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Mechanical properties, such as the tensile anisotropy, of bcc metal sheets are significantly influenced by their rolling textures, so it is important to investigate the texture formation mechanisms in the metals in order to control their textures. A biaxial stress texture theory, which can be used to reveal the texture formation mechanism in bcc metal sheets by analyzing the grain rotation during rolling,—is put forward in this work. With the theory, rolling textures and deformation microstructures in W sheets are studied and it is demonstrated that two stable texture components, namely, (001)[110] and (111) $$[1\bar {1}0]$$ textures, are formed in the W sheet rolled to a large reduction (92.4%). The two textures can be converted between each other under the action of conjugate slips and cross slip, leading them to be the stable orientations in the W sheets. The deformation microstructures in the W sheets are investigated by trace analysis in a pole figure based on the biaxial stress texture theory, which shows a consistency between the predictions of the theory and experimental results.

It is well known that bromodomain-containing protein 4 (BRD4) has been thought as a promising target utilized for treating various human diseases, such as inflammatory disorders, malignant tumours, acute myelogenous leukaemia (AML), bone diseases, etc. For this study, molecular dynamics (MD) simulations, binding free energy calculations, and principal component analysis (PCA) were integrated together to uncover binding modes of inhibitors 8P9, 8PU, and 8PX to BRD4(1). The results obtained from binding free energy calculations show that van der Waals interactions act as the main regulator in bindings of inhibitors to BRD4(1). The information stemming from PCA reveals that inhibitor associations extremely affect conformational changes, internal dynamics, and movement patterns of BRD4(1). Residue-based free energy decomposition method was wielded to unveil contributions of independent residues to inhibitor bindings and the data signify that hydrogen bonding interactions and hydrophobic interactions are decisive factors affecting bindings of inhibitors to BRD4(1). Meanwhile, eight residues Trp81, Pro82, Val87, Leu92, Leu94, Cys136, Asn140, and Ile146 are recognized as the common hot interaction spots of three inhibitors with BRD4(1). The results from this work are expected to provide a meaningfully theoretical guidance for design and development of effective inhibitors inhibiting of the activity of BRD4.

Emerging evidences indicate bromodomain-containing proteins 2 and 4 (BRD2 and BRD4) play critical roles in cancers, inflammations, cardiovascular diseases and other pathologies. Multiple short molecular dynamics (MSMD) simulations combined with molecular mechanics generalized Born surface area (MM-GBSA) method were applied to investigate the binding selectivity of three inhibitors 87D, 88M and 89G towards BRD2 over BRD4. The root-mean-square fluctuation (RMSF) analysis indicates that the structural flexibility of BRD4 is stronger than that of BRD2. Moreover the calculated distances between the Cα atoms in the centres of the ZA_loop and BC_loop of BRD4 are also bigger than that of BRD2. The rank of binding free energies calculated using MM-GBSA method agrees well with that determined by experimental data. The results show that 87D can bind more favourably to BRD2 than BRD4, while 88M has better selectivity on BRD4 over BRD2. Residue-based free-energy decomposition method was utilized to estimate the inhibitor-residue interaction spectrum and the results not only identify the hot interaction spots of inhibitors with BRD2 and BRD4, but also demonstrate that several common residues, including (W370, W374), (P371, P375), (V376, V380) and (L381, L385) belonging to (BRD2, BRD4), generate significant binding difference of inhibitors to BRD2 and BRD4.

HIV-1 protease (PR) is thought to be efficient targets of anti-AIDS drug design. Molecular dynamics (MD) simulations and multiple post-processing analysis technologies were applied to decipher molecular mechanism underlying binding of three drugs Lopinavir (LPV), Nelfinavir (NFV) and Atazanavir (ATV) to the PR. Binding free energies calculated by molecular mechanics generalized Born surface area (MM-GBSA) suggest that compensation between binding enthalpy and entropy plays a vital role in binding of drugs to PR. Dynamics analyses show that binding of LPV, NFV and ATV highly affects structural flexibility, motion modes and dynamics behaviour of the PR, especially for two flaps. Computational alanine scanning and interaction network analysis verify that although three drugs have structural difference, they share similar binding modes to the PR and common interaction clusters with the PR. The current findings also confirm that residues located interaction clusters, such as Asp25/Asp25��, Gly27/Gly27��, Ala28/Ala28��, Asp29, Ile47/Ile47��, Gly49/Gly49��, Ile50/Ile50��, Val82/Val82�� and Ile84/Ile84, can be used as efficient targets of clinically available inhibitors towards the PR.

