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Your search keyword '"H. J., Pramod"' showing total 3 results
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3 results on '"H. J., Pramod"'

1. Mitral Annular Disjunction with bileaflet mitral valve prolapse.

Author

J., Bhagyashree, Bhat, Anand Subraya, H. J., Pramod, N. C., Chandana, B., Girish, and K. S., Ravindranath

Subjects
MITRAL valve, MITRAL valve insufficiency, CARDIAC arrest, VENTRICULAR fibrillation, ARRHYTHMIA, MITRAL valve prolapse
Abstract

Mitral annular disjunction (MAD) is a structural abnormality of the mitral valve whereby there is a distinct separation of the mitral valve annulus-left atrial wall continuum and the basal portion of the posterolateral ventricular myocardium, a region which would normally be attached. It is usually associated with myxomatous mitral valve disease. MAD has been reported in various studies since the last four decades as constituting around 42-90% of patients with myxomatous mitral valve disease and mitral valve prolapse. It is often associated with arrhythmias ranging from benign ventricular ectopics to malignant ventricular fibrillations causing sudden cardiac deaths in the young. This condition seems to be more common in women. Last few decades have witnessed many case reports and prospective studies about this entity enhancing our understanding about its pathophysiology. We report a case of a 34 year old male with mitral valve prolapse and MAD resulting in severe mitral regurgitation who underwent mitral valve replacement. [ABSTRACT FROM AUTHOR]

Published
2024

2. FORMULATION OF ATOVAQUONE TABLET USING BIOSURFACTANT IN A TERNARY SOLID DISPERSION SYSTEM: IN VITRO AND IN VIVO EVALUATION

Author

Udaykumar B. Bolmal and H J Pramod

Subjects
Chromatography, Ternary numeral system, Chemistry, Pharmaceutical Science, Dosage form, Bioavailability, chemistry.chemical_compound, In vivo, Methyl cellulose, medicine, Solubility, Ternary operation, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Atovaquone, medicine.drug
Abstract

Objective: The goal of the present investigation was to improve the solubility and bioavailability of atovaquone tablet, using in-house biosynthesized biosurfactant in the ternary system of solid dispersion containing hydrophilic polymers with varying concentrations of biosurfactant. Atovaquone is an anti-malarial agent and belongs to biopharmaceutical classification system class IV. Methods: The solid dispersion of binary and ternary mixture was prepared using hydroxyl propyl methyl cellulose (HPMC) and biosurfactant respectively by a solvent evaporation method. All the atovaquone tablet formulations were prepared by incorporation of physical mixture, binary and ternary solid dispersed products with excipients by direct compression method. Pre-compression and post-compression parameters of atovaquone tablets were evaluated. In vivo bioavailability study was performed using female albino rabbits. Results: In vitro dissolution profile of binary and ternary system of solid dispersion products showed 8.65% and 34.64% respectively. Precompression and post-compression values of all atovaquone tablets formulations were within the specified limits. In vitro dissolution efficiency of F2 and F5 were 1.44 fold and 6.62 fold respectively, in accordance to the F1. In vivo study revealed that bioavailability of optimized formulation F5 was increased by 2.5 times and time to reach peak concentration was reduced to 1.4 h, in accordance to pure atovaquone suspension. Conclusion: Potential application of biosurfactant in the solid dosage form of atovaquone tablet was proved for enhanced dissolution rate and bioavailability of atovaquone for malaria treatment.

Published
2019

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