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This dataset contains the data presented in the Figures of the paperA heterogeneously integrated lithium niobate-on-silicon nitride photonic platform

Zusammenfassung Ziel der Studie Das Ziel dieser Studie war es, die Schmerzprävalenz, das Ausmaß der Schmerzmitteleinnahme sowie die mentale Gesundheit bei Intensivpflegenden zu untersuchen. Methoden Bei dieser Studie handelte es sich um eine Befragung von Intensivpflegenden aus Deutschland. Neben selbstentwickelten Items wurde die Kurzversion der Depressions-Angst-Stress-Skala (DASS-21) abgefragt. Ergebnisse Insgesamt wurden 432 Intensivpflegende (82,87 % Frauen) in die Analyse eingeschlossen. 36,81 % (95 %-Konfidenzintervall [95 %-KI] 31,31 %; 42,99 %) der Teilnehmenden gaben an, unter wiederkehrenden Schmerzen zu leiden, und 18,52 % (95 %-KI 14,68 %; 23,05 %) gaben an, unter chronischen Schmerzen zu leiden. Signifikant mit chronischen Schmerzen assoziiert waren das Körpergewicht (adjustierte Odds Ratio [AOR]: 1,02 [95 %-KI 1,01; 1,03]; p = 0,006) und das Geschlecht (Männer AOR: 0,33 [95 %-KI 0,14; 0,78]; p = 0,012) sowie mit wiederkehrenden Schmerzen das Geschlecht (Männer AOR: 0,59 [95 %-KI 0,31; 1,00]; p = 0,049) und das Vorliegen von Schlafproblemen (AOR: 2,16 [95 %-KI 1,41; 3,31]; p ≤ 0,001). Schmerzmittel wurden von 52,61 % der Studienteilnehmenden mit chronischen/wiederkehrenden Schmerzen eingenommen (häufigster Wirkstoff: Ibuprofen [81,67 %]). Teilnehmende mit chronischen wie auch wiederkehrenden Schmerzen zeigten signifikant höhere Depressions‑, Angst- und Stresslevel im Vergleich zu denen ohne Schmerzen. Schlussfolgerung Diese Studie zeigt, dass ein großer Anteil der teilnehmenden Intensivpflegekräfte unter chronischen und wiederkehrenden Schmerzen leidet und diese mit verschiedenen Faktoren assoziiert sind.

Core self-evaluation summarizes a decision maker’s self-worth. This key personality trait has been shown to lead to extreme performance consequences of either winning or losing big. We suggest that these extreme performance outcomes may partly rest in how core self-evaluation affects executive’s perception and evaluation of risk in choices under uncertainty. We conducted a choice experiment building on the original prospect theory experiments with 97 executives, in which we measured the effect of core self-evaluation on risk behavior. As a robustness test, we replicated and validated our findings with a larger sample of 111 executives. Building on the tenets of prospect theory, we show that decision makers with high levels of core self-evaluation are less loss averse. Surprisingly, this effect differs depending on whether gains or losses are highlighted in the decision. For gains, higher levels of core self-evaluation are associated with behaviors that are closer to risk neutrality. For losses, however, we find that higher levels of core self-evaluation further enhance the risk-seeking behavior of decision makers. These findings contribute towards understanding the effects of core self-evaluation in the work environment as well as in the decision process and provide an additional lens for studying how the personality of executives affects choices under uncertainty.

We demonstrate an electro-optically tunable hybrid integrated laser self-injection locked to a mode of a heterogeneously integrated lithium-niobate-on-Damascene-silicon-nitride microresonator. An intrinsic linewidth of 3 kHz and a frequency tuning rate of 12 × 1015 Hz/s were observed. Proof-of-principle coherent LiDAR experiments were performed.

We demonstrate a hybrid LiNbO3-Si3N4 photonic integrated platform with propagation loss of 8.5 dB/m at wafer scale. The platform low insertion loss (4 dB) and precise lithographic control. We also demonstrate a number of applications of the platform.

