130 results on '"H. Niessen"'
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2. Saturday, 17 July 2010
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I. Dimova, R. Hlushchuk, A. Makanya, V. Djonov, M. Theurl, W. Schgoer, K. Albrecht, A. Beer, J. R. Patsch, P. Schratzberger, S. Mahata, R. Kirchmair, M. Didie, P. Christalla, T. Rau, T. Eschenhagen, U. Schumacher, Q. Lin, M. Zenke, W. Zimmmermann, M. Hoch, P. Fischer, B. Stapel, E. Missol-Kolka, S. Erschow, M. Scherr, H. Drexler, D. Hilfiker-Kleiner, I. Diebold, A. Petry, P. Kennel, T. Djordjevic, J. Hess, A. Goerlach, J. Castellano, R. Aledo, J. Sendra, P. Costales, L. Badimon, V. Llorente-Cortes, E. Dworatzek, S. Mahmoodzadeh, V. Regitz-Zagrosek, A. Posa, C. Varga, A. Berko, M. Veszelka, P. Szablics, B. Vari, I. Pavo, F. Laszlo, M. Brandenburger, J. Wenzel, R. Bogdan, D. Richardt, M. Reppel, J. Hescheler, H. Terlau, A. Dendorfer, J. Heijman, Y. Rudy, R. Westra, P. Volders, R. Rasmusson, V. Bondarenko, M. D. Ertas Gokhan, M. D. Ural Ertan, P. H. D. Karaoz Erdal, P. H. D. Aksoy Ayca, M. D. Kilic Teoman, M. D. Kozdag Guliz, M. D. Vural Ahmet, M. D. Ural Dilek, C. Poulet, T. Christ, E. Wettwer, U. Ravens, C. Van Der Pouw Kraan, S. Schirmer, J. Fledderus, P. Moerland, T. Leyen, J. Piek, N. Van Royen, A. Horrevoets, F. Fleissner, V. Jazbutyte, J. Fiedler, P. Galuppo, M. Mayr, G. Ertl, J. Bauersachs, T. Thum, S. Protze, A. Bussek, F. Li, R. Hoo, K. Lam, A. Xu, P. Subramanian, E. Karshovska, R. Megens, S. Akhtar, K. Heyll, Y. Jansen, C. Weber, A. Schober, M. Zafeiriou, C. Noack, A. Renger, R. Dietz, L. Zelarayan, M. Bergmann, I. Meln, A. Malashicheva, S. Anisimov, N. Kalinina, V. Sysoeva, A. Zaritskey, A. Barbuti, A. Scavone, N. Mazzocchi, A. Crespi, D. Capilupo, D. Difrancesco, L. Qian, W. Shim, Y. Gu, S. Mohammed, P. Wong, M. Zafiriou, H. Schaeffer, P. Kovacs, J. Simon, A. Varro, P. Athias, J. Wolf, O. Bouchot, D. Vandroux, A. Mathe, A. De Carvalho, G. Laurent, P. Rainer, M. Huber, F. Edelmann, T. Stojakovic, A. Trantina-Yates, M. Trauner, B. Pieske, D. Von Lewinski, A. De Jong, A. Maass, S. Oberdorf-Maass, I. Van Gelder, Y. Lin, J. Li, F. Wang, Y. He, X. Li, H. Xu, X. Yang, R. Coppini, C. Ferrantini, C. Ferrara, A. Rossi, A. Mugelli, C. Poggesi, E. Cerbai, N. Rozmaritsa, N. Voigt, D. Dobrev, M.-C. Kienitz, G. Zoidl, K. Bender, L. Pott, Z. Kohajda, A. Kristof, L. Virag, N. Jost, A. Trafford, B. Prnjavorac, E. Mujaric, J. Jukic, K. Abduzaimovic, K. Brack, V. Patel, J. Coote, G. Ng, R. Wilders, A. Van Ginneken, A. Verkerk, P. Xaplanteris, C. Vlachopoulos, K. Baou, C. Vassiliadou, I. Dima, N. Ioakeimidis, C. Stefanadis, W. Ruifrok, C. Qian, H. Sillje, H. Van Goor, D. Van Veldhuisen, W. Van Gilst, R. De Boer, K. Schmidt, F. Kaiser, J. Erdmann, C. De Wit, O. Barnett, Y. Kyyak, F. Cesana, L. Boffi, T. Mauri, M. Alloni, M. Betelli, S. Nava, C. Giannattasio, G. Mancia, R. Vilskersts, J. Kuka, B. Svalbe, E. Liepinsh, M. Dambrova, A. Zakrzewicz, J. Maroski, B. Vorderwuelbecke, K. Fiedorowicz, L. Da Silva-Azevedo, A. Pries, B. Gryglewska, M. Necki, M. Zelawski, T. Grodzicki, E. Scoditti, M. Massaro, M. Carluccio, A. Distante, C. Storelli, R. De Caterina, O. Kocgirli, S. Valcaccia, V. Dao, T. Suvorava, S. Kumpf, M. Floeren, M. Oppermann, G. Kojda, C. Leo, J. Ziogas, J. Favaloro, O. Woodman, W. Goettsch, A. Marton, C. Goettsch, H. Morawietz, E. Khalifa, Z. Ashour, V. Rupprecht, F. Scalera, J. Martens-Lobenhoffer, S. Bode-Boeger, W. Li, Y. Kwan, G. Leung, F. Patella, A. Mercatanti, L. Pitto, G. Rainaldi, I. Tsimafeyeu, Y. Tishova, N. Wynn, S. Kalinchenko, M. Clemente Lorenzo, M. Grande, F. Barriocanal, M. Aparicio, A. Martin, J. Hernandez, J. Lopez Novoa, C. Martin Luengo, A. Kurlianskaya, T. Denisevich, N. Barth, A. Loot, I. Fleming, Y. Wang, A. Gabrielsen, R. Ripa, E. Jorgensen, J. Kastrup, G. Arderiu, E. Pena, K. Kobus, J. Czyszek, A. Kozlowska-Wiechowska, P. Milkiewicz, M. Milkiewicz, R. Madonna, E. Montebello, Y. Geng, J. Chin-Dusting, D. Michell, M. Skilton, J. Dixon, A. Dart, X. Moore, M. Ehrbar, P. Reichmuth, N. Heinimann, B. Hewing, V. Stangl, K. Stangl, M. Laule, G. Baumann, A. Ludwig, R. Widmer-Teske, A. Mueller, P. Stieger, H. Tillmanns, R. Braun-Dullaeus, D. Sedding, K. Troidl, L. Eller, I. Benli, H. Apfelbeck, W. Schierling, C. Troidl, W. Schaper, T. Schmitz-Rixen, R. Hinkel, T. Trenkwalder, A. Pfosser, F. Globisch, G. Stachel, C. Lebherz, I. Bock-Marquette, C. Kupatt, C. Seyler, E. Duthil-Straub, E. Zitron, E. Scholz, D. Thomas, J. Gierten, C. Karle, R. Fink, T. Padro, R. Lugano, M. Garcia-Arguinzonis, M. Schuchardt, J. Pruefer, M. Toelle, N. Pruefer, V. Jankowski, J. Jankowski, W. Zidek, M. Van Der Giet, P. Fransen, C. Van Hove, C. Michiels, J. Van Langen, H. Bult, R. Quarck, M. Wynants, E. Alfaro-Moreno, M. Rosario Sepulveda, F. Wuytack, D. Van Raemdonck, B. Meyns, M. Delcroix, F. Christofi, S. Wijetunge, P. Sever, A. Hughes, J. Ohanian, S. Forman, V. Ohanian, C. Gibbons, S. Vernia, A. Das, V. Shah, M. Casado, W. Bielenberg, J. Daniel, J.-M. Daniel, K. Hersemeyer, T. Schmidt-Woell, D. Kaetzel, H. Tillmans, S. Kanse, E. Tuncay, H. Kandilci, E. Zeydanli, N. Sozmen, D. Akman, S. Yildirim, B. Turan, N. Nagy, K. Acsai, A. Farkas, J. Papp, A. Toth, C. Viero, S. Mason, A. Williams, S. Marston, D. Stuckey, E. Dyer, W. Song, M. El Kadri, G. Hart, M. Hussain, A. Faltinova, J. Gaburjakova, L. Urbanikova, M. Hajduk, B. Tomaskova, M. Antalik, A. Zahradnikova, P. Steinwascher, K. Jaquet, A. Muegge, G. Wang, M. Zhang, C. Tesi, H. Ter Keurs, S. Kettlewell, G. Smith, A. Workman, I. Lenaerts, P. Holemans, S. Sokolow, S. Schurmans, A. Herchuelz, K. Sipido, G. Antoons, X. Wehrens, N. Li, J. R. Respress, A. De Almeida, R. Van Oort, H. Lohmann, M. Saes, A. Messer, O. Copeland, M. Leung, F. Matthes, J. Steinbrecher, G. Salinas-Riester, L. Opitz, G. Hasenfuss, S. Lehnart, G. Caracciolo, M. Eleid, S. Carerj, K. Chandrasekaran, B. Khandheria, P. Sengupta, I. Riaz, L. Tyng, Y. Dou, A. Seymour, C. Dyer, S. Griffin, S. Haswell, J. Greenman, S. Yasushige, P. Amorim, T. Nguyen, M. Schwarzer, F. Mohr, T. Doenst, S. Popin Sanja, D. Lalosevic, I. Capo, T. Momcilov Popin, A. Astvatsatryan, M. Senan, G. Shafieian, N. Goncalves, I. Falcao-Pires, T. Henriques-Coelho, D. Moreira-Goncalves, A. Leite-Moreira, L. Bronze Carvalho, J. Azevedo, M. Andrade, I. Arroja, M. Relvas, G. Morais, M. Seabra, A. Aleixo, J. Winter, M. Zabunova, I. Mintale, D. Lurina, I. Narbute, I. Zakke, A. Erglis, Z. Marcinkevics, S. Kusnere, A. Abolins, J. Aivars, U. Rubins, Y. Nassar, D. Monsef, G. Hamed, S. Abdelshafy, L. Chen, Y. Wu, J. Wang, C. Cheng, M. Sternak, T. Khomich, A. Jakubowski, M. Szafarz, W. Szczepanski, L. Mateuszuk, J. Szymura-Oleksiak, S. Chlopicki, J. Sulicka, M. Strach, I. Kierzkowska, A. Surdacki, T. Mikolajczyk, W. Balwierz, T. Guzik, V. Dmitriev, E. Oschepkova, O. Polovitkina, V. Titov, A. Rogoza, R. Shakur, S. Metcalfe, J. Bradley, S. Demyanets, C. Kaun, S. Kastl, S. Pfaffenberger, I. Huk, G. Maurer, K. Huber, J. Wojta, O. Eriksson, M. Aberg, A. Siegbahn, G. Niccoli, G. Sgueglia, M. Conte, S. Giubilato, N. Cosentino, G. Ferrante, F. Crea, D. Ilisei, M. Leon, F. Mitu, E. Kyriakakis, M. Philippova, M. Cavallari, V. Bochkov, B. Biedermann, G. De Libero, P. Erne, T. Resink, C. Bakogiannis, C. Antoniades, D. Tousoulis, M. Demosthenous, C. Psarros, N. Sfyras, K. Channon, S. Del Turco, T. Navarra, G. Basta, V. Carnicelli, S. Frascarelli, R. Zucchi, A. Kostareva, G. Sjoberg, A. Gudkova, E. Semernin, E. Shlyakhto, T. Sejersen, N. Cucu, M. Anton, D. Stambuli, A. Botezatu, C. Arsene, E. Lupeanu, G. Anton, J. Patsch, E. Huber, C. Lande, A. Cecchettini, L. Tedeschi, M. Trivella, L. Citti, B. Chen, Y. Ma, Y. Yang, X. Ma, F. Liu, M. Hasanzad, L. Rejali, M. Fathi, A. Minassian, R. Mohammad Hassani, A. Najafi, M. Sarzaeem, S. Sezavar, A. Akhmedov, R. Klingenberg, K. Yonekawa, C. Lohmann, S. Gay, W. Maier, M. Neithard, T. Luescher, X. Xie, Z. Fu, A. Kevorkov, L. Verduci, F. Cremisi, A. Wonnerth, K. Katsaros, G. Zorn, T. Weiss, R. De Rosa, G. Galasso, F. Piscione, G. Santulli, G. Iaccarino, R. Piccolo, R. Luciano, M. Chiariello, M. Szymanski, R. Schoemaker, H. Hillege, S. Rizzo, C. Basso, G. Thiene, M. Valente, S. Rickelt, W. Franke, G. Bartoloni, S. Bianca, E. Giurato, C. Barone, G. Ettore, I. Bianca, P. Eftekhari, G. Wallukat, A. Bekel, F. Heinrich, M. Fu, M. Briedert, J. Briand, J. Roegel, K. Pilichou, S. Korkmaz, T. Radovits, S. Pali, K. Hirschberg, S. Zoellner, S. Loganathan, M. Karck, G. Szabo, A. Pucci, J. Pantaleo, S. Martino, G. Pelosi, M. Matteucci, C. Kusmic, N. Vesentini, F. Piccolomini, F. Viglione, A. L'abbate, J. Slavikova, M. Chottova Dvorakova, W. Kummer, A. Campanile, L. Spinelli, M. Ciccarelli, S. De Gennaro, E. Assante Di Panzillo, B. Trimarco, R. Akbarzadeh Najar, S. Ghaderian, A. Tabatabaei Panah, H. Vakili, A. Rezaei Farimani, G. Rezaie, A. Beigi Harchegani, N. Hamdani, C. Gavina, J. Van Der Velden, H. Niessen, G. Stienen, W. Paulus, C. Moura, I. Lamego, C. Eloy, J. Areias, T. Bonda, M. Dziemidowicz, T. Hirnle, I. Dmitruk, K. Kaminski, W. Musial, M. Winnicka, A. Villar, D. Merino, M. Ares, F. Pilar, E. Valdizan, M. Hurle, J. Nistal, V. Vera, P. Karuppasamy, S. Chaubey, T. Dew, R. Sherwood, J. Desai, L. John, M. Marber, G. Kunst, E. Cipolletta, A. Attanasio, C. Del Giudice, P. Campiglia, M. Illario, A. Berezin, E. Koretskaya, E. Bishop, I. Fearon, J. Heger, B. Warga, Y. Abdallah, B. Meyering, K. Schlueter, H. Piper, G. Euler, A. Lavorgna, S. Cecchetti, T. Rio, G. Coluzzi, C. Carrozza, E. Conti, F. Andreotti, A. Glavatskiy, O. Uz, E. Kardesoglu, O. Yiginer, S. Bas, O. Ipcioglu, N. Ozmen, M. Aparci, B. Cingozbay, F. Ivanes, M. Hillaert, S. Susen, F. Mouquet, P. Doevendans, B. Jude, G. Montalescot, E. Van Belle, C. Castellani, A. Angelini, O. De Boer, C. Van Der Loos, G. Gerosa, A. Van Der Wal, I. Dumitriu, P. Baruah, J. Kaski, O. Maytham, J. D Smith, M. Rose, A. Cappelletti, A. Pessina, M. Mazzavillani, G. Calori, A. Margonato, S. Cassese, C. D'anna, A. Leo, A. Silenzi, M. Baca', L. Biasucci, D. Baller, U. Gleichmann, J. Holzinger, T. Bitter, D. Horstkotte, A. Antonopoulos, A. Miliou, C. Triantafyllou, W. Masson, D. Siniawski, P. Sorroche, L. Casanas, W. Scordo, J. Krauss, A. Cagide, T. Huang, A. Wiedon, S. Lee, K. Walker, K. O'dea, P. Perez Berbel, V. Arrarte Esteban, M. Garcia Valentin, M. Sola Villalpando, C. Lopez Vaquero, L. Caballero, M. Quintanilla Tello, F. Sogorb Garri, G. Duerr, N. Elhafi, T. Bostani, L. Swieny, E. Kolobara, A. Welz, W. Roell, O. Dewald, N. Kaludercic, E. Takimoto, T. Nagayama, K. Chen, J. Shih, D. Kass, F. Di Lisa, N. Paolocci, L. Vinet, M. Pezet, F. Briec, M. Previlon, P. Rouet-Benzineb, A. Hivonnait, F. Charpentier, J. Mercadier, M. Cobo, M. Llano, C. Montalvo, V. Exposito, L. Meems, B. Westenbrink, L. Biesmans, V. Bito, R. Driessen, C. Huysmans, I. Mourouzis, C. Pantos, G. Galanopoulos, M. Gavra, P. Perimenis, D. Spanou, D. Cokkinos, T. Panasenko, S. Partsch, C. Harjung, A. Bogdanova, D. Mihov, P. Mocharla, S. Yakushev, J. Vogel, M. Gassmann, R. Tavakoli, D. Johansen, E. Sanden, C. Xi, R. Sundset, K. Ytrehus, M. Bliksoen, A. Rutkovskiy, L. Mariero, I. Vaage, K. Stenslokken, O. Pisarenko, V. Shulzhenko, I. Studneva, L. Serebryakova, O. Tskitishvili, Y. Pelogeykina, A. Timoshin, A. Vanin, L. Ziberna, M. Lunder, G. Drevensek, S. Passamonti, L. Gorza, B. Ravara, C. Scapin, M. Vitadello, F. Zigrino, J. Gwathmey, F. Del Monte, G. Vilahur, O. Juan-Babot, B. Onate, L. Casani, S. Lemoine, G. Calmettes, B. Jaspard-Vinassa, C. Duplaa, T. Couffinhal, P. Diolez, P. Dos Santos, A. Fusco, D. Sorriento, P. Cervero, A. Feliciello, E. Barnucz, K. Kozichova, M. Hlavackova, J. Neckar, F. Kolar, O. Novakova, F. Novak, C. Barsanti, N. Abraham, D. Muntean, S. Mirica, O. Duicu, A. Raducan, M. Hancu, O. Fira-Mladinescu, V. Ordodi, J. Voelkl, B. Haubner, G. Neely, C. Moriell, S. Seidl, O. Pachinger, J. Penninger, and B. Metzler
