sedimentary layers. The final station layout is a compromise between targeted network design and suitably quiet locations. We show that the network design allows the application of state-of-the-art methods including waveform-based source location methods and ambient noise velocity imaging methods. [ABSTRACT FROM AUTHOR]