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2. Time trends of the association of body mass index with mortality in 3.5 million young Swedish adults

Author

Mboya, Innocent B., Fritz, Josef, da Silva, Marisa, Sun, Ming, Wahlström, Jens, Magnusson, Patrik K.E., Sandin, Sven, Yin, Weiyao, Söderberg, Stefan, Pedersen, Nancy L., Lagerros, Ylva Trolle, Nwaru, Bright I., Kankaanranta, Hannu, Chabok, Abbas, Leppert, Jerzy, Backman, Helena, Hedman, Linnea, Isaksson, Karolin, Michaëlsson, Karl, Häggström, Christel, and Stocks, Tanja

Published
2024
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5. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies

Author

Watts, Eleanor L, Perez‐Cornago, Aurora, Appleby, Paul N, Albanes, Demetrius, Ardanaz, Eva, Black, Amanda, Bueno‐de‐Mesquita, H Bas, Chan, June M, Chen, Chu, Chubb, SA Paul, Cook, Michael B, Deschasaux, Mélanie, Donovan, Jenny L, English, Dallas R, Flicker, Leon, Freedman, Neal D, Galan, Pilar, Giles, Graham G, Giovannucci, Edward L, Gunter, Marc J, Habel, Laurel A, Häggström, Christel, Haiman, Christopher, Hamdy, Freddie C, Hercberg, Serge, Holly, Jeff M, Huang, Jiaqi, Huang, Wen‐Yi, Johansson, Mattias, Kaaks, Rudolf, Kubo, Tatsuhiko, Lane, J Athene, Layne, Tracy M, Le Marchand, Loic, Martin, Richard M, Metter, E Jeffrey, Mikami, Kazuya, Milne, Roger L, Morris, Howard A, Mucci, Lorelei A, Neal, David E, Neuhouser, Marian L, Oliver, Steven E, Overvad, Kim, Ozasa, Kotaro, Pala, Valeria, Pernar, Claire H, Pollak, Michael, Rowlands, Mari‐Anne, Schaefer, Catherine A, Schenk, Jeannette M, Stattin, Pär, Tamakoshi, Akiko, Thysell, Elin, Touvier, Mathilde, Trichopoulou, Antonia, Tsilidis, Konstantinos K, Van Den Eeden, Stephen K, Weinstein, Stephanie J, Wilkens, Lynne, Yeap, Bu B, Key, Timothy J, Allen, Naomi E, and Travis, Ruth C

Subjects
Cancer, Aging, Urologic Diseases, Adult, Aged, Aged, 80 and over, Anthropometry, Biomarkers, Tumor, Cross-Sectional Studies, Humans, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male, Middle Aged, Neoplasms, Prospective Studies, Young Adult, IGFs, IGFBPs, pooled analysis, correlates, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

Published
2019

7. Cumulative incidence of and risk factors for BCG infection after adjuvant BCG instillations.

Author

Holmberg, Lars, Skogmar, Sten, Garmo, Hans, Hagberg, Oskar, Häggström, Christel, Gårdmark, Truls, Ströck, Viveka, Aljabery, Firas, Jahnson, Staffan, Hosseini, Abolfazl, Jerlström, Tomas, Sherif, Amir, Söderkvist, Karin, Ullén, Anders, Malmström, Per‐Uno, and Liedberg, Fredrik

Subjects
BLADDER cancer, INTRAVESICAL administration, BCG immunotherapy, TRANSURETHRAL resection of bladder, NON-muscle invasive bladder cancer, DRUGS
Abstract

Objectives: To investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette‐Guérin (BCG) infections after adjuvant BCG instillations in patients with non‐muscle‐invasive bladder cancer (NMIBC). Patients and Methods: We analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nationwide database 'BladderBaSe 2.0'. The cumulative incidence proportion of a BCG infection was indicated by a reported diagnosis of tuberculosis (TB) in the patient registry or filing a prescription for tuberculostatic drugs. Results: The cumulative incidence proportion was 1.1% at the 5‐year follow‐up in 5033 patients exposed to adjuvant BCG instillations. The incidence rate was highest during the first 2 years after start of BCG instillations. Women had a lower risk than men (hazard ratio 0.23, 95% confidence interval 0.07–0.74). Age and calendar time at diagnosis, comorbidity, tumour risk group, previous medication with corticosteroids, immunosuppressive drugs, or time between transurethral resection of the bladder tumour and commencing the adjuvant BCG instillation were not associated with risk. Conclusions: These data further supports that the overall risk of a BCG infection after BCG‐instillation treatment for NMIBC is low. The great majority of infections occur in the first 2 years, calling for an awareness of the diverse symptoms of BCG infection during this period. We provide evidence for male sex as a risk factor; however, the statistical precision is low and with a risk of selection bias, making it difficult to rule out the other suggested risk factors without further studies with different approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Body Mass Index and Risk of Over 100 Cancer Forms and Subtypes in 4·1 Million Individuals in Sweden: The Obesity and Disease Development Sweden (ODDS) Pooled Cohort Study