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Physiology ,Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2010
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3. Unusual Sites of Metastatic Involvement
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M.R.M. Jongbloed, R.J.L.F. Loffeld, B.L.J. Kanen, M.J. Flens, M. Visser, and H. Niessen
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Cancer Research ,Pathology ,medicine.medical_specialty ,Fatal outcome ,business.industry ,Merkel cell carcinoma ,medicine.disease ,Intracardiac injection ,Metastasis ,medicine.anatomical_structure ,Oncology ,Carcinoma ,Medicine ,business ,Merkel cell ,Heart atrium - Published
- 2004
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4. Nuclear imaging to support anti-inflammatory drug discovery and development
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A, Wunder, A, Thiele, M, Koslowski, F, Gantner, and H, Niessen
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Inflammation ,Treatment Outcome ,Drug Design ,Isotope Labeling ,Outcome Assessment, Health Care ,Anti-Inflammatory Agents ,Animals ,Humans ,Radiopharmaceuticals ,Tomography, Emission-Computed - Abstract
Nuclear medicine contributes important tools to support antiinflammatory drug discovery and development in many ways. The support provided is manifold: new molecular entities (NME, either small molecules or biologics) labeled with radioisotopes can be applied in animal models and humans to measure biodistribution, target engagement, and pharmacokinetics. In addition, nuclear imaging techniques can be used to select or enrich the patient populations in clinical trials, to assess disease activity, target status and distribution and to quantify response to therapeutic interventions. In the first part of this review we will outline how nuclear imaging techniques can be applied to support informed decision making in drug development. In the second part, we will briefly highlight the use of nuclear imaging of inflammation in drug development in selected diseases, specifically rheumatoid arthritis (RA), inflammatory bowel diseases (IBD), atherosclerosis (ATS) and as an emerging topic cancer.
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- 2014
5. Altbekannte Schadstoffe und neuentdeckte Toxaphene im Fettgewebe von Kindern
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H. M. Helbich, J. Sartoris, K. Witt, I. Böhn, W. Müller, M. Teufel, and K. H. Niessen
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Gynecology ,medicine.medical_specialty ,Camphechlor ,business.industry ,Pediatrics, Perinatology and Child Health ,medicine ,Follow up studies ,Surgery ,business - Abstract
Fragestellung: Wie haben sich die Konzentrationen der Chlorkohlenwasserstoffe (CKW) im Fettgewebe von Kindern wahrend der letzten 14 Jahre verhalten? Sind noch andere als die bisher bekannten Schadstoffe im Fett abgelagert? Methode: In Fettgewebsproben von 1267 Sauglingen, Kindern und Adoleszenten aus West- und Ostdeutschland sowie aus Saratow, Rusland, wurden die Konzentrationen der CKW mittels Gaschromatographie bzw. Massenspektrometrie quantitativ bestimmt und auf den Fettgehalt bezogen angegeben (µg/kg Fett=ppb). Ergebnisse: Die Konzentrationen der bisher bekannten CKW sind wahrend der letzten Jahre alle stark zuruckgegangen. Es wurden aber auch bisher unbekannte CKW im Fettgewebe entdeckt, namlich 2 Toxaphene (Parlar 26 und 50) in geringer Menge. Schlusfolgerung: Zwar ist die Belastung unserer Kinder mit den bisher bekannten CKW wahrend der letzten Jahre deutlich zuruckgegangen, doch fuhrten empfindlichere Nachweismethoden zum Nachweis bisher unbekannter potentieller Schadstoffe im Fettgewebe, so das eine vollige Entwarnung z.Z. noch nicht gerechtfertigt ist.
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- 1998
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6. Integration of bioaccumulation in an environmental risk assessment
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W. de Wolf, Mike Comber, H. Niessen, K. den Haan, Pamela J. Kloepper-Sams, R. Heusel, R. van Egmond, Tom C. J. Feijtel, A. Gard, P. Wierich, and W.F. ten Berge
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Environmental engineering ,Biota ,General Medicine ,General Chemistry ,Pollution ,Aquatic environment ,Bioaccumulation ,Environmental chemistry ,Toxicity ,Environmental Chemistry ,%22">Fish ,Environmental science ,Organism ,Environmental risk assessment - Abstract
The potential of a substance to bioaccumulate in the aquatic environment into an organism depends particularly on its lipophilicity and its metabolism within the organism. Bioaccumulation is an exposure-related parameter and will determine the body burden but it is not an ‘effect’ or hazard in itself. Therefore, when appropriate, bioaccumulation should be included as an exposure related parameter in the environmental risk assessment of substances. The “direct” toxicity assessment should consider “time to steady state” in evaluating PNEC values. Depending on the steady-state criteria used, the duration of a 96h acute fish LC50 test may be insufficient for substances with a log Kow above the range of 3.8–4.5. If exposure and uptake are possible, the BCF is estimated in an iterative approach in order to address the potential for bioaccumulation and resultant “indirect” (dietary) toxicity. When the BCF value is above 1000, a PEC/PNEC assessment for predators is made. A step-wise approach is recommended. In practice, substances which are widely dispersed in the environment, which potentially can be taken up by biota, which are persistent, lipophilic and exhibit negligible metabolism will be selected by this scheme for a more detailed evaluation.
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- 1997
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7. Development of a geography-referenced regional exposure assessment tool for European rivers - great-er contribution to great-er #1
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Volker Koch, Diederik Schowanek, G. Morris, Michael Matthies, M. Holt, Tom C. J. Feijtel, Claudio Gandolfi, G. Cassani, R. Schroder, J. Rosenblom, K Fox, B. Hansen, Geert Boeije, H. Niessen, and A. Young
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Environmental Engineering ,Geographic information system ,Data collection ,business.industry ,Health, Toxicology and Mutagenesis ,Scale (chemistry) ,Environmental resource management ,Public Health, Environmental and Occupational Health ,Environmental engineering ,General Medicine ,General Chemistry ,Pollution ,Risk analysis (business) ,Environmental Chemistry ,Software system ,Catchment area ,Water quality ,business ,Exposure assessment - Abstract
The objective of the GREAT-ER project is to develop and validate a powerful and accurate aquatic chemical exposure prediction tool for use within the EU environmental risk assessment schemes. Current techniques to estimate regional predicted environmental concentrations (PECs) use a generic multimedia ‘unit world’ approach and do not account for spatial and temporal variability in landscape characteristics, river flows and/or chemical emissions. Hence, the results are merely applicable on a generic screening level since these models do not offer a realistic prediction of actual steady-state background concentrations. A software system will be developed to calculate the distribution of predicted environmental concentrations (PECs) of down-the-drain chemicals in European surface waters on both a river and catchment area level. Data on dissolved oxygen, biological oxygen demand and ammonia will also be used to assess water quality and to provide data for calibration and verification. The system will use a Geographic Information System (GIS) for data storage and visualization, combined with simple mathematical models for the prediction of chemical fate. Hydrological databases and models will be used to determine river flows. This refined exposure assessment tool should significantly enhance the accuracy of current local and regional exposure estimation methods. The new exposure assessment methodology will integrate specific environmental information and be worked out in a geographically-referenced framework, ultimately on a pan-European scale. The initial data collection, collation and model application will be applied to two pilot study areas, representative of different hydrological and climatological situations in Europe. A blueprint of the methodology will be developed and applied to these pilot study areas, which will allow refining, optimization and verification of the system.The ultimate objective is to implement GREAT-ER for the entire European Union.This work will be performed in the second phase of the project, after the initial three years which are limited to the development of the methodology and verification in the pilot study areas.
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- 1997
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8. European Union System for the Evaluation of Substances (EUSES). Principles and structure
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D.T. Jager, P.T.J. van der Zandt, H. Niessen, Bernd M. Bussian, J. Devillers, Björn Hansen, S. Robertson, Theo Vermeire, Henrik Tyle, I. Lundberg, and K. den Haan
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Risk analysis ,Engineering ,Environmental Engineering ,International Cooperation ,Health, Toxicology and Mutagenesis ,Food Contamination ,Guidelines as Topic ,Risk Assessment ,Hazardous Substances ,Environmental protection ,Occupational Exposure ,Animals ,Humans ,Soil Pollutants ,Environmental Chemistry ,media_common.cataloged_instance ,Water Pollutants ,European Union ,European union ,Environmental planning ,Exposure assessment ,media_common ,Dose-Response Relationship, Drug ,business.industry ,Member states ,Public Health, Environmental and Occupational Health ,Guidance documents ,Environmental Exposure ,General Medicine ,General Chemistry ,Environmental exposure ,Directive ,Pollution ,Risk assessment ,business ,Environmental Health ,Software - Abstract
In the European Union, Directive 92/32/EC and EC Council Regulation (EC) 793/93 require the risk assessment of new and existing substances, respectively. Principles for this risk assessment have been laid down, supported by a detailed package of Technical Guidance Documents. Against this background the European Union System for the Evaluation of Substances (EUSES) has been developed. This software can be used to carry out tiered risk assessments of increasing complexity on the basis of increasing data requirements. The exposure assessment, effects assessment and risk characterisation are carried out for environmental populations as well as for human beings, including workers, consumers and man exposed through the environment. EUSES is the result of a co-ordinated effort of EU Member States, the European Commission and the European Chemical Industry.
