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4. Inversion of Thin-Bedded Multi-Lithology Settings: What are the Critical Requirements for a Successful Seismic Inversion?

Author

H. Poore, A.F. Jakobsen, H.J. Hansen, A. Alexander, and C. Ellis

Subjects
Azimuth, Data processing, Lithology, Data quality, Seismic inversion, Seismic scale, Inversion (meteorology), Petrology, Oil shale
Abstract

Summary Seismic inversion of thin-bedded multi-lithology stratigraphic systems suffers from problems of nonuniqueness despite significant advances in acquisition and data processing. The Cambo Discovery (West of Shetlands, UKCS) provides a good case study comprising stacked sub-seismic sand reservoirs interbedded with thin coals and shales. Appraisal wells drilled on 1990’s vintage conventional streamer data have proved areas of thicker (but still sub-seismic) sand bodies away from the crestal discovery well. These data were considered too poor quality to confidently define and map sand bodies using quantitative interpretation techniques. The elastic rock physical properties of brine sands and shale overlap at log-scale on rock physics templates and at seismic scale the hydrocarbonbearing sands can also overlap with variable coals. Nevertheless, over the past 5-6 years our confidence in quantitative interpretation techniques has significantly improved. Broadband dual azimuth streamer data acquired in 2011 and 2014 provide high quality data. Developments in seismic inversion techniques, specifically direct probabilistic inversion, have allowed more confident lithology prediction. We share results of both deterministic simultaneous AVO inversions and a recent direct probabilistic inversion to lithology. The results of the latter show a significant improvement in prediction of sand distribution.

Published
2021
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6. Direct Probabilistic Inversion for Facies Using Zoeppritz Reflectivity Model

Author

H.J. Hansen and A.F. Jakobsen

Subjects
Zoeppritz equations, Nonlinear system, Computer science, Bayesian probability, Probabilistic logic, Probability density function, Rule-based system, Inverse problem, Spatial analysis, Algorithm
Abstract

Summary Probabilistic one-step (or direct) inversion methods are now being used frequently in the industry to infuse geophysical and geological spatial information into the inverse problem with the added benefit/complexity of solving for probabilities of the variables of interest. The inherent ambiguity of the inverse problem can be addressed by solving for probability density functions, and the Bayesian method is the natural framework for assimilating data, modelling and prior soft or hard knowledge/information. The approximate local likelihood method is a fast method that can solve direct probabilistic inversion problems taking spatial information accurately into account. The method is very flexible and has few limitations wrt spatial models and RP models which can be analytical or rule based models. However all applications so far has used the linear Aki-Richards reflectivity model which simplifies the problem. In the study we will use an extension of the method to solve the nonlinear Zoeppritz reflectivity model and apply it to a challenging AVO problem of coals where the Zoeppritz equation would be more appropriate since the small contrast assumption of the Aki-Richards equation no longer holds.

Published
2020
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7. Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS

Author

Caroline Lavie, Fabien Rollot, Françoise Durand-Dubief, Romain Marignier, Iuliana Ionescu, Romain Casey, Thibault Moreau, Patricia Tourniaire, Michael Hutchinson, Marie Béatrice D’Hooghe, David-Axel Laplaud, Pierre Clavelou, Jérôme De Sèze, Marc Debouverie, David Brassat, Jean Pelletier, Christine Lebrun-Frenay, Emmanuelle Le Page, Giovanni Castelnovo, Eric Berger, Patrick Hautecoeur, Olivier Heinzlef, Luca Durelli, Marinella Clerico, Maria Trojano, Francesco Patti, Sandra Vukusic, A. Alpérovitch, H. Carton, M.B. d’Hooghe, O. Hommes, M. Hutchinson, P. Adeleine, A. Biron, P. Cortinovis-Tourniaire, J. Grimaud, M. Hours, T. Moreau, S. Vukusic, C. Confavreux, G. Chauplannaz, D. Latombe, M. Clanet, G. Lau, L. Rumbach, J.Y. Goas, F. Rouhart, A. Mazingue, E. Roullet, M. Madigand, P. Hautecoeur, P. Brunet, G. Edan, C. Allaire, G. Riffault, J. Leche, T. Benoit, C. Simonin, F. Ziegler, J.C. Baron, Y. Rivrain, R. Dumas, D. Loche, J.C. Bourrin, B. Huttin, B. Delisse, I. Gibert, C. Boulay, M. Verceletto, G. Durand, G. Bonneviot, R. Gil, M.A. Hedreville, C. Belair, R.J. Poitevin, J.L. Devoize, P. Wyremblewski, F. Delestre, A. Setiey, G. Comi, M. Filippi, A. Ghezzi, V. Martinelli, P. Rossi, M. Zaffaroni, M.R. Tola, M.P. Amato, C. Fioretti, G. Meucci, M. Inglese, G.L. Mancardi, D. Gambi, A. Thomas, M. Cavazzuti, A. Citterio, A. Heltberg, H.J. Hansen, O. Fernandez, F. Romero, T. Arbizu, J.J. Hernandez, C. De Andres de Frutos, D. Geffner Sclarky, Y. Aladro Benito, P. Reyes Yanes, M Aguilar, J.A. Burguera, R. Yaya, W. Bonakim Dib, D. Arzua-Mouronte, C.J.M. Sindic, R. Medaer, H. Roose, K.M.J. Geens, D. Guillaume, M. Van Zandycke, J. Janssens, M. Cornette, L. Mol, F. Weilbach, P. Flachenecker, H.P. Hartung, J. Haas, I. Tendolkar, E. Sindrn, H.W. Kölmel, D. Reichel, M. Rauch, S. Preuss, S. Poser, E. Mauch, S. Strausser-Fuchs, H. Kolleger, S. Hawkins, S.J.L. Howell, J.E. Rees, A. Thompson, M. Johnson, M. Boggild, R.P. Gregory, D. Bates, I. Bone, C. Polman, S. Frequin, P. Jongen, J. Correia de Sa, M.E. Rio, S. Huber, J. Lechner-Scott, L. Kappos, I. Ionescu, C. Cornu, M. El-Etr, E.E. Baulieu, M Schumacher, D.H. Miller, M. Pugeat, C. d’Archangues, J. Conard, J. Ménard, R. Sitruk-Ware, C. Pelissier, S. Dat, J. Belaïsch-Allard, N. Athéa, D. Büschsenschutz, O. Lyon-Caen, R. Gonsette, J.P. Boissel, P. Ffrench, F. Durand-Dubief, F. Cotton, C. Pachai, L. Bracoud, G. Androdias, R. Marignier, D.A. Laplaud, S. Wiertlewski, C. Lanctin-Garcia, G. Couvreur, G. Madinier, P. Clavelou, F. Taithe, D. Aufauvre, N. Guy, A. Ferrier, J. De Sèze, N. Collongues, M. Debouverie, F. Viala, D. Brassat, A. Gerdelat-Mas, P. Henry, J. Pelletier, A. Rico-Lamy, C. Lebrun-Frenay, E. Lepage, V. Deburghraeve, G. Castelnovo, E. Berger, M. Blondiau, O. Heinzlef, M. Coustans, C. Clerc, L. Rieu, M. Lauxerois, G. Hinzelin, J.C. Ouallet, D. Minier, P. Vion, N. Gromaire-Fayolle, N. Derache, E. Thouvenot, M. Sallansonnet-Froment, P. Tourniaire, L. Toureille, F. Borgel, B. Stankoff, C. Moroianu, A.M. Guennoc, C.L. Tournier-Gervason, S. Peysson, M. Trojano, F. Patti, E. D’Amico, L. Motti, L. Durelli, A. Tavella, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Observatoire Français de la Sclérose En Plaques [Lyon] (OFSEP), Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Henri Duffaut (Avignon), National MS Center Melsbroek, Vrije Universiteit Brussel [Bruxelles] (VUB), Vrije Universiteit Brussel (VUB), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Laboratoire de Neuroimagerie in Vivo (LNV), CHU Strasbourg-Centre National de la Recherche Scientifique (CNRS), Les Hôpitaux Universitaires de Strasbourg (HUS), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Neurologie vasculaire, pathologie neuro-dégénérative et explorations fonctionnelles du système nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse], Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Universitaire de Nice (CHU Nice), Université Côte d'Azur (UCA), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de Neurologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL), centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Università degli studi di Torino = University of Turin (UNITO), University of Catania [Italy], Hospices Civils de Lyon, Departement de Neurologie (HCL), Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Protéines membranaires transductrices d'énergie (PMTE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre de Recherches sur les Macromolécules Végétales (CERMAV ), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Environnement Ville Société (EVS), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Solvay (France), Laboratoire des Mécanismes et Transfert en Géologie (LMTG), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institute of Evolutionary Biology, University of Edinburgh, Université de Lille, Sciences et Technologies, Service de Génétique Médicale [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Différenciation, interaction, activation et migration des sous-populations lymphocitaires humaines, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Laboratoire Ecologie Fonctionnelle et Environnement (ECOLAB), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), RMN et optique : De la mesure au biomarqueur, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Department of Neurology, CHU Lyon, Institut de Recherche de Chimie Paris (IRCP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Hôpital de Hautepierre [Strasbourg], Laboratoire de Réactivité des Surfaces et des Interfaces (LRSI), Département de Physico-Chimie (DPC), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Empenn, Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Biologie des Interactions Neurones / Glie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques, European Leukodystrophies Association, PHRC National, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pierre Wertheimer, Département de Neurologie, Laboratoire de Mathématiques (LAMA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Nottingham Scientific Limited, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Turin, Università degli studi di Torino (UNITO), University of Bari Aldo Moro (UNIBA), Department of Neurosciences, Università degli studi di Catania [Catania], Centre de recherche en neurosciences de Lyon (CRNL), Neuroépidémiologie, Institut de Physique du Globe de Paris (IPGP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Recherche pour le Développement (IRD)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale des Travaux Publics de l'État (ENTPE)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lavie, Caroline, Rollot, Fabien, Durand-Dubief, Françoise, Marignier, Romain, Ionescu, Iuliana, Casey, Romain, Moreau, Thibault, Tourniaire, Patricia, Hutchinson, Michael, D’Hooghe, Marie Béatrice, Laplaud, David-Axel, Clavelou, Pierre, De Sèze, Jérôme, Debouverie, Marc, Brassat, David, Pelletier, Jean, Lebrun-Frenay, Christine, Le Page, Emmanuelle, Castelnovo, Giovanni, Berger, Eric, Hautecoeur, Patrick, Heinzlef, Olivier, Durelli, Luca, Clerico, Marinella, Trojano, Maria, Patti, Francesco, Vukusic, Sandra, on behalf of PRIMS and POPARTMUS, Investigator, Filippi, Massimo, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Neuroimagerie: méthodes et applications (Empenn), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur les Macromolécules Végétales (CERMAV), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Laboratoire Motricité, Interactions, Performance, Université de Nantes (UN), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg ), CEA-Direction de l'Energie Nucléaire (CEA-DEN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction de l'Energie Nucléaire (CEA-DEN), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Service de neurologie [Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Jean Minjoz, Service de Neurologie [CHU Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Service de Neurologie [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
relapses, Neurology, [SDV]Life Sciences [q-bio], MESH: Pregnancy Complications / physiopathology, 0302 clinical medicine, MESH: Pregnancy, Anesthesia, Conduction, Recurrence, MESH: Anesthesia, Conduction / adverse effects, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, reproductive and urinary physiology, relapse, Postpartum Period, post-partum, MESH: Follow-Up Studies, MESH: Multiple Sclerosis / physiopathology, Obstetrical Analgesia, MESH: Multiple Sclerosis / chemically induced, Anesthesia, Female, pregnancy, Adult, medicine.medical_specialty, Clinical Neurology, Multiple sclerosis, MESH: Postpartum Period, 03 medical and health sciences, medicine, Humans, Multiple sclerosi, Post partum, Retrospective Studies, Pregnancy, MESH: Humans, MESH: Pregnancy Complications / chemically induced, business.industry, Neurotoxicity, MESH: Adult, MESH: Retrospective Studies, neuraxial analgesia, medicine.disease, MESH: Recurrence, Multiple sclerosis, neuraxial analgesia, post-partum, pregnancy, Pregnancy Complications, Increased risk, Neurology (clinical), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract

