176 results on '"Hötzel, Isidro"'
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2. A Pareto-optimal compositional energy-based model for sampling and optimization of protein sequences
3. Structural definition of babesial RAP-1 proteins identifies a novel protein superfamily across Apicomplexa
4. Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease
5. Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
6. Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing
7. Dynamics of heavy chain junctional length biases in antibody repertoires
8. Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies
9. High titer expression of antibodies using linear expression cassettes for early-stage functional screening.
10. Studies of the Structure of Caprine Arthritis-Encephalitis Virus Surface Envelope Glycoprotein
11. Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
12. Molecular basis for negative regulation of the glucagon receptor
13. Deep-Time Structural Evolution of Retroviral and Filoviral Surface Envelope Proteins
14. Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold
15. Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses
16. In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation
17. Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold
18. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease
19. An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins
20. A dual host vector for Fab phage display and expression of native IgG in mammalian cells
21. TNFα and GM-CSF-induced activation of the CAEV promoter is independent of AP-1
22. A strategy for risk mitigation of antibodies with fast clearance
23. Efficient production of antibodies against a mammalian integral membrane protein by phage display
24. Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein
25. Seven new ovine progressive pneumonia virus (OPPV) field isolates from Dubois Idaho sheep comprise part of OPPV clade II based on surface envelope glycoprotein (SU) sequences
26. Barcoded sequencing workflow for high throughput digitization of hybridoma antibody variable domain sequences
27. Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locus
28. Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires
29. Heavy Chain CDR 3 and Junctional Length Biases in Human Antibody Repertoires Associated with Heavy and Light Chain Germline Utilization
30. Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies
31. Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies
32. Differential Receptor Usage of Small Ruminant Lentiviruses in Ovine and Caprine Cells: Host Range but not Cytopathic Phenotype Is Determined by Receptor Usage
33. Rapid evolution of two discrete regions of the caprine arthritis-encephalitis virus envelope surface glycoprotein during persistent infection
34. Plasmid DNA encoding caprine interferon gamma inhibits antibody response to caprine arthritis-encephalitis virus (CAEV) surface protein encoded by a co-administered plasmid expressing CAEV env and tat genes
35. Sequence similarity between the envelope surface unit (SU) glycoproteins of primate and small ruminant lentiviruses
36. High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
37. Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process
38. Anti-FcRH5/CD3 T Cell Dependent Bispecific Antibody (TDB) for the Treatment of Multiple Myeloma
39. Depletion of major pathogenic cells in asthma by targeting CRTh2
40. The INNs and outs of antibody nonproprietary names
41. Modular protein expression by RNAtrans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector
42. Studies of the Structure of Caprine Arthritis-Encephalitis Virus Surface Envelope Glycoprotein
43. The Artiodactyl APOBEC3 Innate Immune Repertoire Shows Evidence for a Multi-Functional Domain Organization that Existed in the Ancestor of Placental Mammals
44. An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins
45. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals
46. The INNs and outs of antibody nonproprietary names.
47. Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector.
48. Surface Envelope Glycoprotein Is B-Lymphocyte Immunodominant in Sheep Naturally Infected with Ovine Progressive Pneumonia Virus
49. Caprine Arthritis-Encephalitis Virus Envelope Surface Glycoprotein Regions Interacting with the Transmembrane Glycoprotein: Structural and Functional Parallels with Human Immunodeficiency Virus Type 1 gp120
50. Conservation of the Human Immunodeficiency Virus Type 1 gp120 V1/V2 Stem/Loop Structure in the Equine Infectious Anemia Virus (EIAV) gp90
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