Search

A simple technique for the fabrication of a two-dimensional periodic non-close-packed array of nonspherical particles is reported. The technique exploits the self-assembly of uniformly sized colloidal microspheres on the surface of a Si substrate followed by reactive ion etching (RIE) that converts the spheres into nonspherical particles.

The goal of this work was to study helicobacter pylori (HP) infection and gastric mucosa in cirrhotic patient. Method: The study was comparative (case-indicator) and transversal from October 2015 to June 2016 in the gastroenterology and hepatology center of CHU Gabriel Touré of Bamako. Hp was identified in pathologic center of CHU du point "G" de Bamako. Results: At the end of the study Hp infection frequency was 73.6% without significative differency with the comparative group (p= 0,200). The mean age was 46,3 ± 20,8 years. The sex ratio was 2,11. The home workers women were more represented (32.1%). Ascites and jaundice were the main signs respectively in 64.3% and 53.6% cases. The upper endoscopy found varices in 89.2% of cases. His worsen histological lesions were mucosal atrophy (17.8%) and intestinal metaplasy (14.2%). Conclusion: Helicobacter pylori infection is frequent in cirrhotic patient in our country with sometimes worsen histological lesions. [ABSTRACT FROM AUTHOR]

The mechanisms governing the tensile behavior of TiO2nanowires were studied by molecular dynamics simulations. Nanowires below a threshold diameter of about 10 Å transformed into a completely disordered structure after thermodynamic equilibration, whereas thicker nanowires retained their crystalline core. Initial elastic tensile deformation was effected by the reconfiguration of surface atoms while larger elongations resulted in continuous cycles of Ti−O bond straightening, bond breakage, inner atomic distortion, and necking until rupture. Nanowires have much better mechanical properties than bulk TiO2. Nanowires below the threshold diameter exhibit extraordinarily high stiffness and toughness and are more sensitive to strain rate. [ABSTRACT FROM AUTHOR]

An effective surface-enhanced Raman scattering (SERS) template based on a 3D hybrid Ag nanocluster (NC)-decorated ZnO nanowire array was fabricated through a simple process of depositing Ag NCs on ZnO nanowire arrays. The effects of particle size and excitation energy on the Raman scattering in these hybrid systems have been investigated using rhodamine 6G as a standard analyte. The results indicate that the hybrid nanosystem with 150 nm Ag NCs produces a larger SERS enhancement factor of 3.2 x 108, which is much higher than that of 10 nm Ag NCs (6.0 x 106) under 532 nm excitation energy. The hybrid nanowire arrays were further applied to obtain SERS spectra of the two-photon absorption (TPA) chromophore T7. Finite-difference time-domain simulations reveal the presence of an enhanced field associated with inter-wire plasmon coupling of the 150 nm Ag NCs on adjacent ZnO nanowires; such a field was absent in the case of the 10 nm Ag NC-coated ZnO nanowire. Such hybrid nanosystems could be used as SERS substrates more effectively than assembled Ag NC film due to the enhanced light-scattering local field and the inter-wire plasmon-enhanced electromagnetic field. [ABSTRACT FROM AUTHOR]

Patterned gallium nitride nanowires have been grown on n-Si(100) substrates by pulsed laser ablation. The nanowires are patterned using a physical mask, resulting in regions of nanowire growth of different density. These gallium nitride nanowires are single-crystalline with hexagonal wurzite structures. The electrical transport measurements of individual GaN nanowires show near-linear current-voltage characteristics. The estimated electron densities of these individual GaN nanowires range from 1.8-6.8 x 1018 cm[?]3. The field emission characteristics of these patterned gallium nitride nanowires show a turn-on field of 8.4 V um[?]1 to achieve a current density of 0.01 mA cm[?]2 and an enhanced field emission current density as high as 0.96 mA cm[?]2 at an applied field of 10.8 V um[?]1. The field emission results indicate that, besides crystalline quality as well as the low electron affinity of gallium nitride, density difference in the nanowires growth greatly enhances their field emission properties by reducing the screening between nanowires. [ABSTRACT FROM AUTHOR]

Patterned micropads made of metallic nanowires, 50 µm in diameter, are fabricated on a silicon substrate. An aluminium film patterned with SiO2is anodized to fabricate a patterned nanoporous alumina (PNA) template in which metallic nanowires are electrodeposited. SiO2that is deposited using the plasma-enhanced chemical vapour deposition process is demonstrated to be an effective barrier to anodization for the fabrication of high aspect ratio PNA templates. Current-voltage characteristics of an individual copper nanowire micropad display ohmic behaviour with a low resistance value of 5.5 m?. The nanowires are able to withstand the solder reflow process. Cu nanowire/Sn solder reflow reaction leads to Cu6Sn5intermetallic formation. These micropads made of metallic nanowires have the potential for application as chip to substrate interconnects. Nanostructure synthesis is carried out using standard microelectronics fabrication techniques that would enable easy integration of such nanodevices into routine silicon manufacturing. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to describe opportunities and challenges associated with the development and implementation of a program for supporting researchers underrepresented in biomedical research., Approach: We describe a case study of the All of Us Researcher Academy supported by the National Institutes of Health (NIH), including feedback from participants, instructors, and coaches., Findings: Lessons include the importance of inviting role models into learning networks, establishing and maintaining trusted relationships, and making coaches available for technical questions from researcher participants., Originality: Although research has focused on learning outcomes in science, technology, engineering, and mathematics at Minority Serving Institutions in the United States, literature tends to lack models for initiatives to improve everyday research experiences of faculty and researchers at such institutions or to encourage researcher use of public-use data such as that available through NIH's All of Us Research Program. The All of Us Researcher Academy offers a model that addresses these needs., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association.)

