Search

Observation of high energy and very high emission from Gamma Ray Bursts (GRBs) is crucial to study the gigantic explosion and the underline processes. With a large field-of-view and almost full duty cycle, the Water Cherenkov Detector Array (WCDA), a sub-array of the Large High Altitude Air Shower Observatory (LHAASO), is appropriate to monitor the very high energy emission from unpredictable transients such as GRBs. Nevertheless, the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the detector. To address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRB observation. The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRB direction at 10-300 GeV. The sensitivity of the WCDA for GRB detection with the new trigger method is estimated. The achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of Fermi-LAT. The data analysis process and corresponding fluence upper limit for GRB 190719C is presented as an example.

The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 TeV. To observe high-energy shower events, especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV, a dynamic range extension system (WCDA++) is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in WCDA-1. The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events, which is an important parameter for identifying the composition of primary particles. The system has been running for more than one year. In this paper, the details of the design and performance of WCDA++ are presented.

The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 105 and 109 GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.

IntroductionPoverty has a detrimental influence on psychological well-being of children. Existing evidence shows that positive psychology interventions are possible to mitigate such impact. Despite criticisms that positive psychology resembles a scientific Pollyannaism that promotes overly positivity, positive psychology is not the scientific Pollyannaism that denies the difficulties and emotions that people may experience. Whereas, positive psychology acknowledges the difficulties and emotions, alongside with building up human resilience, strength and growth to face adversity. This study examined the feasibility of implementing a positive psychology intervention among Hong Kong Chinese children living in poverty.MethodsA feasibility randomised controlled trial will be conducted. A convenience sample of 120 children aged 13–17 years will be recruited from a community centre in Kwai Tsing district. Participants who are randomised into the experimental group will join a 1.5-hour workshop covering four positive psychology techniques: (1) gratitude visits/letters, (2) three good things, (3) you at your best and (4) using signature strengths. A booster intervention will be provided at 1 week. Control group participants will not receive any intervention. Assessments will be conducted at baseline and at 1-week, 1-month, 3-month and 6-month follow-ups.AnalysisDescriptive statistics will be used to calculate the feasibility measures. Effect sizes on psychological outcomes (ie, self-esteem, depressive symptoms and quality of life) will be estimated by mixed between-within subjects analysis of variance using partial eta squared with poverty (yes, no) entering into the model as a factor.Ethics and disseminationEthical approval has been obtained from the Hong Kong Polytechnic University Institutional Review Broad. We will obtain parental consent as our subjects are below 18 years old. Findings from this study will be disseminated via international publications and conferences.Trial registration numberNCT04875507.

The extension of the cosmic-ray spectrum beyond 1 petaelectronvolt (PeV; 1015 electronvolts) indicates the existence of the so-called PeVatrons—cosmic-ray factories that accelerate particles to PeV energies. We need to locate and identify such objects to find the origin of Galactic cosmic rays1. The principal signature of both electron and proton PeVatrons is ultrahigh-energy (exceeding 100 TeV) γ radiation. Evidence of the presence of a proton PeVatron has been found in the Galactic Centre, according to the detection of a hard-spectrum radiation extending to 0.04 PeV (ref. 2). Although γ-rays with energies slightly higher than 0.1 PeV have been reported from a few objects in the Galactic plane3–6, unbiased identification and in-depth exploration of PeVatrons requires detection of γ-rays with energies well above 0.1 PeV. Here we report the detection of more than 530 photons at energies above 100 teraelectronvolts and up to 1.4 PeV from 12 ultrahigh-energy γ-ray sources with a statistical significance greater than seven standard deviations. Despite having several potential counterparts in their proximity, including pulsar wind nebulae, supernova remnants and star-forming regions, the PeVatrons responsible for the ultrahigh-energy γ-rays have not yet been firmly localized and identified (except for the Crab Nebula), leaving open the origin of these extreme accelerators. Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

