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1. Investigation on interferon alpha-inducible protein 6 (IFI6) gene as a candidate for meat and carcass quality in pig

Author: Mehmet Ulas Cinar, Chirawath Phatsara, A. Kayan, Karl Schellander, Christian Looft, Klaus Wimmers, Christine Große-Brinkhaus, Ernst Tholen, D. Tesfaye, Muhammad Jasim Uddin, S. Ponsuksili, and H. Juengst
Subjects: Candidate gene, Meat, Genotype, Cell Survival, Swine, Population, Fluorescent Antibody Technique, Muscle Proteins, Biology, Loin, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Gene Frequency, Western blot, medicine, Animals, Myocyte, RNA, Messenger, Food science, Muscle, Skeletal, education, Gene, Alleles, education.field_of_study, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, Malignant hyperthermia, Chromosome Mapping, food and beverages, Skeletal muscle, Anatomy, medicine.disease, medicine.anatomical_structure, Food Science
Abstract: The aim of this research was to screen for polymorphism and to perform an association study of IFI6 with meat and carcass quality traits. A SNP (g.370A>G) was detected which was associated (P < 0.05) with meat colour, pH 24 h post mortem (p.m.) in ham, conductivity 45 min p.m. in loin and conductivity 24 h p.m. in ham, drip loss and carcass length in Duroc × Pietrain and with meat colour, muscle area and ham percentage in the Pietrain population. Highest expression of IFI6 mRNA was detected in skeletal muscle (longissimus dorsi) by qRT-PCR comparing different tissues. Both qRT-PCR and western blot revealed that the IFI6 gene and protein expressions were significantly (P < 0.05) higher in skeletal muscle with low drip loss compared to that of high drip loss. IFI6 protein was localized in the myocytes membrane. Results suggested that IFI6 might play roles in meat and carcass quality and is a potential positional, physiological and functional candidate gene for improving meat quality traits in pigs.
Published: 2011
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2. Combined line-cross and half-sib QTL analysis in Duroc–Pietrain population

Author: H. Juengst, Elisebeth Jonas, Liu Guisheng, Jong-Joo Kim, Karl Schellander, Ernst Tholen, Dawit Tesfaye, Siriluck Ponsuksili, Chirawath Phatsara, Eduard Murani, Klaus Wimmers, and Ji Lan Chen
Subjects: Male, Meat, Swine, Quantitative Trait Loci, Population, Quantitative trait locus, Biology, symbols.namesake, Quantitative Trait, Heritable, Genetics, Animals, Carcass composition, Allele, education, Allele frequency, Crosses, Genetic, education.field_of_study, Genome, Models, Genetic, Hydrogen-Ion Concentration, Chromosomes, Mammalian, Breed, Qtl analysis, Mendelian inheritance, symbols, Female
Abstract: A Duroc-Pietrain resource population was built to detect quantitative trait loci (QTL) that affect growth, carcass composition, and pork quality. The data were analyzed by applying three least-squares Mendelian models: a line-cross (LC) model, a half-sib (HS) model, and a combined LC and HS model (CB), which enabled the detection of QTL that had fixed, equal, and different allele frequencies for alternate breed alleles, respectively. Permutation tests were performed to determine 5% chromosome-wide and 5% genome-wide threshold values. A total of 40 (137) QTL were detected at the 5% genome-wide (chromosome-wide) level for the 35 traits analyzed. Of the 137 QTL detected, 62 were classified as the LC type (LC-QTL), 47 as the HS type (HS-QTL), and 28 as the CB type (CB-QTL). The results indicate that implementation of a series of model-based framework is not only beneficial to detect QTL, but also provides us with a new and more robust interpretation from which further methodology could be developed.
Published: 2008
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3. Electroproduction of kaons on light nuclei

Author: R. Sawafta, J. H. Liu, John C. Mitchell, T. Eden, C. Yan, D. G. Meekins, E. Christy, F. Dohrmann, P. Ambrozewicz, L. Cole, M. Sarsour, A. Ahmidouch, Y. Sato, P. E. Reimer, S. Tajima, J. A. Dunne, J. Roche, S. Danagoulian, Kevin Bailey, B. Mueller, J. W. Price, W. Hinton, N. S. Chant, H. Mkrtchyan, J. Crowder, H. Juengst, Haiyan Gao, John Arrington, G. Savage, C. Cothran, J. P. Schiffer, B. Zihlmann, M. Zeier, H. C. Fenker, J.-O. Hansen, Paul Gueye, Rolf Ent, R. D. Carlini, Brian Raue, R. Asaturyan, L. Gan, W. J. Cummings, A. Semenov, D. F. Geesaman, J. Cha, D. S. Brown, M. Elaasar, A. Cochran, H. Breuer, Dipangkar Dutta, Pete Markowitz, L. Yuan, J. Reinhold, H. Bitao, A. Uzzle, K. Gustafsson, B. Terburg, F. Duncan, S. Stepanyan, P. G. Roos, Ketevi Assamagan, Avraham Klein, G. Collins, Thomas O'Neill, D. Potterveld, V. Tadevosian, K. Garrow, H. E. Jackson, D. Koltenuk, C. S. Armstrong, Y. Liang, O. K. Baker, I. Niculescu, B. Zeidman, A. F. Lung, G. Niculescu, Toshinobu Miyoshi, H. Yamaguchi, R. Madey, D. Abbott, L. Ewell, H. T. Fortune, Y. Fujii, K. Hafidi, R. E. Segel, S. Beedoe, S. Mtingwa, C. J. Martoff, R. Mohring, C. E. Keppel, S. A. Wood, D. J. Mack, Stephen Avery, and L. G. Tang
Subjects: Physics, Nuclear and High Energy Physics, Meson, Proton, Helium-3, Hadron, Production (computer science), Elementary particle, Atomic physics, Nuclear Experiment, Lambda, Isotopes of helium
Abstract: The A(e,e{prime}K{sup +})YX reaction on H, D, {sup 3}He, and {sup 4}He was investigated in Hall C at CEBAF. Data were obtained for Q{sup 2} {approx} 0.35 and 0.5 GeV{sup 2} at 3.245 GeV. The missing mass spectra for both H and D are fitted with Monte-Carlo simulations incorporating peaks corresponding to {Lambda} production on the proton and {Sigma} production on both the proton and neutron. For D, the cross section ratio {Sigma}{sup 0}/{Sigma}{sup {minus}} {approx} 2, and excess yield close to the thresholds for {Lambda} and {Sigma} production can be attributed to final-state interactions that are compared to the data. The analysis of the data for the He targets is in a more preliminary state with broader quasi-free peaks resulting from the higher Fermi momenta. Evidence for bound {Lambda}-hypernuclear states is seen and other structure may be present.
Published: 2001
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4. The construction and operating characteristics of a cathode strip chamber system designed to measure the reaction vertices of a stopping kaon beam

Author: J. H. Liu, M. Youn, Anton Empl, Christopher Morris, Miroslav Furić, Jen-Chieh Peng, M. W. Ahmed, Adam Rusek, E. V. Hungerford, J. M. O’Donnell, V. Zeps, D. Dehnhard, J. Bjoraker, R. E. Chrien, C. M. Riedel, H. Juengst, X. Cui, J. Gerald, R. J. Sutter, Darko Androić, Mirko Planinic, I. Bertovic, Henry A. Thiessen, K. J. Lan, P. Pile, L. G. Tang, Tomislav Petković, and R. L. Gill
Subjects: Physics, cathode-strip detector, stopped kaons, hypernucleus, NMS, Nuclear and High Energy Physics, Photon, Physics::Instrumentation and Detectors, Measure (physics), Alternating Gradient Synchrotron, Hypernucleus, Cathode, Vertex (geometry), law.invention, Nuclear physics, Beamline, law, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment, Instrumentation, Beam (structure)
Abstract: The design, construction, and performance of a segmented-target, cathode-strip, tracking-detector is discussed. The chamber was made of low- Z materials in order to allow photons to leave the target region. It was used to determine the reaction vertex of stopping kaons, and was successfully operated in a high-intensity kaon beamline at the Alternating Gradient Synchrotron at Brookhaven National Laboratory. The vertical and horizontal resolutions of the stopping kaon reaction positions were σ X ∼0.454 mm and σ Y ∼1.180 mm , respectively. The uncertainty in the longitudinal ( Z ) direction is given by one-half the thickness of a target segment.
Published: 2001
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5. Electroproduction of kaons and light hypernuclei

Author: John C. Mitchell, Y. Liang, T. Eden, Thomas O'Neill, D. F. Geesaman, R. E. Segel, L. Ewell, J. Cha, H. Bitao, E. Christy, Ketevi Assamagan, M. Sarsour, J. Crowder, L. Cole, J. W. Price, S. Danagoulian, Dipangkar Dutta, H. Juengst, H. Yamaguchi, H.T. Fortune, D. Koltenuk, N. Chant, J. H. Liu, D. Abbott, R. Asaturyan, D. G. Meekins, W. Hinton, T. Miyoshi, J. Roche, Brian Raue, Paul Gueye, W. U. Boeglin, J. Reinhold, Pete Markowitz, J.-O. Hansen, L. G. Tang, R. Mohring, R. Sawafta, K. Garrow, J. P. Schiffer, C. E. Keppel, C. J. Martoff, C. Cothran, John Arrington, Kevin Bailey, C. Yan, B. Zihlmann, H. C. Fenker, B. Terburg, C. S. Armstrong, P. Roos, Y. Sato, Rolf Ent, S. Tajima, B. Mueller, P. Ambrozewicz, G. Savage, S. Stepanyan, D. S. Brown, A. Uzzle, O. K. Baker, Avraham Klein, A. Cochran, H. Mkrtchyan, A. Semenov, L. Gan, W. J. Cummings, G. Collins, F. Duncan, K. Gustafsson, F. Dohrmann, Y. Fujii, R. Madey, M. Zeier, J. A. Dunne, A. Ahmidouch, R. D. Carlini, S. A. Wood, A. F. Lung, D. J. Mack, L. Yuan, S. Beedoe, M. Elaasar, Stephen Avery, G. Niculescu, I. Niculescu, D. Potterveld, V. Tadevosian, S. Mtingwa, H. Breuer, K. Hafidi, Haiyan Gao, H. E. Jackson, P. E. Reimer, B. Zeidman, and (Astro)-Particles Physics
Subjects: Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, Deuterium, Production (computer science), Electron, Nucleon, Fundamental interaction
Abstract: A detailed investigation of the basic hyperon-nucleon interactions in nuclei is one of the aims of Experiment 91-016, approved with high priority at CEBAF, to study the electroproduction of kaons on targets of deuterium, {sup 3}He, and {sup 4}He. Inasmuch as both the electron and K{sup +} are particles that interact relatively weakly with nucleons, electroproduction of light hypernuclei provides a low-distortion method for investigating the fundamental interactions between nucleons, {Alpha}`s, and {Epsilon}`s in few-body systems. In particular, the (e,e`K{sup +}) reactions on cryogenic targets of D, {sup 3}He, and {sup 4}He will be studied at incident electron energies near 3 GeV with coincident detection of the emergent e and K{sup +} in the HMS and SOS magnetic spectrometers in Hall C. Construction of the He target, operating at {approximately}10 atm, {approximately}50 K and capable of dissipating {approximately}30 W, is expected to be complete prior to commencement of production runs in Hall C. The first data runs for E91-016, expected to begin late in FY 1995, will also be the basis for a doctoral thesis at Hampton University. In addition to providing new information on the phases of hyperon-nucleon interactions, measurements of cross sections for hypernuclear formation, and interference phenomena,more » the data may provide evidence for the presence of bound {Epsilon}`s and strange di-baryonic states that are the subject of considerable theoretical discussion.« less
Published: 2001
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6. Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population

Author: Watchara Laenoi, Elisabeth Jonas, Christine Große-Brinkhaus, Helga Sauerwein, Ernst Tholen, H. Juengst, Mehmet Ulas Cinar, Klaus Wimmers, Armin M. Scholz, Muhammad Jasim Uddin, Chirawath Phatsara, Dawit Tesfaye, Christian Looft, M. Mielenz, and Karl Schellander
Subjects: Genetic Markers, Bone density, lcsh:QH426-470, Quantitative Trait Loci, Sus scrofa, Population, Breeding, Quantitative trait locus, Biology, Crossbreed, Bone Density, Genetics, medicine, Animals, Osteochondrosis, Genetics(clinical), education, Crosses, Genetic, Ecology, Evolution, Behavior and Systematics, lcsh:SF1-1100, Bone mineral, education.field_of_study, Muscle Weakness, Foot, Research, Ulna, Chromosome Mapping, Muscle weakness, General Medicine, Anatomy, medicine.disease, body regions, lcsh:Genetics, medicine.anatomical_structure, Animal Science and Zoology, lcsh:Animal culture, medicine.symptom
Abstract: Background Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs. Methods Three hundred and ten F2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software. Results Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level. Conclusions Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
Published: 2011

