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Author(s): Claus Olesen [1, 2]; Martin Picard [3, 4]; Anne-Marie Lund Winther [1, 3]; Claus Gyrup [3]; J. Preben Morth [1, 3]; Claus Oxvig [3]; Jesper Vuust Møller (corresponding author) [...]

A study presents several quantitative analyses of the metzinein metalloproteinase pregnancy-associated plasma protein-A (PAPP-A), which highly initiates the insulin-like growth factor binding protein (IGFBP)-4 and -5. The results show that the described mechanism is extremely important for the control of growth and development of several vertebrate cells and also confirm that PAPP-A acts a very efficient regulator of the insulin-like growth factor (IGF) system.

Introduction: In an oral iron absorption test (OIAT), the rise in plasma iron concentration after oral ingestion of iron is a measure of intestinal iron absorption. We describe results of the OIAT using two different formulations of oral iron drops., Methods: The study included all patients who had an OIAT performed at the Department of Internal Medicine, Farsø, Aalborg University Hospital, Denmark, from 1 January 2013 to 17 June 2014 (n = 24) using ferrous iron drops "Glycifer" and from 18 June to 3 November 2014 (n = 17) using ferric iron drops "Medic". A venous blood sample was drawn before and then 90, 180 and 240 min. after the intake of 9 ml iron drops of the "Glycifer" brand (270 mg ferrous iron) or the intake of 11 ml iron drops of the "Medic" brand (264 mg ferric iron)., Results: The patient characteristics (ferrous versus ferric iron drops) were similar in terms of gender, age, haemoglobin, ferritin and previous gastric bypass surgery. The fasting baseline plasma iron concentration was median 5 μmol/l in both groups (p = 0.4). The maximum plasma iron concen-tration increase from baseline after oral intake of the iron drops was median 2 μmol/l (range: 0-8 μmol/l) in the group given ferric iron drops and 48 μmol/l (range: 14-78 μmol/l) when ferrous iron drops were used (p < 0.001)., Conclusion: OIAT performed with ferrous or ferric iron drops showed very different results with a lack of plasma iron concentration increase after ingestion of ferric iron drops., Funding: none., Trial Registration: not relevant.