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After performing the morpho-kinematic analysis of the planetary nebula (PN) PC 22, we now present its nebular and stellar analysis. The plasma investigation relies on the novel use of a Monte Carlo analysis associated with the PYNEB code for the uncertainty propagation. The innermost region of the nebula shows electronic temperatures Te ≈ 10 800 K using [N II] and ≈13 000 K using [O III] and electronic densities ne ≈ 600 cm−3. We also used for the first time a machine learning algorithm to calculate ionization correction factors (ICFs) specifically adapted to PC 22. This has allowed us to have pioneer ICFs for (S+ + S++)/O++, Cl++/O++, and Ar3+ + Ar4+, as well as a possible new determination for the total abundance of neon. The study of the stellar spectrum revealed the presence of broad emission lines consistent with a Wolf–Rayet-type [WR] classification and more precisely a [WO1] subtype based on different qualitative and quantitative criteria. This classification is also coherent with the high stellar temperature derived from the reproduction of the ionization state of the gas with the Mexican Million Models data base (3MdB) and the best-fitting model obtained with the NLTE model atmosphere code PoWR. PC 22 is therefore a new addition to the [WO1]-subtype PNe. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society., LS acknowledges support from PAPIIT grant IN101819 (Mexico). VGL and CM acknowledge grants CONACYT/CB2015 – 254132 and UNAM/PAPIIT – IN101220. VMAGG acknowledges support from the Programa de Becas posdoctorales funded by Dirección General de Asuntos del Personal Académico of the Universidad Nacional Autónoma de México (DGAPA, UNAM). MAG acknowledges support of the grant PGC2018-102184-B-I00 of the Spanish Ministerio de Ciencias, Innovación y Universidades. Also, we want to thank the OAN-SPM staff and the CATT for time allocation. This study is based on observations made with the 2.1 m telescope of the Observatorio Astronómico Nacional at the Sierra de San Pedro Mártir (OAN-SPM), which is a national facility operated by the Instituto de Astronomía of the Universidad Nacional Autónoma de México. This research has made use of the NASA/IPAC Infrared Science Archive, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. We have also used archival observations made with the NASA/ESA Hubble Space Telescope, and obtained from the Hubble Legacy Archive, which is a collaboration between the Space Telescope Science Institute (STScI/NASA), the Space Telescope European Coordinating Facility (ST-ECF/ESA), and the Canadian Astronomy Data Centre (CADC/NRC/CSA). This paper has been edited using the Overleaf facility., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

M33 X-7 is the only known eclipsing black hole high mass X-ray binary. The system is reported to contain a very massive O supergiant donor and a massive black hole in a short orbit. The high X-ray luminosity and its location in the metal-poor galaxy M33 make it a unique laboratory for studying the winds of metal-poor donor stars with black hole companions and it helps us to understand the potential progenitors of black hole mergers. Using phase-resolved simultaneous HST- and XMM-Newton-observations, we traced the interaction of the stellar wind with the black hole. Our comprehensive spectroscopic investigation of the donor star (X-ray+UV+optical) yields new stellar and wind parameters for the system that differs significantly from previous estimates. In particular, the masses of the components are considerably reduced to 38 for the O-star donor and 11.4 for the black hole. The O giant is overfilling its Roche lobe and shows surface He enrichment. The donor shows a densely clumped wind with a mass-loss rate that matches theoretical predictions. We investigated the wind-driving contributions from different ions and the changes in the ionization structure due to X-ray illumination. Toward the black hole, the wind is strongly quenched due to strong X-ray illumination. For this system, the standard wind-fed accretion scenario alone cannot explain the observed X-ray luminosity, pointing toward an additional mass overflow, which is in line with our acceleration calculations. The X-ray photoionization creates an He II emission region emitting $10^{47}$ ph/s. We computed binary evolutionary tracks for the system using MESA. Currently, the system is transitioning toward an unstable mass transfer phase, resulting in a common envelope of the black hole and donor. Since the mass ratio is q~3.3 and the period is short, the system is unlikely to survive the common envelope, but will rather merge., Accepted for publication in Astronomy & Astrophysics

Massive stars are among the main cosmic engines driving the evolution of star-forming galaxies. Their powerful ionising radiation and stellar winds inject a large amount of energy in the interstellar medium. Furthermore, mass-loss ($\dot{M}$) through radiatively driven winds plays a key role in the evolution of massive stars. Even so, the wind mass-loss prescriptions used in stellar evolution models, population synthesis, and stellar feedback models often disagree with mass-loss rates empirically measured from the UV spectra of low metallicity massive stars. The most massive young star cluster in the low metallicity Small Magellanic Cloud galaxy is NGC346. This cluster contains more than half of all O stars discovered in this galaxy so far. A similar age, metallicity ($Z$), and extinction, the O stars in the NGC346 cluster are uniquely suited for a comparative study of stellar winds in O stars of different subtypes. We aim to use a sample of O stars within NGC346 to study stellar winds at low metallicity. We mapped the central 1" of NGC346 with the long-slit UV observations performed by the Space Telescope Imaging Spectrograph (STIS) on board of the {\em Hubble Space Telescope} and complemented these new datasets with archival observations. Multi-epoch observations allowed for the detection of wind variability. The UV dataset was supplemented by optical spectroscopy and photometry. The resulting spectra were analysed using a non-local thermal equilibrium model atmosphere code (PoWR) to determine wind parameters and ionising fluxes. The effective mapping technique allowed us to obtain a mosaic of almost the full extent of the cluster and resolve stars in its core. Among hundreds of extracted stellar spectra, 21 belong to O stars. Nine of them are classified as O stars for the first time. We analyse, in detail, the UV spectra of 19 O stars... (continued), Comment: 33 pages, 40 figures

We present the analysis of the optical variability of the early, nitrogen-rich Wolf-Rayet (WR) star WR7. The analysis of multi-sector Transiting Exoplanet Survey Satellite (TESS) light curves and high-resolution spectroscopic observations confirm multi-periodic variability that is modulated on time-scales of years. We detect a dominant period of $2.6433 \pm 0.0005$ d in the TESS sectors 33 and 34 light curves in addition to the previously reported high-frequency features from sector 7. We discuss the plausible mechanisms that may be responsible for such variability in WR7, including pulsations, binarity, co-rotating interacting regions (CIRs) and clumpy winds. Given the lack of strong evidence for the presence of a stellar or compact companion, we suggest that WR7 may pulsate in quasi-coherent modes in addition to wind variability likely caused by CIRs on top of stochastic low-frequency variability. WR7 is certainly a worthy target for future monitoring in both spectroscopy and photometry to sample both the short ($\lesssim 1$ d) and long ($\gtrsim 1000$ d) variability time scales., 9 pages, 5 Figures, 1 Table; Accepted to MNRAS