Background: Obstetrical analgesia remains a matter of controversy because of the fear of neurotoxicity of local anesthetics on demyelinated fibers or their potential relationship with subsequent relapses. Objective: To assess the impact of neuraxial analgesia on the risk of relapse during the first 3 months post-partum, with a focus on women who experienced relapses during pregnancy. Methods: We analyzed data of women followed-up prospectively during their pregnancies and at least 3 months post-partum, collected in the Pregnancy in Multiple Sclerosis (PRIMS) and Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPARTMUS) studies between 1992–1995 and 2005–2012, respectively. The association of neuraxial analgesia with the occurrence of a post-partum relapse was estimated by logistic regression analysis. Results: A total of 389 women were included, 215 from PRIMS and 174 from POPARTMUS. In total, 156 women (40%) had neuraxial analgesia. Overall, 24% experienced a relapse during pregnancy and 25% in the 3 months post-partum. Women with a pregnancy relapse were more likely to have a post-partum relapse (odds ratio (OR) = 1.83, p = 0.02), independently of the use of neuraxial analgesia. There was no association between neuraxial analgesia and post-partum relapse (OR = 1.08, p = 0.78). Conclusion: Neuraxial analgesia was not associated with an increased risk of post-partum relapses, whatever multiple sclerosis (MS) activity during pregnancy.

