46 results on '"H. Pae"'
Search Results
2. Does intra-firm diffusion of innovation lead to inter-firm relationship benefits? The cases of innovation providers and adopters
- Author
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Namwoon Kim and Jae H. Pae
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Marketing ,Organizational innovation ,Phone ,business.industry ,Management support ,Mail questionnaire ,Business ,Directory ,Business and International Management ,Customer relationship management ,Affect (psychology) ,Diffusion of innovations - Abstract
Purpose – This study aims to fill the void of previous research in organizational innovation. The understanding of the factors that affect intra-firm diffusion of innovations, which include the proactive management support and participation comprehensiveness from the adopting firm, as well as the provider’s support of innovation utilization has been advanced. In addition, the extent to which the consequent intra-firm diffusion affects both the adopter’s and provider’s benefits has been explored based on their relationship. Design/methodology/approach – A mail questionnaire on the organizational purchase and utilization of customer relationship management (CRM)-type database systems was developed for collecting data. A random sample of 480 firms from the Hong Kong Chambers of Commerce Directory was obtained. From the initial phone calls, 343 firms currently using a CRM-type database system were identified, and the questionnaires were mailed to the managers of these firms. In total, 163 responses were finally returned with usable data, for a response rate of 47.5 per cent. Findings – The current study focuses on the causes and the effects associated with successful diffusion and utilization of innovation within a firm. Using data from business-to-business markets, the results find that the two parties involved benefit when both proactively participate in the intra-firm diffusion process; that is, benefits are created for the adopter via improvement in efficiency; and for the provider via establishment of a long-term relationship and switching costs. Research limitations/implications – First, any moderating impact of the adopting firm’s technological capabilities was not analyzed. Second, the research results were obtained from a sample of software product innovations (especially database management system). Even though it could be assumed that these results can also be applicable to other types of innovations (e.g. process innovations), empirical tests of our framework based on different innovation typologies are still warranted. Practical implications – First, for an innovation-adopting firm, we have shown that a wide use of purchased innovations among the organizational members is at least as important as the adoption of new innovations. Second, we have included the participation comprehensiveness of adoption decision, arguing that the organizational decision-making process is also crucial to stimulating intra-firm diffusion. Finally, and more importantly, our study calls attention to the provider’s role in expediting intra-firm diffusion. Originality/value – First, we have suggested an analytic framework for intra-firm diffusion of an innovation and also provided its empirical support. Particularly, the current study has focused on the subsequent effects of intra-firm diffusion on both the adopter’s and the provider’s benefits. Second, we have examined further impact of the comprehensive participation of adoption decision on spreading innovation information, which subsequently stimulates the innovation’s intra-firm diffusion.
- Published
- 2014
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3. Cooperate 'and' compete: coopetition strategy in retailer‐supplier relationships
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Leslie S.C. Yip, Namwoon Kim, Jae H. Pae, and Stephen K. Kim
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Marketing ,Competition (economics) ,Vertical channel ,Flexibility (personality) ,Coopetition ,Business ,Business and International Management ,Outcome (game theory) ,Competitive advantage ,Communication channel - Abstract
PurposeThis study aims to examine the strategic implications and managerial outcomes of the concurrent use of cooperation and competition in vertical channel relationships.Design/methodology/approachThis study employs a structured questionnaire to gather data regarding vertical channel relationships in China.FindingsWhereas the academic literature has emphasized cooperation between channel members because of the interdependence between them, in reality, retailers may accept competition as just another part of doing business with suppliers.Research limitations/implicationsThe outcome variables used may not be comprehensive. In particular, the authors choose the flexibility of channel resources to stand for private benefits and joint benefits to represent common benefits, and though these variables certainly represent the intended benefits of the ambidextrous strategy, it remains to be seen whether other benefits may emerge for the exchange parties in vertical relationships.Practical implicationsUsing an ambidextrous strategy does not damage relationship quality, though it certainly does not enhance it. This view is based on the notion that an ambidextrous strategy at least does not harm either common or private benefits. Therefore, exchange parties using the ambidextrous strategy should not experience a relationship that is worse than that which results when they use cooperation or competition alone. The results of the current study indicate that this view reflects reality more accurately.Originality/valueThe value of the current study centers on the application of a conceptual framework regarding ambidextrous strategy to vertical channel relationships in a developing economy.
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- 2013
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4. The Effect of the Perceived Corporate Fit on Loyalty: The Mediating Roles of the Corporate Social Responsibility Perception
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Jae H. Pae and Eun Mi Lee
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Core business ,business.industry ,media_common.quotation_subject ,Social environment ,Social Welfare ,Public relations ,Corporation ,Profit (economics) ,Perception ,Loyalty ,Corporate social responsibility ,Business ,Marketing ,media_common - Abstract
With the changes in the economic and social environment of companies, the dimensions of corporate responsibility have been greatly expanded. Now, firms should operate not only for their own profit but also for social welfare. Recently CSR (Corporate Social Responsibility) has been studied as an important construct in academia and highlighted as a pressing item on the practical corporate agenda (Covin, 2001; Sen and Bhattacharya, 2001). As consumers have been lately more interested in CSR, CSR activities are recognized as a sort of investment for higher company values, so that strategic CSR activities become more critical (Dean, 2003). In order to conduct CSR activities more effectively, it is necessary to examine ways to persuade consumers to pay attention to CSR activities. That is, this study examines the factors that affect consumer perception of CSR activities. Most previous studies consider only dimensions of perceived fit with a corporation's core business and there is little empirical rese...
