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This article proposes and studies a new type of constant elasticity of volatility (CEV) model, titled LVO-CEV, where the name indicates that the excess return is linear in the volatility. The model has either strong or weak solutions, depending on the elasticity parameter, thanks to a connection to radial Ornstein-Uhlenbeck processes. Attainability of lower bounds and the existence of pricing measures are provided. The model allows for closed-form solutions in the context of expected utility theory for investors with hyperbolic absolute risk aversion (HARA) utilities on terminal wealth and consumption. We estimate and implement our model as well as other popular models of indexes and stocks, providing a fair comparison in portfolio management. [ABSTRACT FROM AUTHOR]

Economic modeling of behavior under uncertainty has almost exclusively used one of two approaches. First comes the mean–variance tradeoff, central to the financial economics literature. The alternative approach uses a specific function to assess expected utility. In this approach, almost all of the economics literature has used either the exponential utility (EU) function, with constant absolute risk aversion (CARA) or the power utility (PU) function with constant relative risk aversion (CRRA). Using a Taylor Series expansion, I show that higher-order terms (skewness and kurtosis) can significantly affect estimates of expected utility. I provide specific formulaic guidance allowing economists to assess when these terms become important. This guidance uses readily observable parameters such as mean, median and variance in a wide array of non-Gaussian statistical distributions. I next review two generalizations, one for CRRA utility, hyperbolic absolute risk aversion (HARA), and one for CARA utility, exponential power (EP). I then introduce the possibility of risk-seeking behavior, both in standard economic theory and in the "value" portion of prospect theory (PT), and provide a new Generalized Logistic Utility (GLU) that automatically incorporates such behavior in its functional form. Next, I introduce issues involved in modeling utility that includes a non-marketable component such as health, the environment, or altruism, and discuss how the choice of utility function alters these models. I then assess the choice between exact utility functions and Taylor Series approximations. I conclude by discussing methods to estimate utility function parameters and methods to choose among alternative estimates. [ABSTRACT FROM AUTHOR]

In the last ten years, the development of automated agricultural machinery has seen noteworthy advancements. Nevertheless, the successful commercialization of these technologies depends critically on their ability to operate safely. This study evaluated the advantages and limitations of current risk assessment and hazard analysis methods currently used to ensure the safety of autonomous agricultural machines. An online survey containing 18 questions was distributed to 711 participants identified as potential individuals who are currently working or have worked on autonomous agricultural machines to determine the type and frequency of risk assessment and hazard analysis methods applied on autonomous agricultural machines, examine the advantages and limitations of each method, and investigate the perceived effectiveness of each method. Frequency analysis was used to determine the most and least utilized risk assessment and hazard analysis methods. The advantages and limitations of each risk assessment and hazard analysis approach were compared. Descriptive statistics (counts, means, medians, percent) and frequency analysis of the variables were used. The three main types of risk assessment and hazard analysis techniques applied to autonomous agricultural machines. The methods are (a) Informal Group Analysis (e.g., Brainstorming), (b) Hazard Analysis and Risk Assessment (HARA), and (c) Failure Mode and Effects Analysis (FMEA). Replicability is perceived as the main advantage of FMEA and HARA, while cost-effectiveness is the main advantage of Informal Group Analysis. The need to have pre-existing data of the autonomous agricultural machine at hand to be able to perform risk assessment and subjectivity are the main limitations of FMEA, HARA, and Informal Group Analysis dealing with novel and revolutionary autonomous agricultural machines. Industry experts do not believe that the risk assessment and hazard analysis procedures now used are reliable and efficient enough to guarantee the safety of autonomous agricultural tractors. This study reveals important information about the current state of risk assessment and hazard analysis methods in the context of autonomous agricultural machinery. This knowledge can inform future research, policy development, and industry practices to ensure the safety of autonomous agricultural machines. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agroindustrial Technology / Jurnal Teknologi Industri Pertanian is the property of IPB University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study investigates ambiguity aversion within the framework of a utility-maximizing investor under a modified constant-elasticity-of-volatility (M-CEV) model for the underlying asset. We derive closed-form solutions of a non-affine type for the optimal allocation and value function via a Cauchy problem. This work generalizes previous results in non-ambiguous settings by extending existing work to Hyperbolic Absolute Risk Aversion utility (HARA), correcting some typos in the literature for Constant Relative Risk Aversion utility (CRRA). Helpful details and derivations are also included in the manuscript. [ABSTRACT FROM AUTHOR]

