Search

Your search keyword '"Gyldensted, Louise"' showing total 34 results
Start Over Author "Gyldensted, Louise"
34 results on '"Gyldensted, Louise"'

1. Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Author

Jensen, Jens-Ulrik Stæhr, Itenov, Theis Skovsgaard, Johansen, Maria Egede, Lundgren, Jens, Tønnesen, Else, Bestle, Morten, Lindhardt, Anne, Christensen, Henrik, Planck Pedersen, Henrik, Poulsen, Lone Musaeus, Cozzi-Lepri, Alessandro, Illkjær, Susanne, Soni, Uday Kant, Møller, Kirsten, Juffermans, Nicole P, Sessler, Daniel I, Mohr, Thomas, Masur, Henry, Torp-Pedersen, Christian, Copas, Andrew, Nielsen, Birgit Riis, Kristensen, Dennis Karsten, Grarup, Jesper, Hansen, Jette, Nielsen, Kim, Valbjørn, Lone, Lauritzen, Sanne, Kold, Tina, Grundahl, Kathrine, Hein, Lars, Rasmussen, Rikke Hein, Wesche, Nikolaj, Blom, Hasse, Jensen, Peer Eske, Galle, Tina, Thaarslund, Bente, Skandov, Camilla, Langholz, Iben, Skram, Ulrik, Berthelsen, Rasmus Ehrenfried, Kjær, Dorthe, Uldbjerg, Merete, Lipsius, Lily, Gyldensted, Louise, Engsig, Magaly, Helsted, Rikke, Andersen, Birgitte, Nygaard, Eigil, Strande, Søren, Bangash, Aimal Khan, Waldau, Tina, Søe-Jensen, Peter, Tousi, Hamid, Tangager, Malene, Hagi-Pedersen, Daniel, Gatz, Rainer Karl-Heinz, Engen, Marte Kaasen, Wamberg, Christian Åge, Westergaard, Bo, Harmon, Matthew, Thormar, Katrin, Stoktoft, Stine, Scherwin, Rebecca, Bærentzen, Finn, Lauritzen, Marlene, Pott, Frank, Bruun, Christina, Meyhoff, Christian, Strange, Ditte Gry, Palmqvist, Dorthe Fris, Hemmingsen, Claus, Gärtner, Rune, Petersen, John Asger, Jung, Kai Dieter, La Porte, Louise, Viuf, Mette, Troglauer, Johannes, Borovnjak, Silva, Strandkjær, Nina, Bretlau, Claus, Hansen, Marianna, Zaulich, Lea Kielsgaard, Overgaard, Christian, Bergenholtz, Katja, Jansen, Tejs, Bæk-Jensen, Mette Astrup, Detlefsen, Monika, Albrechtsen, Tannie Lund, Sode, Birgitte Margareta, Boesen, Hans Christian, Thostrup, Maria, Estrup, Stine, Andersen, Torben Mogens, Kjelsteen, Katrine, Winther Kjær, Cilia Klara, Haunstrup, Elsebeth, Christensen, Ole, Spliid, Lone, Rasmussen, Birgitte, Jejlskov, Henriette, Borchorst, Søren, Abdel-Wahab, Akil Walli Raad, Brysting, Marianne, Victor, Jette, Stensbirk, Anette, Bjerregaard, Karen, Poulsen, Anne, Roed, Annette Brix, Bech, Bianca, Perez-Protto, Silvia, Yilmaz, Oguz, Ahuja, Sanchit, Suleiman, Iman, Iglesias, Rodrigo, Breum, Olena, Pedersen, Henrik Planck, Wesche, Nicolai, Strange, Ditte, Lundgren, Jens D, and Jensen, Jens-Ulrik

Published
2018
Full Text
View/download PDF

3. Mild induced hypothermia and coagulation and platelet function in patients with septic shock: Secondary outcome of a randomized trial

Author

Itenov, Theis S., primary, Kromann, Maria E., additional, Ostrowski, Sisse R., additional, Bestle, Morten H., additional, Mohr, Thomas, additional, Gyldensted, Louise, additional, Lindhardt, Anne, additional, Thormar, Katrin, additional, Sessler, Daniel I., additional, Juffermans, Nicole P., additional, Lundgren, Jens D., additional, and Jensen, Jens‐Ulrik, additional

