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1. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Al-Rim, Ben, Bardtke, Lara, Beheim-Schwarzbach, Jörn Ilmo, Behn, Kerstin, Bergfeld, Leon, Bethke, Norma, Bleicker, Tobias, Briesemeister, Dana, Brumhard, Sophia, Conrad, Claudia, Dieckmann, Sebastian, Frey, Doris, Gabelich, Julie-Anne, Georg, Philipp, Gläser, Ute, Hasler, Lisbeth, Hetey, Andreas, Hiller, Anna Luisa, Horn, Alexandra, Hülso, Claudia, Kegel, Luisa, Koch, Willi, Krannich, Alexander, Kroneberg, Paolo, Lisy, Michelle, Mackeldanz, Petra, Maeß, Birgit, Münn, Friederike, Olk, Nadine, Peiser, Christian, Pohl, Kai, Hermel, Annelie, Rönnefarth, Maria, Rubisch, Carolin, Sanchez Rezza, Angela, Schellenberger, Isabelle, Schenkel, Viktoria, Schlesinger, Jenny, Schmidt, Sein, Schwanitz, Georg, Sinnigen, Anne-Sophie, Stubbemann, Paula, Tesch, Julia, Treue, Denise, Wendisch, Daniel, Zvorc, Saskia, Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, and Sander, Leif Erik

Published
2021
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2. American Cutaneous Leishmaniasis: Imported cases in Berlin 2000–2023.

Author

Lindner, Andreas K., Moreno-del Castillo, Maria Cristina, Wintel, Mia, Equihua Martinez, Gabriela, Richter, Joachim, Kurth, Florian, Pfäfflin, Frieder, Zoller, Thomas, Gertler, Maximilian, Georgi, Susanne, Nürnberg, Michael, Hülso, Claudia, Bernhard, Julian, Kotsias, Sarah Konopelska, Seigerschmidt, Antonio, van Loon, Welmoed, Mockenhaupt, Frank, Kampmann, Beate, and Harms, Gundel

Subjects
CUTANEOUS leishmaniasis, NEGLECTED diseases, TREATMENT effectiveness, AMPHOTERICIN B, BURULI ulcer, SKIN diseases
Abstract

Background: American Cutaneous Leishmaniasis (ACL) shows variable response to therapy, but data on species-specific treatment efficacy is scarce. We describe the clinical characteristics and outcome of patients with ACL imported to a tertiary centre in Germany and determine whether species-specific therapy according to the 2014 "LeishMan" group recommendations is associated with cure. Methods: A retrospective chart review was conducted at the Charité Institute of International Health in Berlin. We analysed data on PCR-confirmed ACL cases collected between 2000 and 2023. Systemic therapy included liposomal amphotericin B, miltefosine, pentavalent antimony, ketoconazole or itraconazole. Localized therapy included perilesional pentavalent antimony or paromomycin ointment. Cure was defined as re-epithelialization of ulcers or disappearance of papular-nodular lesions after 3 months of treatment. Logistic regression models were used to quantify the effect of species-specific systemic therapy on the outcome. Results: 75 cases were analysed. Most patients were male (62%), median age was 35 years, no patient had a history of immunosuppression. The most common reason for travel was tourism (60%), the most common destination was Costa Rica (28%), the median duration of illness was 8 weeks, and most patients presented with ulcers (87%). Lesions were complex in 43%. The most common Leishmania (L.) species was L. braziliensis (28%), followed by L. panamensis (21%). 51/73 (70%) patients were cured after initial therapy and 17/21 (81%) after secondary therapy. Cure after systemic therapy was more frequent when species-specific treatment recommendations were followed (33/45; 73%), compared to when not followed, (6/17; 35%, P = 0.008). This association was independent of age, sex, previous therapy, complex lesions, and Leishmania species (adjusted OR, 5.06; 95% CI, 1.22–24.16). Conclusions: ACL is a rare, imported disease in Germany. Complex lesions were common, challenging successful therapy. This study highlights the importance of identifying the parasite species and suggests that a species-specific approach to treatment leads to better outcomes. Author summary: American cutaneous leishmaniasis is a skin disease caused by parasites that are transmitted through the bite of sandflies. It is considered as a neglected tropical disease. In non-endemic countries like Germany, this disease is rarely seen and is imported by migrants or travellers who have been infected in tropical or subtropical areas of the Americas. Experts suggest that the treatment should be given depending on the specific parasite species found in the affected skin, but there is still a scarcity of information on the optimal management strategy. We analysed 75 American cutaneous leishmaniasis cases seen between 2000 and 2023 at our German medical centre. Most patients were men, around 35 years of age, who most commonly travelled to the Americas for tourism. We found that when using systemic medications (i.e., given by mouth, injection or drip into a vein), that were recommended for the specific parasite type, patients were more likely to be cured, with a 73% success rate, compared to a mere 35% success rate when those recommendations were not followed. This highlights the importance of identifying the species that is causing the disease, and suggests that tailoring treatment to the specific parasite species increases the chances of cure. [ABSTRACT FROM AUTHOR]