Published
2019
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11. Non-Gaussian Linear Inversion of Reflection Seismic Data

Author

P.S. Christiansen, T.M. Hansen, and H.J. Hansen

Subjects
symbols.namesake, Gaussian, Mathematical analysis, symbols, Seismic inversion, Model parameters, Inversion (meteorology), Inverse problem, Geology, Physics::Geophysics
Abstract

The method of seismic inversion aims to estimate subsurface properties from seismic data, thereby providing us with a model of the earth. Often model parameters are assumed to be Gaussian distributed because it makes the inverse problem more tractable as it can be solved analytically by least-squares based algorithms (Buland and Omre, 2003).

Published
2018
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13. [Untitled]

Author

A. Tagne, E. Neergaard, H.J. Hansen, and C. The

Subjects
Chlorosis, biology, Host (biology), fungi, Acremonium strictum, food and beverages, Xylem, Wilting, Plant Science, Horticulture, Vascular bundle, biology.organism_classification, Botany, Phloem, Sieve tube element, Agronomy and Crop Science
Abstract

Different effects of Acremonium strictum from Cameroon on maize cultivars Ndock 8701, CMS 8704 and CMS 8501 were investigated. Observations of symptoms and re-isolation of the pathogen showed that the disease causes chlorosis, leaf necrosis, stem necrosis, barren plants and wilting symptoms. Reduction in growth and yield is demonstrated. In the cultivar Ndock 8701 the pathogen showed systemic development in the host tissues with inter- and intracellular colonization of the vascular bundle and adjacent tissues including the protoxylem lacuna, xylem vessels, metaxylem, sieve tubes, protophloem and metaphloem. Gels and gums were observed in the maize xylem vessels after fungal invasion and are part of the host defence response. Coloration corresponding to acidic carbohydrates and phenolic compounds was recorded. This is the first demonstration of the pathogenic nature of A. strictum in maize from Cameroon as well as the observation of gels and gums. This pathogen must be regarded as important considering its interaction in maize.

Published
2002
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14. Time-lapse Seismic Reservoir Characterization Used for Reservoir Model Update of a Mature Chalk Field - The South Arne Ca

Author

R. Lamb, M.K. Rosengreen, O.V. Vejbaek, H.J. Hansen, V. Volkov, and A.F. Jakobsen

Subjects
Regional geology, Hydrogeology, Engineering geology, Reservoir modeling, Seismic inversion, sense organs, Volcanism, skin and connective tissue diseases, Petrology, Igneous petrology, Geomorphology, Geology, Environmental geology
Abstract

The use of time-lapse seismic data has changed reservoir management of the South Arne field, where an increasing volume of marginal reserves are being targeted. This paper describes the use of the time-lapse seismic data in a physical context, where estimated time-lapse time-shifts are used for reservoir compaction estimation and its impact on the reservoir modelling. The time-lapse amplitude changes are inverted for change in acoustic impedance and vp/vs ratio. A reservoir state dependent rock physics model enables an estimation of saturation changes, which contains detailed information about the water sweep; information which is not present in neither seismic NRMS maps nor in the initial reservoir model.

Published
2014
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15. Rock Physics–driven Seismic Reservoir Characterization of the Siri

Author

H.J. Hansen and K. Westeng

Subjects
Tectonics, Engineering geology, Petrophysics, Reservoir modeling, Volcanism, Economic geology, Petrology, Igneous petrology, Geology, Environmental geology
Abstract

Quantitative interpretation of seismic using rock physics inversion, combined with simultaneous AVO inversion, may significantly improve our understanding of the reservoir between the wells, where we have more direct measurements of petrophysical properties such as saturation, porosity and mineral composition. The workflow is demonstrated on surface seismic data acquired over the Siri field, a Paleocene reservoir located in the Danish North Sea, characterized by glauconite rich, fine-grained, wellsorted sand, embedded in mud- and marl stones. The results can be used for well planning, as well as input to geological model building.