Published
2023
Full Text
View/download PDF

4. Mild induced hypothermia and coagulation and platelet function in patients with septic shock:Secondary outcome of a randomized trial

Author

Itenov, Theis S., Kromann, Maria E., Ostrowski, Sisse R., Bestle, Morten H., Mohr, Thomas, Gyldensted, Louise, Lindhardt, Anne, Thormar, Katrin, Sessler, Daniel I., Juffermans, Nicole P., Lundgren, Jens D., Jensen, Jens Ulrik, Itenov, Theis S., Kromann, Maria E., Ostrowski, Sisse R., Bestle, Morten H., Mohr, Thomas, Gyldensted, Louise, Lindhardt, Anne, Thormar, Katrin, Sessler, Daniel I., Juffermans, Nicole P., Lundgren, Jens D., and Jensen, Jens Ulrik

Abstract

Coagulation abnormalities and microthrombi contribute to septic shock, but the impact of body temperature regulation on coagulation in patients with sepsis is unknown. We tested the hypothesis that mild induced hypothermia reduces coagulation and platelet aggregation in patients with septic shock. Secondary analysis of randomized controlled trial. Adult patients with septic shock who required mechanical ventilation from eight intensive care units in Denmark were randomly assigned to mild induced hypothermia for 24 h or routine thermal management. Viscoelastography and platelet aggregation were assessed at trial inclusion, after 12 h of thermal management, and 24 h after inclusion. A total of 326 patients were randomized to mild induced hypothermia (n = 163) or routine thermal management (n = 163). Mild induced hypothermia slightly prolonged activated partial thromboplastin time and thrombus initiation time (R time 8.0 min [interquartile range, IQR 6.6–11.1] vs. 7.2 min [IQR 5.8–9.2]; p =.004) and marginally inhibited thrombus propagation (angle 68° [IQR 59–73] vs. 71° [IQR 63–75]; p =.014). The effect was also present after 24 h. Clot strength remained unaffected (MA 71 mm [IQR 66–76] with mild induced hypothermia vs. 72 mm (65–77) with routine thermal management, p =.9). The proportion of patients with hyperfibrinolysis was not affected (0.7% vs. 3.3%; p =.19), but the proportion of patients with no fibrinolysis was high in the mild hypothermia group (8.8% vs. 40.4%; p <.001). The mild induced hypothermia group had lower platelet aggregation: ASPI 85U (IQR 50–113) versus 109U (IQR 74–148, p <.001), ADP 61U (IQR 40–83) versus 79 U (IQR 54–101, p <.001), TRAP 108 (IQR 83–154) versus 119 (IQR 94–146, p =.042) and COL 50U (IQR 34–66) versus 67U (IQR 46–92, p <.001). In patients with septic shock, mild induced hypothermia slightly impaired clot initiation, but did not change clot strength. Platelet aggregation was slightly impaired. The effect of mild ind

Published
2023

5. Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial

Author

Kjaer, Maj-Brit N., Meyhoff, Tine S., Madsen, Martin B., Hjortrup, Peter B., Moller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jorn, Lange, Theis, Cronhjort, Maria, Laake, Jon H., Jakob, Stephan M., Nalos, Marek, Pettila, Ville, van der Horst, Iwan C. C., Ostermann, Marlies, Mouncey, Paul, Cecconi, Maurizio, Ferrer, Ricard, Malbrain, Manu L. N. G., Ahlstedt, Christian, Hoffmann, Soren, Bestle, Morten H., Gyldensted, Louise, Nebrich, Lars, Russell, Lene, Vang, Marianne, Solling, Christoffer, Brochner, Anne C., Rasmussen, Bodil S., Perner, Anders, Kjaer, Maj-Brit N., Meyhoff, Tine S., Madsen, Martin B., Hjortrup, Peter B., Moller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jorn, Lange, Theis, Cronhjort, Maria, Laake, Jon H., Jakob, Stephan M., Nalos, Marek, Pettila, Ville, van der Horst, Iwan C. C., Ostermann, Marlies, Mouncey, Paul, Cecconi, Maurizio, Ferrer, Ricard, Malbrain, Manu L. N. G., Ahlstedt, Christian, Hoffmann, Soren, Bestle, Morten H., Gyldensted, Louise, Nebrich, Lars, Russell, Lene, Vang, Marianne, Solling, Christoffer, Brochner, Anne C., Rasmussen, Bodil S., and Perner, Anders