This study aimed to investigate whether percutaneous vertebral augmentation (PVA) was associated with clinical and radiological subsequent adjacent fractures in patients with osteoporotic vertebral compression fractures.The systematic review was performed following PRISMA guidelines. Data were retrieved from PubMed, EMBASE, Cochrane Library, Google Scholar, Web of Science, and ClinicalTrial.gov, from database inception to March 2020. Eligible studies were those that assessed subsequent adjacent fractures after PVA in comparison with conservative treatment (CT). The number of patients with adjacent secondary vertebral fractures was calculated, and the pooled risk ratio (RR) with its 95% confidence intervals (95% CI) was used. Moreover, heterogeneity, sensitivity, and publication bias analyses were performed.Twenty-four studies were included finally. Moreover, 20/421 (4.75%) patients from the PVA group and 25/359 (6.96%) patients from the CT group had clinical subsequent adjacent fractures, and 46/440 (10.45%) patients from the PVA group and 36/444 (8.10%) patients from the CT group had radiological subsequent adjacent fractures. Both had no significant difference between the two groups (RR = 0.67, 95% CI [0.38, 1.19], p = 0.17)/(RR = 1.13, 95% CI [0.75, 1.70], p = 0.576). However, the number of fractured vertebrae was higher in the PVA group than in the CT group (RR = 1.41, 95% CI [1.03, 1.93], p = 0.03). A sensitivity analysis did not identify specific trials that seriously deflected. No obvious publication bias was identified.The systematic review revealed that PVA did not increase the incidence for subsequent adjacent fractures regardless of whether they were clinical or radiological fractures. However, PVA can increase the number of subsequent fractures at adjacent vertebral levels.

Recently, bromodomain-containing protein 9 (BRD9) has been a prospective therapeutic target for anticancer drug design. Molecular dynamics (MD) simulations combined with molecular mechanics generalized Born surface area (MM-GBSA) method were adopted to explore binding modes of three inhibitors (5SW, 5U2, and 5U6) to BRD9 and identify the hot spot of the inhibitor-BRD9 binding. The results indicate that the inhibitor 5SW has the strongest binding ability to BRD9 among the current three inhibitors. Furthermore, the rank of the binding free energies predicted by MM-GBSA approach agrees with that determined by the experimental values. In addition, inhibitor-residue interactions were computed by using residue-based free-energy decomposition method and the results suggest that residue His42 produces the CH-H interactions, residues Asn100, Ile53 and Val49 produce the CH-[Formula: see text] interactions with three inhibitors and Tyr106, Phe45 and Phe44 generate the π-π interactions with inhibitors. Notably, the residue Asn140 forms hydrogen bonding interactions with three inhibitors. This research is expected to provide useful molecular basis and dynamics information at atomic levels for the design of potent inhibitors inhibiting the activity of BRD9.

The GALILEO array is a high-efficiency γ -ray spectrometer, resident at the Legnaro National Laboratory (LNL)in Italy, and it is currently used in combination with the Si-ball EUCLIDES for the detection of charged-particles. The combined setup was used in the 6 Li+89Y experiment with incident energies of 22 MeV and 34 MeV to investigate the influence of breakup and transfer of weakly bound projectile on the fusion process. Using the coincidence by the charged particles and γ -rays, the different reaction channels can be clearly identified and the different reaction mechanisms can be clearly studied. It is shown that this facility can be used well to explore the fusion reaction mechanisms induced by weakly bound nuclei.

The protonation states of two aspartic acids in the catalytic strands of HIV-1 protease (PR) remarkably affect bindings of inhibitors to PR. It is requisite for the design of potent inhibitors towards PR to investigate the influences of Asp25/Asp25' protonated states on dynamics behaviour of PR and binding mechanism of inhibitors to PR. In this work, molecular dynamics (MD) simulations, MM-GBSA method and principal component (PC) analysis were coupled to explore the effect of Asp25/Asp25' protonation states on conformational changes of PR and bindings of Amprenavir and MKP97 to PR. The results show that the Asp25/Asp25' protonation states exert different impacts on structural fluctuations, flexibility and motion modes of PR. Dynamics analysis verifies that Asp25/Asp25' protonated states highly affect conformational dynamics of two flaps in PR. The binding free energy calculations results suggest that the Asp25/Asp25' protonated states obviously strengthen bindings of inhibitors to PR compared to the non-protonation state. Calculations of residue-based free energy decomposition indicate that the Asp25/Asp25' protonation not only disturbs the interaction network of inhibitors with PR but also stabilizes bindings of inhibitors to PR by cancelling the electrostatic repulsive interaction. Therefore, special attentions should be paid to the Asp25/Asp25' protonation in the design of potent inhibitors towards PR.