Published
2012
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16. Innovations in time

Author

V. Aarre, H.J. Hansen, M. Tang, J. Marshall, J. Herwanger, S. Pickering, and J. O. Paulsen

Subjects
Geophysics, Regional science, Geology
Published
2007
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17. Pre‐stack seismic inversion of offset stacked data: Diagnostics and remedies for overestimated angles of incidence, a case study

Author

Leon Barens and H.J. Hansen

Subjects
Total internal reflection, Offset (computer science), Inversion (meteorology), Geodesy, Poisson distribution, Reflectivity, Physics::Geophysics, symbols.namesake, Wavelet, symbols, Seismic inversion, Acoustic impedance, Seismology, Geology
Abstract

Summary In seismic inversion, multiple sub-stacked seismic data volumes are used to derive the petro-elastic parameters such as acoustic impedance and Poisson’s Ratio. The relation between the seismic data and these parameters depends on the angle dependent reflectivity. Here, we present a series of diagnostics from which we determine that the angles of incidence used in our case study are overestimated. Without correction this overestimation would lead to sub-optimal inversion results. A systematic approach is used in which the diagnostics are monitored to arrive at optimised angles of incidence. In the case study, we found that a reduction in the angles of incidence of approximately 3 (Near), 5 (Mid) and 9 (Far) improved the wavelets extracted at two well locations and improved the quality of the well synthetics to seismic ties. And for these reduced angles, the accuracy and detail in the petro-elastic properties derived from simultaneous pre-stack seismic inversion improved significantly. We conclude that in the context of simultaneous pre-stack seismic inversion an accurate determination of angles of incidence becomes vital when seismic sub-stack angles of incidence approach critical angle.

Published
2006
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19. Millimetre-wave radars in targeting and data linking operations

Author

H.J. Hansen, A.S. Kulessa, and Graham Brooker

Subjects
Engineering, Radar tracker, Radar engineering details, W band, business.industry, Pulse-Doppler radar, Electronic engineering, Clutter, Radar display, Low-frequency radar, business, Radar configurations and types
Abstract

Millimetre-wave (W-band=75-110 GHz) radars are poised to form an important component of autonomous vehicle operations because high frequency systems are able to provide the conformal miniaturized solutions necessary for many robotic applications. A serial programmable integrated radar threat simulator (SPIRTS) that transmits 95 GHz centred emissions for investigating air-to-surface target threats has been developed and the performance of this unit in a targeting role is projected. Targeting operations at W-band are compared with those at lower K/sub a/ and X band frequencies. The upsides and downsides of W-band operation in clutter generation and in multi-path signal fading, important for future high frequency communication links, are highlighted. Clear air propagation effects for datalinking operations are also discussed for W band emissions.

Published
2004
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22. H-reflex modulation during gait in multiple sclerosis patients with spasticity

Author

Thomas Sinkjær, H.J. Hansen, and Egon Toft

Subjects
Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Modulation index, Electromyography, Stimulus (physiology), H-Reflex, Physical medicine and rehabilitation, Reference Values, Isometric Contraction, medicine, Spastic, Reaction Time, Humans, Spasticity, Muscle, Skeletal, Gait, Soleus muscle, Afferent Pathways, medicine.diagnostic_test, business.industry, Multiple sclerosis, Signal Processing, Computer-Assisted, General Medicine, Anatomy, Middle Aged, medicine.disease, Neurology, Muscle Spasticity, Female, Neurology (clinical), H-reflex, medicine.symptom, Tibial Nerve, business
Abstract

The aim of the present study was to quantitate the Hoffmann (H-) reflex modulation in the soleus muscle of spastic multiple sclerosis patients during walking at different stimulus strengths, and to quantitate the influence of the excitation level of the soleus muscle on the H-reflex. The H-reflex modulation was quantified by the minimum H-reflex in the swing phase and the modulation index introduced by Yang et al. (1). Stimulus strengths were matched between subjects, and only stimuli intensities, which reflect modulation in the H-reflex with true neurophysiological origin, were used. Based on this approach, we found that the reflex modulation is impaired in moderate spastic patients at both a strong and a weak afferent input to the motoneuron pool in consistency with studies on severe spastic patients. This study concludes that the H-reflex modulation in the spastic patients is only related to the excitation level of the muscles, whereas both the excitation level and other factors than the excitation level are known to influence the H-reflex modulation in healthy subjects.