Published
2020

6. Long‐term patient‐important outcomes after septic shock: A protocol for 1‐year follow‐up of the CLASSIC trial

Author

Kjær, Maj‐Brit N., primary, Meyhoff, Tine S., additional, Madsen, Martin B., additional, Hjortrup, Peter B., additional, Møller, Morten Hylander, additional, Egerod, Ingrid, additional, Wetterslev, Jørn, additional, Lange, Theis, additional, Cronhjort, Maria, additional, Laake, Jon H., additional, Jakob, Stephan M., additional, Nalos, Marek, additional, Pettilä, Ville, additional, van der Horst, Iwan C. C., additional, Ostermann, Marlies, additional, Mouncey, Paul, additional, Cecconi, Maurizio, additional, Ferrer, Ricard, additional, Malbrain, Manu L. N. G., additional, Ahlstedt, Christian, additional, Hoffmann, Søren, additional, Bestle, Morten H., additional, Gyldensted, Louise, additional, Nebrich, Lars, additional, Russell, Lene, additional, Vang, Marianne, additional, Sølling, Christoffer, additional, Brøchner, Anne C., additional, Rasmussen, Bodil S., additional, and Perner, Anders, additional

Published
2019
Full Text
View/download PDF

9. Induced hypothermia in patients with septic shock and respiratory failure (CASS):a randomised, controlled, open-label trial

Author

Itenov, Theis Skovsgaard, Johansen, Maria Egede, Bestle, Morten, Thormar, Katrin, Hein, Lars, Gyldensted, Louise, Lindhardt, Anne, Christensen, Henrik, Estrup, Stine, Pedersen, Henrik Planck, Harmon, Matthew, Soni, Uday Kant, Perez-Protto, Silvia, Wesche, Nicolai, Skram, Ulrik, Petersen, John Asger, Mohr, Thomas, Waldau, Tina, Poulsen, Lone Musaeus, Strange, Ditte, Juffermans, Nicole P, Sessler, Daniel I, Tønnesen, Else, Møller, Kirsten, Kristensen, Dennis Karsten, Cozzi-Lepri, Alessandro, Lundgren, Jens D, Jensen, Jens-Ulrik, Hägi-Pedersen, Daniel, Poulsen, Anne, Nielsen, Kim G., Itenov, Theis Skovsgaard, Johansen, Maria Egede, Bestle, Morten, Thormar, Katrin, Hein, Lars, Gyldensted, Louise, Lindhardt, Anne, Christensen, Henrik, Estrup, Stine, Pedersen, Henrik Planck, Harmon, Matthew, Soni, Uday Kant, Perez-Protto, Silvia, Wesche, Nicolai, Skram, Ulrik, Petersen, John Asger, Mohr, Thomas, Waldau, Tina, Poulsen, Lone Musaeus, Strange, Ditte, Juffermans, Nicole P, Sessler, Daniel I, Tønnesen, Else, Møller, Kirsten, Kristensen, Dennis Karsten, Cozzi-Lepri, Alessandro, Lundgren, Jens D, Jensen, Jens-Ulrik, Hägi-Pedersen, Daniel, Poulsen, Anne, and Nielsen, Kim G.

Abstract

BACKGROUND: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock.METHODS: In this randomised, controlled, open-label trial, we recruited patients from ten intensive care units (ICUs) in three countries in Europe and North America. Inclusion criteria for patients with severe sepsis or septic shock were a mean arterial pressure of less than 70 mm Hg, mechanical ventilation in an ICU, age at least 50 years, predicted length of stay in the ICU at least 24 h, and recruitment into the study within 6 h of fulfilling inclusion criteria. Exclusion criteria were uncontrolled bleeding, clinically important bleeding disorder, recent open surgery, pregnancy or breastfeeding, or involuntary psychiatric admission. We randomly allocated patients 1:1 (with variable block sizes ranging from four to eight; stratified by predictors of mortality, age, Acute Physiology and Chronic Health Evaluation II score, and study site) to routine thermal management or 24 h of induced hypothermia (target 32-34°C) followed by 48 h of normothermia (36-38°C). The primary endpoint was 30 day all-cause mortality in the modified intention-to-treat population (all randomly allocated patients except those for whom consent was withdrawn or who were discovered to meet an exclusion criterion after randomisation but before receiving the trial intervention). Patients and health-care professionals giving the intervention were not masked to treatment allocation, but assessors of the primary outcome were. This trial is registered with ClinicalTrials.gov, number NCT01455116.FINDINGS: Between Nov 1, 2011, and Nov 4, 2016, we screened 5695 patients. After recruitment of 436 of the planned 560 participants, the trial was terminated for futil