To explore the expression of LINC01093, a long non-coding ribonucleic acid (lncRNA) in non-small cell lung cancer (NSCLC) tissues, and cells and its regulatory role in NSCLC cell proliferation and invasion.The expression of LINC01093 in NSCLC tissues and cells was detected via quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) experiment. The specific sequences interfering in LINC01093 were designed and transiently transfected into A549 and SPCA-1 cells using LipofectamineTM 2000, and 48 later, the transfection efficiency was detected. Moreover, the impacts of small interfering (si)-LINC01093 on NSCLC cell proliferation were observed via methyl thiazolyl tetrazolium (MTT) and colony forming assays, the influence of LINC01093 on the cycle distribution of NSCLC cells was determined through flow cytometry, and the changes in the invasion and migration abilities of NSCLC cells were evaluated via transwell assay after interfering in the expression of LINC01093. Finally, the expression changes of the molecular markers in the protein kinase B (Akt) signaling pathway in the downstream of LINC01093 were detected via Western blotting.According to the results of qRT-PCR, the relative expression level of LINC01093 was up-regulated in NSCLC tissues and cells. After interfering in the expression of LINC01093, the results of MTT and colony forming assays revealed that the proliferation ability of NSCLC cells was weakened, according to the findings in the flow cytometry, the cells were arrested in G1/0 phase, the transwell assay results manifested that the cell migration and invasion abilities were weakened, and the results of the Western blotting suggested the changes in the expressions of molecular markers in the Akt signaling pathway.The expression of LINC01093 is upregulated in NSCLC tissues and cells, and it facilitates the proliferation, invasion, and metastasis of NSCLC cells via the Akt signaling pathway.

Gamma-ray angular distributions in oriented $$^{92}$$ Mo produced via the $$^{6}$$ Li+ $$^{89}$$ Y reaction were studied in this work. The characteristic $$\gamma $$ rays in $$^{92}$$ Mo were measured by means of the GALILEO array, which is composed of 25 Compton-suppressed HPGe detectors arranged in a nearly 2 $$\pi $$ geometry. A detailed analysis of the spin-alignment attenuation factors ( $$\alpha _2$$ ) for different excited states in $$^{92}$$ Mo was performed, by analyzing the measured angular distribution coefficients of several pure-E2 transitions. The relationship between $$\alpha _2$$ and the spin was established in $$^{92}$$ Mo and the 244-keV transition between the 5 $$^-_1$$ and 4 $$^+_1$$ states resulted to have a E1 + M2 character with a mixing ratio ( $$\delta $$ ) of $$-0.05^{+0.05}_{-0.06}$$ , consistent with shell model calculations.

CREB binding protein (CBP) and its paralog E1A binding protein (p300) are related to the development of inflammatory diseases, cancers and other diseases, and have been potential targets for the treatment of human diseases. In this work, interaction mechanism of three small molecules E3T, E3H, and E3B with CBP was investigated by employing molecular dynamics (MD) simulations, principal component analysis (PCA), and molecular mechanics/generalized born surface area (MM-GBSA) method. The results indicate that inhibitor bindings cause the changes of movement modes and structural flexibility of CBP, and van der Waals interactions mostly drive associations of inhibitors with CBP. In the meantime, the results based on inhibitor-residue interactions not only show that eight residues of CBP can strongly interact with E3T, E3H and E3B but also verify that the CH-CH, CH-π, and π-π interactions are responsible for vital contributions in associations of E3T, E3H and E3B with CBP. In addition, the H-O radial distribution functions (RDFs) were computed to assess the stability of hydrogen bonding interactions between inhibitors and CBP, and the obtained information identifies several key hydrogen bonds playing key roles in bindings of E3T, E3H and E3B to CBP. Potential new inhibitors have been proposed.

The aim of this study was to detect the expression of linc00703 in non-small cell lung cancer (NSCLC), and to explore the biological function and potential molecular mechanism of linc00703 in NSCLC using in vitro experiments.The carcinoma tissues and para-carcinoma tissues were collected from 32 patients diagnosed with NSCLC, from which the RNA was extracted. The relative expression of linc00703 in NSCLC tissues was detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The NSCLC cells and normal human bronchial epithelial cells were selected, in which the relative expression of linc00703 was determined via qRT-PCR. Next, the linc00703 overexpression plasmids were designed and synthesized, and then transiently transfected into NSCLC cells. After 48 h, the overexpression efficiency was detected. Finally, the changes in cell proliferation, apoptosis, cycle distribution and expressions of downstream molecular markers were determined using cell counting kit-8 (CCK8) assay, colony formation assay, flow cytometry and Western blotting, respectively, after overexpression of linc00703 in NSCLC cells.The results of qRT-PCR revealed that the expression of linc00703 was down-regulated by 5.14 times on average in 29 out of 32 cases of NSCLC tissues, and it was also down-regulated in NSCLC cells. Besides, it was found through CCK-8 assay, colony formation assay and flow cytometry that after overexpression of linc00703 in NSCLC cells, the cell proliferation was inhibited, the apoptosis was enhanced, and the cell cycle was arrested in G1/G0 phase. Furthermore, the results of Western blotting showed that after overexpression of linc00703, the protein expressions of cyclinD1 and cyclin-dependent kinase 4 (CDK4) declined, while those of cyclinE1 and CDK2 did not change.The expression of linc00703 is down-regulated in NSCLC, and it suppresses the occurrence and development of NSCLC via mediating the expression of cyclinD1/CDK4.