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- 1997
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9. Validierung eines kindgerechten 13 C-Harnstoff-Atemtests zur Helicobacter-pylori-Diagnostik
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K. H. Niessen, I. Böhn, and M. Teich
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Gynecology ,medicine.medical_specialty ,business.industry ,Medical screening ,Pediatrics, Perinatology and Child Health ,medicine ,Surgery ,business - Abstract
Fragestellung: Das Ziel der Studie war die Validierung einer kindgerechten Modifikation des bei Erwachsenen angewandten 13C-Harnstoff-Atemtests zur Diagnose einer Helicobacter-pylori-Infektion. Methode: Bei 30 asymptomatischen Kindern wurden die Ergebnisse des Atemtests mit dem eines Helicobacter-pylori-ELISA-Tests verglichen. Bei 10 symptomatischen Kindern konnte das Atemtestergebnis mit einem histologischen Befund der Magenschleimhaut verglichen werden. Mittels Ultraschall wurde bei 7 Probanden untersucht, ob gekuhlter Orangensaft als Testmahlzeit geeignet ist. Ergebnisse: Gegenuber dem serologischen bzw. histologischen Untersuchungsergebnis als Referenzmethode wies der fur Kinder ermittelte Grenzwert ( δ -Wert = 5 ‰) eine Sensitivitat bzw. Spezifitat von 70 bzw. 95 % und 100 bzw. 100 % auf. Kalter Orangensaft war in der Lage, die Magenentleerung signifikant fur die Dauer des Atemtests zu hemmen und erfullt damit die Kriterien einer Testmahlzeit. 30 min nach 13C-Harnstoff-Einnahme war der optimale Zeitpunkt fur den 2. Probesammelzeitpunkt. Schlusfolgerung: Auch in seiner kindgerechten Modifikation ist der 13C-Harnstoff-Atemtest zur Diagnose einer Infektion mit Helicobacter pylori geeignet.
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- 1997
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10. Simultane Bestimmung anorganischer Anionen in Körperflüssigkeiten
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F. Reineke, I. Böhn, K. H. Niessen, and M. Teufel
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Saliva ,Chromatography ,Mineralogy ,Bromoderma ,Urine ,medicine.disease ,Chloride ,chemistry.chemical_compound ,chemistry ,Nitrate ,Bromide ,Pediatrics, Perinatology and Child Health ,medicine ,Nitrite ,Sulfate ,medicine.drug - Abstract
The anions analysis was a methodical problem up to now. This was the reason for low interest. Biological fluids like saliva and urine which could easily receive without any stress for the children, are little investigated for its capacity on nitrite, nitrate, bromide and sulfate. In this performance there will presented an ion-chromatographic method to determine inorganic anions in the following body-fluids: serum saliva, liquor and urine. The anions chloride, nitrite, bromide, nitrate, phosphate and sulfate was determined quantitatively. The method was proved in a pilot-study on children's body-fluids serum, liquor and saliva. The objects was to get a landmark in expectation from anion concentrations. Bromide was detected as a constant part in all body fluids. The origin and importance is not clear till now. Also was found nitrate in all investigated body fluids. There seems to be a connection between diarrhea and an increase in serum levels from nitrate. We found considerable amounts of nitrate in saliva by babies and infants. The method is distinguished by little fluctuation in measurement and high specificity. Short time in analysis and simple handling will do the method for a qualified one in pediatrics.
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- 1994
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11. Learning-in-(Inter)Action: A Dialogical Turn to Evaluation and Learning
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Theo J. H. Niessen, Tineke A. Abma, Guy A. M. Widdershoven, and Cees P. M. van der Vleuten
- Published
- 2009
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12. Precision electroweak measurements on the Z resonance
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Schael, S Barate, R Bruneliere, R Buskulic, D De Bonis, I Decamp, D Ghez, P Goy, C Jezequel, S Lees, JP and Lucotte, A Martin, F Merle, E Minard, MN Nief, JY and Odier, P Pietrzyk, B Trocme, B Bravo, S Casado, MP and Chmeissani, M Comas, P Crespo, JM Fernandez, E and Fernandez-Bosman, M Garrido, L Grauges, E Juste, A and Martinez, M Merino, G Miquel, R Mir, LM Orteu, S and Pacheco, A Park, IC Perlas, J Riu, I Ruiz, H and Sanchez, F Colaleo, A Creanza, D De Filippis, N de Palma, M Iaselli, G Maggi, G Maggi, M Nuzzo, S and Ranieri, A Raso, G Ruggieri, F Selvaggi, G Silvestris, L and Tempesta, P Tricomi, A Zito, G Huang, X Lin, J and Ouyang, Q Wang, T Xie, Y Xu, R Xue, S Zhang, J and Zhang, L Zhao, W Abbaneo, D Bazarko, A Becker, U and Boix, G Bird, F Blucher, E Bonvicini, B Bright-Thomas, P and Barklow, T Buchmuller, O Cattaneo, M Cerutti, F and Ciulli, V Clerbaux, B Drevermann, H Forty, RW Frank, M and Greening, TC Hagelberg, R Halley, AW Gianotti, F and Girone, M Hansen, JB Harvey, J Jacobsen, R Hutchcroft, DE Janot, R Jost, B Knobloch, J Kado, M Lehraus, I and Lazeyras, P Maley, R Mato, P May, J Moutussi, A and Pepe-Altarelli, M Ranjard, F Rolandi, L Schlatter, D and Schmitt, B Schneider, O Tejessy, W Teubert, F Tomalin, IR Tournefier, E Veenhof, R Valassi, A Wiedenmann, W and Wright, AE Ajaltouni, Z Badaud, F Chazelle, G Deschamps, O Dessagne, S Falvard, A Ferdi, C Fayolle, D Gay, P and Guicheney, C Henrard, P Jousset, J Michel, B and Monteil, S Montret, JC Pallin, D Pascolo, JM Perret, P and Podlyski, F Bertelsen, H Fernley, T Hansen, JD and Hansen, JR Hansen, PH Kraan, AC Lindahl, A Mollerud, R and Nilsson, BS Rensch, B Waananen, A Daskalakis, G and Kyriakis, A Markou, C Simopoulou, E Siotis, I Vayaki, A and Zachariadou, K Blondel, A Bonneaud, G Brient, JC and Machefert, E Rouge, A Rumpf, M Swynghedauw, M Tanaka, R and Verderi, M Videau, H Ciulli, V Focardi, E Parrini, G and Zachariadou, K Corden, M Georgiopoulos, C Antonelli, A and Antonelli, M Bencivenni, G Bologna, G Bossi, F and Campana, P Capon, G Cerutti, F Chiarella, V Felici, G and Laurelli, P Mannocchi, G Murtas, GP Passalacqua, L and Picchi, P Colrain, P Ten Have, I Hughes, IS Kennedy, J and Knowles, IG Lynch, JG Morton, WT Negus, P O'Shea, V and Raine, C Reeves, P Scarr, JM Smith, K Thompson, AS and Turnbull, RM Wasserbaech, S Buchmuller, O Cavanaugh, R and Dhamotharan, S Geweniger, C Hanke, P Hansper, G and Hepp, V Kluge, EE Putzer, A Sommer, J Stenzel, H and Tittel, K Werner, W Wunsch, M Beuselinck, R Binnie, DM and Cameron, W Davies, G Dornan, PJ Goodsir, S and Marinelli, N Martin, EB Nash, J Nowell, J Rutherford, SA and Sedgbeer, JK Thompson, JC White, R Williams, MD and Ghete, VM Girtler, P Kneringer, E Kuhn, D Rudolph, G and Bouhova-Thacker, E Bowdery, CK Buck, PG Clarke, DP and Ellis, G Finch, AJ Foster, F Hughes, G Jones, RWL and Keemer, NR Pearson, MR Robertson, NA Sloan, T Smizanska, M Snow, SW Williams, MI van der Aa, O Delaere, C and Leibenguth, G Lemaitre, V Bauerdick, LAT Blumenschein, U and van Gemmeren, P Giehl, I Holldorfer, F Jakobs, K and Kasemann, M Kayser, F Kleinknecht, K Muller, AS Quast, G and Renk, B Rohne, E Sander, HG Schmeling, S Wachsmuth, H Wanke, R Zeitnitz, C Ziegler, T Aubert, JJ and Benchouk, C Bonissent, A Carr, J Coyle, P Curtil, C and Ealet, A Etienne, F Fouchez, D Motsch, F Payre, P and Rousseau, D Tilquin, A Talby, M Thulasides, M Aleppo, M and Antonelli, M Ragusa, F Buscher, V David, A Dietl, H and Ganis, G Huttmann, K Lutjens, G Mannert, C Manner, W and Moser, HG Settles, R Seywerd, H Stenzel, H Villegas, M Wiedenmann, W Wolf, G Azzurri, P Boucrot, J and Callot, O Chen, S Cordier, A Davier, M Duflot, L and Grivaz, JF Heusse, P Jacholkowska, A Le Diberder, F and Lefrancois, J Mutz, AM Schune, MH Serin, L Veillet, JJ and Videau, I Zerwas, D Azzurri, P Bagliesi, G and Bettarini, S Boccali, T Bozzi, C Calderini, G Dell'Orso, R Fantechi, R Ferrante, I Fidecaro, F Foa, L and Giammanco, A Giassi, A Gregorio, A Ligabue, F Lusiani, A and Marrocchesi, PS Messineo, A Palla, F Rizzo, G and Sanguinetti, G Sciaba, A Sguazzoni, G Spagnolo, P and Steinberger, J Tenchini, R Venturi, A Vannini, C and Venturi, A Verdini, PG Awunor, O Blair, GA Cowan, G and Garcia-Bellido, A Green, MG Medcalf, T Misiejuk, A and Strong, JA Teixeira-Dias, P Botterill, DR Clifft, RW and Edgecock, TR Edwards, M Haywood, SJ Norton, PR Tomalin, IR Ward, JJ Bloch-Devaux, B Boumediene, D Colas, P and Emery, S Fabbro, B Kozanecki, W Lancon, E Lemaire, MC and Locci, E Perez, P Rander, J Renardy, JF Roussarie, A and Schuller, JP Schwindling, J Tuchming, B Vallage, B and Black, SN Dann, JH Kim, HY Konstantinidis, N Litke, AM and McNeil, MA Taylor, G Booth, CN Cartwright, S and Combley, F Hodgson, PN Lehto, M Thompson, LF and Affholderbach, K Barberio, E Bohrer, A Brandt, S and Burkhardt, H Feigl, E Grupen, C Hess, J Lutters, G and Meinhard, H Minguet-Rodriguez, J Mirabito, L Misiejuk, A and Neugebauer, E Ngac, A Prange, G Rivera, F Saraiva, P and Schafer, U Sieler, U Smolik, L Stephan, F Trier, H and Apollonio, M Borean, C Bosisio, L Della Marina, R and Giannini, G Gobbo, B Musolino, G Pitis, L He, H Kim, H Putz, J Rothberg, J Armstrong, SR Bellantoni, L and Berkelman, K Cinabro, D Conway, JS Cranmer, K Elmer, P and Feng, Z Ferguson, DPS Gao, Y Gonzalez, S Grahl, J and Harton, JL Hayes, OJ Hu, H Jin, S Johnson, RP and Kile, J McNamara, PA Nielsen, J Orejudos, W Pan, Y and Saadi, Y Scott, IJ Sharma, V Walsh, AM Walsh, J and Wear, J von Wimmersperg-Toeller, JH Wiedenmann, W Wu, J and Wu, SL Wu, X Yamartino, JM Zobernig, G Dissertori, G and Abdallah, J Abreu, P Adam, W Adye, T Adzic, P and Ajinenko, I Albrecht, T Alderweireld, T Alekseev, GD and Alemany-Fernandez, R Allmendinger, T Allport, PP Almehed, S and Amaldi, U Amapane, N Amato, S Anashkin, E and Anassontzis, EG Andersson, P Andreazza, A Andringa, S and Anjos, N Antilous, P Apel, WD Arnoud, Y Ask, S and Asman, B Augustin, JE Augustinus, A Baillon, P and Ballestrero, A Bambade, P Barao, F Barbiellini, G and Barbier, R Bardin, D Barker, G Baroncelli, A Battaglia, M Baubillier, M Becks, KH Begalli, M Behrmann, A and Beilliere, P Belokopytov, Y Belous, K Ben-Haim, E and Benekos, N Benvenuti, A Berat, C Berggren, M Berntzon, L and Bertini, D Bertrand, D Besancon, M Besson, N and Bianchi, F Bigi, M Bilenky, MS Bizouard, MA Bloch, D and Blom, M Bluj, M Bonesini, M Bonivento, W Boonekamp, M and Booth, PSL Borgland, AW Borisov, G Bosio, C Botner, O Boudinov, E Bouquet, B Bourdarios, C Bowcock, TJV and Boyko, I Bozovic, I Bozzo, M Bracko, M Branchini, P and Brenke, T Brenner, R Brodet, E Bruckman, P Brunet, JM and Bugge, L Buran, T Burgsmueller, T Buschbeck, B and Buschmann, P Cabrera, S Caccia, M Calvi, M Rozas, AJC and Camporesi, T Canale, V Canepa, M Carena, F Carroll, L Caso, C Gimenez, MVC Castro, N Cattai, A Cavallo, F Cerruti, C Chabaud, V Chapkin, M Charpentier, P and Chaussard, L Checchia, P Chelkov, GA Chen, M Chierici, R and Chliapnikov, R 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Duda, M Duinker, P Duran, I Dutta, S Echenard, B and Eline, A El Hage, A El Mamouni, H Engler, A Eppling, FJ Erne, FC Extermann, P Fabre, M Faccini, R and Falagan, MA Falciano, S Favara, A Fay, J Fedin, O and Felcini, M Ferguson, T Ferroni, F Fesefeldt, H and Fiandrini, E Field, JH