522 results on '"H.-Y. Liu"'
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2. THE DEVELOPMENT AND VALIDATION OF A TACTICAL GRADE EGI SYSTEM FOR LAND VEHICULAR NAVIGATION APPLICATIONS
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Y.-E. Huang, S. Tsai, H.-Y. Liu, K.-W. Chiang, M.-L. Tsai, P.-L. Lee, and N. El-Sheimy
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Over recent years, the utilization of commercially available integrated navigation systems for the development of navigation algorithms has become increasingly commonplace. Nevertheless, the wide range of sensor quality on the market complicates system customization and restricts the evolution of navigation algorithms. This study aims to address these issues by creating an affordable, tactical-grade, real-time integrated navigation system, EGI-500 (Embedded GNSS and INS), encompassing both hardware and software components. EGI-500 incorporates a tactical-grade IMU500 and a Septentrio Mosaic-X5 GNSS receiver module. The integration process is segmented into three distinct stages. The first involves hardware integration, with an illustrative architecture diagram of the real-time navigation system. Second, we focus on data preprocessing, where a cross-correlation approach is proposed to tackle multi-sensor time synchronization issues, specifically to determine potential time lags in IMU data. The final phase covers the fusion of multi-sensor data and motion constraints. The Extended Kalman Filter (EKF) forms the backbone of this part, with Zero Velocity Update (ZUPT) and Non-Holonomic Constraints (NHC) being integrated into the Loosely Coupled (LC) scheme. Furthermore, the IMU calibration process is performed to ascertain necessary algorithmic parameters. Experimental results, conducted in diverse environments (open sky, GNSS challenging, and GNSS denied), will be presented in this paper. Comparisons with reference data indicate that the navigation accuracy of the developed integrated system, both in terms of hardware and navigation algorithm, achieves expected meter-level accuracy, fulfilling the "Which Lane" and "Which Road" level criteria in varied environments. Furthermore, outcomes from the GNSS denied environment align with predictions based on propagation error theory, demonstrating the feasibility of our navigation algorithm for tactical integrated navigation systems.
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- 2023
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3. THE DEVELOPMENT AND VALIDATION OF A NAVIGATION GRADE EGI SYSTEM FOR LAND VEHICULAR NAVIGATION APPLICATIONS
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Y.-E. Huang, S. Tsai, H.-Y. Liu, K.-W. Chiang, M.-L. Tsai, P.-L. Lee, and N. El-Sheimy
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
In recent years, most people use commercial integrated navigation systems to develop navigation algorithms. However, due to the different levels of sensors on the market, it is difficult to customize commercial systems and leads to limited development of navigation algorithms. Therefore, the purpose of this research is to develop a real-time integrated navigation system EGI-1000 (Embedded GNSS and INS) including software and hardware, and effectively reduce the cost with the commercial price. The real-time integrated navigation system EGI-1000 contains a navigation-grade IMU, IMU1000 and NovAtel OEM 7720 GNSS receiver module. In this research, the integration process can be divided into three parts. The first part is the integration of hardware, and the architecture diagram of the real-time integrated navigation system will be displayed. The second part is the pre-processing of data. In the multi-sensor time synchronization problem, this research will propose a method about cross-correlation to validate whether the timestamp of IMU data is delay. The last part is algorithm about fusing data from multiple sensors and motion constraints. Extended Kaman Filter (EKF) will be the core and motion constraints including Zero Velocity Update (ZUPT) and Non-Holonomic Constraints (NHC) are integrated in the Loosely Coupled (LC) scheme. The calibration of Inertial navigation Measurement Unit (IMU) will also be conducted to determine the parameter in algorithm. The results of the experiments will be shown in this paper. Both of hardware and navigation algorithm in the integrated navigation system of this research are used to conduct multiple experiment including open sky environments, GNSS challenging environments, and GNSS denied environment. In comparison with the reference data, the navigation accuracy of the developed integrated navigation system can achieve centimeter-level accuracy (“Active Control” level and “Where in lane” level) in open sky and GNSS challenging environments. According to the propagation error theory, the result in GNSS denied environment also meet the expected value. The navigation algorithm is also feasible for the commercial integrated navigation system.
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- 2023
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4. AN INITIAL ALIGNMENT METHOD OF INERTIAL NAVIGATION SYSTEM FOR THE STATIC STATE
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H.-Y. Liu, S. Tsai, M.-L. Tsai, and K.-W. Chiang
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
The navigation means the process of determining the position, velocity, and orientation of the moving object such as the land vehicle, aerial vehicle, and even autonomous vehicle. Nowadays, Global Navigation Satellite System (GNSS) is most used for positioning. Nevertheless, the navigation system based on GNSS would be interrupted in the challenging environments. Therefore, the inertial navigation system (INS) has been widely combined with GNSS to overcome this issue. For INS, the core concept is the measurements of Inertial Measurement Unit (IMU). In order to integrate the measurements of IMU with several sensors such as GNSS receivers, odometers, and so on, we should transform the measurements of IMU from body frame to navigation frame. The initial alignment just represents the process of finding the accurate initial rotation matrix between body frame and navigation frame in the beginning of navigation. However, initial misalignment angles would cause large error of INS. Hence, obtaining an accurate initial rotation matrix from body frame to navigation frame is an important issue to get the better navigation performance. In the research, an integrated navigation system is developed to validate the initial alignment algorithm. With the data pre-processing and accurate calibration. the proposed method of initial alignment can get precise initial ration matrix. The errors of roll pitch, and yaw angle are all smaller than 1 degree after initial alignment. Moreover, the time threshold of initial alignment is set by manual traditionally. A method of finding threshold of coarse alignment is proposed in this research.
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- 2022
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5. A new species group defined in Lycocerus Gorham (Coleoptera, Cantharidae), with description of a new species from Xizang, China
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H. C. Xi, Y. N. Wang, X. K. Yang, H. Y. Liu, and Y. X. Yang
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New combination ,reinstated status ,new species ,new faunistic record ,phylogenetic analysis ,Zoology ,QL1-991 - Abstract
The Lycocerus varipubens species-group is defined to accommodate three previously described species and a new species from the Himalayan area, including L. varipubens, L. semiextensus, L. purpurascens comb. nov. & stat. reinst. and L. zayuensis sp. nov. L. purpurascens, originally described in Cantharis and first combined in Lycocerus here, is reinstated as a valid specific name to replace L. rubrispinis syn. nov., which is a replacement name for Cantharis rubripennis. Meanwhile, L. rubrispinis becomes a junior synonym of L. purpurascens. L. varipubens species-group could be distinguished from all other groups by the combination of following characters, the filiform antennae, pronotum wider than long, reddish-brown elytra with weakly or moderately developed longitudinal costae, all pro- and meso-outer claws each with a digtiform tooth in both sexes, and spermatheca with three spiral tubes. The species descriptions are provided with habitus photos, aedeagi, abdominal sternites VIII and reproductive systems of female. L. purpurascens and L. varipubens are recorded to China for the first time. In addition, a morphological phylogenetic analysis shows that the L. varipubens group is sister to L. purpureus group. A distribution map and a key to the species of this species-group are also provided.http://www.zoobank.org/urn:lsid:zoobank.org:pub:7C82B6E4-9A71-4893-AD97-5692839D2236
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- 2022
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6. Outcomes of fracture-related infections – do organism, depth of involvement, and temporality count?