7. Mapping quantitative trait loci for innate immune response in the pig

Author: M J, Uddin, M U, Cinar, C, Grosse-Brinkhaus, D, Tesfaye, E, Tholen, H, Juengst, C, Looft, K, Wimmers, C, Phatsara, and K, Schellander
Subjects: Genetic Markers, Vaccines, Phenotype, Quantitative Trait, Heritable, Models, Genetic, Quantitative Trait Loci, Sus scrofa, Toll-Like Receptors, Vaccination, Animals, Chromosome Mapping, Cytokines, Immunity, Innate
Abstract: The aim of the present study was to detect quantitative trait loci (QTL) for the serum levels of cytokines and Toll-like receptors as traits related to innate immunity in pig. For this purpose, serum concentration of interleukin 2 (IL2), interleukin 10 (IL10), interferon-gamma (IFNG), Toll-like receptor 2 (TLR2) and Toll-like receptor 9 (TLR9) were measured in blood samples obtained from F(2) piglets (n = 334) of a Duroc × Piétrain resource population (DUPI) after Mycoplasma hypopneumoniae (Mh), tetanus toxoid (TT) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccination at 6, 9 and 15 weeks of age. Animals were genotyped at 82 genetic markers covering all autosomes. QTL analysis was performed under the line cross F(2) model using QTL Express and 33 single QTL were detected on almost all porcine autosomes. Among the single QTL, eight, twelve and thirteen QTL were identified for innate immune traits in response to Mh, TT and PRRSV vaccine, respectively. Besides single QTL, six QTL were identified by a two-QTL model, of which two for TLR9_TT were in coupling phase and one for IL10_PRRSV was in repulsion phase. All QTL were significant at 5% chromosome-wide level including one and seven at 5% genome- and 1% chromosome-wide level significance. All innate immune traits are influenced by multiple chromosomal regions implying multiple gene action. Some of the identified QTL coincided with previously reported QTL for immune response and disease resistance, and the newly identified QTL are potentially involved in the immune function. The immune traits were also influenced by environmental factors like year of birth, age, parity and litter size. The results of this work shed new light on the genetic background of innate immune response and these findings will be helpful to identify candidate genes in these QTL regions related to immune competence and disease resistance in pigs.
Published: 2011

8. Mapping of quantitative trait loci for mycoplasma and tetanus antibodies and interferon-gamma in a porcine F-2 Duroc x Pietrain resource population

Author: Klaus Wimmers, C. Grosse-Brinkhaus, Elisabeth Jonas, Dawit Tesfaye, H. Juengst, Siriluck Ponsuksili, Christian Looft, Mehmet Ulas Cinar, Muhammad Jasim Uddin, Karl Schellander, Chirawath Phatsara, and Ernst Tholen
Subjects: Candidate gene, Swine, Population, Quantitative Trait Loci, Quantitative trait locus, Antibodies, Interferon-gamma, Mycoplasma, Mycoplasma hyopneumoniae, Genetic linkage, Genetics, Animals, education, Crosses, Genetic, education.field_of_study, Autosome, Tetanus, biology, Vaccination, Chromosome Mapping, food and beverages, biology.organism_classification, Genetics, Population, Phenotype, Genetic marker, Antibody Formation, Microsatellite
Abstract: The aim of the present study was to detect quantitative trait loci (QTL) for innate and adaptive immunity in pigs. For this purpose, a Duroc x Pietrain F(2) resource population (DUPI) with 319 offspring was used to map QTL for the immune traits blood antibodies and interferon-gamma using 122 microsatellites covering all autosomes. Antibodies response to Mycoplasma hyopneumoniae and tetanus toxoid vaccine and the interferon-gamma (IFNG) serum concentration were measured at three different time points and were used as phenotypes. The differences of antibodies and interferon concentration between different time points were also used for the linkage mapping. Line-cross and imprinting QTL analysis, including two-QTL, were performed using QTL Express. A total of 30 QTL (12, 6, and 12 for mycoplasma, tetanus antibody, and IFNG, respectively) were identified at the 5% chromosome-wide-level significant, of which 28 were detected by line-cross and 2 by imprinting model. In addition, two QTL were identified on chromosome 5 using the two-QTL approach where both loci were in repulsion phase. Most QTL were detected on pig chromosomes 2, 5, 11, and 18. Antibodies were increased over time and immune traits were found to be affected by sex, litter size, parity, and month of birth. The results demonstrated that antibody and IFNG concentration are influenced by multiple chromosomal areas. The flanking markers of the QTL identified for IFNG on SSC5 did incorporate the position of the porcine IFNG gene. The detected QTL will allow further research in these QTL regions for candidate genes and their utilization in selection to improve the immune response and disease resistance in pig.
Published: 2010

9. Verification of chromosomal regions affecting the innate immunity in pigs using linkage mapping

Author: K, Wimmers, E, Jonas, H-J, Schreinemachers, D, Tesfaye, S, Ponsuksili, E, Tholen, H, Juengst, K, Schellander, and C, Phatsara
Subjects: Genetic Linkage, Quantitative Trait Loci, Mycoplasma hyopneumoniae, Animals, Chromosome Mapping, Complement System Proteins, Antibodies, Bacterial, Immunity, Innate
Abstract: Understanding the genetic control of innate immunity in pigswould offerthe opportunity to utilize natural variation and improve selective breeding programmes. As part of our porcine genome scan to identify quantitative trait loci (QTL) we examined immune response traits in a Duroc x Berlin miniature pig resource family (DUMI). Complement activity via classical (CH50) and alternative (AH50) pathways, antibody response to Mycoplasma hyopneumoniae (Mh), tetanus toxoid (TET) and PRRS virus (PRRSV), the complement component (C3c), and Haptoglobin serum concentration (HP) were used as phenotypes for linkage mapping. A total of 220 backcross animals were used for the QTL analysis. Blood was collected six times from each animal prior to and after vaccinations against Mycoplasma hyopneumoniae, tetanus toxoid and PRRS, respectively. Seventy-four microsatellites from 18 autosomes were used for QTL mapping. The analyses were performed treating the measurements of phenotypes at different time points as single traits. Forty-two significant and 24 highly significant QTL were detected, using the program QTL Express, for all immune traits using the single traits. Most QTL were detected on SSC3, SSC16, and SSC18. No significant F-value corresponded to data for SSC12 and SSC13.
Published: 2008

10. Physiological Interactions between the Endocrine and Immune Systems Shown in Gene Analysis in Pigs

Author: Klaus Wimmers, S. Ponsuksili, Heiko Buschbell, H. Juengst, D. Tesfaye, Chirawath Phatsara, Karl Schellander, Saowaluck Yammuen-art, Elisabeth Jonas, and Ernst Tholen
Subjects: endocrine system, medicine.medical_specialty, Growth factor, medicine.medical_treatment, Prolactin receptor, Peptide hormone, Biology, Growth hormone–releasing hormone, Prolactin, Classical complement pathway, Endocrinology, Internal medicine, medicine, Alternative complement pathway, Hormone
Abstract: A number of observations support the concept of important physiological interactions between the endocrine and immune systems. It could be confirmed that hormones secreted by the neuroendocrine system play an important role in communication and regulation of the cells of the immune system. Among protein hormones, this has been most clearly documented for prolactin (PRL), growth hormone (GH), and insulin-like growth factor 1 (IGF-1). A number of traits of the immune response in a Duroc x Berlin Miniature pig family (DUMI) were examined. The haemolytic complement activity in the classical complement pathway (CH50) and the alternative pathway (AH50)was examined at eight different time points in pigs that were vaccinated with different vaccines. Single nucleotide polymorphism (SNP) genotyping was employed to genotype the DUMI F2 animal for growth hormone (Gh), growth hormone releasing hormone (Ghrh), pituitary-specific transcription factor 1 (Pit1), and prolactin receptor (Prlr) loci, and also a microsatellite within insulin-like growth factor 1 (Igf1). Using a family-based association test (FBAT) program, a highly significant association of Gh, Pit1, and Prlr to AH50 (p < or = 0.01) and a significant association of Pit1 to CH50 (p < or = 0.05) were found. Using the SAS system for mixed model, a highly significant association of Gh, and Igf1 to AH50 and CH50 (p < or = 0.01) was detected, while Prlr and Ghrh had a highly significant association (p < or = 0.01) with CH50 only.
Published: 2008
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11. Verification of Chromosomal Regions Affecting the Innate Immunity in Pigs Using Linkage Mapping

Author: H.-J. Schreinemachers, Elisabeth Jonas, H. Juengst, Karl Schellander, Ernst Tholen, Chirawath Phatsara, D. Tesfaye, Klaus Wimmers, and S. Ponsuksili
Subjects: Genetics, Immune system, Mycoplasma hyopneumoniae, Genetic linkage, Toxoid, Microsatellite, Genome Scan, Quantitative trait locus, Biology, Selective breeding, biology.organism_classification
Abstract: Understanding the genetic control of innate immunity in pigs would offer the opportunity to utilize natural variation and improve selective breeding programmes. As part of our porcine genome scan to identify quantitative trait loci (QTL) we examined immune response traits in a Duroc x Berlin miniature pig resource family (DUMI). Complement activity via classical (CH50) and alternative (AH50) pathways, antibody response to Mycoplasma hyopneumoniae (Mh), tetanus toxoid (TET) and PRRS virus (PRRSV), the complement component (C3c), and Haptoglobin serum concentration (HP) were used as phenotypes for linkage mapping. A total of 220 backcross animals were used for the QTL analysis. Blood was collected six times from each animal prior to and after vaccinations against Mycoplasma hyopneumoniae, tetanus toxoid and PRRS, respectively. Seventy-four microsatellites from 18 autosomes were used for QTL mapping. The analyses were performed treating the measurements of phenotypes at different time points as single traits. Forty-two significant and 24 highly significant QTL were detected, using the program QTL Express, for all immune traits using the single traits. Most QTL were detected on SSC3, SSC16, and SSC18. No significant F-value corresponded to data for SSC12and SSC13.
Published: 2008
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12. Search for Medium Modifications of theρMeson

Author: S. A. Morrow, C. Djalali, C. Hanretty, A.V. Stavinsky, P. Ambrozewicz, D. J. Tedeschi, Baile Zhang, M. J. Amaryan, H. Juengst, R. A. Miskimen, B. McKinnon, M. MacCormick, Shifeng Chen, I. Bedlinskiy, Carlos A. Salgado, I. Hleiqawi, Andreas Klein, Ji Li, S. L. Careccia, D. Branford, L. Casey, B. B. Niczyporuk, N. Pivnyuk, Nikolay Shvedunov, M. Mirazita, J. M. Laget, K. L. Giovanetti, P. Collins, E. L. Isupov, N. Markov, J. Salamanca, Mark Richard James Williams, J. W C McNabb, Larry Weinstein, J. T. Goetz, S. Boiarinov, K. A. Griffioen, B. M. Preedom, S. McAleer, C. E. Hyde-Wright, J. P. Cummings, S. Niccolai, L. Elouadrhiri, S. Mehrabyan, H. Denizli, F. X. Girod, L. Blaszczyk, R. J. Feuerbach, Lorenzo Zana, J. Hardie, E. De Sanctis, Jens H. Kuhn, I. I. Strakovsky, A. I. Ostrovidov, K. Park, R. A. Schumacher, N. A. Baltzell, M. Khandaker, Dinko Pocanic, D. G. Ireland, V. Crede, Sergey Kuleshov, J. P. Santoro, M. Bektasoglu, H. Hakobyan, Federico Ronchetti, H. S. Jo, G. Riccardi, P. Muehlich, A. Deur, M. Kossov, Gerald Feldman, Volker D. Burkert, A. S. Biselli, S. E. Kuhn, J. R. Calarco, M. Guidal, Z. Krahn, L. C. Smith, E. Munevar, G. Ricco, D. I. Sober, S. Strauch, Rakhsha Nasseripour, K. Moriya, L. Todor, D. Doughty, C. Butuceanu, D. Protopopescu, N. Dashyan, G. Niculescu, M. Holtrop, N. Baillie, Mestayer, M. Battaglieri, B. S. Ishkhanov, S. Pozdniakov, M. Garçon, P. Eugenio, D. P. Watts, H. Egiyan, M. Taiuti, J. D. Kellie, R. C. Minehart, C. A. Meyer, B. Carnahan, S. Tkachenko, C. I O Gordon, F. Sabatié, V. Sapunenko, Laird Kramer, R. Bradford, B. A. Mecking, A. V. Vlassov, J. Langheinrich, G. V. Fedotov, N. Kalantarians, N. Benmouna, M. Ripani, M. Nozar, Yordanka Ilieva, Michael Vineyard, R. De Vita, Gerard Gilfoyle, M. Anghinolfi, Ulrich Mosel, J. J. Melone, Brian Raue, K. Livingston, James Mueller, D. P. Weygand, D. Sokhan, Cynthia Marie Hadjidakis, E. S. Smith, Maryam Moteabbed, M. R. Niroula, Alexei V. Klimenko, S. Anefalos Pereira, D. G. Jenkins, G. S. Mutchler, Michael Dugger, H. O. Funsten, Y. G. Sharabian, K. V. Dharmawardane, E. Wolin, B. L. Berman, S. Stepanyan, L. C. Dennis, R. Dickson, Sylvain Bouchigny, Barry Ritchie, J. P. Ball, Y. Prok, D. S. Carman, P. Rossi, C. Paterson, D. G. Crabb, J. Pierce, H. Avakian, P. Mattione, D. Sharov, N. Guler, G. E. Dodge, H. Y. Lu, P. V. Degtyarenko, S. Barrow, I. Niculescu, D. Lawrence, R. De Masi, P. Coltharp, William Brooks, Hall Crannell, M. M. Ito, S. Bültmann, W. J. Briscoe, E. Pasyuk, J. R. Johnstone, L. Guo, M. Ungaro, S. A. Dytman, M. Bellis, K. Joo, S. S. Stepanyan, A. Yegneswaran, V. Gyurjyan, J. Zhang, H. Bagdasaryan, J. W. Price, V. P. Kubarovsky, G. Rosner, O. Pogorelko, Frank Klein, Michael Wood, K. Hafidi, K. S. Egiyan, V. S. Serov, B. E. Stokes, G. S. Adams, K. Mikhailov, Clarisse Tur, P. Nadel-Turonski, Tsutomu Mibe, G. Gavalian, V. Mokeev, P. Stoler, W. Kim, J. Lachniet, K. Hicks, A. Tkabladze, R. S. Hakobyan, L. El Fassi, M. Osipenko, G. Asryan, O. P. Dzyubak, R. A. Niyazov, P. L. Cole, Z. W. Zhao, B. Zhao, F. W. Hersman, and R. W. Gothe
Subjects: Physics, Particle physics, Rho meson, Meson, Spectrometer, Nuclear Theory, Spectrum (functional analysis), General Physics and Astronomy, Order (ring theory), Physics and Astronomy(all), Resonance (particle physics), medicine.anatomical_structure, Deuterium, medicine, High Energy Physics::Experiment, Nuclear Experiment, Nucleus
Abstract: The photoproduction of vector mesons on various nuclei has been studied using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Laboratory. The vector mesons, $$\rho$$, $$\omega$$, and $$\phi$$, are observed via their decay to $e^+e^-$, in order to reduce the effects of final state interactions in the nucleus. Of particular interest are possible in-medium effects on the properties of the $$\rho$$ meson. The $$\rho$$ spectral function is extracted from the data on various nuclei, carbon, iron, and titanium, and compared to the spectrum from liquid deuterium, which is relatively free of nuclear effects. We observe no significant mass shift for the $$\rho$$ meson; however, there is some widening of the resonance in titanium and iron, which is consistent with expected collisional broadening.
Published: 2007
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13. QuasifreeΛ,Σ0, andΣ−electroproduction fromH1,2,He3,4, and carbon

