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1. Acute Rejection After Swine Leukocyte Antigen-Matched Kidney Allo-Transplantation in Cloned Miniature Pigs With Different Mitochondrial DNA-Encoded Minor Histocompatibility Antigen

Author

Pankaj Kumar Teotia, H.-H. Kwak, Kyung-Mee Park, Heung-Myong Woo, C. Ahn, G.-S. Lee, S.-H. Hong, S.-M. Park, E.-S. Lee, Kyung-Woo Lee, Chankyu Park, and S.-R. Yang

Subjects
Graft Rejection, Transplantation, Base Sequence, Swine, Histocompatibility Testing, Immunogenicity, fungi, Human leukocyte antigen, Biology, DNA, Mitochondrial, Kidney Transplantation, Polymerase Chain Reaction, Histocompatibility, Minor Histocompatibility Antigens, Mononuclear cell infiltration, Immune system, Antigen, Immunology, Minor histocompatibility antigen, Animals, Swine, Miniature, Surgery, DNA Primers
Abstract

Introduction Graft rejection remains a major cause of morbidity and mortality following renal transplantation. One of the main determinants of success after renal transplantation is histocompatibility between donor and recipient. Most of the research on this topic has addressed human leukocyte antigen (HLA), but the roles played by minor histocompatibility antigens (mHAgs), such as mitochondrially transmitted antigens, are poorly understood. In this study, we evaluated immune responses induced by minor antigens originating from mitochondrial DNA (mtDNA) in a large animal model. Methods To characterize whole swine leukocyte antigen (SLA) allele in 8 cloned pigs, we performed SLA genotyping for SLA-1, SLA-2, SLA-3, SLA-DQB1, and SLA-DRB1 as well as the hypervariable region 1 (HV1) of mtDNA. Renal transplantation was performed using SLA-matched pigs with different mtDNA as well as SLA-mismatched cloned animals. Cytokine profiling was performed by incubating peripheral leukocytes with cellular components from SLA-matched different mtDNA and SLA-mismatched cells to evaluate mtDNA-mediated immune response. Results SLA types were confirmed to be identical, but mtDNA sequences of HV1 varied among cloned pigs. Rejection episodes in the SLA-matched group with different mtDNA were similar to those in the SLA-mismatched group; that is, plasma creatinine and BUN levels were increased and mononuclear cell infiltration was observed in perivascular regions in the matched and SLA-mismatched groups. Furthermore, in vitro studies showed interleukin (IL)-1β expression to be elevated in SLA-matched and SLA-mismatched groups. Conclusion Cloned pigs are a useful preclinical model to evaluate the immunogenicity of mtDNA encoding minor antigens. The mtDNA originating from nongenomic DNA induced cell-mediated immune rejection after kidney transplantation.

