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Jedes Jahr versterben mehr Frauen an einem Ovarialkarzinom als an einem Cervixkarzinom und Endometriumkarzinom zusammen. Da die Heilungschancen wesentlich besser sind, wenn die Erkrankung in einem fru

The data presented show different effects of prostaglandins on proliferation and cytotoxic effector functions of murine bone-marrow derived mononuclear cells. Colony stimulating factor (CSF)-dependent proliferation of colony forming unit-cells (CFU c) was inhibited by PGE1, PGE2 and PGB2. Lymphokine induced cytotoxicity and antibody mediated cytotoxicity (ADCC) of monocytes and macrophages were also affected by PG. We conclude that PGE2 may regulate macrophage mediated tumorcell-lysis mainly at the induction phase. If there processes function in vivo, one would therefore expect high affinity binding sites for PGE2 on macrophages. The existence of a receptor for PGE2 one murine bone marrow derived macrophages is described.

Tissue contents of prostaglandins (PG) PGE 2 , PGE 2a and 6-keto-PGF 1a (degradation product of PGI 2 ) were determined in specimens of advancedhuman ovarian cancer (n=11). The PG levels (ng/mg tissue protein) varied widley: PGE 2 17–515; PGF 2a 2–43 and 6-keto-PGF 1a 5–105. Tumors of patients without response to chemotherapy contained more PGE 2 , PGF 2a and 6-keto-PGF 1a than did tumors responding to chemotherapy. PG production was investigated in two ovarian carcinoma-derived cell lines. The ability of these cells to synthesize PG varied depending on the cell density. An increase of cell number was associated with a decrease of PG yield. PG formation was inhibited by indomethacin in a concentration-dependent manner. The present study suggests that ovarian carcinoma cells form PG in vivo and vitro.