Human activities have caused significant changes in the structure and function of natural ecosystems and increased ecological risk. In the present study, the trend of land use changes from 1989 to 2021 was evaluated, and then the ecological risk was estimated using the risk index. To monitor the landscape pattern changes, the indicators of Fragmentation (Fi), Separation (Si), Disturbance (Di), Fractal Dimension (FDi), and Vulnerability (Vi) were also investigated. The results revealed that the tidal zones have the highest increasing trend and the water areas have the highest decreasing trend. Also, the results of ecological risk indicate that due to population growth, economic development, and human activities, especially tourism, amount of ecological risk has increased in very high classes with 0.18% and high with 0.23%, respectively. The evaluation of Fi, Si, Di, FDi, and Vi indices also showed that the most changes were related to mangrove forests and the distance between small forest patches increased. According to the results, human activities development and the lack of proper planning have been the main factors of increasing land use changes and ecological risk in the area. Accordingly, continuous monitoring of human activities is necessary to prevent the increase of ecological risk and the reduction of habitat quality in the Hara protected area. [ABSTRACT FROM AUTHOR]

Copyright of Automotive Digest is the property of Automotive Digest Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dejene Bayu,1 Abiyu Mekonnen,2 Jemal Mohammed,3 Dagne Bodena1 1Hiwot Fana Specialized University Hospital, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, Menelik-II College of Health and Medical Sciences, Kotobe Metropolitan University, Addis Ababa, Ethiopia; 3Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Dagne BodenaHiwot Fana Specialized University Hospital, College of Health and Medical Sciences, Haramaya University, PO Box 235, Harar, EthiopiaTel +251 910127241Email dagne2004bodena@gmail.comPurpose: Streptococcus pneumoniae is the major cause of pneumoniae infection among under-five children that leads to high morbidity and mortality. Thus, the aim of this study was to determine the magnitude of Streptococcus pneumoniae in under-five children of an acute respiratory infection, assess its antimicrobial susceptibility patterns, and define the associated factors.Methods: An institutional-based cross-sectional study was conducted on a total of 384 under-five children of acute respiratory infection attending outpatient department of Hiwot Fana Specialized University Hospital, Harar, Ethiopia, from March 1 to 30, 2020. Socio-demographic and clinical data were collected from the study participants using a structured questionnaire. Sputum samples were collected and processed to identify Streptococcus pneumoniae pathogen using the culture and biochemical tests as per the standard procedures. The Kirby–Bauer disk diffusion method was used for antimicrobial susceptibility testing. Data were entered into Epi-data version 3.1 and analyzed by using Statistical Product and Service Solutions version 22.Results: The proportion of Streptococcus pneumoniae in under-five children with acute respiratory infection was 11.2%. About 50% of isolated Streptococcus pneumoniae was resistant to tetracycline and cotrimoxazole, whereas more than 90% of it was susceptible to Ceftriaxone and amoxicillin-clavulanate. Children who lived in rural areas were 3.6 times more likely to have S. pneumoniae compared to children who lived in urban areas (AOR: 3.6, 95% CI: 1.2– 11) and children with familysmokers in a house were 3 times at risk to be infected with S. pneumoniae (AOR: 3, 95% CI: 1.8– 8.0).Conclusion: High antimicrobial resistance of S. pneumoniae against tetracycline and cotrimoxazole was observed and children who lived in rural areas and live with a family of cigarette smoker are factors associated with Streptococcus pneumoniae. Therefore, providing health educations to the family of children rural residents and isolating smokers from the house where children lived are recommended actions to reduce bacteria caused by Streptococcus pneumoniae.Keywords: antibiotic susceptibility, children under-five, S. pneumoniae, Hiwot Fana Specialized University Hospital, Harar, Ethiopia

