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Floods are consistently identified as the most serious global natural hazard, causing devastating loss of life and economic damage that runs into multiple billions of US dollars each year. At the coastline, many flood disasters are in fact compound flood events, with two or more flood drivers occurring concurrently or in quick succession. In coastal regions the combined effect of fluvial (river) and coastal (storm tides – storm surges and high astronomical tides) floods has a greater impact than if each occurred separately. Deltas in south-east Asia are particularly exposed to coastal compound floods as they are low-lying, densely populated regions subject to the intense rainfall storm surges frequently associated with tropical cyclone (TC) activity. For our study we used a sophisticated 1D river model, combined with 2D storm tide levels, to analyse past–present and future compound flood hazard and exposure for the Mekong River delta, one of the most flood-vulnerable deltas in the world. We found that with compound flooding, a greater area of the delta will be inundated, and some parts will flood to greater flood depth. Central areas around An Giang and the Dong Thap provinces are particularly impacted in our plausible scenario, where a TC makes landfall near the mouth of one Mekong River distributary. In the future delta, the impact of compound flooding is potentially more significant, as the same compound flood scenario inundates a greater area relative to the present case and to greater depth in many locations, and floods last longer. Compound flooding therefore has clear implications for flood managers of the future delta, who will need to ensure that existing and future flood defences are to the right standard and in the right locations to offer effective protection against this future risk.

Abstract Background The role of diet in breast cancer prevention is controversial and limited in low-middle-income countries (LMICs). This study aimed to investigate the association between different dietary factors and breast cancer risk in Vietnamese women. Methods Three hundred seventy newly histologically confirmed breast cancer cases and 370 controls matched by 5-year age from September 2019 to March 2020 in Ho Chi Minh City were recorded dietary intake using a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were evaluated using conditional logistic regression and adjusted with potential confounders. Results Compared to the lowest quartile of intake, we found that the highest intake of vegetables, fruit, soybean products, coffee, and egg significantly decreased breast cancer risk, including dark green vegetables (OR 0.46, 95% CI 0.27-0.78, ptrend=0.022), legumes (OR 0.19, 95% CI 0.08-0.44, ptrend

The last decade has seen the development and application of data-driven methods taking off in nuclear engineering research, aiming to improve the safety and reliability of nuclear power. This work focuses on developing a reinforcement learning-based control sequence optimization framework for advanced nuclear systems, which not only aims to enhance flexible operations, promoting the economics of advanced nuclear technology, but also prioritizing safety during normal operation. At its core, the framework allows the sequence of operational actions to be learned and optimized by an agent to facilitate smooth transitions between the modes of operations (i.e., load-following), while ensuring that all safety significant system parameters remain within their respective limits. To generate dynamic system responses, facilitate control strategy development, and demonstrate the effectiveness of the framework, a simulation environment of a pebble-bed high-temperature gas-cooled reactor was utilized. The soft actor-critic algorithm was adopted to train a reinforcement learning agent, which can generate control sequences to maneuver plant power output in the range between 100% and 50% of the nameplate power through sufficient training. It was shown in the performance validation that the agent successfully generated control actions that maintained electrical output within a tight tolerance of 0.5% from the demand while satisfying all safety constraints. During the mode transition, the agent can maintain the reactor outlet temperature within ±1.5 °C and steam pressure within 0.1 MPa of their setpoints, respectively, by dynamically adjusting control rod positions, control valve openings, and pump speeds. The results demonstrate the effectiveness of the optimization framework and the feasibility of reinforcement learning in designing control strategies for advanced reactor systems.