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Janus S H Wong, Alfred L H Lee, Christian Fang, Henry C H Leung, Alicia H Y Liu, Ryan C K So, Colin S Y Yung, Tak-Man Wong, and Frankie Leung
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Orthopedic surgery ,RD701-811 - Abstract
Purpose: To determine mortality and outcomes of patients diagnosed with fracture-related infections (FRIs). Methods: FRI patients treated at a trauma centre between 2001 and 2020 were analysed. The primary outcome was 1-year mortality; mortality associations with FRI organism, depth of involvement, and temporality were investigated with multivariable survival analysis. Healthcare-associated and serological outcomes were reported as secondary outcomes. Results: 311 FRIs with mean age of 67.0 and median Charlson comorbidity index of 0 were analysed. Methicillin-sensitive Staphylococcus aureus (MSSA) (29.9%) was the most frequently implicated organism. The majority of FRIs were deep infections (62.7%). FRIs were diagnosed at a median of 40 (IQR 15–200) days post index surgery. The mean follow-up was 5.9 years. One-year mortality amounted to 17.7%. MSSA FRIs were associated with better survival (adj HR 0.34, 95%CI 0.15–0.76, p = 0.008). There was no difference in survivorship between deep or superficial FRI (adj HR 0.86, 95%CI 0.62–1.19, p = 0.353) or in relation to onset time (adj HR 1.0, 95%CI 0.99–1.00, p = 0.943). Implant removal or debridement alone was performed in 61.7% and 17% respectively. Antibiotics was prescribed for 53 (IQR 23–110) days, and patients were hospitalised for 39 (IQR 19–78) days. CRP and ESR normalised in 70.3% (median 46 days) and 53.8% (median 86 days) patients respectively. Conclusion: Fracture-related infections are associated with significant mortality and morbidity regardless of depth and temporality. Non-MSSA FRIs are associated with inferior survival.
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- 2022
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7. STREET TREE INFORMATION EXTRACTION AND DYNAMICS ANALYSIS FROM MOBILE LIDAR POINT CLOUD
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Y. Q. Li, H. Y. Liu, Y. K. Liu, S. B. Zhao, P. P. Li, and W. Xiao
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Street trees are common features and important assets in urban scenes. They are huge in numbers and are constantly changing, thus are difficult to monitor on a regular basis. A method of automatic extraction and dynamic analysis of street trees based on mobile LiDAR data is proposed. First, ground and low objects are filtered from the point clouds. Then, based on a geometric tree model and semantic information, each tree point cloud is extracted, and geometrical parameters such as location, trunk diameter, trunk structure line, tree height, crown width, and crown volume of each tree is obtained. A dynamic analysis combined with the growing characteristics of trees is conducted to compare and analyse the street trees from different epochs, in order to understand whether the trees have grown or been pruned, replanted, or displaced. The proposed algorithm was tested on three epochs of mobile LiDAR data, obtained in 2010, 2016 and 2018, respectively. Experimental results showed that the proposed method was able to accurately detect trees and extract tree parameters for detailed dynamics analysis.
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- 2020
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8. Abnormal keratin expression pattern in prurigo nodularis epidermis
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L. L. Yang, B. Jiang, S. H. Chen, H. Y. Liu, T. T. Chen, L. H. Huang, M. Yang, J. Ding, J. J. He, J. J. Li, and B. Yu
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Dermatology ,RL1-803 - Abstract
Abstract Background Prurigo nodularis (PN) is a highly pruritic, chronic dermatosis and difficult to treat. PN lesions are characterized by existence of many hyperkeratotic, erosive papules and nodules. However, the pathogenesis of PN still remains unelucidated. Aim To clarify the keratin role in the epidermis hyperproliferation, the keratin expression pattern in the PN lesional skin. Methods In this study, we enrolled 24 patients with PN and 9 healthy control volunteers. K1/K10, K5/K14, K6/K16/K17 expression pattern were investigated by using immunohistochemical staining. Results The lesional skin consists of the thickened spinous layers, in which active cell division was found. K5/K14 were upregulated in PN lesional epidermis, the staining signal localized in the basal layer and lower suprabasal layers. Hyperproliferation‐associated K6 was found in all layers of epidermal lesional skin, especially in the spinous layers. In contrast, K16 was only detected in the basal and lower suprabasal layers, K17 was observed in the basal and spinous layers. Terminal differential keratins K1/K10 were upregulated, detected in the pan‐epidermis, but spared in the basal and low suprabasal layers. Conclusion The keratinocytes enter an alternative differentiation pathway, which are responsible for the activated keratinocyte phenotype, abnormal keratins expression potentially contributes to the keratinocytes proliferation, subsequently lead to increased lesional skin epidermis thickness, hyperkeratiosis and alteration of skin barrier properties.
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- 2022
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9. Two-step treatment to obtain single-terminated SrTiO3 substrate and the related difference in both LaAlO3 film growth and electronic property
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J. J. Peng, C. S. Hao, H. Y. Liu, and Y. Yan
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Physics ,QC1-999 - Abstract
A two-step treatment, first chemical etching then thermal treatment, is proposed to achieve an atomically flat and thermally stable TiO2-terminated SrTiO3 substrate. LaAlO3 films were then grown on those TiO2-terminated and as-received substrates. LaAlO3 films on the TiO2-terminated SrTiO3 substrate maintained the layer-by-layer growth mode with a sharp interface, while films on the as-received substrates easily underwent reconstruction adverse to the sharp interface. Both LaAlO3/SrTiO3 interfaces displayed metallic conductive behavior, while the difference in magnetotransport properties indicated the difference in origin for interface conductivity. Large positive magnetoresistance implied that the LaAlO3/as-received substrate interface was a 3D conductive interface dominated by oxygen vacancies. However, the annealed-LaAlO3/treated-substrate interface preserved intrinsic quasi-2D interface magnetism as evidenced by large negative magnetoresistance.
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- 2021
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10. Synthesis, structure, magnetic and half-metallic properties of Co2−xRuxMnSi (x = 0, 0.25, 0.5, 0.75, 1) compounds
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H. P. Zhang, W. B. Liu, X. F. Dai, X. M. Zhang, H. Y. Liu, X. Yu, and G. D. Liu
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half-metals ,electrical transport ,structural properties ,Crystallography ,QD901-999 - Abstract
A series of Co2−xRuxMnSi (x = 0, 0.25, 0.5, 0.75, 1) Heusler compounds were successfully synthesized. The heat-treatment conditions were crucial to make the materials form a single phase with a Heusler structure. With increasing Ru content, the half-metallic gap, lattice parameters and magnetization are continuously adjustable in a wide range. The Co2−xRuxMnSi (x = 0, 0.25) compounds are rigorous half-metals and show a T3 dependence of resistance at low temperature. The Co2−xRuxMnSi (x = 0.5, 0.75, 1) Heusler compounds are the nearly half-metallic materials and show a semiconductive dependence of resistance at low temperature. The experimental magnetization is consistent with that in theory and follows the Slater–Pauling rule. The Curie temperature is higher than 750 K for all Co2−xRuxMnSi Heusler compounds.