Author: Y. Sato, B. Mueller, L. Gan, S. Tajima, N. S. Chant, S. Danagoulian, E. Christy, H. Juengst, J. Crowder, K. Hafidi, L. Cole, R. Asaturyan, M. Sarsour, John C. Mitchell, Toshinobu Miyoshi, P. E. Reimer, Pete Markowitz, H. Breuer, Brian Raue, J. Cha, John Arrington, G. Niculescu, Kevin Bailey, C. S. Armstrong, A. Uzzle, Chenyu Yan, H. Yamaguchi, J. Roche, S. A. Wood, R. D. Carlini, B. Zeidman, W. Hinton, H. Mkrtchyan, L. Yuan, Y. Fujii, F. Dohrmann, D. H. Potterveld, M. Zeier, A. Ahmidouch, D. J. Mack, S. Mtingwa, Stephen Avery, M. Elaasar, R. E. Segel, C. E. Keppel, H. Bitao, H. C. Fenker, A. Semenov, Y. Liang, I. Niculescu, Paul Gueye, D. F. Geesaman, S. Stepanyan, L. G. Tang, V. Tadevosyan, B. Zihlmann, J. H. Liu, K. Garrow, A. Lung, J. Reinhold, Rolf Ent, D. S. Brown, and A. Cochran
Subjects: Physics, Nuclear and High Energy Physics, Hydrogen, Nuclear Theory, Hyperon, chemistry.chemical_element, Sigma, Particle accelerator, Few-body systems, Lambda baryon, Lambda, law.invention, Nuclear physics, Deuterium, chemistry, law, High Energy Physics::Experiment, Nuclear Experiment
Abstract: Kaon electroproduction from light nuclei and hydrogen, using $^{1}\mathrm{H}$, $^{2}\mathrm{H}$, $^{3}\mathrm{He}$, $^{4}\mathrm{He}$, and carbon targets has been measured at the Thomas Jefferson National Accelerator Facility. The quasifree angular distributions of \ensuremath{\Lambda} and \ensuremath{\Sigma} hyperons were determined at ${Q}^{2}=0.35$ (GeV/$c$)${}^{2}$ and $W=1.91$ GeV. Electroproduction on hydrogen was measured at the same kinematics for reference.
Published: 2007
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14. Erratum: Cross sections for theγp→K*0Σ+reaction atEγ=1.7−3.0GeV [Phys. Rev. C75, 042201 (2007)]

Author: Shifeng Chen, L. C. Dennis, M. Osipenko, H. Avakian, K. Livingston, K. Beard, K. A. Griffioen, J. Donnelly, G. Asryan, M. Battaglieri, R. Bradford, B. A. Mecking, O. P. Dzyubak, R. A. Niyazov, H. Egiyan, J. T. Goetz, R. Dickson, D. Doughty, G. Rosner, Carlos A. Salgado, J. W C McNabb, D. Heddle, A.V. Stavinsky, A. V. Vlassov, Maryam Moteabbed, W. J. Briscoe, E. Pasyuk, K. S. Egiyan, E. S. Smith, D. G. Jenkins, W. Kim, Laird Kramer, D. J. Tedeschi, Kwangsoo Kim, J. Lachniet, A. Tkabladze, S. A. Dytman, S. E. Kuhn, B. B. Niczyporuk, G. Riccardi, K. Mikhailov, B. L. Berman, M. Amarian, N. Guler, R. De Vita, I. Bedlinskiy, Andreas Klein, J. Langheinrich, B. E. Stokes, V. Sapunenko, C. Butuceanu, Sylvain Bouchigny, N. Pivnyuk, E. Wolin, Stephen Taylor, K. Lukashin, Ji Li, U. Thoma, C. Paterson, M. Bellis, P. Rossi, Gerard Gilfoyle, S. McAleer, F. X. Girod, S. A. Morrow, G. Gavalian, P. Stoler, R. S. Hakobyan, V. Batourine, S. Niccolai, C. Djalali, J. P. Ball, D. G. Ireland, M. D. Mestayer, V. Crede, G. Ricco, Y. Prok, V. Mokeev, D. S. Carman, J. Hardie, M. MacCormick, B. Carnahan, F. Sabatié, K. Hicks, J. R. Calarco, P. Ambrozewicz, Michael L. Williams, I. Hleiqawi, S. L. Careccia, V. P. Kubarovsky, S. Strauch, Atilla Gonenc, H. Juengst, D. G. Crabb, J. P. Cummings, G. S. Mutchler, M. Guidal, Z. Krahn, L. C. Smith, E. Munevar, N. A. Baltzell, E. De Sanctis, O. Pogorelko, K. L. Giovanetti, G. Niculescu, R. W. Gothe, N. Baillie, R. A. Miskimen, B. McKinnon, M. Anghinolfi, Larry Weinstein, B. S. Ishkhanov, S. Boiarinov, D. I. Sober, D. Branford, L. Elouadrhiri, M. R. Niroula, Yordanka Ilieva, M. Mirazita, J. M. Laget, M. Kossov, Frank Klein, I. I. Strakovsky, J. D. Kellie, A. Deur, R. G. Fersch, Rakhsha Nasseripour, M. Holtrop, Michael Dugger, B. Zhao, M. Khandaker, Brian Raue, P. Coltharp, Y. G. Sharabian, M. M. Ito, A. I. Ostrovidov, Michael Wood, K. Park, Michael Vineyard, Hong Lu, P. L. Cole, Z. W. Zhao, F. W. Hersman, S. Whisnant, B. M. Preedom, V. S. Serov, Federico Ronchetti, Lorenzo Zana, Volker D. Burkert, A. S. Biselli, Clarisse Tur, P. Nadel-Turonski, H. S. Jo, Tsutomu Mibe, Gerald Feldman, C. E. Hyde-Wright, R. C. Minehart, K. Wang, C. A. Meyer, K. Moriya, R. J. Feuerbach, Jens H. Kuhn, Sergey Kuleshov, S. Tkachenko, N. Benmouna, V. Gyurjyan, M. Ripani, G. V. Fedotov, N. Kalantarians, L. Todor, J. Zhang, H. Bagdasaryan, D. Protopopescu, J. W. Price, L. Guo, S. Pozdniakov, M. Garçon, M. Ungaro, K. Joo, S. S. Stepanyan, A. Yegneswaran, D. P. Weygand, Alexei V. Klimenko, Barry Ritchie, G. E. Dodge, P. V. Degtyarenko, I. Niculescu, D. Lawrence, R. De Masi, R. A. Schumacher, M. Nozar, S. Bültmann, S. Stepanyan, J. Pierce, William Brooks, Hall Crannell, P. Eugenio, M. Taiuti, P. Collins, J. P. Santoro, and Roy Thompson
Subjects: Baryon, Nuclear reaction, Physics, Nuclear and High Energy Physics, Particle physics, Meson, Hadron, Elementary particle, Fermion, Boson, Sigma baryon
Published: 2007
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15. QTL for the heritable inverted teat defect in pigs

Author: D. Tesfaye, Karl Schellander, H. Juengst, Heinz-Josef Schreinemachers, Elisabeth Jonas, Cemal Ün, Sylvio Tetzlaff, Danyel Jennen, Ina Oltmanns, Siriluck Ponsuksili, Ernst Tholen, Eduard Murani, Tina Kleinwächter, and Klaus Wimmers
Subjects: Linkage (software), Genetics, Male, education.field_of_study, Population, Positional candidate, Quantitative Trait Loci, Sus scrofa, food and beverages, Quantitative trait locus, Biology, Chromosomes, Mammalian, Mammary Glands, Animal, Quantitative Trait, Heritable, Family-based QTL mapping, Genetic linkage, Animals, Female, education, Gene, Allele frequency, Crosses, Genetic
Abstract: The mothering ability of a sow largely depends on the shape and function of the mammary gland. The aim of this study was to identify QTL for the heritable inverted teat defect, a condition characterized by disturbed development of functional teats. A QTL analysis was conducted in a porcine experimental population based on Duroc and Berlin Miniature pigs (DUMI). The significant QTL were confirmed by linkage analysis in commercial pigs according to the affected sib pair design and refined by family-based association test (FBAT). Nonparametric linkage (NPL) analysis revealed five significant and seven suggestive QTL for the inverted teat defect in the porcine experimental population. In commercial dam lines five significant NPL values were detected. QTL regions in overlapping marker intervals or close proximity in both populations were found on SSC3, SSC4, SSC6, and SSC11. SSC6 revealed QTL in both populations at different positions, indicating the segregation of at least two QTL. The results confirm the previously proposed polygenic inheritance of the inverted teat defect and, for the first time, point to genomic regions harboring relevant genes. The investigation revealed variation of the importance of QTL in the various populations due to either differences in allele frequencies and statistical power or differences in the genetic background that modulates the impact of the liability loci on the expression of the disease. The QTL study enabled us to name a number of plausible positional candidate genes. The correspondence of QTL regions for the inverted teat defect and previously mapped QTL for teat number are in line with the etiologic relationship of these traits.
Published: 2007

16. A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population

Author: Eduard Murani, H. Juengst, Liu Guisheng, Tina Kleinwächter, H.-J. Schreinemachers, Karl Schellander, Klaus Wimmers, Michael Hölker, Siriluck Ponsuksili, G. Ün, Danyel Jennen, Jong-Joo Kim, Ernst Tholen, Dawit Tesfaye, Gezondheidsrisico Analyse en Toxicologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, and RS: NUTRIM - R4 - Gene-environment interaction
Subjects: Meat, Population, Quantitative Trait Loci, Sus scrofa, Quantitative trait locus, Biology, Breeding, symbols.namesake, Genetic linkage, Genetics, Animals, education, Crosses, Genetic, education.field_of_study, Autosome, food and beverages, Chromosome Mapping, General Medicine, Phenotypic trait, Genomics, Phenotype, Mendelian inheritance, symbols, Trait, Body Composition, Microsatellite, Animal Science and Zoology, Microsatellite Repeats
Abstract: We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.
Published: 2007

17. Erratum:η′Photoproduction on the Proton for Photon Energies from 1.527 to 2.227 GeV [Phys. Rev. Lett.96, 062001 (2006)]