Abstract Background and aim Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in socio-demographically diverse participants from the ECHO PATHWAYS multi-cohort consortium. Methods We included 1,081 birth parent–child dyads across five U.S. cities. Maternal urinary mono-hydroxylated PAH metabolite concentrations (OH-PAH) were measured during mid-pregnancy. Asthma at age 8–9 years and wheezing trajectory across childhood were characterized by caregiver reported asthma diagnosis and asthma/wheeze symptoms. We used logistic and multinomial regression to estimate odds ratios of asthma and childhood wheezing trajectories associated with five individual OH-PAHs, adjusting for urine specific gravity, various maternal and child characteristics, study site, prenatal and postnatal smoke exposure, and birth year and season in single metabolite and mutually adjusted models. We used multiplicative interaction terms to evaluate effect modification by child sex and explored OH-PAH mixture effects through Weighted Quantile Sum regression. Results The prevalence of asthma in the study population was 10%. We found limited evidence of adverse associations between pregnancy OH-PAH concentrations and asthma or wheezing trajectories. We observed adverse associations between 1/9-hydroxyphenanthrene and asthma and persistent wheeze among girls, and evidence of inverse associations with asthma for 1-hydroxynathpthalene, which was stronger among boys, though tests for effect modification by child sex were not statistically significant. Conclusions In a large, multi-site cohort, we did not find strong evidence of an association between prenatal exposure to PAHs and child asthma at age 8–9 years, though some adverse associations were observed among girls.

Coastal floods, driven by extreme sea levels, are one of the most dangerous natural hazards. The people at highest risk are those living in low-lying coastal areas exposed to tropical-cyclone-forced storm surges. Here we apply a novel modelling framework to estimate past and/or present and future storm-surge-level and extreme-sea-level probabilities along the coastlines of southern China, Vietnam, Cambodia, Thailand, and Malaysia. A regional hydrodynamic model is configured to simulate 10 000 years of synthetic tropical cyclone activity, representative of a past/present (1980–2017) and high-emission-scenario future (2015–2050) period. Results show that extreme storm surges, and therefore total water levels, will increase substantially in the coming decades, driven by an increase in the frequency of intense tropical cyclones. Storm surges along the southern Chinese and northern and southern Vietnamese coastlines increase by up to 1 m, significantly larger than expected changes in mean sea-level rise over the same period. The length of coastline that is presently exposed to storm surge levels of 2.5 m or greater will more than double by 2050. Sections of Cambodian, Thai, and Malaysian coastlines are projected to experience storm surges (at higher return periods) in the future, not previously seen, due to a southward shift in tropical cyclone tracks. Given these findings, coastal flood management and adaptation in these areas should be reviewed for their resilience against future extreme sea levels.

BackgroundAsthma is a leading cause of childhood morbidity in the U.S. and a significant public health concern. The prenatal period is a critical window during which environmental influences, including maternal occupational exposures, can shape child respiratory health. Cleaning chemicals are commonly encountered in occupational settings, yet few studies have examined the potential link between prenatal occupational exposures to cleaning chemicals and risk of childhood wheeze and asthma.MethodsWe evaluated the potential influence of maternal occupational exposure to cleaning chemicals during pregnancy on pediatric asthma and wheeze at child age 4–6 years in 453 mother-child pairs from two longitudinal pregnancy cohorts, TIDES and GAPPS, part of the ECHO prenatal and early childhood pathways to health (ECHO-PATHWAYS) consortium. Maternal occupational exposure to cleaning chemicals was defined based on reported occupation and frequency of occupational use of chemicals during pregnancy. Child current wheeze and asthma outcomes were defined by parental responses to a widely-used, standardized respiratory outcomes questionnaire administered at child age 4–6 years. Multivariable Poisson regression with robust standard errors was used to estimate relative risk (RR) of asthma in models adjusted for confounding. Effect modification by child sex was assessed using product interaction terms.ResultsOverall, 116 mothers (25.6%) reported occupational exposure to cleaning chemicals during pregnancy, 11.7% of children had current wheeze, and 10.2% had current asthma. We did not identify associations between prenatal exposure to cleaning chemicals and current wheeze [RRadjusted 1.03, 95% confidence interval (CI): 0.56, 1.90] or current asthma (RRadjusted 0.89, CI: 0.46, 1.74) in the overall sample. Analyses of effect modification suggested an adverse association among females for current wheeze (RR 1.82, CI: 0.76, 4.37), compared to males (RR 0.68, CI: 0.29, 1.58), though the interaction p-value was >0.05.ConclusionWe did not observe evidence of associations between maternal prenatal occupational exposure to cleaning chemicals and childhood wheeze or asthma in the multi-site ECHO-PATHWAYS consortium. We leveraged longitudinal U.S. pregnancy cohorts with rich data characterization to expand on limited and mixed literature. Ongoing research is needed to more precisely characterize maternal occupational chemical exposures and impacts on child health in larger studies.