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- 2011
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5. Immunoendocrinology and metabolism (PP-013)
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S. V. Kaveri, L. Rokbani, V. Lazanovich, I. A. Tuzankina, H. Ida, M. Mnif, A. P. Godovalov, V. Rumjanek, L. S. Paiva, Y. Joe, J. I. Shilov, K. Masuko, F. Boussema, R. Borojevic, E. Quivy, S. Ben Salah, S. Shagarova, H. Chung, H. Nakashima, N. Shinomiya, F. L. Oliveira, M. Kinoshita, J. Sim, M. Nakashima, Y. Aoyagi, D. Rodriguez, D. A. Drometr, M. Salmi, S. Ketari, H. Goto, K. Aalto, D. Wakita, N. Ksouri, J. Kranich, F. Furukawa, C. C. Pazos-Moura, N. Kanazawa, M. Gidlund, D. Shin, E. Ramos Sanchez, Z. Aydi, S. Kim, F. Mnif, M. Abid, S. Koizumi, H. Pae, J. Chung, T. Nishimura, N. Makiuchi, H. Fourati, H. Sugino, V. de Mello-Coelho, S. Tanaka, O. Cherif, K. M. Maslowski, A. Navarrete, S. Dogadin, K. Yoshiura, C. R. Mackay, M. Matsunaka, S. Delignat, S. Shono, A. Cordeiro, B. Ben Dhaou, H. Masmoudi, H. Jeong, O. Raitakari, M. Maksimow, F. F. Bloise, J. D. Dimitrov, N. Charfi, F. Sierro, S. Jalkanen, H. Kitamura, A. Sato, A. Savchenko, E. V. Markelova, S. T. Grey, S. Seki, V. Manchuk, S. Dasgupta, Y. Habu, R. Mitamura, N. Rekik, S. Lacroix-Desmazes, and M. Zheng
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medicine.medical_specialty ,Endocrinology ,Chemistry ,Internal medicine ,Immunology ,medicine ,Immunology and Allergy ,General Medicine ,Metabolism - Published
- 2010
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6. Utilization of business technologies: Managing relationship-based benefits for buying and supplying firms
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Namwoon Kim, Rajendra K. Srivastava, Jin K. Han, and Jae H. Pae
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Marketing ,Focus (computing) ,Procurement ,Service-orientation ,business.industry ,Enterprise relationship management ,Organizational culture ,Context (language use) ,Business ,Customer relationship management ,Industrial organization ,Business relationship management - Abstract
There is increasing evidence to suggest that organizations often fail to fully capitalize on the purchased business technologies due to their failure to utilize the new procurement throughout their corporate system. To this end, this study sets out to identify the factors that play a tangible role in facilitating the utilization of procured business technologies. In this context, we not only examine the direct effects of technology and organizational culture on utilization, but also assess the moderating effects of user environments and supplier service orientation on these direct relationships. More importantly, we focus on the impact of utilization in creating the relationship-based benefits for both the technology user and supplier. Using data on purchase and use of customer relationship management (CRM) system, we empirically validate that the user firm's corporate culture, perceived technology attributes, environmental turbulence, and the supplying firm's service orientation are critical in increasing the utilization level of business technologies, which in turn helps to create/sustain relationship-based advantages for both parties.
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- 2010
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7. Commitment and vulnerability in B2B relationship selling in the Hong Kong institutional insurance service industry
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Jae H. Pae, T.K.P. Leung, Ricky Y. K. Chan, and Y. H. Wong
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Marketing ,business.industry ,media_common.quotation_subject ,Vulnerability ,Test (assessment) ,Personalization ,Microeconomics ,Negative relationship ,Service (economics) ,Loyalty ,Business ,Relationship marketing ,Tertiary sector of the economy ,media_common - Abstract
PurposeThe purpose of this paper is to understand the impact of the antecedents of the exchange domain (use of coercive influence, ideational favor exchange, calculative resource‐dependence, and decision uncertainty) on relationship building. The paper examines the link between the two mediating dynamics of embedded trust and relationship‐specific customization and loyalty by developing a model of vulnerability‐based commitment.Design/methodology/approachThe links between the model elements are tested using data from a survey of clients in the Hong Kong insurance service. Structural equation analysis is used to test research hypotheses and to examine the extent to which vulnerability‐based commitment leads to the development of loyalty.FindingsThe degree of embedded trust between parties is enhanced by the use of coercive influence, favor, and resource‐dependence. Embedded trust has a negative relationship with decision uncertainty. The antecedents of coercive influence, favor, and resource‐dependence have positive impacts on relationship‐specific customization. Vulnerability‐based commitment is positively affected both by trust and customization whilst commitment has a positive impact on loyalty.Practical implicationsA vulnerability‐based commitment model is developed as an analytical and managerial tool for understanding the benefits and hidden vulnerabilities of client loyalty and for implementing effective service strategies.Originality/valueBy understanding the implications of the benefits/costs in commitment vulnerabilities, the findings can help in the design of a loyalty quality system. A new measurement tool is provided to enable researchers to perform more vigorous scale development of commitment.
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- 2008
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8. Utilization of new technologies: organizational adaptation to business environments
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Jae H. Pae and Namwoon Kim
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Marketing ,Economics and Econometrics ,Lead (geology) ,business.industry ,Emerging technologies ,Business and International Management ,Customer relationship management ,business ,Competitive advantage ,Organizational adaptation ,Industrial organization - Abstract
The practice of introducing new technologies into the corporate environment has become a well-accepted principle for sustaining or advancing competitive advantages. The current study focuses on the environmental and managerial factors associated with the successful utilization of new technologies. To this end, the suggested framework examines the efforts put forth by the two parties involved (the firm buying and the firm supplying the new technology). We use 112 matched data collected from the suppliers and buyers of the customer relationship management (CRM) system in business-to-business markets. We find that the perceived turbulence of business environments stimulates adaptive efforts from both the supplying and buying firms, which may lead to a high level of utilization of new technologies for the buying firm.
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- 2007
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9. Consumers' 'mental accounting' in response to unexpected price savings at the point of sale
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Hwan Ho Ha, Jae H. Pae, and Jung Suk Hyun
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Marketing ,Point of sale ,Mental accounting ,Context (language use) ,Advertising ,Commit ,Business ,computer.software_genre ,computer ,Purchasing ,Consumer behaviour ,Test (assessment) - Abstract
PurposeTo investigate shoppers' decision‐making behaviour under conditions of expected and unexpected in‐store price discounts, using mental accounting theory as the analytical framework.Design/methodology/approachIn an experiment manipulating expected and unexpected discounts on electronic organisers and portable audio players, data collected by questionnaire from 240 first‐year business administration students at a Korean university were used to test two hypotheses predicting the ways in which the savings would be used.FindingsRecipients of unexpected discounts tend to spend the savings in store. If a choice of two products is available, the savings are more likely to be applied to the discounted one than the other. Shoppers commit more actively to planned purchases when price discounts are known in advance. The key factor in purchasing behaviour with respect to discounts is the existence or otherwise of predictions. Shoppers' decision‐making in these conditions is, therefore, context and frame dependent.Research limitations/implicationsThe experimental subjects were not representative of the general shopping population, and Korea is a distinctive culture. The findings should be interpreted with caution, but are indicative within limits. Aspects of the topic not investigated by the experiment are identified, and future research directions suggested.Practical implicationsUnadvertised discount available at the point of sale offer several potential benefits to retailers, including reduced costs and increased patronage. Pricing strategists need to understand the theoretical basis of customers' behaviour in response to discount offers, for effective planning.Originality/valueAdds to the body of knowledge relating to crucial aspect of pricing strategy, and has potential applicability beyond retailing.
- Published
- 2006
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10. Antecedents and consequences of the strategic orientations in new product development: The case of Chinese manufacturers
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Jae H. Pae, Dongsheng Zhou, and Insik Jeong
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Marketing ,Strategic planning ,Knowledge management ,business.industry ,media_common.quotation_subject ,Context (language use) ,Strategic orientation ,Customer orientation ,New product development ,Conceptual model ,Field research ,Manufacturing firms ,Business ,Industrial organization ,media_common - Abstract
The objective of the present study is to advance the understanding of the role of the strategic orientation of the firm for successful new product development (NPD), in the context of Chinese manufacturing firms. Through field research accompanied by a review of the related literature, this study identifies customer orientation and technology orientation as crucial strategic components that are important to successful new product development. This research proposes a conceptual model of strategic orientations, in which firm-internal (organizational support) and -external (environmental turbulence) factors are expected to influence strategic orientations, which, in turn, impact NPD performance. The model is tested using data collected from a large-scale survey of 232 manufacturing firms in China. The results largely support the hypotheses derived from the conceptual model. First, organizational support and environmental turbulence have a positive influence on the implementation of strategic orientations. Second, the two strategic orientations show a different pattern of performance implications.