Author: Laird Kramer, Dinko Pocanic, G. S. Mutchler, S. E. Kuhn, G. Rosner, Stephen Taylor, Yordanka Ilieva, M. D. Mestayer, J. J. Manak, P. Eugenio, M. Osipenko, Shifeng Chen, M. Taiuti, S. Boiarinov, B. M. Preedom, M. Guidal, G. Niculescu, K. Beard, K. Livingston, K. S. Egiyan, M. Holtrop, R. A. Schumacher, Lorenzo Zana, Frank Klein, K. Mikhailov, M. Guillo, J. T. Goetz, J. Langheinrich, S. A. Philips, K. A. Griffioen, V. Batourine, D. G. Ireland, V. Crede, S. A. Morrow, P. Rubin, L. Elouadrhiri, A.V. Stavinsky, H. S. Jo, Gerald Feldman, J. R. Calarco, N. Guler, G. Gavalian, C. Djalali, G. Audit, C. E. Hyde-Wright, R. J. Feuerbach, M. Bektasoglu, J. Shaw, N. A. Baltzell, I. I. Strakovsky, B. Carnahan, F. Sabatié, K. Wang, B. E. Stokes, G. S. Adams, D. J. Tedeschi, V. Mokeev, J. P. Cummings, J. Hu, E. Wolin, P. Ambrozewicz, Michael Wood, A. Deur, J. Donnelly, G. Asryan, S. Barrow, O. P. Dzyubak, R. A. Niyazov, H. Juengst, V. S. Serov, R. A. Miskimen, B. McKinnon, I. Bedlinskiy, M. Anghinolfi, G. V. O'Rielly, J. P. Ball, Y. Prok, M. Kossov, Andreas Klein, K. V. Dharmawardane, M. Nozar, P. Corvisiero, James Mueller, Rakhsha Nasseripour, K. S. Dhuga, D. Branford, J. P. Santoro, M. Bellis, E. S. Smith, Marco A. Huertas, D. S. Carman, A. Coleman, H. R. Weller, Roy Thompson, D. Protopopescu, T. A. Forest, D. G. Jenkins, J. D. Kellie, Y. G. Sharabian, Cynthia Marie Hadjidakis, E. De Sanctis, M. Mirazita, J. M. Laget, M. Battaglieri, P. Collins, M. Spraker, V. Gyurjyan, A. I. Ostrovidov, P. Stoler, A. C S Lima, K. Park, L. C. Smith, S. Pozdniakov, M. Garçon, B. S. Ishkhanov, P. L. Cole, Michael Vineyard, A. Shafi, Mark Richard James Williams, S. Stepanyan, Sylvain Bouchigny, R. Bradford, B. A. Mecking, P. Rossi, R. DeVita, J. Zhang, V. P. Kubarovsky, D. G. Crabb, Michael Dugger, Volker D. Burkert, H. Egiyan, J. Pierce, J. W C McNabb, K. Hicks, W. Kim, Clarisse Tur, P. Nadel-Turonski, H. Bagdasaryan, J. W. Price, V. Sapunenko, Valeria Muccifora, A. Empl, O. Pogorelko, A. S. Biselli, P. Dragovitsch, D. I. Sober, S. McAleer, F. X. Girod, Tsutomu Mibe, B. L. Berman, H. O. Funsten, S. Niccolai, L. M. Qin, Gerard Gilfoyle, B. B. Niczyporuk, William Brooks, U. Thoma, L. C. Dennis, B. E. Bonner, P. Coltharp, N. Pivnyuk, K. Lukashin, J. Napolitano, Hall Crannell, H. Avakian, M. M. Ito, J. Hardie, S. Strauch, Jens H. Kuhn, C. Paterson, Nicola Bianchi, L. C. Maximon, C. Marchand, M. Klusman, J. Lachniet, A. Tkabladze, L. Guo, M. Ungaro, G. E. Dodge, D. Rowntree, P. V. Degtyarenko, K. Kim, S. Bültmann, W. J. Briscoe, E. Pasyuk, K. Joo, J. Yun, D. Cords, S. S. Stepanyan, N. Baillie, S. A. Dytman, R. S. Hakobyan, R. Fatemi, A. Yegneswaran, D. Lawrence, A. V. Vlassov, Kwangsoo Kim, G. Riccardi, C. Butuceanu, S. Tkachenko, N. Benmouna, T. Lee, M. Ripani, Carlos A. Salgado, G. Ricco, Brian Raue, Federico Ronchetti, R. C. Minehart, C. A. Meyer, G. V. Fedotov, D. P. Weygand, D. Doughty, H. Denizli, D. Heddle, A. V. Skabelin, Alexei V. Klimenko, Barry Ritchie, E. Anciant, M. Khandaker, I. Hleiqawi, S. L. Careccia, S. Simionatto, K. L. Giovanetti, B. Asavapibhop, Larry Weinstein, F. W. Hersman, and R. W. Gothe
Subjects: Physics, Nuclear physics, Meson production, Photon, Proton, General Physics and Astronomy
Published: 2006
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18. Erratum: Radiative decays of theΣ0(1385)andΛ(1520)hyperons [Phys. Rev. C71, 054609 (2005)]

Author: A. V. Vlassov, T. Lee, M. Spraker, Michael Vineyard, G. V. O'Rielly, B. E. Stokes, G. S. Adams, D. G. Jenkins, B. S. Raue, J. P. Santoro, R. DeVita, J. W C McNabb, L. Todor, Roy Thompson, Kwangsoo Kim, G. Riccardi, C. Butuceanu, D. Protopopescu, S. Pozdniakov, M. Garçon, E. Wolin, J. P. Ball, Y. Prok, D. S. Carman, D. G. Crabb, Yordanka Ilieva, Ji Li, W. Kim, J. P. Cummings, R. A. Schumacher, L. Elouadrhiri, M. Kossov, Rakhsha Nasseripour, K. S. Egiyan, I. I. Strakovsky, V. Koubarovski, C. I O Gordon, M. Bellis, K. Mikhailov, M. M. Ito, M. Nozar, A. Deur, E. De Sanctis, L. Morand, T. A. Forest, S. Stepanyan, Federico Ronchetti, D. I. Sober, A. Empl, O. Pogorelko, L. C. Dennis, B. E. Bonner, G. Ricco, G. S. Mutchler, H. Avakian, V. Batourine, C. A. Meyer, E. Golovatch, G. Asryan, S. Bültmann, B. Carnahan, O. P. Dzyubak, R. A. Niyazov, W. J. Briscoe, E. Pasyuk, F. Sabatié, J. D. Kellie, S. A. Dytman, M. D. Mestayer, J. J. Manak, P. Corvisiero, M. Anghinolfi, U. Thoma, H. R. Weller, G. E. Dodge, Frank Klein, James Mueller, P. V. Degtyarenko, K. Kim, K. V. Dharmawardane, L. C. Smith, J. Shaw, D. P. Weygand, Michael Wood, Y. G. Sharabian, S. A. Morrow, P. Stoler, I. Niculescu, A. Shafi, P. Rubin, C. Djalali, S. Boiarinov, D. Lawrence, M. Guillo, J. Langheinrich, K. Hicks, V. S. Serov, M. Osipenko, S. A. Philips, Shifeng Chen, William Brooks, G. Rosner, Hall Crannell, H. Denizli, V. Sapunenko, C. Marchand, Valeria Muccifora, B. L. Berman, M. Battaglieri, L. M. Qin, P. Ambrozewicz, F. W. Hersman, H. Juengst, A. I. Ostrovidov, A. C S Lima, K. Park, Gerard Gilfoyle, E. Polli, M. Klusman, R. W. Gothe, G. Audit, C. E. Hyde-Wright, A. V. Skabelin, R. J. Feuerbach, Dinko Pocanic, M. Bektasoglu, Alexei V. Klimenko, R. Bradford, B. A. Mecking, Volker D. Burkert, A. S. Biselli, S. E. Kuhn, Cynthia Marie Hadjidakis, B. M. Preedom, M. Guidal, Barry Ritchie, G. Niculescu, P. Eugenio, Stephen Taylor, S. McAleer, M. Taiuti, K. A. Griffioen, Michael Dugger, M. Holtrop, H. O. Funsten, B. B. Niczyporuk, S. Strauch, J. J. Melone, Laird Kramer, D. G. Ireland, N. Pivnyuk, Lorenzo Zana, J. R. Calarco, K. Lukashin, J. Napolitano, R. A. Miskimen, Carlos A. Salgado, D. Branford, J. Hu, Gerald Feldman, M. Mirazita, J. M. Laget, K. Wang, N. Benmouna, M. Ripani, E. S. Smith, Marco A. Huertas, Sylvain Bouchigny, P. Rossi, Mark Richard James Williams, P. Dragovitsch, S. Niccolai, J. Hardie, A.V. Stavinsky, D. J. Tedeschi, K. Beard, Andreas Klein, G. Gavalian, V. Mokeev, D. Doughty, D. Heddle, J. Lachniet, A. Tkabladze, H. Egiyan, E. Anciant, C. S. Whisnant, D. Rowntree, M. Khandaker, V. Gyurjyan, K. Livingston, R. S. Hakobyan, N. Guler, H. Bagdasaryan, J. W. Price, L. Guo, S. Barrow, M. Ungaro, I. Hleiqawi, K. Joo, J. Yun, D. Cords, S. S. Stepanyan, A. Yegneswaran, R. G. Fersch, S. Simionatto, P. L. Cole, K. L. Giovanetti, B. Asavapibhop, Larry Weinstein, Clarisse Tur, Jens H. Kuhn, Nicola Bianchi, R. Suleiman, and R. Fatemi
Subjects: Nuclear physics, Physics, Nuclear and High Energy Physics, Hyperon, Radiative decay, Radiative transfer, Sigma, Lambda, Particle identification
Published: 2005
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19. High-resolution kaon spectrometer (HKS) for medium-heavy Mass Λ-hypernuclear structure studies at the Jlab (E01-011 Collaboration)

Author: L. G. Tang, L. Cole, K. J. Lan, A. Daniel, Pavlo Baturin, D. Dehnhard, S. A. Wood, A. Uzzle, W. F. Vulcan, T. Angelescu, H. Yamaguchi, C. Yan, V.P. Likhachev, Miroslav Furić, O. K. Baker, Satoshi Nakamura, D. J. Mack, Y. Fujii, E. V. Hungerford, Amur Margaryan, Kyo Tsukada, Seigo Kato, H. C. Fenker, S. Wells, M. Planinić, T. Takahashi, G. R. Smith, Yoichi Sato, S. Danagoulian, H. Juengst, Kazushige Maeda, R. Asaturyan, V. Tadevosyan, Toshio Motoba, Osamu Hashimoto, Hiroyuki Noumi, Pete Markowitz, Y. Okayasu, A. Ahmidouch, T. Miyoshi, Rolf Ent, H. Kanda, Tomislav Petković, C. E. Keppel, L. Yuan, L. Gan, H. Mkrtchyan, T. Seva, Hirokazu Tamura, Ashot Gasparian, R. D. Carlini, I. Bertovic, V. M. Rodriguez, S. Stepanyan, Guo-Lin Xu, P. Gueye, Darko Androić, Neven Simicevic, Joerg Reinhold, and M. E. Christy
Subjects: Nuclear reaction, Nuclear physics, Physics, Particle physics, Meson, Resolution (mass spectrometry), Spectrometer, Hadron, Hyperon, Spectroscopy, Lambda baryon
Abstract: An experimental technique for single‐Λ spectroscopy of the light and medium‐heavy mass Λ‐hypernuclei developed at the Jlab by the E01‐011 Collaboration has been described. The technique is based on the electroproduction of Λ‐hypernuclei by the (e,e′K+) reaction and newly constructed 2nd generation high resolution large solid angle kaon spectrometer (HKS).
Published: 2005
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20. Electroproduction of strangeness on [sub Λ][sup 3,4]H bound states on Helium