Author

Sun, Ming, primary, Silva, Marisa da, additional, Bjørge, Tone, additional, Fritz, Josef, additional, Mboya, Innocent B., additional, Jerkeman, Mats, additional, Stattin, Pär, additional, Wahlström, Jens, additional, Michaëlsson, Karl, additional, van Guelpen, Bethany, additional, Magnusson, Patrik, additional, Sandin, Sven, additional, Yin, Weiyao, additional, Lagerros, Ylva Trolle, additional, Ye, Weimin, additional, Nwaru, Bright I., additional, Kankaanranta, Hannu, additional, Lönnberg, Lena, additional, Chabok, Abbas, additional, Isaksson, Karolin, additional, Pedersen, Nancy L., additional, Elmståhl, Sölve, additional, Lind, Lars, additional, Hedman, Linnea, additional, Häggström, Christel, additional, and Stocks, Tanja, additional

Published
2024
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14. Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts

Author

Fritz, Josef, primary, Jochems, Sylvia H. J., additional, Bjørge, Tone, additional, Wood, Angela M., additional, Häggström, Christel, additional, Ulmer, Hanno, additional, Nagel, Gabriele, additional, Zitt, Emanuel, additional, Engeland, Anders, additional, Harlid, Sophia, additional, Drake, Isabel, additional, Stattin, Pär, additional, and Stocks, Tanja, additional

Published
2023
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23. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort

Author

Christakoudi, Sofia, Tsilidis, Konstantinos K., Muller, David C., Freisling, Heinz, Weiderpass, Elisabete, Overvad, Kim, Söderberg, Stefan, Häggström, Christel, Pischon, Tobias, Dahm, Christina C., Zhang, Jie, Tjønneland, Anne, Halkjær, Jytte, MacDonald, Conor, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Kaaks, Rudolf, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Cirera, Lluís, Barricarte-Gurrea, Aurelio, Amiano, Pilar, Memarian, Ensieh, Sonestedt, Emily, Bueno-de-Mesquita, Bas, May, Anne M., Khaw, Kay-Tee, Wareham, Nicholas J., Tong, Tammy Y. N., Huybrechts, Inge, Noh, Hwayoung, Aglago, Elom K., Ellingjord-Dale, Merete, Ward, Heather A., Aune, Dagfinn, and Riboli, Elio

Published
2020
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25. Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study.

Author

Sai San Moon Lu, Rutegård, Martin, Ahmed, Maghfoor, Häggström, Christel, Gylfe, Åsa, Harlid, Sophia, and Van Guelpen, Bethany

Abstract

Background: Antibiotics use is associated with higher colorectal cancer risk, but little is known regarding any potential effects on survival. Methods: We conducted a nationwide cohort study, using complete-population data from Swedish national registers between 2005 and 2020, to investigate prediagnostic prescription antibiotics use in relation to survival in colorectal cancer patients. Results: We identified 36,061 stage I-III and 11,242 stage IV colorectal cancer cases diagnosed between 2010 and 2019. For stage I-III, any antibiotics use (binary yes/no variable) was not associated with overall or cancer-specific survival. Compared with no use, moderate antibiotics use (total 11-60 days) was associated with slightly better cancer-specific survival [adjusted HR (aHR) = 0.93; 95% confidence interval (CI), 0.86-0.99)], whereas very high use (>180 days) was associated with worse survival [overall survival (OS) aHR = 1.42; 95% CI, 1.26-1.60, cancer-specific survival aHR = 1.31; 95% CI, 1.10-1.55]. In analyses by different antibiotic types, although not statistically significant, worse survival outcomes were generally observed across several antibiotics, particularly macrolides and/or lincosamides. In stage IV colorectal cancer, inverse relationships between antibiotics use and survival were noted. Conclusions: Overall, our findings do not support any substantial detrimental effects of prediagnostic prescription antibiotics use on cancer-specific survival after colorectal cancer diagnosis, with the possible exception of very high use in stage I-III colorectal cancer. Further investigation is warranted to confirm and understand these results. Impact: Although the study findings require confirmation, physicians probably do not need to factor in prediagnostic prescription antibiotics use in prognosticating patients with colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Preoperative upper tract invasive diagnostic modalities are associated with intravesical recurrence following surgery for upper tract urothelial carcinoma: A population-based study