Massive stars at low metallicity are among the main feedback agents in the early Universe and in present-day star forming galaxies. When in binaries, these stars are potential progenitors of gravitational-wave events. Knowledge of stellar masses is a prerequisite to understanding evolution and feedback of low-metallicity massive stars. Using abundant spectroscopic and photometric measurements of an outstandingly bright eclipsing binary, we compare its dynamic, spectroscopic, and evolutionary mass estimates and develop a binary evolution scenario. We comprehensively studied the eclipsing binary system, AzV 476, in the Small Magellanic Cloud. The light curve and radial velocities were analyzed to obtain the orbital parameters. The photometric and spectroscopic data in the UV and optical were analyzed using the Potsdam Wolf-Rayet model atmospheres. The obtained results are interpreted using binary-evolution tracks. AzV 476 consists of an O4IV-III((f))p primary and an O9.5:Vn secondary. Both components have similar current masses (~20 M$_{\odot}$) obtained from both the orbital and spectroscopic analysis. The wind mass-loss rate of log($\dot{M}$/(M$_{\odot}$/yr))=-6.2 of the primary is a factor of ten higher than a recent empirical prescription for single O stars in the SMC. Only close-binary evolution with mass transfer can reproduce the current stellar and orbital parameters. The binary evolutionary model reveals that the primary has lost about half of its initial mass and is already core helium burning. Our comprehensive analysis of AzV 476 yields a consistent set of parameters and suggests previous case B mass transfer. The derived stellar masses agree within their uncertainties. The moderate masses of AzV 476 underline the scarcity of bright massive stars in the SMC. The core helium burning nature of the primary indicates that stripped stars might be hidden among OB-type populations., Comment: 18 pages + 5 pages appendix, 17 figures, 8 tables. Accepted for publication in A&A

We present a multiwavelength characterization of the planetary nebula (PN) NGC 6905 and its [Wolf–Rayet]-type ([WR]) central star (CSPN) HD 193949. Our Nordic Optical Telescope Alhambra Faint Object Spectrograph and Camera (ALFOSC) spectra and images unveil in unprecedented detail the high-ionization structure of NGC 6905. The high-quality spectra of HD 193949 allowed us to detect more than 20 WR features including the characteristic O-bump, blue bump, and red bump, which suggests a spectral type no later than a [WO2]-subtype. Moreover we detect the Ne VII and Ne VIII broad emission lines, rendering HD 193949 yet another CSPN with Teff ≲ 150 kK exhibiting such stellar emission lines. We studied the physical properties (Te and ne) and chemical abundances of different regions within NGC 6905 including its low-ionization clumps; abundances are found to be homogeneous. We used the PoWR stellar atmosphere code to model the spectrum of HD 193949, which is afterwards used in a photoionization model performed with CLOUDY that reproduces the nebular and dust properties for a total mass in the 0.31–0.47 M⊙ range and a mass of C-rich dust of ∼2 × 10−3 M⊙. Adopting a current stellar mass of 0.6 M⊙, our model suggests an initial mass ∼1 M⊙ for HD 193949, consistent with the observations. © 2021 The Author(s)., VMAGG acknowledges support from the Programa de Becas posdoctorales of the Dirección General de Asuntos del Personal Académico of the Universidad Nacional Autónoma de México (DGAPA, UNAM, Mexico). VMAGG and JAT acknowledge funding by DGAPA UNAM PAPIIT project IA100720. JAT also acknowledges support from the Marcos Moshinsky Fundation (Mexico). GR acknowledge support from Consejo Nacional de Ciencia y Tecnología (CONACYT) for student scholarship. MAG acknowledges support of the Spanish Ministerio de Ciencia, Innovación y Universidades grant PGC2018-102184-B-I00, cofunded by FEDER funds. LS acknowledges funding by DGAPA UNAM PAPIIT project IN-101819. GR-L acknowledges support from CONACYT grant 263373 and PRODEP (Mexico). This work is based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos in La Palma, Spain, of the Instituto de Astrofisica de Canarias. This work uses public data from the IR telescope Spitzer Space Telescope through the NASA/IPAC Infrared Science Archive, which is operated by the Jet Propulsion Laboratory at the California Institute of Technology, under contract with the National Aeronautics and Space Administration (NASA). WISE is a joint project of the University of California (Los Angeles, USA) and the JPL/Caltech. The Infrared Astronomical Satellite (IRAS) was a joint project of the US, UK, and the Netherlands. This research is based on observations with AKARI, a JAXA project with the participation of ESA. This work has make extensive use of the NASA’s Astrophysics Data System., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

High-mass X-ray binaries (HMXBs) are exceptional astrophysical laboratories that offer a rare glimpse into the physical processes that govern accretion on compact objects, massive-star winds, and stellar evolution. In a subset of the HMXBs, the compact objects accrete matter solely from winds of massive donor stars. These so-called wind-fed HMXBs are divided in persistent HMXBs and supergiant fast X-ray transients (SFXTs) according to their X-ray properties. While it has been suggested that this dichotomy depends on the characteristics of stellar winds, they have been poorly studied. With this investigation, we aim to remedy this situation by systematically analyzing donor stars of wind-fed HMXBs that are observable in the UV, concentrating on those with neutron star (NS) companions. We obtained Swift X-ray data, HST UV spectra, and additional optical spectra for all our targets. Our multi-wavelength approach allows us to provide stellar and wind parameters for six donor stars (four wind-fed systems and two OBe X-ray binaries). The wind properties are in line with the predictions of the line-driven wind theory. Three of the donor stars are in an advanced evolutionary stage, while for some of the stars, the abundance pattern indicates that processed material might have been accreted. When passing by the NS in its tight orbit, the donor star wind has not yet reached its terminal velocity but it is still significantly slower; its speed is comparable with the orbital velocity of the NS companion. There are no systematic differences between the two types of wind-fed HMXBs (persistent versus transients) with respect to the donor stars. For the SFXTs in our sample, the orbital eccentricity is decisive for their transient X-ray nature. Based on the orbital parameters and the further evolution of the donor stars, the investigated HMXBs will presumably form Thorne-\.Zytkow objects in the future., Comment: 44 pages, 13 figures, 15 tables; accepted for publication in A&A