The major production of paddy fields is grain, which produces rice as the principal ingredient of Indonesian people’s food. The characteristics of the land that can be evaluated or not suitable and the limiting factors influence the suitability of land for lowland rice. East Kutai Regency in East Kalimantan Province has a fairly large paddy field as a grain producer in Bumi Rapak Village and Selangkau Village. The research objectives to understand and explore the suitability class of paddy fields in Bumi Rapak Village, Selangkau Village, and the principal limiting factors. The method applied by matching the growing requirements of lowland rice with the characteristics of paddy fields. We prove that the low availability of P2O5 nutrients so that the actual land suitability class for lowland rice is marginally suitable (S3) and sub-class S3n; the productivity is only 4.54 tons (ha-1 ). Improvement efforts carried out by low-to-moderate inputs with the application of SP-36 fertilizer at a dose of 100 kg (ha-1 ) per growing season, the suitability class increases of quite appropriate (S2) and the S2n sub-class expected to increase productivity to 5.00-6.00 tons (ha-1 ). [ABSTRACT FROM AUTHOR]

Abstrak Kehadiran tumbuhan bawah pada hutan tanaman jati dapat memberikan dampak positif yaitu, menjadi sumber keragaman hayati, menciptakan iklim mikro di lantai hutan, menjaga tanah dari bahaya erosi, serta dapat memelihara kesuburan tanah. Namun keberadaannya seringkali dianggap sebagai kompetitor bagi tanaman yang dibudidayakan. Hutan Pangkuan Desa (HPD) Pitu telah dikelola secara intensif oleh masyarakat yang dilakukan baik di bawah maupun di luar tegakan sehingga diduga mempengaruhi kondisi ekosistem di kawasan tersebut baik terhadap kelimpahan tumbuhan bawah maupun kualitas kimia tanahnya. Tujuan penelitian ini adalah untuk mengetahui keanekaragaman jenis tumbuhan bawah dan kualitas kimia tanah pada berbagai tipe penutupan lahan di HPD Pitu, BKPH Getas. Pengamatan dilakukan dengan menempatkan petak kuadrat berukuran 1 m x 1 m sebanyak 5 petak pada setiap unit lahan secara random. Hasil penelitian menunjukkan pada 4 (empat) penutupan lahan yaitu hutan, semak, ladang, dan pemukiman didominasi oleh jenis yang berbeda tetapi komposisi komunitas pada hutan dan semak memiliki similaritas yang relatif tinggi. Kualitas kimia tanah pada berbagai penutupan lahan tidak berbeda secara signifikan. Aktivitas masyarakat yang tinggi pada berbagai penutupan lahan diduga menjadi penyebab rendahnya hara pada berbagai tipe penutupan. Kondisi keharaan yang miskin hara khususnya pada kawasan hutan tentu akan memengaruhi produktivitas tegakan jati yang merupakan tanaman pokok di kawasan tersebut. Abstract The presence of undergrowth on teak plantations can have a positive impact i.e, a source of biodiversity, creating a microclimate on the forest floor, keeping the soil from the erosion, and can maintain soil fertility. On the other hand, its existence is often regarded as a competitor for cultivated plants. Hutan Pangkuan Desa (HPD) Pitu has been intensively managed by communities undertaken either below or outside the stand so that it is suspected to affect the ecosystem condition in the region both to the abundance of plants and quality of soil chemistry. The purpose of this study was to determine the diversity of undergrowth species and soil chemical qualities in various types of land cover in HPD Pitu, BKPH Getas. The observation was done by placing a 1 m x 1 m square plot of 5 plots on each unit of land. The results showed that 4 (four) land closures i.e forests, shrubs, dry farmland, and settlements were dominated by different species but the community composition in forests and shrubs had a relatively high similarity. The soil chemical quality at various land coverings did not differ significantly. High community activity in various land closures is thought to be the cause of low nutrients in various types of closure. The nutrient-poor condition of the forest, especially in the forest area, will affect the productivity of teak stands, which are the staple crops in the area.