Published
2013

2. Platform session

Author

G. Feigl, W. Rosmarin, B. Weninger, R. Likar, P. V. Hoogland, R. J. M. Groen, W. Vorster, M. Grobbelaar, C. J. F. Muller, D. F. du Toit, B. Moriggl, M. Greher, A. Klauser, U. Eichenberger, J. M. Prades, A. Timoshenko, M. Faye, C. H. Martin, M. Baroncini, H. Baiz, A. Ben Henda, C. Fontaine, G. Baksa, M. Toth, L. Patonay, A. Gonçalves-Ferreira, C. Gonçalves, L. Neto, T. Fonseca, H. Gaspar, J. Rino, M. Fernandes, P. Fernandes, H. Cardoso, B. Miranda, J. Rego, A. Hamel, P. Guillouche, O. Hamel, M. Garçon, S. Lager, Y. Blin, O. Armstrong, R. Robert, J. M. Rogez, J. Le Borgne, G. Kahilogulları, A. Comert, A. F. Esmer, E. Tuccar, I. Tekdemir, M. Ozdemir, A. B. Odabasi, A. Elhan, M. K. Anand, P. R. Singh, M. Verma, C. J. Raibagkar, H. J. Kim, H. H. Kwak, K. S. Hu, J. P. Francke, V. Macchi, A. Porzionato, A. Parenti, P. Metalli, G. F. Zanon, R. De Caro, A. Bernardes, J. Dionísio, P. Messias, J. Patrício, N. Apaydin, A. Uz, O. Evirgen, K. S. Shim, H. D. Park, K. H. Youn, M. Cajozzo, T. Bartolotta, F. Cappello, A. Sunseri, M. Romeo, G. Altieri, G. Modica, G. La Barbera, G. La Marca, F. Valentino, B. Valentino, A. Martino, G. Dees, W. A. Kleintjes, R. Williams, B. Herpe, J. Leborgne, S. Lagier, A. Cordova, R. Pirrello, F. Moschella, M. V. Mahajan, U. B. Bhat, S. V. Abhayankar, M. V. Ambiye, D. K. Kachlík, J. S. Stingl, B. S. Sosna, P. F. Fára, A. L. Lametschwandtner, B. M. Minnich, Z. S. Straka, M. Ifrim, C. Feng Ifrim, M. Botea, R. Latorre, F. Sun, R. Henry, V. Crisóstomo, F. Gil Cano, J. Usón, F. Mtez-Gomaríz, S. Climent, V. Hurmusiadis, S. Barrick, J. Barrow, N. Clifford, F. Morgan, R. Wilson, L. Wiseman, O. A. Fogg, M. Loukas, R. A. Tedman, N. Capaccioli, L. Capaccioli, A. Mannini, G. Guazzi, M. Mangoni, F. Paternostro, P. Terrosi Vagnoli, M. Gulisano, S. Pacini, B. Grignon, R. Jankowski, D. Hennion, X. Zhu, J. Roland, G. Mutiu, V. Tessitore, M. L. Uzzo, G. Bonaventura, G. Milio, G. F. Spatola, T. Ilkan, T. Selcuk, A. M. Mustafa, C. H. Hamdi, T. C. Emel, U. Faruk, G. Bulent, V. Báča, A. Doubková, D. Kachlík, J. Stingl, C. Saylam, Ö. Kitiş, H. Üçerler, E. Manisahı, A. S. Gönül, G. H. R. Dashti, M. Nematbaksh, M. Mardani, J. Hami, M. Rezaian, B. Radmehr, M. Akbari, M. R. Paryani, H. Gilanpour, C. Zamfir, M. Zamfir, C. Lupusoru, C. Raileanu, R. Lupusoru, P. Bordei, D. Iliescu, E. Şapte, S. Adam, C. Baker, C. Sergi, F. Barberini, M. Ripani, V. Di Nitto, A. Zani, F. Magnosi, R. Heyn, G. Familiari, U. Elgin, D. Demiryurek, N. Berker, B. Ilhan, T. Simsek, A. Batman, A. Bayramoglu, Q. A. Fogg, A. Bartczak, M. Kamionek, M. Kiedrowski, M. Fudalej, T. Wagner, W. Artibani, C. Tiengo, G. Taglialavoro, F. Mazzoleni, R. Scapinelli, E. Ardizzone, V. Cannella, D. Peri, R. Pirrone, and G. Peri

Subjects
Multimedia, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Surgery, Session (computer science), Anatomy, business, computer.software_genre, computer, Pathology and Forensic Medicine
Published
2005