Wolf-Rayet stars of the carbon sequence (WC stars) are an important cornerstone in the late evolution of massive stars before their core collapse. As core-helium burning, hydrogen-free objects with huge mass-loss, they are likely the last observable stage before collapse and thus promising progenitor candidates for type Ib/c supernovae. Their strong mass-loss furthermore provides challenges and constraints to the theory of radiatively driven winds. Thus, the determination of the WC star parameters is of major importance for several astrophysical fields. With Gaia DR2, for the first time parallaxes for a large sample of Galactic WC stars are available, removing major uncertainties inherent to earlier studies. In this work, we re-examine a previously studied sample of WC stars to derive key properties of the Galactic WC population. All quantities depending on the distance are updated, while the underlying spectral analyzes remain untouched. Contrasting earlier assumptions, our study yields that WC stars of the same subtype can significantly vary in absolute magnitude. With Gaia DR2, the picture of the Galactic WC population becomes more complex: We obtain luminosities ranging from log L/L-circle dot = 4.9-6.0 with one outlier (WR 119) having log L/L-circle dot = 4.7. This indicates that the WC stars are likely formed from a broader initial mass range than previously assumed. We obtain mass-loss rates ranging between log(M) over dot = -5.1 and -4.1, with (M) over dot proportional to L-0.68 and a linear scaling of the modified wind momentum with luminosity. We discuss the implications for stellar evolution, including unsolved issues regarding the need of envelope inflation to address the WR radius problem, and the open questions in regard to the connection of WR stars with Gamma-ray bursts. WC and WO stars are progenitors of massive black holes, collapsing either silently or in a supernova that most-likely has to be preceded by a WO stage.

Comprehensive spectral analyses of the Galactic Wolf-Rayet stars of the nitrogen sequence (i.e.\ the WN subclass) have been performed in a previous paper. However, the distances of these objects were poorly known. Distances have a direct impact on the "absolute" parameters, such as luminosities and mass-loss rates. The recent Gaia Data Release (DR2) of trigonometric parallaxes includes nearly all WN stars of our Galactic sample. In the present paper, we apply the new distances to the previously analyzed Galactic WN stars and rescale the results accordingly. On this basis, we present a revised catalog of 55 Galactic WN stars with their stellar and wind parameters. The correlations between mass-loss rate and luminosity show a large scatter, for the hydrogen-free WN stars as well as for those with detectable hydrogen. The slopes of the $\log L - \log \dot{M}$ correlations are shallower than found previously. The empirical Hertzsprung-Russell diagram (HRD) still shows the previously established dichotomy between the hydrogen-free early WN subtypes that are located on the hot side of the zero-age main sequence (ZAMS), and the late WN subtypes, which show hydrogen and reside mostly at cooler temperatures than the ZAMS (with few exceptions). However, with the new distances, the distribution of stellar luminosities became more continuous than obtained previously. The hydrogen-showing stars of late WN subtype are still found to be typically more luminous than the hydrogen-free early subtypes, but there is a range of luminosities where both subclasses overlap. The empirical HRD of the Galactic single WN stars is compared with recent evolutionary tracks. Neither these single-star evolutionary models nor binary scenarios can provide a fully satisfactory explanation for the parameters of these objects and their location in the HRD., Comment: 11 pages; accepted for publication in Astronomy & Astrophysics

The first directly detected gravitational waves (GW 150914) were emitted by two coalescing black holes (BHs) with masses of ~36Msun and ~29Msun. Several scenarios have been proposed to put this detection into an astrophysical context. The evolution of an isolated massive binary system is among commonly considered models. Various groups have performed detailed binary-evolution calculations that lead to BH merger events. However, the question remains open as to whether binary systems with the predicted properties really exist. The aim of this paper is to help observers to close this gap by providing spectral characteristics of massive binary BH progenitors during a phase where at least one of the companions is still non-degenerate. Stellar evolution models predict fundamental stellar parameters. Using these as input for our stellar atmosphere code (PoWR), we compute a set of models for selected evolutionary stages of massive merging BH progenitors at different metallicities. The synthetic spectra obtained from our atmosphere calculations reveal that progenitors of massive BH merger events start their lives as O2-3V stars that evolve to early-type blue supergiants before they undergo core-collapse during the Wolf-Rayet phase. When the primary has collapsed, the remaining system will appear as a wind-fed high-mass X-ray binary. We provide feedback parameters, broad band magnitudes, and spectral templates that should help to identify such binaries in the future. Comparisons of empirically determined mass-loss rates with those assumed by evolution calculations reveal significant differences. The consideration of the empirical mass-loss rates in evolution calculations will possibly entail a shift of the maximum in the predicted binary-BH merger rate to higher metallicities, that is, more candidates should be expected in our cosmic neighborhood than previously assumed., Comment: 64 pages, 30 figures, accepted for publication in Astronomy & Astrophysics, v2: typos corrected

Wolf-Rayet stars of the carbon sequence (WC stars) are an important cornerstone in the late evolution of massive stars before their core collapse. As core-helium burning, hydrogen-free objects with huge mass-loss, they are likely the last observable stage before collapse and thus promising progenitor candidates for type Ib/c supernovae. Their strong mass-loss furthermore provides challenges and constraints to the theory of radiatively driven winds. Thus, the determination of the WC star parameters is of major importance for several astrophysical fields. With Gaia DR2, for the first time parallaxes for a large sample of Galactic WC stars are available, removing major uncertainties inherent to earlier studies. In this work, we re-examine the sample from Sander et al. (2012) to derive key properties of the Galactic WC population. All quantities depending on the distance are updated, while the underlying spectral analyses remain untouched. Contrasting earlier assumptions, our study yields that WC stars of the same subtype can significantly vary in absolute magnitude. With Gaia DR2, the picture of the Galactic WC population becomes more complex: We obtain luminosities ranging from log L = 4.9 to 6.0 with one outlier having log L = 4.7. This indicates that the WC stars are likely formed from a broader initial mass range than previously assumed. We obtain mass-loss rates ranging between log Mdot = -5.1 and -4.1, with Mdot propto L^0.68 and a linear scaling of the modified wind momentum with luminosity. We discuss the implications for stellar evolution, including unsolved issues regarding the need of envelope inflation to address the WR radius problem, and the open questions in regard to the connection of WR stars with Gamma-ray bursts. WC and WO stars are progenitors of massive black holes, collapsing either silently or in a supernova that most-likely has to be preceded by a WO stage., Comment: 19 pages, 13 figures, 6 tables; A&A, v2: version in press