Published
2024
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3. A Multicenter Clinical Diagnostic Accuracy Study of SureStatus, an Affordable, WHO Emergency Use-Listed, Rapid, Point-Of-Care Antigen-Detecting Diagnostic Test for SARS-CoV-2

Author

Krüger, Lisa J., primary, Lindner, Andreas K., additional, Gaeddert, Mary, additional, Tobian, Frank, additional, Klein, Julian, additional, Steinke, Salome, additional, Lainati, Federica, additional, Schnitzler, Paul, additional, Nikolai, Olga, additional, Mockenhaupt, Frank P., additional, Seybold, Joachim, additional, Corman, Victor M., additional, Jones, Terry C., additional, Pollock, Nira R., additional, Knorr, Britta, additional, Welker, Andreas, additional, Weber, Stephan, additional, Sethurarnan, Nandini, additional, Swaminathan, Jayanthi, additional, Solomon, Hilda, additional, Padmanaban, Ajay, additional, Thirunarayan, Ma, additional, L, Prabakaran, additional, de Vos, Margaretha, additional, Ongarello, Stefano, additional, Sacks, Jilian A., additional, Escadafal, Camille, additional, Denkinger, Claudia M., additional, Assaad, Kholoud, additional, Fuhs, Andrea, additional, Harter, Christopher, additional, Schulze, Cristopher, additional, Schmitt, Gunter, additional, Fink, Martina, additional, Schirmer, Maximilian, additional, Small, Annika, additional, Meinlschmidt, Matthias, additional, Dürr, Valerie, additional, Schuckert, Alina, additional, Ellinghaus, Henrik, additional, Penning, Alexander, additional, Abutaima, Loai, additional, Kollatzsch, Mandy, additional, Wintel, Mia, additional, Kausch, Franka, additional, Hommes, Franziska, additional, Bölke, Alisa, additional, Bernhard, Julian, additional, Hülso, Claudia, additional, Linzbach, Elisabeth, additional, Rössig, Heike, additional, Gertler, Maximilian, additional, Burock, Susen, additional, von dem Busche, Katja, additional, and Stephanie, Stephanie, additional

Published
2022
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4. SARS-CoV-2 infection and transmission in school settings during the second COVID-19 wave: a cross-sectional study, Berlin, Germany, November 2020

Author

Theuring, Stefanie, Thielecke, Marlene, van Loon, Welmoed, Hommes, Franziska, Hülso, Claudia, von der Haar, Annkathrin, Körner, Jennifer, Schmidt, Michael, Böhringer, Falko, Mall, Marcus A, Rosen, Alexander, von Kalle, Christof, Kirchberger, Valerie, Kurth, Tobias, Seybold, Joachim, Mockenhaupt, Frank P, Bozkurt, Esna, Chylla, Tanja, Bothmann, Melanie, Demirtas, Esra, Gülec, llay, Haack, Verena, Haniel, Franziska, Horn, Philipp, Kindzierski, Sophia, Kollatzsch, Mandy, Kurzmann, Marco, Lieber, Sascha, Linzbach, Elisabeth, Peters, Frederike, Rössig, Heike, Santos de Oliveira, Rafael, Steger, Julia, Tuncer, Zümrüt, Voelskow, Vanessa, and Wiesmann, Christof

Subjects
Epidemiology, Cross-sectional study, Secondary infection, education, Attack rate, Asymptomatic, children, Germany, Virology, Pandemic, medicine, Humans, adolescents, Pandemics, Schools, SARS-CoV-2, Transmission (medicine), business.industry, Research, Public Health, Environmental and Occupational Health, Attendance, COVID-19, Confidence interval, Berlin, Cross-Sectional Studies, medicine.symptom, business, Demography
Abstract