3. Poster presentation

Author

F. Duparc, M. Noyon, J. Ozeel, A. Gerometta, C. Michot, M. Tadjalli, H. Moslemy, S. Safaei, A. Heiman, S. Wish-Baratz, T. Melnikov, E. Smoliar, A. Y. Hakan, F. Yucel, D. K. Kachlík, M. P. Pešl, V. B. Báča, J. S. Stingl, K. D. Kachlík, Č. P. Čech, B. V. Báča, B. Mompeó, A. Marrero-Rodriguez, A. Zeybek, B. Sağlam, E. Çikler, Ş. Çetinel, F. Ercan, G. Şener, Y. Kawawa, E. Kohda, T. Tatsuya, M. Moroi, T. Kunimasa, M. Nagamoto, H. Terada, B. C. J. Labuschagne, T. J. van der Krieke, P. V. Hoogland, C. J. F. Muller, R. Lyners, W. Vorster, P. Matusz, D. E. Zaboi, S. C. Xu, L. L. Tu, Q. Wang, M. Zhang, H. Han, W. Tao, Y. Jiao, G. Pang, M. E. Aydin, C. Kopuz, M. T. Demir, M. Yildirim, A. Kale, Y. Ince, K. Khamanarong, P. Jeeravipoolvarn, W. Chaijaroonkhanarak, W. Gawgleun, T. Fujino, A. Uz, N. Apaydin, M. Bozkurt, A. Elhan, M. T. Sheibani, M. Adibmoradi, N. Jahovic, I. Alican, G. Erkanli, S. Arbak, S. Karakaş, F. Taşer, H. Güneş, Y. Yildiz, Y. Yazici, R. C. Aland, V. Kippers, W. C. Song, S. H. Park, C. Shin, K. S. Koh, G. Russo, F. Pomara, M. Veca, F. Cacciola, U. Martorana, G. Gravante, A. C. Tobenas-Dujardin, A. Laquerrière, J. M. Muller, P. Fréger, N. López-Serna, E. Álvarez-González, V. Torres-Gonzàlez, G. Laredo-López, G. V. Esparza-González, R. Álvarez-Cantú, C. E. Garza-González, S. Guzmán-López, M. M. Aldur, H. H. Çelik, S. Sürücü, C. Denk, H. J. Yang, Y. C. Gil, T. J. Kim, H. Y. Lee, W. J. Lee, H. Lee, K. S. Hu, K. Akita, H. J. Kim, H. S. Jung, H. Gurbuz, S. Balik, G. Wavreille, C. Chantelot, X. Demondion, C. Fontaine, S. Çavdar, A. Yalin, E. Saka, Ö. Özdoǧmuş, Ö. Çakmak, L. Elevli, B. Saǧlam, D. Coquerel-Beghin, P. Y. Milliez, G. Lemierre, G. Oktem, S. Vatansever, S. Ayla, A. Uysal, S. Aktas, B. Karabulut, A. Bilir, S. Uslu, H. Aktug, M. E. Yurtseven, H. H. Celik, I. Tatar, S. Surucu, A. Karaduman, S. Tunali, S. Neuhüttler, A. Kröll, B. Moriggl, E. Brenner, M. Loukas, S. Arora, R. G. Louis, Q. A. Fogg, T. Wagner, R. A. Tedman, H. Y. Ching, N. Eze, I. D. Bottrill, P. Blyth, R. L. M. Faull, J. Vuletic, R. E. Elizondo-Omaña, M. A. García Rodríguez, S. Guzmán López, O. Tijerina de la Garza, Y. H. Liu, K. L. Zhang, D. H. Lu, H. H. Kwak, H. D. Park, K. H. Youn, H. J. Kang, H. C. Kang, S. H. Han, Z. A. Aktan