The on-site characterization of complex fluids is important for a number of academic and industrial applications. Consequently, a need exists to develop portable rheometers that can provide in the field diagnostics and serve as tools for rapid quality assurance. With the advancement of smartphone technology and the widespread global ownership of smart devices, mobile applications are attractive as platforms for rheological characterization. The present work investigates the use of a smartphone device for the extensional characterization of a series of Boger fluids composed of glycerol/water and poly(ethylene oxide), taking advantage of the increasing high-speed video capabilities (currently up to 240 Hz capture rate at 720p) of smartphone cameras. We report a noticeable difference in the characterization of samples with slight variations in polymer concentration and discuss current device limitations. Potential benefits of a handheld extensional rheometer include its use as a point-of-care diagnostic tool, especially in developing communities, as well as a simple and inexpensive tool for assessing product quality in industry.

Wolf-Rayet (WR) stars are the most advanced stage in the evolution of the most massive stars. The strong feedback provided by these objects and their subsequent supernova (SN) explosions are decisive for a variety of astrophysical topics such as the cosmic matter cycle. Consequently, understanding the properties of WR stars and their evolution is indispensable. A crucial but still not well known quantity determining the evolution of WR stars is their mass-loss rate. Since the mass loss is predicted to increase with metallicity, the feedback provided by these objects and their spectral appearance are expected to be a function of the metal content of their host galaxy. This has severe implications for the role of massive stars in general and the exploration of low metallicity environments in particular. Hitherto, the metallicity dependence of WR star winds was not well studied. In this contribution, we review the results from our comprehensive spectral analyses of WR stars in environments of different metallicities, ranging from slightly super-solar to SMC-like metallicities. Based on these studies, we derived empirical relations for the dependence of the WN mass-loss rates on the metallicity and iron abundance, respectively., Comment: 5 pages, 4 figures, to be published in the Proceedings of the IAU Symposium No. 329 "The lives and death-throes of massive stars"

Stars which start their lives with spectral types O and early-B are the progenitors of core-collapse supernovae, long gamma-ray bursts, neutron stars, and black holes. These massive stars are the primary sources of stellar feedback in star-forming galaxies. At low metallicities, the properties of massive stars and their evolution are not yet fully explored. Here we report a spectroscopic study of 320 OB stars in the Small Magellanic Cloud. The data, which we obtained with the ESO Very Large Telescope, were analyzed using state-of-the-art stellar atmosphere models. We find that stellar winds of our sample stars are much weaker than theoretically expected. The stellar rotation rates show a bi-modal distribution. The well-populated upper Hertzsprung-Russell diagram including our sample OB stars from SMC Wing as well as additional evolved stars all over SMC from the literature shows a strict luminosity limit. The comparison with single-star evolutionary tracks suggests a dichotomy in the fate of massive stars in the SMC. Only stars with Minit30M$_{\odot}$ appear to stay always hot and might evolve quasi chemically homogeneously, finally collapsing to relatively massive black holes. However, we find no indication that chemical mixing is correlated with rapid rotation. We report extended star-formation episodes in a quiescent low-density region of the Wing, which is progressing stochastically. We measure the key parameters of stellar feedback and establish the links between the rates of star formation and supernovae. Our study reveals that in metal-poor environments the stellar feedback is dominated by core-collapse supernovae in combination with winds and ionizing radiation supplied by a few of the most massive stars., Accepted for publication in Astronomy & Astrophysics

The study of massive stars in different metallicity environments is a central topic of current stellar research. The spectral analysis of massive stars requires adequate model atmospheres. The computation of such models is difficult and time-consuming. Therefore, spectral analyses are greatly facilitated if they can refer to existing grids of models. Here we provide grids of model atmospheres for OB-type stars at metallicities corresponding to the Small and Large Magellanic Clouds, as well as to solar metallicity. In total, the grids comprise 785 individual models. The models were calculated using the state-of-the-art Potsdam Wolf-Rayet (PoWR) model atmosphere code. The parameter domain of the grids was set up using stellar evolution tracks. For all these models, we provide normalized and flux-calibrated spectra, spectral energy distributions, feedback parameters such as ionizing photons, Zanstra temperatures, and photometric magnitudes. The atmospheric structures (the density and temperature stratification) are available as well. All these data are publicly accessible through the PoWR website., 12 pages, 14 figures, accepted for publication in Astronomy & Astrophysics

Voltage-gated Na(+) channels (VGSCs) initiate action potentials thereby giving rise to rapid transmission of electrical signals along cell membranes and between cells. Depolarization of the cell membrane causes VGSCs to open but also gives rise to a nonconducting state termed inactivation. Inactivation of VGSCs serves a critical physiologic function as it determines the extent of excitability of neurons and of muscle cells. Depending on the time course of development and removal of inactivation both "fast-" and "slow"-inactivated states have been described. Evidence from mutagenesis studies suggests that fast inactivation is produced by a block of the internal vestibule by a tethered inactivation particle that has been mapped to the internal linker between domains III and IV. The motion of this linker may be regulated by parts of the internal C-terminus. The molecular mechanism of slow inactivation is less clear. However, aside from a high number of mutagenesis studies, the recent availability of 3D structures of crystallized prokaryotic VGSCs offers insights into the molecular motions associated with slow inactivation. One possible scenario is that slow movements of the voltage sensors are transmitted to the external vestibule giving rise to a conformational change of this region. This molecular rearrangement is transmitted to the S6 segments giving rise to collapse of the internal vestibule.

