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173 results on '"Györffy, Balázs A."'

6. The Kerr rotation in the unconventional superconductor Sr$_2$RuO$_4$

Author

Gradhand, Martin, Wysokinski, Karol I., Annett, James F., and Györffy, Balazs L.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

The interpretation of Kerr rotation measurements in the superconducting phase of Sr$_2$RuO$_4$ is a controversial topic. Both intrinsic and extrinsic mechanisms have been proposed, and it has been argued that the intrinsic response vanishes by symmetry. We focus on the intrinsic contribution and clarify several conflicting results in the literature. On the basis of symmetry considerations and detailed calculations we show that the intrinsic Kerr signal is not forbidden in a general multi- band system but has a rich structure in the near infrared regime. We distinguish different optical transitions determined by the superconducting gap (far infrared) and the inter orbital coupling of the normal state (near infrared). We argue that the low frequency transitions do not contribute to the Hall conductivity while only the inter-orbital transitions in the near infrared regime contribute. Finally, we discuss the difficulties to connect the calculations for the optical Hall conductivity to the experimental measurement of the Kerr angle. We will compare different approximations which might lead to conflicting results., Comment: 9 pages, 8 figures, 1 table

Published
2013
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17. Supplementary File 1 from Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer

Author

West, Diana C., primary, Kocherginsky, Masha, primary, Tonsing-Carter, Eva Y., primary, Dolcen, D. Nesli, primary, Hosfield, David J., primary, Lastra, Ricardo R., primary, Sinnwell, Jason P., primary, Thompson, Kevin J., primary, Bowie, Kathleen R., primary, Harkless, Ryan V., primary, Skor, Maxwell N., primary, Pierce, Charles F., primary, Styke, Sarah C., primary, Kim, Caroline R., primary, de Wet, Larischa, primary, Greene, Geoffrey L., primary, Boughey, Judy C., primary, Goetz, Matthew P., primary, Kalari, Krishna R., primary, Wang, Liewei, primary, Fleming, Gini F., primary, Györffy, Balázs, primary, and Conzen, Suzanne D., primary

Published
2023
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18. Supplementary File 2 from Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer

Author

West, Diana C., primary, Kocherginsky, Masha, primary, Tonsing-Carter, Eva Y., primary, Dolcen, D. Nesli, primary, Hosfield, David J., primary, Lastra, Ricardo R., primary, Sinnwell, Jason P., primary, Thompson, Kevin J., primary, Bowie, Kathleen R., primary, Harkless, Ryan V., primary, Skor, Maxwell N., primary, Pierce, Charles F., primary, Styke, Sarah C., primary, Kim, Caroline R., primary, de Wet, Larischa, primary, Greene, Geoffrey L., primary, Boughey, Judy C., primary, Goetz, Matthew P., primary, Kalari, Krishna R., primary, Wang, Liewei, primary, Fleming, Gini F., primary, Györffy, Balázs, primary, and Conzen, Suzanne D., primary

Published
2023
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19. Supplementary Information and Figures from Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer

Author

West, Diana C., primary, Kocherginsky, Masha, primary, Tonsing-Carter, Eva Y., primary, Dolcen, D. Nesli, primary, Hosfield, David J., primary, Lastra, Ricardo R., primary, Sinnwell, Jason P., primary, Thompson, Kevin J., primary, Bowie, Kathleen R., primary, Harkless, Ryan V., primary, Skor, Maxwell N., primary, Pierce, Charles F., primary, Styke, Sarah C., primary, Kim, Caroline R., primary, de Wet, Larischa, primary, Greene, Geoffrey L., primary, Boughey, Judy C., primary, Goetz, Matthew P., primary, Kalari, Krishna R., primary, Wang, Liewei, primary, Fleming, Gini F., primary, Györffy, Balázs, primary, and Conzen, Suzanne D., primary

Published
2023
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20. Supplementary File 3 from Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer

Author

West, Diana C., primary, Kocherginsky, Masha, primary, Tonsing-Carter, Eva Y., primary, Dolcen, D. Nesli, primary, Hosfield, David J., primary, Lastra, Ricardo R., primary, Sinnwell, Jason P., primary, Thompson, Kevin J., primary, Bowie, Kathleen R., primary, Harkless, Ryan V., primary, Skor, Maxwell N., primary, Pierce, Charles F., primary, Styke, Sarah C., primary, Kim, Caroline R., primary, de Wet, Larischa, primary, Greene, Geoffrey L., primary, Boughey, Judy C., primary, Goetz, Matthew P., primary, Kalari, Krishna R., primary, Wang, Liewei, primary, Fleming, Gini F., primary, Györffy, Balázs, primary, and Conzen, Suzanne D., primary

Published
2023
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25. Competitive inhibition of the classical complement pathway using exogenous single-chain C1q recognition proteins

Author

Vadászi, Henrietta, primary, Kiss, Bence, additional, Micsonai, András, additional, Schlosser, Gitta, additional, Szaniszló, Tamás, additional, Kovács, Réka Á., additional, Györffy, Balázs A., additional, Kékesi, Katalin A., additional, Goto, Yuji, additional, Uzonyi, Barbara, additional, Liliom, Károly, additional, and Kardos, József, additional

Published
2022
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26. Transcriptomic mapping of non-small cell lung cancer K-RAS p.G12C mutated tumors: identification of surfaceome targets and immunologic morrelates