Filthaut, F Fisher, PH Fisher, W and Fisk, I Forconi, G Fredj, L Freudenreich, K Furetta, C Galaktionov, Y Ganguli, SN Garcia-Abia, P Gataullin, M and Gau, SS Gentile, S Gheordanescu, N Giagu, S Gong, ZF and Grenier, G Grimm, O Gruenewald, MW Guida, M van Gulik, R van Gupta, VK Gurtu, A Gutay, LJ Haas, D and Hasan, A Hatzifotiadou, D Hebbeker, T Herve, A Hidas, P and Hirschfelder, J Hofer, H Hohlmann, M Holzner, G and Hoorani, H Hou, SR Lashvili, I Innocente, V Jin, BN and Jindal, P Jones, LW deJong, P Josa-Mutuberria, I Khan, RA Kaur, M Kienzle-Focacci, MN Kim, D Kim, JK and Kirkby, J Kiss, D Kittel, W Klimentov, A Konig, AC and Koffeman, E Kopal, M Kopp, A Koutsenko, V Kraber, M and Kraemer, RW Krenz, W Kruger, A Kuijten, H Kunin, A and de Guevara, PL Laktineh, I Landi, G Lassila-Perini, K and Lebeau, M Lebedev, A Lebrun, P Lecomte, P Lecoq, P and Le Coultre, P Lee, HJ Le Goff, JM Leiste, R Leonardi, E and Levtchenko, M Levtchenko, P Li, C Likhoded, S Lin, CH Lin, WT Linde, FL Lista, L Liu, ZA Lohmann, W and Longo, E Lu, YS Lu, W Lubelsmeyer, K Luci, C Luckey, D Luminari, L Lugnier, L Lustermann, W Ma, WG Maity, M Malgeri, L Malinin, A Mana, C Mangeol, D Mans, J and Marchesini, P Marian, G Martin, JP Marzano, F and Massaro, GGG Mazumdar, K McNeil, RR Mele, S Merola, L and Merk, M Meschini, M Metzger, WJ von der Mey, M and Mihul, A Milcent, H Mirabelli, G Mnich, J Mohanty, GB and Molnar, P Monteleoni, B Moulik, T Muanza, GS Muheim, F Muijs, AJM Musicar, B Musy, M Nagy, S Natale, S and Napolitano, M Nessi-Tedaldi, F Newman, H Niessen, T and Nisati, A Novak, I Nowak, H Ofierzynski, R Organtini, G and Oulianov, A Pal, I Palomares, C Pandoulas, D and Paoletti, S Paoloni, A Paolucci, P Paramatti, R Park, HK and Park, IH Pascale, G Passaleva, G Patricelli, S Paul, T Pauluzzi, M Paus, C Pauss, F Peach, D Pedace, M and Pensotti, S Perret-Gallix, D Petersen, B Piccolo, D and Pierella, F Pieri, M Pioppi, M Piroue, PA Pistolesi, E and Plyaskin, V Pohl, M Pojidaev, V Postema, H Pothier, J Produit, N Prokofiev, DO Prokofiev, D Quartieri, J and Rahal-Callot, G Rahaman, MA Raics, P Raja, N Ramelli, R and Rancoita, PG Ranieri, R Raspereza, A Razis, P Ren, D and Rescigno, M Reucroft, S van Rhee, T Riemann, S and Riles, K Robohm, A Rodin, J Roe, BP Romero, L Rosca, A Rosemann, C Rosenbleck, C Rosier-Lees, S Roth, S and Rubio, JA Ruggiero, G Ruschmeier, D Rykaczewski, H and Sakharov, A Saremi, S Sarkar, S Salicio, J Sanchez, E and Sanders, MP Sarakinos, ME Schafer, C Schegelsky, V and Schmidt-Kaerst, S Schmitz, D Schopper, H Schotanus, DJ and Schwering, G Sciacca, C Sciarrino, D Seganti, A Servoli, L Shevchenko, S Shivarov, N Shoutko, V Shumilov, E and Shvorob, A Siedenburg, T Son, D Smith, B Souga, C and Spillantini, P Steuer, M Stickland, DP Stone, A Stone, H and Stoyanov, B Straessner, A Sudhakar, K Sultanov, G and Sun, LZ Sushkov, S Suter, H Swain, JD Szillasi, Z and Sztaricskai, T Tang, XW Tarjan, P Tauscher, L Taylor, L and Tellili, B Teyssier, D Timmermans, C Ting, SCC Ting, SM Tonwar, SC Toth, J Tully, C Tung, KL Uchida, Y and Ulbricht, J Uwer, U Valente, E Van de Walle, RT and Vasquez, R Veszpremi, V Vesztergombi, G Vetlitsky, I and Vicinanza, D Viertel, G Villa, S Vivargent, M Vlachos, S and Vodopianov, I Vogel, H Vogt, H Vorobiev, I Vorobyov, AA Vorvolakos, A Wadhwa, M Wallraff, W Wang, Q Wang, XL Wang, ZM Weber, A Weber, M Wienemann, P Wilkens, H Wu, SX Wynhoff, S Xia, L Xu, ZZ Yamamoto, J and Yang, BZ Yang, CG Yang, HJ Yang, M Ye, JB Yeh, SC and You, JM Zalite, A Zalite, Y Zhang, ZP Zhao, J and Zhu, GY Zhu, RY Zhuang, HL Zichichi, A Zilizi, G and Zimmermann, B Zoller, M Abbiendi, G Acton, PD Ainsley, C and Akesson, PF Alexander, G Allison, J Allport, PP and Altekamp, N Amaral, P Ametewee, K Anagnostou, G and Anderson, KJ Anderson, S Arcelli, S Armitage, JC Asai, S and Ashby, SF Ashton, P Astbury, A Axen, D Azuelos, G and Bahan, GA Bailey, I Baines, JTM Ball, AH Banks, J and Barberio, E Barillari, T Barker, GJ Barlow, RJ and Barnett, S Bartoldus, R Batley, RJ Beaudoin, G Bechtle, P Bechtluft, J Beck, A Becker, J Beeston, C Behnke, T Bell, AN Bell, KW Bell, PJ Bella, G Bellerive, A and Benelli, G Bentvelsen, S Berlich, P Bethke, S and Biebel, O Binder, U Blobel, V Bloodworth, IJ Bloomer, JE and Bock, P Boden, B Bohme, J Boeriu, O Bonacorsi, D and Bosch, HM Bougerolle, S Bouterneur, M Bouwens, BT and Brabson, BB Braibant, S Breuker, H Bright-Thomas, P and Brigliadori, L Brown, RM Brun, R Burgin, R Buesser, K and Buijs, A Burckhart, HJ Burgard, C Cammin, J Campana, S Capiluppi, P Carnegie, RK Caron, B Carter, AA and Carter, JR Chang, CY Charlesworth, C Charlton, DG Chrin, JTM Chrisman, D Chu, SL Ciocca, C Clarke, PEL Clay, E Clayton, JC Cohen, I Collins, WJ Conboy, JE Cooke, OC Cooper, M Couch, M Couchman, J Coupland, M Silva, ED Coxe, RL Csilling, A Cuffiani, M Dado, S and Dallapiccola, C Dallavalle, GM Dallison, S Darling, C De Jong, S De Roeck, A De Wolf, EA Debu, P Deng, H and Deninno, MM Dervan, P Desch, K Dieckmann, A Dienes, B and Dittmar, M Dixit, MS Donkers, M Doucet, M Dubbert, J and Duboscq, JE Duchovni, E Duckeck, G Duerdoth, IP and Dumas, DJP Eckerlin, G Edwards, JEG Elcombe, PA and Estabrooks, PG Etzion, E Evans, HG Evans, M Fabbri, F and Fanti, M Fath, P Feld, L Ferrari, P Fiedler, F and Fierro, M Fincke-Keeler, M Fischer, HM Fleck, I Folman, R Fong, DG Ford, M Foucher, M Frey, A Furtjes, A and Fukui, H Fukunaga, C Futyan, DI Gagnon, P Gaidot, A and Ganel, O Gary, JW Gascon, J Gascon-Shotkin, SM Gaycken, G Geddes, NI Geich-Gimbel, C Gensler, SW Gentit, FX and Geralis, T Giacomelli, G Giacomelli, P Giacomelli, R and Gibson, V Gibson, WR Gillies, JD Gingrich, DM Giunta, M and Glenzinski, D Goldberg, J Goodrick, MJ Gorn, W and Graham, K Grandi, C Grant, FC Gross, E Grunhaus, J and Gruwe, M Gunther, PO Gupta, A Hagemann, J Hajdu, C and Hamann, M Hanson, GG Hansroul, M Hapke, M Harder, K and Harel, A Hargrovet, CK Harin-Dirac, M Harrison, PF Hart, PA Hartmann, C Hattersley, PM Hauschild, M Hawkes, CM and Hawkings, R Heflin, E Hemingway, RJ Hensel, C and Herten, G Heuer, RD Hildreth, MD Hill, JC Hillier, SJ and Hilse, T Hinshaw, DA Ho, C Hoare, J Hobbs, JD and Hobson, PR Hochman, D Hocker, A Hoffman, K Holl, B and Homer, RJ Honma, AK Horvath, D Hossain, KR Hou, SR and Howard, R Howarth, CP Huntemeyer, P Hughes-Jones, RE and Humbert, R Hutchcroft, DE Igo-Kemenes, P Ihssen, H and Imrie, DC Ingram, M Ishii, K Jacob, FR Janissen, AC and Jawahery, A Jeffreys, PW Jeremie, H Jimack, M Jobes, M and Joly, T Jones, CR Jones, G Jones, M Jones, RWL and Jost, U Jovanovic, P Jui, C Jobes, M Joly, A Jones, CR Jones, G Jones, M Jones, RWL Jost, U Jovanovic, P and Jui, C Junk, TR Kanaya, N Kanzaki, J Karapetian, G and Karlen, D Kartvelishvili, V Kawagoe, K Kawamoto, T and Keeler, RK Kellogg, RG Kennedy, BW Kim, DH King, BJ and Kirk, J Klein, K Kleinwort, C Klem, DE Klier, A and Kluth, S Kobayashi, T Kobel, M Kopke, L Koetke, DS and Kokott, TP Komamiya, S Kormos, L Kowalewski, R Kramer, T and Kral, JF Kress, T Kreutzmann, H Krieger, P von Krogh, J Kroll, J Krop, D Kruger, K Kuhl, T Kupper, M Kuwano, M Kyberd, P Lafferty, GD Lafoux, H and Lahmann, R Lai, WP Lamarche, F Landsman, H Lanske, D and Larson, WJ Lauber, J Lautenschlager, SR Lawson, I and Layter, JG Lazic, D Le Du, P Leblanc, P Lee, AM and Lefebvre, E Lehto, MH Leins, A Lellouch, D Lennert, P and Leroy, C Lessard, L Letts, J Levegrun, S Levinson, L and Lewis, C Liebisch, R Lillich, J Littlewood, C Lloyd, AW Lloyd, SL Loebinger, FK Long, GD Lorah, JM and Lorazo, B Losty, MJ Lou, XC Lu, J Ludwig, A Ludwig, J Luig, A Macchiolo, A Macpherson, A Mader, W and Mattig, P Malik, A Mannelli, M Marcellini, S Marchant, TE Maringer, G Markus, C Martin, A Martin, JP and Martinez, G Masetti, G Mashimo, T Matthews, W Maur, U and McDonald, WJ McGowan, RF McKenna, J Mckigney, EA and McMahon, TJ McNab, AI McNutt, J McPherson, AC McPherson, RA Meijers, F Mendez-Lorenzo, P Menges, W Menke, S and Menszner, D Merritt, FS Mes, H Meyer, J Meyer, N and Michelini, A Middleton, RP Mihara, S Mikenberg, G and Mildenberger, J Miller, DJ Milstene, C Mir, R Moed, S and Mohr, W Moisan, C Montanari, A Mori, T Morii, M and Moss, MW Mouthuy, T Muller, U Murphy, PG Mutter, A and Nagai, K Nakamura, I Nanjo, H Neal, HA Nellen, B and Nguyen, HH Nijjhar, B Nisius, R Nozaki, M Oakham, FG and Odorici, F Ogg, M Ogren, HO Oh, A Oh, H Okpara, A and Oldershaw, NJ Omori, T O'Neale, SW O'Neill, BP Oram, CJ Oreglia, MJ Orito, S Pahl, C Palinkas, J and Palmonari, F Pansart, JP Panzer-Steindel, B Paschievici, P and Pasztor, G Pater, JR Patrick, GN Pawley, SJ and Paz-Jaoshvili, N Pearce, MJ Petzold, S Pfeifenschneider, P and Pfister, P Pilcher, JE Pinfold, J Pitman, D Plane, DE Poffenberger, P Poli, B Polok, J Pooth, O and Posthaus, A Pouladdej, A del Poz, LA Prebys, E and Pritchard, TW Przybycien, M Przysiezniak, H Quadt, A and Quast, G Rabbertz, K Raith, B Redmond, MW Rees, DL and Rembser, C Renkel, P Richards, GE Rick, H Rigby, D and Riles, K Robins, SA Robinson, D Rodning, N Rollnik, A and Roney, JM Rooke, A Ros, E Rosati, S Roscoe, K and Rossberg, S Rossi, AM Rosvick, M Routenburg, P Rozen, Y and Runge, K Runolfsson, O Ruppel, U Rust, DR Rylko, R and Sachs, K Saeki, T Sahr, O Sanghera, S Sarkisyan, EKG and Sasaki, M Sbarra, C Schaile, AD Schaile, O and Schappert, W Scharf, F Scharff-Hansen, P Schenk, P and Schieck, J Schmitt, B von der Schmitt, H Schmitt, S and Schorner-Sadenius, T Schreiber, S Schroder, M Schutz, P and Schultz-Coulon, HC Schulz, M Schumacher, M Schwarz, J and Schwick, C Schwiening, J Scott, WG Settles, M Seuster, R and Shears, TG Shen, BC Shepherd-Themistocleous, CH and Sherwood, P Shypit, R Simon, A Singh, P Siroli, GP and Sittler, A Skillman, A Skuja, A Smith, AM Smith, TJ and Snow, GA Sobie, R Soldner-Rembold, S Spagnolo, S Spano, F Springer, RW Sproston, M Stahl, A Starks, M and Steiert, M Stephens, K Steuerer, J Stier, HE and Stockhausen, B Stoll, K Strohmer, R Strom, D Strumia, F and Stumpf, L Surrow, B Szymanski, P Tafirout, R Takeda, H Takeshita, T Talbot, SD Tanaka, S Taras, P Tarem, S Tasevsky, M Taylor, RJ Tecchio, M Teixeira-Dias, P and Tesch, N Teuscher, R Thackray, NJ Thiergen, M Thomas, J and Thomson, MA von Torne, E Torrence, E Towers, S Toya, D Trocsanyi, Z Tran, P Transtromer, G Trefzger, T and Tresilian, NJ Trigger, I Tscheulin, M Tsukamoto, T Tsur, E Turcot, AS Tumer-Watson, MF Tysarczyk-Niemeyer, G and Ueda, I Ujvari, B Utzat, P Vachon, B Van den Plas, D and Van Kooten, R VanDalen, GJ Vannerem, P Vasseur, G and Vertesi, R Verzocchi, M Vikas, P Vincter, M Virtue, CJ and Vokurka, EH Vollmer, CF Voss, H Vossebeld, J and Wackerle, F Wagner, A Wagner, DL Wahl, C Walker, JP and Waller, D Ward, CP Ward, DR Ward, JJ Watkins, PM and Watson, AT Watson, NK Weber, M Weber, P Weisz, S and Wels, PS Wengler, T Wermes, N Wetterling, D Weymann, M and Whalley, MA White, JS Wilkens, B Wilson, JA Wilson, GW Wingerter, I Winterer, VH Wlodek, T Wolf, G Wood, NC Wotton, S Wyatt, TR Yaari, R Yamashita, S Yang, Y and Yeaman, A Yekutieli, G Yurko, M Zacek, V Zacharov, I and Zer-Zion, D Zeuner, W Zivkovic, L Zorn, GT Abe, K and Abe, K Abe, T Abt, I Acton, PD Adam, I Agnew, G and Akagi, T Akimoto, H Allen, NJ Ash, WW Aston, D and Bacchetta, N Baird, KG Baltay, C Band, HR Barakat, MB and Baranko, GJ Bardon, O Barklow, TL Bashindzhagian, GL and