Massive WR stars are evolved massive stars characterized by strong mass-loss. Hypothetically, they can form either as single stars or as mass donors in close binaries. About 40% of the known WR stars are confirmed binaries, raising the question as to the impact of binarity on the WR population. By performing a spectral analysis of all multiple WR systems in the SMC, we obtain the full set of stellar parameters for each individual component. Mass-luminosity relations are tested, and the importance of the binary evolution channel is assessed. The spectral analysis is performed with the PoWR model atmosphere code by superimposing model spectra that correspond to each component. Evolutionary channels are constrained using the BPASS evolution tool. Significant Hydrogen mass fractions (0.1 - 0.4) are detected in all WN components. A comparison with mass-luminosity relations and evolutionary tracks implies that the majority of the WR stars in our sample are not chemically homogeneous. The WR component in the binary AB 6 is found to be very luminous (Log L ~ 6.3 [Lsun]) given its orbital mass (~10 Msun), presumably because of observational contamination by a third component. Evolutionary paths derived for our objects suggest that Roche lobe overflow had occurred in most systems, affecting their evolution. However, the implied initial masses are large enough for the primaries to have entered the WR phase, regardless of binary interaction. Together with the results for the putatively single SMC WR stars, our study suggests that the binary evolution channel does not dominate the formation of WR stars at SMC metallicity., Accepted for publication in A&A on 30 March, 2016. 15 + 10 pages, 8 + 8 figures

We present a comprehensive study of X-ray emission and wind properties of massive magnetic early B-type stars. Dedicated XMM-Newton observations were obtained for three stars xi1 CMa, V2052 Oph, and zeta Cas. We report the first detection of X-ray emission from V2052 Oph and zeta Cas. The observations show that the X-ray spectra of our program stars are quite soft. We compile the complete sample of early B-type stars with detected magnetic fields to date and existing X-ray measurements, in order to study whether the X-ray emission can be used as a general proxy for stellar magnetism. We find that hard and strong X-ray emission does not necessarily correlate with the presence of a magnetic field. We analyze the UV spectra of five non-supergiant B stars with magnetic fields by means of non-LTE iron-blanketed model atmospheres. The latter are calculated with the PoWR code, which treats the photosphere as well as the the wind, and also accounts for X-rays. Our models accurately fit the stellar photospheric spectra in the optical and the UV. The parameters of X-ray emission, temperature and flux are included in the model in accordance with observations. We confirm the earlier findings that the filling factors of X-ray emitting material are very high. Our analysis reveals that the magnetic early type B stars studied here have weak winds. The mass-loss rates are significantly lower than predicted by hydrodynamically consistent models. We find that, although the X-rays strongly affect the ionization structure of the wind, this effect is not sufficient in reducing the total radiative acceleration. When the X-rays are accounted for at the intensity and temperatures observed, there is still sufficient radiative acceleration to drive stronger mass-loss than we empirically infer from the UV spectral lines. (abridged)

Wolf-Rayet (WR) stars have a severe impact on their environments owing to their strong ionizing radiation fields and powerful stellar winds. Since these winds are considered to be driven by radiation pressure, it is theoretically expected that the degree of the wind mass-loss depends on the initial metallicity of WR stars. Following our comprehensive studies of WR stars in the Milky Way, M31, and the LMC, we derive stellar parameters and mass-loss rates for all seven putatively single WN stars known in the SMC. Based on these data, we discuss the impact of a low-metallicity environment on the mass loss and evolution of WR stars. The quantitative analysis of the WN stars is performed with the Potsdam Wolf-Rayet (PoWR) model atmosphere code. The physical properties of our program stars are obtained from fitting synthetic spectra to multi-band observations. In all SMC WN stars, a considerable surface hydrogen abundance is detectable. The majority of these objects have stellar temperatures exceeding 75 kK, while their luminosities range from 10^5.5 to 10^6.1 Lsun. The WN stars in the SMC exhibit on average lower mass-loss rates and weaker winds than their counterparts in the Milky Way, M31, and the LMC. By comparing the mass-loss rates derived for WN stars in different Local Group galaxies, we conclude that a clear dependence of the wind mass-loss on the initial metallicity is evident, supporting the current paradigm that WR winds are driven by radiation. A metallicity effect on the evolution of massive stars is obvious from the HRD positions of the SMC WN stars at high temperatures and high luminosities. Standard evolution tracks are not able to reproduce these parameters and the observed surface hydrogen abundances. Homogeneous evolution might provide a better explanation for their evolutionary past., Comment: 18+12 pages; 22+8 figures; accepted for publication in A&A

1987 berichtete Watanabe erstmals uber eine in 50% der Falle familiar auftretende gutartige Epilepsie mit komplexen Partialanfallen bei Sauglingen und Kleinkindern (BPEI). Die spater von Vigevano beschriebenen Familien wiesen alle von Watanabe definierten Kriterien auf, zeigten jedoch einen strikt autosomal-dominanten Erbgang und eine Kopplung auf Chromosom 19q. In ihrem neuesten Vorschlag fur ein Diagnoseschema akzeptiert die ILAE die beiden Syndrome als "benign-non familial/autosomal dominant-infantile seizures". Mit Hilfe einer multizentrischen Datenbank wurden 24 Patienten mit BPEI identifiziert. In 2 grosen betroffenen Familien wurde die genetische Kopplung auf Chromosom 19q analysiert. Alle Patienten erfullten die von Watanabe aufgestellten klinischen Kriterien, das interiktale EEG bot jedoch eine hohere Rate an Auffalligkeiten als bisher beschrieben. 14 der 24 Patienten hatten eine positive Familienanamnese fur benigne Epilepsien, in 2 Familien uber 3 Generationen. Die benignen NF/AD infantile seizures sind 2 hochstwahrscheinlich genetisch distinkte, klinisch aber sehr nah verwandte Epilepsiesyndrome mit gutartigem Verlauf. Das Spektrum der Watanabe-Epilepsie ist weiter als initial definiert; ein interiktal pathologisches EEG schliest die Diagnose dieses gutartigen Epilepsiesyndroms nicht aus.

Kleine-Levin syndrome (KLS) is a rare disorder which affects mainly adolescents. Periods of extreme somnolence alternate with megaphagia, psychomental changes and behavioural symptoms. The cause and pathogenesis of KLS remains unknown. Several treatments have been tried and recently lithium has been proposed for a prophylactic use in single cases. In view of the rarity of KLS, long-term results of lithium therapy have not been described yet. We report the clinical course of five adolescents with KLS who were treated with lithium. All patients showed significant EEG and polysomnographic changes during the episodes and had normal results in the interval. All patients had relapses while being treated with lithium. But episodes of hypersomnia under lithium therapy were shorter and monosymptomatic with lack of behavioural symptoms. Statistical modelling showed that the risk for a relapsing episode under maintenance of lithium drops per months of therapy from 100 % to 93 %, and furthermore that the maintenance of lithium shortens the mean duration of episodes to 19 %. No severe side effects were observed. In conclusion, in KLS with a high frequency of episodes and severe behavioural changes lithium may become a treatment option.