Author

Alcaraz Sanabria, Ana, Cabañas Morafraile, Esther, Fernández Hinojal, Gonzalo, Velasco Díez, Guillermo, Pérez Segura, Pedro, Pandiella, Atanasio, Györffy, Balázs, Ocaña, Alberto, Alcaraz Sanabria, Ana, Cabañas Morafraile, Esther, Fernández Hinojal, Gonzalo, Velasco Díez, Guillermo, Pérez Segura, Pedro, Pandiella, Atanasio, Györffy, Balázs, and Ocaña, Alberto

Abstract

Targeting K-RAS-mutant non-small cell lung cancer (NSCLC) with novel inhibitors has shown promising results with the recent approval of sotorasib in this indication. However, progression to this agent is expected, as it has previously been observed with other inhibitors. Recently, new immune therapeutics, including vectorized compounds with antibodies or modulators of the host immune response, have demonstrated clinical activity. By interrogating massive datasets, including TCGA, we identified genes that code for surface membrane proteins that are selectively expressed in K-RAS mutated NSCLC and that could be used to vectorize novel therapies. Two genes, CLDN10 and TMPRSS6, were selected for their clear differentiation. In addition, we discovered immunologic correlates of outcome that were clearly de-regulated in this particular tumor type and we matched them with immune cell populations. In conclusion, our article describes membrane proteins and immunologic correlates that could be used to better select and optimize current therapies., Ministerio de Economía y Competitividad (MINECO)/FEDER, Ministerio de Ciencia e Innovación (MICINN), Instituto de Salud Carlos III (ISCIII), Junta de Comunidades de Castilla-La Mancha, National Research, Development and Innovation Office (Hungary), CRIS Cancer Foundation, Sección Deptal. de Bioquímica y Biología Molecular (Biológicas), Depto. de Medicina, Fac. de Ciencias Biológicas, Fac. de Medicina, TRUE, pub

Published
2022

31. Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice

Author

Kovács, Réka Á., primary, Vadászi, Henrietta, additional, Bulyáki, Éva, additional, Török, György, additional, Tóth, Vilmos, additional, Mátyás, Dominik, additional, Kun, Judit, additional, Hunyadi-Gulyás, Éva, additional, Fedor, Flóra Zsófia, additional, Csincsi, Ádám, additional, Medzihradszky, Katalin, additional, Homolya, László, additional, Juhász, Gábor, additional, Kékesi, Katalin A., additional, Józsi, Mihály, additional, Györffy, Balázs A., additional, and Kardos, József, additional

Published
2021
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45. Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer.

Author

Andrijes, Regina, Hejmadi, Rahul K., Pugh, Matthew, Rajesh, Sundaresan, Novitskaya, Vera, Ibrahim, Maha, Overduin, Michael, Tselepis, Chris, Middleton, Gary W., Györffy, Balázs, and Berditchevski, Fedor

Subjects
COLORECTAL cancer, TETRASPANIN, EPIDERMAL growth factor receptors, CELLULAR signal transduction, EXTRACELLULAR vesicles
Abstract

Early stages of colorectal cancer (CRC) development are characterized by a complex rewiring of transcriptional networks resulting in changes in the expression of multiple genes. Here, we demonstrate that the deletion of a poorly studied tetraspanin protein Tspan6 in Apcmin/+ mice, a well-established model for premalignant CRC, resulted in increased incidence of adenoma formation and tumor size. We demonstrate that the effect of Tspan6 deletion results in the activation of EGF-dependent signaling pathways through increased production of the transmembrane form of TGF-α (tmTGF-α) associated with extracellular vesicles. This pathway is modulated by an adaptor protein syntenin-1, which physically links Tspan6 and tmTGF-α. In support of this, the expression of Tspan6 is frequently decreased or lost in CRC, and this correlates with poor survival. Furthermore, the analysis of samples from the epidermal growth factor receptor (EGFR)-targeting clinical trial (COIN trial) has shown that the expression of Tspan6 in CRC correlated with better patient responses to EGFR-targeted therapy involving Cetuximab. Importantly, Tspan6-positive patients with tumors in the proximal colon (right-sided) and those with KRAS mutations had a better response to Cetuximab than the patients that expressed low Tspan6 levels. These results identify Tspan6 as a regulator of CRC development and a potential predictive marker for EGFR-targeted therapies in CRC beyond RAS pathway mutations. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Epigenetic mutational landscape in breast cancer: role of the histone methyltransferase gene KMT2D in triple negative tumors

Author

Morcillo García, Sara, primary, Noblejas López, María del Mar, additional, Nieto Jiménez, Cristina, additional, Pérez Peña, Javier, additional, Nuncia Cantarero, Miriam, additional, Györffy, Balázs, additional, Amir, Eitan, additional, Pandiella, Atanasio, additional, Galán Moya, Eva María, additional, and Ocaña, Alberto, additional

Published
2018
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50. Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer

Author

West, Diana C., primary, Kocherginsky, Masha, additional, Tonsing-Carter, Eva Y., additional, Dolcen, D. Nesli, additional, Hosfield, David J., additional, Lastra, Ricardo R., additional, Sinnwell, Jason P., additional, Thompson, Kevin J., additional, Bowie, Kathleen R., additional, Harkless, Ryan V., additional, Skor, Maxwell N., additional, Pierce, Charles F., additional, Styke, Sarah C., additional, Kim, Caroline R., additional, de Wet, Larischa, additional, Greene, Geoffrey L., additional, Boughey, Judy C., additional, Goetz, Matthew P., additional, Kalari, Krishna R., additional, Wang, Liewei, additional, Fleming, Gini F., additional, Györffy, Balázs, additional, and Conzen, Suzanne D., additional

Published
2018
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