1. Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART
- Author
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Lehmann, Clara, Däumer, Martin, Boussaad, Ibrahim, Sing, Tobias, Beerenwinkel, Niko, Lengauer, Thomas, Schmeisser, Norbert, Wyen, Christoph, Fätkenheuer, Gerd, and Kaiser, Rolf
- Subjects
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HIV infections , *PROGNOSIS , *GLYCOPROTEINS , *HIGHLY active antiretroviral therapy , *HIV-positive persons - Abstract
Abstract: Background: Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. Objectives: To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time. Methods: Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120. Results: Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching. Conclusions: Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option. [Copyright &y& Elsevier]
- Published
- 2006
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