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- 2020
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11. Screening topological materials with a CsCl-type structure in crystallographic databases
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L. Jin, X. M. Zhang, X. F. Dai, L. Y. Wang, H. Y. Liu, and G. D. Liu
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CsCl-type materials ,crystal structures ,electronic structures ,first-principles calculations ,inorganic materials ,density functional theory ,topological modeling ,Crystallography ,QD901-999 - Abstract
CsCl-type materials have many outstanding characteristics, i.e. simple in structure, ease of synthesis and good stability at room temperature, thus are an excellent choice for designing functional materials. Using high-throughput first-principles calculations, a large number of topological semimetals/metals (TMs) were designed from CsCl-type materials found in crystallographic databases and their crystal and electronic structures have been studied. The CsCl-type TMs in this work show rich topological character, ranging from triple nodal points, type-I nodal lines and critical-type nodal lines, to hybrid nodal lines. The TMs identified show clean topological band structures near the Fermi level, which are suitable for experimental investigations and future applications. This work provides a rich data set of TMs with a CsCl-type structure.
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- 2019
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12. Master-Slave System Research of a Vascular Interventional Surgical Robot.
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H. Y. Yu, H. B. Wang, W. Zhang, H. Y. Liu, J. Y. Chang, and D. Huang
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- 2018
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13. Effects of Landslides on the Displacement of a Bridge Pile Group Located on a High and Steep Slope
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Y. F. Zhang, J. Li, W. Li, J. M. Li, and H. Y. Liu
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Engineering practice shows that the deformation of the slide-resistant pile may be transferred to the adjacent bridge foundation on an inclined slope, which can compromise the safety of the entire bridge. However, this phenomenon has rarely been considered in the past. To reveal the deformation transfer mechanism between the slide-resistant pile and the adjacent structures, a full-scale field test was performed on a high and steep slope located in a section of a certain railway. A numerical analysis model was constructed to simulate the field test and validate its parameters. Moreover, parametric analysis was also conducted to examine the influence of the pile length, pile diameter, and arrangement of the pile foundation. The results show that the bridge pile foundation is simultaneously affected by the “load transfer effect” caused by the slide-resistant pile and “traction effect” of the sliding slope. With the distance between the pile foundation and the slide-resistant pile increasing, the dominant factor affecting the deformation mode of the pile body is switched from the “load transfer effect” to the “traction effect.” Furthermore, a critical embedment depth exists for the bridge pile foundation built on a high and steep slope, which varies at different locations along the inclined stratum. In addition, using a pile arrangement with a larger pile diameter and lower number of piles is more beneficial for controlling the horizontal displacement of the bridge foundation. The results of the research provide a reference for the safety control of the engineering on the high and steep slope.
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- 2021
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14. Properties of Polyborate Ions by DFT Calculation
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W. Q. Zhang, Y. Q. Zhou, C. H. Fang, W. Li, F. Y. Zhu, H. Y. Liu, Y. Lv, G. G. Pang, N. Shan, Y. Y. Zhang, K. Bao, X. Y. Guo, and M. X. Xiao
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Physical and Theoretical Chemistry - Published
- 2022
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15. UAV swarm collaborative coverage control using GV division and planning algorithm
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H. Y. Liu, J. Chen, K. H. Huang, G. Q. Cheng, and R. Wang
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Aerospace Engineering - Abstract
Unmanned aerial vehicle (UAV) swarm coverage is one of the key technologies for multi-UAV cooperation, which plays an important role in collaborative investigation, detection, rescue and other applications. Aiming at the coverage optimisation problem of UAV in the target area, a collaborative visual coverage control method under positioning uncertainty is presented. First, the visual perception area with imprecise localisation, UAV model and sensor model are created based on the given task environment. Second, a regional division algorithm for the target task area is designed based on the principle of Guaranteed Voronoi (GV) diagram. Then a visual area coverage planning algorithm is designed, in which the task area is allocated to the UAV according to the corresponding weight coefficient of each area, and the input control law is adjusted by the expected state information of the UAV, so that the optimal coverage quality target value and the maximum coverage of the target area can be achieved. Finally, three task scenarios for regional division and coverage planning are simulated respectively, the results show that the proposed area coverage planning algorithm can realise the optimal regional distribution and can obtain more than 90% coverage in different scenarios.
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- 2022
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16. Clinical practice of traditional Chinese medicine for the treatment of postmenopausal osteoporosis: a literature review
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J. Li, S.-F. Fu, Y. Yang, R. An, H.-Y. Liu, and H.-P. Mao
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Databases, Factual ,Humans ,Obstetrics and Gynecology ,Female ,General Medicine ,Medicine, Chinese Traditional ,Drug Prescriptions ,Osteoporosis, Postmenopausal ,Drugs, Chinese Herbal - Abstract
This study aimed to evaluate the effectiveness and safety of traditional Chinese medicine (TCM) for postmenopausal osteoporosis (PMOP).We conducted a computer literature search in five databases and comprehensively extracted all kinds of information from each article. Traditional Chinese medicine inheritance support system (TCMISS) V2.5 was adopted to perform association analysis. The effectiveness, safety and methodological quality were analyzed using randomized controlled clinical trials (RCTs).A total of 2880 related articles were collected. Finally, 423 articles which included 312 RCTs were included for in-depth analysis. We collected 369 Chinese medicine prescriptions and found that the top three frequently used herbs in the treatment of PMOP wereiEpimedii Folium/i(Yinyanghuo),iRehmanniae Radix Praeparata/i(Shudihuang) andiAngelicae Sinensis Radix/i(Danggui). The top Chinese patent medicine was Gushukang capsule. No serious adverse reaction (AR) had been reported in the Chinese medical treatment group.The effectiveness of TCM in treating PMOP needs to be further explored, and the safety is good. Therefore, high-quality evidence is urgently needed to supplement.
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- 2022
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17. Control of the metal-to-insulator transition by substrate orientation in nickelates
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J. J. Peng, B. Ouyang, H. Y. Liu, C. S. Hao, S. S. Tang, Y. D. Gu, and Y. Yan
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Physics ,QC1-999 - Abstract
We proved that the critical thickness for metal-to-insulator transition (MIT) of LaNiO3 could be controlled by substrate orientation. By means of density functional theory calculations, films grown on SrTiO3 substrates with (001), (110) and (111) orientations have different amount of charge transfer across the interface. Different charge transfer induces different interfacial conductivity behavior and at the same time modifies the carrier density of adjacent LaNiO3 films. The manipulation of MIT by substrate orientation can be achieved through interfacial charge transfer induced interfacial conductive layer with the modified conductivity of LNO layer.