Context. Massive Wolf-Rayet stars are recognized today to be in a very common, but short, evolutionary phase of massive stars. While our understanding of Wolf-Rayet stars has increased dramatically over the past decades, it remains unclear whether rapid rotators are among them. There are various indications that rapidly rotating Wolf-Rayet stars should exist. Unfortunately, due to their expanding atmospheres, rotational velocities of Wolf-Rayet stars are very difficult to measure. However, recently observed spectra of several Wolf-Rayet stars reveal peculiarly broad and round emission lines. Could these spectra imply rapid rotation? Aims. In this work, we model the effects of rotation on the atmospheres of Wolf-Rayet stars. We further investigate whether the peculiar spectra of five Wolf-Rayet stars may be explained with the help of stellar rotation, infer appropriate rotation parameters, and discuss the implications of our results. Methods. We make use of the Potsdam Wolf-Rayet (PoWR) non-LTE model atmosphere code. Since the observed spectra of WolfRayet stars are mainly formed in their expanding atmospheres, rotation must be accounted for with a 3D integration scheme of the formal integral. For this purpose, we assume a rotational velocity field consisting of an inner co-rotating domain and an outer domain, where the angular momentum is conserved. Results. We find that rotation can reproduce the unique spectra analyzed here. However, the inferred rotational velocities at the stellar surface are large (similar to 200 km s(-1)), and the inferred co-rotation radii (similar to 10R.) suggest the existence of very strong photospheric magnetic fields (similar to 20 kG).

It is not yet clear whether magnetic fields play an essential role in shaping planetary nebulae (PNe), or whether stellar rotation alone and/or a close binary companion can account for the variety of the observed nebular morphologies. In a quest for empirical evidence verifying or disproving the role of magnetic fields in shaping PNe, we follow up on previous attempts to measure the magnetic field in a representative sample of PN central stars. We obtained low-resolution polarimetric spectra with FORS 2 at VLT for a sample of twelve bright central stars of PNe with different morphology, including two round nebulae, seven elliptical nebulae, and three bipolar nebulae. Two targets are Wolf-Rayet type central stars. For the majority of the observed central stars, we do not find any significant evidence for the existence of surface magnetic fields. However, our measurements may indicate the presence of weak mean longitudinal magnetic fields of the order of 100 Gauss in the central star of the young elliptical planetary nebula IC 418, as well as in the Wolf-Rayet type central star of the bipolar nebula Hen2-113 and the weak emission line central star of the elliptical nebula Hen2-131. A clear detection of a 250 G mean longitudinal field is achieved for the A-type companion of the central star of NGC 1514. Some of the central stars show a moderate night-to-night spectrum variability, which may be the signature of a variable stellar wind and/or rotational modulation due to magnetic features. We conclude that strong magnetic fields of the order of kG are not widespread among PNe central stars. Nevertheless, simple estimates based on a theoretical model of magnetized wind bubbles suggest that even weak magnetic fields below the current detection limit of the order of 100 G may well be sufficient to contribute to the shaping of PNe throughout their evolution., Comment: 16 pages, 11 figures, 3 tables, accepted for publication in A&A; References updated, minor corrections

Aims: Following our comprehensive studies of the WR stars in the Milky Way, we now present spectroscopic analyses of almost all known WN stars in the LMC. Methods: For the quantitative analysis of the wind-dominated emission-line spectra, we employ the Potsdam Wolf-Rayet (PoWR) model atmosphere code. By fitting synthetic spectra to the observed spectral energy distribution and the available spectra (ultraviolet and optical), we obtain the physical properties of 107 stars. Results: We present the fundamental stellar and wind parameters for an almost complete sample of WN stars in the LMC. Among those stars that are putatively single, two different groups can be clearly distinguished. While 12% of our sample are more luminous than 10^6 Lsun and contain a significant amount of hydrogen, 88% of the WN stars, with little or no hydrogen, populate the luminosity range between log (L/Lsun) = 5.3...5.8. Conclusions: While the few extremely luminous stars (log (L/Lsun) > 6), if indeed single stars, descended directly from the main sequence at very high initial masses, the bulk of WN stars have gone through the red-supergiant phase. According to their luminosities in the range of log (L/Lsun) = 5.3...5.8, these stars originate from initial masses between 20 and 40 Msun. This mass range is similar to the one found in the Galaxy, i.e. the expected metallicity dependence of the evolution is not seen. Current stellar evolution tracks, even when accounting for rotationally induced mixing, still partly fail to reproduce the observed ranges of luminosities and initial masses. Moreover, stellar radii are generally larger and effective temperatures correspondingly lower than predicted from stellar evolution models, probably due to subphotospheric inflation., 17+46 pages; 10+54 figures; v2: typos corrected, space-saving layout for appendix C, published in A&A

We describe a mutation in the outer vestibule region of the adult rat skeletal muscle voltage-gated Na+ channel (microliter) that dramatically alters binding of mu-conotoxin GIIIA (mu-CTX). Mutating the glutamate at position 758 to glutamine (E758Q) decreased mu-CTX binding affinity by 48-fold. Because the mutant channel showed both low tetrodotoxin (TTX) and mu-CTX affinities, these results suggested that mu-CTX bound to the outer vestibule and implied that the TTX- and mu-CTX-binding sites partially overlapped in this region. The mutation decreased the association rate of the toxin with little effect on the dissociation rate, suggesting that Glu-758 could be involved in electrostatic guidance of mu-CTX to its binding site. We propose a mechanism for mu-CTX block of the Na+ channel based on the analogy with saxitoxin (STX) and TTX, on the requirement of mu-CTX to have an arginine in position 13 to occlude the channel, and on this experimental result suggesting that mu-CTX binds in the outer vestibule. In this model, the guanidinium group of Arg-13 of the toxin interacts with two carboxyls known to be important for selectivity (Asp-400 and Glu-755), with the association rate of the toxin increased by interaction with Glu-758 of the channel.