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- 2006
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11. Technology advancement strategy on patronage decisions: the role of switching costs in high-technology markets
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Jung Suk Hyun and Jae H. Pae
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Information Systems and Management ,Consumer survey ,Empirical research ,Explication ,Strategy and Management ,Economics ,Current technology ,Management Science and Operations Research ,Marketing ,Complementary good - Abstract
Among the many factors that encourage return patronage of incumbent technologies, one that has received scholarly attention in other contexts is switching costs. The existing literature, however, has yet to provide a detailed explication of the underlying processes involved to link switching costs and technology patronage. Furthermore, no examination has been conducted of the degree to which the factor plays a role in the success or failure of corporate technology advancement strategies designed to encourage technology patronage. In this context, we propose a systematic framework to explore the nature of the links between technology advancement strategies and consumer technology patronage via switching costs. Based on consumer survey data from South Korea, we find empirical support for the link between technology advancement strategies and consumers' technology commitment and patronage. Specifically, switching costs are found to be positively associated with technology commitment and patronage. Further, compatibility strategy is associated with the costs involved in switching away from incumbent technology because of an abundant or varied supply of complementary goods. The results also show that preannouncement is a key communication strategy to achieve favorable expectations and to retain the commitment and patronage of current technology users.
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- 2006
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12. Noise-driven multistability in a plasma diode
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K. H. Pae, Ju Tae Seo, and Sang June Hahn
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Physics ,Work (thermodynamics) ,Fractal ,Numerical noise ,Condensed matter physics ,Quantum electrodynamics ,Attractor ,Plasma ,Condensed Matter Physics ,Multistability ,Noise (radio) ,Diode - Abstract
Recently, a brand-new phenomenon of competing multistability in plasma diode systems has been observed by our group [S. J. Hahn and K. H. Pae, Phys. Plasmas 10, 314 (2003)]. By employing one-dimensional particle-in-cell simulations with proper control of the inherent numerical noise, the noise-driven multistability and dynamical transitions between regular and multistable solutions have been investigated. Throughout this work, it is verified that the competing multistability is, in principle, a noise-driven dynamical switch between attractors and occurs due to noise fluctuations inside a system near the fractal basin boundaries.
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- 2004
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13. Enhancement of high-energy ion generation by preplasmas in the interaction of an intense laser pulse with overdense plasmas
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Hyyong Suk, S. J. Hahn, Hae June Lee, and K. H. Pae
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Physics ,High energy ,business.industry ,Pulse duration ,Plasma ,Condensed Matter Physics ,Laser ,law.invention ,Ion ,Pulse (physics) ,symbols.namesake ,Optics ,Physics::Plasma Physics ,law ,Laser intensity ,symbols ,Atomic physics ,business ,Doppler effect - Abstract
High-energy ion generation from the interaction of an ultraintense subpicosecond laser pulse with an overdense plasma slab combined with an underdense preplasma has been studied by using fully electromagnetic and relativistic particle-in-cell simulations. It was observed that the forward ion acceleration from the front and rear surfaces can be enhanced with a proper preplasma profile. The energy distribution functions of the accelerated ions, and Doppler shift of the reflected laser pulse are investigated with the variation of laser intensity, pulse duration, and preplasma profiles.
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- 2004
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14. Multigeneration Innovation Diffusion: The Impact of Intergeneration Time
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Jae H. Pae and Donald R. Lehmann
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Marketing ,Economics and Econometrics ,Emerging technologies ,media_common.quotation_subject ,Innovation diffusion ,Economics ,Production (economics) ,Business and International Management ,Imitation ,Industrial organization ,media_common - Abstract
This research focuses on the diffusion patterns of the adjacent generations of technology and its relation to the time that elapses between them (intergeneration time). The authors analyze 45 new technologies in 15 industries and find that the adoption curves systematically vary across generations from 2 years for dynamic random-access memory (DRAM) chips to more than 30 years for steelmaking. The longer the intergeneration time, the slower the adoption of the subsequent technology. Even though once the adoption begins imitation is greater for subsequent technologies, the slow initial innovation rate, driven by resistance to upgrading, retards adoption. The authors also demonstrate that predictions based on intergeneration time plus average patterns are more accurate than data-based predictions early in life cycles when such predictions are most crucial. Improved early predictions can provide advantages in terms of both making go versus no-go decisions and planning marketing and production.
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- 2003
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15. Managing intraorganizational diffusion of innovations
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Namwoon Kim, Leslie S.C. Yip, Jae H. Pae, and Jin K. Han
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Marketing ,Organizational innovation ,Knowledge management ,business.industry ,Dynamics (music) ,Context (language use) ,Center (algebra and category theory) ,Percept ,business ,Diffusion of innovations - Abstract
Companies often introduce organizational innovations into their corporate environment with the aim of improving their operational efficiencies. While this practice has become a well-accepted percept among both practitioners and academics over the years for its intuitive appeal, there is an increasing evidence to suggest that companies often fail to fully capitalize on the adopted innovation throughout their organizations. To this end, this study sets out to identify the factors that play a tangible role in facilitating the intraorganizational diffusion of innovations. In this context, we not only examine the roles of buying center dynamics and environments in the intraorganizational diffusion process but also assess the impact on the innovation-adopting firm through the high level of intraorganizational diffusion.
- Published
- 2002
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16. Self-Oscillation and Chaos in Positive-Bias Plasma Diodes
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K. H. Pae and Sang June Hahn
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Period-doubling bifurcation ,Physics ,Condensed matter physics ,General Physics and Astronomy ,Self-oscillation ,Spectral line ,law.invention ,Power (physics) ,Nonlinear Sciences::Chaotic Dynamics ,CHAOS (operating system) ,Quasiperiodicity ,law ,Intermittency ,Attractor ,Atomic physics - Abstract
The time-dependent spatio-temporal structures in positive-bias plasma diodes are investigated by employing a one-dimensional particle simulation. Nonlinear evolution of a large-amplitude self-oscillation and transitions to chaos are analyzed by using the time-varying potential profiles and their power spectra. The three standard routes to chaos (period doubling, intermittency, and quasiperiodicity) are observed and the first observation of the attractor-competing phenomena is also reported.
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- 2002
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17. The impact of technology advancement strategies on consumers' patronage decisions
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Jae H. Pae and Jung Suk Hyun
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Management of Technology and Innovation ,Strategy and Management - Published
- 2002
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18. Global advertising strategy
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Saeed Samiee, Jae H. Pae, and Susan Tai
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Marketing ,Marketing mix modeling ,business.industry ,Brand awareness ,Advertising ,Marketing strategy ,Advertising research ,Brand management ,Advertising campaign ,Transformational leadership ,Business and International Management ,business ,Native advertising - Abstract
The significant body of published work in global advertising literature focuses on the standardization and localization of the advertising campaign from a marketing strategy perspective without much concern regarding consumers’ response. In this research, this gap is addressed by gauging consumer perceptions of localized and standardized advertisements in Hong Kong. Consumers generally prefer locally produced to foreign‐sourced commercials, irrespective of brand origin; and they exhibit more favorable attitudes toward foreign‐sourced, standardized commercials in situations involving greater brand familiarity and when execution style is transformational. Therefore, well‐known brands with transformational appeals are more likely to succeed when transferred to Hong Kong, while localized advertising messages will be more effective when brand familiarity is low.