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- 2019
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18. Research on the Vibration Reduction Design of Camshaft Swing Grinding Based on Local Resonance Mechanism
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X. N. Shi, H. Y. Liu, L. Zhao, X. R. Wang, G. C. Li, H. G. Zhou, C. H. Lv, and K. L. Wang
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Mechanics of Materials ,General Physics and Astronomy - Published
- 2023
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19. The Effects of Dietary Phosphorus on the Growth Performance and Phosphorus Excretion of Dairy Heifers
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B. Zhang, C. Wang, Z. H. Wei, H. Z. Sun, G. Z. Xu, J. X. Liu, and H. Y. Liu
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Heifers ,Growth Performance ,Phosphorus ,Phosphorus Excretion ,Animal culture ,SF1-1100 ,Animal biochemistry ,QP501-801 - Abstract
The objective of this study was to investigate the effects of reducing dietary phosphorus (P) on the frame size, udder traits, blood parameters and nutrient digestibility coefficient in 8- to 10-month-old Holstein heifers. Forty-five heifers were divided into 15 blocks according to the mo of age and were randomly assigned one of three dietary treatments: 0.26% (low P [LP]), 0.36% (medium P [MP]), or 0.42% (high P [HP]) (dry matter basis). Samples were collected at the wk 1, 4, 8. The results show that low dietary P had no effect on body measurement. The blood P concentration decreased with decreasing dietary P (p
- Published
- 2016
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20. Constructing a Hierarchical Learning Cost Curve for Photovotaic System.
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Amy J. C. Trappey, Charles V. Trappey, Penny H. Y. Liu, Lee-Cheng Lin, and Jerry J. R. Ou
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- 2013
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21. Location Quotient EIO-LCA Method for Carbon Emission Analysis.
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Amy J. C. Trappey, Charles V. Trappey, Penny H. Y. Liu, Chih-Tung Hsiao, and Jerry J. R. Ou
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- 2012
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22. [A preliminary study on the construction and application of the smart classroom teaching mode in endodontics]
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Q M, Gong, S, Mai, J J, Quan, L J, Huang, H Y, Liu, and X, Wei
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Surveys and Questionnaires ,Humans ,Learning ,Students ,Dental Care ,Endodontics - Published
- 2022
23. Anion Induced Synthesis, Structural Characterization and Antibacterial Activity of Zinc(II) Complexes Derived from 5-Bromo-2-((2-(diethylamino)ethylimino)methyl) phenol
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H. Y. Liu, Qiao Chen, Zhi-Tao Li, Xiang Gan, and Jin-Yan Ding
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crystal structure ,Schiff base ,zinc complex ,chemistry.chemical_element ,self-assembly ,Zinc ,Crystal structure ,schiff base ,Medicinal chemistry ,Square pyramidal molecular geometry ,Chemistry ,chemistry.chemical_compound ,Trigonal bipyramidal molecular geometry ,antibacterial activity ,chemistry ,General Earth and Planetary Sciences ,Phenol ,Self-assembly ,Antibacterial activity ,QD1-999 ,General Environmental Science - Abstract
By changing the anions of zinc salts, three different zinc(II) complexes, [Zn 2 (HL) 2 (NCS) 4 ]·2CH 3 OH ( 1 ), [Zn 2 L( μ 2 - η 1 : η 1 -CH 3 COO) 2 (NCS)] ( 2 ) and [Zn(HL)I 2 ]·CH 3 OH ( 3 ), where L = 5-bromo-2-((2-(diethylamino)ethylimino)methyl)phenolate, HL = 5-bromo-2-((2-(diethylammonio)ethylimino)methyl)phenolate, have been synthesized and characterized by IR and UV-Vis spectroscopy, as well as single-crystal X-ray diffraction. X-ray analysis indicates that the Zn atoms in the complexes are in trigonal bipyramidal, square pyramidal and tetrahedral coordination. The anions of the zinc salts lead to the formation of different structures of the complexes. Antibacterial activity of the complexes against Staphylococcus aureus , Escherichia coli , Klebsielle pneumoniae and Candida albicans strains was studied.
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- 2021
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24. Multi-mode Interference Reflector based InAs-QD Laser
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F. T. Albeladi, S. Gillgrass, J. Nabialek, P. Mishra, R. Forrest, T. R. Albiladi, S. Shutts, M. Tang, H-Y. Liu, and P. M. Smowton
- Published
- 2022
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25. Honey combined with silver ion dressing in complicated chronic wound of the scalp: a case report
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J-Q, Lin, L-L, Yang, X, Yang, X-H, Zeng, Y, Zhang, Z-P, Li, and H-Y, Liu
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Wound Healing ,Scalp ,Silver ,Adolescent ,Humans ,Surgical Wound Infection ,Female ,Honey ,Burns ,Bandages - Abstract
Scalp wound healing is a complex process. Nonhealing wounds can become chronic wounds, which increase the trauma and economic burden on a patient and may even cause death in severe cases. Thus, it can be difficult to find an effective treatment for chronic wounds of the scalp.We present a case of a 13-year-old female patient with a chronic wound caused by a scalp incision infection 3 months after two operations for craniotomy for arachnoid cyst resection and cystic lesion-cisterna magna drainage. After repeated dressing changes and two debridement operations, the incision had still not healed during the following year. The wound finally healed after 6 months of dressing changes by combining honey with silver ion dressings, and the incision had not re-ruptured after 10 months of follow-up.Honey combined with silver may be an effective method for the treatment of chronic scalp wounds.
- Published
- 2022
26. Application of Remote Sensing in Training Geospatial Cognitive Abilities of Secondary Students.
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Li Wu, H. Y. Liu, and P. Peng
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- 2014
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27. Waveguide Mach-Zehnder interferometer to enhance the sensitivity of quantum parameter estimation
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X. N. Feng, H. Y. Liu, and L. F. Wei
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Atomic and Molecular Physics, and Optics - Abstract
The waveguide Fabry-Perot interferometer (FPI) (see, e.g., in Phys. Rev. Lett. 113, 243601 (2015)10.1103/PhysRevLett.115.243601 and Nature 569, 692 (2019)10.1038/s41586-019-1196-1), instead of the free space's one, have been demonstrated for the sensitive quantum parameter estimations. Here, we propose a waveguide Mach-Zehnder interferometer (MZI) to further enhance the sensitivity of the relevant parameter estimations. The configuration is formed by two one-dimensional waveguides coupled sequentially to two atomic mirrors, which are served as the beam splitters of the waveguide photons to control the probabilities of the photons being transferred from one waveguide to another. Due to the quantum interference of the waveguide photons, the acquired phase of the photons when they pass through a phase shifter can be sensitively estimated by measuring either the transmitted or reflected probabilities of the transporting photons. Interestingly, we show that, with the proposed waveguide MZI the sensitivity of the quantum parameter estimation could be further optimized, compared with the waveguide FPI, in the same condition. The feasibility of the proposal, with the current atom-waveguide integrated technique, is also discussed.
