134 results on '"H. Kadota"'
Search Results
2. Development of a 3D visualization system for the cerebral aneurysm coil embolization
- Author
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M. Sisibori, H. Kadota, Nobuaki Yamamoto, M. Oono, M. Ishihara, Yasuhisa Kanematsu, R. Morigaki, and S. Fujisawa
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2d images ,DICOM ,Catheter ,Aneurysm ,Computer science ,medicine ,3d model ,Virtual reality ,medicine.disease ,Biomedical engineering ,Visualization ,Coil embolization - Abstract
In this study, a system has been developed to draw three-dimensional coordinates of a catheter in real time using Unity for cerebral aneurysm coil embolization, which is one of the endovascular treatments. The system detects the tip of a catheter by binarization and delineation from X-ray images taken from two directions (frontal and lateral views) and calculates the tip coordinates of the catheter in the 3D model of blood vessels generated using VTK from DICOM images. In this system, surgeons can more effectively visualize the catheter tip in 3D by using an head-mounted display, a virtual reality device. In the evaluation experiment, we compared the catheter tip detection with conventional methods and found that it was faster and more accurate than conventional methods. Future tasks include accurate positioning of 2D images and 3D models and drawing catheters other than the tip.
- Published
- 2021
3. FRI0446 Initial predictors for mortality in patients with cancer-associated myositis: a multicenter retrospective cohort in japan
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Chihiro Terai, S. Kobayashi, Takahisa Gono, Yuka Okazaki, Y. Nakajima, Yukie Yamaguchi, Eri Watanabe, Mitsuhiro Takeno, Yuichiro Shirai, Masataka Kuwana, and H. Kadota
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030203 arthritis & rheumatology ,0301 basic medicine ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,business.industry ,Proportional hazards model ,Retrospective cohort study ,Dermatomyositis ,medicine.disease ,Malignancy ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Internal medicine ,Cohort ,medicine ,business ,Myositis - Abstract
Background Concomitant malignancy is one of the prognostic factors in patients with myositis,1 but clinical parameters for mortality still remain unknown in patients with cancer-associated myositis (CAM). Objectives Initial predictors for mortality were examined using a multicenter cohort of CAM patients. Methods This retrospective study enrolled 67 consecutive patients diagnosed as having CAM in 3 referral hospitals between 1995 and 2017. Clinical data at diagnosis of myositis as well as treatment regimens and outcomes of myositis and malignancy were collected by review of medical charts. Myositis-specific autoantibodies (MSAs) were comprehensively detected using RNA immunoprecipitation (IP), enzyme-linked immunosorbent assay, and IP-immunoblotting. We initially conducted a univariate analysis to select variables that were different between survivors and dead cases. In multivariate analysis, the Cox proportional hazard model with backward selection method (p>0.20) was employed to identify factors independently associated with mortality. Explanatory variables were chosen based on the following three models. The Model 1 included age at diagnosis of myositis, gender and candidate variables (p Results The median age at diagnosis of myositis was 63 years, and 62% were female. MSAs were detected in 47 patients: anti-TIF1-γ in 27, anti-ARS in 6, anti-MDA5 in 5, anti-Mi-2 in 3, anti-NXP2 in 3, anti-SAE in 2, and anti-SRP in 1. During the median observation period of 2 years, 19 (28%) of 67 CAM patients were dead due to tumour in 16, ILD in 1, and an unknown cause in 2. The univariate analysis identified significant poor prognostic factors (p Conclusions Male and progression of malignancy at diagnosis of myositis were identified as predictors of survivals in CAM patients. Reference [1] Callen JP. Dermatomyositis. Lancet2000;355:53–7. Disclosure of Interest H. Kadota: None declared, T. Gono: None declared, Y. Yamaguchi: None declared, E. Watanabe: None declared, Y. Okazaki: None declared, Y. Nakajima: None declared, S. Kobayashi: None declared, Y. Shirai: None declared, M. Takeno: None declared, C. Terai: None declared, M. Kuwana Grant/research support from: Astellas, Speakers bureau: Astellas and Japan Blood Products Organisation
- Published
- 2018
4. Comparative Analyses between Thoracotomy and Thoracoscopic Approach in Total Pharyngolaryngoesophagectomy for Esophageal Cancer
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E. Oki, Q. Hu, S. Sasaki, K. Hirose, H. Kadota, Y. Tsuda, T. Jogo, R. Yasumatsu, H. Saeki, Y. Hisamatsu, Y. Nakashima, and K. Ando
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Medicine ,Thoracotomy ,Esophageal cancer ,business ,medicine.disease ,Surgery - Published
- 2019
5. Freeze Concentration of Equal Molarity Solutions with Ultrasonic Irradiation Under Constant Freezing Rate
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H. Kadota, Akira Matsuda, and K. Kawasaki
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Ultrasonic irradiation ,Molar concentration ,Chemistry ,General Chemical Engineering ,Diffusion ,Congelation ,Analytical chemistry ,Ionic bonding ,Thermodynamics ,General Chemistry ,Constant (mathematics) ,Intensity (heat transfer) - Abstract
The performance of freeze concentration at constant freezing rate (40 mm h–1) with/ without ultrasonic irradiation was examined using three one-component solutions containing only one solute (ionic or molecular concentration: 0.03 mol L–1) and a three-component solution containing three solutes (each component concentration: 0.01 molL–1). Without ultrasonic irradiation the solutes are hardly concentrated at this freezing rate. On the other hand, with ultrasonic irradiation, the concentration efficiency increases with increasing intensity of ultrasonic irradiation. The solutes of smaller molecular weight are concentrated more effectively than solutes of larger molecular weight, regardless of the intensity of ultrasonic irradiation. This corresponds well to the magnitude of the diffusion coefficient of each solute. The difference between the concentration efficiencies of each solute in the three-component solution is smaller than that between the concentration efficiencies in the one-component solution, but the order of the values of the efficiencies is the same.
- Published
- 2006
6. Recent Developments in Fabrication of New Conceptual Gold Cone and Machining of Polystyrene Shell for Fast Ignition Target
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M. Nakai, M. Nagata, H. Kadota, Keiji Nagai, Takayoshi Norimatsu, Hiroshi Azechi, Takeshi Fujimura, H. Hosokawa, and H. Homma
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Nuclear and High Energy Physics ,Fabrication ,Materials science ,020209 energy ,Shell (structure) ,Phase (waves) ,Nanotechnology ,02 engineering and technology ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,chemistry.chemical_compound ,Optics ,Machining ,law ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Civil and Structural Engineering ,business.industry ,Mechanical Engineering ,Laser ,Ignition system ,Nuclear Energy and Engineering ,chemistry ,Sapphire ,Polystyrene ,business - Abstract
Recent developments of several key issues for fabrication techniques of cone and shell target for the first phase of the Fast Ignition Realization Experiment (FIREX-I) project at the Institute of Laser Engineering, Osaka University, are described in this paper. The most important modification of the target design is a double cone, and a new fabrication technique has been developed. Although the error of assembling the cones is still several microns, the first prototype of a double-cone target with a vacuum gap of 20 μm was successfully provided for the preliminary experiment. Additionally, Ti:sapphire laser machining was used to bore a hole in the polystyrene shell.