Author

Liedberg, Fredrik, primary, Hagberg, Oskar, additional, Häggström, Christel, additional, Aljabery, Firas, additional, Gårdmark, Truls, additional, Hosseini, Abolfazl, additional, Jahnson, Staffan, additional, Jerlström, Tomas, additional, Ströck, Viveka, additional, Söderkvist, Karin, additional, Ullén, Anders, additional, Holmberg, Lars, additional, and Bobjer, Johannes, additional

Published
2023
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28. Cohort profile: Bladder Cancer Data Base Sweden (BladderBaSe) 2.0

Author

Häggström, Christel, primary, Hagberg, Oskar, additional, Gårdmark, Truls, additional, Aljabery, Firas, additional, Ströck, Viveka, additional, Hosseini, Abolfazl, additional, Sherif, Amir, additional, Malmstrom, Per-Uno, additional, Söderkvist, Karin, additional, Ullén, Anders, additional, Jerlström, Tomas, additional, Jahnson, Staffan, additional, Liedberg, Fredrik, additional, and Holmberg, Lars, additional

Published
2022
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30. Number of transurethral procedures after non-muscle-invasive bladder cancer and survival in causes other than bladder cancer

Author

Holmberg, Lars, primary, Hagberg, Oskar, additional, Häggström, Christel, additional, Gårdmark, Truls, additional, Ströck, Viveka, additional, Aljabery, Firas, additional, Jahnson, Staffan, additional, Hosseini, Abolfazl, additional, Jerlström, Tomas, additional, Sherif, Amir, additional, Söderkvist, Karin, additional, Ullén, Anders, additional, Enlund, Mats, additional, Liedberg, Fredrik, additional, and Malmström, Per-Uno, additional

Published
2022
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31. Pooled cohort study on height and risk of cancer and cancer death

Author

Wirén, Sara, Häggström, Christel, Ulmer, Hanno, Manjer, Jonas, Bjørge, Tone, Nagel, Gabriele, Johansen, Dorthe, Hallmans, Göran, Engeland, Anders, Concin, Hans, Jonsson, Håkan, Selmer, Randi, Tretli, Steinar, Stocks, Tanja, and Stattin, Pär

Published
2014

36. The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study

Author

Johansson, Mattias, Carreras-Torres, Robert, Scelo, Ghislaine, Purdue, Mark P., Mariosa, Daniela, Muller, David C., Timpson, Nicolas J., Haycock, Philip C., Brown, Kevin M., Wang, Zhaoming, Ye, Yuanqing, Hofmann, Jonathan N., Foll, Matthieu, Gaborieau, Valerie, Machiela, Mitchell J., Colli, Leandro M., Li, Peng, Garnier, Jean-Guillaume, Blanche, Helene, Boland, Anne, Burdette, Laurie, Prokhortchouk, Egor, Skryabin, Konstantin G., Yeager, Meredith, Radojevic-Skodric, Sanja, Ognjanovic, Simona, Foretova, Lenka, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Mukeriya, Anush, Rascu, Stefan, Zaridze, David, Bencko, Vladimir, Cybulski, Cezary, Fabianova, Eleonora, Jinga, Viorel, Lissowska, Jolanta, Lubinski, Jan, Navratilova, Marie, Rudnai, Peter, Benhamou, Simone, Cancel-Tassin, Geraldine, Cussenot, Olivier, Weiderpass, Elisabete, Ljungberg, Börje, Tumkur Sitaram, Raviprakash, Häggström, Christel, Bruinsma, Fiona, Jordan, Susan J., Severi, Gianluca, Winship, Ingrid, Hveem, Kristian, Vatten, Lars J., Fletcher, Tony, Larsson, Susanna C., Wolk, Alicja, Banks, Rosamonde E., Selby, Peter J., Easton, Douglas F., Andreotti, Gabriella, Beane Freeman, Laura E., Koutros, Stella, Männistö, Satu, Weinstein, Stephanie, Clark, Peter E., Edwards, Todd L., Lipworth, Loren, Gapstur, Susan M., Stevens, Victoria L., Carol, Hallie, Freedman, Matthew L., Pomerantz, Mark M., Cho, Eunyoung, Wilson, Kathryn M., Gaziano, J. Michael, Sesso, Howard D., Freedman, Neal D., Parker, Alexander S., Eckel-Passow, Jeanette E., Huang, Wen-Yi, Kahnoski, Richard J., Lane, Brian R., Noyes, Sabrina L., Petillo, David, Teh, Bin Tean, Peters, Ulrike, White, Emily, Anderson, Garnet L., Johnson, Lisa, Luo, Juhua, Buring, Julie, Lee, I-Min, Chow, Wong-Ho, Moore, Lee E., Eisen, Timothy, Henrion, Marc, Larkin, James, Barman, Poulami, Leibovich, Bradley C., Choueiri, Toni K., Lathrop, G. Mark, Deleuze, Jean-Francois, Gunter, Marc, McKay, James D., Wu, Xifeng, Houlston, Richard S., Chanock, Stephen J., Relton, Caroline, Richards, J. Brent, Martin, Richard M., Davey Smith, George, and Brennan, Paul