Intensive care nurses have irregular and unusual working hours due to shift work, which can disrupt the natural light-dark rhythm and thus increase the risk for sleep disorders.The aim of this post hoc analysis was to investigate the prevalence of self-reported sleep problems and associated factors among intensive care nurses working in Germany.This analysis was a post hoc analysis of a cross-sectional study, which was performed as an online survey. Collected data were sociodemographic, work-related and health-related data. These data were used to calculate the prevalence and respective 95% confidence intervals (95% CI) of sleep problems. Factors associated with sleep problems were identified using the χThe link to the online survey was accessed 1163 times and 490 intensive care nurses participated in the survey. A total of 432 intensive care nurses were included in this analysis, of whom 82.87% were women. A total of 57.64% (95% CI: 52.83-62.35%) reported sleep problems. Significantly associated with sleep problems were age (50-59 years odds ratio [OR]: 2.05, 95% CI: 1.00-4.21,Sleep problems were present in one out of every two participating intensive care nurses and in particular mental health was associated with sleep problems.

Allogeneic hematopoietic cell transplantation (HCT) during chemotherapy-induced aplasia may offer long-term survival in acute myeloid leukemia (AML) with otherwise poor prognosis including ELN adverse risk, relapsed or refractory disease. However, the value of residual morphologic disease prior HCT in this context has not been conclusively settled until yet. Therefore, we aimed to investigate variables predicting outcome in this unique setting of sequential conditioning therapy, with a focus on pretreatment morphologic blast count. In contrast to the most popular FLAMSA-RIC protocol, we used a melphalan-based conditioning regimen during aplasia.We retrospectively analyzed data from 173 AML patients who underwent a sequential melphalan-based conditioning therapy between 2003 and 2015 at our centre. All patients participated either in the prospective Phase 2 BRIDGE trial (NCT01295307), the Phase 3 AML2003 study (NCT00180102) or were treated according to this protocol and underwent allogeneic HCT after melphalan-based conditioning in treatment-induced aplasia.Median bone marrow blast count prior to conditioning was 10% (range, 0-96%). Four year probabilities of EFS and OS were 34% (95% CI, 28-43%) and 43% (95% CI, 36-52%), respectively. In multivariate analysis, blast count20% was associated with worse EFS (HR = 1.93;Allogeneic HCT in aplasia with a melphalan-based conditioning regimen has the potential to cure a subset of adverse risk AML patients, even with persistent morphological disease prior HCT. However, a high pre-transplant blast count still indicates patients with a dismal prognosis, especially in the relapsed patient group, for whom post-transplant strategies should be considered to further optimize post HCT outcome.

We demonstrate optical frequency comb generation in hybrid high-Q optical microresonators fabricated using direct wafer bonding of photonic Damascene silicon nitride wafer with thin-film lithium niobate-on-insulator (LNOI). The devices enable direct phase control via Pockels effect.

Gallium phosphide (GaP) is an indirect bandgap semiconductor used widely in solid-state lighting. Despite numerous intriguing optical properties---including large $��^{(2)}$ and $��^{(3)}$ coefficients, a high refractive index ($>3$), and transparency from visible to long-infrared wavelengths ($0.55-11\,��$m)---its application as an integrated photonics material has been little studied. Here we introduce GaP-on-insulator as a platform for nonlinear photonics, exploiting a direct wafer bonding approach to realize integrated waveguides with 1.2 dB/cm loss in the telecommunications C-band (on par with Si-on-insulator). High quality $(Q> 10^5)$, grating-coupled ring resonators are fabricated and studied. Employing a modulation transfer approach, we obtain a direct experimental estimate of the nonlinear index of GaP at telecommunication wavelengths: $n_2=1.2(5)\times 10^{-17}\,\text{m}^2/\text{W}$. We also observe Kerr frequency comb generation in resonators with engineered dispersion. Parametric threshold powers as low as 3 mW are realized, followed by broadband ($>100$ nm) frequency combs with sub-THz spacing, frequency-doubled combs and, in a separate device, efficient Raman lasing. These results signal the emergence of GaP-on-insulator as a novel platform for integrated nonlinear photonics., 13 pages, 10 figures, 1 table; typos corrected, added/fixed references, modified title