- Published
- 2011
7. ChemInform Abstract: Pyrazines. Part 23. Homolytic Acylation of 2-Amino-3-cyanopyrazine and the Related Compounds with α-Keto Acids: A Synthesis of 5-Acyl-3- aminopyrazinecarboxylic Acid Derivatives
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H. Kadota and Nobuhiro Sato
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Acylation ,Chemistry ,Organic chemistry ,General Medicine ,Cyanopyrazine ,Homolysis - Published
- 2010
8. Processing element design for a parallel computer
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Ichiro Okabayashi, J. Nishikawa, Katsuyuki Kaneko, Y. Kakakura, M. Nakajima, and H. Kadota
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Very-large-scale integration ,Reduced instruction set computing ,CMOS ,Parallel processing (DSP implementation) ,Hardware and Architecture ,Computer science ,Processing element ,Limit (music) ,Parallel computing ,Electrical and Electronic Engineering ,FLOPS ,Software - Abstract
A study has been made of how cost-effectiveness due to the improvement of VLSI technology can apply to a scientific computer system without performance loss. The result is a parallel computer, ADENA (Alternating Direction Edition Nexus Array), with a core consisting of four kinds of VLSI chips, two for processor elements (PES) and two for the interprocessor network (plus some memory chips). An overview of ADENA and an analysis of its performance are given. The design considerations for the PEs incorporated in ADENA are discussed. The factors that limit performance in a parallel processing environment are analyzed, and the measures employed to improve these factors at the LSI design level are described. The 42.6 sq cm CMOS PEs reach a peak performance of 20 MFLOPS and a 256-PE ADENA 1.5 GFLOPS has been achieved and 300 to 400 MFLOPS for PDE applications. >
- Published
- 1990
9. A CMOS 32b microprocessor with on-chip cache and transmission lookahead buffer
- Author
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T. Okamoto, E. Ichinohe, H. Kadota, Y. Takagi, J. Miyake, I. Okabayashi, K. Kagawa, and T. Maeda
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Adder ,Random access memory ,Computer science ,business.industry ,Buffer (optical fiber) ,law.invention ,Microprocessor ,Transmission (telecommunications) ,CMOS ,law ,Electronic engineering ,Cache ,business ,Cmos process ,Computer hardware - Published
- 2005
10. A new reconfigurable architecture with smart data-transfer subsystems for the intelligent image processing
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A. Wakatani, Y. Hori, and H. Kadota
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Adder ,Computer architecture ,Computer science ,Transfer (computing) ,Digital image processing ,Multistage interconnection networks ,Wavelet transform ,Image processing ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,Image (mathematics) ,Block (data storage) - Abstract
New reconfigurable accelerator architecture suitable for the intelligent image processing is proposed. Not only reconfigurable processing-unit blocks, but also smart data-transfer subsystems which consist of multistage interconnection networks and special buffers are implemented. The subsystem can supply any combinations of 8 /spl times/ 8 local image data simultaneously to the arbitrary processing units. The processing-unit block consists of arrays of arithmetic units which can be reconfigured as parallel adders/subtracters or multipliers with various precision. The peak performance of this accelerator is 204BOPS which is sufficient for the wavelet transforms in the real-time intelligent image-processing applications.
- Published
- 2005
11. A new inter-core built-in-self-test circuit for tri-state buffers in the system-on-a-chip
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M. Ohta, T. Taniguchi, H. Kadota, and T. Kishi
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business.industry ,Computer science ,Mixed-signal integrated circuit ,Hardware_PERFORMANCEANDRELIABILITY ,Automatic test pattern generation ,Circuit extraction ,Application-specific integrated circuit ,Built-in self-test ,Embedded system ,Hardware_INTEGRATEDCIRCUITS ,System on a chip ,State (computer science) ,business ,Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION ,Hardware_LOGICDESIGN ,Electronic circuit - Abstract
A new inter-core BIST circuit for tri-state buffers, T-BIST, mainly consists of simple circuits distributed in the relevant blocks. It can give an excellent test-coverage with a little additional hardware. Its configuration is not specified by each SoC structure, so it is suitable for a general/reusable testable IP.
- Published
- 2002
12. Measurement of intracellular Na+ concentration by a Na+-sensitive fluorescent dye, sodium-binding benzofuran isophthalate, in porcine adrenal chromaffin cells--usage of palytoxin as a Na+ ionophore
- Author
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Shigeo Ito, Yoshikazu Nakazato, H Kadota, Toshio Ohta, and Naoki Kitamura
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Nicotine ,Patch-Clamp Techniques ,Stereochemistry ,Swine ,Sodium ,Chromaffin Cells ,Ionophore ,Drug Evaluation, Preclinical ,chemistry.chemical_element ,Membrane Potentials ,chemistry.chemical_compound ,Cnidarian Venoms ,Palytoxin ,Ethers, Cyclic ,medicine ,Animals ,Patch clamp ,Cells, Cultured ,Benzofurans ,Fluorescent Dyes ,Acrylamides ,Ionophores ,General Neuroscience ,Gramicidin ,medicine.anatomical_structure ,chemistry ,Chromaffin cell ,Calibration ,Biophysics ,Adrenal medulla ,Dialysis ,Intracellular - Abstract
Palytoxin was found to equilibrate sodium ions (Na+) across the cell membrane much faster than dose gramicidin, which has been frequently used to calibrate the intracellular Na+ concentration ([Na+]in), in cells treated with a Na+-sensitive fluorescent dye, sodium-binding benzofuran isophthalate (SBFI). Palytoxin was capable of equilibrating Na+ in cells treated with SBFI-acetoxymethyl ester (SBFI-AM) and in voltage-clamped cells loaded with SBFI through a patch pipette. Nicotine caused a dose-dependent increase in ([Na+]in) in porcine adrenal chromaffin cells treated with SBFI-AM and caused a simultaneous increase in [Na+]in and inward current in the voltage-clamped cells loaded with SBFI. Palytoxin has an advantage of calibrating ([Na+]in) in a shorter time than dose gramicidin because of its powerful ionophoretic activity.
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- 1997
13. P29-27 TMS-induced artifacts on EEG can be reduced by rearrangement of the electrode's lead wire before recording
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H. Sekiguchi, S. Takeuchi, H. Kadota, Y. Kohno, and Y. Nakajima
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Neurology ,Physiology (medical) ,Neurology (clinical) ,Sensory Systems - Published
- 2010
14. A proposed structure of a 4 Mbit content-addressable and sorting memory
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H. Kadota, I. Okabayashi, and H. Kotani
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Hardware_MEMORYSTRUCTURES ,business.industry ,Megabit ,Relational database ,Computer science ,Volume (computing) ,Sorting ,Content-addressable storage ,Content-addressable memory ,Chip ,business ,Computer hardware ,Electronic circuit - Abstract
A new structure for a high-density 4-Mb CAM (content addressable memory) with sorting function (sort-CAM) is proposed. Retrieval or sorting operations are done in word-parallel/bit-serial manner at the device. This is different from previous CAMs where operations are done in word-parallel/bit-parallel or flash manner. The device organization, circuits for retrieval or sorting, and chip operations are explained. Estimated performance of the device and chip size are also discussed. The device has 64 K-wordt64-b organization and a 3.1-MB/s sorting speed. In practical applications, such as RDB (relational database) systems, this speed is enough, but a number of chips should be connected if larger data volume is needed
- Published
- 1990
15. A 32-bit CMOS microprocessor with on-chip cache and TLB
- Author
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T. Okamoto, H. Kadota, T. Maeda, J. Miyake, K. Kagawa, Masaitsu Nakajima, and I. Okabayashi
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Very-large-scale integration ,Hardware_MEMORYSTRUCTURES ,CPU cache ,business.industry ,Computer science ,Translation lookaside buffer ,law.invention ,Microarchitecture ,Instructions per second ,Microprocessor ,law ,Barrel shifter ,Embedded system ,Cache ,Electrical and Electronic Engineering ,business ,Instruction cycle - Abstract
A 32-b general-purpose microprocessor has been developed using 1-/spl mu/m CMOS technology. The chip, containing 372 K transistors, operates at a 80-ns machine cycle time with a 5-V power supply. For virtual and hierarchical memory system support, a 64-entry full-associative translation lookaside buffer (TLB) and a 2-kbyte instruction cache are implemented on the chip. The internal access times for the TLB and cache are 22 and 18 ns, respectively. The microarchitecture has been designed to reduce the pipeline to three stages, simplifying the control path and obtaining high-speed performance. The data path of this chip is also enhanced with hardware, such as a barrel shifter and multiplier/divider. The chip performance has been measured to be 5.1 million instructions per second (MIPS) and 50-ns-access main memory.
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- 1987
16. A new register file structure for the high-speed microprocessor
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S. Ozawa, E. Ichinohe, K. Kawakami, and H. Kadota
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Memory buffer register ,Processor register ,business.industry ,Computer science ,Register file ,FLAGS register ,Register renaming ,Parallel computing ,Stack register ,law.invention ,16-bit ,Memory address register ,Microprocessor ,Control register ,law ,Status register ,Index register ,Electrical and Electronic Engineering ,Memory data register ,business ,Instruction cycle ,Computer hardware - Abstract
The pipeline operations of the register file in a microprocessor are analyzed in detail. Conventional register files, two-port static RAMs, have two problems in successive write-to-read operations. (1) A read-time error takes place when the transition of the W/R mode and the transition of register address occur simultaneously. (2) A write-time error takes place when the supply voltage is slow. A new register file structure is proposed, which has three address word lines and four data bit lines for each memory cell. This structure enables the independent write and read operations to each other, and can solve the two problems. By using this register file structure, a new 16 bit microprocessor with 250 ns machine cycle time is successfully developed. Several other features of this processor are also explained and discussed.