Subjects
Obesity -- Genetic aspects -- Complications and side effects, Renal cell carcinoma -- Genetic aspects -- Development and progression -- Care and treatment, Genetic markers -- Health aspects, Etiology (Medicine), Genetics, Carcinoma, Cancer, Type 2 diabetes, Genomics, Insulin, Proxy, Lipids, Genomes, Fasting, Glucose, Biological sciences
Abstract

Background Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation. Methods and findings Genetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sample MR framework. The effect on RCC risk was estimated by calculating odds ratios (OR.sub.SD) for a standard deviation (SD) increment in each risk factor. The MR analysis indicated that higher body mass index increases the risk of RCC (OR.sub.SD : 1.56, 95% confidence interval [CI] 1.44-1.70), with comparable results for waist-to-hip ratio (OR.sub.SD : 1.63, 95% CI 1.40-1.90) and body fat percentage (OR.sub.SD : 1.66, 95% CI 1.44-1.90). This analysis further indicated that higher fasting insulin (OR.sub.SD : 1.82, 95% CI 1.30-2.55) and diastolic blood pressure (DBP; OR.sub.SD : 1.28, 95% CI 1.11-1.47), but not systolic blood pressure (OR.sub.SD : 0.98, 95% CI 0.84-1.14), increase the risk for RCC. No association with RCC risk was seen for lipids, overall type 2 diabetes, or fasting glucose. Conclusions This study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk., Author(s): Mattias Johansson 1,*, Robert Carreras-Torres 1, Ghislaine Scelo 1, Mark P. Purdue 2, Daniela Mariosa 1, David C. Muller 3, Nicolas J. Timpson 4, Philip C. Haycock 4, Kevin [...]

Published
2019
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40. Bladder cancer recurrence in papillary urothelial neoplasm of low malignant potential (PUNLMP) compared to G1 WHO 1999: a population-based study

Author

Bobjer, Johannes, primary, Hagberg, Oskar, additional, Aljabery, Firas, additional, Gårdmark, Truls, additional, Jahnson, Staffan, additional, Jerlström, Tomas, additional, Sherif, Amir, additional, Simoulis, Athanasious, additional, Ströck, Viveka, additional, Häggström, Christel, additional, Holmberg, Lars, additional, and Liedberg, Fredrik, additional

Published
2021
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43. Cumulative incidence of ureteroenteric strictures after radical cystectomy in a population-based Swedish cohort

Author

Magnusson, Jenny, primary, Hagberg, Oskar, additional, Aljabery, Firas, additional, Hosseini, Abolfazl, additional, Jahnson, Staffan, additional, Jerlström, Tomas, additional, Sherif, Amir, additional, Söderkvist, Karin, additional, Ströck, Viveka, additional, Ullén, Anders, additional, Häggström, Christel, additional, Holmberg, Lars, additional, and Kjölhede, Henrik, additional

Published
2021
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44. sj-pdf-1-inq-10.1177_00469580211030217 – Supplemental material for Designing a Pragmatic Intervention to Help Improve the Bladder Cancer Patient Experience