- Published
- 2023
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28. SYNTHESES, CHARACTERIZATION, AND ANTIBACTERIAL PROPERTIES OF COPPER(II) COMPLEXES DERIVED FROM FLUORO-CONTAINING SCHIFF BASES
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M. Z. Zhou, H. Y. Liu, and N. Wang
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Inorganic Chemistry ,chemistry.chemical_compound ,Deprotonation ,Chemistry ,Materials Chemistry ,chemistry.chemical_element ,Phenol ,Physical and Theoretical Chemistry ,Copper ,Single crystal ,Medicinal chemistry ,Square pyramidal molecular geometry - Abstract
A centrosymmetric dinuclear copper(II) complex [Cu2(La)2] (1) and two mononuclear copper(II) complexes [Cu(Lb)2] (2) and [Cu(Lc)2] (3), where La, Lb, and Lc are deprotonated anionic forms of 2-((cyclopropylimino)methyl)-4,6-difluorophenol (HLa), 2-((cyclohexylimino)methyl)-4,6-difluorophenol (HLb) and 2,4-difluoro-6-((2-hydroxyethylimino)methyl)phenol (HLc), respectively, are prepared and characterized by elemental analyses, IR and UV-Vis spectra, and single crystal X-ray diffraction. The Cu atoms in complex 1 are in a square pyramidal coordination, while those in complexes 2 and 3 are in a square planar coordination. The complexes exhibit interesting antibacterial activities against P. aeruginosa, S. typhi, and S. aureus.
- Published
- 2021
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29. [Early warning of low maternal unconjugated estriol level by prenatal screening for fetus with X-linked ichthyosis]
- Author
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H Y, Liu, J, Li, D R, Huang, K, Feng, J H, Liu, Q N, He, K Y, Guo, G Y, Ding, Y, Lou, and Yue, Wang
- Subjects
Male ,Estriol ,Infant, Newborn ,Ichthyosis ,Trisomy ,Chorionic Gonadotropin ,Fetus ,Pregnancy ,Pregnancy Trimester, Second ,Prenatal Diagnosis ,Humans ,Female ,alpha-Fetoproteins ,Down Syndrome ,Trisomy 18 Syndrome ,Retrospective Studies - Published
- 2022
30. In Vivo Regional De-Epithelialization and Recellularization in a Xeno-Transplant Model
- Author
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C. Predella, H.-Y. Liu, S. Liang, Y.-W. Chen, G. Vunjak-Novakovic, N.V. Dorrello, and H. Snoeck
- Published
- 2022
- Full Text
- View/download PDF
31. Spin polarization in a two-dimensional electron gas modulated by ferromagnetic and Schottky metal stripes.
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J. D. Lu and H. Y. Liu
- Published
- 2011
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32. Characteristics of concentrations and chemical compositions for PM2.5 in the region of Beijing, Tianjin, and Hebei, China
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P. S. Zhao, F. Dong, D. He, X. J. Zhao, X. L. Zhang, W. Z. Zhang, Q. Yao, and H. Y. Liu
- Subjects
Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
In order to study the temporal and spatial variations of PM2.5 and its chemical compositions in the region of Beijing, Tianjin, and Hebei (BTH), PM2.5 samples were collected at four urban sites in Beijing (BJ), Tianjin (TJ), Shijiazhuang (SJZ), and Chengde (CD), and also one site at Shangdianzi (SDZ) regional background station over four seasons from 2009 to 2010. The samples were weighted for mass concentrations and analyzed in the laboratory for chemical profiles of 19 elements (Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Ni, P, Pb, Sr, Ti, V, and Zn), eight water-soluble inorganic ions (Na+, NH4+, K+, Mg2+, Ca2+, Cl−, NO3−, and SO42−, and carbon fractions (OC and EC). The concentrations of PM2.5 and its major chemical species were season dependent and showed spatially similar characteristics in the plain area of BTH. The average annual concentrations of PM2.5 were 71.8–191.2 μg m−3 at the five sites, with more than 90% of sampling days exceeding 50 μg m−3 at BJ, TJ, and SJZ. PM2.5 pollution was most serious at SJZ, and the annual concentrations of PM2.5, secondary inorganic ions, OC, EC, and most crustal elements were all highest. Due to stronger photochemical oxidation, the sum of concentrations of secondary inorganic ions (NH4+, NO3−, and SO42− was highest in the summer at SDZ, BJ, TJ, and CD. Analysis of electric charges of water-soluble inorganic ions indicated the existence of nitric acid or hydrochloric acid in PM2.5. For all five sites, the concentrations of OC, EC and also secondary organic carbon (SOC) in the spring and summer were lower than those in the autumn and winter. SOC had more percentages of increase than primary organic carbon (POC) during the winter. The sums of crustal elements (Al, Ca, Fe, Mg, Ti, Ba, and Sr) were higher in the spring and autumn owing to more days with blowing or floating dust. The concentrations of heavy metals were at higher levels in the BTH area by comparison with other studies. In Shijiazhuang and Chengde, the PM2.5 pollution was dominated by coal combustion. Motor vehicle exhausts and coal combustion emissions both played important roles in Tianjin PM2.5 pollution. However, motor vehicle exhausts had played a more important role in Beijing owing to the reduction of coal consumption and sharp increase of cars in recent years. At SDZ, regional transportation of air pollutants from southern urban areas was significant.
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- 2013
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33. Empirical bond order potential calculations of the elastic properties of epitaxial InGaSbAs layers.
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Vesel Haxha, Raman Garg, Max A. Migliorato, I. W. Drouzas, José María Ulloa, P. M. Koenraad, M. J. Steer, H. Y. Liu, Mark Hopkinson, and D. J. Mowbray
- Published
- 2009
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34. Comparative assessment of gut microbial composition and function in patients with Graves’ disease and Graves’ orbitopathy
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Y.-L. Yang, Ting-Ting Shi, R.-R. Xie, Zhong Xin, Jin-Kui Yang, Lin Hua, H.-Y. Liu, H. Wang, and R.-X. Zhao
- Subjects
food.ingredient ,Endocrinology, Diabetes and Metabolism ,Clostridiales ,Graves' disease ,Lachnospiraceae ,030209 endocrinology & metabolism ,Biology ,Gut flora ,medicine.disease ,biology.organism_classification ,Microbiology ,03 medical and health sciences ,Metabolic pathway ,0302 clinical medicine ,Endocrinology ,food ,Chloroflexi (class) ,Anaerostipes ,030220 oncology & carcinogenesis ,medicine ,Feces - Abstract
A previous study indicated that gut microbiota changed notably in Graves’ orbitopathy (GO) patients as compared to controls. However, the characteristics of intestinal bacteria in Graves’ disease (GD) and GO are unclear. The present study aimed to identify specific intestinal bacteria of GD and GO, respectively. The gut microbial communities of the fecal samples of 30 GD patients without GO, 33 GO subjects, and 32 healthy subjects were analyzed and compared by 16S rRNA gene sequencing. At the phylum level, the proportion of Deinococcus-Thermus and Chloroflexi was decreased significantly in GO patients as compared to GD. At the genus level, the proportion of Subdoligranulum and Bilophila was increased while that of Blautia, Anaerostipes, Dorea, Butyricicoccus, Romboutsia, Fusicatenibacter, unidentified_ Lachnospiraceae, unidentified_Clostridiales, Collineslla, Intestinibacter, and Phascolarctobacterium was decreased in the GO group as compared to the GD group. Random forest analysis was used for the identification of specific intestinal microbiota, and Deinococcus-Thermus, Cyanobacteria and Chloroflexi were ranked in the top ten according to their contributions to sample classification. Moreover, compared to the control, there were multiple gut bacterial enrichment metabolic pathways in GO and GD patients, including nucleotide metabolism, enzyme family, and energy metabolism. Compared to GO, the only enrichment metabolic pathway found in GD was the viral protein family. This study highlighted the significant differences in the intestinal microbiota and predictive functions of GD with GO, thereby providing new insights into the role of the gut bacteria that might contribute to the development of GO in GD patients.