- Published
- 1982
17. Microbiological studies on salfed fish stored at low temperature. I. Chemical and microbial changes of salted fish during storage
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H Kadota, T Fujii, and Y Ishida
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,Total volatile ,Base (chemistry) ,Chemistry ,Food spoilage ,Trimethylamine ,%22">Fish ,Food science ,Aquatic Science ,Free amino ,Salted fish - Abstract
Fish muscle homogenates with NaCl (5 or 15%) and those without NaCl were stored at 0° and 10°C. During the storage, the changes in viable counts, trimethylamine (TMA) and total volatile base (TVB) concentrations, 2-thiobarbituric acid (TBA) values, concen-trations of free amino acids, pH, Eh and water contents were observed. All the changes observed at 0°C were much smaller and slower than at 10°C. The most significant differences between the homogenates with NaCl and those without NaCl were found in respect to the TMA concentration;in the presence of more than 5% NaCl the TMA concentration did not exceed the threshold value of spoilage, whereas in the absence of NaCl it exceeded the threshold value within a short time.
- Published
- 1976
18. An 8-kbit content-addressable and reentrant memory
- Author
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H. Kadota, K. Kagawa, Y. Nishimichi, H. Kudoh, and J. Miyake
- Subjects
Random access memory ,CMOS ,business.industry ,Computer science ,Dataflow ,Computer data storage ,Electrical and Electronic Engineering ,Content-addressable memory ,business ,Encoder ,Computer hardware ,Garbage collection - Abstract
A 256-word/spl times/32-bit associated memory, referred to as the Content Addressable and Reentrant Memory (CARM), with a 100-ns cycle time is described. The high bit density of the device is realized by a small-size associative memory cell (30/spl times/36 /spl mu/m/SUP 2/) with 2-/spl mu/m CMOS technology, while a double-layer metallization technique, new circuits for the control-signal propagation, and a hierarchical structure for the address encoder of the chip allow fast access. This device has reentrant mode operation, where the on-chip garbage collection or data storage is accomplished conditionally. One of the practical applications of this device, a high-speed matching unit for dataflow computers, is also discussed.
- Published
- 1985
19. The accumulation of colonies of Uroglena americana in Lake Biwa
- Author
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H. Kadota, T. Matsumoto, Y. Yoshida, T. Uda, and K. Numata
- Subjects
Uroglena americana ,Botany ,Biology - Published
- 1981
20. Functor: A higher-level co-operating program model
- Author
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M. Ohba, H. Kadota, Y. Tanitsu, and N. Takimoto
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Functor ,business.industry ,Computer programming ,Petri net ,Data structure ,Data flow diagram ,Algebra ,Psychiatry and Mental health ,Control flow ,Neuropsychology and Physiological Psychology ,Kernel (statistics) ,Automata theory ,business ,Algorithm ,Mathematics - Abstract
Programs consist of algorithms and data structures. Extending this well-known basic concept, algorithms can be regarded as consisting of algorithms for control-flow and algorithms for data-flow. On the basis of the separation of control and data flow, the functor model is proposed to describe the interaction among co-operating concurrent modules within the given programming system, and the functorfunctor kernel is also proposed to specify the internal control flow of each functor model as a pushdown-automaton.
- Published
- 1981
21. Calibration of the Pressure Sensor of Ridged Sheet Type and its Application to Some Cold Forging Processes of Aluminium
- Author
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T. Yamanoi, H. Kudo, H. Kadota, and S. Matsubara
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Materials science ,Mechanical Engineering ,Metallurgy ,Rotational symmetry ,chemistry.chemical_element ,macromolecular substances ,Field analysis ,Pressure sensor ,Industrial and Manufacturing Engineering ,Forging ,Brass ,chemistry ,Aluminium ,visual_art ,Calibration ,visual_art.visual_art_medium ,Extrusion - Abstract
Summary The present sensor is, as reported previously, a brass sheet having a ridged surface which is inserted into the tool-workpiece interfaces to measure the width of flattened plateau of the ridges as the index of the pressure exerted during forging. In order to examine the reliability of the response of the sensor to non-uniform pressure distribution, pressure distributions over some tool surfaces were determined in several plane-strain extrusion processes of fully work-hardened aluminium specimens and the results were compared with the theoretical results obtained from the slip-line field analysis. The discrepancies were found to be within 5 to 10 per cent. The sensers were then applied to determine pressure distributions in some plane-strain and axisymmetric cold forging processes of work-hardened and annealed specimens. Generally the pressure distribution of hardened aluminium over a tool surface showed a more marked non-uniformity than did that of the annealed. A simple law that correlates the container pressure with the extrusion pressure was obtained. Thus, for a given extrusion geometry, the non-deforming portion of annealed specimen exerted a higher pressure over the container surface than did that of the hardened, while the latter required a higher extrusion pressure.
- Published
- 1983
22. Radiosensitivity to gamma rays of spores of a DNA polymerase deficient mutant of Bacillus subtilis
- Author
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H. Terano and H. Kadota
- Subjects
DNA, Bacterial ,Spores, Bacterial ,Health, Toxicology and Mutagenesis ,Mutant ,Gamma ray ,Deficient mutant ,Bacillus subtilis ,Biology ,biology.organism_classification ,Molecular biology ,Centrifugation, Zonal ,Spore ,Microbiology ,DNA Nucleotidyltransferases ,Mutation ,Genetics ,biology.protein ,Radiation Genetics ,A-DNA ,Radiosensitivity ,Molecular Biology ,Polymerase - Published
- 1974
23. [Measurement of radiation for technicians]
- Author
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H, KADOTA
- Subjects
Radiation ,Research ,Humans ,Radiometry - Published
- 1962
24. [Fibrinolysis and hypofibrinogenemia associated with cancer of the prostate: report of a case]
- Author
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I, HAYASHI, H, YANO, T, SAKURAI, F, MURAKAMI, H, KADOTA, and K, KUSAKARI
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Male ,Fibrinolysis ,Neoplasms ,Humans ,Prostatic Neoplasms ,Hemorrhagic Disorders ,Medical Records - Published
- 1962
25. [Radiological image in acute gastritis]
- Author
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H, Irie, S, Yoshimoto, K, Fujii, S, Inoue, and H, Kadota
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Adult ,Male ,Radiography ,Gastritis ,Humans ,Female ,Middle Aged - Published
- 1966
26. Production of volatile sulfur compounds by microorganisms
- Author
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H Kadota and Y Ishida
- Subjects
inorganic chemicals ,Antifungal Agents ,Microorganism ,Hydrogen sulfide ,chemistry.chemical_element ,Food Contamination ,Sulfides ,Microbiology ,Sulfonium Compounds ,chemistry.chemical_compound ,Methionine ,Food microbiology ,Animals ,Cysteine ,Disulfides ,Hydrogen Sulfide ,Sulfhydryl Compounds ,Sulfate ,biology ,Bacteria ,Sulfates ,Fungi ,Eukaryota ,biology.organism_classification ,Sulfur ,Flavoring Agents ,chemistry ,Environmental chemistry ,Food Microbiology ,Dairy Products - Abstract
OCCURRENCE OF MICROBIAL VOLATILE SULFUR CoMPOUNDS.. . . • . . . . . • . . . . . . . . • 127 MECHANISMS INVOLVED IN PRODUCTION OF VOLATILE SULFUR COMPOUNDS BY J' MICROORGANISMS . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . �Evolution as a result of dissimilation of methionine . . . . . . . . . . . . . . .. . . . . . . . . . . ;--Formation from S-methylcysteine . � Formation from other S-alkylcysteines and S-allylcysteine, and their sulfoxides . . ,. Evolution from sulfonium compounds . �. '':_ Evolution from sulfate . ApPLIED AsPECTS OF VOLATILE SULFUR CoMPOUNDS FROM MICROORGANISMS . • . . . Inhibitory effect of volatile sulfur compounds on germination of pathogenic fungi. Volatile sulfur compounds in dairy products . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . Evolution of volatile sulfur compounds during storage of foods .