Battiston, R Bauer, JM Bazarko, AO Bean, A Bellodi, G and Ben-David, R Benvenuti, AC Berger, R Biasini, M and Bienz, T Bilei, GM Bisello, D Blaylock, G Bogart, J and Bolen, B Bolton, T Bower, GR Brau, JE Breidenbach, M and Bugg, WM Burke, D Burnett, TH Burrows, PN Busza, W and Calcaterra, A Caldwell, DO Camanzi, B Carpinelli, M and Carr, J Cassell, R Castaldi, R Castro, A Cavalli-Sforza, M Chadwick, GB Chou, A Church, E Claus, R Cohn, HO and Coller, JA Convery, MR Cook, V Cotton, R Cowan, RF and Coyle, PA Coyne, DG Crawford, G D'Oliveira, A and Damerell, CJS Daoudi, M Dasu, S de Groot, N de Sangro, R and De Simone, P De Simone, S Dell'Orso, R Dervan, PJ and Dima, M Dong, DN Doser, M Du, PYC Dubois, R Duboscq, JE Eigen, G Eisenstein, BI Elia, R Erdos, E and Erofeeva, I Eschenburg, V Etzion, E Fahey, S Falciai, D and Fan, C Fernandez, JP Fero, MJ Flood, K Frey, R and Friedman, JI Furuno, K Garwin, EL Gillman, T Gladding, G and Gonzalez, S Hallewell, GD Hart, EL Harton, JL Hasan, A Hasegawa, Y Hasuko, K Hedges, S Hertzbach, SS and Hildreth, MD Hitlin, DG Honma, A Huber, JS Huffer, ME and Hughes, EW Huynh, X Hwang, H Iwasaki, M Iwasaki, Y and Izen, JM Jackson, DJ Jacques, P Jaros, JA Jiang, ZY and Johnson, AS Johnson, JR Johnson, RA Junk, T and Kajikawa, R Kalelkar, M Kamyshkov, YA Kang, HJ Karliner, I Kawahara, H Kelsey, MH Kendall, HW Kim, YD King, M and King, R Kofler, R Krishna, NM Kwon, Y Labs, JF and Kroeger, RS Langston, M Lath, A Lauber, JA Leith, DWG and Lia, V Lin, C Liu, MX Loreti, M Lu, A Lynch, HL and Ma, J Mancinelli, G Manly, S Mantovani, G and Markiewicz, TW Maruyama, T Masuda, H Mazzucato, H and McGowan, JF McKemey, AK Meadows, BT Messner, R Mockett, PM Moffeit, KC Moore, TB Morii, M Mours, B Muller, D and Mueller, G Murzin, V Nagamine, T Narita, S and Nauenberg, U Neal, H Nesom, G Nussbaum, M Ohnishi, Y and Oishi, N Onoprienko, D Osborne, LS Panvini, RS Park, CH and Park, H Pavel, TJ Peruzzi, I Pescara, L Piccolo, M and Piemontese, L Pieroni, E Pitts, KT Plano, RJ and Prepost, R Prescott, CY Punkar, G Quigley, J Ratcliff, BN Reeves, K Reeves, TW Reidy, J Reinertsen, PL and Rensing, PE Rochester, LS Rothberg, JE Rowson, PC and Russell, JJ Saxton, OH Schalk, T Schindler, RH and Schneekloth, U Schumm, BA Schwiening, J Seiden, A Sen, S and Serbo, VV Servoli, L Shaevitz, MH Shank, JT Shapiro, G Sherden, DJ Shmakov, KD Simopoulos, C Sinev, NB and Smith, SR Smy, MB Snyder, JA Sokoloff, MD Staengle, H and Stahl, A Starner, P Steiner, H Steiner, R Strauss, MG Su, D Suekane, F Sugiyama, A Suzuki, A Suzuki, S and Swartz, M Szumilo, A Takahashi, T Taylor, FE Thaler, JJ Thom, J Torrence, E Trandafir, AI Turk, JD Usher, T Va'vra, J Vannini, C Vella, E Venuti, JP Verdier, R Verdini, PG Wagner, DL Wagner, SR Waite, AP and Walston, S Wang, J Watts, SJ Weidemann, AW Weiss, ER and Whitaker, JS White, SL Wickens, FJ Williams, DA and Williams, DC Williams, SH Willocq, S Wilson, RJ and Wisniewski, WJ Wittlin, JL Woods, M Word, GB Wright, TR and Wyss, J Yamamoto, RK Yamartino, JM Yang, XQ Yashima, J Yellin, SJ Young, CC Yuta, H Zapalac, G Zdarko, RW and Zeitlin, C Zhou, J ALEPH Collaborat DELPHI Collaborat and L3 Collaborat OPAL Collaborat SLD Collaborat
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High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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- 2006
13. Case 2. Intracardiac metastasis from a Merkel cell carcinoma
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M R M, Jongbloed, B L J, Kanen, M, Visser, H, Niessen, M J, Flens, and R J L F, Loffeld
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Carcinoma, Merkel Cell ,Heart Neoplasms ,Fatal Outcome ,Skin Neoplasms ,Humans ,Female ,Heart Atria ,Middle Aged - Published
- 2004
14. [Congenital pulmonary fibrosarcoma. Differential diagnosis of infantile pulmonary spindle cell tumors]
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C, Kuhnen, D, Harms, K H, Niessen, T, Diehm, and K M, Müller
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Diagnosis, Differential ,Lung Neoplasms ,Fibrosarcoma ,Infant, Newborn ,Humans ,Sarcoma ,Tomography, X-Ray Computed - Abstract
Primary pulmonary mesenchymal tumors are rare causes of intrathoracic lesions in newborns. We describe a case of pulmonary spindle-cell tumor with features of infantile fibrosarcoma and discuss the differential diagnosis of spindle-cell lesions in this location. In view of further case reports of the literature, this neoplasia can best be categorized in a spectrum of fibroblastic/myofibroblastic differentiated spindle-cell tumors, with excellent prognosis. Especially in congenital lesions a favorable clinical course is to be expected after complete surgical resection. Additional radio- and/or chemotherapy is not recommended.
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- 2001
15. Amadori albumin and advanced glycation end-product formation in peritoneal dialysis using icodextrin
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N, Posthuma, P M, ter Wee, H, Niessen, A J, Donker, H A, Verbrugh, and C G, Schalkwijk
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Adult ,Glycation End Products, Advanced ,Male ,Enzyme-Linked Immunosorbent Assay ,In Vitro Techniques ,Middle Aged ,Icodextrin ,Glucose ,Albumins ,Dialysis Solutions ,Humans ,Kidney Failure, Chronic ,Female ,Glucans ,Peritoneal Dialysis ,Aged - Abstract
To study the influence of peritoneal dialysis (PD) solutions on the formation of early glycated products and advanced glycation end-products (AGEs).The formation of both Amadori albumin and AGEs in glucose- and icodextrin-based PD fluids was analyzed in vitro and in peritoneal effluents of continuous cyclic peritoneal dialysis (CCPD) patients.Albumin incubated with glucose-based PD fluids showed a time- and glucose concentration-dependent formation of Amadori albumin and AGEs. Aminoguanidine completely inhibited AGE but not Amadori albumin formation. Albumin incubated in icodextrin resulted in the lowest levels of Amadori albumin and AGE. Amadori albumin levels in effluents of 24 CCPD patients (12 glucose and 12 icodextrin for their daytime dwells) were similar. Dialysate samples collected during a mass transfer area coefficient test in 16 CCPD patients (8 glucose, 8 icodextrin) showed an increase in Amadori albumin formation from baseline (p0.0001), without a difference between the groups. In the total group, there was a positive relationship between duration on PD and dialysate Amadori albumin concentration at 240 minutes (p = 0.03). The Amadori albumin dialysate-to-plasma (D/P) ratio at 240 minutes was 0.82+/-0.11, and its clearance amounted to 7.71+/-1.14 mL/min, while the albumin D/P ratio was 0.010+/-0.003 and its clearance was 0.089+/-0.017 mL/min. In a peritoneal biopsy of a CCPD patient, Amadori albumin was observed in the mesothelial layer and the endothelium of the peritoneum.Using icodextrin-based instead of glucose-based PD fluids can largely reduce the formation of Amadori albumin and AGEs. However, CCPD patients using icodextrin during daytime dwells do not have lower effluent levels of Amadori albumin and AGEs, probably due to the exposure to glucose during their nighttime exchanges. Kinetic studies suggest washout of locally produced Amadori albumin.
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- 2001
16. Toxaphenes and chlorinated naphthalenes in adipose tissue of children
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K Witt and K H Niessen
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Insecticides ,Camphechlor ,Urban Population ,Adipose tissue ,Naphthalenes ,West germany ,Toxaphene ,chemistry.chemical_compound ,Germany ,Medicine ,Humans ,Child ,Bicyclic Monoterpenes ,Camphanes ,business.industry ,Terpenes ,Gastroenterology ,Pesticide ,Multicenter study ,chemistry ,Adipose Tissue ,Environmental chemistry ,Pediatrics, Perinatology and Child Health ,business ,Chlorine Compounds - Abstract
Background Chlorinated hydrocarbons are ingested by humans in food and accumulate in adipose tissue. At the University Kinderklinik, Mannheim, previously unknown substances have been found in children (e.g., the pesticide toxaphene and chlorinated naphthalenes). These substances have been widely used for industrial purposes in the past. Samples from West and East Germany; Saratov, Russia; and Almaty, Kazakhstan were examined to determine whether these substances are ubiquitous. Methods After Soxhlet extraction, the extracts were cleaned up using a liquid chromatographic technique. Measurement was performed by gas chromatography-mass spectrometry using negative chemical ionization in the single-ion-monitoring mode. Result In specimens from all cities, toxaphene congeners Parlar 26 and Parlar 50 and six chlorinated naphthalenes were traced. Highest median load of toxaphene was 1.97 microg/kg for Parlar 26 and 2.36 microg/kg for Parlar 50 in Stralsund, East Germany. For chlorinated naphthalenes, the median was highest in Mannheim, West Germany, with 12.0 microg/kg. Conclusion These findings show that monitoring these toxic substances remains necessary. Even though the use and as a consequence the amount of chlorinated hydrocarbons were reduced, these substances have by no means disappeared from the environment.
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- 2000
17. Besonderheiten bei der antiretroviralen Therapie eines HIV- positiven Frühgeborenen mit einem Geburtsgewicht von 980 g
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K. Ramasubbu, M. Beichert, B. Buchholz, T. Schaible, K.-H. Niessen, and M. Teich
- Abstract
In der BRD werden seit 1994 zur Verringerung der Rate der vertikalen Transmission die HIV1-positiven Schwangeren und ihre Neugeborenen nach Protokoll ACTG 076 [8] mit Zidovudin/AZT behandelt und die Neugeborenen duch primare Sectio am wehenlosen Uterus entbunden. Mitte 1998 wurde dieses Vorgehen im Rahmen einer Konsensuskonferenz weiter modifiziert, risikoadaptiert und an neueste Erkenntnisse angepast [9]. Seit 1994 betragt in der BRD die Rate der vertikalen HIV1-Infektion nur ca. 2% [2,10]. Unter den wenigen HIV1-infizierten Kindern sind wegen des deutlich erhohten Infektionsrisikos immer haufiger Kinder aus Risikoschwangerschaften mit Komplikationen wie Amnioninfektionssyndrom, vorzeitigem Blasensprung und Fruhgeburtlichkeit. Es gibt mehrere Hinweise darauf, das eine frzeitige antiretrovirale Therapie noch im Suglingsalter den Krankheitsverlauf der HIV1-Infeltion bei diesen Kindern positive beeinflut und die Progression zum Stadium AIDS verzogert. So zeigte eine retrospective Auswertung des Krankheitsverlaufs bei HIV1-positiv Sauglingen bei hohen Viruslasten im ersten Lebensjahr eine deulich schnellere Krankheitsprogredienz mit frherem Erreichen des Stadiums AIDS als bei Suglingen mit niederen Viruslasten [11]. Daher ware eine antiretrovirale Therapie HIV1-infizierter Suglinge mit Senkung der Virulast auch im ersten Lebensjahr wunschenswert. In der BRD ist jedoch eine antiretrovirale Therapie Neugeborener und erst recht Fruhgeborener mangels pharmakokinetischer Daten erst abdem 4. Lebensmonat empfohlen [12] Der folgende Fallreport berichtet uber die Notwendigkeit und Molichkeit einer letzlich erfolgreichen antiretroviralen Dreifachtherapie eines Fruhgeborenen in den ersten drei Lebensmonaten.