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- 2002
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19. Effects of TV Advertising on Chinese Consumers: Local versus Foreign-Sourced Commercials
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Susan H.C. Tai and Jae H. Pae
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Marketing ,Strategy and Management ,Perception ,media_common.quotation_subject ,Perspective (graphical) ,Significant difference ,Advertising ,Business ,China ,Style (sociolinguistics) ,media_common - Abstract
The emerging Chinese markets of Asia are increasingly affluent, and success in these countries is a priority for multinationals. Yet the global advertising literature focuses on standardisation and customisation from a strategy perspective, without much consideration of consumers' perceptions toward advertising. This study aims to investigate consumer perceptions of customised and standardised TV advertisements in the China market. Results indicate a significant difference between attitudes toward localised and foreign-sourced commercials for the same brand. Chinese consumers generally prefer foreign-sourced, standardised commercials to their localised counterparts. Furthermore, standardised commercials are more likely to gain acceptance in the case of durable products. The moderating roles of brand familiarity and execution style on the advertising standardisation have also been observed. Consumers exhibit more favourable attitudes toward foreign-sourced, standardised commercials than their localised cou...
- Published
- 2002
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20. A model of close business relationships in China (guanxi)
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Jae H. Pae, Y.H. Wong, and Dong Jin Lee
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Marketing ,Mainland China ,Empirical research ,media_common.quotation_subject ,Opportunism ,Quality (business) ,Business ,Affect (psychology) ,Guanxi ,Relationship marketing ,Organizational performance ,media_common - Abstract
Examines the antecedents and consequences of close business relationships (guanxi) in China. We hypothesize that decision‐making uncertainty and perceived similarity positively affect guanxi, whereas opportunism negatively affects guanxi. We also hypothesize that guanxi positively affects business performance, mediated by relationship quality and interdependence. An empirical study of Hong Kong and mainland China business relationships generally supports the model. The managerial implications are discussed.
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- 2001
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21. DEVELOPMENT OF DNA MARKERS LINKED TO BACTERIAL LEAF SPOT RESISTANCE OF CHILLI
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B. D. Kim, J.-Y. Yoon, K.-T. Kim, D. H. Pae, H. S. Choi, and H. J. Kim
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Genetics ,education.field_of_study ,Population ,Bulked segregant analysis ,food and beverages ,Xanthomonas campestris pv. Vesicatoria ,Horticulture ,Marker-assisted selection ,Biology ,RAPD ,chemistry.chemical_compound ,chemistry ,Genetic marker ,Molecular marker ,Genotype ,education - Abstract
Bacterial leaf spot disease (Xanthomonas campestris pv. vesicatoria; Xcv) causes severe damage to chilli (Capsicum annuum L.) and has been a major yield constraint. An introduced chilli accession 3-25-27 derived from Florida XVR 3-25 has a dominant gene, Bs2, which confers resistance to Xcv races 1, 2 and 3. To identify RAPD markers linked to Bs2, bulked segregant analysis (BSA) and random amplified polymorphic DNA (RAPD) analysis were performed. Isogenic DNA pools were made from 10 resistant and 10 susceptible plants in a BC 1 F 1 population derived from crosses between 3-25-27 and Early California Wonder. Two RAPD markers, OPD05 and OPF10, were identified from a total of 460 10-basepair primers. From the linkage analysis it was found that two markers were located on either side of the Bs2 gene. OPD05 was located 5.3 cM away from Bs2 gene and OPF10 was located 4.9 cM from the Bs2 on the opposite side to OPD05. For practical use, identified RAPD markers were converted to sequence characterized amplified regions (SCARs). Primer sequences with various lengths were designed and examined for their ability to detect a resistance marker. SCF10, originating from the RAPD marker OPF10, was amplified using a 24-basepair primer set, and it showed polymorphism between resistant and susceptible individuals. The initial SCARs developed from OPD05, however, showed monomorphism between resistant and susceptible plants. After trials with various primer combinations, it was possible to develop a polymorphic SCD05 marker. These markers enable the identification of the Bs2 gene on segregating progenies for marker-assisted selection.
- Published
- 2001
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22. Commitment and vulnerability in B2B relationship selling in the Hong Kong institutional insurance service industry
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Wong, Y.H., Chan, Ricky Y.K., Leung, T.K.P., and Jae H. Pae
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Business-to-business advertising -- Analysis ,Insurance industry -- Customer relations ,Customer loyalty -- Analysis ,Insurance industry ,Advertising, marketing and public relations ,Business - Abstract
A survey of the Hong Kong institutional insurance service industry is conducted to explain the influence of the precursors of the exchange domain on the relationship selling process in business-to-business (B2B) markets. Trust, as well as customization is shown to highly affect vulnerability-based commitment, which in turn is shown to have a significant effect on the loyalty of the customers.
- Published
- 2008
23. Competing multistability in a plasma diode
- Author
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S. J. Hahn and K. H. Pae
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Physics ,business.industry ,Plasma ,Condensed Matter Physics ,Space (mathematics) ,Plasma diodes ,Molecular physics ,Optics ,Plasma instability ,Attractor ,Sensitivity (control systems) ,business ,Multistability ,Diode - Abstract
The competing multistability in a plasma diode system has been demonstrated numerically. This system exhibits the time-dependent, competing behavior between multistable coexisting attractors for the same set of parameters with an extreme sensitivity to the initial conditions. By employing the one-dimensional particle-in-cell simulations, the multistability and the competition between multiple attractors have been investigated in the space of well-defined relevant parameters of a plasma diode system.
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- 2003
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24. Laser-driven electron beam acceleration and future application to compact light sources
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N. Hafz, T. M. Jeong, S. K. Lee, K. H. Pae, J. H. Sung, I. W. Choi, T. J. Yu, Y. U. Jeong, J. Lee, Paul R. Bolton, Hiroyuki Daido, and Sergei V. Bulanov
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Physics ,Waves in plasmas ,business.industry ,Particle accelerator ,Ponderomotive force ,Undulator ,Laser ,Plasma acceleration ,Linear particle accelerator ,Synchrotron ,law.invention ,Optics ,law ,Physics::Accelerator Physics ,Atomic physics ,business - Abstract
Laser‐driven plasma accelerators are gaining much attention by the advanced accelerator community due to the potential these accelerators hold in miniaturizing future high‐energy and medium‐energy machines. In the laser wakefield accelerator (LWFA), the ponderomotive force of an ultrashort high intensity laser pulse excites a longitudinal plasma wave or bubble. Due to huge charge separation, electric fields created in the plasma bubble can be several orders of magnitude higher than those available in conventional microwave and RF‐based accelerator facilities which are limited (up to ∼100 MV/m) by material breakdown. Therefore, if an electron bunch is injected into the bubble in phase with its field, it will gain relativistic energies within an extremely short distance. Here, in the LWFA we show the generation of high‐quality and high‐energy electron beams up to the GeV‐class within a few millimeters of gas‐jet plasmas irradiated by tens of terawatt ultrashort laser pulses. Thus we realize approximately four orders of magnitude acceleration gradients higher than available by conventional technology. As a practical application of the stable high‐energy electron beam generation, we are planning on injecting the electron beams into a few‐meters long conventional undulator in order to realize compact X‐ray synchrotron (immediate) and FEL (future) light sources. Stable laser‐driven electron beam and radiation devices will surely open a new era in science, medicine and technology and will benefit a larger number of users in those fields.