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- 2020
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35. Sedimentary environment and geological significance of the Upper Devonian Wutong Formation in Northern Yangtze Plateau, China
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J. Gao, H. Y. Liu, and Dawei Lv
- Subjects
Sedimentary depositional environment ,Sea level change ,Paleontology ,geography ,Plateau ,geography.geographical_feature_category ,Earth and Planetary Sciences (miscellaneous) ,General Earth and Planetary Sciences ,China ,Devonian ,Geology - Abstract
There is an ongoing debate about the evolution and geological significance of sediments deposited during the Upper Devonian period in the Wutong Formation on the northern margin of Yangtze Plate. A...
- Published
- 2020
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36. Oxidovanadium(V) and Dioxidomolybdenum(VI) Complexes of N’-(3,5-Dichloro-2-hydroxybenzylidene)-4- fluorobenzohydrazide: Synthesis, Characterization, Crystal Structures and Catalytic Property
- Author
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Xiao-Ling Zou, H. Y. Liu, Luo-Ju Yang, Ya-Fang Ye, and Yi-Shu Yin
- Subjects
chemistry.chemical_classification ,crystal structure ,molybdenum complex ,catalytic property ,Chemistry ,Hydrazone ,Nuclear magnetic resonance spectroscopy ,Crystal structure ,Medicinal chemistry ,vanadium complex ,Catalysis ,lcsh:Chemistry ,Metal ,hydrazone ,lcsh:QD1-999 ,Octahedron ,Catalytic oxidation ,visual_art ,visual_art.visual_art_medium ,General Earth and Planetary Sciences ,Single crystal ,General Environmental Science - Abstract
N' -(3,5-Dichloro-2-hydroxybenzylidene)-4-fluorobenzohydrazide (H 2 L) was used to prepare oxidovanadium(V) complex [VOL(OEt)(MeOH)] ( 1 ) and dioxidomolybdenum(VI) complex [MoO 2 L(OH 2 )]·[MoO 2 L(EtOH)] ( 2 ). The complexes were characterized by IR, UV-Vis, NMR spectroscopy, and single crystal X-ray diffraction. X-ray analysis indicates that the complexes are mononuclear species with the metal atoms in octahedral coordination. The complexes were studied for catalytic oxidation property on some olefins with tert -butyl hydroperoxide as oxidant.
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- 2020
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37. [Association of
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T, Zhang, Q M, Rao, Y Y, He, J T, Cai, H Y, Liu, and Y L, Lin
- Subjects
Adult ,Male ,Depressive Disorder, Major ,ATP Binding Cassette Transporter, Subfamily B ,NAV1.2 Voltage-Gated Sodium Channel ,Adolescent ,Genotype ,Arylamine N-Acetyltransferase ,Polymorphism, Single Nucleotide ,Clopidogrel ,Cytochrome P-450 CYP2C19 ,Young Adult ,Gene Frequency ,Case-Control Studies ,Humans ,Female ,Genetic Predisposition to Disease ,Alleles - Published
- 2022
38. Local anesthesia with sedation and general anesthesia for the treatment of chronic subdural hematoma: a systematic review and meta-analysis
- Author
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H-Y, Liu, L-L, Yang, X-Y, Dai, and Z-P, Li
- Subjects
Postoperative Complications ,Treatment Outcome ,Hematoma, Subdural, Chronic ,Drainage ,Humans ,Anesthesia, General ,Anesthesia, Local - Abstract
Drilling and drainage is the main treatment for chronic subdural hematoma (cSDH). However, anesthesia methods also have an important effect on patients' postoperative outcomes. The clinical effect of drainage of cSDH under local anesthesia with sedation (LAS) and general anesthesia (GA) was systematically evaluated.A literature study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for studies that compare LAS and GA for cSDH. The following treatment outcomes were compared between LAS and GA: total duration of surgery, postoperative complications, mortality, recurrence rate, and hospital length of stay (LOS).Four papers (n = 391, LAS: 196, GA: 195) met the inclusion criteria. Although there was no statistically significant difference between the two groups in mortality (OR: 0.47, 95% CI: 0.06-3.84, p = 0.48; p = 0.2, I2 = 39%), recurrence rate (OR: 0.82, 95% CI: 0.33-2.04, p = 0.66; p = 0.69, I2 = 0%), LOS (ratio of means: 0.86, 95% CI: 0.71-1.05, p = 0.14; p = 0.02, I2 = 75%). The total duration of surgery (MD: -26.71 min, 95% CI: -37.29 to -16.13, p0.00001; p = 0.65, I2 = 0%) was significantly shorter and the number of postoperative complications was significantly lower in the LAS group compared with the GA group (OR: 0.25, 95% CI: 0.13-0.50, p0.0001; p= 0.62, I2 = 0%).A systematic review and meta-analysis of the existing literature showed that LAS reduces the total duration of surgery and postoperative complications compared to GA. No significant difference in mortality, recurrence rate, and LOS was observed between the two groups.
- Published
- 2022
39. Is sudden deafness in non-diabetic patients affected by their glycosylated hemoglobin levels?
- Author
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G-H, Zeng, Y-J, Su, H-Y, Liu, and D-H, Lu
- Subjects
Glycated Hemoglobin ,Hearing Loss, Sensorineural ,Quality of Life ,Humans ,Hearing Loss, Sudden ,Glucocorticoids ,Retrospective Studies - Abstract
Though the incidence of sudden sensorineural hearing loss (SSNHL) is relatively low, the disorder has a major impact on the quality of life of patients. Identifying biological markers for the disease will be useful, especially in resource-scarce areas. Our study aims to evaluate the correlation between the degree of hearing impairment and glycosylated hemoglobin (HbA1c) in patients with SSNHL.One hundred and thirty-eight patients with SSNHL and no history of diabetes were included in this study. The intravenous HbA1c content before treatment was correlated with the pure tone audiogram (PTA) average as per the criteria for SSNHL. Spearman correlation and the Receiver Operating Characteristic (ROC) curve were used to determine the HbA1c levels of the study participants. The critical value of HbA1c and its diagnostic implications for assessing the degree of hearing impairment in patients with SSNHL were noted.There was a significant positive correlation between HbA1c and PTA in patients with SSNHL (p0.05). In addition, the best HbA1c cutoff value for screening and referring an individual for a detailed audiometric evaluation of hearing impairment was 5.550%, as indicated by the ROC curve.The level of HbA1c in the circulation may affect the onset, duration, and progression of SSNHL. The same parameter may be used as a diagnostic and prognostic indicator for this condition.