Published
2018

10. Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Author

Itenov, Theis Skovsgaard, primary, Johansen, Maria Egede, additional, Bestle, Morten, additional, Thormar, Katrin, additional, Hein, Lars, additional, Gyldensted, Louise, additional, Lindhardt, Anne, additional, Christensen, Henrik, additional, Estrup, Stine, additional, Pedersen, Henrik Planck, additional, Harmon, Matthew, additional, Soni, Uday Kant, additional, Perez-Protto, Silvia, additional, Wesche, Nicolai, additional, Skram, Ulrik, additional, Petersen, John Asger, additional, Mohr, Thomas, additional, Waldau, Tina, additional, Poulsen, Lone Musaeus, additional, Strange, Ditte, additional, Juffermans, Nicole P, additional, Sessler, Daniel I, additional, Tønnesen, Else, additional, Møller, Kirsten, additional, Kristensen, Dennis Karsten, additional, Cozzi-Lepri, Alessandro, additional, Lundgren, Jens D, additional, Jensen, Jens-Ulrik, additional, Jensen, Jens-Ulrik Stæhr, additional, Itenov, Theis Skovsgaard, additional, Lundgren, Jens, additional, Planck Pedersen, Henrik, additional, Illkjær, Susanne, additional, Masur, Henry, additional, Torp-Pedersen, Christian, additional, Copas, Andrew, additional, Nielsen, Birgit Riis, additional, Grarup, Jesper, additional, Hansen, Jette, additional, Nielsen, Kim, additional, Valbjørn, Lone, additional, Lauritzen, Sanne, additional, Kold, Tina, additional, Grundahl, Kathrine, additional, Rasmussen, Rikke Hein, additional, Wesche, Nikolaj, additional, Blom, Hasse, additional, Jensen, Peer Eske, additional, Galle, Tina, additional, Thaarslund, Bente, additional, Skandov, Camilla, additional, Langholz, Iben, additional, Berthelsen, Rasmus Ehrenfried, additional, Kjær, Dorthe, additional, Uldbjerg, Merete, additional, Lipsius, Lily, additional, Engsig, Magaly, additional, Helsted, Rikke, additional, Andersen, Birgitte, additional, Nygaard, Eigil, additional, Strande, Søren, additional, Bangash, Aimal Khan, additional, Søe-Jensen, Peter, additional, Tousi, Hamid, additional, Tangager, Malene, additional, Hagi-Pedersen, Daniel, additional, Gatz, Rainer Karl-Heinz, additional, Engen, Marte Kaasen, additional, Wamberg, Christian Åge, additional, Westergaard, Bo, additional, Stoktoft, Stine, additional, Scherwin, Rebecca, additional, Bærentzen, Finn, additional, Lauritzen, Marlene, additional, Pott, Frank, additional, Bruun, Christina, additional, Meyhoff, Christian, additional, Strange, Ditte Gry, additional, Palmqvist, Dorthe Fris, additional, Hemmingsen, Claus, additional, Gärtner, Rune, additional, Jung, Kai Dieter, additional, La Porte, Louise, additional, Viuf, Mette, additional, Troglauer, Johannes, additional, Borovnjak, Silva, additional, Strandkjær, Nina, additional, Bretlau, Claus, additional, Hansen, Marianna, additional, Zaulich, Lea Kielsgaard, additional, Overgaard, Christian, additional, Bergenholtz, Katja, additional, Jansen, Tejs, additional, Bæk-Jensen, Mette Astrup, additional, Detlefsen, Monika, additional, Albrechtsen, Tannie Lund, additional, Sode, Birgitte Margareta, additional, Boesen, Hans Christian, additional, Thostrup, Maria, additional, Andersen, Torben Mogens, additional, Kjelsteen, Katrine, additional, Winther Kjær, Cilia Klara, additional, Haunstrup, Elsebeth, additional, Christensen, Ole, additional, Spliid, Lone, additional, Rasmussen, Birgitte, additional, Jejlskov, Henriette, additional, Borchorst, Søren, additional, Abdel-Wahab, Akil Walli Raad, additional, Brysting, Marianne, additional, Victor, Jette, additional, Stensbirk, Anette, additional, Bjerregaard, Karen, additional, Poulsen, Anne, additional, Roed, Annette Brix, additional, Bech, Bianca, additional, Yilmaz, Oguz, additional, Ahuja, Sanchit, additional, Suleiman, Iman, additional, Iglesias, Rodrigo, additional, and Breum, Olena, additional