- Published
- 1972
27. [Clinical surgery and fibrinolysis]
- Author
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F, Murakami and H, Kadota
- Subjects
Adult ,Male ,Adolescent ,Fibrinolysis ,Surgical Procedures, Operative ,Humans ,Female ,Hemorrhage ,Thrombosis ,Middle Aged ,Antifibrinolytic Agents ,Aged - Published
- 1966
28. Appearance of spore coat protein in the cell extracts of Bacillus subtilis asporogenic mutants
- Author
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P Schaeffer, A Uchida, and H Kadota
- Subjects
Spores, Bacterial ,Mutation ,fungi ,Mutant ,Cell ,Spore coat ,Bacillus subtilis ,Biology ,medicine.disease_cause ,biology.organism_classification ,Microbiology ,Spore ,Bacterial protein ,Cell wall ,medicine.anatomical_structure ,Bacterial Proteins ,Cell Wall ,medicine ,Molecular Biology ,Research Article - Abstract
By use of the antigen-antibody techniques we have studied whether asporogenic mutants of Bacillus subtilis can synthesize the spore coat protein. Antibody specific to spore coat protein was prepared and used to demonstrate that the spore coat protein was synthesized at the early stage of sporulation. We report here that asporogenic mutants synthesize the spore coat protein.
- Published
- 1976
29. Combined local flap placement and negative-pressure wound therapy for the management of critical peritracheostomal pharyngocutaneous fistula.
- Author
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Kadota H, Oryoji C, Fukushima S, Shimamoto R, Kamizono K, and Yoshida S
- Abstract
Objective: Peritracheostomal pharyngocutaneous fistula (PCF), a direct connection between the PCF and tracheal stoma due to a skin defect, is among the most problematic complications after total laryngectomy or pharyngolaryngectomy. Peritracheostomal PCFs can cause lethal complications, including severe pneumonia or carotid blowout, secondary to salivary leakage directly into the tracheal stoma, and their management is challenging without early invasive surgical closure. We aimed to evaluate the utility of our novel and minimally invasive combined local skin flap placement and negative-pressure wound therapy (NPWT) method for the management and conservative closure of peritracheostomal PCFs., Methods: We retrospectively enrolled patients who developed a peritracheostomal PCF from July 2015 to September 2021 at our institution and affiliated hospitals. Postoperative PCFs were all initially managed with appropriate wound bed preparation. Subsequently, a small local flap of healthy, lower neck skin was elevated and transferred anterior to the PCF to replace the peritracheostomal skin defect. The flap served to provide a sufficient surface for film dressing attachment and facilitated airtight sealing during NPWT. We initiated NPWT after confirming the local skin flap was firmly sutured to the tracheal mucosa. A flexible hydrocolloid dressing was applied to the peritracheostomal skin flap, and a film dressing was placed on the flexible hydrocolloid dressing and surrounding cervical skin. We inserted the NPWT foam shallowly into the fistula tract and applied negative pressure (73.5-125 mmHg). NPWT was continued until the PCF was closed or became so small that salivary leakage was minimal and could be managed by conventional compression dressings., Results: We enrolled six patients [male, n = 6; mean age, 66.5 years (range, 57-80 years)]. NPWT was applied for an average of 18.2 days (range, 2-28 days). During NPWT, air leakage occurred once (2 cases), only a few times (2 cases), or not at all (2 cases). In all patients, complete fistula closure was achieved in an average of 28.2 days (range, 15-55 days) after the start of NPWT, and no patient required further surgical intervention. There were no lethal complications (e.g., severe pneumonia) during treatment., Conclusion: Our method of combined local flap placement and NPWT enabled effective management of salivary aspiration and accelerated wound healing, which allowed conservative fistula closure in all patients. We believe combined local flap placement and NPWT should be considered a first-line treatment for intractable peritracheostomal PCF., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
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30. Rapid Forehead Ossification due to a Subperiosteal Hematoma in a Patient With Neurofibromatosis Type 1.
- Author
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Anan K, Kadota H, and Oryoji C
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- Humans, Male, Adult, Biopsy, Fine-Needle, Diagnosis, Differential, Neurofibromatosis 1 complications, Hematoma etiology, Hematoma diagnostic imaging, Forehead, Periosteum pathology, Periosteum diagnostic imaging, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Ossification, Heterotopic diagnostic imaging, Ossification, Heterotopic etiology, Ossification, Heterotopic pathology
- Abstract
Rapid ossification due to a subperiosteal hematoma in extremities has occasionally been documented in patients with neurofibromatosis type 1, but it has not been reported in the maxillofacial region. The authors present the first case of a subperiosteal hematoma in the forehead. A 36-year-old man presented with a rapidly swelling firm, fixed, 8×10 cm forehead mass. It became evident shortly after a fine-needle aspiration biopsy. Computed tomography imaging 2 months after the biopsy showed a hematoma that was encapsulated by a surrounding layer of ossification. Magnetic resonance imaging displayed a fluid-fluid level under the ossified area. These characteristic images led us to diagnose this rare lesion as a subperiosteal hematoma with ossification. Rapid ossification is a characteristic imaging finding of subperiosteal hematoma, which makes definitive diagnosis easy. It becomes imperative to underscore the potential risks of fine-needle aspiration in proximity to the periosteum in patients with neurofibromatosis type 1., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
- Full Text
- View/download PDF
31. Temporoparietal Fascial Flap Combined With Vascularized Outer Table Calvarial Bone Graft and Entire Temporalis Muscle: A Stable Pedicled Flap for Orbital Floor Reconstruction After Total Maxillectomy.
- Author
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Imai Y, Kadota H, and Kogo R
- Abstract
Orbital reconstruction after total maxillectomy is essential to maintain ocular function and facial contour. Free flap transfer with simultaneous orbital bone reconstruction is a straightforward approach; however, it is challenging in medically unstable patients with multimorbidity. The authors developed an easily harvested temporoparietal fascial flap combined with vascularized outer table calvarial bone and entire temporalis muscle. The authors applied this technique in an 81-year-old patient with multiple comorbidities who required orbital floor reconstruction following total maxillectomy. Intraoperative indocyanine green fluorescence imaging confirmed excellent perfusion of the temporoparietal fascia, entire temporalis muscle, and calvarial bone. Although the patient developed postoperative local wound infection, the vascularized bone graft resisted infection and preserved the orbital structure without bone exposure. Our technique is minimally invasive and results in a well-vascularized flap for orbital reconstruction after total maxillectomy involving the orbital bone, and particularly beneficial in patients with multimorbidity or at high risk of local infection., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
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32. Safe and reliable use of supraclavicular flaps for head and neck reconstruction.
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Kadota H and Imai Y
- Abstract
The supraclavicular flap is a regional flap in the supraclavicular area nourished by the transverse cervical or supraclavicular arteries. This flap gained popularity in the 2000s as it requires less surgical time than free flap reconstruction and has minimal donor-site morbidity. However, a high rate of postoperative complications has been reported. Moreover, there is ongoing debate regarding the indications and limitations of this flap. In this study, we confined the flap design to the supraclavicular fossa, considering flap vascularity and in an effort to minimize donor site morbidity. Between 2014 and 2023, we performed supraclavicular flap reconstruction in 3 cases of cervical skin defects and 1 case of a pharyngeal mucosal defect. The average defect and flap sizes were 7×3.9 cm and 11.5×4.4 cm, respectively. The lower border of the flap remained above the clavicle, and the lateral border did not exceed the acromioclavicular joint. When the flaps were transferred using the transposition method, the angle of transposition was limited to <90 degrees. When the VY advancement or turnover method was selected, we paid attention to the tension-free flap inset. We successfully reconstructed the defects without flap-related complications, and donor site scars were inconspicuous in all patients. In conclusion, we believe that confining the flap design to the supraclavicular fossa, limiting the indications of this flap to the reconstruction of medium-sized defects, and using tension-free flap insets are important for the successful application of this flap., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 by Mutaz B. Habal, MD.)
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- 2024
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33. Multiple Lymphaticovenular Anastomoses for Chyluria in Klippel-Trenaunay Syndrome.
