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257 results on '"HAIGHT, A. R."'

3. Changes in early high-risk opioid prescribing practices after policy interventions in Washington State

Author

Sears, Jeanne M., Haight, John R., Fulton-Kehoe, Deborah, Wickizer, Thomas M., Mai, Jaymie, and Franklin, Gary M.

Subjects
Opioids -- Dosage and administration -- Laws, regulations and rules, Prescription writing -- Forecasts and trends, Pharmaceutical policy -- Evaluation, Government regulation, Market trend/market analysis, Business, Health care industry
Abstract

Objective: To test associations between several opioid prescribing policy interventions and changes in early (acute/subacute) high-risk opioid prescribing practices. Data Sources: Population-based workers' compensation pharmacy billing and claims data, Washington State Department of Labor and Industries (January 2008-June 2015). Study Design: We used interrupted time series analysis to test associations between three policy intervention timepoints and monthly proportions of population-based measures of high-risk, low-risk, and any workers' compensation-related opioid prescribing. We also tested associations between the policy intervention timepoints and five high-risk opioid prescribing indicators among workers prescribed any opioids within 3 months after injury: (a) >7 cumulative (not necessarily consecutive) days' supply of opioids during the acute phase, (b) high-dose opioids, (c) concurrent sedatives, (d) chronic opioids, and (e) a composite high-risk opioid prescribing indicator. Principal Findings: Within 3 months after injury, 9 percent of workers were exposed to high-risk and 12 percent to low-risk workers' compensation-related opioid prescribing; 79 percent filled no workers' compensation-related opioid prescription. Among workers prescribed any early (acute/subacute) opioids, the indicator for >7 days' supply of opioids during the acute phase was present for 30 percent, high-dose opioids for 18 percent, concurrent sedatives for 3 percent, and chronic opioids for 2 percent. Beyond a general shift toward more infrequent and lower-risk workers' compensation-related opioid prescribing, each policy intervention timepoint was significantly associated with reductions in specific acute/subacute high-risk opioid prescribing indicators; each of the four specific high-risk opioid prescribing indicators had significant reductions associated with at least one policy. Conclusions: Several state-level opioid prescribing policies were significantly associated with safer workers' compensation-related opioid prescribing practices during the first 3 months after injury (acute/subacute phase), which should in turn reduce transition to chronic opioids and associated negative health outcomes. KEYWORDS analgesics, drug prescriptions, inappropriate prescribing, interrupted time series analysis, opioid, policy, workers' compensation, 1 | INTRODUCTION Over the past two decades, high-risk opioid prescribing practices have contributed to a national epidemic of opioid overdose deaths. (1-4) High-risk opioid prescribing practices include excessive initial [...]

Published
2021
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13. Synthesis of erythromycin derivatives via the olefin cross-metathesis reaction

Author

Hsu, Margaret C., Junia, Adam J., Haight, Anthony R., Weijiang Zhang, and Whittingham, William G.

Subjects
Erythromycin -- Research, Erythromycin -- Atomic properties, Erythromycin -- Chemical properties, Chemistry, Organic -- Research, Biological sciences, Chemistry
Abstract

The synthesis of 6-O-substituted erythromycin derivatives was done applying the olefin cross metathesis. Transition metal alkylidene complexes were used to catalyze the reactions, and the approach enabled the elaboration of the 6-O-allyl group of highly functionalized macrolides at different stages of the synthetic sequence.

Published
2004

15. Estimates of lobster-handling mortality associated with the Northwestern Hawaiian Islands lobster-trap fishery

Author

DiNardo, Gerard T., DeMartini, Edward E., and Haight, Wayne R.

Subjects
Lobsters -- Environmental aspects, Lobster fisheries -- Management -- Environmental aspects, Zoology and wildlife conservation, Company business management, Management, Environmental aspects
Abstract

The commercial lobster fishery in the Northwestern Hawaiian Islands (NWHI) is a distant-water trap fishery that targets the Hawaiian spiny lobster (Panulirus marginatus) and slipper lobster (Scyllarides squammosus). The NWHI [...]

Published
2002

16. Pd-Catalyzed Cross-Coupling Reactions Promoted by Biaryl Phosphorinane Ligands

Author

Laffoon, Joshua D., primary, Chan, Vincent S., additional, Fickes, Michael G., additional, Kotecki, Brian, additional, Ickes, Andrew R., additional, Henle, Jeremy, additional, Napolitano, José G., additional, Franczyk, Thaddeus S., additional, Dunn, Travis B., additional, Barnes, David M., additional, Haight, Anthony R., additional, Henry, Rodger F., additional, and Shekhar, Shashank, additional

Published
2019
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19. Characterization and synthesis of a 6-substituted benzo(b)thiophene

Author

Haight, Anthony R., Wayne, Gregory S., Lannoye, Gregory S., Parekh, Shyamal I., Zhang, Weijiang, Copp, Richard R., and Hollis, L. Steven

Subjects
Substitution reactions -- Research, Leukotrienes -- Synthesis, Enzymes -- Synthesis, Biological sciences, Chemistry
Abstract

Research was conducted to characterize and synthesize an unknown impurity seen in the synthesis of zileuton. The impurity was discovered to be a 6-substituted benzo(b)thiophen that has went through the process of electrophilic substitution in the 6 position. Its structural assignment was confirmed through a nine-step process involving a regioselective Friedel-Crafts coupling between 1-(benzo(b)thien-2-yl)ethanol and 2-hydroxythioanisole and the formation of a benzo(b)thiophene from an o-methylthiobenzaldehyde and chloroacetone.