Aydın, Sezgin ( Aksaray, Yazar ), Level structures of Rn212 have been studied by in-beam γ-ray spectroscopic methods using the Bi209(Li6,3n)Rn212 reaction at beam energies of 28, 30, and 34 MeV. A number of new nonyrast states based on πh9/24 and πh9/23f7/2 configurations have been identified. A 3(-) collective state is also proposed at 2121 keV, which is most likely formed by mixing the octupole vibration with the 3- member of the πh9/23i13/2 multiplet. The level scheme is compared with large-scale shell model calculations and discussed in terms of excitations of valence protons and without contributions from the Pb208 core. An overall excellent agreement is obtained for states that can be described in this model space.

Lung adenocarcinoma is one of the most ordinary malignant tumors. Recent researches have proved that long noncoding RNAs (lncRNAs) are vital factors in many diseases. In this work, lncRNA SNHG14 was studied to identify its function in the development of lung adenocarcinoma.Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to detect SNHG14 expression in paired lung adenocarcinoma patients' tissue samples and cells. Then, the function of SNHG14 was detected through MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay, colony formation assay, and transwell assay in vitro. Besides, mechanism assays and the interaction between SNHG14 and miR-613 were conducted.SNHG14 was remarkably higher-expressed in lung adenocarcinoma tissues than in adjacent samples. Moreover, cell proliferation and invasion of lung adenocarcinoma were promoted via overexpression of SNHG14, while cell proliferation and invasion of lung adenocarcinoma were inhibited via silence of SNHG14. Moreover, RT-qPCR results revealed that miR-613 was downregulated via overexpression of SNHG14, while miR-613 was upregulated via knockdown of SNHG14. Further experiments showed that miR-613 was also a direct target of SNHG14 in lung adenocarcinoma.Our study suggests that SNHG14 enhances lung adenocarcinoma cell proliferation and invasion via targeting miR-613, which indicates that SNHG14 may be a potential therapeutic target in lung adenocarcinoma.

With the increasingly obvious role of plant evidence in case detection, forensic botany, which provides clues and evidence in crime scene investigation by using botanical research method has attracted growing attention. The common experimental techniques used in forensic botany are morphological examination, physical and chemical examination, molecular genetic examination, and so on. This paper briefly expounds the advantages and disadvantages of different test methods, summarizes the problems that need to be paid attention to in the application of forensic botany by arranging the related literatures and cases of forensic botanical research, in order to provide reference for scene investigation of cases.植物物证的法医学应用.随着植物物证在案件侦破过程中的作用日益明显，应用植物学研究方法为刑事案件提供线索、证据的“法医植物学”越来越受到关注。法医植物学常用的实验技术有形态学检验、理化检验、分子遗传学检验等。本文通过整理法医植物学研究的相关文献及案例，以列举的形式简要阐述不同检验方法的利弊，总结法医植物学应用中需要注意的问题，供案件现场勘验时参考。.法医学；植物；证据；综述.

This short paper presents the investigation of reaction mechanism induced by 6Li through a particle­γ coincidence measurement. The data have been taken from a 6Li+89Y experimentwhich is performed inINFN-LNL, Italy. In this experiment, the light charged particles are detected by a Si­ball, named EUCLIDES, and the γ rays are collected by a HPGe detector array, called GALILEO. In this contribution, scientific motivations, experimental details and some results, such as α­γ analysis, are presented.

The aim of this study was to explore the role of microRNA-601 (miR-601) in the proliferation and invasion of esophageal squamous cell carcinoma (ESCC) cells, thereby providing new thoughts for prognosis evaluation and targeted therapy of ESCC.23 pairs of ESCC tissue samples and adjacent normal tissues were collected, and the expression level of miR-601 was detected. Biological information analysis and Luciferase report gene assay were used to verify the potential target genes of miR-601. Then, three groups were established in ESCC cell line (TE-1) to perform similar experiments, including the miR-NC group, the miR-601 mimics group and the mimics + HDAC6 group. Cell counting kit-8 (CCK-8) assay was used to detect cell proliferation ability. Meanwhile, transwell assay and scratch-wound assay were applied to observe the effect of miR-601 on cell invasion and migration. Quantitative reverse transcription Polymerase Chain Reaction (qPCR) and Western blot assay were applied to determine the mRNA and protein expression changes after transfection.Compared with normal adjacent tissues and normal esophageal epithelial cells, the expression of miR-601 was significantly decreased in ESCC tissues and cells. HDAC6 was identified as a target gene of miR-601. The expression of HDAC6 in esophageal carcinoma cells transfected with miR-601 mimics was significantly down-regulated. The negative correlation between miR-601 and HDAC6 expression was assessed by qPCR and Western blot (WB) assay. Furthermore, miR-601 remarkably suppressed the proliferation of ESCC cells. Meanwhile, cell invasion and migration were also found markedly restricted after transfection of miR-601 mimics. However, the overexpression of HDAC6 significantly counteracted the effects of miR-601.MiR-601 suppressed the proliferation, invasion and migration of esophagus carcinoma cells by down-regulating HDAC6 expression.