The massive Wolf-Rayet type star WR 102c is located near the Quintuplet Cluster - one of the three massive star clusters in the Galactic Center region. Previous studies indicated that WR 102c may have a dusty circumstellar nebula and is among the main ionizing sources of the Sickle Nebula associated with the Quintuplet cluster. We obtained observations with the ESO's VLT integral field spectrograph SINFONI in the K-band, extracted the stellar spectra, and analyzed them by means of stellar atmosphere models. Our new analysis supersedes the results reported for WR 102c previously. We significantly revise down its bolometric luminosity and hydrogen content. We detect four early OB type stars close to WR 102c. These stars have radial velocities similar to that of WR 102c. We suggest that together with WR 102c these stars belong to a distinct star cluster with a total mass of about 1000 M_sun. We identify a new WR nebula around WR 102c in the SINFONI map of the diffuse Br$\gamma$ emission and in the HST's Pa$\alpha$ images. The Br$\gamma$ line at different locations is not significantly broadened and similar to the width of nebular emission elsewhere in the H II region around WR 102c. The massive star WR 102c located in the Galactic Center region resides in a star cluster containing further early type stars. The stellar parameters of WR 102c are typical for hydrogen-free WN6 stars. We newly identify a nebula surrounding WR 102c that has a morphology similar to other nebulae around hydrogen-free WR stars, and propose that the formation of this nebula is linked to interaction of the fast stellar wind with the matter ejected at previous evolutionary stage of WR 102c., Comment: 10 pages, 10 figures, accepted for publication in A&A

Forty-two women, meeting criteria for bulimia, completed the MMPI. Cluster analysis of their scores revealed two distinct profile types. The first cluster, comprising about 64% of subjects, produced a mean profile in which only the Pd scale exceeded a t score of 70. In contrast, about 36% of subjects yielded a cluster-derived mean profile that was significantly elevated on many scales, including Pd, D, Pt, and Sc. The existence of these two very different subgroups of women with bulimia replicates previous work in this area and has potentially important implications for the description, treatment, and general understanding of those with this condition.

Sk 183 is the visually-brightest star in the N90 nebula, a young star-forming region in the Wing of the Small Magellanic Cloud (SMC). We present new optical spectroscopy from the Very Large Telescope which reveals Sk 183 to be one of the most massive O-type stars in the SMC. Classified as an O3-type dwarf on the basis of its nitrogen spectrum, the star also displays broadened He I absorption which suggests a later type. We propose that Sk 183 has a composite spectrum and that it is similar to another star in the SMC, MPG 324. This brings the number of rare O2- and O3-type stars known in the whole of the SMC to a mere four. We estimate physical parameters for Sk 183 from analysis of its spectrum. For a single-star model, we estimate an effective temperature of 46+/-2 kK, a low mass-loss rate of ~10^-7 Msun yr^-1, and a spectroscopic mass of 46^+9_-8 Msun (for an adopted distance modulus of 18.7 mag to the young population in the SMC Wing). An illustrative binary model requires a slightly hotter temperature (~47.5 kK) for the primary component. In either scenario, Sk 183 is the earliest-type star known in N90 and will therefore be the dominant source of hydrogen-ionising photons. This suggests Sk 183 is the primary influence on the star formation along the inner edge of the nebula., Comment: Accepted by ApJ, 10 pages, 7 figures, v2 after proofs

We investigate the connections between the magnetic fields and the X-ray emission from massive stars. Our study shows that the X-ray properties of known strongly magnetic stars are diverse: while some comply to the predictions of the magnetically confined wind model, others do not. We conclude that strong, hard, and variable X-ray emission may be a sufficient attribute of magnetic massive stars, but it is not a necessary one. We address the general properties of X-ray emission from "normal" massive stars, especially the long standing mystery about the correlations between the parameters of X-ray emission and fundamental stellar properties. The recent development in stellar structure modeling shows that small scale surface magnetic fields may be common. We suggest a "hybrid" scenario which could explain the X-ray emission from massive stars by a combination of magnetic mechanisms on the surface and shocks in the stellar wind. The magnetic mechanisms and the wind shocks are triggered by convective motions in sub-photospheric layers. This scenario opens the door for a natural explanation of the well established correlation between bolometric and X-ray luminosities., Accepted AN. 2011 Potsdam Thinkshop "Magnetic Fields in Stars and Exoplanets"

With the help of detailed nebula modeling and X‐ray observations, we want to shed light on the enigmatic origin of Wolf‐Rayet type central stars of planetary nebulae. This method allows us to assign observed [WC] stars to one of the proposed evolutionary scenarios, attributing the loss of hydrogen to a “late”, “very late”, or an “AGB final” thermal pulse (LTP, VLTP and AFTP, respectively). We conclude that BD+30° 3639 evolved through an AFTP.

Based on $K$-band integral-field spectroscopy, we analyze four Wolf-Rayet stars of the nitrogen sequence (WN) found in the inner part of the Quintuplet cluster. All WN stars (WR102d, WR102i, WR102hb, and WR102ea) are of spectral subtype WN9h. One further star, LHO110, is included in the analysis which has been classified as Of/WN? previously but turns out to be most likely a WN9h star as well. The Potsdam Wolf-Rayet (PoWR) models for expanding atmospheres are used to derive the fundamental stellar and wind parameters. The stars turn out to be very luminous, $\log{(L/L_\odot)} > 6.0$, with relatively low stellar temperatures, $T_* \approx$ 25--35\,kK. Their stellar winds contain a significant fraction of hydrogen, up to $X_\mathrm{H} \sim 0.45$ (by mass). We discuss the position of the Galactic center WN stars in the Hertzsprung-Russell diagram and find that they form a distinct group. In this respect, the Quintuplet WN stars are similar to late-type WN stars found in the Arches cluster and elsewhere in the Galaxy. Comparison with stellar evolutionary models reveals that the Quintuplet WN stars should have been initially more massive than 60\,$M_\odot$. They are about 2.1 to 3.6\,Million years old, and might still be central hydrogen burning objects. The analysis of the spectral energy distributions of the program stars results in a mean extinction of $A_K = 3.1 \pm 0.5$\,mag ($A_V = 27 \pm 4$\,mag) towards the Quintuplet cluster., 9 pages, 7 figures, 4 tables, article published in A&A (with better layout)

Hydrogen‐deficient central stars are commonly considered as the progenitors of H‐deficient white dwarfs. Spectroscopically, many H‐deficient central stars resemble massive Wolf‐Rayet stars of the carbon sequence and are therefore classified as [WC] stars. The massive WR stars of the nitrogen sequence (WN), however, have no spectroscopic counterpart among the central stars. With PB 8 we found for the first time a central star with a WR‐type emission line spectrum that resembles the nitrogen sequence with only a slight enhancement of carbon lines, and therefore we classified this star as [WN/C]. Our analysis reveals that its atmosphere consists mainly of helium, with some hydrogen and only traces of carbon, nitrogen, and oxygen. This is very different from any other Wolf‐Rayet type central stars. The results of our analyses, especially the chemical composition, strongly constrains possible scenarios for the formation of PB 8. For the time being, we don’t know any path of single‐star evolution that could explain this enigmatic central star. In this context, we will also discuss the status of the central star of PMR 5, which is another candidate for a [WN] spectral type.

