1. BLADDER CANCER COURSE, FOUR GENETIC HIGH-RISK VARIANTS, AND HISTOPATHOLOGICAL FINDINGS.
- Author
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Kadhum, Thura, Selinski, Silvia, Blaszkewicz, Meinolf, Reinders, Jörg, Roth, Emanuel, Volkert, Frank, Ovsiannikov, Daniel, Moormann, Oliver, Gerullis, Holger, Barski, Dimitri, Otto, Thomas, Höhne, Svetlana, Hengstler, Jan G., and Golka, Klaus
- Subjects
NON-muscle invasive bladder cancer ,BLADDER cancer ,GENETIC variation ,GENOME-wide association studies ,SINGLE nucleotide polymorphisms - Abstract
Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A). This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. The distribution of the 4 SNPs does not vary significantly between cases and controls in the entire study group and in the 3 local subgroups, including two former highly industrialized areas and a region without such history. Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do not noticeably contribute differently to the bladder cancer risk for the bladder cancer subgroups of MIBC and NMIBC. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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