Excited states of odd-odd nucleus 92Nb and odd-A nucleus 93Nb were populated in the 6Li+ 89Y reaction with an incident energy of 34 MeV. The processes that produce 92,93Nb and can be measured by a combination of light charged particle and gamma ray measurements are discussed. Twenty new transitions are observed and eight new levels are constructed in 92Nb, and in addition two new transitions are added to the level scheme of 93Nb. Using shell model calculations, the low-lying structure of 92Nb is investigated and compared with the experimental results.

Several zirconium isotopes are in the path of slow neutron capture (s) process, and the direct components of ($n,\ensuremath{\gamma}$) reactions can be derived from their neutron spectroscopic factors. In the present work, the angular distributions of ($^{12}\mathrm{C},^{13}\mathrm{C}$) and ($^{13}\mathrm{C},^{12}\mathrm{C}$) reactions on targets $^{90,92,94,96}\mathrm{Zr}$ were obtained using the high-precision Q3D magnetic spectrograph at the Beijing HI-13 tandem accelerator in China Institute of Atomic Energy. The distorted-wave Born approximation calculations were performed to extract the spectroscopic factors, using three different sets of Woods-Saxon potential parameters for these heavy-ion systems. The neutron spectroscopic factors for the ground state of $^{90--97}\mathrm{Zr}$ have been obtained and compared with other experimental data.

The measurement of one-neutron stripping cross sections for the $^{89}\mathrm{Y}(^{6}\mathrm{Li},^{5}\mathrm{Li})^{90}\mathrm{Y}^{*}$ reaction at 22 MeV and 34 MeV is reported, using both in-beam and off-beam $\ensuremath{\gamma}$-ray spectroscopy methods. Characteristic $\ensuremath{\gamma}$ lines of $^{90}\mathrm{Y}$ are clearly identified by both the $\ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma}$ and proton-$\ensuremath{\gamma}$ coincidence methods. The obtained cross section of one-neutron stripping at 34 MeV is found to be much smaller than that at 22 MeV. The one-neutron stripping cross sections measured for this system have the same order of magnitude as the one measured for the same reaction for the $^{6}\mathrm{Li}+^{96}\mathrm{Zr}$ system at energies around the Coulomb barrier. Parameter-free coupled reaction channel calculations agree quite well with the experimental data. Theoretical study of the effect of the one-neutron transfer on the elastic total fusion cross section is performed.

Investigation of the breakup and transfer effect of weakly bound nuclei on the fusion process has been an interesting research topic in the past several years. In comparison with radioactive ion beam (RIB), the beam intensities of stable weakly bound nuclei such as 6,7Li and 9Be, which have significant breakup probability, are orders of magnitude higher. Precise fusion measurements induced by these nuclei have already been performed. However, the conclusion of reaction dynamics was not clear and has contradiction. In order to have a proper understanding of the influence of breakup and transfer of weakly bound projectiles on the fusion process, the 6Li+89Y experiment with incident energies of 22 MeV and 34 MeV was performed on Galileo array in combination with Si-ball EUCLIDES at Legnaro National Laboratory (LNL) in Italy. Using the coincidence by the charged particles and γ-rays, the different reaction channels can be clearly identified.

Given that dealing with blocking of traditional target tracking algorithm is not enough, a target tracking method fused into dynamic salient features is proposed by simulating human visual mechanism to ensure accuracy and efficiency. First, the salient features of the bottom layer image, such as color, intensity, orientation, and motion, are extracted. These features are considered feature vectors fused into target tracking algorithm. An improved target tracking algorithm is proposed because local regional histogram of target is influenced by the background pixels of the background region. Experiment results show that the proposed target tracking algorithm is more accurate than the traditional tracking algorithm in dealing with blocking, thereby meeting the needs of complex scenes.

This prospective, randomized, phase III trial shows that prophylactic cranial irradiation prolongs disease-free survival, decreases the rate of cerebral metastases and does not affect quality-of-life for patients with fully resected postoperative pathologically confirmed stage IIIA-N2 non-small-cell lung cancer and high risk of cerebral metastases after adjuvant chemotherapy. Background This study compared prophylactic cranial irradiation (PCI) with observation in patients with resected stage IIIA–N2 non-small-cell lung cancer (NSCLC) and high risk of cerebral metastases after adjuvant chemotherapy. Patients and methods In this open-label, randomized, phase III trial, patients with fully resected postoperative pathologically confirmed stage IIIA–N2 NSCLC and high cerebral metastases risk without recurrence after postoperative adjuvant chemotherapy were randomly assigned to receive PCI (30 Gy in 10 fractions) or observation. The primary end point was disease-free survival (DFS). The secondary end points included the incidence of brain metastases, overall survival (OS), toxicity and quality of life. Results This trial was terminated early after the random assignment of 156 patients (81 to PCI group and 75 to control group). The PCI group had significantly lengthened DFS compared with the control group, with a median DFS of 28.5 months versus 21.2 months [hazard ratio (HR), 0.67; 95% confidence interval (CI) 0.46–0.98;P = 0.037]. PCI was associated with a decrease in risk of brain metastases (the actuarial 5-year brain metastases rate, 20.3% versus 49.9%; HR, 0.28; 95% CI 0.14–0.57;P Conclusion In patients with fully resected postoperative pathologically confirmed stage IIIA–N2 NSCLC and high risk of cerebral metastases after adjuvant chemotherapy, PCI prolongs DFS and decreases the incidence of brain metastases.