Published
1995
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24. Immu-LL2

Author

R. Stein, L.B. Shih, R.M. Sharkey, H.J. Hansen, and D.M. Goldenberg

Subjects
Pharmacology, Pharmacology (medical)
Published
1993
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26. Whistler Duct Lifetimes

Author

H.J. Hansen, M.W.J. Scourfield, and J.P.S. Rash

Subjects
Atmospheric Science, Geophysics, General Engineering, General Earth and Planetary Sciences, General Environmental Science
Published
1983
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27. Whistler duct dimensions from TV auroral images

Author

M.W.J. Scourfield and H.J. Hansen

Subjects
Physics, Whistler, business.industry, Cyclotron, Electron precipitation, Astronomy and Astrophysics, Electron, Geophysics, Radiation, Electron cyclotron resonance, Physics::Geophysics, law.invention, Optics, Space and Planetary Science, law, Physics::Space Physics, Light emission, Ionosphere, business
Abstract

Whistler mode VLF radiation propagates between opposite hemispheres of the earth in field aligned ducts of enhanced plasma density. Despite the fact that whistler theory is firmly based on the existence of such ducts,there is little knowledge of their cross-sectional size or shape. Mid-latitude (L=4) ground based observations from Sanae, Antarctica, of ionospheric auroral optical emissions (imaged on a low-light level TV system) are observed in association with VLF radio emissions (recorded on a broadband VLF receiver). These optical emissions are Interpreted as arising from electrons which Interact with ducted VLF radiation via the electron cyclotron interaction. These observations provide estimates of 100 km by 400km for whistler duct cross-sections in the equatorial plane.

Published
1989
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28. Contents, Vol. 48, 1987

Author

Christoph J. Lauer, F. Zierau, Michael von Rad, Bruce Christiansen, K.F. Augustiny, C. Lauer, Susan Chauncey, Paul S. Russell, M. Wootton, S.W. Touyz, Bertram Dippel, S. Waadt, S.M. Dunn, H.J. Hansen, Afshin Veiseh, J. Olesen, D. Kühne, George Molnar, Herbert Weiner, Susan E. Abbey, Bruce D. Kirkcaldy, S. Rasmussen, N. Yashiro, P.J.V. Beumont, David M. Garner, Yvette Taché, Mary Gutmann, K.M. Pirke, Katrin Majer-Trendel, Almuth Sellschopp, R.J. Young, M. Kastrup, Y. Sugiyama, Giovanni A. Fava, Doreen Rosenthal, Z.J. Lipowski, Daphne Glaun, J.-C. Krieg, Rob Sanson-Fisher, Jürgen-Christian Krieg, Mathias Berger, C. Bürki, B. Kijne, Hellmuth Freyberger, Dieter Riemann, D. Loldrup Poulsen, Barry Blackwell, R.G. Laessle, Marion P. Olmsted, Rosalyn A. Griffiths, E. Heim, M. Rothenbühler, S. Sato, Wendi Rockert, Jules L. Dienstag, Stephanie von Ammon Cavanaugh, Hoyle Leigh, Hans W. Künsebeck, David B. Herzog, J.M. Steel, L. Valach, S. Okuse, L. Schaffner, M. Langemark, Paul M. Copeland, Paul E. Garfinkel, Elzbieta Kobylinska, M. Stubgaard, L. Eplov, G.F. Huon, G.G. Lloyd, A. Blaser, P.W. Jepsen, P. Bech, Owen S. Surman, Jennifer Holliday, Benedict Cosimi, and Thomas Garrick

Subjects
Psychiatry and Mental health, Clinical Psychology, General Medicine, Applied Psychology
Published
1987
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30. Tumor Associated Antigen with Pulmonary Neoplasms

Author

Frederic P. Herter, H.J. Hansen, P Lo Gerfo, and Jonathan Braun

Subjects
Lung Neoplasms, Colon, Radioimmunoassay, CA 15-3, Tumor M2-PK, Adenocarcinoma, Antigen-Antibody Reactions, Fetus, Text mining, Antigens, Neoplasm, Pregnancy, Iodine Isotopes, Pulmonary neoplasms, Humans, Medicine, Antigens, Carcinoma, Small Cell, Lung, business.industry, Carcinoma, Precipitin Tests, Tumor associated antigen, Carcinoma, Bronchogenic, Carcinoma, Squamous Cell, Cancer research, Female, Surgery, business, Digestive System, Research Article
Published
1972
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31. Tumor-associated antigen in patients with carcinoma of the colon