Direct-to-consumer genetic testing (DTCGT) is gaining popularity in Hong Kong (HK). As DTCGT forgoes specialist medical involvement, healthcare professionals have raised concerns regarding its validity, utility, and the public's ability to interpret DTCGT results. Thus, genetic counseling (GC) is recommended to facilitate understanding of DTCGT. This study aimed to investigate HK public's perception toward DTCGT and the importance of GC in DTCGT. A total of 304 HK adults were invited to complete a 37-item survey online. Participants' genomic literacy, understanding and attitude toward DTCGT and GC, and responses to a mock DTCGT scenario were assessed. 48% of participants were aware of DTCGT while 82% indicated an interest. 30% of participants were aware of GC services in HK; 49% were interested in GC services for understanding DTCGT results. Participants scored on average 7.6/11 in the genomic sequencing knowledge scale and were weak in limitations of genomic testing. In the mock DTCGT scenario, 73% of participants expressed concern with the positive results initially. After being explained limitations of DTCGT, 40% of participants reported decreased concern. Reduced perceived helpfulness in medical management and lifestyle modification were also reported by 35% and 27%, respectively. This HK population demonstrated a high level of awareness and interest in DTCGT. As potential DTCGT users, they might experience excess concern and overestimate the usefulness of positive DTCGT results, particularly in medical management. The importance of GC to educate and guide interpretation of DTCGT results is supported; yet the awareness and access of GC services is inadequate in HK.

We revisit QCD calculations of radiative heavy meson decay form factors by including the subleading power corrections from the twist-two photon distribution amplitude at next-to-leading-order in $\alpha_s$ with the method of the light-cone sum rules (LCSR). The desired hard-collinear factorization formula for the vacuum-to-photon correlation function with the interpolating currents for two heavy mesons is constructed with the operator-product-expansion technique in the presence of evanescent operators. Applying the background field approach, the higher twist corrections from both the two-particle and three-particle photon distribution amplitudes are further computed in the LCSR framework at leading-order in QCD, up to the twist-four accuracy. Combining the leading power "point-like" photon contribution at tree level and the subleading power resolved photon corrections from the newly derived LCSR, we update theory predictions for the nonperturbative couplings describing the electromagnetic decay processes of the heavy mesons $H^{\ast \, \pm} \to H^{\pm} \, \gamma$, $H^{\ast \, 0} \to H^{0} \, \gamma$, $H_s^{\ast \, \pm} \to H_s^{\pm} \, \gamma$ (with $H=D, \, B$). Furthermore, we perform an exploratory comparisons of our sum rule computations of the heavy-meson magnetic couplings with the previous determinations based upon different QCD approaches and phenomenological models., Comment: 39 pages, 4 figures

The application of day surgery on thoracic surgery is just started, and the innovation of surgical robots and their application on thoracic surgery bring new opportunities to the development of thoracic day surgery. However, the clinical practice of robot-assisted thoracic day surgery (RTDS) in China still has challenges and disagreements. Based on the experience of domestic experts in the field of RTDS clinical practice, this review discussed several key points of RTDS, including the future direction of RTDS, adjusting the indications according to their own conditions for the institutions carrying out RTDS, the robot-assisted advantage of RTDS being brought into play during the operation, and the perfect post-discharge follow-up mechanism being an important guarantee for the safe development of RTDS, to promote the application progress of RTDS in China.日间手术在胸外科领域的应用目前仍处于起步阶段，而近年来机器人辅助胸腔镜手术在胸外科的应用为胸外科日间手术的推广普及带来了新的契机。但目前国内机器人胸外科日间手术（RTDS）的临床应用仍存在诸多挑战与分歧。本文立足国内相关领域专家在RTDS临床实践中的心得体会，讨论了RTDS目前的焦点问题，从RTDS未来方向、开展RTDS的机构可根据自身条件调整适应证、减少创伤、严格出院标准、完善出院后随访机制5个方面予以探讨，以期促进RTDS在国内应用的普及与进步。.