- Published
- 2000
- Full Text
- View/download PDF
18. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils
- Author
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H, Niessen, G W, Meisenholder, H L, Li, S L, Gluck, B S, Lee, B, Bowman, R L, Engler, B M, Babior, and R A, Gottlieb
- Subjects
Adult ,Protein Synthesis Inhibitors ,Vacuolar Proton-Translocating ATPases ,Neutrophils ,Hydrogen-Ion Concentration ,Anti-Bacterial Agents ,Up-Regulation ,Proton-Translocating ATPases ,Granulocyte Colony-Stimulating Factor ,Homeostasis ,Humans ,Macrolides ,Cycloheximide ,Enzyme Inhibitors - Abstract
We have previously shown that granulocyte colony-stimulating factor (G-CSF ) delays spontaneous neutrophil apoptosis through activation of the vacuolar proton ATPase (v-ATPase). We have now examined the regulation of the v-ATPase in neutrophils exposed to G-CSF in vitro. When neutrophils were cultivated in the absence of G-CSF, the 57-kD cytosolic B subunit of the v-ATPase disappeared within 1 to 2 hours, its loss preceding the nuclear changes of apoptosis and coinciding with the onset of acidification. By contrast, in neutrophils cultured for 2 hours in the presence of G-CSF, the amount of the 57-kD subunit was similar to that in freshly isolated neutrophils. However, inhibition of protein synthesis with cycloheximide and actinomycin D led to loss of the 57-kD subunit even in the presence of G-CSF. These results indicated that ongoing protein synthesis was required to maintain the v-ATPase, and further suggested that G-CSF acted, at least in part, by maintaining synthesis of the 57-kD cytosolic subunit. G-CSF also promoted the translocation of the 57-and 33-kD cytosolic v-ATPase subunits to the membrane. Our findings suggested two coordinate mechanisms by which the activity of the v-ATPase could be increased by G-CSF: the synthesis of cytosolic v-ATPase subunits and their translocation to the membrane.
- Published
- 1997
19. Fibrinogen heterogeneity in homozygous plasminogen deficiency type I: further evidence that plasmin is not involved in formation of LMW- and LMW'-fibrinogen
- Author
-
C E, Dempfle, S A, Pfitzner, D, Schott, K H, Niessen, and D L, Heene
- Subjects
Male ,Genetic Carrier Screening ,Homozygote ,Immunoblotting ,Fibrinogen ,Infant ,Plasminogen ,Molecular Weight ,Alternative Splicing ,Consanguinity ,Reference Values ,Humans ,Female ,Dimerization - Abstract
Human plasma fibrinogen is heterogeneous in SDS-polyacrylamide gel electrophoresis and other methods for separation of proteins by molecular size. A high molecular weight fraction (HMW-fibrinogen, 340 kD) contributes approximately 50% of total fibrinogen antigen. Low molecular weight fibrinogen (LMW-fibrinogen, 300 kD) adds another 40%. The residual amount is LMW'-fibrinogen with a molecular weight of 280 kD, and a small amount of very high molecular weight fibrinogen (Fib420), the product of alternative splicing of the A alpha-chain genetic information, resulting in an extended A alpha-chain C-terminus. Fibrinogen was detected by specific immunostaining of nonreduced SDS-PAGE gel immunoblots with antibodies against fibrinopeptide A. Using densitometric scans of the immunoblots we found a ratio of HMW-, LMW- and LMW'-fibrinogen in a patient with homozygous plasminogen deficiency that was similar to the ratio found in immunoblots of plasma from healthy blood donors. Treatment with plasminogen concentrate resulted in a slight decrease of the proportion of HMW-fibrinogen, followed by an increase to 78%. The LMW'-fibrinogen band gained intensity initially, increasing to 11.9% of fibrinogen antigen 6 h after starting plasminogen infusion, but then dropped to levels below detection limit of the immunoblotting assay. LMW-fibrinogen remained constant during the initial 72 h of plasminogen treatment, then dropping to values in the range of 22-25% afterwards. The proportion of HMW-, LMW-, and LMW'-fibrinogen again reached the initial levels two weeks after starting treatment with plasminogen concentrate. We conclude that plasminogen is not involved in the limited proteolysis leading to formation of LMW-fibrinogen and LMW'-fibrinogen in the absence of a generalized fibrinolytic condition. Fibrinolytic activation may lead to the formation of fibrinogen degradation product X, which appears in a similar position as LMW'-fibrinogen in SDS-PAGE.
- Published
- 1997
20. [Chlorinated carbohydrate content of fetal and pediatric organs and tissues]
- Author
-
U, Bosse, N, Bannert, K H, Niessen, M, Teufel, and I, Röse
- Subjects
Brain Chemistry ,Insecticides ,Muscles ,Myocardium ,Placenta ,Infant, Newborn ,Brain ,Infant ,Thymus Gland ,Kidney ,Polychlorinated Biphenyls ,DDT ,Heptachlor ,Fetus ,Adipose Tissue ,Liver ,Child, Preschool ,Hydrocarbons, Chlorinated ,Humans ,Tissue Distribution ,Child ,Lung ,Hexachlorocyclohexane - Abstract
Organic halogens are used as pesticides and in chemical industries. They are secreted with breast milk and accumulated in fat tissue of infants. Organic halogens can be found already in newborns. We analysed polychlorinated biphenyl (PCB), DDT, hexachlorocyclohexane (HCH), and heptachlor in subcutaneous fat tissue and other tissues (placenta, liver, kidney, lung, brain, thymus, muscle, heart) of 34 fetuses and dead children. These substances were found regularly in placenta, in fetal subcutaneous fat tissue and in fetal organs. They therefore can influence possibly early and sensitive stages of intrauterine development. The average concentrations found in fetal fat tissue were: PCB 0.7 mg/kg fat tissue, DDT 0.7 mg/kg, HCH 0.14 mg/kg, and heptachlor 0.03 mg/kg.
- Published
- 1996
21. A comparison of the concentrations of certain chlorinated hydrocarbons and polychlorinated biphenyls in bone marrow and fat tissue of children and their concentrations in breast milk
- Author
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J, Scheele, M, Teufel, and K H, Niessen
- Subjects
Adipose Tissue ,Milk, Human ,Bone Marrow ,Hydrocarbons, Chlorinated ,Humans ,Child ,Polychlorinated Biphenyls - Abstract
Chlorinated hydrocarbon (CHC) and polychlorinated biphenyl (PCB) concentrations in the bone marrow of 57 children were compared with the concentrations in adipose tissue of 50 children and the concentrations in breast milk in the Federal Republic of Germany from 1984 to 1991. The concentrations of hexachlorobenzene (HCB), the dichlorodiphenyltrichloroethane (DDT)-metabolites, and polychlorinated biphenyl (PCB) congeners no. 138 and no. 153 were increased threefold, while the concentrations of several hexachloro-cyclohexane (HCH)-isomers and PCB congener no. 180 were only increased twofold. Because breast feeding is the primary source of CHC and PCB in toddlers and infants we also compared the concentrations in bone marrow of children with the concentrations in breast milk and found approximately fourfold higher concentrations for the most highly chlorinated PCB congener no. 180, but only threefold higher concentration for PCB 138 and 153 and the DDT-metabolites. The concentrations of beta-HCH and HCB were only slightly higher in bone marrow.
- Published
- 1995
22. Ichthyosis, spastische Diplegie und mentale Retardierung
- Author
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I. Treiss, S. König, W. Kölfen, B. Bayerl, and K.-H. Niessen✝
- Subjects
medicine.medical_specialty ,Pediatrics ,business.industry ,Pediatrics, Perinatology and Child Health ,Pediatric surgery ,Child and adolescent psychiatry ,medicine ,Surgery ,business - Published
- 2003
- Full Text
- View/download PDF
23. [Simultaneous determination of inorganic anions in body fluids. A new method in pediatric laboratory diagnosis--results of a pilot study]
- Author
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I, Böhn, K H, Niessen, F, Reineke, and M, Teufel
- Subjects
Anions ,Bromides ,Male ,Nitrates ,Adolescent ,Sulfates ,Infant, Newborn ,Infant ,Pilot Projects ,Signal Processing, Computer-Assisted ,Chromatography, Ion Exchange ,Body Fluids ,Phosphates ,Child Development ,Chlorides ,Reference Values ,Child, Preschool ,Humans ,Female ,Child - Abstract
The anions analysis was a methodical problem up to now. This was the reason for low interest. Biological fluids like saliva and urine which could easily receive without any stress for the children, are little investigated for its capacity on nitrite, nitrate, bromide and sulfate. In this performance there will presented an ion-chromatographic method to determine inorganic anions in the following body-fluids: serum saliva, liquor and urine. The anions chloride, nitrite, bromide, nitrate, phosphate and sulfate was determined quantitatively. The method was proved in a pilot-study on children's body-fluids serum, liquor and saliva. The objects was to get a landmark in expectation from anion concentrations. Bromide was detected as a constant part in all body fluids. The origin and importance is not clear till now. Also was found nitrate in all investigated body fluids. There seems to be a connection between diarrhea and an increase in serum levels from nitrate. We found considerable amounts of nitrate in saliva by babies and infants. The method is distinguished by little fluctuation in measurement and high specificity. Short time in analysis and simple handling will do the method for a qualified one in pediatrics.
- Published
- 1994
24. A pilot study on polychlorinated biphenyl levels in the bone marrow of healthy individuals and leukemia patients
- Author
-
J, Scheele, M, Teufel, and K H, Niessen
- Subjects
Adult ,Aged, 80 and over ,Male ,Chromatography, Gas ,Leukemia ,Pilot Projects ,Middle Aged ,Hodgkin Disease ,Polychlorinated Biphenyls ,Bone Marrow ,Humans ,Female ,Child ,Aged ,Plasmacytoma - Abstract
In this pilot study the concentrations of polychlorinated biphenyls (PCBs) was determined by capillary column gas chromatography in bone marrow from 29 adults. The highest concentration in all adult individuals was detected for PCB no. 180 (mean = 0.991) followed by two other highly chlorinated PCBs, no. 153 (mean = 0.918) and no. 138 (mean = 0.927). The less chlorinated PCBs, no. 101 (mean = 0.255), no. 52 (mean = 0.161), and no. 28 (mean = 0.324) contributed to a lesser extent. Additional samples from children (N = 19) were used to assess the dependence of PCB concentrations on patient age (Scheele et al. Eur J Pediatr 1992; 151:802-805). When comparing the data of adult leukemia and lymphoma patients with a reference group of healthy adult individuals, no significant increase in the leukemia patients was found.
- Published
- 1994
25. Chlorinated hydrocarbons in the bone marrow of children: studies on their association with leukaemia
- Author
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M. Teufel, K. H. Niessen, and J. Scheele
- Subjects
medicine.medical_specialty ,Hexachlorocyclohexane ,Precursor Cell Lymphoblastic Leukemia Lymphoma ,chemistry.chemical_compound ,Dieldrin ,Animal science ,Capillary column ,Bone Marrow ,Internal medicine ,medicine ,Hydrocarbons, Chlorinated ,Humans ,Pesticides ,Child ,business.industry ,Hexachlorobenzene ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Polychlorinated Biphenyls ,Leukemia ,Leukemia, Myeloid, Acute ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Bone marrow ,Gas chromatography ,business - Abstract
Concentrations of chlorinated hydrocarbons and polychlorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean = 3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.
- Published
- 1992
26. [Exposure of our children to pesticides, PCB and potentially critical anions]
- Author
-
M, Teufel, I, Böhn, and K H, Niessen
- Subjects
Adipose Tissue ,Milk, Human ,Risk Factors ,Child, Preschool ,Infant, Newborn ,Body Burden ,Humans ,Infant ,Environmental Pollutants ,Pesticides ,Child ,Polychlorinated Biphenyls - Abstract
Among environmental pollutants the organohalogens still play an important role since they accumulate in human fat tissue and are secreted with mother's milk during lactation. Fortunately DDT-, HCH- and HCB-levels decreased in breast milk during the last years. In contrast, the PCB concentrations were still three-to five-fold above the permitted limits for cow's milk. Fat tissue of 262 newborns, infants and children was already as severely loaded with organohalogens as human milk. However, children with malignant tumors or congenital malformations did not show elevated concentrations in fat tissue. The significance of the potentially critical anions such as nitrate, nitrite, bromide, sulfate for the health of our children needs further clarification.