Author

Bessa, Agustina, Bosco, Cecilia, Cahill, Fidelma, Russell, Beth, Fox, Louis, Moss, Charlotte, Wylie, Harriet, Haire, Anna, Green, Saran, Enting, Deborah, Khan, Shamim, Nair, Rajesh, Thurairaja, Ramesh, Chatterton, Kathryn, Amery, Suzanne, Peat, Nicola, Smith, Sue, Spear, Stuart, Bryan, Richard T, Frodsham, Leila, Burke, Danny, Rigby, Jeannie, Makaroff, Lydia, Kelly, Phil, Costin, Melanie, Häggström, Christel, and Van Hemelrijck, Mieke

Subjects
111099 Nursing not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-inq-10.1177_00469580211030217 for Designing a Pragmatic Intervention to Help Improve the Bladder Cancer Patient Experience by Agustina Bessa, Cecilia Bosco, Fidelma Cahill, Beth Russell, Louis Fox, Charlotte Moss, Harriet Wylie, Anna Haire, Saran Green, Deborah Enting, Shamim Khan, Rajesh Nair, Ramesh Thurairaja, Kathryn Chatterton, Suzanne Amery, Nicola Peat, Sue Smith, Stuart Spear, Richard T Bryan, Leila Frodsham, Danny Burke, Jeannie Rigby, Lydia Makaroff, Phil Kelly, Melanie Costin, Christel Häggström and Mieke Van Hemelrijck in INQUIRY: The Journal of Health Care Organization, Provision, and Financing

Published
2021
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45. Bladder cancer recurrence in papillary urothelial neoplasm of low malignant potential (PUNLMP) compared to G1 WHO 1999: a population-based study

Author

Bobjer, Johannes, Hagberg, Oskar, Aljabery, Firas, Gårdmark, Truls, Jahnson, Staffan, Jerlström, Tomas, Sherif, Amir, Simoulis, Athanasious, Ströck, Viveka, Häggström, Christel, Holmberg, Lars, and Liedberg, Fredrik

Abstract

Papillary urothelial neoplasm of low malignant potential (PUNLMP) and stage TaG1 non-muscle invasive bladder cancer (NMIBC) represent separate categories in current WHO 1999 grade definitions. Similarly, PUNLMP and Ta low-grade are separate entities in the WHO 2004/2016 grading system. However, this classification is currently questioned by reports showing a similar risk of recurrence and progression for both categories. In this population-based study, risk estimates were evaluated in patients diagnosed with PUNLMP (n = 135) or stage TaG1 (n = 2176) NMIBC 2004–2008 with 5-year follow-up registration in the nation-wide Bladder Cancer Data Base Sweden (BladderBaSe). The risk of recurrence was assessed using multivariable Cox regression with adjustment for multiple confounders (age, gender, marital status, comorbidity, educational level, and health care region). At five years, 28/135 (21%) patients with PUNLMP and 922/2176 (42%) with TaG1 had local recurrence. The corresponding progression rates were 0.7% (1/135) and 4.0% (86/2176), respectively. A higher relative risk of recurrence was detected in patients with TaG1 tumours compared to PUNLMP (Hazard Ratio 1.6, 95% CI 1.2–2.0) at 5-year follow-up, while progression events were too few to compare. The difference in risk of recurrence between primary stage TaG1 and PUNLMP stands in contrast to the recently adapted notion that treatment and follow-up strategies can be merged into one low-risk group of NMIBC.

Published
2021
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47. The Inverse Association of Body Mass Index with Lung Cancer: Exploring Residual Confounding, Metabolic Aberrations and Within-Person Variability in Smoking

Author

Wood, Angela M., primary, Jonsson, Håkan, additional, Nagel, Gabriele, additional, Häggström, Christel, additional, Manjer, Jonas, additional, Ulmer, Hanno, additional, Engeland, Anders, additional, Zitt, Emanuel, additional, Jochems, Sylvia H.J., additional, Ghaderi, Sara, additional, Stattin, Pär, additional, Bjørge, Tone, additional, and Stocks, Tanja, additional

Published
2021
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48. Survival after radical cystectomy during holiday periods

Author

Liedberg, Fredrik, primary, Hagberg, Oskar, additional, Aljabery, Firas, additional, Gårdmark, Truls, additional, Hosseini, Abolfazl, additional, Jahnson, Staffan, additional, Jerlström, Tomas, additional, Malmström, Per-Uno, additional, Sherif, Amir, additional, Söderkvist, Karin, additional, Ströck, Viveka, additional, Ullén, Anders, additional, Häggström, Christel, additional, and Holmberg, Lars, additional

