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Background: Germline BRCA1/2 mutation status is currently used as predictive biomarker for response to Poly-(ADP-Ribose)-Polymerase (PARP) inhibitors in breast cancer (BC) patients. However, non-germline BRCA1/2 mutated tumors and homologous recombination repair deficient (HRD) tumors with unknown etiology are probably also PARP inhibitor-sensitive. Various HRD biomarkers have been proposed and their clinical validity and utility are under investigation. We recently described the functional REpair CAPacity (RECAP) test as a real-time method to select HRD tumors based on their inability to form RAD51 foci. Here, we investigated whether this functional test defines a similar group of HRD tumors as DNA-based tests for primary and metastatic BCs. Materials and Methods: A cohort (n=71; 52 primary and 19 metastatic BCs) enriched for HRD tumors was selected based on the RECAP test, consisting of 26 RECAP-HRD (37%), 9 RECAP-HR intermediate (HRi; 13%) and 36 RECAP-HR proficient (HRP; 51%) tumors. Whole genome sequencing (WGS) was carried out on matched germline and tumor DNA samples for 38 primary BCs and the 19 metastatic lesions, for which material was available. Three samples were excluded due to a low purity score ( Results: The RECAP test identified all bi-allelic BRCA deficient samples (n=15) in this cohort as HRD/HRi. Within the remaining non-BRCA RECAP-HRD/HRi samples, there were no pathogenic mutations in other relevant genes that could explain the HRD status of these tumors. In the RECAP-HR proficient tumors no bi-allelic BRCA1/2 deficiencies were identified. The RECAP status partially correlated with the DNA-based HRD test outcomes using the HRDetect, CHORD and BRCA1/2-like classifier algorithms (70% concordance for RECAP-CHORD and RECAP-BRCA1/2-like classifier, and 66% for CHORD-BRCA1/2-like classifier). However, RECAP identified additional samples unable to form RAD51 foci. The discordance among the tests were evenly distributed among the primary and metastatic BCs. Conclusions: The difference between RECAP and other HRD tests in BC patients is relatively large (30-34% discordance), implying that RECAP may be identifying deficiencies in other components of DNA repair which could also result in PARP inhibitor sensitivity. Therefore, direct comparison of these HRD tests in clinical trials will be required to evaluate the optimal predictive test for clinical decision making. Citation Format: Titia G. Meijer, Luan Nguyen, Arne van Hoeck, Marjolijn M. Ladan, Nicole S. Verkaik, Kirsten Ruigrok-Ritstier, Carolien H. van Deurzen, Harmen J. van de Werken, Esther H. Lips, Sabine C. Linn, Yasin Memari, Helen Davies, Serena Nik-Zainal, Roland Kanaar, John W. Martens, Edwin Cuppen, Agnes Jager, Dik C. van Gent. RECAP (REpair CAPacity) identifies a subset of breast cancers unable to form RAD51 foci which are undetected by DNA-based BRCAness tests [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 805.

We present an update of the Binoth Les Houches Accord (BLHA) to standardise the interface between Monte Carlo programs and codes providing one-loop matrix elements., Comment: 24 pages, 1 pdf figure

This Report summarizes the results of the activities in 2012 and the first half of 2013 of the LHC Higgs Cross Section Working Group. The main goal of the working group was to present the state of the art of Higgs Physics at the LHC, integrating all new results that have appeared in the last few years. This report follows the first working group report Handbook of LHC Higgs Cross Sections: 1. Inclusive Observables (CERN-2011-002) and the second working group report Handbook of LHC Higgs Cross Sections: 2. Differential Distributions (CERN-2012-002). After the discovery of a Higgs boson at the LHC in mid-2012 this report focuses on refined prediction of Standard Model (SM) Higgs phenomenology around the experimentally observed value of 125-126 GeV, refined predictions for heavy SM-like Higgs bosons as well as predictions in the Minimal Supersymmetric Standard Model and first steps to go beyond these models. The other main focus is on the extraction of the characteristics and properties of the newly discovered particle such as couplings to SM particles, spin and CP-quantum numbers etc.

We present the calculation of the NLO QCD corrections to the associated production of a Higgs boson and two jets, in the infinite top-mass limit. We discuss the technical details of the computation and we show the numerical impact of the radiative corrections on several observables at the LHC. The results are obtained by using a fully automated framework for fixed order NLO QCD calculations based on the interplay of the packages GoSam and Sherpa. The evaluation of the virtual corrections constitutes an application of the d-dimensional integrand-level reduction to theories with higher dimensional operators. We also present first results for the one-loop matrix elements of the partonic processes with a quark-pair in the final state, which enter the hadronic production of a Higgs boson together with three jets in the infinite top-mass approximation., 9 pages, 7 figures, references added, published in Phys.Lett.B

We report on the calculation of the cross section for Higgs boson production in association with three jets via gluon fusion, at next-to-leading-order (NLO) accuracy in QCD, in the infinite top-mass approximation. After including the complete NLO QCD corrections, we observe a strong reduction in the scale dependence of the result, and an increased steepness in the transverse momentum distributions of both the Higgs boson and the leading jets. The results are obtained with the combined use of GoSam, Sherpa, and the MadDipole-MadEvent framework.