Published
1998

21. Biology and management of deepwater snappers of Hawaiian Archipelago

Author

Haight, Wayne R., Kobayashi, Donald R., and Kawamoto, Kurt E.

Subjects
Hawaii -- Natural resources, Fishes, Lutjanidae -- Management, Fishing -- Management, Marine fishes, Agricultural industry, Business, Company business management, Management, Natural resources
Abstract

Commercial and recreational deepwater (100-400 m) bottomfishing in Hawaii targets a multispecies group of lutjanid snappers. Relatively little is known about the life history of these species. Research in Hawaii and elsewhere in the tropical Pacific suggests that most of the species are slow growing, long lived, and have a relatively high age at sexual maturity. Stock assessment is difficult because of the multispecies nature of the fishery. However, recent analysis of commercial fishery data indicates that some of the species may currently be overexploited Research is underway to determine the efficacy of management measures such as minimum-size limit changes or seasonal and spatial fishery closures to maintain optimal spawning biomass., Introduction Commercial exploitation of deepwater snappers in Hawaii began before the turn of the century (Cobb, 1903), and except for a hiatus during World War II, has continued to the [...]

Published
1993

22. Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Author

Haight, Barbara R, primary, Learned, Susan M, additional, Laffont, Celine M, additional, Fudala, Paul J, additional, Zhao, Yue, additional, Garofalo, Amanda S, additional, Greenwald, Mark K, additional, Nadipelli, Vijay R, additional, Ling, Walter, additional, Heidbreder, Christian, additional, Andersen, James L., additional, Bailey, Genie L., additional, Bartley, Scott Robert, additional, Biunno, Michael J., additional, Boyett, Brent, additional, Carr, Jesse M., additional, Cifuentes, Eduardo, additional, Duarte-Sckell, Sandra Daniela, additional, Dueno, Otto R., additional, Harrison, Boyde J., additional, Hassman, David R., additional, Hoffman, Kent Steven, additional, Isacesu, Valentin, additional, Ishaque, Saleem, additional, Kakar, Rishi, additional, Kampman, Kyle, additional, Knapp, Richard D., additional, Konis, George, additional, Kunovac, Jelena, additional, Kwentus, Joseph A., additional, Levinson, Lawrence S., additional, Malhotra, Shishuka, additional, Mehra, Vishaal, additional, Mofsen, Ricky Stuart, additional, Peyton, Marvin Lane, additional, Pujari, Gita G., additional, Ranjan, Rakesh, additional, Rutrick, Daniel, additional, Seal, Gregory, additional, Segal, Scott Daniel, additional, Shiwach, Rajinder, additional, Thomas, Haydn Mikel, additional, Ventre, Peter Paul, additional, Vijapura, Amit K., additional, Walling, David P., additional, and Wiest, Katharina L., additional

Published
2019
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23. Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor

Author

Barnes, David M., primary, Shekhar, Shashank, additional, Dunn, Travis B., additional, Barkalow, Jufang H., additional, Chan, Vincent S., additional, Franczyk, Thaddeus S., additional, Haight, Anthony R., additional, Hengeveld, John E., additional, Kolaczkowski, Lawrence, additional, Kotecki, Brian J., additional, Liang, Guangxin, additional, Marek, James C., additional, McLaughlin, Maureen A., additional, Montavon, Donna K., additional, and Napier, James J., additional

Published
2019
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24. The Critical Researcher's Dilemma.

Author

Haight, Timothy R.

Abstract

"The critical researcher's dilemma is that, while the topics, theories, and methods we have studied now seem to be in favor, the moral views and general analysis that prompted our studies are not." (Author)

Published
1983

25. The Mass Media: Aspen Institute Guide to Communication Industry Trends.

Author

Sterling, Christopher H., Haight, Timothy R., Sterling, Christopher H., and Haight, Timothy R.

Abstract

Intended to provide a single reference source for the most significant statistics describing communication industry trends in the United States since 1900, this book is a collection and assessment of the currently available quantitative descriptive information on mass media industries. The core of the book is its more than 300 tables of data on the publishing, motion picture, recording, and broadcast industries. These data are supplemented by a brief interpretative text, an analysis of source reliability and validity, and a listing of several sources of further information in each subject area. Sections focus on the following topics in the media industries: growth, ownership and control, economics, employment and training, content trends, audience size and characteristics, and United States media industries abroad. (DF)

Published
1978

27. How Community Groups Use Computers.

Author

Haight, Timothy R. and Rubinyi, Robert M.