Copyright of Journal of Fisheries Science & Technology is the property of Tarbiat Modares University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper highlights the importance of conducting detailed territorial analyses using all available sources (both archaeological and written) in efforts to comprehend the changes occurring in a given place. The examples used in the paper come from a specific area: La Zubia, part of the Vega de Granada, a wide expanse of fertile plains in the province of Granada. The area of La Zubia is characterized by its large aristocratic properties, known as munyas, and to a lesser extent smaller properties and buildings (such as cottages), which are called huertas. Survey and demarcation records from the 16th century and the Muslim "Books of Habices" provide most of the information about the residential structures and their names: neighborhood (hāra), houses or mansions (dār) and even parks (ŷanna). The paper warns against the risk of drawing hasty conclusions from rough documentation analysis and limited data. Finally, some suggestions regarding future research are made. [ABSTRACT FROM AUTHOR]

Tujuan penelitian ini adalah untuk mengetahui kualitas pupuk organik dari limbah padat industri pulp, dalam rangka meningkatkan nilai tambah limbah. Penelitian pembuatan pupuk organik dilakukan selama dua bulan. Untuk mempercepat proses pengomposan digunakan aktivator hayati dengan dosis 10%. Hasil penelitian menunjukkan bahwa kualitas pupuk organik limbah padat industri pulp masih rendah terutama unsur hara makro seperti P 0,47 - 0,65%; Ca 0,34 - 0,45%; K 0,09 - 0,22%; Mg 0,07 - 0,31 % dan 0,38 - 0,85%. Untuk meningkatkan kualitas pupuk organik tersebut telah dilakukan pencampuran dengan bahan organik seperti pupuk kandang merk KARYANA, pupuk organik merk SUKOIJO, pupuk semi organik ZEOSUPER dan pupuk semi organik ZEOREA. Dari hasil pencampuran dapat diketahui bahwa terjadi peningkatan unsur hara NPK. Perbandingan 10 bagian pupuk organik sludge: 1 bagian ZEOREA, dapat meningkatkan kadar N, P dan K menjadi 4,72%; 2,90% dan 4,09%.

Nowadays systems are becoming more and more connected. Consequently, the co-engineering of (cyber)security and safety life cycles becomes paramount. Currently, no standard provides a structured co-engineering process to facilitate the communication between safety and security engineers. In this paper, we propose a process for coengineering safety and security by the explicit systematization and management of commonalities and variabilities, implicitly stated in the requirements of the different standards. Our process treats the safety and security life cycles as members of a security-informed safety-oriented process line and so it forces safety and security engineers to come together and brainstorm on what might be considered a commonality and what might be considered a variability. We illustrate the usage of our process by systematizing commonalities and variabilities at risk analysis phase in the context of ISO 26262 and SAE J3061. We then draw lessons learnt. Finally, we sketch some directions for future work. [ABSTRACT FROM AUTHOR]

History of Gandhāra is a well known subject. But considerable gaps, which could be filled in by correctly interpreting place-names, still exist. Here, for the first time, an attempt is made to interpret placenames, which throw light on various missing chapters of the history of Gandhāra. Similarly the name, Gandhāra, and its etymology is explained in the light of geographical environment in which it was located. It has also been suggested that Buddhism spread at the grass roots levels by the keen interest of some of the local chiefs who used their utmost financial resources to raise stupas and monasteries now witnessed in the galaxy of ruined structures found throughout the length and breadth of Gandhāra. [ABSTRACT FROM AUTHOR]