We report the discovery of a new unidentified extended $\gamma$-ray source in the Galactic plane named LHAASO J0341+5258 with a pre-trial significance of 8.2 standard deviations above 25 TeV. The best fit position is R.A.$=55.34^{\circ}\pm0.11^{\circ}$ and Dec$=52.97^{\circ}\pm0.07^{\circ}$. The angular size of LHAASO J0341+5258 is $0.29^\circ \pm 0.06^\circ_{stat} \pm0.02^\circ_{sys}$. The flux above 25 TeV is about $20\%$ of the flux of Crab Nebula. Although a power-law fit of the spectrum from 10 TeV to 200 TeV with the photon index $\alpha=2.98 \pm 0.19_{stat} \pm 0.02_{sys}$ is not excluded, the LHAASO data together with the flux upper limit at 10 GeV set by the Fermi LAT observation, indicate a noticeable steepening of an initially hard power-law spectrum %($\alpha \leq 1.75$) spectrum with a cutoff at $\approx 50$ TeV. We briefly discuss the origin of UHE gamma-rays. The lack of an energetic pulsar and a young SNR inside or in the vicinity of LHAASO J0341+5258 challenge, but do not exclude both the leptonic and hadronic scenarios of gamma-ray production., Comment: Accepted by APJL

Recently, the LHAASO Collaboration published the detection of 12 ultrahigh-energy γ-ray sources above 100 TeV, with the highest energy photon reaching 1.4 PeV. The first detection of PeV γ rays from astrophysical sources may provide a very sensitive probe of the effect of the Lorentz invariance violation (LIV), which results in decay of high-energy γ rays in the superluminal scenario and hence a sharp cutoff of the energy spectrum. Two highest energy sources are studied in this work. No signature of the existence of the LIV is found in their energy spectra, and the lower limits on the LIV energy scale are derived. Our results show that the first-order LIV energy scale should be higher than about 10^{5} times the Planck scale M_{Pl} and that the second-order LIV scale is10^{-3}M_{Pl}. Both limits improve by at least one order of magnitude the previous results.

This systematic review aimed to assess the impact of biologic disease-modifying antirheumatic drugs (bDMARDs) use on the risk of fracture in rheumatoid arthritis (RA) by conducting a pooled analysis of adjusted outcomes from individual studies.PubMed, Embase, and BioMed Central were searched up to 20th January 2021. Multivariable-adjusted odds ratios (OR) or matched estimates on the impact of bDMARDs on fracture risk were pooled.Nine studies were included. We found no statistically significant difference in the risk of fractures in RA patients using bDMARDs vs. non-users. On sensitivity analysis, we found no change in the significance of the effect size on exclusion of any study. There was no statistically significant difference in fracture risk in studies only on tumor necrosis factor (TNF) inhibitors, as well as those including any bDMARDs. Pooled analysis of only three studies indicated a statistically significant reduction in vertebral fractures in bDMARD users vs. non-users.Within the ambit of several limitations of our review, there seems to be no impact of bDMARDs on the fracture risk in RA patients. Further studies evaluating the type and duration of bDMARD therapy with meticulous adjustment of confounding factors are required to strengthen current evidence.

We report the discovery of an extended very-high-energy (VHE) gamma-ray source around the location of the middle-aged (207.8 kyr) pulsar PSR J0622+3749 with the Large High-Altitude Air Shower Observatory (LHAASO). The source is detected with a significance of 8.2σ for E25 TeV assuming a Gaussian template. The best-fit location is (right ascension, declination) =(95.47°±0.11°,37.92°±0.09°), and the extension is 0.40°±0.07°. The energy spectrum can be described by a power-law spectrum with an index of -2.92±0.17_{stat}±0.02_{sys}. No clear extended multiwavelength counterpart of the LHAASO source has been found from the radio to sub-TeV bands. The LHAASO observations are consistent with the scenario that VHE electrons escaped from the pulsar, diffused in the interstellar medium, and scattered the interstellar radiation field. If interpreted as the pulsar halo scenario, the diffusion coefficient, inferred for electrons with median energies of ∼160 TeV, is consistent with those obtained from the extended halos around Geminga and Monogem and much smaller than that derived from cosmic ray secondaries. The LHAASO discovery of this source thus likely enriches the class of so-called pulsar halos and confirms that high-energy particles generally diffuse very slowly in the disturbed medium around pulsars.