With the development of modern power grids to ultra-high voltage, large capacity and long-distance, the grounding short-circuit current of power systems is getting larger and larger, and higher requirements are put forward for the safe and stable operation of grounding systems.The importance of studying the corrosion status of grounding grids is even more prominent. In this paper, from both static and dynamic aspects, the corrosion state prediction methods of the grounding grid are discussed. And the prediction technology is prospected, it is pointed out that the development of a device combining detection and prediction techniques will fill the gap in the international arena. It can not only provide effective guidance for corrosion protection of grounding grids, but also can be applied to other fields.

Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) Middle East-Asia Minor 1 (MEAM1) is invasive and adaptive to varied environments throughout the world. The adaptability is closely related to genomic variation such as single nucleotide polymorphisms (SNPs) and insertions/deletions (indels). In order to elucidate the feature of SNPs and indels in MEAM1, and reveal the association between SNPs/indels and adaptive capacity to various environments, a computational approach with QualitySNP was used to identify reliable SNPs and indels on the basis of 9110-expressed sequence tags of MEAM1 present in the NCBI database. There were 575 SNPs detected with a density of 10.1 SNPs/kb and 6.4 SNPs/contig. Also, 237 transitions (39.3%) and 366 transversions (60.7%) were obtained, where the ratio of transitions to transversions was 0.65:1. In addition, 581 indels with a density of 14.1 indels/kb and 9.2 indels/contig were detected. Collectively, it showed that invasive MEAM1 has high SNPs density, and higher SNPs percentage than non-invasive B. tabaci species. A high SNPs density/percentage in MEAM1 yielded a high genomic variation that might have allowed it to adapt to varied environments, which provides some support to understand the invasive nature of MEAM1 at the genomic level. High levels of genomic variation are implicated in the level of adaptive capacity and invasive species are thought to exhibit higher levels of adaptive capacity than non-invasive species.

The angular distributions of 12 C + 90,92,94,96 Zr elastic scattering were measured with the Q3D magnetic spectrometer at the HI-13 tandem accelerator, Beijing. The real part of optical potential were extracted by analysing these angular distributions. The analysis enable us to avoid the influence of Coulomb effect and to observe the dependence of optical potential on the nuclear properties. With the deduced potential parameters, the experimental elastic scattering angular distributions can be reproduced very well. Formulas to infer global heavy-ion potential parameters were obtained then by analyzing the extracted optical potential parameters. The formulas can be used widely in heavy-ion nuclear reactions.

The influence of green tape thickness on the Bi-2223 phase formation and texture evolution in Ag/Ni composite-sheathed tapes fabricated by the “powder-in-tube” technique has been studied. Microstructural observations by SEM as well as critical current density (J c) measurements at 77 K, 0 T have been performed to analyze the performance of the tapes. The results show an important influence of the green tape thickness on the critical current depending on the content and texture of Bi-2223 phase. The J c increases with decreasing thickness. Moreover, texture measured by omega scans shows that the texture of the Bi-2223 phase is significantly influenced by the thickness of the green tape after the first and final sintering processes. Alignment of Bi-2223 grains in the thin tapes is much better. Higher performance of Ag/Ni composite-sheathed Bi-2223 tapes can be obtained by controlling the thickness of the green tapes.

10-meter-long Ag–Ni bimetallic sheathed (Bi,Pb)-2223 tapes with outer nickel sheath and inner silver sheath have been successfully fabricated by the “Powder in tube” technique. Microstructure and phase evolution studies by means of SEM and XRD, as well as critical current density (J c ) measurements have been performed. It is found that the nickel sheath and dwell time in the first sintering process have great influences on the texture evolution, phase transformation and J c of the Bi-2223/Ag/Ni tapes. Mono-filament (Bi,Pb)-2223 tape with a J c of 6656 A cm−2 and 61-filament tape with a J c of 12420 A cm−2 are obtained. Although using composite bimetallic sheaths can reduce production costs and improve mechanical properties of the Bi-2223 tapes, the Bi-2223 content and J c of Bi-2223/Ag/Ni tapes are relatively lower than that of traditional Bi-2223/Ag tapes. Meanwhile, due to higher Bi-2223 content and better alignment of Bi-2223 grains, tapes with 61-filament have higher J c than mono-filament tapes.

High spin states in 107Ag are studied via the 100Mo(11B, 4n)107 Ag reaction at an incident beam energy of 60 MeV. Prompt γ-γ coincidence and DCO ratios are measured by the detector arrays in CIAE. The level scheme has been updated and a new negative band belonging to 107Ag is identified. The new negative side band has been constructed and its configuration is tentatively assigned to πg9/2 ⊗ νh11/2(g7/2/d5/2).