- Published
- 1991
27. Chlorinated hydrocarbons in fat tissue: analyses of residues in healthy children, tumor patients, and malformed children
- Author
-
Karl-Ludwig Waag, H. Lochbühler, M. Teufel, W. Brands, K. H. Niessen, G. V. Oelsnitz, P. Schweizer, and J. Sartoris
- Subjects
medicine.medical_specialty ,Adolescent ,Heptachlor ,Health, Toxicology and Mutagenesis ,Adipose tissue ,Toxicology ,West germany ,Congenital Abnormalities ,Dieldrin ,chemistry.chemical_compound ,Capillary column ,Internal medicine ,Neoplasms ,medicine ,Hydrocarbons, Chlorinated ,Humans ,Child ,biology ,Infant, Newborn ,Infant ,Congenital malformations ,General Medicine ,biology.organism_classification ,Pollution ,Endocrinology ,chemistry ,Adipose Tissue ,Tasa ,Child, Preschool ,Toxicity - Abstract
The content of chlorinated hydrocarbons (CHC) was determined by means of capillary column gas chromatography in samples of fat tissue from 183 healthy children, 46 children with malignant tumors and 33 children with benign tumors or congenital malformations. The highest concentrations were found for total polychlorobiphenyls (PCB) (mean = 1.614 ppm), followed by the DDT group (mean = 0.556 ppm, HCB (mean = 0.097 ppm), the HCH isomers (mean = 0.083 ppm), dieldrin (mean = 0.020 ppm) and total heptachlor (mean = 0.010 ppm). Neonates displayed high concentrations in the adipose tissue before the first uptake of food. In the first six months of life, the concentrations of total PCB, the individual PCB components as well as DDT and HCB decreased significantly. In the second year of life, they rose again to the initial values and then remained relatively constant during the rest of childhood. The regional differences with regard to total CHC residues were slight, so that the CHC exposure cannot be reduced by a change of domicile within West Germany (FRG). Children with congenital malformations or benign or malignant tumors do not display raised concentrations of CHC.
- Published
- 1990
28. The Effects of C1-esterase Inhibition on Cerebral Immune Activation in a Model of Cerebral Embolization in the Rat
- Author
-
JM, Dieleman, primary, F, De Lange, additional, N, Diaz, additional, H, Niessen, additional, E, Hack, additional, and CJ, Kalkman, additional
- Published
- 2004
- Full Text
- View/download PDF
29. Methane from synthesis gas and operation of high-temperature methanation
- Author
-
J. Range, H. Niessen, H. J. R. Schiebahn, B. Höhlein, and M. Vorwerk
- Subjects
Nuclear and High Energy Physics ,medicine.medical_specialty ,Substitute natural gas ,Materials science ,Waste management ,business.industry ,Mechanical Engineering ,Carbochemistry ,Heat capacity ,Methane ,chemistry.chemical_compound ,Pilot plant ,Nuclear Energy and Engineering ,chemistry ,Methanation ,medicine ,General Materials Science ,Coal ,Safety, Risk, Reliability and Quality ,business ,Waste Management and Disposal ,Syngas - Abstract
The methanation process is an important unit in generating substitute natural gas (SNG) from coal and in providing heat in the Long-Distance Nuclear Energy Transport (NFE) system. Procedures for methanizing synthesis gases containing CO, CO2 and H2 have been developed and tested at the Kernforschungsanlage Julich GmbH (KFA - Federal Republic of Germany) since 1976. This is being carried out together with the partner in the NFE Project, Rheinische Braunkohlenwerke AG, Cologne (FRG). It has been demonstrated in several thousand operating hours at the KFA since 1979 that the procedures and components developed, as well as the catalysts employed satisfy the demands made by high-temperature methanation in the three-stage methanation plants ADAM I and ADAM II with a SNG gas production of 200 or 3300 m3 (STP)h−1 and a useful heat capacity of 300 kJ/s or 5.8 MJ/s. In 1981 a single-stage pilot plant was put into operation at the KFA in which one reactor with cooled stepped reaction tubes and catalytic fixed beds was utilized. The test operation of 1100 hours shows that at a high gas load on the reaction tubes, thermodynamic equilibrium with a high methane content in the product gas can be achieved with simultaneous steam production at 100 bar.
- Published
- 1984
- Full Text
- View/download PDF
30. Spätergebnisse nach partieller und totaler Colektomie im Säuglingsalter
- Author
-
K H Niessen, M Teufel, J Kleeberg, A Flach, and P Reifferscheid
- Subjects
Enterocolitis ,medicine.medical_specialty ,Aldosterone ,business.industry ,medicine.medical_treatment ,Bone age ,Gastroenterology ,chemistry.chemical_compound ,Postprandial ,chemistry ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,medicine.symptom ,business ,Flatulence ,Neurotensin ,Colectomy ,Gastrin - Abstract
26 children were investigated on an average 11.5 years after partial (n = 13) and total (n = 13) colonic resection. Total colectomy was followed by an increased frequency of gastrointestinal symptoms such as recurrent abdominal pain, flatulence, attacks of diarrhoea, frequent and pasty or liquid stools with strange smell. An increased salt or fluid intake was observed in one half of these patients. Their height and bone age was slightly but significantly reduced. Laboratory investigations revealed no significant deficiencies of electrolyts, vitamins or trace elements. However Renin (mean and 2s-range = 5.2; 2.7-6.8 ng/ml.h, normal values (NV) 1.3; 0.5-4.0 ng/ml.h, p less than 0.02), aldosterone (242.1; 168.4-357.8 pg/ml, NV 78.9; 39.4-168.4 pg/ml, *p less than 0.02), conjugated bile acids (11.3; 5.2-20.0 mumol/1, NV 4.2; 1.5-7.0 mumol/1, p less than 0.01) and serum urea concentration (32.5; 20.8-48.7 mg/dl, NV 14.6; 6.0-22.5 mg/dl, p less than 0.01) were significantly elevated. Three postprandial plasma levels of gastrin, VIP and neurotensin were within normal limits. In patients with partial large bowel resection all signs were less pronounced. According to our results a special diet in children years after colectomy seems not to be required.
- Published
- 1988
- Full Text
- View/download PDF
31. Zur Bedeutung niederosmolarer Diäten für den oralen Nahrungsaufbau bei schwerster Malabsorption - Klinische Beobachtungen am Beispiel subtotal dünndarmresezierter Säuglinge
- Author
-
M Teufel and K H Niessen
- Subjects
medicine.medical_specialty ,Small bowel resection ,Malabsorption ,medicine.medical_treatment ,digestive, oral, and skin physiology ,Bowel resection ,Biology ,Short bowel syndrome ,medicine.disease ,Gastroenterology ,Intestinal absorption ,Absorption rate ,Internal medicine ,Food supply ,Pediatrics, Perinatology and Child Health ,medicine ,Malabsorption syndromes - Abstract
Regenerative and adaptive processes of the gut are apparently analogous to the absorption rate in small bowel diseases. These processes can be enhanced by the prolongation of passage time which, in turn, is influenced by the osmolality of the formula diet. Since infants who have undergone a subtotal bowel resection, like other children with serious diseases of the small bowel, are extraordinarily sensitive to hyperosmolar food, any preparation with special indications should be balanced and rendered hypoosmolar in full caloric concentration. Such formulas may well facilitate food supply to infants and, in case of short bowel syndrome, encourage more pronounced morphologic adaptation.
- Published
- 1984
- Full Text
- View/download PDF
32. Oligosymptomatische Zöliakie - Achsenkorrektur eines extremen X-Beines unter gliadinfreier Kost
- Author
-
M Teufel, K H Niessen, and A Bernau
- Subjects
medicine.medical_specialty ,Osteomalacia ,Malabsorption ,business.industry ,Diet therapy ,medicine.medical_treatment ,nutritional and metabolic diseases ,medicine.disease ,Osteotomy ,Coeliac disease ,Genu Valgum ,Surgery ,Pediatrics, Perinatology and Child Health ,Orthopedic surgery ,Medicine ,Enteropathy ,business - Abstract
We report on a girl who suffered from a severe left-sided Genu valgum. As there was a remarkable deterioration despite a conservative orthopedic therapy on osteotomy was planned. However, preoperative investigations revealed a malabsorption syndrome with osteomalacia due to coeliac disease. This gliadin-sensitive enteropathy had already been diagnosed and treated in infancy but had been ignored, since no abdominal symptoms had occurred after re-introduction of normal food. Four years after start of gliadin-free diet the false position of the left leg had disappeared and an operative correction had not to be performed.
- Published
- 1987
- Full Text
- View/download PDF
33. Anämischer Leberinfarkt nach stumpfem Bauchtrauma
- Author
-
H Fischbach, K H Niessen, M Teufel, and P Reifferscheid
- Subjects
medicine.medical_specialty ,business.industry ,Left lobe ,Infarction ,medicine.disease ,Surgery ,Resection ,Blunt ,Abdominal trauma ,Pediatrics, Perinatology and Child Health ,medicine ,Blood supply ,Collateral vessels ,Anemic infarct ,business - Abstract
Particularly in childhood, ischaemias of the liver are very rare. This is due to numerous collateral vessels and a dual blood supply of the liver. We, therefore, report on a 2-year old boy who suffered from an anaemic infarction of the whole left lobe of the liver after a fall. The clinical course and findings, including histology, are described. After resection of the left lobe the boy was free of symptoms.
- Published
- 1985
- Full Text
- View/download PDF
34. Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate.
- Author
-
H, Niessen, H, Harz, P, Bedner, K, Krmer, and K, Willecke
- Abstract
Intercellular propagation of signals through connexin32-containing gap junctions is of major importance in physiological processes like nerve activity-dependent glucose mobilization in liver parenchymal cells and enzyme secretion from pancreatic acinar cells. In these cells, as in other organs, more than one type of connexin is expressed. We hypothesized that different permeabilities towards second messenger molecules could be one of the reasons for connexin diversity. In order to investigate this, we analyzed transmission of inositol 1,4,5-trisphosphate-mediated calcium waves in FURA-2-loaded monolayers of human HeLa cells expressing murine connexin26, -32 or -43. Gap junction-mediated cell coupling in different connexin-transfected HeLa cells was standardized by measuring the spreading of microinjected Mn(2+) that led to local quenching of FURA-2 fluorescence. Microinjection of inositol 1,4,5-trisphosphate into confluently growing HeLa connexin32 transfectants induced propagation of a Ca(2+) wave from the injected cell to neighboring cells that was at least three- to fourfold more efficient than in HeLa Cx26 cells and about 2.5-fold more efficient than in HeLa Cx43 transfectants. Our results support the notion that diffusion of inositol 1,4,5-trisphosphate through connexin32-containing gap junctions is essential for the optimal physiological response, for example by recruiting liver parenchymal cells that contain subthreshold levels of this short lived second messenger.
- Published
- 2000
35. �ber Vorkommen von Sulfoniumverbindungen in Metasystox (i) und Metasystox R und ihre physiologische Wirkung
- Author
-
H. Niessen, G. Kimmerle, G. Hecht, and H. Tietz
- Subjects
Chemistry ,Health, Toxicology and Mutagenesis ,Pharmacology toxicology ,General Medicine ,Toxicology ,Molecular biology - Abstract
0,0-Dimethyl-S-athylsulfonioathylmethylthiolphosphat (III) wurde in Metasystox (i) und Metasystox R nachgewiesen und durch Vergleich mit dem synthetisch dargestellten Methylsulfat von III identifiziert. Es wird eine Analysenmethode beschrieben, die die quantitative Erfassung geringer Mengen von III in Metasystox (i) und Metasystox R gestattet. Proben beider Insecticide wurden unter verschiedenen Bedingungen gelagert und anschliesend der Gehalt an III bestimmt. Die Analysenergebnisse sowie toxikologische Untersuchungen wasriger Metasystox (i)-Emulsionen und des Methylsulfats von III ergaben keinen Anhaltspunkt fur die Annahme, das beim Ansetzen und Ausbringen der Spritzbruhe von Metasystox (i) und Metasystox R gesundheitliche Schadigungen durch physiologisch aktive Sulfoniumverbindungen zu befurchten sind.
- Published
- 1963
- Full Text
- View/download PDF
36. Results of a new method for the repair of inguinal hernia
- Author
-
H. Niessen and W.J. Potts
- Subjects
Gubernaculum ,business.industry ,Forceps ,General Medicine ,Anatomy ,DIRECT HERNIA ,medicine.disease ,Inferior pole ,Raising (metalworking) ,Inguinal hernia ,medicine.anatomical_structure ,Scrotum ,medicine ,Surgery ,business - Abstract
method, but rather as an aid in seIected cases. The principle of Schmieden’s method is embodied in a scheme of transpIanting the cord to a newIy made interna inguina1 ring in the obIique and transversalis muscles at the outer edge of the rectus. This transpIantation, made possibIe onIy by raising the testicIe out of the scrotum, aIIows a compIete and soIid cIosure of the entire inguina1 floor. Many recurrences appear at the site of the interna ring, and to eIiminate these this new operation was devised. This report is concerned with a foIIow-up study of 102 cases operated upon by this technique between January, 1929 and December, 1930 in the Frankfort CIinic. being extended we11 above the internal ring. The media1 Ieaf is caught with two forceps and retracted upward to expose the underIying muscIes. The cord is then freed from its bed and the testicIe sIowIy drawn from the scrotum. AI1 bIeeders, even the tiniest, are carefuIIy tied off as they are exposed. The gubernaculum of Hunter, usuaIIy present as a weII-defined fibrous strand at the inferior pole of the testicIe, is doubly tied and cut, the Iigatures being Ieft Iong to permit repair at thecIose of the operation. A wet compress is pIaced in the scrotum. Raising the testicIe out of the scrotum is an essentia1 step in the operation, and, aIthough a somewhat radica1 procedure, permits more carefu1 and c6mpIete separation of the sac and its Iigation high in the inguina1 cana1. Furthermore, it makes possibIe a more thorough inspection of the inguina1 triangIe for direct hernia, and an unobstructed view whiIe making the repair. The sac is deaIt with in the usua1 manner. A 2 to 3 cm. strip in the interna obIique
- Published
- 1932
- Full Text
- View/download PDF
37. Die Analyse von Pflanzenschutzmittelrückständen
- Author
-
H. Niessen and H. Frehse
- Subjects
Management science ,Chemistry ,business.industry ,Clinical Biochemistry ,Medical laboratory ,General Materials Science ,Analytical Chemistry (journal) ,General Medicine ,business ,Analytical Chemistry - Published
- 1962
- Full Text
- View/download PDF
38. Untersuchungen zur Frage der Pankreasadaptation bei S�uglingen und Kindern nach subtotaler D�nndarmresektion
- Author
-
A. Flach, Schmidt K, K. H. Niessen, Osswald P, and G. Brügmann
- Subjects
Gynecology ,medicine.medical_specialty ,Small bowel resection ,medicine.anatomical_structure ,business.industry ,Drug Discovery ,medicine ,Molecular Medicine ,General Medicine ,Pancreas ,business ,Genetics (clinical) - Abstract
Bei 4 Kindern wurde nach einer subtotalen Dunndarmresektion die Pankreasfunktion untersucht (in 3 Fallen zweimal). Die Ergebnisse wurden mit den Werten von 33 Pankreas-gesunden Sauglingen und Kindern verglichen. 2 Patienten zeigten eine vermehrte Sekretion und Bikarbonatausschuttung, einer von ihnen zusatzlich eine erhohte Trypsinaktivitat im Darmsaft. Es wird vermutet, das die Ursache dieser Pankreas-Hyperfunktion die gleiche ist wie bei den ebenfalls stark unterernahrten Patienten mit florider Coliakie.
