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24 results on '"Hérault, Josiane"'

3. Comparison of two Phaeodactylum tricornutum ecotypes under nitrogen starvation and resupply reveals distinct lipid accumulation strategies but a common degradation process

Author

Murison, Victor, primary, Hérault, Josiane, additional, Côme, Martine, additional, Guinio, Sabrina, additional, Lebon, Alexis, additional, Chamot, Christophe, additional, Bénard, Magalie, additional, Galas, Ludovic, additional, Schoefs, Benoît, additional, Marchand, Justine, additional, Bardor, Muriel, additional, and Ulmann, Lionel, additional

Published
2023
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7. Lipase-catalyzed production of lysophospholipids

Author

Mnasri Taha, Hérault Josiane, Gauvry Laurent, Loiseau Céline, Poisson Laurent, Ergan Françoise, and Pencréac'h Gaëlle

Subjects
lipase, lysophospholipid, hydrolysis, esterification, docosahexaenoic acid, Oils, fats, and waxes, TP670-699
Abstract

Lysophospholipids, such as lysophosphatidic acid or lysophosphatidylcholine, are important bioactive lipids, involved in various normal and pathological cellular processes. They also have industrial and pharmaceutical uses such as emulsifiers or components of drug delivery systems. Lipases, which natural substrates are long chain triacylglycerols, are important biocatalysts for organic synthesis mainly due to their broad substrate specificity and their ability to display high catalytic activity in organic media. This paper describes the various lipase-catalyzed reactions implemented for the production of lysophospholipids. They include hydrolysis or alcoholysis of phospholipids and acylation of the glycerophosphoryl moiety. Special emphasis is made on our work dealing with the production of lysophospholipids rich in dososahexaenoic acid, an important dietary polyunsaturated fatty acid via the hydrolysis of phospholipids extracted from the microalga Isochrysis galbana.

Published
2017
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8. Lipids and lipolytic enzymes of the microalga Isochrysis galbana

Author

Hubert Florence, Poisson Laurent, Loiseau Céline, Gauvry Laurent, Pencréac'h Gaëlle, Hérault Josiane, and Ergan Françoise

Subjects
microalgae, ω-3 polyunsaturated fatty acids, phospholipids, lipolytic enzymes, Oils, fats, and waxes, TP670-699
Abstract

Marine microalgae are now well-known for their ability to produce omega-3 long chain polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Among these microalgae, Isochrysis galbana has received increasing interest especially because of its high DHA content and its common use in hatchery to feed fish larvae and clams. Moreover, lipolysis occurring from the biomass harvest stage suggests that I. galbana may contain lipolytic enzymes with potential interesting selectivities. For these reasons, the potential of this microalga for the production of valuable lipids and lipolytic enzymes was investigated. Lipid analysis revealed that DHA is mainly located at the sn-2 position of the phospholipids. Thus, I. galbana was considered as an interesting starting material for the lipase catalyzed production of 1-lyso-2-DHA-phospholipids which are considered as convenient vehicles for the conveyance of DHA to the brain. Lipids from I. galbana can also be used for the enzyme-catalyzed production of structured phospholipids containing one DHA and one medium chain fatty acid in order to combine interesting therapeutic and biological benefits. Starting from total RNA extract from I. galbana, coding sequences of putative lipolytic enzymes were obtained by RACE and Nested PCR. The heterologous expression of a sequence designated IgTeCe was implemented. An expression plasmid was constructed by ligating the coding sequence to a plasmid vector and then cloned and expressed in E. coli. Results showed the effective functionality of plasmid construction for the production of a recombinant protein with the expected molecular mass. Moreover, local alignment using BLASTP and biochemical evidences support the hypothesis that the expressed protein is a thioesterase.

Published
2017
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14. Diatom Milking: A Review and New Approaches

Author

Vinayak, Vandana, primary, Manoylov, Kalina, additional, Gateau, Hélène, additional, Blanckaert, Vincent, additional, Hérault, Josiane, additional, Pencréac'h, Gaëlle, additional, Marchand, Justine, additional, Gordon, Richard, additional, and Schoefs, Benoît, additional

Published
2015
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16. CATECHOLAMINERGIC METABOLISM AND AUTISM

Author

Martin'eau, Joëlle, primary, Hérault, Josiane, additional, Petit, Elisabeth, additional, Guérin, Pascaline, additional, Hameury, Laurence, additional, Perrot, Anne, additional, Mallet, Jacques, additional, Sauvage, Dominique, additional, Lelord, Gilbert, additional, and Müh, Jean-Pierre, additional

Published
2008
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18. X chromosome and infantile autism

Author

Petit, Elisabeth, primary, Hérault, Josiane, additional, Raynaud, Martine, additional, Cherpi, Catherine, additional, Perrot, Anne, additional, Barthélémy, Catherine, additional, Lelord, Gilbert, additional, and Müh, Jean-Pierre, additional

Published
1996
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21. Possible association of c-harvey-ras-1 (HRAS-1) marker with autism

Author

Hérault, Josiane, primary, Perrot, Anne, additional, Barthélémy, Catherine, additional, Büchler, Matthias, additional, Cherpi, Catherine, additional, Leboyer, Marion, additional, Sauvage, Dominique, additional, Lelord, Gilbert, additional, Mallet, Jacques, additional, and Müh, Jean-Pierre, additional

Published
1993
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22. Catecholaminergic metabolism and autism.

Author

Martin'eau, Joëlle, Hérault, Josiane, Petit, Elisabeth, Guérin, Pascaline, Hameury, Laurence, Perrot, Anne, Mallet, Jacques, Sauvage, Dominique, Lelord, Gilbert, Müh, Jean-Pierre, Martineau, J, Hérault, J, Petit, E, Guérin, P, Hameury, L, Perrot, A, Mallet, J, Sauvage, D, Lelord, G, and Müh, J P

Published
1994
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