Background School attendance during the COVID-19 pandemic is intensely debated. Aim In November 2020, we assessed SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes and connected households in Berlin, Germany. Methods We collected oro-nasopharyngeal swabs and blood samples, examining SARS-CoV-2 infection and IgG antibodies by RT-PCR and ELISA. Household members self-swabbed. We assessed individual and institutional prevention measures. Classes with SARS-CoV-2 infection and connected households were retested after 1 week. Results We examined 1,119 participants, including 177 primary and 175 secondary school students, 142 staff and 625 household members. SARS-CoV-2 infection occurred in eight classes, affecting each 1–2 individuals. Infection prevalence was 2.7% (95% confidence interval (CI): 1.2–5.0; 9/338), 1.4% (95% CI: 0.2–5.1; 2/140), and 2.3% (95% CI: 1.3–3.8; 14/611) among students, staff and household members. Six of nine infected students were asymptomatic at testing. We detected IgG antibodies in 2.0% (95%CI: 0.8–4.1; 7/347), 1.4% (95% CI: 0.2–5.0; 2/141) and 1.4% (95% CI: 0.6–2.7; 8/576). Prevalence increased with inconsistent facemask-use in school, walking to school, and case-contacts outside school. For three of nine households with infection(s), origin in school seemed possible. After 1 week, no school-related secondary infections appeared in affected classes; the attack rate in connected households was 1.1%. Conclusion School attendance under rigorously implemented preventive measures seems reasonable. Balancing risks and benefits of school closures need to consider possible spill-over infection into households. Deeper insight is required into the infection risks due to being a schoolchild vs attending school.

Published
2021

5. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Hillus, David, primary, Schwarz, Tatjana, additional, Tober-Lau, Pinkus, additional, Vanshylla, Kanika, additional, Hastor, Hana, additional, Thibeault, Charlotte, additional, Jentzsch, Stefanie, additional, Helbig, Elisa T, additional, Lippert, Lena J, additional, Tscheak, Patricia, additional, Schmidt, Marie Luisa, additional, Riege, Johanna, additional, Solarek, André, additional, von Kalle, Christof, additional, Dang-Heine, Chantip, additional, Gruell, Henning, additional, Kopankiewicz, Piotr, additional, Suttorp, Norbert, additional, Drosten, Christian, additional, Bias, Harald, additional, Seybold, Joachim, additional, Klein, Florian, additional, Kurth, Florian, additional, Corman, Victor Max, additional, Sander, Leif Erik, additional, Al-Rim, Ben, additional, Bardtke, Lara, additional, Beheim-Schwarzbach, Jörn Ilmo, additional, Behn, Kerstin, additional, Bergfeld, Leon, additional, Bethke, Norma, additional, Bleicker, Tobias, additional, Briesemeister, Dana, additional, Brumhard, Sophia, additional, Conrad, Claudia, additional, Dieckmann, Sebastian, additional, Frey, Doris, additional, Gabelich, Julie-Anne, additional, Georg, Philipp, additional, Gläser, Ute, additional, Hasler, Lisbeth, additional, Hetey, Andreas, additional, Hiller, Anna Luisa, additional, Horn, Alexandra, additional, Hülso, Claudia, additional, Kegel, Luisa, additional, Koch, Willi, additional, Krannich, Alexander, additional, Kroneberg, Paolo, additional, Lisy, Michelle, additional, Mackeldanz, Petra, additional, Maeß, Birgit, additional, Münn, Friederike, additional, Olk, Nadine, additional, Peiser, Christian, additional, Pohl, Kai, additional, Hermel, Annelie, additional, Rönnefarth, Maria, additional, Rubisch, Carolin, additional, Sanchez Rezza, Angela, additional, Schellenberger, Isabelle, additional, Schenkel, Viktoria, additional, Schlesinger, Jenny, additional, Schmidt, Sein, additional, Schwanitz, Georg, additional, Sinnigen, Anne-Sophie, additional, Stubbemann, Paula, additional, Tesch, Julia, additional, Treue, Denise, additional, Wendisch, Daniel, additional, and Zvorc, Saskia, additional

Published
2021
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6. SARS-CoV-2 infection and transmission in school settings during the second COVID-19 wave: a cross-sectional study, Berlin, Germany, November 2020

Author

BECOSS Study Group, Theuring, Stefanie, Thielecke, Marlene, Loon, Welmoed van, Hommes, Franziska, Hülso, Claudia, Haar, Annkathrin von der, Körner, Jennifer, Schmidt, Michael, Böhringer, Falko, Mall, Marcus A., Rosen, Alexander, Kalle, Christof von, Kirchberger, Valerie Sara, Kurth, Tobias, Seybold, Joachim, Mockenhaupt, Frank Peter, BECOSS Study Group, Theuring, Stefanie, Thielecke, Marlene, Loon, Welmoed van, Hommes, Franziska, Hülso, Claudia, Haar, Annkathrin von der, Körner, Jennifer, Schmidt, Michael, Böhringer, Falko, Mall, Marcus A., Rosen, Alexander, Kalle, Christof von, Kirchberger, Valerie Sara, Kurth, Tobias, Seybold, Joachim, and Mockenhaupt, Frank Peter

