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This paper investigates the relationship between morphological productivity and neological intuition, defined as the ability to identify novel words as such. It can be hypothesised that the more productive a word-formation process is, the less salient the neologisms it forms will be. We test this hypothesis experimentally on neologisms formed with prefixes and suffixes of variable productivity. Three experiments are conducted, involving lexical identification and reading tasks with eye tracking, to provide a comprehensive description of neological intuition. The negative correlation between productivity and neological salience is supported by experimental results, but only in the case of suffixed neologisms, as opposed to prefixed ones. The effect of affix type on neological intuition can be explained by differences in the grammatical nature of prefixes and suffixes. Broadly speaking, investigating the linguistic factors of neological intuition provides an original approach to both linguistic and psycholinguistic issues related to word structure and lexical processing.

Abstract Sexual dimorphism arises because of divergent fitness optima between the sexes. Phenotypic divergence between sexes can range from mild to extreme. Fireflies, bioluminescent beetles, present various degrees of sexual dimorphism, with species showing very mild sexual dimorphism to species presenting female-specific neoteny, posing a unique framework to investigate the evolution of sexually dimorphic traits across species. In this work, we present novel assembled genomes of two firefly species, Lamprohiza splendidula and Luciola italica, species with different degrees of sexual dimorphism. We uncover high synteny conservation of the X-chromosome across ~ 180 Mya and find full X-chromosome dosage compensation in our two fireflies, hinting at common mechanism upregulating the single male X-chromosome. Different degrees of sex-biased expressed genes were found across two body parts showing different proportions of expression conservation between species. Interestingly, we do not find X-chromosome enrichment of sex-biased genes, but retrieve autosomal enrichment of sex-biased genes. We further uncover higher nucleotide diversity in the intronic regions of sex-biased genes, hinting at a maintenance of heterozygosity through sexual selection. We identify different levels of sex-biased gene expression divergence including a set of genes showing conserved sex-biased gene expression between species. Divergent and conserved sex-biased genes are good candidates to test their role in the maintenance of sexually dimorphic traits.

Despite the increased use of different types of gender-fair forms in French, studies investigating how they are interpreted when presented in a sentence remain few. To fill this gap, we conducted a pre-registered study using a timed sentence evaluation task to examine the possibility of speakers’ establishing an anaphoric relationship between a gendered anaphoric expression (femmes ‘women’ or hommes ‘men’) and non-stereotyped role nouns as antecedents. The antecedents were presented in their masculine form or in one out of three different gender-fair forms (complete double forms: les voisines et voisins ‘the neighbours.FEM and neighbours.MASC’, contracted double forms: les voisin·es ‘the neighbours.MASC·FEM’, or gender-neutral forms: le voisinage ‘the neighbourhood’). In line with previous findings, the masculine form led to a male bias in the participants’ mental representations of gender. All three examined gender-fair forms resolved this bias, but comparisons of the different forms to each other revealed differences between them. The results show that complete double forms lead to equally balanced mental representations of gender while contracted double forms slightly favour representation of women. Finally, gender-neutral forms result in a small male bias, although significantly smaller than the one produced by the masculine form. The results are discussed in relation to the mental models theory and provide new and important insights on how gender-fair forms in French are interpreted.

Abstract Urbanization gradients are increasingly used in ecological studies to discover responses of species communities to different intensities of human-induced habitat transformation. Here, we investigated patterns of bat communities against the background of different urbanization levels using a priori defined urbanization categories based on distance classes (5 km intervals) along a linear transect from the urban core of the city of Berlin westwards into the rural outskirts of the state of Brandenburg. Using linear-mixed effects models, we found that “distance class”, as a proxy for urbanization level, is a meaningful and suitable predictor of bat species richness and diversity. We observed an unexpectedly sudden increase in bat species richness and diversity and changes in species-specific activity levels relatively close to the urban center at the transition between urban and peri-urban areas. This change suggests a relevant influence of the peri-urban areas as a “buffer zone” for specific bat species not able to adapt to the heavily modified inner core of the metropolitan area. Although we could demonstrate that anthropogenic noise and artificial light have the potential to predict the variability of bat species activity along the urban–rural gradient, the actual influence on observed shifts in the bat community needs further research.