Since nurses in general are frequently affected by pain and depressive episodes, the aim of this study was to analyze the prevalence of pain, frequency of analgesic intake and the mental health of intensive care nurses.This study was a survey study of German intensive care nurses and the questionnaire comprised self-developed items and the short version of the Depression Anxiety Stress Scale (DASS-21).A total of 432 intensive care nurses (82.97% female) were included in the analysis. Recurrent pain was reported by 36.81% (95% confidence interval [CI]: 31.31%; 42.99%) of study participants and chronic pain by 18.52% (95% CI: 14.68%; 23.05%). Body weight (adjusted odds ratio (AOR): 1.02 [95% CI: 1.01; 1.03]; p = 0.006) and sex (male AOR: 0.33 [95% CI: 0.14; 0.78]; p = 0.012) were significantly associated with chronic pain, and sex (male AOR: 0.59 [95% CI: 0.31; 1.00]; p = 0.049) and the presence of sleeping problems (AOR: 2.16 [95% CI: 1.41; 3.31]; p ≤ 0.001) with recurrent pain. Analgesics were used by 52.61% of study participants with chronic/recurrent pain (most frequently used substance: ibuprofen [81.67%]). Study participants with chronic and recurrent pain indicated significantly higher depression, anxiety and stress levels compared to those without pain.This study indicates that a large number of participating intensive care nurses are suffering from chronic and recurrent pain. Pain in this population was associated with a variety of factors.ZIEL DER STUDIE: Das Ziel dieser Studie war es, die Schmerzprävalenz, das Ausmaß der Schmerzmitteleinnahme sowie die mentale Gesundheit bei Intensivpflegenden zu untersuchen.Bei dieser Studie handelte es sich um eine Befragung von Intensivpflegenden aus Deutschland. Neben selbstentwickelten Items wurde die Kurzversion der Depressions-Angst-Stress-Skala (DASS-21) abgefragt.Insgesamt wurden 432 Intensivpflegende (82,87 % Frauen) in die Analyse eingeschlossen. 36,81 % (95 %-Konfidenzintervall [95 %-KI] 31,31 %; 42,99 %) der Teilnehmenden gaben an, unter wiederkehrenden Schmerzen zu leiden, und 18,52 % (95 %-KI 14,68 %; 23,05 %) gaben an, unter chronischen Schmerzen zu leiden. Signifikant mit chronischen Schmerzen assoziiert waren das Körpergewicht (adjustierte Odds Ratio [AOR]: 1,02 [95 %-KI 1,01; 1,03]; p = 0,006) und das Geschlecht (Männer AOR: 0,33 [95 %-KI 0,14; 0,78]; p = 0,012) sowie mit wiederkehrenden Schmerzen das Geschlecht (Männer AOR: 0,59 [95 %-KI 0,31; 1,00]; p = 0,049) und das Vorliegen von Schlafproblemen (AOR: 2,16 [95 %-KI 1,41; 3,31]; p ≤ 0,001). Schmerzmittel wurden von 52,61 % der Studienteilnehmenden mit chronischen/wiederkehrenden Schmerzen eingenommen (häufigster Wirkstoff: Ibuprofen [81,67 %]). Teilnehmende mit chronischen wie auch wiederkehrenden Schmerzen zeigten signifikant höhere Depressions‑, Angst- und Stresslevel im Vergleich zu denen ohne Schmerzen.Diese Studie zeigt, dass ein großer Anteil der teilnehmenden Intensivpflegekräfte unter chronischen und wiederkehrenden Schmerzen leidet und diese mit verschiedenen Faktoren assoziiert sind.