Hazard Analysis and Risk Assessment (HARA) in various domains like automotive, aviation, and process industry suffers from the issues of validity and reliability. While there has been an increasing appreciation of this subject, there have been limited approaches to overcome these issues. In the automotive domain, HARA is influenced by the ISO 26262 international standard which details functional safety of road vehicles. While ISO 26262 was a major step towards analysing hazards and risks, like other domains, it is also plagued by the issues of reliability. In this paper, the authors discuss the automotive HARA process. While exposing the reliability challenges of the HARA process detailed by the standard, the authors present an approach to overcome the reliability issues. The approach is obtained by creating a rule-set for automotive HARA to determine the Automotive Safety Integrity Level (ASIL) by parametrizing the individual components of an automotive HARA, i.e., severity, exposure and controllability. The initial rule-set was put to test by conducting a workshop involving international functional safety experts as participants in an experiment where rules were provided for severity and controllability ratings. Based on the qualitative results of the experiments, the rule-set was re-calibrated. The proposed HARA approach by the creation of a rule-set demonstrated reduction in variation. However, the caveat lies in the fact that the rule-set needs to be exhaustive or sufficiently explained in order to avoid any degree of subjective interpretation which is a source of variation and unreliability. [ABSTRACT FROM AUTHOR]

Candidiasis is one of the most important and prevalent opportunistic fungal diseases in human. The leaves of Avicennia marina (Hara) have traditionally widely used in southern regions of Iran to treat different kinds of infections. The purpose of present research is to study the inhibitory effect of aqueous extract of Avicennia marina on candida albicans in laboratory conditions. The leaf of Avicennia marina was collected from coastal areas of south of Iran and dried in the shade after washing and extracted its aqueous extract. The effect of extract was studied by disk diffusion and diffusion in agar methods with embedded sink in different concentrations. The value of MIC and MFC was determined by Macro broth dilution method. The results were analyzed using the SPSS version 21 software. In disk diffusion method in the concentrations of 200 and 1600 µg/disk, the diameter of inhibition zone was 0 and 2.3 mm respectively, and in the concentrations of 10 and 80 mg/ml the diameter of inhibition zone was 0 and 2.7 mmin embedded sink method. It was not possible to determine the values of MIC and MFC due to very limited inhibitory effect of aqueous extract of Avicennia marina on clinical and standard species of candida albicans. According to the obtained results from present research, it can be noted that aqueous extract of the plant has less active ingredients with antifungal effects. It is suggested that phenolic and alcoholic extracts of Avicennia marina should be considered in future research. [ABSTRACT FROM AUTHOR]

We consider the financial planning problem of a retiree wishing to enter a retirement village at a future uncertain date. The date of entry is determined by the retiree's utility and bequest maximisation problem within the context of uncertain future health states. In addition, the retiree must choose optimal consumption, investment, bequest and purchase of insurance products prior to their full annuitisation on entry to the retirement village. A hyperbolic absolute risk-aversion (HARA) utility function is used to allow necessary consumption for basic living and medical costs. The retirement village will typically require an initial deposit upon entry. This threshold wealth requirement leads to exercising the replication of an American put option at the uncertain stopping time. From our numerical results, active insurance and annuity markets are shown to be a critical aspect in retirement planning. [ABSTRACT FROM AUTHOR]

In Japan, the first half of the twentieth century saw a remarkable revival of concern with the cultivation of the belly, with a variety of belly-cultivation techniques, particularly breathing exercise and meditative sitting, widely practiced for improving health and treating diseases. This article carefully examines some practitioners' experiences of belly-cultivation practice in attempting to understand its healing effects for them within their life histories and contemporary intellectual, social and cultural contexts. It shows that belly-cultivation practice served as a medium for some practitioners to reflect on and retell their life stories, and that the personal charisma of certain masters and the communities developing around them provided practitioners with a valuable sense of belonging in an increasingly industrialized and urbanized society. Moreover, these belly-cultivation techniques provided an embodied way for some to explore and affirm their sense of self and develop individual identity. While they were increasingly promoted as cultural traditions capable of cultivating national character, they also served as healing practices by inspiring practitioners with a sense of collective identity and purpose. With these analyses, this article sheds light on the complicated meanings of belly-cultivation for practitioners, and provides illustrative examples of the multitude of meanings of the body, bodily cultivation and healing. [ABSTRACT FROM AUTHOR]