- Published
- 2009
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25. 설화수의 글로벌 전략
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Sang Man Han, Jae H. Pae, and So Young Kim
- Subjects
Microbiology - Published
- 2007
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26. Environmental drivers of circum-Antarctic glacier and ice shelf front retreat over the last two decades
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C. A. Baumhoer, A. J. Dietz, C. Kneisel, H. Paeth, and C. Kuenzer
- Subjects
Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
The safety band of Antarctica, consisting of floating glacier tongues and ice shelves, buttresses ice discharge of the Antarctic Ice Sheet. Recent disintegration events of ice shelves along with glacier retreat indicate a weakening of this important safety band. Predicting calving front retreat is a real challenge due to complex ice dynamics in a data-scarce environment that are unique for each ice shelf and glacier. We explore the extent to which easy-to-access remote sensing and modeling data can help to define environmental conditions leading to calving front retreat. For the first time, we present a circum-Antarctic record of glacier and ice shelf front change over the last two decades in combination with environmental variables such as air temperature, sea ice days, snowmelt, sea surface temperature, and wind direction. We find that the Antarctic Ice Sheet area decreased by −29 618 ± 1193 km2 in extent between 1997–2008 and gained an area of 7108 ± 1029 km2 between 2009 and 2018. Retreat concentrated along the Antarctic Peninsula and West Antarctica including the biggest ice shelves (Ross and Ronne). In several cases, glacier and ice shelf retreat occurred in conjunction with one or several changes in environmental variables. Decreasing sea ice days, intense snowmelt, weakening easterlies, and relative changes in sea surface temperature were identified as enabling factors for retreat. In contrast, relative increases in mean air temperature did not correlate with calving front retreat. For future studies a more appropriate measure for atmospheric forcing should be considered, including above-zero-degree days and temperature extreme events. To better understand drivers of glacier and ice shelf retreat, it is critical to analyze the magnitude of basal melt through the intrusion of warm Circumpolar Deep Water that is driven by strengthening westerlies and to further assess surface hydrology processes such as meltwater ponding, runoff, and lake drainage.
- Published
- 2021
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- View/download PDF
27. Does intra-firm diffusion of innovation lead to inter-firm relationship benefits? The cases of innovation providers and adopters
- Author
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Kim, Namwoon, primary and H. Pae, Jae, primary
- Published
- 2014
- Full Text
- View/download PDF
28. Intergeneration Time Effects
- Author
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Jae H. Pae and Donald R. Lehmann
- Subjects
Marketing ,Economics and Econometrics ,Economics ,Business and International Management - Published
- 2004
- Full Text
- View/download PDF
29. The role of emotion in hi-tech product adoption: the case of WCDMA in Korea
- Author
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Hyun Jung Lee and Jae H. Pae
- Subjects
Marketing ,Phone ,W-CDMA ,Advertising ,Intention to use ,Technology acceptance model ,Product (category theory) ,Psychology ,High tech ,Computer Science Applications - Abstract
The purpose of this study is to examine and extend the technology acceptance model (TAM) to the emotional factor of a customer such as ‘perceived enjoyment’ in hi-technology product adoption. The addition of perceived enjoyment to the traditional TAM with only perceived usefulness and perceived ease-of-use will explain better the use of general hi-technology products that most of us come in contact daily. The model is tested using data of 600 cellular phone users in Korea. This study emphasises that the addition of perceived enjoyment to the traditional TAM with only perceived usefulness and perceived ease-of-use will explain better the use of general hi-technology products that most of us come in contact daily. The result shows that the role of perceived enjoyment is critical to the intention to use a hi-technology product.
- Published
- 2011
- Full Text
- View/download PDF
30. Absolute calibration of a time-of-flight spectrometer and imaging plate for the characterization of laser-accelerated protons
- Author
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Nasr A. M. Hafz, I. W. Choi, Y.-Y. Jin, I. J. Kim, K. H. Pae, Tae Jun Yu, J. H. Sung, S. K. Lee, Chul Min Kim, and J. Lee
- Subjects
Physics ,Spectrometer ,Physics::Instrumentation and Detectors ,business.industry ,Applied Mathematics ,Scintillator ,Laser ,Spectral line ,law.invention ,Time of flight ,Optics ,law ,Measuring instrument ,Calibration ,Physics::Accelerator Physics ,Atomic number ,Nuclear Experiment ,business ,Instrumentation ,Engineering (miscellaneous) - Abstract
A proton energy spectrometer system is composed of a time-of-flight spectrometer (TOFS) and a Thomson parabola spectrometer (TPS), and is used to characterize laser-accelerated protons. The TOFS detects protons with a plastic scintillator, and the TPS with a CR-39 or imaging plate (IP). The two spectrometers can operate simultaneously and give separate time-of-flight (TOF) and Thomson parabola (TP) data. We propose a method to calibrate the TOFS and IP by comparing the TOF data and the TP data taken with CR-39 and IP. The absolute response of the TOFS as a function of proton energy is calculated from the proton number distribution measured with CR-39. The sensitivity of IP to protons is obtained from the proton number distribution estimated with the calibrated TOFS. This method, based on the comparison of the simultaneously measured data, gives more reliable results when using laser-accelerated protons as a calibration source. The calibrated spectrometer system can be used to measure absolutely calibrated energy spectra for the optimization of laser-accelerated protons.