Published
2018
Full Text
View/download PDF

11. Induced Hypothermia in Patients with Septic Shock and Ventilator-demanding Respiratory Failure

Author

Itenov, Theis Skovsgaard, primary, Johansen, Maria Egede, additional, Bestle, Morten, additional, Thormar, Katrin, additional, Hein, Lars, additional, Gyldensted, Louise, additional, Lindhardt, Anne, additional, Christensen, Henrik, additional, Damby, Stine Estrup, additional, Pedersen, Henrik Planck, additional, Harmon, Matthew, additional, Soni, Uday Kant, additional, Perez-Protto, Silvia, additional, Wesche, Nikolaj, additional, Berthelsen, Rasmus Ehrenfried, additional, Skram, Ulrik, additional, Petersen, Asger, additional, Mohr, Thomas, additional, Waldau, Tina, additional, Poulsen, Lone Museus, additional, Strange, Ditte, additional, Christensen, Ole, additional, Juffermans, Nicole P, additional, Sessler, Daniel, additional, Tønnesen, Else, additional, Kristensen, Dennis, additional, Cozzi-Lepri, Alessandro, additional, Lundgren, Jens, additional, and Jensen, Jens Ulrik Stæhr, additional

Published
2017
Full Text
View/download PDF

12. Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

Author

Eskildsen, Simon Fristed, Gyldensted, Louise, Nagenthiraja, Kartheeban, Hansen, Mikkel Bo, Dalby, Rikke Beese, Frandsen, Jesper, Rodell, Anders, Gyldensted, Carsten, Jespersen, Sune Nørhøj, Mouridsen, Kim, Brændgaard, Hans, and Østergaard, Leif

Abstract

Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.

Published
2015

14. Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease

Author

Eskildsen, Simon Fristed, Gyldensted, Louise, Nagenthiraja, Kartheeban, Frandsen, Jesper, Rodell, Anders, Gyldensted, Carsten, Jespersen, Sune Nørhøj, Mouridsen, Kim, Brændgaard, Hans, and Østergaard, Leif

Subjects
OEF, Alzheimer, capillary dysfunction, perfusion, MRI
Abstract

Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed [1]. The model predicts that increased capillary dysfunction leads to increased oxygen extraction in order to support the metabolic requirements of the brain tissues. In this study we investigated the brain oxygen extraction capacity (OEFmax) in AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI).Increased OEFmax was detected in the temporal, parietal and frontal lobes of AD patients compared to controls. These findings are consistent with the capillary dysfunction hypothesis of AD [1]. The widespread cortical atrophy and smaller hippocampal volumes in the AD patients suggest pathologies of late Braak stages. Further studies should address the causal relation between elevated OEFmax and atrophy.

Published
2013

15. [Cerebral manifestations of influenza A (H1N1)v]

Author

Christensen, Pia Sønderby, Pedersen, Birgitte Bang, Gulisano, Helga, Gyldensted, Louise, and Nielsen, Henrik Ib

Subjects
Adult, Male, Decompressive Craniectomy, Influenza A Virus, H1N1 Subtype, Adolescent, Influenza, Human, Humans, Brain Edema, Encephalitis, Viral, Intracranial Hypertension, Magnetic Resonance Imaging
Abstract

We describe two patients with cerebral manifestations of influenza A (H1N1)v. A 13-year-old boy developed severe cerebral oedema and increased intracranial pressure despite medical treatment and external drainage of cerebrospinal fluid. He was treated with bifrontal decompressive craniectomy with good result. A 25-year-old man with a previous kidney transplant developed encephalopathy and convulsions. Magnetic resonance imaging showed encephalitis. The patient fully recovered. The cases demonstrate that influenza A (H1N1)v can cause seriously and potentially life-threatening neurological complications.