Human granulocytotropic anaplasmosis (HGA) is a zoonotic tick-borne bacterial infection caused by Anaplasma phagocytophilum. While most cases are reported from North America, HGA has been recognized as an emerging disease in several regions of the world in recent decades. Most available data comes from case reports, case series and retrospective studies, while prospective studies and clinical trials are largely lacking. To obtain a clearer picture of the currently known epidemiologic distribution, clinical and paraclinical presentation, diagnostic aspects, complications, therapeutic aspects, and outcomes of HGA, we systematically reviewed the literature and analyzed and summarized the data. Cases of HGA are reported from all continents except from Antarctica. HGA primarily presents as an unspecific febrile illness (88.5% of the cases) often accompanied by thrombocytopenia (71.8% of the cases), abnormal liver injury tests (66.7% of the cases), and leukopenia (49.8% of the cases). Although we found complications reported in a total of 40.5% of the reviewed cases and severe and even life-threatening complications are not infrequent (e.g. acute renal failure 9.8%, multi organ failure 7.5%, ARDS 6.3%, a.o.), sequelae are rare (2.1% of the cases) and lethality is low (3.0% of the cases). Treatment with doxycycline shows a rapid response, with the fever subsiding in the majority of patients within one day of starting treatment. Unlike in human monocytotropic ehrlichiosis (HME), reports of opportunistic infections complicating HGA are rare. HGA during pregnancy does not appear to be associated with unfavorable outcomes. In addition, our analysis provides some evidence that HGA may differ in clinical aspects and laboratory characteristics in different regions of the world. Overall, the data analyzed indicates a non-negligible bias in reporting/publication, so a certain degree of caution is required when generalizing the data.

Abstract: Introduction: Social and contextual factors play an important role for elite athletes’ mental health. In the present study, we examined how young elite athletes’ coach-athlete relationship appraisals are associated with and longitudinally predict general and athlete-specific burnout symptoms and whether mental toughness moderates the association between the coach-athlete relationship and burnout symptoms. Methods: In this prospective study, data were collected twice within a 6 to 10-month interval. The sample consisted of 295 athletes attending Swiss Olympic Partner Schools (186 boys, 109 girls), with a mean age of 16.73±1.38 years. The following instruments were applied: Coach-Athlete Relationship Questionnaire (CART-Q), Athlete Burnout Questionnaire (ABQ), Shirom-Melamed Burnout Measure (SMBM), and Mental Toughness Questionnaire (MTQ). Cross-lagged panel analyses were performed to examine reciprocal relationships across time. Interaction effects were tested via hierarchical regression analyses. Results: Cross-sectionally, athletes who perceived their coach-athlete relationship as negative reported more general and athlete-specific burnout symptoms. Burnout symptoms were relatively stable across time, which made it difficult to explain further variance via coach-athlete relationship appraisals in the prospective analyses. While higher mental toughness scores were associated with fewer burnout symptoms in the cross-sectional analyses, higher mental toughness did not moderate the association between the coach-athlete relationship and burnout symptoms. Conclusion: The coach-athlete relationship plays an important role in athletes’ mental health. Therefore, coaches need the ability to develop effective relationships with their athletes, including thoughtful and respectful communication about issues specific to sport and life generally.

Abstract Reciprocal Copy Number Variants (CNVs) at the 16p11.2 locus confer high risk for autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs). Morphometric MRI studies have revealed large and pervasive volumetric alterations in carriers of a 16p11.2 deletion. However, the specific neuroanatomical mechanisms underlying such alterations, as well as their developmental trajectory, are still poorly understood. Here we explored differences in microstructural brain connectivity between 24 children carrying a 16p11.2 deletion and 66 typically developing (TD) children between 2 and 8 years of age. We found a large pervasive increase of intra-axonal volume widespread over a high number of white matter tracts. Such microstructural alterations in 16p11.2 deletion children were already present at an early age, and led to significant changes in the global efficiency and integration of brain networks mainly associated to language, motricity and socio-emotional behavior, although the widespread pattern made it unlikely to represent direct functional correlates. Our results shed light on the neuroanatomical basis of the previously reported increase of white matter volume, and align well with analogous evidence of altered axonal diameter and synaptic function in 16p11.2 mice models. We provide evidence of a prevalent mechanistic deviation from typical maturation of brain structural connectivity associated with a specific biological risk to develop ASD. Future work is warranted to determine how this deviation contributes to the emergence of symptoms observed in young children diagnosed with ASD and other NDDs.