Author

P.Lo Gerfo, F.Lo Gerfo, Frederic P. Herter, H.J. Hansen, and Harold G. Barker

Subjects
Pathology, medicine.medical_specialty, Gastrointestinal tract, biology, business.industry, Radioimmunoassay, CA 15-3, General Medicine, medicine.disease, Carcinoembryonic antigen, Antigen, Antigens, Neoplasm, Iodine Isotopes, Macrophage-1 antigen, Colonic Neoplasms, biology.protein, Carcinoma, medicine, Humans, Surgery, Antigens, Antibody, business
Abstract

In 1965 Gold and Freedman [1,2] described an antigen isolated from saline extracts of colonic adenocarcinema. They called this antigen carcinoembryonic antigen (CEA) because of its distribution in neoplastic tissue of gastrointestinal origin and in the embryonic gastrointestinal tract. It was characterized by Krupey, Gold, and Freedman [3] as a protein polysaccharide complex soluble in 1.0 M perchloric acid (PCA) and 50 per cent saturated ammonium sulfate, and they have also reported its amino acid and carbohydrate composition. A radioimmunoassay procedure has been developed by Thomson et al [5] to detect and measure circulating antigen in the serum of patients. They demonstrated circulating CEA in a high percentage of patients with primary gastrointestinal neoplasms but they could not detect this antigen in patients with other types of primary neoplasms [5]. An antigen thought to be identical to CEA has been reported by Von Kleist and Burtin [4]. Serologic studies by Gold demonstrated antibodies to CEA in pregnant women and in a high percentage of patients with digestive system neoplasms both with and without metastases. For the past three years we have been attempting, in our laboratory, to further define the nature and significance of CEA as defined by Gold and Freedman [1,2]. Using both their reagents and methods and

Published
1972
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32. Subcellular localization of rodent and of monkey intrinsic factor

Author

H.J. Hansen and S.L. Salhi

Subjects
Intrinsic Factor, Centrifugation, Biology, Cycloheximide, Cytoplasmic Granules, digestive system, General Biochemistry, Genetics and Molecular Biology, Mice, chemistry.chemical_compound, Animals, General Pharmacology, Toxicology and Pharmaceutics, Differential centrifugation, Intrinsic factor, Haplorhini, General Medicine, Zymogen granule, Subcellular localization, biology.organism_classification, Mitochondria, Rats, Cell biology, chemistry, Gastric Mucosa, Dactinomycin, Lysosomes, Intracellular
Abstract

The intracellular distribution of rodent IF and monkey IF was studied by differential centrifugation. Intrinsic factor of rat and mouse is concentrated in granules similar to the zymogen granules which contain pepsinogen. In contrast, in the monkey IF is concentrated in the mitochondrial-lysosomal fraction.

Published
1969
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34. [20] Use of zirconyl phosphate gel for the separation of antigens from antigen—antibody complexes in radioimmunoassays: Assays for carcinoembryonic antigen, α-fetoprotein, and insulin

Author

J.W. Coffey, E.R. Sauerzopf, J.P. Vandevoorde, and H.J. Hansen

Subjects
Antigen-Antibody Complex, Carcinoembryonic antigen, Chromatography, Isoelectric point, biology, Antigen, Biochemistry, Chemistry, Reagent, biology.protein, Radioimmunoassay, Antibody, Alpha-fetoprotein
Abstract

Publisher Summary This chapter discusses the use of zirconyl phosphate gel (Z-gel) for the separation of antigens from antigen–antibody complexes in radioimmunoassay. Z-gel is a convenient and inexpensive reagent for the separation of free antigen from antigen-antibody complexes in certain radioimmunoassays. Z-gel can be used theoretically to separate a variety of antigens from their antibody complexes provided certain conditions can be satisfied— that is, if a pH can be found, at which the antigen and its antibody complex carry opposite net charge. Z-gel is a negatively charged gel at pH 6.25; it binds positively charged molecules, for example, proteins at a pH below their isoelectric pH. In the three radioimmunoassays described in this chapter, Z-gel at a pH of 6.25 is used to adsorb the positively charged antibody molecules (p I > 7), with their associated antigens, while leaving the negatively charged free antigens (CEA, AFP, and insulin) in solution. It has been shown that NH4 + is the preferred cation as Na + and K + decrease the ability of Z-gel to adsorb antigen–antibody complexes. In the chapter, are also described examples of radioimmunoassays, in which Z-gel has been used successfully, such as assays for carcinoembryonic antigen (CEA), α-fetoprotein (AFP), and insulin.

