1. Occupational lung cancer risk among men in the Netherlands
- Author
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H.F. Balder, L. Preller, R.A. Goldbohm, Erik Tielemans, P.A. van den Brandt, and TNO Kwaliteit van Leven
- Subjects
optical instrumentation ,Male ,food intake ,Lung Neoplasms ,Time Factors ,proportional hazards model ,cancer risk ,Rate ratio ,railway employee ,Vegetables ,vegetable ,Occupational lung disease ,blue collar worker ,Prospective cohort study ,statistical significance ,Netherlands ,industry ,adult ,Smoking ,article ,risk assessment ,Middle Aged ,cohort analysis ,Occupational Diseases ,aged ,priority journal ,risk factor ,Health ,employment ,Risk assessment ,prospective study ,Cohort study ,lifestyle ,medicine.medical_specialty ,Alcohol Drinking ,alcohol consumption ,Food and Chemical Risk Analysis ,smoking habit ,building industry ,Occupational Exposure ,medicine ,follow up ,Humans ,Industry ,human ,Risk factor ,Lung cancer ,Aged ,business.industry ,Public Health, Environmental and Occupational Health ,fruit ,Feeding Behavior ,medicine.disease ,major clinical study ,Surgery ,lung cancer ,confidence interval ,Fruit ,Attributable risk ,incidence ,electronics industry ,Food Habits ,Epidemiologic Methods ,business ,occupational lung disease ,Demography - Abstract
Objectives: To assess male lung cancer risks for industrial sectors in the Netherlands and to estimate the proportion of lung cancer attributed to working in specific industrial sectors. Methods: Associations were studied among men aged 55-69 years (n = 58 279) from the prospective Netherlands Cohort Study. 1920 incident lung cancer cases were available after 11.3 years of follow-up. Based on a case-cohort design, and using Cox proportional hazards models, risks were estimated for blue collar workers in 26 industrial sectors. Results: Adjustment for individual smoking habits affected risk estimates for some sectors, but adjustment for fruit/vegetables and alcohol intake did not. Adjusted for confounders, an increased risk of lung cancer was observed for employment for ≥15 years in blue collar jobs in the "electronics and optical instruments" industry (rate ratio (RR) 1.99; 95% CI 1.18 to 3.35), "construction and homebuilding business" (RR 1.64; 95% CI 1.21 to 2.22) and "railway company" (RR 2.40; 95% CI 1.00 to 5.73). The attributable fraction for working for ≥15 years in these three industries was 5%. In three other sectors there was a statistically non-significant elevated RR of >1.5. Conclusions: Male lung cancer risk is increased in several industrial sectors. Approximately 2000 lung cancer cases between 1986 and 1997 in the 55-69-year-old age group in the Netherlands may be attributable to working for ≥15 years in the three sectors with increased risk. In addition, estimates for occupational lung cancer risks for sectors may be biased if no individual information is available on smoking habits.
- Published
- 2008