Helicobacter pylori (Hp) infection plays an important role in the genesis of peptic ulcer disease. In the absence of susceptibility testing, concomitant quadruple therapy is one of the most widely used eradication methods. In the absence of a study on four-drug therapy and the difficulty of studying antibiotic susceptibility in our context, we initiated this work in order to evaluate the efficacy of an empirical treatment with concomitant four-drug therapy currently available., Method: This was a prospective study from May 2020 to April 2021 in the Hepato Gastroenterology Department of the Gabriel Touré University Hospital, the "Les ETOILES" Clinics, "Promenade des Angevins", FARAKO". The study included peptic ulcer patients who underwent gastric biopsies for Hp, concomitant quadruple therapy, and patients were screened for endoscopic ulcer control with biopsies for Hp eradication at least four weeks after treatment., Result: We obtained an overall frequency of Hp infection at 79% of the general population in peptic ulcer disease. This frequency was 80% in duodenal ulcer and 77.4% in gastric ulcer. The mean age was 49.05 ±17.25 years with extremes of 22 and 105 years and a sex ratio of 2.4 M/F. Epigastric pain dominated the symptomatology and with 81.6% of cases. The eradication rate was 94.7% (36/38) of cases with a healing rate of 89.5% (34/38) of cases. Histological lesions remained almost constant after treatment., Conclusion: Concomitant quadruple therapy is effective on Hp eradication., (Le comité de rédaction se réserve le droit de renvoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de conserver un exemplaire du manuscrit, des figures et des tableaux.)

Aims: The goal of our work was to clarify the epidemiologicals, clinicals, etiologicals and prognostics of upper gastrointestinal bleeding at Segou Regional Hospital., Patients and Methods: This cross-sectional study, which took place from October 1, 2017 to September 31, 2018, involved patients hospitalized for digestive hemorrhage., Results: Upper gastrointestinal bleeding represented 9.7% of all hospitalizations. The mean age of the patients was 50, 94 ± 21, 6 years with a sex ratio of 1.6 in favor of men. Housewives and farmers were represented in 37.7% and 34% of cases. The main modes of disclosure were hematemesis and melena. Evolution was favorable with a mortality of around 34%., Conclusion: upper gastrointestinal bleeding is relatively common in our context. High mortality is linked to delayed treatment., (Le comité de rédaction se réserve le droit de renvoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de conserver un exemplaire du manuscrit, des figures et des tableaux.)

Purpose: The purpose of this study was to study hepatitis B virus infection in pregnant women., Method: This was a one-year descriptive cross-sectional study carried out in the Gynecology-Obstetrics Department of the Gabriel Touré University Hospital., Result: During this period, 796 pregnant people were seen in antenatal consultations. Ween rolled 500 pregnant women in whom the search for HBs Ag was carried out, a rate of 62.81%. Of these pregnant 85 had HBs Ag a prevalence of 17%. The average age of these women was 26.9±5.6 years. Our patients were paucipare sin 52.9%. Of these, 17.7% had a family history of chronic liver disease and 37.6% had once given birth in a referral health centre. Blood transfusion, polygamous focus and tattooing/scarification were the risk factors associated with HBs Ag carriage. Alarming clinical signs were absent in 95.2% of cases. Hepatic cytolysis and anaemia were foundin 28.8% and 76.3% of cases respectively; viral replication was observed in 13.6% of pregnant women with a high viral loadin 37.2%. Abdominal ultra sound was normal in 90.8% of cases and esophageal varices were present in 6% of women who performed eso-gastroduduedenal fibroscopy. Fibrosis was significant according to an APRI score in 3.4%., Conclusion: The prevalence of HBs A in pregnant women followed remains high., (Le comité de rédaction se réserve le droit de renvoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de conserver un exemplaire du manuscrit, des figures et des tableaux.)

The goal of this work was to study helicobacter pylori (HP) infection and gastric mucosa in cirrhotic patient., Method: The study was comparative (case-indicator) and transversal from October 2015 to June 2016 in the gastroenterology and hepatology center of CHU Gabriel Touré of Bamako. Hp was identified in pathologic center of CHU du point "G" de Bamako., Results: At the end of the study Hp infection frequency was 73.6% without significative differency with the comparative group (p= 0,200). The mean age was 46,3 ± 20,8 years. The sex ratio was 2,11. The home workers women were more represented (32.1%). Ascites and jaundice were the main signs respectively in 64.3% and 53.6% cases. The upper endoscopy found varices in 89.2% of cases. His worsen histological lesions were mucosal atrophy (17.8%) and intestinal metaplasy (14.2%)., Conclusion: Helicobacter pylori infection is frequent in cirrhotic patient in our country with sometimes worsen histological lesions., (Le comité de rédaction se réserve le droit de renvoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de conserver un exemplaire du manuscrit, des figures et des tableaux.)