Ikiz, H. Ucerler, M. Uygur, T. Kutoglu, C. Dina, D. Iliescu, E. Şapte, P. Bordei, I. Lekšan, M. Marcikić, R. Radić, V. Nikolić, S. Kurbel, R. Selthofer, V. Báča, A. Doubková, D. Kachlík, J. Stingl, V. Džupa, R. Grill, Y. S. Nam, D. J. Paik, C. S. Shin, S. J. Kim, D. G. Kim, C. S. Jin, D. I. Kim, U. Y. Lee, D. S. Kwak, J. H. Lee, C. H. Han, A. Carpino, V. Rago, F. Romeo, C. Carani, S. Andò, R. Y. Arican, N. Coskun, L. Sarikcioglu, M. Sindel, Y. R. Arican, U. Altun, U. Ozsoy, N. Oguz, F. B. Yildirim, K. Nakajima, E. Duygulu, H. Aydin, E. Inanc Gurer, O. Ozkan, S. Tuzuner, U. Özsoy, S. Çubukçu, B. M. Demirel, S. M. Akkin, T. Marur, A. H. Weiglein, T. T. Maghiar, C. Borza, A. Bumbu, G. Bumbu, G. Polle, I. Auquit-Auckbur, F. Dujardin, N. Biga, E. Olivier, T. Defives, S. Ghazali, G. Anastasi, G. Rizzo, A. Favaloro, D. Miliardi, O. Giacobbe, G. Santoro, F. Trimarchi, G. Cutroneo, F. Govsa, O. Bilge, M. A. Ozer, S. Erdogmus, F. Grizzi, F. Pelillo, M. Mori, B. Franceschini, N. Portinaro, G. Godlewski, M. Viala, J. P. Rouanet, D. Prat, Z. S. Rahmé, M. Prudhomme, E. Eken, M. Kwiatkowska, J. Liegmann, R. Chmielewski, J. Grimmond, M. Kwiatkowski, M. V. Schintler, G. Windisch, G. Wittgruber, E. C. Prandl, P. Prodinger, F. Anderhuber, E. Scharnagl, A. Gerbino, M. Buscemi, A. Leone, R. Mandracchia, G. Peri, D. Lipari, E. Farina-Lipari, B. Valentino, S. D’Arpa, A. Cordova, F. Bucchieri, A. Ribbene, S. David, A. Palma, D. E. Davies, H. M. Haitchi, S. T. Holgate, G. La Rocca, R. Anzalone, C. Campanella, F. Rappa, T. Bartolotta, F. Cappello, M. Bellafiore, G. Sivverini, D. Palumbo, F. Macaluso, F. Farina, V. Di Felice, A. Montalbano, N. Ardizzone, V. Marcianò, G. Zummo, E. Tanyeli, M. Üzel, F. Carini, G. A. Scardina, P. Varia, V. Valenza, P. Messina, J. H. Meiring, C. Schumann, I. Whitmore, L. M. Greyling, O. Hamel, A. Hamel, R. Robert, M. Garçon, S. Lagier, Y. Blin, O. Armstrong, J. M. Rogez, J. Le Borgne, C. Feng Ifrim, A. Maghiar, M. Botea, M. Ifrim, O. Pop, M. Sandor, Z. Behdadipour, M. Saberi, E. Esfandiary, C. Gentile, A. Marconi, M. A. Livrea, G. Uzan, P. D’Alessio, C. G. Ridola, N. Grassi, G. Pantuso, A. Bottino, E. Cacace, S. Li Petri, F. Di Gaudio, G. Guercio, M. A. Latteri, D. Nobile, C. Cipolla, G. Caruso, G. Salvaggio, A. Lo Cascio, G. Fatta, R. Lagalla, A. Campisi, F. Verderame, A. Martegani, A. E. Cardinale, and M. V. Luedinghausen