Abstract

Background: School attendance during the COVID-19 pandemic is intensely debated. Aim: In November 2020, we assessed SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes and connected households in Berlin, Germany. Methods: We collected oro-nasopharyngeal swabs and blood samples, examining SARS-CoV-2 infection and IgG antibodies by RT-PCR and ELISA. Household members self-swabbed. We assessed individual and institutional prevention measures. Classes with SARS-CoV-2 infection and connected households were retested after 1 week. Results: We examined 1,119 participants, including 177 primary and 175 secondary school students, 142 staff and 625 household members. SARS-CoV-2 infection occurred in eight classes, affecting each 1–2 individuals. Infection prevalence was 2.7% (95% confidence interval (CI): 1.2–5.0; 9/338), 1.4% (95% CI: 0.2–5.1; 2/140), and 2.3% (95% CI: 1.3–3.8; 14/611) among students, staff and household members. Six of nine infected students were asymptomatic at testing. We detected IgG antibodies in 2.0% (95%CI: 0.8–4.1; 7/347), 1.4% (95% CI: 0.2–5.0; 2/141) and 1.4% (95% CI: 0.6–2.7; 8/576). Prevalence increased with inconsistent facemask-use in school, walking to school, and case-contacts outside school. For three of nine households with infection(s), origin in school seemed possible. After 1 week, no school-related secondary infections appeared in affected classes; the attack rate in connected households was 1.1%. Conclusion: School attendance under rigorously implemented preventive measures seems reasonable. Balancing risks and benefits of school closures need to consider possible spill-over infection into households. Deeper insight is required into the infection risks due to being a schoolchild vs attending school.

Published
2021

7. SARS-CoV-2 infection and transmission in school settings during the second wave in Berlin, Germany: a cross-sectional study

Author

BECOSS Study Group, Theuring, Stefanie, Thielecke, Marlene, Loon, Welmoed van, Hommes, Franziska, Hülso, Claudia, Haar, Annkathrin von der, Körner, Jennifer, Schmidt, Michael, Böhringer, Falko, Mall, Marcus A., Rosen, Alexander, Kalle, Christof von, Kirchberger, Valerie Sara, Kurth, Tobias, Seybold, Joachim, Mockenhaupt, Frank Peter, BECOSS Study Group, Theuring, Stefanie, Thielecke, Marlene, Loon, Welmoed van, Hommes, Franziska, Hülso, Claudia, Haar, Annkathrin von der, Körner, Jennifer, Schmidt, Michael, Böhringer, Falko, Mall, Marcus A., Rosen, Alexander, Kalle, Christof von, Kirchberger, Valerie Sara, Kurth, Tobias, Seybold, Joachim, and Mockenhaupt, Frank Peter

Abstract

Background: School attendance during the SARS-CoV-2 pandemic is intensely debated. Modelling studies suggest that school closures contribute to community transmission reduction. However, data among school-attending students and staff are scarce. In November 2020, we examined SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes and connected households in Berlin, Germany. Methods: Students and school staff were examined, oro-nasopharyngeal swabs and blood samples collected, and SARS-CoV-2 infection and IgG antibodies detected by RT-PCR and ELISA. Household members performed self-swabs. Individual and institutional infection prevention and control measures were assessed. Classes with SARS-CoV-2 infection and connected household members were re-tested after one week. Findings: 1119 participants were examined, including 177 primary and 175 secondary school students, 142 staff, and 625 household members. Participants reported mainly cold symptoms (19·4%). SARS-CoV-2 infection occurred in eight of 24 classes affecting each 1-2 individuals. Infection prevalence was 2·7% (95%CI; 1·2-5·0%; 9/338), 1·4% (0·2-5·1%; 2/140), and 2·3% (1·3-3·8%; 14/611) among students, staff and household members, respectively, including quarantined persons. Six of nine infected students were asymptomatic. Prevalence increased with inconsistent facemask use in school, way to school on foot, and case-contacts outside school. IgG antibodies were detected in 2·0% (0·8-4·1%; 7/347), 1·4% (0·2-5·0%; 2/141) and 1·4% (0·6-2·7%; 8/576), respectively. For three of nine households with infection(s) detected at cross-sectional assessment, origin in school seemed possible. After one week, no school-related, secondary infections appeared in affected classes; the attack rate in connected households was 1·1%. Interpretation: These data suggest that school attendance under preventive measures is feasible, provided their rigorous implementation. In balancing threats and benefits of open