The synthesis of Tb-doped GaN nanowires on Si (111) substrates through ammoniating Ga2O3 films doped with Tb was investigated. X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscope, high-resolution transmission electron microscopy and photoluminescence were used to characterize the composition, structure, morphology and optical properties of the products. The results show that the as-synthesized GaN nanowires doped with 3 at % Tb are of single-crystalline hexagonal wurtzite structure. The nanowires have diameters ranging from 30 to 50 nm and the lengths up to tens of micrometers. An f-f intra-atomic transition of rare earth at 545 nm corresponding to 5 D 4–7 F 5 of the Tb3+ and other two peaks related with doping are observed in PL spectrum, confirming the doping of Tb into GaN. The growth mechanism of GaN nanowires was discussed briefly.

The concentrations and distributions of total halogen (TX), extractable organohalogen (EOX) and extractable persistent organohalogen (EPOX) were determined in 20 kinds of yogurt specimens collected from Chinese supermarkets using neutron activation analysis (NAA) and gas chromatography equipped with a 63Ni electron capture detector (GC-ECD). The results indicated that the halogens in yogurt mainly existed as non-extractable organohalogen compounds. About 25–30% of EOX was EPOX. EOCl and EPOCl were the main organohalogen species in yogurt. The average concentration of the identified organochlorine, such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), was below 4% of EPOCl.

The spectroscopy of $^{73}\text{Ge}$ has been investigated via the $^{70}\text{Zn}(^{7}\text{Li},3np)^{73}\text{Ge}$ fusion-evaporation reaction. A previously known band built on the $\ensuremath{\nu}({f}_{5/2})$ orbital is extended up to higher-spin states and a new rotational band built on the $\ensuremath{\nu}({g}_{9/2})$ orbital is established. The observed band crossing and shape evolution induced by the alignment in $^{73}\text{Ge}$ are studied in comparison with the similar structures in the neighboring $N=41$ isotones and the cranked Woods--Saxon--Strutinsky calculations by means of total-Routhian-surface (TRS) methods. The inversion of the order of the ${g}_{9/2}$ neutron and the ${g}_{9/2}$ proton crossing frequency observed in the negative-parity $\ensuremath{\nu}({f}_{5/2})$ bands between $^{73}\text{Ge}$ and $^{75}\text{Se}$, $^{77}\text{Kr}$ can be ascribed to their different triaxial deformations. At higher spins, both the $\ensuremath{\nu}({f}_{5/2})$ and $\ensuremath{\nu}({g}_{9/2})$ bands in $^{73}\text{Ge}$ undergo a shape evolution with sizable alignments occurring. The characters of large signature splitting in $\ensuremath{\nu}({g}_{9/2})$ band of $^{73}\text{Ge}$ are discussed.

Excited states of the odd-odd nucleus $^{158}\mathrm{Tb}$ have been studied via the $^{154}\mathrm{Sm}(^{7}\mathrm{Li},3n)^{158}\mathrm{Tb}$ reaction at a beam energy of 27 MeV. The new level scheme of $^{158}\mathrm{Tb}$ involving a positive parity rotational band is established up to excitation energy $\ensuremath{\sim}2.3\phantom{\rule{4.pt}{0ex}}\mathrm{MeV}$ and spin $\ensuremath{\sim}17\ensuremath{\hbar}$. By comparing with the rotational bands in the neighboring nuclei $^{157}\mathrm{Tb}$ and $^{157}\mathrm{Gd}$, the configuration was tentatively assigned as $\ensuremath{\pi}{d}_{5/2}\ensuremath{\bigotimes}\ensuremath{\nu}{i}_{13/2}$, and the phenomenon of signature inversion is discussed.

Measurements of complete and incomplete fusion cross sections for $^{6}\mathrm{Li}+^{154}\mathrm{Sm}$ have been performed at energies above the Coulomb barrier by the online $\ensuremath{\gamma}$-ray method, to investigate the effect of breakup and inelastic couplings on the complete fusion (CF) of this weakly bound system. We show that inelastic excitation couplings have non-negligible effects, when compared with the breakup effect, for deformed nuclei at energies very close to the Coulomb barrier. The average CF suppression corresponding to dynamic breakup effects was found to be around 35%. The total fusion cross section is not affected by the breakup coupling. A comparison between the $^{6}\mathrm{Li}$-induced CF suppression for three different samarium isotopes shows that the breakup effect is larger for the more spherical isotope.

The measurements of complete fusion cross sections for $^{6}\mathrm{Li}+^{96}\mathrm{Zr}$ have been performed at energies around the Coulomb barrier by the online $\ensuremath{\gamma}$-ray method. The complete fusion cross sections at above-barrier energies were found to be suppressed by $\ensuremath{\sim}25%$. A comparison of the systematics of complete fusion suppression with the existing data for $^{6}\mathrm{Li}$+ heavy targets with the present results shows that the systematics of the suppression factor observed for $^{6}\mathrm{Li}$-induced fusion in the heavy mass region may not be consistent in lighter target mass region.