Subjects
Radiology, Nuclear Medicine and imaging, Surgery, Anatomy, Pathology and Forensic Medicine
Published
2005

9. The discomallear ligament and the anterior ligament of malleus: An anatomic study in human adults and fetuses.

Author

H. J. Kim, H. S. Jung, H. H. Kwak, K. S. Shim, K. S. Hu, H. D. Park, H. W. Park, and I. H. Chung

Subjects
HYPERTENSION, LIGAMENTS, MIDDLE ear diseases, TYMPANIC membrane
Abstract

According to some reports, movement of the malleus, resulting from anterior hypertension on the discomallear ligament (DML), could produce aural symptoms related with damage to middle ear structures. The aim of this study was to examine the topographic relationship of the DML and the anterior ligament of malleus (ALM). Four fetuses and 16 adult hemi-sectioned heads were used to determine the anatomic-clinical relevance of DML and ALM in temporomandibular disorder. In fetal specimens, the DML was distinctly interposed between the malleus and the disc of the temporomandibular joint (TMJ), and the ALM had a structure apparently composed of the superior and inferior lamellae, running anteriorly in continuation with the sphenomandibular ligament (SML) through the future petrotympanic fissure (PTF). In all adult specimens, the DML was inserted into the malleus, and it expanded broadly toward the disc and capsular region of the TMJ in a triangular shape and inserted into the disc and capsule of the TMJ. The two-lamellae structure of the ALM was not distinguishable in adult specimens. The overstretched ALM resulted in movement of the malleus in five cases, but similar tension applied to the DML did not cause any movement of the malleus. This result provides an indication of the clinical significance of the ALM, a ligamentous structure continuous with the SML. It is apparent that the ALM has the potential to cause aural symptoms as a result of damage to the middle ear structure. [ABSTRACT FROM AUTHOR]

Published
2004
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11. Vagotomy and gastric drainage for peptic ulcer

Author

R Z, Pierpont, W K, Brendle, D T, Crawford, H H, Kwak, and M C, Abellana

Subjects
Adult, Male, Peptic Ulcer, Adolescent, Drainage, Humans, Female, Middle Aged, Vagotomy, Child, Gastroenterostomy, Aged
Published
1966

12. First-principles study of confinement effects on the Raman spectra of Si nanocrystals.

Author

Khoo KH, Zayak AT, Kwak H, and Chelikowsky JR

Abstract

The Raman spectra of Si nanocrystals are studied as a function of nanocrystal diameter using pseudopotential density functional theory and the Placzek approximation. Our calculations reproduce the redshift and broadening of the optical Raman peak with decreasing nanocrystal size, and calculated peak frequencies show good agreement with experimental values. We also find that a surface induced softening of vibrational modes is largely responsible for the Raman redshift, with relaxation of momentum conservation playing only a minor role.

Published
2010
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13. Duodenal polypectomy is a rare cause of acute pancreatitis.

Author

Kwak H, Darmas B, and Nutt M

Subjects
Biopsy, Drainage, Fatal Outcome, Humans, Male, Middle Aged, Multiple Organ Failure etiology, Pancreatitis, Acute Necrotizing diagnostic imaging, Tomography, X-Ray Computed, Duodenal Diseases surgery, Duodenoscopy adverse effects, Intestinal Polyps surgery, Pancreatitis, Acute Necrotizing etiology
Abstract

Endoscopic duodenal polypectomy is a routine procedure particularly useful for obtaining histological diagnosis but it is not without serious complications. This is a case report of severe necrotising pancreatitis after duodenal polypectomy. We suggest that experienced endoscopists should carry out polypectomies and that clear guidelines for the management of duodenal polyps are required. Patients undergoing endoscopic duodenal polypectomies should be placed at the beginning of the endoscopy list and observed for at least 4 h.

Published
2009
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14. Arginine-genotype interactions and immune status.

Author

Kwak H, Austic RE, and Dietert RR

Abstract

The effects of arginine on selective immune responses were investigated in a high arginine-requiring (HA) and low arginine-requiring (LA) strain of chickens. Female chickens from these strains were fed diet containing a nutritionally inadequate level of arginine (0.53% arginine diet) or a surfeit level of arginine (1.53% arginine diet) for 2 weeks. Compared to LA chickens, HA chickens showed a higher feed efficiency, body weight gain, and relative thymus and spleen weights with L-arginine supplementation (p < 0.05). In both HA and LA chickens, a deficiency of arginine significantly decreased the delayed-type hypersensitivity response (p < 0.05) and nitric oxide (NO) production from macrophages. Chickens of the HA strain had higher NO production than those of LA strain with E. coli lipopolysaccharide (LPS) activation. This study indicates that dietary arginine concentration influences the immune status of chickens and that strains that differ in arginine requirements for growth may differ in their arginine needs for immune function.

Published
2001
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15. Effects of cartap on the early-life stages of medaka (Oryzias latipes).