Published
1980
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35. [219] Assay of antiintrinsic factor antibodies

Author

H.J. Hansen, G.D. Frentz, and E. Jacob

Subjects
Vitamin b, Intrinsic factor, biology, Biochemistry, Chemistry, biology.protein, medicine, Zirconyl phosphate gel, Antibody, medicine.disease, pernicious anemia
Abstract

Publisher Summary This chapter discusses the assay method of antiintrinsic factor antibodies. Two antiintrinsic factor autoantibodics have been found in serum of many patients who have pernicious anemia. One of these antibodies, combining site antibody (CSAB), blocks the vitamin B 12 combining site of the intrinsic factor molecule. The second antibody, complex antibody (CAB), reacts with the intrinsic factor-vitamin B 12 complex (IF-B 12 ). The zirconyl phosphate gel (Z-gel) technique has proved to be the most useful for detection of both antibodies. At pH 5 zirconyl phosphate gel binds intrinsic factor or intrinsic factor-vitamin B 12 complex but does not bind free vitamin B 12 . Thus, blocking of B 12 binding by CSAB is easily measured. Gel of pH 6.25 does not bind free vitamin B 12 or IF-B 12 complex, but it does bind CAB-IF-B 12 complex. Also, by using standardized serum, either technique may be used to quantitate the intrinsic factor concentration of gastric juice. Other vitamin B 12 binders present in gastric juice do not react with either antibody.

Published
1971
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36. Studies on the binding of 6-mercaptopurine by ribonucleic acids in the presence of metals

Author

H.J. Hansen, S.B. Nadler, and S.J. Bennett

Subjects
Chemistry, Mercaptopurine, Inorganic chemistry, Extraction (chemistry), Biophysics, RNA, chemistry.chemical_element, Biochemistry, Copper, Yeast, Biophysical Phenomena, Ion, chemistry.chemical_compound, Metals, Nucleic acid, Molecular Biology, Hypoxanthine, Nuclear chemistry, Methyl group
Abstract

6-MP-S 35 combines with yeast RNA when they are mixed at room temperature. Extraction with hot TCA does not remove copper or 6-MP-S 35 from the nucleic acid. Treatment with H 2 S removes about 50% of the nucleic acid copper and 50% of the combined 6-MP-S 35 . Addition of copper ions to nucleic acid solutions increases the amount of 6-MP binding by the nucleic acid, and hot TCA extraction removes the extra 6-MP bound by added copper ions but does not remove 6-MP bound in the absence of added copper. When the SH group of 6-MP is blocked with a methyl group, combination with RNA does not occur. Adenine and hypoxanthine do not combine with RNA. The effect of copper ions on the spectra of 6-MP and some of its analogs is reported.

Published
1962

37. A radioimmunoassay for plasma insulin using zirconyl phosphate gel

Author

J.W. Coffey, Nagy Christa Fiedler, H.J. Hansen, and Ruth Lenusky

Subjects
medicine.medical_treatment, Insulin Antibodies, Guinea Pigs, Radioimmunoassay, Zirconyl phosphate gel, Antigen-Antibody Complex, Biochemistry, Chromatography, DEAE-Cellulose, Phosphates, Iodine Radioisotopes, Blood plasma, medicine, Free insulin, Methods, Animals, Insulin, Immunoreactive insulin, Chromatography, Chemistry, Human plasma, Evaluation Studies as Topic, Chromatography, Gel, Cattle, Zirconium, Plasma insulin, Gels
Abstract

A procedure for the detection of immunoreactive insulin in human plasma is described. The procedure is a rapid radioimmunoassay (3 hr) which uses zirconyl phosphate gel (Z-gel) at a pH of 6.25 to adsorb antibody-bound insulin while leaving free insulin in solution. Thirty-two samples of human plasma which had been assayed for immunoreactive insulin using a commercially available assay (Pharmacia Fine Chemicals, Piscataway, NJ) were also assayed on a blind basis for immunoreactive insulin using the Z-gel technique. A statistical comparison of the data obtained by the two methods yielded a highly significant (P

Published
1974

38. LEVODOPA INEFFECTIVE IN MIGRAINE

Author

H.J. Hansen and E. Dupont

Subjects
Adult, Male, Levodopa, business.industry, Migraine Disorders, General Medicine, Middle Aged, medicine.disease, Bioinformatics, Dihydroxyphenylalanine, chemistry.chemical_compound, Migraine, chemistry, medicine, Humans, Female, business, medicine.drug
Published
1972
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39. Oral physiology

Author

H.J. Hansen

Subjects
Otorhinolaryngology, business.industry, Medicine, Surgery, business, General Dentistry, Humanities, Quintessence
Published
1983
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