Supplemental material, sj-docx-2-hpq-10.1177_1359105321990806 for Relationships between resilience and quality of life in parents of children with cancer by Y. H. Luo, W. H. C. Li, A. T. Cheung, L. L. K. Ho, W. Xia, X. L. He, J. P. Zhang and J. O. K. Chung in Journal of Health Psychology

Supplemental material, sj-docx-3-hpq-10.1177_1359105321990806 for Relationships between resilience and quality of life in parents of children with cancer by Y. H. Luo, W. H. C. Li, A. T. Cheung, L. L. K. Ho, W. Xia, X. L. He, J. P. Zhang and J. O. K. Chung in Journal of Health Psychology

Supplemental material, sj-pdf-6-hpq-10.1177_1359105321990806 for Relationships between resilience and quality of life in parents of children with cancer by Y. H. Luo, W. H. C. Li, A. T. Cheung, L. L. K. Ho, W. Xia, X. L. He, J. P. Zhang and J. O. K. Chung in Journal of Health Psychology

We report the discovery of a UHE gamma-ray source, LHAASO J2108+5157, by analyzing the LHAASO-KM2A data of 308.33 live days. Significant excess of gamma-ray induced showers is observed in both energy bands of 25-100 TeV and $\gt$100 TeV with 9.5 sigma and 8.5 sigma, respectively. This source is not significantly favored as an extensive source with the angular extension smaller than the point-spread function of KM2A. The measured energy spectrum from 20 to 200 TeV can be approximately described by a power-law function with an index of -2.83$\pm$ 0.18stat. A harder spectrum is demanded at lower energies considering the flux upper limit set by Fermi-LAT observations. The position of the gamma-ray emission is correlated with a giant molecular cloud, which favors a hadronic origin. No obvious counterparts have been found, deeper multiwavelength observations will help to shed new light on this intriguing UHE source., Comment: 12 pages, 7 figures, accepted by ApJL

Supplemental material, sj-doc-1-hpq-10.1177_1359105321990806 for Relationships between resilience and quality of life in parents of children with cancer by Y. H. Luo, W. H. C. Li, A. T. Cheung, L. L. K. Ho, W. Xia, X. L. He, J. P. Zhang and J. O. K. Chung in Journal of Health Psychology

Hepatocellular carcinoma (HCC) is an invasive malignant tumor with high mortality rate. Long non-coding RNA (lncRNA) MAFG-AS1 has been showed to play an oncogenic role in several malignant tumors. Nonetheless, the exact role of MAFG-AS1 in the progression of HCC has not been fully elucidated.Real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot were used to detect the mRNA and protein expression of MAFG-AS1 in HCC tissues and cells. Cell counting kit-8 (CCK-8), transwell and tubule formation assays were applied to uncover the proliferation, migration, invasion and tumor angiogenesis of HCC cells, respectively. RNA binding protein immunoprecipitation (RIP) assay and Luciferase reporter gene assay were employed to explore the molecular mechanism. In addition, Xenograft assay was used to investigate the effect of MAFG-AS1 in vivo.MAFG-AS1 was highly expressed in HCC tissues and cells. Attenuation of MAFG-AS1 evidently suppressed the proliferation, migration, invasion and tumor angiogenesis of HCC cells, suggesting that MAFG-AS1 played an oncogenic role in HCC. MiR-3196 was sponged by MAFG-AS1, and OTX1 was a downstream target of miR-3196 in HCC. In addition, OTX1 expression was negatively associated with miR-3196 but positively associated with MAFG-AS1 in HCC tissues. Overexpression of OTX1 could abolish the repressive influence of MAFG-AS1 inhibition on the proliferation, migration, invasion and tumor angiogenesis of HCC cells.MAFG-AS1 facilitated the progression of HCC via targeting miR-3196/OTX1 axis, which might be used as a new insight for HCC treatment.