Introduction: The term polyp refers to any relief formation on the digestive mucosa.The therapeutic endoscopic polypectomy is an effective method to colorectal polyp resection., Objective: The maingoal of this work is to study the endoscopic aspects of colo-rectal polyps and to bring our experience on their treatment with endoscopic polypectomy., Patients and Method: Our study was retrospective and descriptive from January 2013 to December 2017 in the endoscopic centers of hepato-gastroenterology department of CHU Gabriel Touré and clinic of "Promenade des angevins". The study concerned in whom polypectomy was performed., Results: A total of 49 patients were included in our study. The main age of our patients was 26.2 2±1.7 years and the sex-ratio was 3.9. The sessile polyps were more frequents with 53.1%. The average size of polyps was 8.7±3.7 mm. The rectum localization was more reported (40.8%). All polyps(100%) were resected in monoblock and we used diathermol cove in 57.1% patients and the cold clamp in 42.9%. Histologically, we had 18 cases of hyperplasia (36.7%), 8 cases of tubulous adenoma (16.3%), 2 cases of tubulo-vilous adenoma (4.1%) and 2 cases of juvenil adenoma (4.1%). One patient was died by perforation five days after the polypectomy., Conclusion: The frequency of colorectal polyps is not negligible in our context.Endoscopic colorectal polypectomy is effective therapeutic method for resection of colorectal polyps., (Le comité de rédaction se réserve le droit de renvoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de conserver un exemplaire du manuscrit, des figures et des tableaux.)

The effectiveness of different thermal treatments for inactivating two viruses in clams was evaluated. Soft-shell clam digestive glands experimentally contaminated with hepatitis A virus (HAV) or murine norovirus (MNV) were heated for 90, 180, or 300 seconds at 85°C or 90°C in glass vials or plastic bags with 200 g of soft-shell clam meat. Inactivation was measured by plaque assay and real-time reverse-transcription (RT)-polymerase chain reaction assay. Measured inactivation was similar using both assays. The 90°C for 90 seconds treatment reduced MNV-1 titer by 3.33 log cycles and HAV by 2.66 log cycles. At 90°C for 180 seconds, both MNV-1 and HAV were completely inactivated (titer reduced by 5.47 log cycles) in glass vials. In the presence of clam meat as well, HAV inactivation was complete at 90°C for 180 seconds. In general, HAV was more resistant to heat treatment than MNV-1, suggesting that it would require a more severe treatment than human norovirus for inactivation in soft-shell clams. The results of the present study should contribute to the development of strategies for controlling the spread of enteric viral illness via shellfish.

The main goal of our study was to evaluate cirrhosis course on one year. The study was prospective and longitudinal from January 2005 to December 2006 in the center of hepatology and gastro-enterology of CHU Gabriel Touré. The patients had one year follow up and examinated every three months. In this study 57 patients were included. Mean age was 41,5 + 15,3 years. Ascite and jaundice were the main clinical signs respectively 70.2% and 54.4%. Ascite or its increase was the most complication in 67.5% of cases (p = 0.002). The global mortality was 82.5% and it was high in the three first months, caused by hepatocellular carcinoma, digestive bleeding and hepatic encephalopathy respectively 33.3%, 27.3% and 15.2%. Abdomen pain, ascite and jaundice have an predictive value for high mortality (p between 3.10-3 et 10-7). Early examination, therapeutic observance and good management of cirrhosis complications could reduce the mortality.

A neonatal screening allows a preclinical diagnosis of major sickle cell syndromes and an early management of the affected children. That would improve their life quality and expectancy. The preliminary program was set up on 518 senegalese newborn aged from 1 to 4 days, and coming from all the country ethnic groups. Isoelectrofocalisation is the test used on dried blood eluate and the positive control on citrate agar gel. 478 samples out of 518 (92.5%) have been analysed. Haemoglobinopathy have been found in 11.1% of cases, distributed as follow: heterozygoty FAS and FAC: 9%, double heterozygoty FSC: 0.2% and homozygoty FSS: 1.9%. Sickle cell neonatal screening should be imperatively implemented, with regards in economical considerations. It would be relevant to integrate it in a larger program including information, training and genetic counselling in order to avoid homozygotes birth and to lower the spread of this disease.

In neuro-paediatry, echography is one of the easiest examinations to conduct. It is one of the most bearable, least traumatic and most informative. Furthermore, by utilizing the fontanelle window, brain structure can be discerned. In the light of these 75 observations, the authors establish echo-anatomical correlations and diagnostic strategy.