We present the version 2.0 of the program package GoSam for the automated calculation of one-loop amplitudes. GoSam is devised to compute one-loop QCD and/or electroweak corrections to multi-particle processes within and beyond the Standard Model. The new code contains improvements in the generation and in the reduction of the amplitudes, performs better in computing time and numerical accuracy, and has an extended range of applicability. The extended version of the "Binoth-Les-Houches-Accord" interface to Monte Carlo programs is also implemented. We give a detailed description of installation and usage of the code, and illustrate the new features in dedicated examples., replaced by published version and reference added

We elaborate on GoSam, a code-writer for automated one-loop calculations. After recalling its main features, we present a selection of phenomenological results recently obtained, giving relevance at the evaluation of NLO QCD corrections to the production of a Higgs boson in association with jets and heavy quarks., Presented at RADCOR 2013, 22-27 September 2013, Lumley Castle Hotel, Durham, UK

We present applications of the program GoSam for the automated calculation of one-loop amplitudes. Results for NLO QCD corrections to beyond the Standard Model processes as well as Higgs plus up to three-jet production in gluon fusion are shown. We also discuss some new features of the program., 9 pages, 5 figures, Contribution to the conference ACAT 2013 (Advanced Computing and Analysis Techniques in physics), Beijing, China, May 2013

We present the calculation of the cross section for Higgs boson production in association with a top quark pair plus one jet, at next-to-leading-order accuracy in QCD. All mass dependence is retained without recurring to any approximation. After including the complete next-to-leading-order QCD corrections, we observe a strong reduction in the scale dependence of the result. We also show distributions for the invariant mass of the top quark pair, with and without the additional jet, and for the transverse momentum and the pseudorapidity of the Higgs boson. Results for the virtual contributions are obtained with a novel reduction approach based on integrand decomposition via the Laurent expansion, as implemented in the library, NINJA. Cross sections and differential distributions are obtained with an automated setup which combines the GOSAM and SHERPA frameworks.

Spectra of vanadium have been produced in a vacuum sliding spark, and their relative line intensities have been measured as parameters of the electrical circuit were varied. Intensity maxima of the spectral lines are interpreted as representing excitation energies and have been found to depend in a definitive manner on the power delivered to the source and on the duration of the discharge. The differential equation of the circuit is solved for the charge and energy transfer rates from the capacitor to the source, and two functions of the continuous circuit parameter [Formula: see text] are defined which greatly assist in interpreting the effect of the circuit parameters on the excitation in the source. A relationship was found between the excitation in the source and the electrical circuit parameters. By means of this relationship one may obtain a good estimate of the excitation gained in the spark source. It is shown that by exercising careful control over the circuit parameters it is possible to separate spectra of neighboring ionization stages through either total pulse or time-resolved observations.

The 1S0 level of the 5f2 configuration of U v has been found at 43 613.58 ± 0.1 cm−1. A parametric fit of the 13 levels of the 5f2 configuration gives an rms deviation of 9.8 cm−1 with F2 = 51 938 ± 39, F4 = 42 708 ± 100, F6 = 27 748 ± 68, α = 35.5 ± 0.4, β = −664 ± 25, γ = 744 ± 26, ζ = 1968 ± 2, P2 = 573 ± 66, P4 = 524 ± 144, and P6 = 1173 ± 321, all in inverse centimeters.

The spectrum of V v has been observed by using a vacuum sliding spark at 1000-A peak current. Fifty-nine lines in the region 480–8500 A have been observed and interpreted as transitions among 29 levels, 19 of which are new. The ionization energy is determined as 526 524 ± 5 cm−1. An isoelectronic comparison confirms the inversion of the 3p64f2F5/2, 7/2∘ levels as being caused by their interaction with those of the 2F∘ term in the 3p53d2 configuration.

The spectrum of Sc iii has been observed by using a vacuum sliding spark at 250-A peak current. Excellent separation of the Sc i, ii, and iii spectra was achieved by careful control of the excitation-circuit parameters. In all, 93 lines in the region 550–9400 A are listed, which give rise to 23 new levels. The ionization energy of Sc iii is revised to 199 677.37 ±0.1 cm−1, based on the ng series, and series formulas are presented which were used to predict some of the newly found levels to within 0.25 cm−1. An isoelectronic comparison of Sc iii with K i and Ca ii is made.