At Taiwan Photon Source (TPS), the main liquid-nitrogen (LN2) transfer line of length 600 m for beamline endstations was installed in 2015. It formerly supplied LN2 to maximum 24 beamline endstations. Beamline endstation 13A, of which the aim is advanced and general studies of biological structures and structural kinetics in solution or condensed forms under environmental simulations, from atomic to micrometre scale and time resolution from microsecond to minute, was installed during 2018 and 2019. We designed and self-manufactured one LN2 transfer line according to the requirement of beamline endstation 13A, to supply LN2 into the double-crystal monochromator (DCM), to solve the problem of thermal deformation of the crystal. Otherwise the keep-full device was designed to replace the phase separator of the chiller. In this paper we present the pipeline design, performance testing, keep-full device, pressure reducer, noise reduction and heat-load measurement.

Helium is an expensive consumable in cryogenic facilities and is used widely in space, medical and energy research. At NSRRC, liquid helium is used as a coolant for superconducting magnets and SRF cavities . Minor contaminants such as nitrogen, oxygen, moisture and oil will be picked up when liquid helium circulates in large scale cryogenic systems and such contaminants can crystalize and cause damage to the cold box turbo expanders resulting in system damage and failure . Therefore, a helium purification system is designed as an integral part of the cryogenic system to conserve helium by providing 99.9995% pure helium to the liquefier after eliminating contaminants. The NSRRC helium purification process is based on two principles, the first one being a cryo-sorption device using activated charcoal and a molecular sieve and the other being a cryo-condensation unit using a tubular heat exchanger. The purifier has been designed to purify impure helium with overestimated contaminants of as much as 2.5% nitrogen and 2.5% oxygen with a mass flow rate of 475 nm3/hr and delivering a pressure of 17 bar(a) of impure helium to the purifier, the actual impurity will be much lower than the actual design contaminants. In this paper, calculation and design of the helium purification system and components composed of one double pipe counter flow heat exchanger, one vessel and tube heat exchanger, one pre-cooler and one charcoal vessel will be discussed together with charcoal mass requirement calculations and design of other components. In NSRRC, helium is liquefied and is used as a coolant for the SRF system and for cryogenic undulators. During a cryogenic cycle in the cryogenic system, helium may pick up contaminants such as moisture, oxygen, oil, and nitrogen, which have a higher freezing point than liquid helium and will crystalize. These frozen impurities will then affect plant capacity and operation such as alternating flow characteristics, damaging moving parts like turbines in the cold box causing the overall cooling efficiency to drop. Eliminating the contaminants is therefore very important for the cryogenic system.

To improve the bioactivity of titanium alloy (Ti-6Al-4V), CaO-SiO

Severe and critical coronavirus pneumonia 2019 (COVID-19) often occurs in elder patients with multiple comorbidities, and severe hypoxemia events constitute a key factor for the deterioration of some cases. The critical type of COVID-19 could progress into acute respiratory distress syndrome and multi-organ dysfunction, which are the major causes of death. Early non-invasive ventilation (NIV) treatment of possible pathophysiological abnormalities is helpful to improve prognosis. Close monitoring of oxygenation, reducing patients' oxygen consumption, active psychological intervention, and rapid handling of severe hypoxemia events are the key factors for successful NIV treatment. In addition, active adjuvant therapies such as correcting coagulation dysfunction, providing proper nutritional support, accurate volume control, and safe individualized blood glucose monitoring are of great significance.重型和危重型新型冠状病毒肺炎常常发生于高龄及多合并疾病患者，严重低氧事件是造成部分病例病情恶化的重要因素。危重型可进展为急性呼吸窘迫综合征及多器官功能障碍，是造成死亡的重要原因。针对可能的病生理异常，及早开始无创通气治疗有助于改善预后。严密监护氧合情况、降低患者氧耗量、积极心理干预、迅速处理低氧事件是无创通气成功治疗的关键因素。积极纠正凝血功能紊乱、合理的营养支持、准确的容量控制和安全个体化的血糖监控等治疗具有重要意义。.