Abstract

Surveyed 15 community organizations and 13 organizations that provide computer services to community groups to determine types of computer systems used, costs, and effects. Concluded that the technology can be useful for interest-group activities and that its adoption is related to moderate size, wealth, and access to information. (PD)

Published
1983

28. Efficacy and Safety of a Monthly Buprenorphine Depot Injection for Opioid Use Disorder: A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial

Author

Haight, Barbara R., primary, Learned, Susan M., additional, Laffont, Celine M., additional, Fudala, Paul J., additional, Zhao, Yue, additional, Garofalo, Amanda S., additional, Greenwald, Mark, additional, Nadipelli, Vijay R., additional, Ling, Walter, additional, Heidbreder, Christian, additional, and Investigators, Study, additional

Published
2018
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32. Internal coordination at tin promotes selective alkyl transfer in the Stille coupling reaction

Author

Vedejs, Edwin, Haight, Anthony R., and Moss, William O.

Subjects
Organometallic compounds -- Research, Chemical bonds -- Research, Chemistry
Abstract

Tin halide compounds are derived in 50% yields from the hydrozirconation of triallylamine followed by the addition of the corresponding Sn-halide. These compounds form air-stable alkyl derivatives which easily undergo Stille coupling with aryl and alkenyl halides after treatment with lithiated alkyls. The tin functionality exhibits internal coordination which induces selective alkyl transfer via metal-alkyl exchange at the exocyclic Sn-C bond. Moreover, the results indicate that palldium-catalyzed aryl or alkenyl exchange is faster than alkyl exchange.

Published
1992

33. Allylation of erythromycin derivatives: introduction of allyl substituents into highly hindered alcohols

Author

Stoner, Eric J., Peterson, Matthew J., Allen, Michael S., DeMattei, John A., Haight, Anthony R, Leanna, M. Robert, Patel, Subhash R., Plata, Daniel J., Premchandran, Ramiya H., and Rasmussen, Michael

Subjects
Erythromycin -- Analysis, Biological sciences, Chemistry
Abstract

Under palladium (o) catalysis, functionalized erythromycin 9-oxime derivatives are 6-O-allylated under mild conditions using substituted allyl-tert-butyl carbonates. Allyl tert-butyl carbonates provide higher yields in this reaction than lesser substituted carbonates such as ethyl or isopropyl.

Published
2003

34. General method for the palladium-catalyzed allylation of aliphatic alcohols

Author

Haight, Anthony R., Stoner, Eric J., Peterson, Matthew J., and Grover, Vandana K.

Subjects
Alcohols -- Chemical properties, Alcohols -- Composition, Carbonates -- Chemical properties, Chemistry, Organic -- Research, Organic compounds -- Chemical properties, Organic compounds -- Composition, Palladium catalysts -- Chemical properties, Biological sciences, Chemistry
Abstract

Research has been conducted on aliphatic alcohols. The authors describe palladium catalysis-mediated method developed to investigate aliphatic alcohols' coupling with allyl carbonates, and they report the presence of transient allyl carbonates in the couplings.

Published
2003

40. An efficient stereocontrolled strategy for the synthesis of hydroxyethylene dipeptide isosteres

Author

Stuk, Timothy L., Haight, Anthony R., Scarpetti, David, Allen, Michael S., Menzia, Jerome A., Robbins, Timothy A., Parekh, Shyamal I., Langridge, Denton C., Tien, Jien-Heh, Pariza, Richard J., and Kerdesky, Francis A.J.

Subjects
Peptides -- Synthesis, Phenylalanine -- Analysis, Stereochemistry -- Analysis, Biological sciences, Chemistry
Abstract

An economical five-step method converts L-phenylalanine into a hydroxyethylene dipeptide isostere through the formation and stereospecific reduction of an intermediate enaminone. Incorporation of R1 in the side chain of an amino acid and Grignard reagent-derived-R2 facilitate the preparation of various isosteres.

Published
1994

47. Biology and Management of Deepwater Snappers of the Hawaiian Archipelago

Author

Haight, Wayne R., Kobayashi, Donald R., and Kawamoto, Kurt E.

Subjects
Fisheries, Biology, Management
Abstract

Commercial and recreational deepwater (100-400 m) bottom-fishing in Hawaii targets a multispecies group of lutjanid snappers. Relatively little is known about the life history of these species. Research in Hawaii and elsewhere in the tropical Pacific suggests that most of the species are slow growing, long lived, and have a relatively high age at sexual maturity. Stock assessment is difficult because of the multispecies nature of the fishery. However, recent analysis of commercial fishery data indicates that some of the species may currently be overexploited. Research is underway to determine the efficacy of management measures such as minimum-size limit changes or seasonal and spatial fishery closures to maintain optimal spawning biomass.

Published
1993

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