Real-Time Location Systems (RTLSs) are promising precision livestock farming tools and have been employed in behavioural studies across various farm animal species. However, their application in research with fattening pigs is so far unexplored. The implementation of these systems has great potential to gain insight into pigs’ spatial behaviour such as the use of functional areas and pigs’ proximity to each other as indicators for social relationships. The aim of this study was therefore to validate the accuracy, precision, and data quality of the commercial Noldus Information Technology BV TrackLab system. We conducted different measurement sets: first, we performed static measurements in 12 pens at four different locations in each pen at three heights each using a single ultra-wideband tag (UWB). We recorded unfiltered x- and y-coordinates at 1 Hz. We repeated these measurements with six tags aligned in a 2 × 3 grid with varied spacing to test interference between the tags. We also tested dynamic performance by moving the tags along the centre line of the pens. Finally, we measured the data quality with 55 growing pigs in six pens, including the identification of location 'jumps' from the inside to the outside of the pen. Each pen housed ten animals fitted with a UWB tag attached to their farm ear tag. We collected data for 10 days and analysed seven 24-h periods of raw and filtered data. The mean accuracy of the RTLS measurements was 0.53 m (precision: 0.14 m) for single and 0.46 m (precision: 0.07 m) for grouped tags. Accuracy improved with increasing measurement height for single tags but less clearly for grouped tags (P [height single] = 0.01; P [height grouped] = 0.22). When tags were fitted to animals, 63.3% of the filtered data was lost and 21.8% of the filtered location estimates were outside the pens. Altogether, the TrackLab system was capable of fairly accurate and precise assignment of the functional areas where individual animals were located, but was insufficient for the analysis of social relationships. Furthermore, the frequent occurrence of gaps in signal transmission and the overall high data loss rates presented significant limitations. Additionally, the challenging hardware requirements for attaching sensors to the animals underline the need for further technological advances in RTLS for the application with growing-finishing pigs.

A common goal for gender-fair language policies is to promote terms that elicit balanced activation of gender categories. Expanding previous research on the activation of feminine versus masculine categories through person nouns, we used a word-picture response priming design with gendered human faces as target stimuli, to explore whether a simultaneous activation of more than one gender category can be captured empirically. Focusing on Norwegian (Bokmål), we tested whether reading stereotypical (i.e. role nouns, e.g. “care givers”) and categorical gendered person nouns (i.e. name pairs, e.g. “Elin and Sandra”) facilitates the categorisation of face pairs that match the gender of the designated people. In Experiment 1 (N = 32), gender-specific (feminine or masculine) word primes were tested, before gender-balanced word primes (non-stereotyped role nouns; pairs of a female and a male name) were added in Experiment 2 (N = 39). In both experiments, the visual targets were pairs of faces (two female faces, two male faces, or one male and one female face). Consistent with previous results for English, we found gender-specific priming effects, supporting the notion that gender categories activated by linguistic stimuli may also exert influence outside of language processing. Most importantly, mixed-gender faces were successfully primed by non-stereotypical role nouns providing initial support for the idea of a balanced activation of gender categories.

Behavioural complexity is likely to reflect how animals cope with their environment. A large behavioural repertoire and the ability to flexibly apply these behaviours provide an individual with a greater likelihood of adapting to its (captive) environment. Here, we developed a procedure to aggregate different behavioural measures into a condensed measure of behavioural complexity based on 14 features, which were previously proposed (e.g. number of behaviours, Shannon diversity index) as well as some new features of behavioural complexity (e.g. variances of within and between transition durations). To test the measure, artificial behavioural sequences with potentially varying complexity were created using an individual-based modelling approach. With a Principal Component Analysis, the features extracted from these sequences could be reduced to two components (‘general complexity’ and ‘state variability’) explaining 59.64 and 27.68% of the total variance, respectively. The effect of the aspects of the artificial behavioural sequences on ‘general complexity’ and ‘transitions variability’ were analysed using linear mixed-effects models. The number of behavioural categories and the proportion of short behavioural states had the largest effect on the components. Both components were increasing with a greater number of behavioural categories, whereas the proportion of short behavioural states the opposite effect on the components. We also tested the approach on real data-sets. The principle components were not identical to the ones from the simulation. Yet, we found consistencies and similarities in the loadings. The approach for an aggregated measure of behavioural complexity developed here could form the basis of an individual-based animal welfare indicator for intensively kept animals.

Many connectives, such as "therefore" and "however," are used very frequently in the written modality. Their acquisition thus represents an important milestone in developing written language competences. In this article, we assess the development of competence with such connectives by native French speakers in a sentence-level insertion task (N = 307, aged 12 to 64) and a text-level insertion task (N = 172, aged 13 to 71). Our results indicate that, despite a general progression in the level of competence with age, the academic level of participants is a strong predictor of competence within each age group, even during adulthood. In addition, from the age of 12, competence is related to the frequency of connectives in naturalistic data, with frequent connectives systematically mastered better than less frequent ones. Finally, in all age groups, the use and understanding of connectives is more challenging when sentences to complete are embedded within a richer context than when presented alone.