- Published
- 2009
- Full Text
- View/download PDF
31. Proposed hole-target for improving maximum proton energy driven by a short intense laser pulse
- Author
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I. W. Choi, K. H. Pae, S. J. Hahn, J. Lee, and John R. Cary
- Subjects
Physics ,Range (particle radiation) ,Debye sheath ,Proton ,business.industry ,Electron ,Ponderomotive force ,Condensed Matter Physics ,Laser ,Collimated light ,law.invention ,Pulse (physics) ,symbols.namesake ,Optics ,Physics::Plasma Physics ,law ,symbols ,Physics::Accelerator Physics ,Atomic physics ,business - Abstract
By using particle-in-cell simulations, a new method for energetic collimated proton generation via intense short pulse laser-thin foil interactions is presented. To enhance the electron heating efficiency, a small hole is bored at the center of a thin foil target. The small hole combines target heating mechanisms effectively, which results in a high proton maximum energy. While an ultraintense, ultrashort laser pulse propagates through a small hole (diameter
- Published
- 2009
- Full Text
- View/download PDF
32. Diagnostic of laser contrast using target reflectivity
- Author
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K. Markey, M. H. Xu, I. W. Choi, Claes-Göran Wahlström, P. R. Bolton, A. Akutsu, Y. C. Noh, Takashi Kameshima, Soo-Keun Lee, Y. Nakai, Brendan Dromey, Y. T. Li, Masaki Kando, H. Sugiyama, Izuru Daito, I. J. Kim, Akifumi Yogo, Manabu Tanoue, David Neely, C. Spindloe, Akito Sagisaka, K. H. Pae, Hiroyuki Daido, M. Ikegami, Chul Min Kim, S. V. Bulanov, Tomohiro Motomura, S. J. Hawkes, Mamiko Nishiuchi, D. Adams, S. Kondo, Nasr A. M. Hafz, M. Mori, David Carroll, T. M. Jeong, Alexander Robinson, T. Zh. Esirkepov, M. J. V. Streeter, Do-Kyeong Ko, Hiromitsu Kiriyama, S. Orimo, Jae Hee Sung, H. Okada, Tae Jun Yu, Hideo Nagatomo, P. S. Foster, Satyabrata Kar, Matthew Zepf, Takuya Shimomura, J. Lee, Alexander S. Pirozhkov, Koichi Ogura, Paul McKenna, and S. Kanazawa
- Subjects
Physics and Astronomy (miscellaneous) ,Chemistry ,business.industry ,media_common.quotation_subject ,Plasma ,Physical optics ,Breakup ,Laser ,law.invention ,Optics ,law ,Contrast (vision) ,Specular reflection ,Absorption (electromagnetic radiation) ,business ,Beam (structure) ,media_common - Abstract
Using three different laser systems, we demonstrate a convenient and simple plasma based diagnostic of the contrast of high-power short-pulse lasers. The technique is based on measuring the specular reflectivity from a solid target. The reflectivity remains high even at relativistic intensities above 10(19) W/cm(2) in the case of a high-contrast prepulse-free laser. On the contrary, the specular reflectivity drops with increasing intensities in the case of systems with insufficient contrast due to beam breakup and increased absorption caused by preplasma.
- Published
- 2009
- Full Text
- View/download PDF
33. Formation of a Ge-rich layer during the oxidation of strained Si1−xGex
- Author
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Hyo-Suk Kim, K. S. Jun, Mann Ho Cho, T.-W. Lee, Dae Hong Ko, Y. H. Pae, and B. G. Min
- Subjects
chemistry.chemical_compound ,Materials science ,Si substrate ,chemistry ,Diffusion ,Relaxation (NMR) ,Analytical chemistry ,Oxide ,General Physics and Astronomy ,Critical value ,Thermal diffusivity ,Layer (electronics) ,Saturation (magnetic) - Abstract
The diffusion of Ge in Ge-rich layer (GRL) and the factors affecting on it during the oxidation of strained Si1−xGex layers were examined. Strained Si1−xGex layers, having different initial Ge concentrations (x=0.15 and 0.3), were oxidized at 800 and 900°C in a dry O2 ambient for different oxidation times. The diffusion of Ge into the underlying Si1−xGex layer having an initial constant composition and the resulting transformation to GRL were both enhanced with an increase in oxidation temperature. After complete transformation to GRL, GeO2 started to become incorporated into the resulting oxide layer. The formation of GeO2 was initiated by the Ge saturation of the GRL layer with Ge and by the differences in diffusivity of Ge atoms in Si1−xGex and Si substrate. The relaxation occurred when the Ge concentration in the GRL reached a critical value and was not affected by either oxidation time or temperature.
- Published
- 2006
- Full Text
- View/download PDF
34. Self-Oscillation and Chaos in Positive-Bias Plasma Diodes
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H. Pae, K., primary and J. Hahn, S., additional
- Published
- 2002
- Full Text
- View/download PDF
35. Study for Clinical Characteristics of Nontuberculous Mycobacterial Pulmonary Diseases
- Author
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Jung Hie Lee, Choon-Taek Lee, Youngwhan Kim, Young-Soo Shim, Chul-Gyu Yoo, H H Pae, S. K. Han, and Heesun Chung
- Subjects
Pulmonary and Respiratory Medicine ,Drug ,medicine.medical_specialty ,biology ,business.industry ,Incidence (epidemiology) ,Medical record ,media_common.quotation_subject ,Guideline ,Disease ,biology.organism_classification ,Surgery ,Regimen ,Infectious Diseases ,Pharmacotherapy ,Internal medicine ,medicine ,Nontuberculous mycobacteria ,business ,media_common - Abstract
Background: As the prevalence of nontuberculous mycobacteriosis has been increasing rapidly, there has been recent advance in diagnostic methods and drug therapies for disease. Although the incidence of pulmonary disease caused by nontuberculous mycobacteria(NTM) has been increasing in Korea since 1990, detailed clinical description about the disease were very few. In this study we described the clinical manifestations, radiologic findings, and therapeutic outcomes of nontuberculous mycobacterial pulmonary disease. Methods: Medical records and radiologic findings were retrospectively reviewed in 27 patients who were fulfilled the diagnostic criteria of ATS guideline for NTM pulmonary disease between January of 1990 and August of 1998 in Seoul National University Hospital(SNUH). Results: Of the 27 patients, 15 were male. The mean age was 51.5 yr(11.9). Twenty patients(74.1%) had preexisting pulmonary diseases. Among them, 19 patients had previous pulmonary tuberculosis. Sixteen patients(59.2%) had cavitary lesions and the majority showed slow progression over 1 yr during follow up period on radiography. Susceptibility test to standard antituberculous drugs showed 100% resistance to INH, 72.2% to RMP, 81.5% to EMB, 92.6% to PZA. The average resistance rate to 2nd-line antituberculous drugs was 66.1%. Among twenty-one patients(77.8%) who received drug therapy over 6 months, 11 subjects were improved and 10 subjects were aggravated. Of six subjects(22.2%) without therapy, 5 patients were aggravated. Presence of cavity and less than 3 sensitive drugs in the regimen were indicators for adverse outcome. Conclusion : The nontuberculous mycobacterial pulmonary diseases in our hospital developed predominantly in older patients with preexistent pulmonary disease. The results of antituberculous drug therapy has been frustrating and disappointing. To improve treatment response, different susceptibility tests and drug regimens for different species of NTM should be performed. Also, diagnostic and therapeutic guidelines of Korea should be made in the recent future.
