144 results on '"Hüser, Jörg"'
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2. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms
3. Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
4. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension
5. IMI European Lead Factory — democratizing access to high-throughput screening
6. Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease
7. A New Therapeutic Framework for Atrial Fibrillation Drug Development
8. New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions
9. BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist
10. Vascular Protection and Decongestion Without Renin–Angiotensin–Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist
11. “Digital biomarkers” in preclinical heart failure models — a further step towards improved translational research
12. Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case
13. BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist.
14. Additional file 1 of Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
15. IMI European Lead Factory — democratizing access to high-throughput screening
16. A novel approach for quantification of the future unmet medical need in right ventricular dysfunction
17. The European Lead Factory
18. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy
19. Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it
20. A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3′,5′-cyclic monophosphate pathway
21. Telemetric hemodynamic assessment during anesthesia induction with propofol in experimental heart failure
22. Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage
23. Mitochondrial Calcium in Heart Cells: Beat-to-Beat Oscillations or Slow Integration of Cytosolic Transients?
24. Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure
25. A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway
26. Serum contains a potent factor that decreases β-adrenergic receptor-stimulated L-type Ca2+ current in cardiac myocytes
27. Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure.
28. Remote Left Ventricular Hemodynamic Monitoring Using a Novel Intracardiac Sensor
29. New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions
30. Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance
31. Serum contains a potent factor that decreases \(\beta\)-adrenergic receptor-stimulated L-type Ca\(^{2+}\) current in cardiac myocytes
32. A luminescence-based assay for sensitive nitric oxide detection
33. High‐throughput Screening for Targeted Lead Discovery
34. Functional Cell‐based Assays for Targeted Lead Discovery in High‐throughput Screening
35. An automated aequorin luminescence-based functional assay used to identify BAY 58-2667, a new NO-independent soluble guanylate cyclase activator
36. Local calcium gradients during excitation–contraction coupling and alternans in atrial myocytes
37. Image-based High-content Screening - A View from Basic Sciences.
38. Index.
39. Front Matter.
40. High-throughput Screening and Data Analysis.
41. Chemical Genetics: Use of High-throughput Screening to Identify Small-molecule Modulators of Proteins Involved in Cellular Pathways with the Aim of Uncovering Protein Function.
42. Biochemical Assays for High-throughput Screening.
43. High-throughput Screening for Targeted Lead Discovery.
44. Combinatorial Chemistry and High-throughput Screening.
45. Functional Cell-based Assays for Targeted Lead Discovery in High-throughput Screening.
46. Chemoinformatic Tools for High-throughput Screening Data Analysis.
47. Tools and Technologies that Facilitate Automated Screening.
48. Methods for Statistical Analysis, Quality Assurance and Management of Primary High-throughput Screening Data.
49. Appendix.
50. Intracellular Ca2+ Release Sparks Atrial Pacemaker Activity
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