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Miyashita K, Kadota H, Hanada M, Inatomi Y, Oryoji C, Morishita A, Yoshida S, Oda Y, and Kinoshita I
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- Humans, Female, Child, Aged, Hematuria complications, Lower Extremity blood supply, Serum Albumin, Klippel-Trenaunay-Weber Syndrome complications, Klippel-Trenaunay-Weber Syndrome surgery, Klippel-Trenaunay-Weber Syndrome diagnosis, Lymphedema surgery, Lymphedema complications, Fistula complications
- Abstract
Abstract: Klippel-Trenaunay syndrome (KTS) is characterized by port-wine stains, mixed vascular malformations, and soft tissue and bone hypertrophy. Klippel-Trenaunay syndrome is occasionally complicated by chyluria, for which there is no effective treatment currently. We report a case of KTS complicated by intractable chyluria and hematuria due to a lymphatic-ureteral fistula. The patient was successfully treated with multiple lymphaticovenular anastomoses (LVAs).A 66-year-old woman with an enlarged left lower extremity since childhood was diagnosed with KTS. At 60 years of age, she developed chyluria (urine albumin, 2224 μg/mL) and hematuria. Lymphoscintigraphy showed a lymphatic-ureteral fistula near the ureterovesical junction. Conservative treatment was ineffective. She also developed left lower extremity lymphedema, which gradually worsened. Leg cellulitis and purulent pericarditis developed because of hypoalbuminemia (minimum serum albumin level, 1.3 g/dL).We performed 14 LVAs in 2 surgeries to reduce lymphatic fluid flow through the lymphatic-ureteral fistula. The chyluria and hematuria resolved soon after the second operation, and the urine albumin level decreased (3 μg/mL). After 28 months, she had no chyluria or hematuria recurrence and her serum albumin level improved (3.9 g/dL). Multiple LVAs can definitively treat chyluria caused by a lymphatic-ureteral fistula in patients with KTS., Competing Interests: Conflicts of interest and sources of funding: The authors received no grants for the research, authorship, and/or publication of this article., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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34. Immediate sciatic nerve reconstruction using an ipsilateral common peroneal nerve graft at the time of sarcoma resection.
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Hanada M, Kadota H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, and Nakashima Y
- Subjects
- Male, Humans, Female, Middle Aged, Quality of Life, Sciatic Nerve surgery, Thigh, Treatment Outcome, Peroneal Nerve surgery, Sarcoma surgery
- Abstract
Background: Concomitant resection of the sciatic nerve along with a malignant tumor is no longer a contraindication for limb-sparing surgery, as most of these patients remain ambulatory. However, sciatic nerve reconstruction after sarcoma resection is not commonly performed. Restoration of nerve function can improve patient quality of life. We describe our experience with four patients who underwent sciatic nerve reconstruction using an ipsilateral common peroneal nerve graft at the time of sarcoma resection., Methods: Because of the low chance of peroneal nerve recovery, the ipsilateral peroneal trunk was used as a graft to reconstruct the tibial trunk of the sciatic nerve. Two patients were men and two were women. Mean age was 45.3 years (range, 15-62). Mean sciatic nerve defect length was 9.4 cm (range, 8.5-12.0). Proximal thigh defects (three patients) were reconstructed with a double cable; the one patient with a distal thigh defect underwent single cable reconstruction. Mean operation time was 492 min (range, 428-682)., Results: Mean length of the harvested peroneal trunks was 21 cm (range, 11-26). Mean graft length was 11.9 cm (range, 11-13). Postoperative course was uneventful in all four patients. One patient died of sarcoma lung metastasis and could not be evaluated. Three patients were followed for more than 2 years. Two patients achieved British Medical Research Council grade 4 plantar flexion; the remaining patient achieved grade 5 plantar flexion and grade 4 toe flexion. Semmes-Weinstein monofilament sensory testing showed loss of protective sensation on the plantar surface in all three. Musculoskeletal Tumor Society scores at last follow-up were 60.0%, 70.0%, and 43.3%, respectively., Conclusions: Immediate sciatic nerve reconstruction using an ipsilateral common peroneal nerve graft avoids reconstruction delay and scar tissue formation, which is advantageous for nerve recovery. This technique may be considered when sciatic nerve resection is anticipated during sarcoma resection., (© 2023 Wiley Periodicals LLC.)
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- 2024
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35. Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient.
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Miyamoto R, Takigawa H, Kotachi T, Kadota H, Yuge R, Hayashi R, Urabe Y, Ishikawa A, Sentani K, and Oka S
- Subjects
- Male, Humans, Aged, Positron Emission Tomography Computed Tomography adverse effects, Stomach Neoplasms diagnosis, Lymphoma, B-Cell, Marginal Zone diagnostic imaging, Lymphoma, B-Cell, Marginal Zone surgery, Helicobacter Infections complications, Helicobacter pylori genetics, Adenocarcinoma pathology
- Abstract
We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous-inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind., (© 2023. Japanese Society of Gastroenterology.)
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- 2023
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36. The Anti-Tumor Effect of the Newly Developed LAT1 Inhibitor JPH203 in Colorectal Carcinoma, According to a Comprehensive Analysis.
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Otani R, Takigawa H, Yuge R, Shimizu D, Ariyoshi M, Miyamoto R, Kadota H, Hiyama Y, Hayashi R, Urabe Y, Ishikawa A, Oue N, Kitadai Y, Oka S, and Tanaka S
- Abstract
A novel large neutral amino acid transporter 1 (LAT1)-specific inhibitor, JPH203, is expected to cause cancer-specific starvation and possess anti-tumor effects; however, its anti-tumor mechanism for colorectal cancer (CRC) remains unclear. We analyzed LAT family gene expressions in public databases using UCSC Xena and evaluated LAT1 protein expression using immunohistochemistry in 154 cases of surgically resected CRC. We also evaluated mRNA expression using polymerase chain reaction in 10 CRC cell lines. Furthermore, JPH203 treatment experiments were conducted in vitro and in vivo using an allogeneic immune-responsive mouse model with abundant stroma created via the orthotopic transplantation of the mouse-derived CRC cell line CT26 and mesenchymal stem cells. The treatment experiments were followed by comprehensive gene expression analyses with RNA sequencing. Database analyses and immunohistochemistry research on clinical specimens revealed that LAT1 expression was cancer-dominant, and its increase was accompanied by tumor progression. In vitro, JPH203 was effective in an LAT1 expression-dependent manner. In vivo, JPH203 treatment considerably reduced tumor size and metastasis, and RNA sequencing-based pathway analysis showed that not only tumor growth and amino acid metabolism pathways, but also stromal activation-related pathways were suppressed. The results of the RNA sequencing were validated in the clinical specimens, as well as both in vitro and in vivo. LAT1 expression in CRC plays an important role in tumor progression. JPH203 may inhibit the progression of CRC and tumor stromal activity.
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- 2023
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37. Comprehensive Analysis of Gene Expression Profiling to Explore Predictive Markers for Eradication Therapy Efficacy against Helicobacter pylori -Negative Gastric MALT Lymphoma.
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Takigawa H, Yuge R, Miyamoto R, Otani R, Kadota H, Hiyama Y, Hayashi R, Urabe Y, Sentani K, Oue N, Kitadai Y, Oka S, and Tanaka S
- Abstract
Although radiotherapy is the standard treatment for Helicobacter pylori (Hp)-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma, eradication therapy using antibiotics and an acid secretion suppressor can sometimes induce complete remission. We explored predictive markers for the response to eradication therapy for gastric MALT lymphoma that were negative for both API2-MALT1 and Hp infection using comprehensive RNA sequence analysis. Among 164 gastric MALT lymphoma patients who underwent eradication therapy as primary treatment, 36 were negative for both the API2-MALT1 fusion gene and Hp infection. Based on eradication therapy efficacy, two groups were established: complete response (CR) and no change (NC). The Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that cancer-related genes and infection-related genes were highly expressed in the NC and CR groups, respectively. Based on this finding and transcription factor, gene ontology enrichment, and protein-protein interaction analyses, we selected 16 candidate genes for predicting eradication therapy efficacy. Real-time PCR validation in 36 Hp-negative patients showed significantly higher expression of olfactomedin-4 ( OLFM4 ) and the Nanog homeobox ( NANOG ) in the CR and NC groups, respectively. OLFM4 and NANOG could be positive and negative predictive markers, respectively, for eradication therapy efficacy against gastric MALT lymphoma that is negative for both API2-MALT1 and Hp infection.
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- 2023
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38. Tertiary lymphoid structures in the primary tumor site of patients with cancer-associated myositis: A case-control study.
