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Egy 72 éves férfi esetét ismertetjük, akit bal orbitára terjedő ismeretlen eredetű, antibiotikumterápiára nem reagáló cellulitis miatt vettünk fel klinikánkra. A szemészeti tünetek 9 nappal a második, inaktivált COVID-19-oltás (VeroCell – China National Pharmaceutical Group Co. Ltd.) beadását követően jelentkeztek, először a szem „vibrálásával”, majd kidülledésével. Kórelőzményből kiemelendő, hogy az első vakcina beadása után két héttel gégeödéma alakult ki a betegnél, amely sürgősségi ellátás keretében intravénás szteroidkezelést igényelt. A fentiek ellenére a második, ugyanolyan vakcina beadását nem tartották kontraindikáltnak. A beteg felvételekor a bal szemen jelentős protrúziót, minden irányban korlátozott szemmozgásokat és kifejezett kötőhártya-chemosist találtunk, ugyanakkor a fül-orr-gégészeti konzílium az orrmelléküreg-eredetű fertőzést kizárta. A korábban megkezdett parenterális antibiotikumterápia hatástalansága miatt a harmadik napon intravénás szteroidterápiát indítottunk, amely után gyors javulást tapasztaltunk, és néhány nappal később a beteget tünetmentesen emittáltuk. A kórelőzményben nem szerepelt COVID-19-fertőzés, és a beteg bennfekvése során többször ismételt antigén gyorsteszt, illetve PCR-teszt sem aktív, sem lezajlott fertőzést nem támasztott alá. Mindezek alapján a leírt szemészeti kórkép nagy valószínűséggel tartható a COVID-19-oltás szövődményének. Tudomásunk szerint eddig a szakirodalom nem írt le orbita cellulitist oltási szövődményként.

Abstract: Sulpha drugs are widely employed in medicine for various diseases and disorders. During the last several decades, numerous papers had been published on supra ciliary and posterior choroidal effusion likely presenting as an idiosyncratic effect of these drugs especially of acetazolamide. In each publication, the effusion was associated with either an acute angle-closure glaucoma or transitory myopia or both of these as leading symptoms. In the current publication, authors report on two cases where the acetazolamide-induced choroidal effusion was an accidental finding without either a myopic shift in refraction or an acute elevation in intraocular pressure. To our best knowledge, ours is the first report in the literature describing this unusual, “silent” form of a sulpha drug-induced choroidal effusion. Since the choroidal involvement may vary in size and location, and is not necessarily associated with acute glaucoma and myopia, one can assume that a considerable amount of acetazolamide-related ocular side-effects will not be discovered. The above case report aims to draw the attention of other specialities to the need for ophthalmic examination for their patients taking sulpha drugs with acute visual deterioration. Orv Hetil. 2017; 158(50): 1998–2002.

Abstract: Measles, caused by the Morbilli virus, is a highly (about 95 %) contagious disease affecting primarily children, but without proper immunisation, adults can also be infected. The leading symptoms of the disease are high fever that presents after an incubation period of 9–10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occurring conjunctivitis, the so-called “red eye symptom”, is not characteristic only for measles infection, however, by taking the generalized symptoms it can suggest the diagnosis at the beginning of the disease. Conjunctivitis of varying severity is noticed in the half of the cases without using ophthalmological instrumentation. Using ophthalmological instrumentation, the mild forms of conjunctivitis can be diagnosed, by meticulous ophthalmological examination, further eye diseases can be discovered. The viral conjunctivitis can progress to keratitis and bacterial superinfection can occur. If the infection presents in childhood it can affect the posterior segment. The fight against measles is very effective in Hungary since the vaccination has been introduced, and the lack of vaccination is also the primary cause of the risk to the disease. In the diagnosis, symptomatic treatment of the disease and the curbing of possible mass infections, the practicing physician (general practitioner) has a key role. The correct care of the infected patient in Hungary is provided by a methodological letter, professional information and legal guides. Orv Hetil. 2017; 158(39): 1523–1527.

Sulpha drugs are widely employed in medicine for various diseases and disorders. During the last several decades, numerous papers had been published on supra ciliary and posterior choroidal effusion likely presenting as an idiosyncratic effect of these drugs especially of acetazolamide. In each publication, the effusion was associated with either an acute angle-closure glaucoma or transitory myopia or both of these as leading symptoms. In the current publication, authors report on two cases where the acetazolamide-induced choroidal effusion was an accidental finding without either a myopic shift in refraction or an acute elevation in intraocular pressure. To our best knowledge, ours is the first report in the literature describing this unusual, "silent" form of a sulpha drug-induced choroidal effusion. Since the choroidal involvement may vary in size and location, and is not necessarily associated with acute glaucoma and myopia, one can assume that a considerable amount of acetazolamide-related ocular side-effects will not be discovered. The above case report aims to draw the attention of other specialities to the need for ophthalmic examination for their patients taking sulpha drugs with acute visual deterioration. Orv Hetil. 2017; 158(50): 1998-2002.

Measles, caused by the Morbilli virus, is a highly (about 95 %) contagious disease affecting primarily children, but without proper immunisation, adults can also be infected. The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occurring conjunctivitis, the so-called "red eye symptom", is not characteristic only for measles infection, however, by taking the generalized symptoms it can suggest the diagnosis at the beginning of the disease. Conjunctivitis of varying severity is noticed in the half of the cases without using ophthalmological instrumentation. Using ophthalmological instrumentation, the mild forms of conjunctivitis can be diagnosed, by meticulous ophthalmological examination, further eye diseases can be discovered. The viral conjunctivitis can progress to keratitis and bacterial superinfection can occur. If the infection presents in childhood it can affect the posterior segment. The fight against measles is very effective in Hungary since the vaccination has been introduced, and the lack of vaccination is also the primary cause of the risk to the disease. In the diagnosis, symptomatic treatment of the disease and the curbing of possible mass infections, the practicing physician (general practitioner) has a key role. The correct care of the infected patient in Hungary is provided by a methodological letter, professional information and legal guides. Orv Hetil. 2017; 158(39): 1523-1527.