- Published
- 1974
- Full Text
- View/download PDF
39. Papierchromatographische trennung aromatischer phosphorsäureester-insektizide
- Author
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H. Niessen, H. Tietz, and H. Frehse
- Subjects
Chromatography ,chemistry ,Phosphorus ,Organic Chemistry ,medicine ,chemistry.chemical_element ,General Medicine ,medicine.disease ,Biochemistry ,Organophosphate poisoning ,Analytical Chemistry - Published
- 1962
- Full Text
- View/download PDF
40. [Crohn disease: initial experiences with cyclosporin A in an adolescent girl]
- Author
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G, Dannecker, H, Malchow, K H, Niessen, and M B, Ranke
- Subjects
Sulfasalazine ,Adolescent ,Crohn Disease ,Lymphoma ,Prednisolone ,Azathioprine ,Humans ,Osteoporosis ,Cyclosporins ,Female - Abstract
The diagnosis of Crohn's disease with extensive involvement of small intestine and colon was first made in a 12 3/4-year-old girl, now 15 1/2 years old. Despite continued treatment with prednisolone and salazosulfapyridine, as well as azathioprine and metronidazole, no lasting remission was obtained. Widespread severe osteoporosis with vertebral fractures made it necessary to discontinue the prednisolone, despite endoscopically and biochemically confirmed signs of activity of the disease. Administration of cyclosporin A in this situation produced phases of improved clinical and biochemical parameters. Regular control of biochemical levels failed to reveal any drug-specific acute side-effects. Because of the increased incidence of malignant lymphoma under cyclosporin A this drug should be held in reserve in the treatment of Crohn's disease, until results from controlled studies have become available.
- Published
- 1985
41. Interactive Control and Data Processing in Multichannel SQUID Instrumentation Systems
- Author
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A. J. van der Wal, R. M. H. Niessen, and J. H. Voskamp
- Subjects
Data processing ,Squid ,Software ,biology ,business.industry ,Computer science ,Embedded system ,Interactive control ,biology.animal ,Instrumentation (computer programming) ,Architecture ,business - Abstract
In the present article the architecture of a computer-controlled system for the acquisition and processing of signals and the simultaneous display of results is described for use in multichannel magneto-encephalography (MEG) experiments. It is shown that by selecting this architecture, that includes both state-of-the-art hardware concepts and interactive real-time software, a system has been developed that offers the combination of high performance and easy modifiability to the experiment.
- Published
- 1989
- Full Text
- View/download PDF
42. [Disaccharidases of the small intestine mucosa in infants and children. 'Normal values', log normal distribution and age dependence]
- Author
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K H, Niessen, K, Schmidt, and G, Brügmann
- Subjects
Intestinal Diseases ,Histocytochemistry ,Biopsy ,Child, Preschool ,Intestine, Small ,Age Factors ,Humans ,Infant ,Intestinal Mucosa ,Child ,Disaccharidases - Abstract
In 63 infants and children with a histological normal mucosa of the duodenum, without an isolated defect of enzyme and with a normal increase of xylose and glucose in serum after a combined xylose-lactose loading test the activities of disaccharidases were log normal distributed. The asymmetric distributions were transformed into symmetric ones and the geometric mean (x) as well as the range (+/- 2 s) of maltase, saccharase, isomaltase, lactase and trehalase were calculated. Only the activity of lactase shows a significant dependency on age. In the first year of age the lower limit (x -- 2 s) of this enzyme is much higher than later.
- Published
- 1975
43. Studies on the cause of hyperuricosuria in cystic fibrosis patients
- Author
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K H Niessen and A Wolf
- Subjects
Purine ,medicine.medical_specialty ,Adolescent ,Cystic Fibrosis ,Urinary system ,Allopurinol ,Urine ,Cystic fibrosis ,chemistry.chemical_compound ,Internal medicine ,medicine ,Ingestion ,Humans ,Child ,Hypoxanthine ,business.industry ,Gastroenterology ,Hyperuricosuria ,medicine.disease ,Uric Acid ,Endocrinology ,chemistry ,Purines ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Pancreatin ,business ,medicine.drug - Abstract
Qualitative and quantitative analyses of the purine contents of 24 pancreatic enzyme preparations currently available in the Federal Republic of Germany were carried out; guanine, adenine, and hypoxanthine were demonstrated in all drugs examined. The contamination level per dosage unit ranged from 2 to 10 mg urate equivalents, which, after purine absorption and metabolism, must be excreted by the kidneys. Although the additional daily urate intake through the ingestion of pancreatic enzyme preparations was less than 70 mg in 16 of 18 cystic fibrosis patients, uric acid excretion was astoundingly high. Compared to the amount of urate excreted in the urine over a 24-h period, urate intake through pancreatic enzyme preparations was so low that these drugs do not represent an important contributing factor for hyperuricosuria. A clear-cut relationship could be demonstrated between the urinary urate concentration and the severity of the disease. The increased catabolism of these patients therefore is more likely the real cause of the hyperuricosuria demonstrable in most cases. Increased fluid intake and administration of allopurinol proved to be an extremely effective means of controlling hyperuricosuria; no side effects were observed.
- Published
- 1982
44. [The application of a combined Xylose-lactose tolerance-test in children with suspected malabsorption (author's transl)]
- Author
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G, Brügmann, K H, Niessen, K, Schmidt, and D, Höntzsch
- Subjects
Blood Glucose ,Lactose Intolerance ,Xylose ,Malabsorption Syndromes ,Duodenum ,Biopsy ,Lactose Tolerance Test ,Humans ,Child - Abstract
A combined xylose-lactose tolerance-test and a duodenal biopsy were performed in 68 children with suspected malabsorption-syndrome. The purpose of the present work was to assess the diagnostic value of xylose concentrations in blood at different times and to determine the additional discriminatory value to glucose levels. The contribution of the glucose rise to a calculated discriminant function is statistically significant but practically negligible and therefore does not justify its determination. A small-bowel biopsy is recommended if the concentration of xylose after 60 min is less than 26 mg/100 ml or the increment of xylose concentration above fasting level is 18 mg/100 ml or less.
- Published
- 1976
45. [Diagnosis and therapy of congenital and acquired disaccharidase deficiency of the intestinal mucosa]
- Author
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K H, Niessen, G, Brügmann, and K, Schmidt
- Subjects
Blood Glucose ,Lactose Intolerance ,Child, Preschool ,Intestine, Small ,Lactose Tolerance Test ,Humans ,Infant ,Intestinal Mucosa ,Deficiency Diseases ,Disaccharidases ,Nutrition Disorders - Published
- 1975
46. [Insufficiency of the exocrine pancreas in Wilson's disease (author's transl)]
- Author
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P, Osswald and K H, Niessen
- Subjects
Adult ,Male ,Hepatolenticular Degeneration ,Penicillamine ,Ceruloplasmin ,Chymotrypsin ,Humans ,Pancreatic Diseases ,Trypsin ,Child ,Lysosomes ,Pancreas ,Copper - Abstract
The function of the exocrine pancreas was examined by the secretin-pancreozymin-test in 3 patients with Wilson's disease. In all cases we found a partial insufficiency. At the time of investigation the patients were 6(7)/12, 11(6)/12 and 21 years old. The youngest one was examined before therapy with D-Penicillamin. We suppose that storage of copper in lysosomes causes a cytotoxic damage of the exocrine part of the pancreas requiring substitution therapy in advanced cases.
- Published
- 1976
47. [Exocrine pancreas insufficiency without mucoviscidosis in infancy and early childhood]
- Author
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K H, Niessen, P, Osswald, K, Schmidt, F, Hartmann, E, Droste, and G, Brügmann
- Subjects
Male ,Cystic Fibrosis ,Secretin ,Body Weight ,Age Factors ,Humans ,Infant ,Pancreatic Diseases ,Female ,Child ,Cholecystokinin ,Pancreas ,Body Height - Published
- 1974
48. [Diseases of the exocrine pancreas in infants and children. A review. 3. Pseudocysts, cysts, tumors: functional disorders of the exocrine pancreas secretion; pseudo-pancreatic insufficiency]
- Author
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K H, Niessen
- Subjects
Male ,Carcinoma ,Cystadenoma ,Infant ,Pancreatic Diseases ,Adenoma, Islet Cell ,Bile Acids and Salts ,Pancreatic Neoplasms ,Zollinger-Ellison Syndrome ,Child, Preschool ,Humans ,Female ,Pancreatic Cyst ,Child ,Pancreas ,Peptide Hydrolases ,Ultrasonography - Abstract
The aim of the present work is to provide a new classification of the exocrine pancreatic diseases in childhood by means of a simple and practicable scheme which is in line with the recognized classification of Internal Medicine. The article presents a definite distinction between organic diseases of the pancreas -- such as deformities, congenital insufficiences, pancreatitis, cysts and tumors -- functional disturbances of the pancreas secretion and pseudo-pancreas insufficiency caused by extrapancreatic factors. New investigative methods help to distinguish between various disorders encountered.
- Published
- 1980
49. [Bile acids in duodenal juice of infants and children. Normal values, lognormal distribution, and age-dependence of the total quantity and the distribution of bile acids (author's transl)]
- Author
-
K H, Niessen
- Subjects
Bile Acids and Salts ,Intestinal Secretions ,Secretin ,Reference Values ,Child, Preschool ,Body Weight ,Age Factors ,Humans ,Infant ,Child ,Cholecystokinin - Abstract
43 gastroenterologically healthy infants and children were investigated during the basic secretion period and after the injection of secretin/pankreozymin in order to establish the total quantity and also the distribution of the secreted bile acids. The total concentration and quantity were enzymatically determined while column and thin-layer chromatography were utilized to separate the bile into 34 different bile acids. Quantified results for bile salts were read directly from the thin-layer sheet with the help of a Chromatogram-Spectrophotometer Zeiss KM 3. While the total quantity of bile acids was found to be independent of age, the composition of bile changed during the first years of life. The percentage of cholic acids decreased from 50% in infants to 35% in older children. At the same time, deoxycholic acids went up from 3% to 13%, and chenodeoxycholic acids increased by 5%. The percentage of glycine and taurine conjugated bile salts, however, remained constant after to the second month of life, the former at 58% and the latter at 35%. In comparison, rather small amounts of unconjugated acids and sulfates were secreted, 0,5% and 6% respectively. The latter were distributed in the same sequence as the nonsulfated bile acids. Lithocholic acids (2,6%) and ursodeoxycholic acids (4,3%) were regularly present in the intestinal secretion.
- Published
- 1979
50. Die Probleme der Parenteralen Ernährung und des Nahrungsaufbaues in der Kinderchirurgie
- Author
-
A. Flach, K. H. Niessen, and Bähr R
- Abstract
Bei chirurgischen Erkrankungen im Neugeborenen-, Sauglings- und Kindesalter mussen folgende Fakten, die sich aus funktionellen Besonderheiten der Physiologie des Wasser-Elektrolyt- und Energiehaushaltes in dieser fruhen Lebensperiode ergeben, besonders beachtet werden: 1. Der Kalorienbedarf des Neugeborenen und Sauglings ist relativ hoch, er betragt im ersten Lebensvierteljahr 110 bis 130 Kalorien, beim Erwachsenen 30 bis 40 Kalorien pro kg Korpergewicht und Tag. 2. Der Flussigkeitsbedarf ist um so groser, je junger das Kind ist. Beim Saugling werden pro Tag und pro kg Korpergewicht 160 bis 200 ml benotigt. Dies entspricht 15 bis 20 % des Korpergewichtes, beim Erwachsenen sind es 2 bis 4 %. Die Grunde hierfur sind hoher Grundumsatz durch Wachstum, rascher Flussigkeitsaustausch und relativ grose Korperoberflache pro kg Korpergewicht. Auserdem kommt eine Unreife der renalen, neurosekretorischen und kardiovaskularen Regulationssysteme hinzu, so das beim Saugling sehr rasch Wasser- und Elektrolytdefizite auftreten, die um so schlechter kompensiert werden, je junger das Kind ist (16, 17) 3. Der Eiweisbedarf des Sauglings betragt 3 bis 4 g, beim Erwachsenen 1 g pro kg Korpergewicht und Tag. 4. Neugeborene haben in den ersten Lebenstagen so lange eine katabole Stoffwechsellage, bis ausreichende Nahrungsmengen oral verabreicht werden konnen. Wird diese Tatsache bei gesunden Kindern als „physiologisch“ angesehen, so ergibt sich daraus fur Fruhgeburten mit niedrigem Geburtsgewicht und Trinkschwache sowie bei Kindern, bei denen eine orale Kalorienzufuhr beispielsweise nach einer Operation des Magen-Darm-Traktes nicht moglich ist, sowie Kindern mit erheblich gesteigertem Kalorienbedarf — als Beispiele seien genannt das Schadel-Hirn-Trauma oder der Tetanus - ein lebensbedrohlicher Zustand, da die Energiereserven auserst gering sind (17, 30).
- Published
- 1978
- Full Text
- View/download PDF
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