Author

Kwak H, Bae M, Lee M, Sung H, Shin J, Ahn G, Kim Y, Lee C, and Cho M

Subjects
Aging physiology, Animals, Embryo, Nonmammalian drug effects, Female, Growth drug effects, Larva, Male, No-Observed-Adverse-Effect Level, Survival Analysis, Teratogens toxicity, Antinematodal Agents toxicity, Oryzias growth & development, Oryzias physiology, Thiocarbamates toxicity
Published
2000
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16. Mutagenicity of recombinant antihemophilic factor (GC-gamma AHF).

Author

Shin M, Kim B, Mar W, Fang M, Son J, Kim M, Kwak H, Bae M, Byun T, Park S, Chun B, Byun J, An G, Lee B, and Cho M

Subjects
Animals, Chromosome Aberrations, Cricetinae, Cricetulus, Factor VIII administration & dosage, Fibroblasts, Humans, Injections, Intraperitoneal, Lung cytology, Male, Mice, Mice, Inbred ICR, Micronucleus Tests, Mutagenicity Tests, Recombinant Proteins administration & dosage, Recombinant Proteins toxicity, Salmonella typhimurium drug effects, Salmonella typhimurium genetics, Subcellular Fractions drug effects, Tetrazolium Salts, Thiazoles, Factor VIII toxicity, Mutagens toxicity
Abstract

This study was carried out to evaluate the mutagenic potential of recombinant antihemophilic factor VIII (GC-gamma AHF). Salmonella typhimurium (S. typhimurium) reversion assay with/without histidine moiety, chromosomal aberration assay on Chinese hamster lung (CHL) fibroblast cells and in vivo micronucleus assay using mouse bone marrow cells and supravital micronucleus assay using peripheral blood were performed. GC-gamma AHF containing histidine did show inconsistent and irregular mutagenic effects on S. typhimurium TA98, TA100, TA1535 and TA1537 both in the absence and presence of the metabolic activation system, however, GC-gamma AHF without histidine showed no mutagenic effects regardless of the metabolic activation system, thus suggesting that the histidine moiety in GC-gamma AHF might cause inconsistent mutagenic effect. Also GC-gamma AHF did not increase the number of cells having structural or numerical chromosome aberration in the cytogenetic test. In classical and supravital micronucleus assay, no significant increases were observed in the occurrence of micronucleated polychromatic erythrocytes and micronucleated peripheral lymphocytes in male ICR mice. These results strongly indicate that GC-gamma AHF has no genetic toxicity under these experimental conditions.

Published
2000
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17. Influence of dietary arginine concentration on lymphoid organ growth in chickens.

Author

Kwak H, Austic RE, and Dietert RR

Subjects
Amino Acids blood, Animals, Body Weight, Bursa of Fabricius growth & development, Chickens growth & development, Dietary Supplements, Female, Organ Size, Spleen growth & development, Thymus Gland growth & development, Arginine administration & dosage, Chickens immunology, Diet, Lymphoid Tissue growth & development
Abstract

In vivo effects of graded dietary levels of arginine on the body and lymphoid organs were investigated using Cornell K strain chickens of the B15/B15 haplotype. Two-week-old birds were fed an arginine-deficient basal diet (0.53% arginine) supplemented with additional arginine (up to 1.0% L-arginine to the diet). At four weeks of age, body weight, lymphoid organ weight, and concentrations of amino acids in plasma were measured. Arginine supplementation produced significant increases in plasma arginine (from 200 nM in chicks fed the basal diet to 2,000 nM in chicks receiving the 1.5% arginine diet) and ornithine concentrations (from 17 nM in chicks fed the basal diet to 500 nM in chicks receiving the 1.5% arginine diet). The arginine-deficient diet reduced body weight gain (P < 0.0001) and thymus, spleen, and bursa of Fabricius weights (P < 0.05). In contrast to the bursa weight, the thymus and spleen weights, as percentages of body weight, were also decreased (P < 0.05). This study suggests that arginine markedly influences lymphoid organ development, with a more pronounced effect on the thymus and spleen than on the bursa of Fabricius.

Published
1999
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