Abstract: Introduction: Finding ways to efficiently monitor the balance between recovery and stress is one of the most frequent requests from coaches and athletes and probably one of the best ways to prevent maladaptive psychological and physiological states. Therefore, the purpose of the present study was to monitor recovery-stress states of adolescent elite athletes across an entire school year using the 32-item Acute Recovery and Stress Scale (ARSS), and to examine the predictive value of recovery and stress states for depressive symptoms, burnout symptoms, and insomnia symptoms. Methods: Data are based on a 10-month longitudinal observational study. The sample consisted of 135 adolescent elite athletes (Mage=16.8 years) recruited from Swiss Olympic Partner Schools. The participants completed the ARSS 19 times (every second week), the Patient Health Questionnaire (PHQ-9), the Shirom-Melamed Burnout Measure (SMBM) and the Insomnia Severity Index (ISI) at baseline and follow-up. Results: Participants reported higher recovery than stress states across the entire school year. However, lower recovery and higher stress states significantly predicted mental health problems as indexed by depressive, burnout and insomnia symptoms. The predictive power of recovery and stress states was similar for depressive and burnout symptoms. For insomnia symptoms, only recovery state was a significant predictor. Conclusion: Our study highlights that a short psychometric instrument allows longitudinal monitoring of recovery-stress states. Coaches are encouraged to implement such an instrument to identify periods that are characterized by high stress and/or low recovery. Continuous monitoring may allow the timely implementation of prevention and intervention strategies in the training process.

The growing literature on gender inequality in academia attests to the challenge that awaits female researchers during their academic careers. However, research has not yet conclusively resolved whether these biases persist during the peer review process of research grant funding and whether they impact respective funding decisions. Whereas many have argued for the existence of gender inequality in grant peer reviews and outcomes, others have demonstrated that gender equality is upheld during these processes. In the present paper, we illustrate how these opinions have come to such opposing conclusions and consider methodological and contextual factors that render these findings inconclusive. More specifically, we argue that a more comprehensive approach is needed to further the debate, encompassing individual and systemic biases as well as more global social barriers. We also argue that examining gender biases during the peer review process of research grant funding poses critical methodological challenges that deserve special attention. We conclude by providing directions for possible future research and more general considerations that may improve grant funding opportunities and career paths for female researchers.

In this work, we investigated the technical feasibility of 'on-demand' production of selected drugs to cover their demand for a time window of 90 days. We focused on two sub-processes 'automated chemical synthesis' and 'formulation in micropellets' to enable personalized dosing. The production of drugs 'on-demand' is challenging, important, but also attractive. Switzerland could thus gain access to an additional instrument for increasing resilience for supply-critical drugs. The biggest challenge in the case study presented here is the scalability of automated chemical synthesis and the application range of micropellet formulations.

Understanding discourse connectives is an important step to achieving effective verbal communication. Yet, the ability of adult native speakers to understand the broad range of connectives found in most Indo-European languages has seldom been assessed. In this article we demonstrate that some adults have difficulties recognizing correct and incorrect uses of connectives in their native language. In Experiment 1 we show that adults have a lower ability to understand less frequently used connectives from the written mode than more frequently used ones. We also report that such an ability depends on participants' exposure to print (as measured by the Author Recognition Test), in turn correlating with higher general grammatical competence. In Experiment 2 we find that the performance of an adult increases with connectives that are used in both speech and writing, although differences are still present between connectives and between participants differently exposed to print. We conclude that connectives represent an area of complexity for some adults with less exposure to print and poorer grammatical competences.