Published
2010

16. P4‐062: Cortical capillary dysfunction in patients suspected of Alzheimer's disease

Author

Eskildsen, Simon Fristed, primary, Gyldensted, Louise, additional, Nagenthiraja, Kartheeban, additional, Hansen, Mikkel Bo, additional, Dalby, Rikke Beese, additional, Frandsen, Jesper, additional, Rodell, Anders, additional, Gyldensted, Carsten, additional, Jespersen, Sune Nørhøj, additional, Mouridsen, Kim, additional, Brændgaard, Hans, additional, and Østergaard, Leif, additional

Published
2015
Full Text
View/download PDF

17. IC-04-01: Cortical capillary dysfunction in patients suspected of Alzheimer's disease

Author

Eskildsen, Simon Fristed, primary, Gyldensted, Louise, additional, Nagenthiraja, Kartheeban, additional, Hansen, Mikkel Bo, additional, Dalby, Rikke Beese, additional, Frandsen, Jesper, additional, Rodell, Anders, additional, Gyldensted, Carsten, additional, Jespersen, Sune Nørhøj, additional, Mouridsen, Kim, additional, Braendgaard, Hans, additional, and Østergaard, Leif, additional

Published
2015
Full Text
View/download PDF

23. P1‐239: CAPILLARY TRANSIT TIME HETEROGENEITY IN THE CEREBRUM CORRELATE WITH COGNITIVE DECLINE IN AD

Author

Eskildsen, Simon Fristed, primary, Gyldensted, Louise, additional, Nagenthiraja, Kartheeban, additional, Hansen, Mikkel, additional, Dalby, Rikke, additional, Frandsen, Jesper, additional, Rodell, Anders, additional, Gyldensted, Carsten, additional, Jespersen, Sune Nørhøj, additional, Mouridsen, Kim, additional, Brændgaard, Hans, additional, and Østergaard, Leif, additional

Published
2014
Full Text
View/download PDF

24. IC‐P‐154: CAPILLARY TRANSIT TIME HETEROGENEITY IN THE CEREBRUM CORRELATE WITH COGNITIVE DECLINE IN AD

Author

Eskildsen, Simon Fristed, primary, Gyldensted, Louise, additional, Nagenthiraja, Kartheeban, additional, Hansen, Mikkel, additional, Dalby, Rikke, additional, Frandsen, Jesper, additional, Rodell, Anders, additional, Gyldensted, Carsten, additional, Jespersen, Sune Nørhøj, additional, Mouridsen, Kim, additional, Brændgaard, Hans, additional, and Østergaard, Leif, additional

Published
2014
Full Text
View/download PDF

27. P1-310: Capillary dysfunction in Alzheimer's disease

Author

Østergaard, Leif, primary, Nagenthiraja, Kartheeban, additional, Gyldensted, Louise, additional, Rodell, Anders, additional, Gyldensted, Carsten, additional, Jespersen, Sune Nørhøj, additional, Mouridsen, Kim, additional, Braendgaard, Hans, additional, and West, Mark, additional

Published
2013
Full Text
View/download PDF

32. Long-term patient-important outcomes after septic shock: a protocol for 1-year follow-up of the CLASSIC-trial

Author

Kjaer, Maj-Brit Nørregaard, Meyhoff, Tine Sylvest, Madsen, Martin Bruun, Hjortrup, Peter Buhl, Møller, Morten Hylander, Egerod, Ingrid, Wetterslev, Jørn, Lange, Theis, Cronhjort, Maria, Laake, Jon Henrik, Jakob, Stephan M., Nalos, Marek, Pettilä, Ville, Van Der Horst, Iwan C C, Ostermann, Marlies, Mouncey, Paul, Cecconi, Maurizio, Ferrer, Ricard, L N G Malbrain, Manu, Ahlstedt, Christian, Hoffmann, Søren, Bestle, Morten H, Gyldensted, Louise, Nebrich, Lars, Russell, Lene, Vang, Marianne, Sølling, Christoffer, Brøchner, Anne Craveiro, Rasmussen, Bodil Steen, and Perner, Anders