Safety and security are both qualities that concern the overall system. However, these disciplines are traditionally treated independently in the automotive domain. Replacement of classical mechanical systems with safety-critical embedded systems raised the awareness of the safety attribute and caused the introduction of the ISO 26262 standard. In contrast to this, security topics are traditionally seen as attacks of a mechanical nature and as only affecting single vehicles (e.g. door lock and immobilizer related). Due to the increasing interlacing of automotive systems with networks (such as Car2X), new features like autonomous driving, and online software updates, it is no longer acceptable to assume that car fleets are immune to security risks and automated remote attacks. Consequently, future automotive systems development requires appropriate systematic approaches to support cyber security and safety aware development. Therefore, this paper examines threat and risk assessment techniques that are available for the automotive domain and presents an approach to classify cyber-security threats, which can be used to determine the appropriate number of countermeasures that need to be considered. Furthermore, we present a combined approach for safety and security analysis to be applied in early development phases, which is a pre-requisite for consistent engineering throughout the development lifecycle. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Social Research is the property of Journal of International Social Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper develops a new class of aggregation operator based on utility function, which introduces the risk attitude of decision makers (DMs) in the aggregation process. First, under the general framework of utility function, we provide a new operator called the generalized ordered weighted utility proportional averaging (GOWUPA) operator and study its properties which are suitable for any utility function. Then, under the hyperbolic absolute risk aversion (HARA) utility function, we propose another new operator named as the generalized ordered weighted utility proportional averaging-hyperbolic absolute risk aversion (GOWUPA-HARA) operator, and further investigate its families including a wide range of aggregation operators. To determine the GOWUPA-HARA operator weights, we put forward an orness measure of the GOWUPA-HARA operator and analyze its properties. Considering that different DMs may have different opinions towards decision-making and their opinions can be characterized by different orness measures, we construct a new nonlinear optimization model to determine the optimal weights which can aggregate all the individual sets of weights into an overall set of weights. Furthermore, based on the GOWUPA-HARA operator, a method for multiple attribute group decision- making (MAGDM) is developed. Finally, an example is given to illustrate the application of the GOWUPA-HARA operator to the MAGDM. [ABSTRACT FROM AUTHOR]

This article sets out to describe the beneficial effects of breathing methods derived from the Japanese martial arts Aikido and Kashima Shinryu Kenjutsu, as applied to professional dance practice and dance education. I wish to illustrate how change in subjective awareness may be brought about through the fundamental human activity of breathing and how this may affirm and validate a sense of self. The article includes extracts from the thoughts of Japanese Budo master, Minoru Inaba, and observations of undergraduate dance students with whom I continue to explore experiential processes. [ABSTRACT FROM AUTHOR]

False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin®) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin®, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2–4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG. [ABSTRACT FROM AUTHOR]

MCL1 is an anti-apoptotic BCL2 family member that is often overexpressed in various malignant tumors. However, few reports have described the role of MCL1 in squamous cell carcinoma (SqCC) derived from airways including the lung. In this study, we examined whether MCL1 could be a novel druggable target for airway-derived SqCC, for which effective molecular targeted drugs are unavailable. We searched the Kaplan–Meier Plotter database and found that high MCL1 mRNA expression was significantly associated with shorter survival in patients with lower airway (lung) or upper airway (head and neck) derived SqCC. We also explored the Expression Atlas database and learned that authentic lung SqCC cell lines expressing both TP63 and KRT5 mRNA were extremely sparse among the publicly available "lung SqCC cell lines", with an exception being HARA cells. HARA cells were highly dependent on MCL1 for survival, and MCL1-depleted cells were not able to grow, and even declined in number, upon docetaxel (DTX) exposure in vitro and in vivo. Similar in vitro experimental findings, including those in a 3D culture model, were also obtained using Detroit 562 pharyngeal SqCC cells. These findings suggested that combined treatment with MCL1 silencing plus DTX appears highly effective against airway-derived SqCC. • Authentic squamous cell carcinoma (SqCC) cell lines of the lung are sparse. • HARA lung SqCC cells depend highly on MCL1 for survival in vitro and in vivo. • MCL1-silenced HARA cells decline in number upon docetaxel (DTX) exposure. • High MCL1 mRNA expression is linked with shorter survival in lung SqCC patients. • MCL1 depletion + DTX is highly effective against Detroit 562 pharyngeal SqCC cells. [ABSTRACT FROM AUTHOR]