- Published
- 1999
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- View/download PDF
36. Utilization of new technologies: organizational adaptation to business environments.
- Author
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Namwoon Kim and Jae H. Pae
- Subjects
TECHNOLOGY management ,TECHNOLOGICAL innovations ,CUSTOMER service management ,SOCIAL aspects of work environments ,CUSTOMER relationship management ,BUSINESS intelligence ,CUSTOMER satisfaction research ,MARKETING management ,MANAGEMENT - Abstract
The practice of introducing new technologies into the corporate environment has become a well-accepted principle for sustaining or advancing competitive advantages. The current study focuses on the environmental and managerial factors associated with the successful utilization of new technologies. To this end, the suggested framework examines the efforts put forth by the two parties involved (the firm buying and the firm supplying the new technology). We use 112 matched data collected from the suppliers and buyers of the customer relationship management (CRM) system in business-to-business markets. We find that the perceived turbulence of business environments stimulates adaptive efforts from both the supplying and buying firms, which may lead to a high level of utilization of new technologies for the buying firm. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
37. A model of close business relationships in China (guanxi).
- Author
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Dong-Jin Lee, Jae H. Pae, and Y.H. Wong
- Subjects
RELATIONSHIP marketing ,BUSINESS enterprises ,DECISION making - Abstract
Examines the antecedents and consequences of close business relationships (guanxi) in China. We hypothesize that decision-making uncertainty and perceived similarity positively affect guanxi, whereas opportunism negatively affects guanxi. We also hypothesize that guanxi positively affects business performance, mediated by relationship quality and interdependence. An empirical study of Hong Kong and mainland China business relationships generally supports the model. The managerial implications are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2001
- Full Text
- View/download PDF
38. The 2007 flood in the Sahel: causes, characteristics and its presentation in the media and FEWS NET
- Author
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C. Samimi, A. H. Fink, and H. Paeth
- Subjects
Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
During the rainy season in 2007, reports about exceptional rains and floodings in the Sahel were published in the media, especially in August and September. Institutions and organizations like the World Food Programme (WFP) and FEWS NET put the events on the agenda and released alerts and requested help. The partly controversial picture was that most of the Sahel faced a crisis caused by widespread floodings. Our study shows that the rainy season in 2007 was exceptional with regard to rainfall amount and return periods. In many areas the event had a return period between 1 and 50 yr with high spatial heterogeneity, with the exception of the Upper Volta basin, which yielded return periods of up to 1200 yr. Despite the strong rainfall, the interpretation of satellite images show that the floods were mainly confined to lakes and river beds. However, the study also proves the difficulties in assessing the meteorological processes and the demarcation of flooded areas in satellite images without ground truthing. These facts and the somewhat vague and controversial reports in the media and FEWS NET demonstrate that it is crucial to thoroughly analyze such events at a regional and local scale involving the local population.
- Published
- 2012
- Full Text
- View/download PDF
39. On the variability of return periods of European winter precipitation extremes over the last three centuries
- Author
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A. Pauling and H. Paeth
- Subjects
Environmental pollution ,TD172-193.5 ,Environmental protection ,TD169-171.8 ,Environmental sciences ,GE1-350 - Abstract
We investigate the changes of extreme European winter (December-February) precipitation back to 1700 and show for various European regions that return periods of extremely wet and dry winters are subject to significant changes both before and after the onset of anthropogenic influences. Generally, winter precipitation has become more extreme. We also examine the spatial pattern of the changes of the extremes covering the last 300 years where data quality is sufficient. Over central and Eastern Europe dry winters occurred more frequently during the 18th and the second part of the 19th century relative to 1951–2000. Dry winters were less frequent during both the 18th and 19th century over the British Isles and the Mediterranean. Wet winters have been less abundant during the last three centuries compared to 1951–2000 except during the early 18th century in central Europe. Although winter precipitation extremes are affected by climate change, no obvious connection of these changes was found to solar, volcanic or anthropogenic forcing. However, physically meaningful interpretation with atmospheric circulation changes was possible.
- Published
- 2007
40. On-Target Contrast Diagnostic via Specular Reflectivity Measurement
- Author
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A. S. Pirozhkov, I. W. Choi, J. H. Sung, S. K. Lee, T. J. Yu, T. M. Jeong, I. J. Kim, N. Hafz, C. M. Kim, K. H. Pae, Y.-C. Noh, D.-K. Ko, J. Lee, A. Robinson, P. Foster, S. Hawkes, M. Streeter, C. Spindloe, P. McKenna, D. C. Carroll, C.-G. Wahlström, M. Zepf, B. Dromey, K. Markey, S. Kar, Y. T. Li, M. H. Xu, H. Nagatomo, M. Mori, A. Yogo, H. Kiriyama, K. Ogura, A. Sagisaka, S. Orimo, M. Nishiuchi, H. Sugiyama, T. Zh. Esirkepov, H. Okada, S. Kondo, S. Kanazawa, Y. Nakai, A. Akutsu, T. Motomura, M. Tanoue, T. Shimomura, M. Ikegami, I. Daito, M. Kando, T. Kameshima, P. Bolton, S. V. Bulanov, H. Daido, D. Neely, Paul R. Bolton, Hiroyuki Daido, and Sergei V. Bulanov
- Subjects
Laser ablation ,Materials science ,business.industry ,media_common.quotation_subject ,Plasma ,Laser ,law.invention ,Optics ,law ,Contrast (vision) ,Optoelectronics ,Plasma diagnostics ,Laser power scaling ,Specular reflection ,Absorption (electromagnetic radiation) ,business ,QC ,media_common - Abstract
High‐power laser contrast is challenging to measure, especially in the real target irradiation conditions. We present a convenient and relatively simple contrast diagnostic technique based on the measurement of target specular reflectivity at full laser power. The reflectivity remains high even at intensities above 1019 W/cm2 in the case of a high‐contrast prepulse‐free laser. On the contrary, the specular reflectivity drops in the case of lower contrast, due to the beam break‐up and increased absorption caused by the preformed plasma. The technique was demonstrated using three different laser systems with several contrast conditions: Astra (CLF, RAL), TiS laser at APRI, GIST, and J‐KAREN (APRC, JAEA).
41. Projection imaging with directional electron and proton beams emitted from an ultrashort intense laser-driven thin foil target.
- Author
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M Nishiuchi, I W Choi, H Daido, T Nakamura, A S Pirozhkov, A Yogo, K Ogura, A Sagisaka, S Orimo, I Daito, S V Bulanov, J H Sung, S K Lee, T J Yu, T M Jeong, I J Kim, C M Kim, S W Kang, K H Pae, and Y Oishi
- Subjects
ELECTRON beams ,PROTON beams ,RADIOGRAPHY ,PUMP probe spectroscopy ,PROTON accelerators - Abstract
Projection images of a metal mesh produced by directional MeV electron beam together with directional proton beam, emitted simultaneously from a thin foil target irradiated by an ultrashort intense laser, are recorded on an imaging plate for the electron imaging and on a CR-39 nuclear track detector for the proton imaging. The directional electron beam means the portion of the electron beam which is emitted along the same direction (i.e., target normal direction) as the proton beam. The mesh patterns are projected to each detector by the electron beam and the proton beam originated from tiny virtual sources of ~20 µm and ~10 µm diameters, respectively. Based on the observed quality and magnification of the projection images, we estimate sizes and locations of the virtual sources for both beams and characterize their directionalities. To carry out physical interpretation of the directional electron beam qualitatively, we perform 2D particle-in-cell simulation which reproduces a directional escaping electron component, together with a non-directional dragged-back electron component, the latter mainly contributes to building a sheath electric field for proton acceleration. The experimental and simulation results reveal various possible applications of the simultaneous, synchronized electron and proton sources to radiography and pump-probe measurements with temporal resolution of ~ps and spatial resolution of a few tens of µm. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