Author: A. Lung, L. Cole, Rolf Ent, A. Yu. Semenov, D. S. Brown, A. Cochran, H. E. Jackson, John C. Mitchell, R. Asaturyan, K. Gustafsson, Joerg Reinhold, H. C. Fenker, K. Garrow, J. Roche, T. Eden, J. Crowder, P. E. Reimer, G. Collins, Pete Markowitz, Thomas O'Neill, S. A. Wood, H. Breuer, W. Hinton, J.-O. Hansen, Brian Raue, J. A. Dunne, L. A. Ewell, F. Dohrmann, A. Uzzle, P. Ambrozewicz, C. J. Martoff, I. Niculescu, J. W. Price, D. J. Mack, H. Bitao, C. Yan, M. Sarsour, E. Christy, D. H. Potterveld, M. Elaasar, Paul Gueye, A. Ahmidouch, S. Beedoe, L. G. Tang, D. F. Geesaman, Stephen Avery, F. Duncan, H. Mkrtchyan, C. Cothran, R. Sawafta, Y. Liang, L. Yuan, S. Stepanyan, B. Zihlmann, P. G. Roos, Avraham Klein, S. Mtingwa, R. E. Segel, M. Zeier, Kevin Bailey, J. H. Liu, V. Tadevosian, J. Cha, B. Terburg, S. Tajima, R. Mohring, D. G. Meekins, R. Madey, Dipangkar Dutta, N. S. Chant, S. Danagoulian, H. Juengst, G. Savage, C. E. Keppel, G. Niculescu, Ketevi Assamagan, R. D. Carlini, B. Mueller, L. Gan, W. J. Cummings, H. Yamaguchi, J. Arrington, C. S. Armstrong, D. Abbott, D. Koltenuk, Y. Fujii, Haiyan Gao, B. Zeidman, Toshinobu Miyoshi, Yoichi Sato, H. T. Fortune, and K. Hafidi
Subjects: Physics, Particle physics, chemistry.chemical_element, Particle accelerator, Strangeness, Lambda baryon, Lambda, law.invention, Nuclear physics, Helium-4, chemistry, law, Helium-3, Bound state, Helium
Abstract: The A(e,e'K+)X reaction has been investigated at Jefferson Laboratory. Data were taken for Q2 {approx_equal} 0.35 GeV2 at a beam energy of 3.245 GeV for 1H,3He and 4He targets. Evidence for {lambda}-hypernuclear bound states is seen for 3,4He targets. This is the first time that the electroproduction of these hypernuclei has been observed.
Published: 2005
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21. Publisher's Note: Angular Distributions forHΛ3,4Bound States in theHe3,4(e,e′K+)Reaction [Phys. Rev. Lett.93, 242501 (2004)]

Author: J. Cha, R. Asaturyan, Yoichi Sato, J. Crowder, Pete Markowitz, S. A. Wood, H. Mkrtchyan, B. Zeidman, Brian Raue, D. J. Mack, C. S. Armstrong, Y. Fujii, D. H. Potterveld, Stephen Avery, H. Bitao, L. Cole, R. E. Segel, Kevin Bailey, G. Niculescu, A. Uzzle, B. Mueller, H. C. Fenker, H. Yamaguchi, B. Zihlmann, A. Semenov, S. Danagoulian, C. E. Keppel, J. H. Liu, H. Juengst, M. Sarsour, S. Mtingwa, M. Zeier, J. Reinhold, John C. Mitchell, F. Dohrmann, C. Yan, L. G. Tang, R. D. Carlini, E. Christy, J. Arrington, L. Yuan, K. Hafidi, D. F. Geesaman, S. Stepanyan, M. Elaasar, I. Niculescu, P. Gueye, Rolf Ent, D. S. Brown, A. Cochran, A. Ahmidouch, A. F. Lung, K. Garrow, P. E. Reimer, V. Tadevosian, W. Hinton, Y. Liang, H. Breuer, S. Tajima, N. S. Chant, L. Gan, J. Roche, and Toshinobu Miyoshi
Subjects: Physics, General Physics and Astronomy
Published: 2004
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22. Angular Distributions forHΛ3,4Bound States in theHe3,4(e,e′K+)Reaction

Author: L. G. Tang, J. H. Liu, S. Danagoulian, H. Juengst, C. E. Keppel, H. C. Fenker, L. Cole, G. Niculescu, A. Uzzle, A. Semenov, R. D. Carlini, K. Hafidi, F. Dohrmann, M. Sarsour, C. Yan, P. E. Reimer, S. Mtingwa, S. Tajima, H. Mkrtchyan, D. F. Geesaman, J. Arrington, N. S. Chant, R. E. Segel, K. Garrow, B. Mueller, J. Crowder, S. Stepanyan, L. Gan, J. Roche, H. Breuer, Toshinobu Miyoshi, E. Christy, H. Bitao, Brian Raue, S. A. Wood, Yoichi Sato, P. Gueye, B. Zihlmann, M. Elaasar, I. Niculescu, V. Tadevosian, A. Ahmidouch, D. J. Mack, R. Asaturyan, Stephen Avery, J. Reinhold, Rolf Ent, Pete Markowitz, A. F. Lung, D. S. Brown, W. Hinton, A. Cochran, Y. Liang, Y. Fujii, D. H. Potterveld, B. Zeidman, J. Cha, C. S. Armstrong, H. Yamaguchi, L. Yuan, M. Zeier, John C. Mitchell, and Kevin Bailey
Subjects: Physics, General Physics and Astronomy
Published: 2004
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23. Angular distributions for (3,4)(Lambda)H bound states in the (3,4)He(e,e(')K+) reaction

Author: F, Dohrmann, A, Ahmidouch, C S, Armstrong, J, Arrington, R, Asaturyan, S, Avery, K, Bailey, H, Bitao, H, Breuer, D S, Brown, R, Carlini, J, Cha, N, Chant, E, Christy, A, Cochran, L, Cole, J, Crowder, S, Danagoulian, M, Elaasar, R, Ent, H, Fenker, Y, Fujii, L, Gan, K, Garrow, D F, Geesaman, P, Gueye, K, Hafidi, W, Hinton, H, Juengst, C, Keppel, Y, Liang, J H, Liu, A, Lung, D, Mack, P, Markowitz, J, Mitchell, T, Miyoshi, H, Mkrtchyan, S K, Mtingwa, B, Mueller, G, Niculescu, I, Niculescu, D, Potterveld, B A, Raue, P E, Reimer, J, Reinhold, J, Roche, M, Sarsour, Y, Sato, R E, Segel, A, Semenov, S, Stepanyan, V, Tadevosian, S, Tajima, L, Tang, A, Uzzle, S, Wood, H, Yamaguchi, C, Yan, L, Yuan, B, Zeidman, M, Zeier, and B, Zihlmann
Abstract: The (3,4)(Lambda)H and (4)(Lambda)H hypernuclear bound states have been observed for the first time in kaon electroproduction on (3,4)He targets. The production cross sections have been determined at Q(2)=0.35 GeV2 and W=1.91 GeV. For either hypernucleus the nuclear form factor is determined by comparing the angular distribution of the (3,4)He(e,e(')K+)(3,4)(Lambda)H processes to the elementary cross section 1H(e,e K+)Lambda on the free proton, measured during the same experiment.
Published: 2004

24. Publisher’s Note: Two-Nucleon Momentum Distributions Measured inHe3(e,e′pp)n[Phys. Rev. Lett.PRLTAO0031-900792, 052303 (2004)]

Author: K. A. Griffioen, Shifeng Chen, G. Gavalian, S. McAleer, Y. Kuang, J. Langheinrich, Cynthia Marie Hadjidakis, S. A. Philips, E. Wolin, E. Polli, Michael Dugger, R. DeVita, H. O. Funsten, J. W C McNabb, S. Strauch, J. P. Ball, Y. Prok, P. L. Cole, D. S. Carman, Dinko Pocanic, V. Gyurjyan, H. Bagdasaryan, J. W. Price, Min Suk Kim, J. R. Calarco, R. A. Schumacher, Frank Klein, S. E. Kuhn, J. P. Cummings, J. Hu, C. A. Meyer, G. S. Mutchler, J. H. Kelley, Stephen Taylor, R. Fatemi, Carlos A. Salgado, C. I O Gordon, Patrick Girard, J. Shaw, Federico Ronchetti, G. Audit, C. E. Hyde-Wright, S. A. Morrow, P. Rubin, M. Eckhause, C. Djalali, A. V. Vlassov, D. G. Crabb, L. Ciciani, M. Nozar, Michael Wood, G. V. O'Rielly, R. J. Feuerbach, J. Lachniet, L. Morand, D. Rowntree, M. Kossov, T. A. Forest, V. S. Serov, G. Ricco, S. Stepanyan, P. Ambrozewicz, H. Juengst, M. Osipenko, J. R. Ficenec, M. Bektasoglu, Rakhsha Nasseripour, N. Dashyan, D. G. Jenkins, M. Bellis, K. Sabourov, M. Anghinolfi, K. Park, Shalev Gilad, S. Simionatto, E. S. Smith, James Mueller, K. Beard, R. S. Hakobyan, E. De Sanctis, P. Eugenio, L. C. Smith, B. Carnahan, G. E. Dodge, F. Sabatié, D. P. Weygand, M. Guidal, Y. G. Sharabian, Sylvain Bouchigny, Yordanka Ilieva, D. I. Sober, P. Dragovitsch, Ji Li, Brian Raue, P. Rossi, G. Niculescu, Daijin Kim, P. V. Degtyarenko, K. Kim, Volker D. Burkert, A. S. Biselli, B. B. Niczyporuk, W. Kim, M. Taiuti, N. Pivnyuk, K. L. Giovanetti, B. Asavapibhop, S. Niccolai, A. Empl, O. Pogorelko, M. Holtrop, M. D. Mestayer, J. J. Manak, Clarisse Tur, K. Lukashin, J. Napolitano, L. C. Dennis, I. Niculescu, D. Lawrence, Laird Kramer, Alexei V. Klimenko, Larry Weinstein, B. E. Bonner, Thierry Auger, J. Hardie, H. Avakian, G. Asryan, O. P. Dzyubak, R. A. Niyazov, N. Benmouna, M. Ripani, D. Doughty, K. V. Dharmawardane, S. Boiarinov, S. Mehrabyan, Barry Ritchie, D. Heddle, Kwangsoo Kim, G. Riccardi, William Brooks, Hall Crannell, C. Butuceanu, P. Corvisiero, M. Spraker, C. Cetina, Michael Vineyard, J. D. Kellie, K. S. Dhuga, C. Marchand, B. M. Preedom, J. J. Melone, William Bertozzi, E. Anciant, B. L. Berman, L. M. Qin, E. Pasyuk, M. Khandaker, K. Wang, J. P. Santoro, M. Klusman, S. A. Dytman, Roy Thompson, M. Battaglieri, P. Stoler, A. Coleman, S. O. Nelson, H. Denizli, H. R. Weller, K. Hicks, K. S. Egiyan, R. Bradford, B. A. Mecking, K. Mikhailov, A. V. Skabelin, M. M. Ito, H. Egiyan, S. McLauchlan, C. S. Whisnant, G. S. Adams, L. Todor, D. Protopopescu, S. Pozdniakov, A. Shafi, U. Thoma, Jens H. Kuhn, Nicola Bianchi, K. Livingston, W. Ingram, F. W. Hersman, G. A. Peterson, M. Guillo, S. Barrow, R. W. Gothe, L. Elouadrhiri, R. A. Miskimen, I. I. Strakovsky, L. Guo, M. Ungaro, K. Joo, D. Branford, J. Yun, D. Cords, A. Yegneswaran, M. Mirazita, J. M. Laget, V. Sapunenko, Valeria Muccifora, A.V. Stavinsky, D. J. Tedeschi, Gerard Gilfoyle, Andreas Klein, and Baile Zhang
Subjects: Physics, Momentum (technical analysis), General Physics and Astronomy, Few-body systems, Nucleon, Mathematical physics
Published: 2004
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25. Publisher’s Note: Observation of an Exotic Baryon withS=+1in Photoproduction from the Proton [Phys. Rev. Lett.PRLTAO0031-900792, 032001 (2004)]