ABSTRACT: Milking stall dimensions have not been adapted to the increase in cow body size caused by selection for better milking performance over the past decades. Improper milking stall dimensions might limit cow comfort, could lead to stress responses during milking and thus could negatively affect cow welfare. A crossover study was conducted in an experimental milking parlor that was converted from a herringbone (HB) to a side-by-side (SBS) parlor. The milking stall dimensions were modified in length and width and for HB also in depth (perpendicular distance between rump rail and breast rail). The stall dimensions applied during the experiments ranged from much smaller than common in European dairy farming to much larger. Treatments were applied for 2 wk per milking parlor type. In each milking parlor type, a total of 30 cows, kept in 2 groups were observed during milking for behavioral and physiological stress responses and for milking performance. In addition, milk cortisol levels and somatic cell counts were measured at the end of the 2-wk period. Outcome variables were selected based on a principal component analysis and analyzed using mixed effects models reflecting the experimental design. The results showed that the first cow per milking batch required more time (on average >40 s) to enter very small HB stalls than to enter small, large and very large stalls (

Experimental procedures involving farm animals are often associated with stress due to restraining. Stress can be reduced through use of positive reinforcement training, which then serves as refinement according to the 3Rs principles. Trainer skills, however, may influence the feasibility and success of animal training. The potential influence of trainer skills as well as the education of animal trainers are rarely described in literature but are necessary information for the implementation of positive reinforcement training as a refinement measure. To investigate the effect of educational programmes on animal trainers, we compared the training success of two groups of participants in training goats to elicit a behaviour that would allow simulated venipuncture. One group was educated in a two-day workshop while the other was provided with specific literature for self-instructed learning. Training success was evaluated using an assessment protocol developed for this study. A greater training success in the WORKSHOP GROUP, reflected by objective and subjective measures, was clearly supported statistically. In addition, 73 versus only 13% of the participants of the WORKSHOP GROUP and the self-instructed BOOK GROUP, respectively, stated that they could completely implement the knowledge gained in the course of this study. Our results indicate that more intensively educated trainers can train animals more successfully. In conclusion, if animal training is implemented as refinement, animal caretakers should receive instruction for positive reinforcement training.

Research often conceptualises complex social factors as being distinct binary categories (e.g., female vs male, feminine vs masculine). While this can be appropriate, the addition of an 'overlapping' category (e.g., non-binary, gender neutral) can contextualise the 'binary', both for participants (allowing more complex conceptualisations of the categories than the 'either/or' conceptualisation in binary tasks), and for the results (by providing a neutral baseline for comparison). However, it is not clear what the best response setup for such a task would be. In this study, we explore this topic through comparing a unimanual (N = 34) and a bimanual response setup (N = 32) for use with a three-alternative choice response time task. Crucially, one of the stimulus categories ('mixed') was composed of stimulus elements from the other two stimulus categories used in that task (Complex Task). A reference button task was included to isolate the motoric component of response registration (Simple Task). The results of the simple task indicated lower motoric costs for the unimanual compared to the bimanual setup. However, when statistically controlling for these motoric costs in the complex task, the bimanual setup had a lower error rate and faster response times than the unimanual setup. Further, in the complex task error rates and response times were higher for the mixed than the matched stimuli, indicating that responding to mixed stimuli is more challenging for encoding and/or decision making processes. This difference was more pronounced in the unimanual than the bimanual setup. Taken together these results indicate that the unimanual setup is more adequate for the reference button task, whereas the intricacy of overlapping categories in the complex task is better contained in the bimanual setup, i.e. when some response alternatives are allocated to one hand and other alternatives to the other hand.

The perceived gender ratio of 422 role nouns was evaluated by Chinese- ('N' = 80), Finnish- ('N' = 77), and Russian-speaking ('N' = 134) students using an 11-point rating scale with counterbalanced scale anchors. Data were collected online between 2015 and 2019, via a self-administered questionnaire. The dataset contains all role nouns in English together with their Chinese, Finnish, and Russian translations, as well as by-item analyses. The data set expands previous data sets and provides social scientists with gender ratio information when selecting social or occupational roles as stimulus materials for experimentation, especially for cross-linguistic or cross-cultural studies.

Animal pigmentation plays a key role in many biological interactions, including courtship and predator avoidance. Sympatric benthic and limnetic ecotypes of threespine stickleback (Gasterosteus aculeatus) exhibit divergent pigment patterns. To test whether differential predation by cutthroat trout contributes to the differences in pigmentation seen between the ecotypes, we used a within-generation selection experiment on F2 benthic-limnetic hybrids. After 10 months of differential selection, we compared the pigmentation of fish under trout predation to control fish not exposed to trout predation. We found that stickleback exhibited more lateral barring in ponds with trout predation. Ponds with trout were also less turbid, and a greater degree of barring was negatively correlated with the magnitude of turbidity across pond replicates. A more benthic diet, a proxy for habitat use, was also correlated with greater lateral barring and green dorsal pigmentation. These patterns suggest that differential exposure to cutthroat trout predation may explain the divergence in body pigmentation between benthic and limnetic ecotypes.