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803 results on '"Häring, H‐U."'

2. Typ-2-Diabetes

Author

Ammon, H. P. T., Burchard, A., Drexel, H., Füchtenbusch, M., Häring, H.-U., Hauner, H., Joost, H.-G., Matthaei, S., Merkel, M., Müller-Wieland, D., Pfohl, M., Roden, M., Rustenbeck, I., Säly, C., Schatz, H., Schifferdecker, E., Schinner, S., Schwarz, P., Szendrödi, J., Vonbank, A., Wascher, T., Zeyfang, A., Schatz, Helmut, editor, and Pfeiffer, Andreas F. H., editor

Published
2014
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5. Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

Author

Randrianarisoa, E., Lehn-Stefan, A., Hieronimus, A., Wagner, R., Maucher, J., Rittig, K., Balletshofer, B., Birkenfeld, A.L., Peter, A., Stefan, N., Häring, H.-U., Fritsche, A., and Heni, M.

Subjects
Adult, Blood Glucose, Male, Science, Diabetes, Metabolic disorders, Middle Aged, Atherosclerosis, Carotid Intima-Media Thickness, Article, Cardiovascular diseases, Diabetes Mellitus, Type 2, Liver, Humans, Insulin, Medicine, Body Weights and Measures, Female, cardiovascular diseases, Disease Susceptibility, Insulin Resistance, Biomarkers
Abstract

Hyperglycemia and insulin resistance contribute to vascular damage and are regulated by different pathophysiological processes. The aim of the study was to systematically investigate the relative contributions of multiple fasting state- and oral glucose tolerance test (oGTT)-derived glycemic traits to carotid intima-media thickness (cIMT), a surrogate parameter of subclinical atherosclerosis, in individuals with increased risk for type 2 diabetes mellitus (T2D). 667 volunteers (417 women and 250 men, mean age 44.1years), who were free of cardiovascular disease (CVD), were included in this cross-sectional study. Glucose tolerance, insulin sensitivity, insulin secretion and insulin clearance were assessed by frequently sampled 75g oGTT. CIMT was measured by high-resolution ultrasound. Insulin clearance was associated with cIMT in univariate analysis (ßst = −0.17, p < 0.0001) and in a stepwise regression analysis on 15 variables possibly affecting cIMT, age (r2 = 0.3923, p < 0.0001), insulin clearance (r2 = 0.4564, p < 0.0001), systolic blood pressure (r2 = 0.4733, p < 0.0001), body mass index (BMI) (r2 = 0.4804, p = 0.002), gender (r2 = 0.4831, p = 0.013), and fasting insulin clearance (r2 = 0.4857, p = 0.030) turned out to be significant determinants of cIMT. In a cross-validated model resulting from this analysis, insulin clearance was found to be an independent determinant of cIMT (ßst = −0.16, p < 0.0001) even after adjusting for traditional CVD risk factors. Reduced insulin clearance may be an early marker of damage on the vasculature, independent of classical CVD risk factors. Reduced insulin clearance should be considered with regard to vascular insulin resistance.

Published
2020

9. Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9)

Author

Stirm, L., Huypens, P., Sass, S., Batra, R., Fritsche, L., Brucker, S., Abele, H., Hennige, A.M., Theis, F.J., Beckers, J., Hrabě de Angelis, M., Fritsche, A., Häring, H.-U., and Staiger, H.

Abstract

This Article contains an error in Table 1 where the mean value and standard deviation of pregnancy week for the "screening group:NGT women" was incorrectly given as 23.0 +/- 9.5. The correct numbers are 26.5 +/- 2.1. Incorrect: (Table presented.) Correct: (Table presented.).

Published
2022

16. Different effects of lifestyle intervention in high- and low-risk prediabetes

Author

Fritsche, A., Wagner, R., Heni, M., Kantartzis, K., Machann, J., Schick, F., Lehmann, R., Peter, A., Dannecker, C., Fritsche, L., Valenta, V., Nawroth, P.P., Kopf, S., Pfeiffer, A.F., Kabisch, S., Dambeck, U., Stumvoll, M., Blüher, M., Birkenfeld, A.L., Schwarz, P., Hauner, H., Clavel, J., Seißler, J., Lechner, A., Müssig, K., Weber, K., Laxy, M., Bornstein, S., Schürmann, A., Roden, M., Hrabě de Angelis, M., Stefan, N., and Häring, H.-U.

Abstract

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested if prediabetic individuals with low risk benefit from conventional LI and individuals with high risk benefit from an intensification of LI in a multi-center randomized controlled intervention over 12 months with 2 years follow up. 1105 prediabetic individuals based on ADA glucose criteria were stratified into a high- and low-risk phenotype, based on previously described thresholds of insulin secretion, insulin sensitivity and liver fat content. Low-risk individuals were randomly assigned to conventional LI according to the DPP protocol or control (1:1), high-risk individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In high-risk individuals, the difference between conventional and intensified LI in post-challenge glucose change was -0.29 mmol/l [CI:-0.54;-0.04], p=0.025. Liver fat (-1.34 percentage points [CI:-2.17;-0.50], p=0.002) and cardiovascular risk (-1.82[CI:-3.13-0.50],p=0.007) underwent larger reductions with intensified than with conventional LI. During a follow up of 3 years, intensified compared to conventional LI had a higher probability to normalize glucose tolerance (p=0.008). In conclusion, it is possible in high-risk individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk-phenotype-based LI may be beneficial for the prevention of diabetes.

Published
2021

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