Quantum computing is one of the great scientific challenges of the 21st century. Small-scale systems today promise to surpass classical computers in the coming years and to enable the solution of classically intractable computational tasks in the fields of quantum chemistry, optimization, cryptography and more. In contrast to classical computers, quantum computers based on superconducting quantum bits (qubits) can to date not be linked over long distance in a network to improve their computing capacity, since devices, which preserve the quantumstate when it is transferred from one machine to another, are not available. Several approaches are being pursued to realize such a component, one of themost promising to date makes use of an intermediary, micromechanical element that enables quantum coherent conversion between the information present in the quantum computer and an optical fiber, without compromising the quantum nature of the information, via optomechanical interaction. This approach could allow fiber-optic quantum networks between separate quantum computers based on superconducting qubits in the future. In this work a platformfor such a microwave-to-optic link was developed based on the piezoelectric material gallium phosphide. This III-V semiconductor offers not only a piezoelectric coupling between the electric field of a microwave circuit and a mechanicalmode, but also a wide optical bandgap E_g = 2.26eV which reduces nonlinear optical absorption in the device and a large refractive index n(1550nm) = 3.01 which allows strong optical confinement at near-infrared wavelengths. Importantly and in contrast to other approaches with gallium phosphide, an epitaxially grown, single crystal thin film of the material is integrated directly on a silicon wafer with pre-structured niobium electrodes by direct wafer-bonding. This opens up the possibility of integrating the device design presented here directly with superconducting qubits fabricated with this material system. A microwave-to-optical transducer design was simulated and fabricated in the galliumphosphideon- silicon platform. The device was found to exhibit large vacuum optomechanical coupling rates g0/2 pi ~ 290kHz and a high intrinsic optical quality factor Q >10^5 while at the same time permitting electromechanical coupling to a microwave electrode. Coherent microwave-tooptical transductionwas shown at room temperature for this device and the electromechanical coupling rate could be extracted from a model derived by input-output theory. The electromechanical coupling between the electro-optomechanical device and a superconducting qubit was estimated to be g/2 pi = O(200kHz) which indicates that strong coupling between the here presented device and a superconducting transmon qubit is achievable. In addition, superconducting microwave cavities with high quality factor at single photon energy Q ~ 5x10^5 were fabricated and measured to verify that fabrication process of the microwave-to-optical transducer is compatible with high-quality superconducting microwave circuits.

Early works1 and recent advances in thin-film lithium niobate (LiNbO3) on insulator have enabled low-loss photonic integrated circuits2,3, modulators with improved half-wave voltage4,5, electro-optic frequency combs6 and on-chip electro-optic devices, with applications ranging from microwave photonics to microwave-to-optical quantum interfaces7. Although recent advances have demonstrated tunable integrated lasers based on LiNbO3 (refs. 8,9), the full potential of this platform to demonstrate frequency-agile, narrow-linewidth integrated lasers has not been achieved. Here we report such a laser with a fast tuning rate based on a hybrid silicon nitride (Si3N4)-LiNbO3 photonic platform and demonstrate its use for coherent laser ranging. Our platform is based on heterogeneous integration of ultralow-loss Si3N4 photonic integrated circuits with thin-film LiNbO3 through direct bonding at the wafer level, in contrast to previously demonstrated chiplet-level integration10, featuring low propagation loss of 8.5 decibels per metre, enabling narrow-linewidth lasing (intrinsic linewidth of 3 kilohertz) by self-injection locking to a laser diode. The hybrid mode of the resonator allows electro-optic laser frequency tuning at a speed of 12 × 1015 hertz per second with high linearity and low hysteresis while retaining the narrow linewidth. Using a hybrid integrated laser, we perform a proof-of-concept coherent optical ranging (FMCW LiDAR) experiment. Endowing Si3N4 photonic integrated circuits with LiNbO3 creates a platform that combines the individual advantages of thin-film LiNbO3 with those of Si3N4, which show precise lithographic control, mature manufacturing and ultralow loss11,12., Nature, 615 (7952), ISSN:0028-0836, ISSN:1476-4687