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Kadota H, Gono T, Kunugi S, Ota Y, Takeno M, Seike M, Shimizu A, and Kuwana M
- Abstract
Objective: To investigate histologic features of immunological components in the primary tumor site of patients with cancer-associated myositis (CAM) by focusing on tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs), which play major roles in antitumor immunity., Methods: Cancer-associated myositis patients were selected from the single-center idiopathic inflammatory myopathy cohort based on the availability of primary tumor specimens obtained before the introduction of immunomodulatory agents. Control cancer subjects without CAM were selected from the cancer tissue repository at a ratio of 1:2 matched for demographics and cancer characteristics of CAM cases. A series of immunohistochemical analyses was conducted using sequential tumor sections. TLS was defined as an ectopic lymphoid-like structure composed of DC-LAMP
+ mature dendritic cells, CD23+ follicular dendritic cells (FDCs) and PNAd+ high endothelial venules. TLS distribution was classified into the tumor center, invasive margin, and peritumoral area., Results: Six CAM patients and 12 matched non-CAM controls were eligible for the study. There was no apparent difference in the density or distribution of TILs between the groups. TLSs were found in 3 CAM patients (50%) and 4 non-CAM controls (33%). TLSs were exclusively located at the tumor center or invasive margin in CAM cases but were mainly found in the peritumoral area in non-CAM controls. FDCs and class-switched B cells colocalized with follicular helper T cells were abundantly found in the germinal center-like area of TLSs from CAM patients compared with those from non-CAM controls., Conclusion: The adaptive immune response within TLSs in the primary tumor site might contribute to the pathogenic process of CAM., Competing Interests: TG received speaking fees from Astellas, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, MBL, Nippon Shinyaku, and Ono Pharmaceuticals. MT received consulting and speaking fees from Amgen, research grants and speaking fee from AbbVie, Asahi Kasei, Chugai, Eisai, and Tanabe-Mitsubishi, and speaking fee from Astellas, Ayumi, Boehringer Ingelheim, Eli Lilly, Jansen Pharma, Nippon Shinyaku, Novartis, Ono Pharmaceuticals, Takeda, Taisyo, UBC Japan, and Viatris. MS received the research grants from Chugai, Taiho, Lilly, Boehringer Ingelheim, Nippon Kayaku, and speaking fees from AstraZeneca, Chugai, Taiho, MSD, Lilly, Takeda, Bristol Myers Squibb, Pfizer, Nippon Kayaku, Ono Pharmaceuticals, and Kyowa Kirin Pharmaceuticals. MK holds the patent for the anti-MDA5 antibody measurement kit and received consulting fees, speaking fees, and research grants from AbbVie, Asahi Kasei, Astellas, Boehringer Ingelheim, Chugai, Eisai, Corbus, Kissei, MBL, Mitsubishi Tanabe, Mochida, Nippon Shinyaku, and Ono Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Kadota, Gono, Kunugi, Ota, Takeno, Seike, Shimizu and Kuwana.)- Published
- 2023
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39. Anti-Programmed Cell Death-1 Antibody and Dasatinib Combination Therapy Exhibits Efficacy in Metastatic Colorectal Cancer Mouse Models.
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Kadota H, Yuge R, Shimizu D, Miyamoto R, Otani R, Hiyama Y, Takigawa H, Hayashi R, Urabe Y, Kitadai Y, Oka S, and Tanaka S
- Abstract
In this study, we investigated the in vivo metastasis suppression effects of the platelet-derived growth factor receptor inhibitor dasatinib, which targets cancer-associated fibroblasts (CAFs), in combination with an anti-programmed cell death-1 (PD-1) antibody. We classified clinical CRC cases as inflamed, excluded, or desert using immunohistochemical analysis and evaluated the tumor stroma. The excluded type was the most common, and cases with high-volume stroma in the primary lesions also had a high stromal volume in the liver metastatic lesions. Liver-metastasis mouse models with different stromal volumes were established and treatment-induced changes in the tumor immune microenvironment were evaluated. The anti-PD-1 antibody alone exhibited a therapeutic effect for the liver metastases with low stromal volumes but not for the liver metastases with high stromal volumes. In contrast, antitumor effects were observed with anti-PD-1 antibody/dasatinib combination therapy even in the liver metastases with high stromal volumes. Combination therapy reduced the stromal volume, promoted immune cell infiltration, induced antitumor cytotoxic T-cell responses, activated antitumor immunity, and promoted tumor regression. These results suggest that CAFs play an important role in the immune evasion of CRC and that anti-PD-1 antibody/dasatinib combination therapy has potential as a treatment option for patients with metastatic CRC for whom immunotherapy alone is ineffective.
- Published
- 2022
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40. Videofluorographic Analysis of Swallowing Function after Total Glossolaryngectomy.
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Kadota H, Shimamoto R, Fukushima S, Ikemura K, Kamizono K, Hanada M, Yoshida S, Fukushima J, Yasumatsu R, and Nakagawa T
- Subjects
- Adult, Aged, Aged, 80 and over, Humans, Male, Middle Aged, Barium, Retrospective Studies, Surgical Flaps, Digestive System Surgical Procedures, Female, Deglutition physiology, Pharynx diagnostic imaging, Pharynx surgery
- Abstract
Summary: Surgeons have traditionally believed that swallowing is mainly dependent on gravity after total glossolaryngectomy. However, swallowing function after total glossolaryngectomy varies widely among patients, and a thorough analysis is lacking. The authors aimed to clarify the swallowing function after total glossolaryngectomy and determine whether it is primarily dependent on gravity. The authors retrospectively analyzed videofluorographic examinations of patients who underwent total glossolaryngectomy and free or pedicle flap reconstruction. The authors enrolled 20 patients (12 male; mean age, 61 years; age range, 43 to 89 years). All patients demonstrated constriction of the reconstructed pharynx to some degree, and no patient's ability to swallow was dependent on gravity alone. Videofluorography showed excellent barium clearance in eight patients and poor clearance in 12. All patients with excellent clearance showed strong constriction of the posterior pharyngeal wall, whereas only 8.3 percent of the patients with poor clearance showed adequate constriction, which was significantly different ( p = 0.0007). Velopharyngeal closure and lip closure also contributed significantly to excellent clearance ( p = 0.041). The shape of the reconstructed pharynx (depressed, flat, protuberant) showed no statistically significant association with excellent clearance. Contrary to previous understanding, constriction of the remnant posterior pharyngeal wall played an important role in swallowing after total glossolaryngectomy, and gravity played a secondary role. Dynamic posterior pharyngeal wall movement might result from the increased power of the pharyngeal constrictor muscle and compensate for the immobility of the transferred flap. A well-functioning pharyngeal constrictor muscle and complete velopharyngeal and lip closures can contribute to excellent barium clearance in patients after total glossolaryngectomy., Clinical Question/level of Evidence: Therapeutic, III., (Copyright © 2022 by the American Society of Plastic Surgeons.)
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- 2022
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41. Investigation of endoscopic findings in nine cases of Helicobacter suis-infected gastritis complicated by gastric mucosa-associated lymphoid tissue lymphoma.
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Kadota H, Yuge R, Miyamoto R, Otani R, Takigawa H, Hayashi R, Urabe Y, Oka S, Sentani K, Oue N, Kitadai Y, and Tanaka S
- Subjects
- Gastric Mucosa pathology, Humans, Lymphoma, Non-Hodgkin, Gastritis complications, Gastritis pathology, Helicobacter Infections complications, Helicobacter Infections diagnosis, Helicobacter Infections drug therapy, Helicobacter heilmannii, Helicobacter pylori genetics, Lymphoma, B-Cell, Marginal Zone complications, Lymphoma, B-Cell, Marginal Zone pathology, Stomach Neoplasms pathology
- Abstract
Background: We have previously reported that eradication therapy was more effective against Helicobacter pylori (Hp)-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma in non-Helicobacter pylori Helicobacter (NHPH)-positive cases than in NHPH-negative cases and that the infection status of NHPH could be a predictive marker for the efficacy of eradication therapy for H. pylori negative gastric MALT lymphoma. However, a diagnostic test for NHPH infection has not yet been clinically established. In this study, we investigated the endoscopic findings in cases of H. suis-infected gastritis associated with gastric MALT lymphoma reported at our institution., Materials and Methods: Participants were selected from cases of gastric MALT lymphoma who underwent esophagogastroduodenoscopy at Hiroshima University Hospital, who were negative for the API2-MALT1 gene, and who received eradication therapy as a first-line treatment. We examined the endoscopic findings in nine cases from this group in which H. suis infection was confirmed by polymerase chain reaction., Results: Endoscopic findings, such as cracked mucosa, spotty redness, nodular gastritis-like appearance, and white marbled appearance, which have been reported as characteristics of NHPH gastritis, were observed in multiple cases. The most common endoscopic findings in this study were cracked mucosa (7/9 cases), followed by spotty redness (6/9 cases), nodular gastritis-like appearance (5/9 cases), and white marbled appearance (2/9 cases)., Conclusions: Our study may serve as a reference for re-evaluation of the diagnostic criteria for H. suis infection and indications for eradication therapy, particularly for cases of H. pylori negative gastric MALT lymphoma, where endoscopic findings such as those seen in this study were observed in the background mucosa., (© 2022 John Wiley & Sons Ltd.)