42. Drosophila require both green and UV wavelengths for sun orientation but lack a time-compensated sun compass.
- Author
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Pae H, Liao J, Yuen N, and Giraldo YM
- Subjects
- Animals, Flight, Animal physiology, Sunlight, Female, Orientation physiology, Male, Drosophila melanogaster physiology, Ultraviolet Rays, Cues, Orientation, Spatial
- Abstract
Celestial orientation and navigation are performed by many organisms in contexts as diverse as migration, nest finding and straight-line orientation. The vinegar fly, Drosophila melanogaster, performs menotaxis in response to celestial cues during tethered flight and can disperse more than 10 km under field conditions. However, we still do not understand how spectral components of celestial cues and pauses in flight impact heading direction in flies. To assess individual heading, we began by testing flies in a rotating tether arena using a single green LED as a stimulus. We found that flies robustly perform menotaxis and fly straight for at least 20 min. Flies maintain their preferred heading directions after experiencing a period of darkness or stopping flight, even up to 2 h, but reset their heading when the LED changes position, suggesting that flies do not treat this stimulus as the sun. Next, we assessed the flies' responses to a UV spot alone or a paired UV-green stimulus - two dots situated 180 deg apart to simulate the solar and antisolar hemispheres. We found that flies respond to UV much as they do to green light; however, when the stimuli are paired, flies adjust for sudden 90 deg movements, performing sun orientation. Lastly, we found no evidence of a time-compensated sun compass when we moved the paired stimuli at 15 deg h-1 for 6 h. This study demonstrates that wavelength influences how flies respond to visual cues during flight, shaping the interpretation of visual information to execute an appropriate behavioral response., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2024. Published by The Company of Biologists Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
43. Three-Dimensional Printing of an Apigenin-Loaded Mucoadhesive Film for Tailored Therapy to Oral Leukoplakia and the Chemopreventive Effect on a Rat Model of Oral Carcinogenesis.
- Author
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Takashima H, Tagami T, Kato S, Pae H, Ozeki T, and Shibuya Y
- Abstract
Oral leukoplakia, which presents as white lesions in the oral cavity, including on the tongue, is precancerous in nature. Conservative treatment is preferable, since surgical removal can markedly reduce the patient's quality of life. In the present study, we focused on the flavonoid apigenin as a potential compound for preventing carcinogenesis, and an apigenin-loaded mucoadhesive oral film was prepared using a three-dimensional (3D) bioprinter (semi-solid extrusion-type 3D printer). Apigenin-loaded printer inks are composed of pharmaceutical excipients (HPMC, CARBOPOL, and Poloxamer), water, and ethanol to dissolve apigenin, and the appropriate viscosity of printer ink after adjusting the ratios allowed for the successful 3D printing of the film. After drying the 3D-printed object, the resulting film was characterized. The chemopreventive effect of the apigenin-loaded film was evaluated using an experimental rat model that had been exposed to 4-nitroquinoline 1-oxide (4NQO) to induce oral carcinogenesis. Treatment with the apigenin-loaded film showed a remarkable chemopreventive effect based on an analysis of the specimen by immunohistostaining. These results suggest that the apigenin-loaded mucoadhesive film may help prevent carcinogenesis. This successful preparation of apigenin-loaded films by a 3D printer provides useful information for automatically fabricating other tailored films (with individual doses and shapes) for patients with oral leukoplakia in a future clinical setting.
- Published
- 2022
- Full Text
- View/download PDF
44. Parahippocampal latrophilin-2 (ADGRL2) expression controls topographical presubiculum to entorhinal cortex circuit connectivity.
- Author
-
Donohue JD, Amidon RF, Murphy TR, Wong AJ, Liu ED, Saab L, King AJ, Pae H, Ajayi MT, and Anderson GR
- Subjects
- Animals, Entorhinal Cortex metabolism, Female, Gene Expression genetics, Gene Expression Regulation genetics, Hippocampus physiology, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Neural Pathways cytology, Neurons physiology, Parahippocampal Gyrus metabolism, Receptors, Peptide metabolism, Entorhinal Cortex physiology, Receptors, Peptide genetics
- Abstract
Brain circuits are comprised of distinct interconnected neurons that are assembled by synaptic recognition molecules presented by defined pre- and post-synaptic neurons. This cell-cell recognition process is mediated by varying cellular adhesion molecules, including the latrophilin family of adhesion G-protein-coupled receptors. Focusing on parahippocampal circuitry, we find that latrophilin-2 (Lphn2; gene symbol ADGRL2) is specifically enriched in interconnected subregions of the medial entorhinal cortex (MEC), presubiculum (PrS), and parasubiculum (PaS). Retrograde viral tracing from the Lphn2-enriched region of the MEC reveals unique topographical patterning of inputs arising from the PrS and PaS that mirrors Lphn2 expression. Using a Lphn2 conditional knockout mouse model, we find that deletion of MEC Lphn2 expression selectively impairs retrograde viral labeling of inputs arising from the ipsilateral PrS. Combined with analysis of Lphn2 expression within the MEC, this study reveals Lphn2 to be selectively expressed by defined cell types and essential for MEC-PrS circuit connectivity., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
45. Construct Validity and Measurement Invariance of the Peabody Picture Vocabulary Test-III Form A in the Performance of Struggling Adult Readers: Rasch Modeling.
- Author
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Pae H, Greenberg D, and Morris RD
- Abstract
PURPOSE: The aim of this study was to apply the Rasch model to an analysis of the psychometric properties of the PPVT-III Form A items with struggling adult readers. METHODS: The PPVT-IIIA was administered to 229 African-American adults whose isolated word reading skills were between third and fifth grades. Conformity of the adults' performance on the PPVT-III items was evaluated using the Winsteps software. RESULTS: Analysis of all PPVT-IIIA items combined did not fully support its use as a useful measure of receptive vocabulary for struggling adult readers who were African Americans. To achieve an adequate model fit, items 73 through item 156 were analyzed. The items analyzed showed adequate internal consistency reliability, unidimensionality, and freedom from differential item functioning for ability, gender, and age, with a minor modification. DISCUSSION: With an appropriate treatment of misfit items, the results supported the measurement properties, internal consistency reliability, unidimensionality of the PPVT-IIIA items, and measurement invariance of the test across subgroups of ability, age, and gender.
- Published
- 2012
- Full Text
- View/download PDF
46. [Case of occupational autoimmune alveolar pneumonia].
- Author
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Dun GX, Liu LX, Zhu JW, Pae H, He JG, and Cen L
- Subjects
- Alveolitis, Extrinsic Allergic therapy, Humans, Occupational Diseases therapy, Alveolitis, Extrinsic Allergic diagnosis, Occupational Diseases diagnosis
- Published
- 2003
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