A considerable fraction of the central stars of planetary nebulae (CSPNe) are hydrogen-deficient. As a rule, these CSPNe exhibit a chemical composition of helium, carbon, and oxygen with the majority showing Wolf-Rayet-like emission line spectra. These stars are classified as CSPNe of a spectral type [WC]. We perform a spectral analysis of CSPN PB 8 with the Potsdam Wolf-Rayet (PoWR) models for expanding atmospheres. The source PB 8 displays wind-broadened emission lines from strong mass loss. Most strikingly, we find that its surface composition is hydrogen-deficient, but not carbon-rich. With mass fractions of 55% helium, 40% hydrogen, 1.3% carbon, 2% nitrogen, and 1.3% oxygen, it differs greatly from the 30-50% of carbon which are typically seen in [WC]-type central stars. The atmospheric mixture in PB 8 has an analogy in the WN/WC transition type among the massive Wolf-Rayet stars. Therefore we suggest to introduce a new spectral type [WN/WC] for CSPNe, with PB 8 as its first member. The central star of PB 8 has a relatively low temperature of T=52kK, as expected for central stars in their early evolutionary stages. Its surrounding nebula is less than 3000 years old, i.e. relatively young. Existing calculations for the post-AGB evolution can produce hydrogen-deficient stars of the [WC] type, but do not predict the composition found in PB 8. We discuss various scenarios that might explain the origin of this unique object., Comment: 10 pages, 10 figures

Context. beta Cep-type variables are early B-type stars that are characterized by oscillations observable in their optical light curves. At least one beta Cep-variable also shows periodic variability in X-rays. Aims. Here we study the X-ray light curves in a sample of beta Cep-variables to investigate how common X-ray pulsations are for this type of stars. Methods. We searched the Chandra and XMM-Newton X-ray archives and selected stars that were observed by these telescopes for at least three optical pulsational periods. We retrieved and analyzed the X-ray data for kappa Sco, beta Cru, and alpha Vir. The X-ray light curves of these objects were studied to test for their variability and periodicity. Results. While there is a weak indication for X-ray variability in beta Cru, we find no statistically significant evidence of X-ray pulsations in any of our sample stars. This might be due either to the insufficient data quality or to the physical lack of modulations. New, more sensitive observations should settle this question.

We present the XMM-Newton discovery of X-ray emission from the planetary nebula (PN) A78, the second born-again PN detected in X-rays apart from A30. These two PNe share similar spectral and morphological characteristics: They harbor diffuse soft X-ray emission associated with the interaction between the H-poor ejecta and the current fast stellar wind, and a point-like source at the position of the central star (CSPN). We present the spectral analysis of the CSPN, using for the first time a NLTE code for expanding atmospheres which takes line blanketing into account for the UV and optical spectra. The wind abundances are used for the X-ray spectral analysis of the CSPN and the diffuse emission. The X-ray emission from the CSPN in A78 can be modeled by a single C VI emission line, while the X-ray emission from its diffuse component is better described by an optically thin plasma emission model with temperature $kT$=0.088 keV ($T\approx$1.0$\times$10${^6}$ K). We estimate X-ray luminosities in the 0.2--2.0 keV energy band of $L_{\mathrm{X,CSPN}}$=(1.2$\pm$0.3)$\times$10$^{31}$ erg~s$^{-1}$ and $L_{\mathrm{X,DIFF}}$=(9.2$\pm$2.3)$\times$10$^{30}$ erg~s$^{-1}$ for the CSPN and diffuse components, respectively., 12 pages, 10 figures, 2 tables; Accepted to Astrophysical Journal

We analyze the expansion of hydrogen-poor knots and filaments in the born-again planetary nebulae A30 and A78 based on Hubble Space Telescope (HST) images obtained almost 20 yr apart. The proper motion of these features generally increases with distance to the central star, but the fractional expansion decreases, i.e., the expansion is not homologous. As a result, there is not a unique expansion age, which is estimated to be 610-950 yr for A30 and 600-1140 yr for A78. The knots and filaments have experienced complex dynamical processes: the current fast stellar wind is mass loaded by the material ablated from the inner knots; the ablated material is then swept up until it shocks the inner edges of the outer, hydrogen-rich nebula. The angular expansion of the outer filaments shows a clear dependence on position angle, indicating that the interaction of the stellar wind with the innermost knots channels the wind along preferred directions. The apparent angular expansion of the innermost knots seems to be dominated by the rocket effect of evaporating gas and by the propagation of the ionization front inside them. Radiation-hydrodynamical simulations show that a single ejection of material followed by a rapid onset of the stellar wind and ionizing flux can reproduce the variety of clumps and filaments at different distances from the central star found in A30 and A78., Comment: 12 pages, 7 figures. Accepted for publication in the ApJ

Previous spectral analyses of Wolf‐Rayet type central stars resulted in different abundance patterns for late‐ and early [WC] subtypes, which could not be explained in the framework of post‐AGB evolutionary scenarios with any form of a late thermal pulse. Presently we re‐analyze systematically these stars, using the most recent version of our non‐LTE models for expanding atmospheres which now account for line blanketing by the iron‐group elements. So far we revisited the early subtypes. Although for some stars the carbon abundances are revised upwards, they are still only between 24 and 40% by mass and thus systematically lower than for late subtypes. This is inconsistent with an evolutionary sequence [WCL] → [WCE].

The proarrhythmic potential of therapeutic drugs can be evaluated by in-vivo electrophysiological testing using stimulated bradycardias. Since conventional stimulators are limited in the number of bradycardic beats, they cannot be used to evaluate the dynamic change of QT-intervals from the onset of bradycardia until a steady state has been achieved. Therefore, we designed and implemented a computer-based programmable stimulator, that enables complex stimulation protocols. This application was then rested in an experimental guinea-pig model to evaluate the characteristics of droperidol-induced QT-interval prolongation.