- Published
- 2022
40. [Clinical features of 19 cases of lower respiratory papillomatosis]
- Author
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H L, Li, H Y, Liu, M L, Yang, and J M, Deng
- Subjects
Adult ,Male ,Human papillomavirus 16 ,Human papillomavirus 18 ,Child, Preschool ,Papillomavirus Infections ,Humans ,Female ,Middle Aged ,Neoplasm Recurrence, Local ,Child ,Respiratory Tract Infections ,Retrospective Studies - Published
- 2022
41. Possible link between Holocene East Asian monsoon and solar activity obtained from the EMD method
- Author
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H. Y. Liu, Z. S. Lin, X. Z. Qi, Y. X. Li, M. T. Yu, H. Yang, and J. Shen
- Subjects
Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
It is thought that East Asian monsoon (EAM) is linked and sensitive to solar activity. In this paper, we have decomposed the Dongge cave speleothem δ18O record (proxy for EAM), and Δ14C and 10Be (proxies for solar activity) time series into variations at different time scales with the empirical mode decomposition (EMD) method to reveal the possible link between the EAM variability and solar activity. There are some common cycles in the EAM and solar variability from centennial to millennial scales, indicating a possible link between EAM and solar activity at these time scales. The correlation between EAM and solar activity is much higher at millennial scales than at centennial scales, which means direct responses to the solar variation are more likely at time scales longer than a few hundred years. At ~30, 60 and 600 yr time scales, the variation in EAM is amplified by the solar amplitude modulation at ~100, 200 and 2200 yr time scales.
- Published
- 2012
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42. Metal-Free Xanthene-Bridged Bis-Corrole: Synthesis and Efficient Electrocatalytic Hydrogen Evolution
- Author
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Zh.-Y. Liu, X.-M. Cheng, X.-Y. Xiao, C.-K. Chang, H.-Y. Liu, J.-J. Fang, and F. Yam
- Subjects
Xanthene ,Electrolysis ,General Chemistry ,Overpotential ,Combinatorial chemistry ,law.invention ,Catalysis ,chemistry.chemical_compound ,Acetic acid ,chemistry ,Metal free ,law ,Hydrogen evolution ,Corrole - Abstract
A new metal-free xanthene-bridged bis-corrole had been synthesized and used as a catalyst for electrocatalytic hydrogen evolution reaction for the first time. This bis-corrole demonstrated high catalytic efficiency in DMF and acetonitrile-aqueous solution upon using acetic acid as the protons source. The turnover frequency (TOF) could reach 627.75 h–1 in DMF at the overpotential of 924 mV and 581.42 h–1 in neutral buffer acetonitrile-aqueous solution at the overpotential of 828 mV. The prepared bis-corrole also exhibted good stability in the electrolysis. This study highlights that linking one corrole macrocycle to another can lead to the metal-free bis-corrole as a stable HER catalyst.
- Published
- 2021
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43. Abnormal keratin expression pattern in prurigo nodularis epidermis
- Author
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L. L. Yang, B. Jiang, S. H. Chen, H. Y. Liu, T. T. Chen, L. H. Huang, M. Yang, J. Ding, J. J. He, J. J. Li, and B. Yu
- Subjects
General Medicine - Abstract
Prurigo nodularis (PN) is a highly pruritic, chronic dermatosis and difficult to treat. PN lesions are characterized by existence of many hyperkeratotic, erosive papules and nodules. However, the pathogenesis of PN still remains unelucidated.To clarify the keratin role in the epidermis hyperproliferation, the keratin expression pattern in the PN lesional skin.In this study, we enrolled 24 patients with PN and 9 healthy control volunteers. K1/K10, K5/K14, K6/K16/K17 expression pattern were investigated by using immunohistochemical staining.The lesional skin consists of the thickened spinous layers, in which active cell division was found. K5/K14 were upregulated in PN lesional epidermis, the staining signal localized in the basal layer and lower suprabasal layers. Hyperproliferation-associated K6 was found in all layers of epidermal lesional skin, especially in the spinous layers. In contrast, K16 was only detected in the basal and lower suprabasal layers, K17 was observed in the basal and spinous layers. Terminal differential keratins K1/K10 were upregulated, detected in the pan-epidermis, but spared in the basal and low suprabasal layers.The keratinocytes enter an alternative differentiation pathway, which are responsible for the activated keratinocyte phenotype, abnormal keratins expression potentially contributes to the keratinocytes proliferation, subsequently lead to increased lesional skin epidermis thickness, hyperkeratiosis and alteration of skin barrier properties.
- Published
- 2021
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44. [Observation and experiment: a causal perspective]
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Y J, Zheng, H Y, Liu, B, Yu, A Q, Hu, Y, Dong, and Y, Guo
- Subjects
Causality ,Humans - Abstract
Observation and experiment and their related connotations and concepts remain vague, which affects the correct understanding of research design and the judgment of the validity of causal inference. This article borrows the concept of phase transition in physics, combines causal thinking and causal diagrams, firstly establishes the relationships among the attribute, state, event, and phenomenon, and then identifies two ways with the opposite causal structures to acquire phenomena-human observations and human manipulated experiments. In causal inference, the ways mentioned above, intervention and assignment of exposure are affected by their own causal mechanisms. Finally, intervention is a causal concept, a core link among known phenomena, unknown phenomena available for measurement, and natural causality. Based on this, the two strategies in classifying research design are analyzed, and intervention method and non-intervention method are proposed, as is comprehensive and concise. Observations and experiments provide the basis for all scientific knowledge and should be viewed as concepts with a unified connotation. The accurate classification of research designs based on the law of causality and measurement process may be one of the best options worthy of in-depth study.观察和实验及其设计、相关的概念和内涵仍然模糊,影响着研究设计的正确认识及因果推断有效性的判断。本文借用物理学的相变概念,结合因果思维与因果图,首先建立了事物的属性及其状态、事件与现象之间的关系;接着识别了两种现象获取方式——人为观察和人为实验之间相反的因果结构,及其与暴露的干预、分配在因果推断研究中受各自的因果机制影响;最后,识别了干预系因果概念,是自然因果律基础上联系已知的现象和/或需经测量而获得的现象之间的核心纽带;基于此分析了研究设计二分类的策略,以干预法和非干预法的分类更为清晰。观察和实验提供了所有科学知识的基础,应是内涵统一的概念。基于因果律及其测量过程可能是实现研究设计精准分类的最佳选项之一,值得深入研究。.