We present an improved calculation of the strong coupling constants $g_{D^*D\rho}$ and $g_{B^*B\rho}$ in light-cone sum rules including the one-loop QCD corrections of leading power with $\rho$ meson distribution amplitudes. We further compute the subleading-power corrections from two-particle and three-particle higher-twist contributions at leading order up to twist-4 accuracy. The next-to leading order corrections to leading power contribution offset the subleading-power corrections to some extend numerically, and our numerical results are consistent with previous works from sum rules. The comparisons between our results and the existing model-dependent estimations are also made., Comment: 25 pages, 2 figures

The Water Cherenkov Detector Array (WCDA) is a major component of the Large High Altitude Air Shower Array Observatory (LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. The WCDA is aimed at the study of TeV $\gamma$-rays. In order to evaluate the prospects of searching for TeV $\gamma$-ray sources with the WCDA, we present in this paper a projection for the one-year sensitivity of the WCDA to TeV $\gamma$-ray sources from TeVCat (footnote: http://tevcat.uchicago.edu) using an all-sky approach. Out of 128 TeVCat sources observable to the WCDA up to a zenith angle of $45^\circ$, we estimate that 42 would be detectable for one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei (AGN)., Comment: 10 pages,10 figures, it is to be published in Chinese Physics C

The main scientific goal of the LHAASO WFCTA experiment is to measure the cosmic ray energy spectra and composition from 10 TeV to 1 EeV. Cherenkov photons in the extensive air shower measured by the SiPM camera of Cherenkov telescopes can be used to reconstruct the cosmic ray energy. The absolute calibration of the camera is a crucial step to achieve the accurate measurement of the cosmic ray energy spectrum. A multi-wavelength cylindrical illuminator based on LEDs is developed and mounted inside the telescope to calibrate and monitor the camera, and the illuminator’s stability is better than 0.5% under the temperature variation from -26 to 26 ° C. A portable probe with a single photoelectron resolution of 21.6% is developed. After calibration by National Institute of Metrology, China (NIM), the probe is taken to the LHAASO site to measure the absolute photon density of the cylindrical illuminator inside the telescope. Based on the illuminator with known photon density, the photon conversion factor of the camera can be calibrated, and the overall calibration uncertainty is less than 2.6%.

The newly described species, Ziziphus budhensis was confirmed as Chinese Jujuba, Z. xiangchengensis on the basis of their DNA analyses. Z. budhensis was explained as a new species on the basis of some morphological differences in 2015. In the Year 2016, the DNA samples were collected from the type locality of Nepal, and the molecular analyses were carried out. The type specimens and the other available images from the different herbariums were examined. Besides, the protologue and the type images were studied carefully. The result showed that though there were some differences in the habit and the habitat of the plant, the previously described new species, Z. budhensis was found to be same as the Chinese species, Z. xiangchengensis. This study also showed the importance of the molecular work of Z. budhensis and confirmed it morphologically distinct although it was very close to the Chinese species.Banko Janakari, Vol. 27, No. 1, page: 55-59

In this paper, we demonstrated the application of the monitoring and control system on the unceremonious electrical testing equipment which is unintentionally designed for the testing laboratories. The operating temperature and current would be under surveillance of our design product using the concept of the Internet of Things (IoT). The power supply of the electrical testing equipment would be cut off when it is operated under any hazardous condition.