Published
2021
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49. Thromboembolism in Muscle-Invasive Bladder Cancer. A Population-based Nationwide Study

Author

Jahnson, Staffan, primary, Gårdmark, Truls, additional, Hosseini, Abolfazl, additional, Jerlström, Tomas, additional, Liedberg, Fredrik, additional, Malmström, Per-Uno, additional, Hagberg, Oskar, additional, Sherif, Amir, additional, Ströck, Viveka, additional, Söderkvist, Karin, additional, Ullen, Anders, additional, Häggström, Christel, additional, Holmberg, Lars, additional, and Aljabery, Firas, additional

Published
2021
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50. Cumulative incidence of midline incisional hernia and its surgical treatment after radical cystectomy and urinary diversion for bladder cancer: A nation-wide population-based study

Author

Liedberg, Fredrik, Hagberg, Oskar, Aljabery, Firas, Gårdmark, Truls, Jahnson, Staffan, Jerlström, Tomas, Montgomery, Agneta, Sherif, Amir, Ströck, Viveka, Häggström, Christel, and Holmberg, Lars

Subjects
Male, Hernia, Databases, Factual, Epidemiology, Science, Urinary Bladder, Cancer Treatment, Surgical and Invasive Medical Procedures, Robotic Assisted Surgery, Urinary Diversion, Cystectomy, Urinary System Procedures, Postoperative Complications, Signs and Symptoms, Urologi och njurmedicin, Medicine and Health Sciences, Urology and Nephrology, Humans, Incisional Hernia, Aged, Retrospective Studies, Sweden, Carcinoma, Transitional Cell, Surgical Excision, Kirurgi, Incidence, Cancer Risk Factors, Middle Aged, Urinary Bladder Neoplasms, Oncology, Surgical Repair, Medical Risk Factors, Medicine, Surgery, Female, Clinical Medicine, Research Article
Abstract

Background and objective To study the cumulative incidence and surgical treatment of midline incisional hernia (MIH) after cystectomy for bladder cancer. Methods In the nationwide Bladder Cancer Data Base Sweden (BladderBaSe), cystectomy was performed in 5646 individuals. Cumulative incidence MIH and surgery for MIH were investigated in relation to age, gender, comorbidity, previous laparotomy and/or inguinal hernia repair, operative technique, primary/secondary cystectomy, postoperative wound dehiscence, year of surgery, and period-specific mean annual hospital cystectomy volume (PSMAV). Results Three years after cystectomy the cumulative incidence of MIH and surgery for MIH was 8% and 4%, respectively. The cumulative incidence MIH was 12%, 9% and 7% in patients having urinary diversion with continent cutaneous pouch, orthotopic neobladder and ileal conduit. Patients with postoperative wound dehiscence had a higher three-year cumulative incidence MIH (20%) compared to 8% without. The corresponding cumulative incidence surgery for MIH three years after cystectomy was 9%, 6%, and 4% for continent cutaneous, neobladder, and conduit diversion, respectively, and 11% for individuals with postoperative wound dehiscence (vs 4% without). Using multivariable Cox regression, secondary cystectomy (HR 1.3 (1.0-1.7)), continent cutaneous diversion (HR 1.9 (1.1-2.4)), robot-assisted cystectomy (HR 1.8 (1-3.2)), wound dehiscence (HR 3.0 (2.0-4.7)), cystectomy in hospitals with PSMAV 10-25 (HR 1.4 (1.0-1.9)), as well as cystectomy during later years (HRs 2.5-3.1) were all independently associated with increased risk of MIH. Conclusions The cumulative incidence of MIH was 8% three years postoperatively, and increase over time. Avoiding postoperative wound dehiscence after midline closure is important to decrease the risk of MIH. Funding Agencies|Swedish Cancer SocietySwedish Cancer Society [CAN 2019/62, CAN 2017/278]; Lund Medical Faculty (ALF); Skane University Hospital Research Funds; Gyllenstierna Krapperups Foundation; Skane County Councils Research and Development Foundation [REGSKANE-622351]; Gosta Jonsson Research Foundation; Foundation of Urological Research; Hillevi Fries Research Foundation

Published
2020

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