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- 2022
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42. Infrahyoid myofascial flap transfer for the prevention of concave deformity and gustatory sweating after parotidectomy.
- Author
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Kadota H and Yoshida T
- Subjects
- Aged, Humans, Male, Parotid Gland surgery, Postoperative Complications prevention & control, Retrospective Studies, Surgical Flaps, Parotid Neoplasms complications, Parotid Neoplasms surgery, Sweating, Gustatory prevention & control
- Abstract
Objective: Concave deformities and gustatory sweating are the most common complications that cause substantial patient dissatisfaction after parotidectomy. Various surgical methods to prevent these complications have been described. However, effective techniques have not been established, especially in patients with medium- to large-sized parotidectomy defects. We evaluated the utility of infrahyoid myofascial flap reconstruction of parotidectomy defects for the prevention of these complications., Methods: We conducted a retrospective case series study in patients with a benign or malignant parotid tumor measuring over 4 cm who underwent immediate pedicle infrahyoid myofascial flap reconstruction after total or subtotal parotidectomy or total resection of either the superficial or deep parotid gland at our hospital. Subjective analyses of facial symmetry, postoperative concave deformities of the anterior neck, gustatory sweating, voice disorders, odynophagia, neck scarring in the parotid and anterior neck areas, sensory disorders, pain, and neck stiffness were performed using patient interview data. Objective evaluations of facial symmetry were made by the first or second author. Both analyses were performed after a follow-up of more than six months. Additionally, patient demographic data, clinicopathological factors, parotidectomy and skin incision types, flap survival, and postoperative complications were evaluated., Results: We included eight patients (male, n=5; mean age, 69.3 years [range, 37-93 years]). Procedures included total or subtotal parotidectomy (n=4), superficial lobe parotidectomy (n=2), and deep lobe parotidectomy with partial superficial lobe parotidectomy (n=2). Infrahyoid myofascial flaps reached the cranial tip of the parotid defect without tension, and their volume sufficiently filled the parotidectomy defect in all patients. There were no local signs of insufficient blood flow within the transferred flaps. Objective and subjective assessments were made after a mean duration of 1.2 years (range, 0.6-1.8). Postoperatively, no patient subjectively reported facial asymmetry. Objectively, facial symmetry was "good" in four patients and "fair" in four patients. No distinctly visible concave deformity in the parotid or anterior neck area occurred in any patient. Gustatory sweating occurred in one patient; this individual had the largest parotidectomy defect. Only one patient experienced donor site morbidity (mild anterior neck stiffness) related to infrahyoid myofascial flap elevation., Conclusion: Although complete prevention of gustatory sweating was unsuccessful, infrahyoid myofascial flap reconstruction of medium- to large-sized parotidectomy defects led to postoperative facial symmetry with minimal donor site morbidity., Competing Interests: Declaration of Competing Interest None., (Copyright © 2021. Published by Elsevier B.V.)
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- 2022
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43. Auricular complications following temporal bone resection for temporal bone malignancies: A clinical consideration.
- Author
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Komune N, Matsuo S, Shimamoto R, Ikemura K, Iwanaga J, Sato K, Yoshida S, Kadota H, and Nakagawa T
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Bone Neoplasms surgery, Ear Auricle blood supply, Postoperative Complications prevention & control, Temporal Bone surgery
- Published
- 2021
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44. A Double-Barreled Fibular Graft for the Reconstruction of Both Forearm Bones and Humeroradial Joint after a Tumor Resection.
- Author
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Matsushita Y, Hanada M, Matsumoto Y, Kadota H, and Nakashima Y
- Subjects
- Activities of Daily Living, Humans, Radius diagnostic imaging, Radius surgery, Ulna diagnostic imaging, Ulna surgery, Fibula diagnostic imaging, Fibula surgery, Forearm surgery
- Abstract
A double-barreled fibular graft was used to reconstruct both forearm bones and the humeroradial joint after tumor resection. The patient had a tumor of radius that invaded the ulna and extensor groups. After a wide tumor resection, vascularized fibular autograft and soft tissue reconstruction was performed. A fibular graft were placed as a double barrel in the proximal ulnar and radial defects including the radial head and fixed using two locking plates. Simultaneously, reconstruction of the humeroradial joint and wrist dorsiflexion was performed. Two years postoperatively, the patient is satisfied with his elbow function while performing activities of daily living. Although amputation was one of the options considered during the preoperative planning in this case, the affected limb could be preserved by grafting a double-barreled fibula and tendon transfer, which could maintain the function of his upper left limb.
- Published
- 2021
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45. Volumetric changes of transferred free anterolateral thigh flaps in head and neck lesions.
- Author
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Kamizono KI, Yoshida S, Yasumatsu R, and Kadota H
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Intraoperative Period, Male, Middle Aged, Muscle, Skeletal physiology, Retrospective Studies, Tomography, X-Ray Computed, Adipose Tissue transplantation, Free Tissue Flaps, Head surgery, Muscle, Skeletal anatomy & histology, Neck surgery, Thigh surgery
- Abstract
Objective: The purpose of this study was to clarify sequential volumetric changes of anterolateral thigh (ALT) flaps transferred to head and neck lesions., Patients and Methods: We retrospectively analyzed volumetric changes in fat and muscle of 22 ALT flaps. We assessed "true" flap volume using the water-displacement method intraoperatively. Postoperative flap volume was assessed using three-dimensional volume-calculating software., Results: The average duration until the entire flap volume decreased to its minimal size was 8.7 months. After 8.7 months, entire flap volume decreased to 47.4% of its initial intraoperative volume. The fat volume decreased to 62.5%, and the muscle volume decreased to 30.2%. The rate of muscle volume decrease was significantly larger than that of fat volume decrease (p<0.005). The only significant factor which affected entire flap volume decrease was the recipient site where the ALT flap was transferred (oral and pharyngeal lesions) (p=0.001), and the factor that affected fat volume decrease was postoperative body-weight loss (p=0.046)., Conclusion: To minimize the influence of postoperative ALT flap volume decrease, an ALT flap should mainly comprise fatty tissue, and its size should be 1.6-times larger (100/62.5) than the ideal volume intraoperatively. Maintaining the body weight is crucial to avoid ALT flap volume decrease., Competing Interests: Declaration of Competing Interest The authors have no financial interests to declare in relation to the content of this article., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2021
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46. Lymphaticovenular anastomosis for lymph vessel injury in the pelvis and groin.
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Kadota H, Shimamoto R, Fukushima S, Inatomi Y, Ikemura K, Miyashita K, Kamizono K, Hanada M, and Yoshida S
- Subjects
- Anastomosis, Surgical, Groin surgery, Humans, Lymphography, Neoplasm Recurrence, Local, Pelvis, Retrospective Studies, Treatment Outcome, Lymphatic Vessels diagnostic imaging, Lymphatic Vessels surgery, Lymphedema surgery
- Abstract
Background: Lymphatic diseases due to lymph vessel injuries in the pelvis and groin require immediate clinical attention when conventional treatments fail. We aimed to clarify the effectiveness of and indications for lymphaticovenular anastomosis (LVA) to treat these lymphatic diseases., Methods: We retrospectively evaluated six patients who underwent LVA for lymphatic diseases due to lymph vessel injuries in the pelvis and groin. Specific pathologies included groin lymphorrhea (N = 3), chylous ascites (N = 2), and retroperitoneal lymphocele (N = 1). The maximum lymphatic fluid leakage volume was 150-2600 mL daily. Conventional treatments (compression, drainage, fasting, somatostatin administration, negative pressure wound therapy, or lymph vessel ligation) had failed to control leakage in all cases. We performed lower extremity LVAs after confirming the site of lymph vessel injury using lymphoscintigraphy. We preferentially placed LVAs in thigh sites that showed a linear pattern by indocyanine green lymphography. Postoperative lymphatic fluid leakage volume reduction was evaluated, and leakage cessation was recorded when the drainage volume approached 0 mL., Results: LVA was performed at an average of 4.3 sites (range, 3-6 sites) in the thigh and 2.7 sites (range, 0-6 sites) in the lower leg. Lymphatic fluid leakage ceased in all cases after a mean of 6 days (range, 1-11 days) postoperatively. No recurrence of symptoms was observed during an average follow-up of 2.9 (range, 0.5-5.5) years., Conclusions: LVA demonstrates excellent and rapid effects. We recommend lower extremity LVA for the treatment of lymphatic diseases due to lymph vessel injuries in the pelvis and groin., (© 2021 Wiley Periodicals LLC.)