Author: K. Park, Clarisse Tur, Volker D. Burkert, A. K. Opper, Shifeng Chen, A. S. Biselli, M. Osipenko, U. Thoma, L. C. Smith, K. Beard, S. J. Gaff, R. W. Major, B. Carnahan, F. Sabatié, E. Polli, G. V. O'Rielly, B. M. Preedom, J. Lachniet, D. Rowntree, L. Elouadrhiri, V. Gyurjyan, J. P. Santoro, L. Ciciani, K. A. Griffioen, S. Simionatto, D. G. Jenkins, Roy Thompson, K. Sabourov, Thierry Auger, K. L. Giovanetti, B. Asavapibhop, Larry Weinstein, Dinko Pocanic, I. I. Strakovsky, G. Gavalian, V. Mokeev, R. S. Hakobyan, Brian Raue, S. E. Kuhn, K. Wang, R. C. Minehart, R. A. Miskimen, C. A. Meyer, J. Langheinrich, E. De Sanctis, V. V. Frolov, J. H. Kelley, Stephen Taylor, H. Bagdasaryan, S. A. Philips, G. S. Adams, F. W. Hersman, S. McAleer, G. A. Peterson, J. P. Cummings, O. P. Dzyubak, R. A. Niyazov, D. Branford, M. Mirazita, J. W. Price, L. Guo, M. Ungaro, S. Barrow, B. L. Berman, John T. O'Brien, W. Kim, M. Kossov, D. I. Sober, P. L. Cole, P. Dragovitsch, J. M. Laget, L. M. Qin, Laird Kramer, H. Egiyan, D. P. Weygand, P. Corvisiero, Alexei V. Klimenko, R. Fatemi, J. R. Ficenec, Rakhsha Nasseripour, L. Todor, D. Protopopescu, William Brooks, A. V. Vlassov, P. Eugenio, M. Taiuti, M. Anghinolfi, S. Strauch, S. Niccolai, Hall Crannell, S. Pozdniakov, M. Garçon, C. S. Whisnant, Federico Ronchetti, James Mueller, M. Spraker, C. Cetina, Frank Klein, G. S. Mutchler, Barry Ritchie, J. Hardie, Michael Vineyard, A. Longhi, J. R. Calarco, R. DeVita, J. W C McNabb, Y. G. Sharabian, R. W. Gothe, M. Guidal, M. Klusman, M. Guillo, N. Benmouna, A.V. Stavinsky, J. J. Melone, A. Weisberg, P. Stoler, J. Hu, K. Joo, C. Marchand, Ji Li, M. Ripani, G. Niculescu, Carlos A. Salgado, S. A. Morrow, P. Rubin, J. Yun, D. Cords, A. Shafi, M. D. Mestayer, P. Heimberg, C. Djalali, D. J. Tedeschi, A. Yegneswaran, Patrick Girard, J. J. Manak, J. Shaw, S. O. Nelson, K. Hicks, Michael Wood, S. Boiarinov, M. Holtrop, Thomas E. Smith, R. A. Schumacher, E. S. Smith, K. S. Egiyan, P. Ambrozewicz, V. S. Serov, K. Mikhailov, Cynthia Marie Hadjidakis, H. Denizli, Sylvain Bouchigny, H. Juengst, Michael Dugger, H. O. Funsten, C. I O Gordon, P. Rossi, L. Farhi, M. Nozar, M. Bellis, M. U. Mozer, L. Morand, T. A. Forest, S. Stepanyan, G. Audit, V. Sapunenko, G. E. Dodge, J. Connelly, A. V. Skabelin, K. V. Dharmawardane, R. J. Feuerbach, P. V. Degtyarenko, K. Kim, V. P. Kubarovsky, Valeria Muccifora, I. Niculescu, D. Lawrence, M. Bektasoglu, A. Empl, B. B. Niczyporuk, O. Pogorelko, D. Hancock, N. Pivnyuk, K. Lukashin, J. Napolitano, L. C. Dennis, Gerard Gilfoyle, Jens H. Kuhn, Nicola Bianchi, H. Avakian, M. M. Ito, W. J. Briscoe, M. Battaglieri, E. Pasyuk, S. A. Dytman, R. Bradford, B. A. Mecking, E. Anciant, M. Khandaker, D. Doughty, D. Heddle, Yordanka Ilieva, S. Mehrabyan, Kwangsoo Kim, G. Riccardi, C. Butuceanu, E. Wolin, J. P. Ball, Y. Prok, D. S. Carman, M. Sargsyan, and D. G. Crabb
Subjects: Nuclear physics, Physics, Particle physics, Proton, Exotic baryon, Hyperon, General Physics and Astronomy
Published: 2004
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26. Electroproduction of Strangeness on Light Nuclei

Author: F. DOHRMANN, D. ABBOTT, A. AHMIDOUCH, P. AMBROZEWICZ, C.S. ARMSTRONG, J. ARRINGTON, R. ASATURYAN, K. ASSAMAGAN, S. AVERY, K. BAILEY, O.K. BAKER, S. BEEDOE, H. BITAO, H. BREUER, D.S. BROWN, R. CARLINI, J. CHA, N. CHANT, E. CHRISTY, A. COCHRAN, L. COLE, G. COLLINS, C. COTHRAN, J. CROWDER, W.J. CUMMINGS, S. DANAGOULIAN, F. DUNCAN, J. DUNNE, D. DUTTA, T. EDEN, M. ELAASAR, R. ENT, L. EWELL, H. FENKER, H.T. FORTUNE, Y. FUJII, L. GAN, H. GAO, K. GARROW, D.F. GEESAMAN, P. GUEYE, K. GUSTAFSSON, K. HAFIDI, J.O. HANSEN, W. HINTON, H.E. JACKSON, H. JUENGST, C. KEPPEL, A. KLEIN, D. KOLTENUK, Y. LIANG, J.H. LIU, A. LUNG, D. MACK, R. MADEY, P. MARKOWITZ, C.J. MARTOFF, D. MEEKINS, J. MITCHELL, T. MIYOSHI, H. MKRTCHYAN, R. MOHRING, S.K. MTINGWA, B. MUELLER, T.G. O’NEILL, G. NICULESCU, I. NICULESCU, D. POTTERVELD, J.W. PRICE, B.A. RAUE, P.E. REIMER, J. REINHOLD, J. ROCHE, P. ROOS, M. SARSOUR, Y. SATO, G. SAVAGE, R. SAWAFTA, R.E. SEGEL, A.YU. SEMENOV, S. STEPANYAN, V. TADEVOSIAN, S. TAJIMA, L. TANG, B. TERBURG, A. UZZLE, S. WOOD, H. YAMAGUCHI, C. YAN, L. YUAN, M. ZEIER, B. ZEIDMAN, and B. ZIHLMANN
Subjects: Physics, Light nucleus, Electroproduction, Nuclear Theory, Strangeness, Hyperons, Spectral function, Nuclear physics, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Nuclear Experiment, Hypernuclear boundstates, Electroproduction of strangeness, Nuclear targets
Abstract: The A(e,e'K+)YX reaction has been investigated in Hall C at Jefferson Laboratory for 6 different targets. Data were taken for Q2)approx 0.35 and 0.5 GeV2) at a beam energy of 3.245GeV for 1)H, 2)H, 3)He, 4)He, C and Al targets. The missing mass spectra are fitted with Monte Carlo simulations taking into account the production of Lambda and Sigma0) hyperon production off the proton, and Sigma-) off the neutron. Models for quasifree production are compared to the data, excess yields close to threshold are attributed to FSI. Evidence for Lambda-hypernuclear bound states is seen for 3,4)He targets.
Published: 2004

27. Experimental study of theC12(Kstopped−,π0)BΛ12reaction

Author: M. W. Ahmed, X. Cui, A. Empl, E. V. Hungerford, K. J. Lan, M. Youn, R. E. Chrien, R. Gill, P. Pile, A. Rusek, R. Sutter, J. Bjoraker, D. Dehnhard, J. M. O’Donnell, J. Gerald, H. Juengst, J. H. Liu, J. C. Peng, C. L. Morris, C. M. Riedel, H. A. Thiessen, D. Androic, I. Bertovic, M. Furic, T. Petkovic, M. Planinic, L. Tang, and V. Zeps
Subjects: Nuclear physics, Physics, Nuclear and High Energy Physics, chemistry, Branching fraction, Isospin, chemistry.chemical_element, Strangeness, Hypernucleus, Selectivity, Ground state, Carbon
Abstract: The (Kstopped−,π0) strangeness and charge changing reaction was investigated by producing a BΛ12 hypernucleus from a carbon target. The branching ratio for K− capture to the ground and p-shell states of this hypernucleus was found to be (0.28±0.08)×10−3 and (0.35±0.09)×10−3, respectively, which after correction for isospin was lower than a previously measured value for the C12(Kstopped−,π−)CΛ12 reaction, but still above the theoretical predictions for the ground state. The experiment obtained a missing-mass resolution comparable to in-flight reactions, however the higher background and lower selectivity of the Kstopped− reaction limits its usefulness in the study of new hypernuclear species.
Published: 2003
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28. High Resolution Spectroscopy of theΛ12BHypernucleus Produced by the(e,e′K+)Reaction

Author: C. Jackson, V.P. Likhachev, J. Roche, Miroslav Furić, R. Asaturyan, J. Cha, L. Cole, S. A. Wood, Pete Markowitz, H. Breuer, E. V. Hungerford, C. Yan, J. Martoff, K. Johnston, S. N. Nakamura, S. Wells, H. Yamaguchi, Y. Sato, D. J. Mack, P. Ambrozewicz, H. Mkrtchyan, T. Angelescu, W. F. Vulcan, T. Takahashi, I. Bertovic, W. Hinton, O. K. Baker, Stephen Avery, C. E. Keppel, L. Yuan, Tomislav Petković, M. Sarsour, A. Uzzle, H. C. Fenker, B. Hu, Y. Fujii, Darko Androić, Amur Margaryan, M. Harvey, Mifuyu Ukai, M. E. Christy, Anton Empl, R. D. Carlini, A. Ahmidouch, M. Elaasar, K. Tanida, Osamu Hashimoto, R. E. Chrien, S. Stepanyan, Guo-Lin Xu, Xiaofeng Zhu, L. Gan, G. R. Smith, Y. Liang, L. G. Tang, R. Sawafta, D. Dehnhard, Neven Simicevic, S. Danagoulian, Joerg Reinhold, H. Juengst, K. Garrow, V. Tadevosyan, T. Miyoshi, Rolf Ent, A. Gasparian, K. J. Lan, J. H. Liu, and P. Gueye
Subjects: Physics, Photon, Spectrometer, Binding energy, General Physics and Astronomy, Virtual particle, Particle accelerator, Electron, Hypernucleus, law.invention, Nuclear physics, law, Atomic physics, Spectroscopy
Abstract: High energy CW electron beams at new accelerator facilities allow electromagnetic production and precision study of hypernuclear structure, and we report here on the first experiment demonstrating the usefulness of the (e,e'K+) reaction. This experiment is also the first to take advantage of the enhanced virtual photon flux available when electrons are scattered at approximately zero degrees. The observed resolution, ~900 keV, of the 12B(hypernuclear) spectrum is the best yet attained using magnetic spectrometers. The positions of the major excitations are in agreement with theoretical predictions and the previous binding energy measurements.
Published: 2003
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29. High resolution spectroscopy of the 12Lambda B hypernucleus produced by the (e,e'K+) reaction

Author: T, Miyoshi, M, Sarsour, L, Yuan, X, Zhu, A, Ahmidouch, P, Ambrozewicz, D, Androic, T, Angelescu, R, Asaturyan, S, Avery, O K, Baker, I, Bertovic, H, Breuer, R, Carlini, J, Cha, R, Chrien, M, Christy, L, Cole, S, Danagoulian, D, Dehnhard, M, Elaasar, A, Empl, R, Ent, H, Fenker, Y, Fujii, M, Furic, L, Gan, K, Garrow, A, Gasparian, P, Gueye, M, Harvey, O, Hashimoto, W, Hinton, B, Hu, E, Hungerford, C, Jackson, K, Johnston, H, Juengst, C, Keppel, K, Lan, Y, Liang, V P, Likhachev, J H, Liu, D, Mack, A, Margaryan, P, Markowitz, J, Martoff, H, Mkrtchyan, S N, Nakamura, T, Petkovic, J, Reinhold, J, Roche, Y, Sato, R, Sawafta, N, Simicevic, G, Smith, S, Stepanyan, V, Tadevosyan, T, Takahashi, K, Tanida, L, Tang, M, Ukai, A, Uzzle, W, Vulcan, S, Wells, S, Wood, G, Xu, H, Yamaguchi, and C, Yan
Abstract: High-energy, cw electron beams at new accelerator facilities allow electromagnetic production and precision study of hypernuclear structure, and we report here on the first experiment demonstrating the potential of the (e,e'K+) reaction for hypernuclear spectroscopy. This experiment is also the first to take advantage of the enhanced virtual photon flux available when electrons are scattered at approximately zero degrees. The observed energy resolution was found to be approximately 900 keV for the (12)(Lambda)B spectrum, and is substantially better than any previous hypernuclear experiment using magnetic spectrometers. The positions of the major excitations are found to be in agreement with a theoretical prediction and with a previous binding energy measurement, but additional structure is also observed in the core excited region, underlining the future promise of this technique.
Published: 2002

30. First experiment on spectroscopy of Λ-hypernuclei by electroproduction at JLab

Author: L. Cole, J. Reinhold, L. G. Tang, R. Sawafta, A. Uzzle, J. Cha, A. Gasparian, K. Tanida, V.P. Likhachev, M. Sarsour, Miroslav Furić, Osamu Hashimoto, J. Martoff, V. Tadevosyan, M. Harvey, S. P. Wells, L. Yuan, Darko Androić, T. Angelescu, M. E. Christy, C. E. Keppel, K. J. Lan, R. D. Carlini, J. H. Liu, B. S. Hu, C. Yan, D. Dehnhard, K. Johnston, W. F. Vulcan, H. C. Fenker, H. Mkrtchyan, E. V. Hungerford, T. Takahashi, Y. Yamaguchi, C. R. Jackson, Oliver Keith Baker, R. Asaturyan, Pete Markowitz, Geoffrey Smith, Kazushige Maeda, S. Danagoulian, P. Ambrozewicz, I. Bertovic, H. Juengst, Xiaofeng Zhu, L. Gan, Anton Empl, Guo-Lin Xu, M. Elaasar, S. A. Wood, Hirokazu Tamura, R. E. Chrien, D. J. Mack, S. Stepanyan, Tomislav Petković, Stephen Avery, W. Hinton, Y. Liang, P. Gueye, A. Ahmidouch, Neven Simicevic, H. Breuer, K. Garrow, Rolf Ent, J. Roche, Toshinobu Miyoshi, Yoichi Sato, Mifuyu Ukai, Y. Fujii, and Amur Margaryan
Subjects: Physics, Particle physics, Spectrometer, Nuclear Theory, Particle accelerator, Parity (physics), Lambda, Lambda baryon, Spectral line, law.invention, Nuclear physics, law, Spin-flip, Nuclear Experiment, Spectroscopy
Abstract: The first experiment in Lambda-hypernuclear spectroscopy using the high precision electron beam at Jefferson laboratory (Jlab) has been carried out. The hypernuclear spectrometer system (HNSS) was used to measure spectra from the {sup 12}C(e, e{prime}K{sup +}){sup 12}{sub {Lambda}}B reaction with sub-1 MeV resolution, the best energy resolution obtained thus far in hypernuclear spectroscopy with magnetic spectrometers. This paper describes the HNSS and the preliminary results for the {sup 12}{sub {Lambda}}B system. The experimental spectrum is consistent with the expected strong spin-flip excitations of unnatural parity states. A program of hypernuclear physics experiments is planned for the future with much higher yield and even better energy resolution.
Published: 2001
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31. Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