High-spin states in 171Ta were populated through the heavy-ion fusion-evaporation reaction 157Gd (19F, 5n)171Ta at 105MeV beam energy. Lifetimes of the levels of the πh 9/21/2[541] band have been measured by using the Doppler shift attenuation method. The transition quadrupole moments ( Q t) and the quadrupole deformation (β2) have been extracted. Both β2 and Q t values decrease slightly with increasing rotational frequency. The average β2 value of 0.26 is 18% larger than that of the πh 11/2 9/2[514] band. Total Routhian Surface calculations have been performed with the non-axial deformed Woods-Saxon potential and the predicted values of the quadrupole deformation β2 are in good agreement with that deduced from our lifetime measurement. The shape-driving effect is discussed.

The echo of a moving target for airborne Synthetic Aperture Radar (SAR) can be approximated by the chirp signal. The changeable sampling-rate processing technology (CSPT) proposed by us is an effective technique to detect the frequency modulation rate of a chirp signal, but the remaining Doppler frequency diminishes its performance. In this paper, the influence of remaining Doppler frequency on the performance of CSPT is analysed and a new algorithm proposed to eliminate the remaining Doppler frequencies of all chirp components simultaneously based on the signal reconstruction from its ambiguity function. Therefore the improved CSPT can achieve excellent detection performance for the chirp signal. This method is applied to airborne SAR moving target detection (MTD), and the detection scheme is presented. Finally, the improved CSPT is demonstrated by using raw ground clutter data combined with a simulated moving target.

High spin states in 107Ag have been studied via the 100Mo(11B, 4n)107Ag reaction at a beam energy of 60 MeV on the HI-13 tandem accelerator at the China Institute of Atomic Energy. By analyzing the gamma-gamma coincidence and their DCO ratios, a new level scheme of 107Ag is presented. The structures for the newly constructed bands are briefly discussed and tentatively assigned to be chiral doublet bands.

Investigation of the breakup and transfer effect of weakly bound nuclei on the fusion process has been an interesting research topic in the past several years. However, owing to the low intensities of the presently available radioactive ion beam (RIB), it is difficult to clearly explore the reaction mechanisms of nuclear systems with unstable nuclei. In comparison with RIB, the beam intensities of stable weakly bound nuclei such as 6,7 Li and 9 Be, which have significant breakup probability, are orders of magnitude higher. Precise fusion measurements have already been performed with those stable weakly bound nuclei, and the effect of breakup of those nuclei on the fusion process has been extensively studied. Those nuclei indicated large production cross sections for particles other than the α + x breakup. The particles are originated from non-capture breakup (NCBU), incomplete fusion (ICF) and transfer processes. However, the conclusion of reaction dynamics was not clear and has the contradiction.In our previous experiments we have performed 6 Li+96 Zr and 154 Sm at HI-13 Tandem accelerator of China Institute of Atomic Energy (CIAE) by using HPGe array. It is shown that there is a small complete fusion (CF) suppression on medium-mass target nucleus 96 Zr different from about 35% suppression on heavier target nucleus 154 Sm at near-barrier energies. It seems that the CF suppression factor depends on the charge of target nuclei. We also observed one neutron transfer process. However, the experimental data are scarce for medium-mass target nuclei.In order to have a proper understanding of the influence of breakup and transfer of weakly bound projectiles on the fusion process, we performed the 6 Li+89 Y experiment with incident energies of 22 MeV and 34 MeV on Galileo array in cooperation with Si-ball EUCLIDES at Legnaro National Laboratory (LNL) in Italy. Using particle-particle and particle-γ coincidences, the different reaction mechanisms can be clearly explored.

Survivin is a member of the inhibitor of apoptosis protein (IAP) family. It is overexpressed in most cancer tissues and induces resistance to radiation therapy. In this study, we investigated whether knockdown of survivin by siRNA could induce apoptosis and enhance radiosensitivity in oral squamous cell carcinoma cells (OSCC).Oral squamous cell carcinoma cell lines KB was subjected to radiotherapy, small interfering RNA (siRNA) targeting survivin was transfected into KB cells in vitro, then subjected to radiotherapy. After irradiation or/and siRNA transfection, viable and dead cells were counted to determine radiation sensitivity by MTT assay, proliferation by colony-forming ability and apoptosis was analyzed by flow cytometry. Tumor-bearing mice were irradiated with 6 Gy of 60 Co-γ radiator.The results showed knockdown of survivin in KB cells showed reduced cell proliferation and increased number of radiation-induced apoptosis. Apoptosis was increased by survivin silencing alone and increased further in combination with irradiation. Colony formation was significantly reduced by survivin silencing in combination with irradiation.Survivin silencing sensitizes KB cells toward irradiation. Survivin silencing in combination with radiation inhibits cell proliferation and colony formation significantly and increases apoptosis more than each single treatment alone. In addition, survivin silencing significantly enhanced inhibition of tumor growth and potentiated cell apoptosis by irradiation in KB xenografts. In conclusion, survivin silencing could enhance sensitivity of human KB cells to radiotherapy in vitro and in vivo.