- Published
- 2021
45. [Hesitancy of parents towards vaccines in national immunization program in three regions in China: a cross-sectional study]
- Author
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T S, Zhao, H Y, Liu, H, Zheng, B F, Han, B, Liu, J, Liu, C Y, Zhao, X J, Li, S B, Yang, J, Du, N H, Huang, Q B, Lu, Y Q, Liu, and F Q, Cui
- Subjects
Parents ,China ,Health Knowledge, Attitudes, Practice ,Vaccines ,Cross-Sectional Studies ,Immunization Programs ,Vaccination ,Humans ,Child ,Diphtheria-Tetanus-Pertussis Vaccine - Published
- 2021
46. [Development and outlook on human challenge trial of vaccine]
- Author
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B F, Han, N H, Huang, L Y, Chen, T S, Zhao, H Y, Liu, S H, Zhang, Y, Wang, H, Zheng, B, Liu, C, Wang, Y Q, Liu, Q B, Lu, and F Q, Cui
- Subjects
Vaccines ,COVID-19 Vaccines ,SARS-CoV-2 ,COVID-19 ,Humans ,Pandemics - Abstract
Human challenge trial (HCT) is a test in which human volunteers are intentionally infected with pathogens in order to evaluate the efficacy of candidate preventive or therapeutic drugs. During the COVID-19 pandemic, the HCT of vaccines has aroused people's attention due to its significant advantages over clinical trial. This paper introduces the concept, development and application of HCT, the advantages and limitations of HCT for vaccine evaluation, and the consideration of future HCT of COVID-19 vaccine in China.人体挑战试验是指让人类志愿者有意感染病原体的试验,作为测试候选预防或治疗药物效果的方法。在新型冠状病毒肺炎(COVID-19)大流行期间,疫苗人体挑战试验因其较临床试验显著的优势而引起人们的关注。本文介绍了人体挑战试验的概念、发展、应用,人体挑战试验进行疫苗评估的优势和局限性,以及在中国未来开展新型冠状病毒疫苗人体挑战试验的考虑。.
- Published
- 2021
47. [Review on immunogenicity, safety and social value of combined vaccines for children used both at home and abroad]
- Author
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H Y, Liu, X, Wei, T S, Zhao, B F, Han, B, Liu, L, Yang, and F Q, Cui
- Subjects
Poliovirus Vaccine, Inactivated ,Social Values ,Vaccination ,Humans ,Infant ,Vaccines, Combined ,Child ,Diphtheria-Tetanus-acellular Pertussis Vaccines ,Measles-Mumps-Rubella Vaccine - Abstract
Combined vaccines contain two or more antigens. Research suggested that combined vaccines could prevent multi diseases and reduce the frequency of vaccination. This article focus on combined vaccines for children used both at home and abroad, such as diphtheria-pertussis-tetanus vaccine (DTaP), measles-rubella-mumps vaccine (MMR),联合疫苗含有两种或多种抗原,研究认为接种联合疫苗后能预防多种疾病,同时可减少接种次数。本文对国内外儿童用联合疫苗,如无细胞百白破疫苗(DTaP)、麻疹-风疹-腮腺炎疫苗(MMR)等免疫原性和安全性进行综述,并从儿童家长、预防接种工作者和卫生服务方面进行社会价值探究,为我国推动联合疫苗研发和使用提供决策证据。研究发现,联合疫苗对儿童、家长、预防接种工作者和卫生服务方面均产生较好的收益,能够保证其良好的免疫原性和安全性,增强家长的接种便利和经济性,提高预防接种工作者的工作效率,同时能弥补新发疫情对免疫服务造成的影响,提高接种覆盖率和及时率,增加社会收益。目前我国联合疫苗的推广受到技术瓶颈多,人群接种认知水平低等限制。建议加强联合疫苗安全性、有效性和卫生经济学等方面研究,科学评估联合疫苗的价值;增强公众对联合疫苗的认知和信任度;促进多联多价疫苗研发应用;政府应完善法规协助联合疫苗发展。.
- Published
- 2021
48. First Wide Field-of-view X-Ray Observations by a Lobster-eye Focusing Telescope in Orbit
- Author
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C. Zhang, Z. X. Ling, X. J. Sun, S. L. Sun, Y. Liu, Z. D. Li, Y. L. Xue, Y. F. Chen, Y. F. Dai, Z. Q. Jia, H. Y. Liu, X. F. Zhang, Y. H. Zhang, S. N. Zhang, F. S. Chen, Z. W. Cheng, W. Fu, Y. X. Han, H. Li, J. F. Li, Y. Li, P. R. Liu, X. H. Ma, Y. J. Tang, C. B. Wang, R. J. Xie, A. L. Yan, Q. Zhang, B. W. Jiang, G. Jin, L. H. Li, X. B. Qiu, D. T. Su, J. N. Sun, Z. Xu, S. K. Zhang, Z. Zhang, N. Zhang, X. Z. Bi, Z. M. Cai, J. W. He, H. Q. Liu, X. C. Zhu, H. Q. Cheng, C. Z. Cui, D. W. Fan, H. B. Hu, M. H. Huang, C. C. Jin, D. Y. Li, H. W. Pan, W. X. Wang, Y. F. Xu, X. Yang, B. Zhang, M. Zhang, W. D. Zhang, D. H. Zhao, M. Bai, Z. Ji, Y. R. Liu, F. L. Ma, J. Su, J. Z. Tong, Y. S. Wang, Z. J. Zhao, C. Feldman, P. O’Brien, J. P. Osborne, R. Willingale, V. Burwitz, G. Hartner, A. Langmeier, T. Müller, S. Rukdee, T. Schmidt, E. Kuulkers, and W. Yuan
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Space and Planetary Science ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) - Abstract
As a novel X-ray focusing technology, lobster eye micro-pore optics (MPO) feature both a wide observing field of view and true imaging capability, promising sky monitoring with significantly improved sensitivity and spatial resolution in soft X-rays. Since first proposed by Angel (1979), the optics have been extensively studied, developed and trialed over the past decades. In this Letter, we report on the first-light results from a flight experiment of the Lobster Eye Imager for Astronomy ($LEIA$), a pathfinder of the wide-field X-ray telescope of the Einstein Probe mission. The piggyback imager, launched in July 2022, has a mostly un-vignetted field of view of $18.6^\circ \times 18.6^\circ $. Its spatial resolution is in the range of 4$-$7 arcmin in FWHM and the focal spot effective area is 2$-$3 cm$^2$, both showing only mild fluctuations across the field of view. We present images of the Galactic center region, Sco X-1 and the diffuse Cygnus Loop nebular taken in snapshot observations over 0.5$-$4 keV. These are truly wide-field X-ray images of celestial bodies observed, for the first time, by a focusing imaging telescope. Initial analyses of the in-flight data show excellent agreement between the observed images and the on-ground calibration and simulations. The instrument and its characterization are briefly described, as well as the flight experiment. The results provide a solid basis for the development of the present and proposed wide-field X-ray missions using lobster eye MPO., Comment: 11 pages, 4 figures. Accepted for publication in Astrophysical Journal Letter
- Published
- 2022
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49. Dulwich OnView: an art museum-based virtual community generated by the local community.
- Author
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Ingrid Beazley, Jonathan P. Bowen, Alison H. Y. Liu, and Sarah McDaid
- Published
- 2010
50. [Clinicopathological features and prognosis of primary mediastinal large B-cell lymphoma: a series of sixty cases]
- Author
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H Y, Liu, R Q, Zhong, K P, Zhang, T N, Zhu, and D R, Zhong
- Subjects
Adult ,Male ,MicroRNAs ,Young Adult ,Adolescent ,Humans ,Female ,Lymphoma, Large B-Cell, Diffuse ,Middle Aged ,Prognosis ,Mediastinal Neoplasms ,Retrospective Studies - Published
- 2021
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