Ocular signs and symptoms of Ebola infection initially suggest banal conjunctivitis, but in advanced cases severe haemorrhagic conjunctivitis appears and, in the final stage of the disease, retinal and chorioidal haemorrhages may occur which can cause even blindness. Although the viral infection accompanied by ocular symptoms of a non-specific conjunctivitis, the high fever present from the onset of the disease should raise the suspicion of Ebola infection. There is no causal therapy know so far, and the only adjunctive treatment may be delivered by an ophthalmologist. Because the virus can be detected in the tear, it can theoretically be the mediator of the infection and, therefore, ophthalmological examinations should be carried out with the highest caution. In case of suspected Ebola infection the nearest competent healthcare authority should be immediately alerted in order to take further actions.Az Ebola-fertőzés szemészeti tünetei kezdetben banális kötőhártya-gyulladásként jelentkeznek, előrehaladott állapotban azonban súlyos vérzéses kötőhártya-gyulladás jelenik meg, majd a betegség végső fázisában chorioidealis és retinavérzések léphetnek fel, amelyek vaksággal is járhatnak. A betegség kezdetétől megjelenő magas láz azonban már a betegség kezdeti stádiumában fellépő enyhe nem specifikus kötőhártya-gyulladásos tünetek megjelenésével együtt segít a betegség lehetőségének felvetésében. A betegség kezelésére nincs oki terápia és szemészetileg is csak tüneti kezelést lehet végezni. Mivel a vírus a könnyből is kimutatható, és elvileg fertőzés közvetítője is lehet, a szemészeti vizsgálatokat nagy körültekintéssel kell végezni. Ebola-fertőzés gyanúja esetén haladéktalanul riasztani kell a legközelebbi illetékes egészségügyi hivatalt, hogy a további szükséges intézkedéseket megtegye. Orv. Hetil., 2015, 156(11), 431–433.

To demonstrate a numerical data set for intraoperative pain during phacoemulsification and compare the pain scores for first and second procedures. From 200 consecutive cases requiring bilateral cataract removals 187 were enrolled into this prospective, observational, single-surgeon, single-centre study. To evaluate the pain a 10-point visual analogue scale was used. The pain scores for both eyes of each patient were collected perioperatively (T) as well as 2–4 weeks (mean: 2.43 weeks) later, at the follow-up visit (C). Data were pooled and the four groups were compared by ANOVA All Pairweise Multiple Comparison Procedures. Median C-score was 1 for both eyes, T-score was 1 and 0 for the first and second eye, respectively. There wasn’t any difference between the first and second eyes either in T- (1.50 ± 1.43 vs 1.51 ± 1.36) or in C-scores (0.71 vs 1.10). C-values were lower than T-values for either eye (0.71 vs 1.50 and 1.10 vs 1.51), indicating that patients recalled less pain 2–3 weeks after the surgery than that they indicated on the day of the procedure Consecutive phacoemulsifications do not differ in the perceived pain nevertheless, patients may believe the second eye surgery more painful because they practically compare it with the lower remembered pain for the first eye procedure. In order to avoid any disappointment we suggest warning patients before their second eye operations that they are likely to experience more pain or discomfort.

Background Ingestion of sulphonamide-derived drugs has been reported to possibly have ocular side-effects. Authors aimed to present a rare case of indapamide-induced transient myopia with ciliary body edema and supraciliary effusion. Case presentation A 39 years old caucasian female patient presented at the Department of Neurology with headache and sudden bilateral loss of distant vision. Neurological assessment and cranial CT scans were unremarkable. For her hypertension, twice a day bisoprolol 2.5 mg and once a day indapamide 1.5 mg tablets were prescribed several days before. At her presenting, ophthalmic findings were as follows: visual acuity 0.08-7.25Dsph = 1.0 and 0.06-7.25Dsph = 1.0; IOP 25 mmHg and 24 mmHg, anterior chamber depth (ACD) 2.32 mm and 2.49 mm, lens thickness (L) 4.02 mm and 4.09 mm in the right and the left eye, respectively. By means of ultrasound biomicroscopy (UBM), thickened (720 / 700 micron) and detached ciliary body, its forward movement (ciliary body-cornea angle 108′ / 114′) and forward rotated ciliary processes were seen. Angle opening distance (AOD500) were 300 / 314 microns. By the following days, the myopia gradually diminished, and a week after her first symptoms, her uncorrected visual acuity was 1.0 in both eyes, IOP 13 mmHg and 17 mmHg, ACD 3.68 mm and 3.66 mm, L 3.78 mm and 3.81 mm in the right and the left eye, respectively. Ciliary body edema and detachment disappeared (ciliary body thickness 225 / 230 micron), both of the ciliary body-cornea angle 134′ / 140′ and the AOD500 (650 / 640 microns) increased. At this point, the patient admitted that she had stopped taking indapamide two days before. Conclusions Our case report is the third one in the literature to present indapamide-induced transient myopia, and the first to employ UBM for describing the characteristics of this rare condition. According to the findings, authors suggest that both ciliary muscle contraction and ciliary body edema may play role in the pathomechanism. UBM seems to be a useful tool in the differential diagnosis of acute myopia. Further, authors wish to draw attention to one of the potential adverse effects of this drug which was not listed by its package insert.