The objective of the present study was to investigate the relationship between adiponectin (APN)+45T/G and +276G/T polymorphisms and in-stent restenosis (ISR).A total of 150 patients treated with percutaneous coronary intervention (PCI) were divided into the ISR group and non-ISR group. The levels of blood biochemical indicators were measured, and APN+45T/G and +276G/T polymorphisms were detected by TaqMan probes.Cholesterol levels in the IRS group were significantly higher than those in the non-ISR group (p0.05). The frequency of the GG genotype and G allele of the APN+45T/G locus in the ISR group were significantly higher than those in the non-ISR group (p0.05). The frequency of the GG genotype and G allele of the APN+276G/T locus in the ISR group were significantly higher than those in the non-ISR group (p0.05).APN+45T/G and +276G/T polymorphisms were associated with susceptibility to ISR, and carrying the G allele of the APN+45T/G and +276G/T loci can significantly increase the risk of ISR.

哮喘和慢性阻塞性肺疾病（chronic obstructive pulmonary disease，慢阻肺）是最为常见的阻塞性肺疾病，肺功能检查在这两种疾病的诊断中均占据重要地位。虽然哮喘和慢阻肺的人群特征存在很大差异，但具体到某些患者，因为哮喘和慢阻肺的临床表现具有一定的相似性，或有两种疾病并存的情况，在具体鉴别诊断时并不容易。尤其是支气管哮喘患者因为各种原因出现不完全可逆气流受限时，和慢阻肺的鉴别就变得更加困难。因此，在目前被诊断为慢阻肺的患者中，可能会包括症状不典型的哮喘患者，或是由原先明确诊断为哮喘的患者病情进展而来的情况。这样就给哮喘和慢阻肺两者的诊断和标准化治疗，乃至临床研究带来一定的困扰。因此，有必要明确肺功能表现为不完全可逆气流受限的哮喘患者的临床和预后特征，以便为该类患者的临床诊治提供更为清晰的思路，并为慢阻肺临床研究中的研究对象的确认提供更为准确的依据。.

Real-time probabilistic seismic hazard assessment (PSHA) was developed in this study in consideration of its practicability for daily life and the rate of seismic activity with time. Real-time PSHA follows the traditional PSHA framework, but the statistic occurrence rate is substituted by time-dependent seismic source probability. Over the last decade, the pattern informatics (PI) method has been developed as a time-dependent probability model of seismic source. We employed this method as a function of time-dependent seismic source probability, and we selected two major earthquakes in Taiwan as examples to explore real-time PSHA. These are the Meinong earthquake (ML 6.6) of 5 February 2016 and the Hualien earthquake (ML 6.2) of 6 February 2018. The seismic intensity maps produced by the real-time PSHA method facilitated the forecast of the maximum expected seismic intensity for the following 90 d. Compared with real ground motion data from the P-alert network, our seismic intensity forecasting maps showed considerable effectiveness. This result indicated that real-time PSHA is practicable and provides useful information that could be employed in the prevention of earthquake disasters.

胸腔漏气综合征（TALS）是造血干细胞移植（HSCT）的一种少见并发症，与移植物抗宿主病（GVHD）和HSCT后迟发性非感染肺部并发症（LONIPC）密切相关。在LONIPC中，闭塞性细支气管炎（BO）和间质性肺病（ILD）是TALS的常见病因。TALS的发生是HSCT预后不良的独立危险因素，治疗反应差，其中与ILD相关的TALS较BO相关的TALS预后更差。积极防治GVHD以及对高危患者的早期识别是预防TALS的关键。.

We study the sensitivity of constraining the model independent Higgs-Z-Z coupling under effective theory up to dimension-6 operators at the future Higgs factory. Utilizing the current conceptual design parameters of the Circular Electron Positron Collider, we give the experimental limits for the model independent operators by the total Higgsstrahlung cross section and angular distribution of Z boson decay in the Higgs factory. Especially, we give very small sensitivity limit for the CP violation parameter $\tilde g$, which will be a clear window to test the Standard Model and look for New Physics signal., 15 pages, with 8 figures