Author: Ernst Tholen, Christian Looft, Mehmet Ulas Cinar, H. Juengst, Dawit Tesfaye, Muhammad Jasim Uddin, Do Ngoc Duy, and Karl Schellander
Subjects: pig, Candidate gene, Genotype, lcsh:QH426-470, Genetic Linkage, Swine, QTL, Quantitative Trait Loci, Population, Blood lipids, Enzyme-Linked Immunosorbent Assay, Quantitative trait locus, Biology, chemistry.chemical_compound, Genetics, Animals, Genetics(clinical), education, Triglycerides, Genetics (clinical), education.field_of_study, Triglyceride, Cholesterol, F2 population, Cholesterol, HDL, food and beverages, Lipid metabolism, Cholesterol, LDL, Chromosomes, Mammalian, lcsh:Genetics, Phenotype, serum lipids, chemistry, lipids (amino acids, peptides, and proteins), Microsatellite Repeats, Research Article, Blood sampling
Abstract: Background Serum lipids are associated with many serious cardiovascular diseases and obesity problems. Many quantitative trait loci (QTL) have been reported in the pig mostly for performance traits but very few for the serum lipid traits. In contrast, remarkable numbers of QTL are mapped for serum lipids in humans and mice. Therefore, the objective of this research was to investigate the chromosomal regions influencing the serum level of the total cholesterol (CT), triglyceride (TG), high density protein cholesterol (HDL) and low density protein cholesterol (LDL) in pigs. For this purpose, a total of 330 animals from a Duroc × Pietrain F2 resource population were phenotyped for serum lipids using ELISA and were genotyped by using 122 microsatellite markers covering all porcine autosomes for QTL study in QTL Express. Blood sampling was performed at approximately 175 days before slaughter of the pig. Results Most of the traits were correlated with each other and were influenced by average daily gain, slaughter date and age. A total of 18 QTL including three QTL with imprinting effect were identified on 11 different porcine autosomes. Most of the QTL reached to 5% chromosome-wide (CW) level significance including a QTL at 5% experiment-wide (GW) and a QTL at 1% GW level significance. Of these QTL four were identified for both the CT and LDL and two QTL were identified for both the TG and LDL. Moreover, three chromosomal regions were detected for the HDL/LDL ratio in this study. One QTL for HDL on SSC2 and two QTL for TG on SSC11 and 17 were detected with imprinting effect. The highly significant QTL (1% GW) was detected for LDL at 82 cM on SSC1, whereas significant QTL (5% GW) was identified for HDL/LDL on SSC1 at 87 cM. Chromosomal regions with pleiotropic effects were detected for correlated traits on SSC1, 7 and 12. Most of the QTL identified for serum lipid traits correspond with the previously reported QTL for similar traits in other mammals. Two novel QTL on SSC16 for HDL and HDL/LDL ratio and an imprinted QTL on SSS17 for TG were detected in the pig for the first time. Conclusion The newly identified QTL are potentially involved in lipid metabolism. The results of this work shed new light on the genetic background of serum lipid concentrations and these findings will be helpful to identify candidate genes in these QTL regions related to lipid metabolism and serum lipid concentrations in pigs.
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32. Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality.

Author: Kayan A, Cinar MU, Uddin MJ, Phatsara C, Wimmers K, Ponsuksili S, Tesfaye D, Looft C, Juengst H, Tholen E, and Schellander K
Subjects: Animals, Body Composition, Cooking, Gene Expression Regulation, Gene Frequency, Genetic Association Studies, Genetic Linkage, Genetic Markers, Genotype, Haplotypes, Quantitative Trait, Heritable, RNA, Messenger genetics, RNA, Messenger metabolism, Tenascin metabolism, Meat, Polymorphism, Single Nucleotide, Sus scrofa genetics, Tenascin genetics
Abstract: The research aimed to screen for polymorphism, expression of Tenascin C (TNC) and association with meat and carcass quality traits. Three single nucleotide polymorphisms were detected. In a Duroc×Pietrain F2 cross (DuPi) population, g.44488C>T was associated with meat color and ham weight; g.68794A>G was associated with pH at 24h post mortem in ham (pH24(H)) and muscle area but g.68841C>T was not statistically associated. Genotyping in a commercial Pietrain (Pi) population showed that g.44488C>T was associated with pH24(H), whereas g.68794A>G was associated with conductivity at 45 min post mortem in loin and backfat thickness. Diplotypes showed significant effects on pH24(H) in both populations. The expression was associated with pH at 45 min post mortem in loin and cooking loss. TNC was significantly higher in animals with higher muscle pH. Linkage analysis revealed four trans-regulated eQTL on four autosomes. These results suggest that TNC could be a potential candidate gene for meat quality traits in pigs., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
Published: 2011
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33. Investigation on interferon alpha-inducible protein 6 (IFI6) gene as a candidate for meat and carcass quality in pig.

Author: Kayan A, Uddin MJ, Cinar MU, Grosse-Brinkhaus C, Phatsara C, Wimmers K, Ponsuksili S, Tesfaye D, Looft C, Juengst H, Tholen E, and Schellander K
Subjects: Alleles, Animals, Cell Survival, Chromosome Mapping, Fluorescent Antibody Technique, Gene Frequency, Genotype, Polymorphism, Single Nucleotide, RNA, Messenger genetics, RNA, Messenger isolation & purification, Reverse Transcriptase Polymerase Chain Reaction, Swine, Meat analysis, Mitochondrial Proteins genetics, Muscle Proteins genetics, Muscle, Skeletal metabolism
Abstract: The aim of this research was to screen for polymorphism and to perform an association study of IFI6 with meat and carcass quality traits. A SNP (g.370A>G) was detected which was associated (P<0.05) with meat colour, pH 24h post mortem (p.m.) in ham, conductivity 45 min p.m. in loin and conductivity 24 h p.m. in ham, drip loss and carcass length in Duroc x Pietrain and with meat colour, muscle area and ham percentage in the Pietrain population. Highest expression of IFI6 mRNA was detected in skeletal muscle (longissimus dorsi) by qRT-PCR comparing different tissues. Both qRT-PCR and western blot revealed that the IFI6 gene and protein expressions were significantly (P<0.05) higher in skeletal muscle with low drip loss compared to that of high drip loss. IFI6 protein was localized in the myocytes membrane. Results suggested that IFI6 might play roles in meat and carcass quality and is a potential positional, physiological and functional candidate gene for improving meat quality traits in pigs., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
Published: 2011
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34. Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs.

Author: Uddin MJ, Duy do N, Cinar MU, Tesfaye D, Tholen E, Juengst H, Looft C, and Schellander K
Subjects: Animals, Chromosomes, Mammalian genetics, Enzyme-Linked Immunosorbent Assay, Genetic Linkage, Genotype, Microsatellite Repeats, Phenotype, Swine blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Quantitative Trait Loci, Swine genetics, Triglycerides blood
Abstract: Background: Serum lipids are associated with many serious cardiovascular diseases and obesity problems. Many quantitative trait loci (QTL) have been reported in the pig mostly for performance traits but very few for the serum lipid traits. In contrast, remarkable numbers of QTL are mapped for serum lipids in humans and mice. Therefore, the objective of this research was to investigate the chromosomal regions influencing the serum level of the total cholesterol (CT), triglyceride (TG), high density protein cholesterol (HDL) and low density protein cholesterol (LDL) in pigs. For this purpose, a total of 330 animals from a Duroc × Pietrain F2 resource population were phenotyped for serum lipids using ELISA and were genotyped by using 122 microsatellite markers covering all porcine autosomes for QTL study in QTL Express. Blood sampling was performed at approximately 175 days before slaughter of the pig., Results: Most of the traits were correlated with each other and were influenced by average daily gain, slaughter date and age. A total of 18 QTL including three QTL with imprinting effect were identified on 11 different porcine autosomes. Most of the QTL reached to 5% chromosome-wide (CW) level significance including a QTL at 5% experiment-wide (GW) and a QTL at 1% GW level significance. Of these QTL four were identified for both the CT and LDL and two QTL were identified for both the TG and LDL. Moreover, three chromosomal regions were detected for the HDL/LDL ratio in this study. One QTL for HDL on SSC2 and two QTL for TG on SSC11 and 17 were detected with imprinting effect. The highly significant QTL (1% GW) was detected for LDL at 82 cM on SSC1, whereas significant QTL (5% GW) was identified for HDL/LDL on SSC1 at 87 cM. Chromosomal regions with pleiotropic effects were detected for correlated traits on SSC1, 7 and 12. Most of the QTL identified for serum lipid traits correspond with the previously reported QTL for similar traits in other mammals. Two novel QTL on SSC16 for HDL and HDL/LDL ratio and an imprinted QTL on SSS17 for TG were detected in the pig for the first time., Conclusion: The newly identified QTL are potentially involved in lipid metabolism. The results of this work shed new light on the genetic background of serum lipid concentrations and these findings will be helpful to identify candidate genes in these QTL regions related to lipid metabolism and serum lipid concentrations in pigs.
Published: 2011
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35. Mapping quantitative trait loci for innate immune response in the pig.

Author: Uddin MJ, Cinar MU, Grosse-Brinkhaus C, Tesfaye D, Tholen E, Juengst H, Looft C, Wimmers K, Phatsara C, and Schellander K
Subjects: Animals, Cytokines blood, Genetic Markers, Models, Genetic, Phenotype, Quantitative Trait, Heritable, Toll-Like Receptors metabolism, Vaccination, Vaccines immunology, Chromosome Mapping methods, Immunity, Innate genetics, Quantitative Trait Loci genetics, Sus scrofa genetics
Abstract: The aim of the present study was to detect quantitative trait loci (QTL) for the serum levels of cytokines and Toll-like receptors as traits related to innate immunity in pig. For this purpose, serum concentration of interleukin 2 (IL2), interleukin 10 (IL10), interferon-gamma (IFNG), Toll-like receptor 2 (TLR2) and Toll-like receptor 9 (TLR9) were measured in blood samples obtained from F(2) piglets (n = 334) of a Duroc × Piétrain resource population (DUPI) after Mycoplasma hypopneumoniae (Mh), tetanus toxoid (TT) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccination at 6, 9 and 15 weeks of age. Animals were genotyped at 82 genetic markers covering all autosomes. QTL analysis was performed under the line cross F(2) model using QTL Express and 33 single QTL were detected on almost all porcine autosomes. Among the single QTL, eight, twelve and thirteen QTL were identified for innate immune traits in response to Mh, TT and PRRSV vaccine, respectively. Besides single QTL, six QTL were identified by a two-QTL model, of which two for TLR9_TT were in coupling phase and one for IL10_PRRSV was in repulsion phase. All QTL were significant at 5% chromosome-wide level including one and seven at 5% genome- and 1% chromosome-wide level significance. All innate immune traits are influenced by multiple chromosomal regions implying multiple gene action. Some of the identified QTL coincided with previously reported QTL for immune response and disease resistance, and the newly identified QTL are potentially involved in the immune function. The immune traits were also influenced by environmental factors like year of birth, age, parity and litter size. The results of this work shed new light on the genetic background of innate immune response and these findings will be helpful to identify candidate genes in these QTL regions related to immune competence and disease resistance in pigs., (© 2011 Blackwell Publishing Ltd.)
Published: 2011
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36. Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population.

Author: Laenoi W, Uddin MJ, Cinar MU, Grosse-Brinkhaus C, Tesfaye D, Jonas E, Scholz AM, Tholen E, Looft C, Wimmers K, Phatsara C, Juengst H, Sauerwein H, Mielenz M, and Schellander K
Subjects: Animals, Bone Density genetics, Breeding, Chromosome Mapping, Crosses, Genetic, Genetic Markers, Osteochondrosis genetics, Osteochondrosis pathology, Foot physiology, Muscle Weakness genetics, Quantitative Trait Loci genetics, Sus scrofa genetics
Abstract: Background: Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs., Methods: Three hundred and ten F₂ pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software., Results: Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level., Conclusions: Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
Published: 2011
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37. Mapping of quantitative trait loci for mycoplasma and tetanus antibodies and interferon-gamma in a porcine F(2) Duroc x Pietrain resource population.