- Published
- 2021
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47. Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy.
- Author
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Takigawa H, Yuge R, Masaki S, Otani R, Kadota H, Naito T, Hayashi R, Urabe Y, Oka S, Tanaka S, Chayama K, and Kitadai Y
- Subjects
- Adult, Aged, Aged, 80 and over, Biomarkers analysis, Female, Helicobacter Infections complications, Helicobacter Infections microbiology, Humans, Lymphoma, B-Cell, Marginal Zone genetics, Lymphoma, B-Cell, Marginal Zone microbiology, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion genetics, Stomach Neoplasms genetics, Stomach Neoplasms microbiology, Treatment Outcome, Young Adult, Anti-Bacterial Agents therapeutic use, Helicobacter drug effects, Helicobacter Infections drug therapy, Lymphoma, B-Cell, Marginal Zone drug therapy, Stomach Neoplasms drug therapy
- Abstract
Background: Eradication therapy is known to be effective against Helicobacter pylori-positive gastric MALT lymphoma but predicting the efficacy of eradication therapy against Helicobacter pylori-negative gastric MALT lymphoma is difficult. Recent reports have shown that non-Helicobacter pylori helicobacter infections induce gastric MALT lymphoma, and we aimed to clarify whether non-Helicobacter pylori helicobacter infections are associated with the efficacy of eradication therapy., Methods: We analyzed eradication therapy as a first-line treatment for 182 cases of gastric MALT lymphoma, classified according to Helicobacter pylori infection and API2-MALT1 mutation status. We also evaluated the non-Helicobacter pylori helicobacter infection status in 29 Helicobacter pylori-negative cases via PCR with DNA extracted from paraffin-embedded biopsy tissues. Finally, we analyzed the relationship between non-Helicobacter pylori helicobacter infection status and eradication therapy outcome., Results: The API2-MALT1 mutation was observed in 13/182 patients (7.1%), none of whom were cured by eradication therapy. Helicobacter pylori-negative cases had a significantly higher non-Helicobacter pylori helicobacter infection rate than Helicobacter pylori-positive cases (16/29, 55% vs. 3/29, 10%; P < 0.05). Among the Helicobacter pylori-negative cases, non-Helicobacter pylori helicobacter-positive cases had a significantly higher complete response rate than non-Helicobacter pylori helicobacter-negative cases (12/16, 75% vs. 3/13, 23%; P < 0.05)., Conclusion: Helicobacter pylori-negative and API2-MALT1-negative gastric MALT lymphoma cases exhibited a high rate of non-Helicobacter pylori helicobacter infections, which may have contributed to the success of eradication therapy. Therefore, we recommend eradication therapy as a first-line treatment for non-Helicobacter pylori helicobacter-positive gastric MALT lymphoma.
- Published
- 2021
- Full Text
- View/download PDF
48. Acquisition of novel ball-related skills associated with sports experience.
- Author
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Sekiguchi H, Yamanaka K, Takeuchi S, Futatsubashi G, Kadota H, Miyazaki M, and Nakazawa K
- Subjects
- Athletic Performance psychology, Exercise, Female, Humans, Male, Sports psychology, Transcranial Magnetic Stimulation, Young Adult, Athletic Performance physiology, Motor Skills physiology, Psychomotor Performance physiology, Pyramidal Tracts physiology, Sports physiology
- Abstract
Some individuals can quickly acquire novel motor skills, while others take longer. This study aimed to investigate the relationships between neurophysiological state, sports experience, and novel ball-related skill acquisition. We enrolled 28 healthy collegiate participants. The participants' neurophysiological data (input-output curve of the corticospinal tract) were recorded through transcranial magnetic stimulation. Subsequently, the participants performed a novel motor task (unilateral two-ball juggling) on a different day, after which they reported their previous sports experience (types and years). We found that individuals with more years of experience in ball sports showed faster acquisition of novel ball-related skills. Further, this result was not limited to any single ball sport. Therefore, the acquisition of novel ball-related skills is associated with familiarity with a ball's nature. Furthermore, gain of the corticospinal tract was negatively and positively correlated with the years of experience in primary ball and non-ball sports (implemented for the longest time in individuals), respectively. These results could be associated with the extent of proficiency in their primary sport. The chosen type of sports (e.g., ball or non-ball) could critically influence the future acquisition of novel motor skills. This study provides important insights regarding how to approach sports and physical activities.
- Published
- 2021
- Full Text
- View/download PDF
49. Gastric mucosa-associated lymphoid tissue lymphoma in conjunction with multiple lymphomatous polyposis in the context of Helicobacter pylori and Helicobacter suis superinfection.
- Author
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Naito T, Yuge R, Tanaka S, Otani R, Kadota H, Takigawa H, Tamura T, Sentani K, Yasui W, Kitadai Y, and Chayama K
- Subjects
- Anti-Bacterial Agents therapeutic use, Female, Humans, Middle Aged, Helicobacter Infections complications, Helicobacter Infections drug therapy, Helicobacter heilmannii, Helicobacter pylori, Lymphoma, B-Cell, Marginal Zone drug therapy, Stomach Neoplasms drug therapy, Superinfection drug therapy
- Abstract
A 53-year-old woman visited a doctor and complained of chest discomfort after meals. Esophagogastroduodenoscopy showed multiple granular elevations in the gastric body. After biopsies from the elevations, she was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma. Polymerase chain reaction also detected Helicobacter pylori and H. suis. Treatment to eradicate H. pylori and H. suis was successful. Endoscopic examination after the bacterial eradication treatment showed that multiple granular elevations remained in the gastric body; however, no lymphoma cells were found during histopathological examination. Thus, we reported a case of H. pylori-positive gastric MALT lymphoma with a unique morphology associated with H. suis superinfection.
- Published
- 2021
- Full Text
- View/download PDF
50. Successful Management of a Severe Sacral Pressure Injury Penetrating to the Retroperitoneum.
- Author
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Kadota H, Miyashita K, Fukushima S, Oryoji C, Hanada M, Yoshida S, Fujita H, and Tachibana Y
- Subjects
- Female, Humans, Middle Aged, Bandages, Retroperitoneal Space, Sacrococcygeal Region, Negative-Pressure Wound Therapy, Pressure Ulcer, Sacrum
- Abstract
Introduction: Reports of retroperitoneal infection related to a sacral pressure injury (PI) are rare, and none of the reports described the direct spread of infection through the sacrum to the retroperitoneum. The authors present, to their knowledge, the first report of a severely infected PI that showed full-thickness sacral destruction and direct retroperitoneal penetration., Case Report: A 63-year-old female was referred for management of a stage 4 sacral PI complicated by a retroperitoneal abscess. The patient's comorbidities were diabetes mellitus and pemphigus foliaceus with steroid therapy-induced immunosuppression. Upon admission, the patient presented with a sacral PI producing copious purulent discharge that measured 5 cm × 3 cm. Magnetic resonance imaging revealed full-thickness sacral bone destruction and a massive retroperitoneal abscess, suggesting the sacral PI directly penetrated to the retroperitoneal space. Antibiotics were administered, and surgical debridement and sequestrectomy were performed. Negative pressure wound therapy (NPWT) with continuous saline irrigation was initiated. The patient's mesorectum was exposed within the retroperitoneal space. Therefore, a nonadhesive wound dressing was applied before placing the irrigation tube to avoid perforating the rectum. Because the patient had fragile skin secondary to long-standing pemphigus foliaceus and steroid treatment, a liquid skin protectant and hydrocolloid wound dressing were applied. The infection was successfully controlled with NPWT with saline irrigation. The patient experienced no rectal injury or skin rupture, and surgical closure was performed after 75 days. Although partial wound dehiscence occurred because of the poor condition of the skin, the resultant open wound was managed conservatively. The patient showed no retroperitoneal abscess recurrence 6 months later., Conclusions: A rare case of an intractable sacral PI complicated by retroperitoneal abscess was successfully managed in an immunocompromised patient. Notably, NPWT with saline irrigation was useful in controlling the patient's severe retroperitoneal infection.
- Published
- 2021
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