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18 results on '"Hémon, Patrice"'

4. Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice

Author

Robert, Olivier, Boujedidi, Hédia, Bigorgne, Amélie, Ferrere, Gladys, Voican, Cosmin Sebastian, Vettorazzi, Sabine, Tuckermann, Jan Peter, Bouchet-Delbos, Laurence, Tran, Thi, Hemon, Patrice, Puchois, Virginie, Dagher, Ibrahim, Douard, Richard, Gaudin, Francoise, Gary-Gouy, Hélène, Capel, Francis, Durand-Gasselin, Ingrid, Prévot, Sophie, Rousset, Sophie, Naveau, Sylvie, Godot, Véronique, Emilie, Dominique, Lombès, Marc, Perlemuter, Gabriel, and Cassard, Anne-Marie

Published
2016
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8. Memory CD4+ T-Cell Lymphocytic Angiopathy in Fatal Forms of COVID-19 Pulmonary Infection

Author

Guihot, Amélie, primary, Plu, Isabelle, additional, Soulié, Cathia, additional, Rousseau, Alice, additional, Nakid-Cordero, Cecilia, additional, Dorgham, Karim, additional, Parizot, Christophe, additional, Litvinova, Elena, additional, Mayaux, Julien, additional, Malet, Isabelle, additional, Quentric, Paul, additional, Combadière, Béhazine, additional, Combadière, Christophe, additional, Bonduelle, Olivia, additional, Adam, Lucille, additional, Rosenbaum, Pierre, additional, Beurton, Alexandra, additional, Hémon, Patrice, additional, Debré, Patrice, additional, Vieillard, Vincent, additional, Autran, Brigitte, additional, Seilhean, Danielle, additional, Charlotte, Frédéric, additional, Marcelin, Anne-Geneviève, additional, Gorochov, Guy, additional, and Luyt, Charles-Edouard, additional

Published
2022
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11. IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiation

Author

Boudigou, Marina, primary, Michée-Cospolite, Magalie, additional, Hémon, Patrice, additional, Grasseau, Alexis, additional, Dantec, Christelle Le, additional, Porchet, Emmanuelle, additional, Jamin, Christophe, additional, Devauchelle, Valérie, additional, Mignen, Olivier, additional, Cornec, Divi, additional, Pers, Jacques-Olivier, additional, Pottier, Laëtitia Le, additional, and Hillion, Sophie, additional

Published
2021
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12. Dual Response to IL-21 and IFN-Alpha Reveals Human B-Cell Precursors With Multiple Differentiation Potentials

Author

Boudigou, Marina, primary, Michée-Cospolite, Magalie, additional, Hémon, Patrice, additional, Grasseau, Alexis, additional, Le Dantec, Christelle, additional, Porchet, Emanuelle, additional, Jamin, Christophe, additional, Devauchelle, Valérie, additional, Mignen, Olivier, additional, Cornec, Divi, additional, Pers, Jacques-Olivier, additional, Le Pottier, Laetitia, additional, and Hillion, Sophie, additional

Published
2021
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13. Etude de la nature moléculaire et des rôles de l'entrée constitutive de calcium dans le cancer du pancreas

Author

Buscaglia, Paul, Debant, Marjolaine, Hémon, Patrice, Philippe, Réginald, Le Goux, Nelig, Mignen, Olivier, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), LabEX IGO Immunothérapie Grand Ouest, Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

15. Dysregulated Lymphoid Cell Populations in Mouse Models of Systemic Lupus Erythematosus.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, De Groof, Aurélie, Hémon, Patrice, Mignen, Olivier, Pers, Jacques-Olivier, Wakeland, Edward K, Renaudineau, Yves, Lauwerys, Bernard, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, De Groof, Aurélie, Hémon, Patrice, Mignen, Olivier, Pers, Jacques-Olivier, Wakeland, Edward K, Renaudineau, Yves, and Lauwerys, Bernard

Abstract

Biases in the distribution and phenotype of T, B, and antigen-presenting cell populations are strongly connected to mechanisms of disease development in mouse models of systemic lupus erythematosus (SLE). Here, we describe longitudinal changes in lymphoid and antigen-presenting cell subsets in bone marrow, blood and spleen from two lupus-prone strains (MRL/lpr and B6.Sle1.Sle2.Sle3 tri-congenic mice), and how they integrate in our present understanding of the pathogenesis of the disease. In particular, we focus on (autoreactive) T cell activation patterns in lupus-prone mice. Break of T cell tolerance to chromatin constituents (histone peptides) is key to the development of the disease and is related to T cell intrinsic defects, contributed by genetic susceptibility factors and by extrinsic amplificatory mechanisms, in particular over-stimulation by antigen-presenting cells. We also describe shifts in B cell sub-populations, going from skewed immature B cell populations as an indication of disturbed central and peripheral tolerance checkpoints, to enriched long-lived plasma cells, which are key to persistent autoantibody production in the disease. B cell activation mechanisms in SLE are both T cell-dependent (break of tolerance and production of specific autoantibodies) and -independent (polyclonal B cell activation, production of autoantibodies by long-lived plasma cells). By providing a comprehensive evaluation of B and T cell surface markers in two major mouse models of SLE and a description of their changes before and after disease onset, this review illustrates how the study of lymphoid cell phenotype delivers key information regarding pathogenic pathways and supplies tools to assess the beneficial effects of novel therapeutic interventions.

Published
2017

18. Imaging Mass Cytometry to Decipher the Maturation of Tertiary Lymphoid Structures.

Author

Le Rochais M, Ghamry-Barrin S, Panouillot M, Hémon P, and Garaud S

Subjects
Humans, Paraffin Embedding methods, Tertiary Lymphoid Structures immunology, Tertiary Lymphoid Structures pathology, Tertiary Lymphoid Structures metabolism, Image Cytometry methods, Colorectal Neoplasms pathology, Colorectal Neoplasms immunology, Colorectal Neoplasms metabolism
Abstract

In the realm of inflammation, including conditions like cancers, infections, and autoimmune diseases, the emergence of tertiary lymphoid structures (TLS) holds significant implications for prognosis and treatment response. Yet, traditional methodologies such as immunohistochemistry and immunofluorescence falter in capturing the nuanced complexities of TLS, necessitating innovative approaches, like imaging mass cytometry (IMC), to unravel their significance. With the capacity to concurrently assess nearly 40 markers within the same tissue section, IMC transcends the constraints of traditional approaches.This chapter delineates the IMC methodology tailored for TLS visualization and subsequent quantification. By leveraging IMC on formalin-fixed, paraffin-embedded (FFPE) sections of human colorectal cancer (CRC) tissues, we aim to establish a standardized protocol that elucidates the intricacies of TLS dynamics and composition., (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2025
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