Author: Uddin MJ, Grosse-Brinkhaus C, Cinar MU, Jonas E, Tesfaye D, Tholen E, Juengst H, Looft C, Ponsuksili S, Wimmers K, Phatsara C, and Schellander K
Subjects: Animals, Antibody Formation genetics, Crosses, Genetic, Genetics, Population, Phenotype, Swine immunology, Vaccination, Antibodies genetics, Chromosome Mapping methods, Interferon-gamma genetics, Mycoplasma immunology, Quantitative Trait Loci, Swine genetics, Tetanus immunology
Abstract: The aim of the present study was to detect quantitative trait loci (QTL) for innate and adaptive immunity in pigs. For this purpose, a Duroc x Pietrain F(2) resource population (DUPI) with 319 offspring was used to map QTL for the immune traits blood antibodies and interferon-gamma using 122 microsatellites covering all autosomes. Antibodies response to Mycoplasma hyopneumoniae and tetanus toxoid vaccine and the interferon-gamma (IFNG) serum concentration were measured at three different time points and were used as phenotypes. The differences of antibodies and interferon concentration between different time points were also used for the linkage mapping. Line-cross and imprinting QTL analysis, including two-QTL, were performed using QTL Express. A total of 30 QTL (12, 6, and 12 for mycoplasma, tetanus antibody, and IFNG, respectively) were identified at the 5% chromosome-wide-level significant, of which 28 were detected by line-cross and 2 by imprinting model. In addition, two QTL were identified on chromosome 5 using the two-QTL approach where both loci were in repulsion phase. Most QTL were detected on pig chromosomes 2, 5, 11, and 18. Antibodies were increased over time and immune traits were found to be affected by sex, litter size, parity, and month of birth. The results demonstrated that antibody and IFNG concentration are influenced by multiple chromosomal areas. The flanking markers of the QTL identified for IFNG on SSC5 did incorporate the position of the porcine IFNG gene. The detected QTL will allow further research in these QTL regions for candidate genes and their utilization in selection to improve the immune response and disease resistance in pig.
Published: 2010
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38. Combined line-cross and half-sib QTL analysis in Duroc-Pietrain population.

Author: Liu G, Kim JJ, Jonas E, Wimmers K, Ponsuksili S, Murani E, Phatsara C, Tholen E, Juengst H, Tesfaye D, Chen JL, and Schellander K
Subjects: Animals, Chromosomes, Mammalian genetics, Female, Genome genetics, Hydrogen-Ion Concentration, Male, Meat standards, Quantitative Trait, Heritable, Swine growth & development, Crosses, Genetic, Models, Genetic, Quantitative Trait Loci genetics, Swine classification, Swine genetics
Abstract: A Duroc-Pietrain resource population was built to detect quantitative trait loci (QTL) that affect growth, carcass composition, and pork quality. The data were analyzed by applying three least-squares Mendelian models: a line-cross (LC) model, a half-sib (HS) model, and a combined LC and HS model (CB), which enabled the detection of QTL that had fixed, equal, and different allele frequencies for alternate breed alleles, respectively. Permutation tests were performed to determine 5% chromosome-wide and 5% genome-wide threshold values. A total of 40 (137) QTL were detected at the 5% genome-wide (chromosome-wide) level for the 35 traits analyzed. Of the 137 QTL detected, 62 were classified as the LC type (LC-QTL), 47 as the HS type (HS-QTL), and 28 as the CB type (CB-QTL). The results indicate that implementation of a series of model-based framework is not only beneficial to detect QTL, but also provides us with a new and more robust interpretation from which further methodology could be developed.
Published: 2008
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39. QTL for the heritable inverted teat defect in pigs.

Author: Jonas E, Schreinemachers HJ, Kleinwächter T, Un C, Oltmanns I, Tetzlaff S, Jennen D, Tesfaye D, Ponsuksili S, Murani E, Juengst H, Tholen E, Schellander K, and Wimmers K
Subjects: Animals, Chromosomes, Mammalian genetics, Crosses, Genetic, Female, Male, Mammary Glands, Animal abnormalities, Quantitative Trait Loci genetics, Quantitative Trait, Heritable, Sus scrofa genetics
Abstract: The mothering ability of a sow largely depends on the shape and function of the mammary gland. The aim of this study was to identify QTL for the heritable inverted teat defect, a condition characterized by disturbed development of functional teats. A QTL analysis was conducted in a porcine experimental population based on Duroc and Berlin Miniature pigs (DUMI). The significant QTL were confirmed by linkage analysis in commercial pigs according to the affected sib pair design and refined by family-based association test (FBAT). Nonparametric linkage (NPL) analysis revealed five significant and seven suggestive QTL for the inverted teat defect in the porcine experimental population. In commercial dam lines five significant NPL values were detected. QTL regions in overlapping marker intervals or close proximity in both populations were found on SSC3, SSC4, SSC6, and SSC11. SSC6 revealed QTL in both populations at different positions, indicating the segregation of at least two QTL. The results confirm the previously proposed polygenic inheritance of the inverted teat defect and, for the first time, point to genomic regions harboring relevant genes. The investigation revealed variation of the importance of QTL in the various populations due to either differences in allele frequencies and statistical power or differences in the genetic background that modulates the impact of the liability loci on the expression of the disease. The QTL study enabled us to name a number of plausible positional candidate genes. The correspondence of QTL regions for the inverted teat defect and previously mapped QTL for teat number are in line with the etiologic relationship of these traits.
Published: 2008
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40. Verification of chromosomal regions affecting the innate immunity in pigs using linkage mapping.

Author: Wimmers K, Jonas E, Schreinemachers HJ, Tesfaye D, Ponsuksili S, Tholen E, Juengst H, Schellander K, and Phatsara C
Subjects: Animals, Antibodies, Bacterial biosynthesis, Complement System Proteins genetics, Mycoplasma hyopneumoniae immunology, Quantitative Trait Loci, Chromosome Mapping veterinary, Genetic Linkage, Immunity, Innate genetics
Abstract: Understanding the genetic control of innate immunity in pigswould offerthe opportunity to utilize natural variation and improve selective breeding programmes. As part of our porcine genome scan to identify quantitative trait loci (QTL) we examined immune response traits in a Duroc x Berlin miniature pig resource family (DUMI). Complement activity via classical (CH50) and alternative (AH50) pathways, antibody response to Mycoplasma hyopneumoniae (Mh), tetanus toxoid (TET) and PRRS virus (PRRSV), the complement component (C3c), and Haptoglobin serum concentration (HP) were used as phenotypes for linkage mapping. A total of 220 backcross animals were used for the QTL analysis. Blood was collected six times from each animal prior to and after vaccinations against Mycoplasma hyopneumoniae, tetanus toxoid and PRRS, respectively. Seventy-four microsatellites from 18 autosomes were used for QTL mapping. The analyses were performed treating the measurements of phenotypes at different time points as single traits. Forty-two significant and 24 highly significant QTL were detected, using the program QTL Express, for all immune traits using the single traits. Most QTL were detected on SSC3, SSC16, and SSC18. No significant F-value corresponded to data for SSC12 and SSC13.
Published: 2008
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41. Physiological interactions between the endocrine and immune systems shown in gene analysis in pigs.

Author: Phatsara C, Jonas E, Yammuen-Art S, Buschbell H, Tesfaye D, Ponsuksili S, Tholen E, Juengst H, Schellander K, and Wimmers K
Subjects: Alleles, Animals, Gene Frequency, Genotype, Polymorphism, Single Nucleotide, Swine genetics, Endocrine Glands physiology, Immune System physiology, Swine physiology
Abstract: A number of observations support the concept of important physiological interactions between the endocrine and immune systems. It could be confirmed that hormones secreted by the neuroendocrine system play an important role in communication and regulation of the cells of the immune system. Among protein hormones, this has been most clearly documented for prolactin (PRL), growth hormone (GH), and insulin-like growth factor 1 (IGF-1). A number of traits of the immune response in a Duroc x Berlin Miniature pig family (DUMI) were examined. The haemolytic complement activity in the classical complement pathway (CH50) and the alternative pathway (AH50)was examined at eight different time points in pigs that were vaccinated with different vaccines. Single nucleotide polymorphism (SNP) genotyping was employed to genotype the DUMI F2 animal for growth hormone (Gh), growth hormone releasing hormone (Ghrh), pituitary-specific transcription factor 1 (Pit1), and prolactin receptor (Prlr) loci, and also a microsatellite within insulin-like growth factor 1 (Igf1). Using a family-based association test (FBAT) program, a highly significant association of Gh, Pit1, and Prlr to AH50 (p < or = 0.01) and a significant association of Pit1 to CH50 (p < or = 0.05) were found. Using the SAS system for mixed model, a highly significant association of Gh, and Igf1 to AH50 and CH50 (p < or = 0.01) was detected, while Prlr and Ghrh had a highly significant association (p < or = 0.01) with CH50 only.
Published: 2008
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42. A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population.

Author: Liu G, Jennen DG, Tholen E, Juengst H, Kleinwächter T, Hölker M, Tesfaye D, Un G, Schreinemachers HJ, Murani E, Ponsuksili S, Kim JJ, Schellander K, and Wimmers K
Subjects: Animals, Body Composition, Breeding, Chromosome Mapping, Crosses, Genetic, Genomics methods, Microsatellite Repeats genetics, Sus scrofa growth & development, Meat, Phenotype, Quantitative Trait Loci, Sus scrofa genetics
Abstract: We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.
Published: 2007
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43. Angular distributions for (3,4)(Lambda)H bound states in the (3,4)He(e,e(')K+) reaction.

Author: Dohrmann F, Ahmidouch A, Armstrong CS, Arrington J, Asaturyan R, Avery S, Bailey K, Bitao H, Breuer H, Brown DS, Carlini R, Cha J, Chant N, Christy E, Cochran A, Cole L, Crowder J, Danagoulian S, Elaasar M, Ent R, Fenker H, Fujii Y, Gan L, Garrow K, Geesaman DF, Gueye P, Hafidi K, Hinton W, Juengst H, Keppel C, Liang Y, Liu JH, Lung A, Mack D, Markowitz P, Mitchell J, Miyoshi T, Mkrtchyan H, Mtingwa SK, Mueller B, Niculescu G, Niculescu I, Potterveld D, Raue BA, Reimer PE, Reinhold J, Roche J, Sarsour M, Sato Y, Segel RE, Semenov A, Stepanyan S, Tadevosian V, Tajima S, Tang L, Uzzle A, Wood S, Yamaguchi H, Yan C, Yuan L, Zeidman B, Zeier M, and Zihlmann B
Abstract: The (3,4)(Lambda)H and (4)(Lambda)H hypernuclear bound states have been observed for the first time in kaon electroproduction on (3,4)He targets. The production cross sections have been determined at Q(2)=0.35 GeV2 and W=1.91 GeV. For either hypernucleus the nuclear form factor is determined by comparing the angular distribution of the (3,4)He(e,e(')K+)(3,4)(Lambda)H processes to the elementary cross section 1H(e,e K+)Lambda on the free proton, measured during the same experiment.
Published: 2004
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44. High resolution spectroscopy of the 12Lambda B hypernucleus produced by the (e,e'K+) reaction.

Author: Miyoshi T, Sarsour M, Yuan L, Zhu X, Ahmidouch A, Ambrozewicz P, Androic D, Angelescu T, Asaturyan R, Avery S, Baker OK, Bertovic I, Breuer H, Carlini R, Cha J, Chrien R, Christy M, Cole L, Danagoulian S, Dehnhard D, Elaasar M, Empl A, Ent R, Fenker H, Fujii Y, Furic M, Gan L, Garrow K, Gasparian A, Gueye P, Harvey M, Hashimoto O, Hinton W, Hu B, Hungerford E, Jackson C, Johnston K, Juengst H, Keppel C, Lan K, Liang Y, Likhachev VP, Liu JH, Mack D, Margaryan A, Markowitz P, Martoff J, Mkrtchyan H, Nakamura SN, Petkovic T, Reinhold J, Roche J, Sato Y, Sawafta R, Simicevic N, Smith G, Stepanyan S, Tadevosyan V, Takahashi T, Tanida K, Tang L, Ukai M, Uzzle A, Vulcan W, Wells S, Wood S, Xu G, Yamaguchi H, and Yan C
Abstract: High-energy, cw electron beams at new accelerator facilities allow electromagnetic production and precision study of hypernuclear structure, and we report here on the first experiment demonstrating the potential of the (e,e'K+) reaction for hypernuclear spectroscopy. This experiment is also the first to take advantage of the enhanced virtual photon flux available when electrons are scattered at approximately zero degrees. The observed energy resolution was found to be approximately 900 keV for the (12)(Lambda)B spectrum, and is substantially better than any previous hypernuclear experiment using magnetic spectrometers. The positions of the major excitations are found to be in agreement with a theoretical prediction and with a previous binding energy measurement, but additional structure is also observed in the core excited region, underlining the future promise of this technique.
Published: 2003
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