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND In patients with septic shock mortality is high, and survivors experience long-term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial assesses the benefits and harms of a restrictive versus (vs) standard-care intravenous (IV) fluid therapy. The hypothesis is that IV fluid restriction improves patient-important long-term outcomes. AIM To assess the predefined patient-important long-term outcomes in patients randomised into the CLASSIC trial. METHODS In this pre-planned follow-up study of the CLASSIC trial, we will assess all-cause mortality, Health-Related Quality of Life (HRQoL) and cognitive function one year after randomisation in the two intervention groups. The 1-year mortality will be collected from electronic patient records or central national registries in most participating countries. We will contact survivors and assess EuroQol 5-Dimension, -5-Level (EQ-5D-5L) and EuroQol-Visual Analogue Scale and Montreal Cognitive Assessment 5-minute protocol score. We will analyse mortality by logistic regression and use general linear models to assess HRQoL and cognitive function. DISCUSSION With this pre-planned follow-up study of the CLASSIC trial, we will provide patient-important data on long-term survival, HRQoL and cognitive function of restrictive vs standard-care IV fluid therapy in patients with septic shock.

33. Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial.

Author

Kjaer MN, Meyhoff TS, Madsen MB, Hjortrup PB, Møller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst ICC, Ostermann M, Mouncey P, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Gyldensted L, Nebrich L, Russell L, Vang M, Sølling C, Brøchner AC, Rasmussen BS, and Perner A

Subjects
Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survivors statistics & numerical data, Time, Cognitive Dysfunction etiology, Quality of Life, Research Design, Shock, Septic complications, Shock, Septic mortality
Abstract

Background: In patients with septic shock, mortality is high, and survivors experience long-term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial assesses the benefits and harms of a restrictive vs standard-care intravenous (IV) fluid therapy. The hypothesis is that IV fluid restriction improves patient-important long-term outcomes., Aim: To assess the predefined patient-important long-term outcomes in patients randomised into the CLASSIC trial., Methods: In this pre-planned follow-up study of the CLASSIC trial, we will assess all-cause mortality, health-related quality of life (HRQoL) and cognitive function 1 year after randomisation in the two intervention groups. The 1-year mortality will be collected from electronic patient records or central national registries in most participating countries. We will contact survivors and assess EuroQol 5-Dimension, -5-Level (EQ-5D-5L) and EuroQol-Visual Analogue Scale and Montreal Cognitive Assessment 5-minute protocol score. We will analyse mortality by logistic regression and use general linear models to assess HRQoL and cognitive function., Discussion: With this pre-planned follow-up study of the CLASSIC trial, we will provide patient-important data on long-term survival, HRQoL and cognitive function of restrictive vs standard-care IV fluid therapy in patients with septic shock., (© 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)

Published
2020
Full Text
View/download PDF

34. [Cerebral manifestations of influenza A (H1N1)v].

Author

Christensen PS, Pedersen BB, Gulisano H, Gyldensted L, and Nielsen HI

Subjects
Adolescent, Adult, Brain Edema etiology, Decompressive Craniectomy, Encephalitis, Viral complications, Encephalitis, Viral etiology, Humans, Influenza, Human complications, Intracranial Hypertension etiology, Magnetic Resonance Imaging, Male, Brain Edema virology, Encephalitis, Viral virology, Influenza A Virus, H1N1 Subtype, Influenza, Human virology, Intracranial Hypertension virology
Abstract

We describe two patients with cerebral manifestations of influenza A (H1N1)v. A 13-year-old boy developed severe cerebral oedema and increased intracranial pressure despite medical treatment and external drainage of cerebrospinal fluid. He was treated with bifrontal decompressive craniectomy with good result. A 25-year-old man with a previous kidney transplant developed encephalopathy and convulsions. Magnetic resonance imaging showed encephalitis. The patient fully recovered. The cases demonstrate that influenza A (H1N1)v can cause seriously and potentially life-threatening neurological complications.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results