Published
2021

8. Accuracy of a Novel SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Test from Standardized Self-Collected Anterior Nasal Swabs

Author

Osmanodja, Bilgin, primary, Budde, Klemens, additional, Zickler, Daniel, additional, Naik, Marcel G., additional, Hofmann, Jörg, additional, Gertler, Maximilian, additional, Hülso, Claudia, additional, Rössig, Heike, additional, Horn, Philipp, additional, Seybold, Joachim, additional, Lunow, Stephanie, additional, Bothmann, Melanie, additional, Barrera-Pesek, Astrid, additional, and Mayrdorfer, Manuel, additional

Published
2021
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9. Diagnostic accuracy of a novel SARS-CoV-2 antigen-detecting rapid diagnostic test from standardized self-collected anterior nasal swabs

Author

Osmanodja, Bilgin, primary, Budde, Klemens, additional, Zickler, Daniel, additional, Naik, Marcel G., additional, Hofmann, Jörg, additional, Gertler, Maximilian, additional, Hülso, Claudia, additional, Rössig, Heike, additional, Horn, Philipp, additional, Seybold, Joachim, additional, Lunow, Stephanie, additional, Bothmann, Melanie, additional, Barrera-Pesek, Astrid, additional, and Mayrdorfer, Manuel, additional

Published
2021
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10. Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected nasalversusnasopharyngeal swab

Author

Lindner, Andreas K., primary, Nikolai, Olga, additional, Rohardt, Chiara, additional, Burock, Susen, additional, Hülso, Claudia, additional, Bölke, Alisa, additional, Gertler, Maximilian, additional, Krüger, Lisa J., additional, Gaeddert, Mary, additional, Tobian, Frank, additional, Lainati, Federica, additional, Seybold, Joachim, additional, Jones, Terry C., additional, Hofmann, Jörg, additional, Sacks, Jilian A., additional, Mockenhaupt, Frank P., additional, and Denkinger, Claudia M., additional

Published
2021
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11. Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected nasal versus nasopharyngeal swab

Author

Lindner, Andreas K., primary, Nikolai, Olga, additional, Rohardt, Chiara, additional, Burock, Susen, additional, Hülso, Claudia, additional, Bölke, Alisa, additional, Gertler, Maximilian, additional, Krüger, Lisa J., additional, Gaeddert, Mary, additional, Tobian, Frank, additional, Lainati, Federica, additional, Seybold, Joachim, additional, Jones, Terry C., additional, Hofmann, Jörg, additional, Sacks, Jilian A., additional, Mockenhaupt, Frank P., additional, and Denkinger, Claudia M., additional

Published
2020
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14. Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected nasal versus nasopharyngeal swab.

Author

Lindner AK, Nikolai O, Rohardt C, Burock S, Hülso C, Bölke A, Gertler M, Krüger LJ, Gaeddert M, Tobian F, Lainati F, Seybold J, Jones TC, Hofmann J, Sacks JA, Mockenhaupt FP, and Denkinger CM

Subjects
Diagnostic Tests, Routine, Humans, Nasopharynx, Nose, COVID-19, SARS-CoV-2
Abstract

Competing Interests: Conflict of interest: A.K. Lindner has nothing to disclose. Conflict of interest: O. Nikolai has nothing to disclose. Conflict of interest: C. Rohardt has nothing to disclose. Conflict of interest: S. Burock has nothing to disclose. Conflict of interest: C. Hülso has nothing to disclose. Conflict of interest: A. Bölke has nothing to disclose. Conflict of interest: M. Gertler has nothing to disclose. Conflict of interest: L.J. Krüger has nothing to disclose. Conflict of interest: M. Gaeddert has nothing to disclose. Conflict of interest: F. Tobian has nothing to disclose. Conflict of interest: F. Lainati has nothing to disclose. Conflict of interest: J. Seybold has nothing to disclose. Conflict of interest: T.C. Jones has nothing to disclose. Conflict of interest: J. Hofmann has nothing to disclose. Conflict of interest: J.A. Sacks has nothing to disclose. Conflict of interest: F.P. Mockenhaupt has nothing to disclose. Conflict of interest: C.M. Denkinger has nothing to disclose.

Published
2021
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