Search

We consider a macroscopic model for the growth of living tissues incorporating pressure-driven dispersal and pressure-modulated proliferation. Assuming a power-law relation between the mechanical pressure and the cell density, the model can be expressed as the porous medium equation with a growth term. We prove H\"older continuous dependence of the solutions of the model on the diffusion exponent. The main difficulty lies in the degeneracy of the porous medium equations at vacuum. To deal with this issue, we first regularise the equation by shifting the initial data away from zero and then optimise the stability estimate derived in the regular setting.

Several recent papers considered the high-friction limit for systems arising in fluid mechanics. Following this approach, we rigorously derive the nonlocal Cahn-Hilliard equation as a limit of the nonlocal Euler-Korteweg equation using the relative entropy method. Applying the recent result by the first and third author, we also derive rigorously the local degenerate Cahn-Hilliard equation. The proof is formulated for dissipative measure-valued solutions of the nonlocal Euler-Korteweg equation which are known to exist on arbitrary intervals of time. Our work provides a new method to derive equations not enjoying classical solutions via relative entropy method by introducing the nonlocal effect in the fluid equation., Comment: 36 pages + appendix + bibliography

We consider a combined system of Euler--Korteweg and Euler--Poisson equations with friction and exponential pressure with exponent $\gamma > 1$. We show the existence of dissipative measure-valued solutions in the cases of repulsive and attractive potential in Euler--Poisson system. The latter case requires additional restriction on $\gamma$. Furthermore in case of $\gamma \geq 2$ we show that the strong solutions to the Cahn--Hillard--Keller--Segel system are a high-friction limit of the dissipative measure-valued solutions to Euler--Korteweg--Poisson equations.

We propose a new concept of weak solution to the equations of compressible magnetohydrodynamics driven by large boundary data. The system of the underlying field equations is solvable globally in time in the out of equilibrium regime characteristic for turbulence. The weak solutions comply with the weak-strong uniqueness principle; they coincide with the classical solution of the problem as long as the latter exists. The choice of constitutive relations is motivated by applications in stellar magnetoconvection.

This paper presents a mathematical framework for modeling the dynamics of heterogeneous populations. Models describing local and non-local growth and transport processes, dependent on dynamically changing population structures, appear in a variety of applications such as crowd dynamics, tissue regeneration, cancer development, and coagulation-fragmentation processes. The current body of literature regarding mathematical modeling presents common challenges to mathematicians due to the multiscale nature of the structures that underlie self-organisation and control within complex, heterogeneous systems. In various applications, similar, abstract mathematical concepts arise through problem formulation and the assimilation of mathematical depictions into the language of measure evolution on a multi-faceted state space. In view of the above observations, we propose an overarching mathematical framework for nonlinear structured population models on abstract metric spaces, which are only assumed to be separable and complete. To achieve this, we exploit the structure of the space of non-negative Radon measures under the dual bounded Lipschitz distance (flat metric), a generalization of the Wasserstein distance that is capable of addressing non-conservative problems. The formulation of models on generic metric spaces facilitates the study on infinite-dimensional state spaces or graphs with a combination of discrete and continuous structures. This opens up exciting possibilities for modeling single cell data, crowd dynamics or coagulation-fragmentation processes., Comment: corrected introduction

It is well-known that one can construct solutions to the nonlocal Cahn-Hilliard equation with singular potentials via Yosida approximation with parameter $\lambda \to 0$. The usual method is based on compactness arguments and does not provide any rate of convergence. Here, we fill the gap and we obtain an explicit convergence rate $\sqrt{\lambda}$. The proof is based on the theory of maximal monotone operators and an observation that the nonlocal operator is of Hilbert-Schmidt type. Our estimate can provide convergence result for the Galerkin methods where the parameter $\lambda$ could be linked to the discretization parameters, yielding appropriate error estimates.

We consider the Navier-Stokes-Fourier system describing the motion of a compressible viscous fluid in a container with impermeable boundary subject to time periodic heating and under the action of a time periodic potential force. We show the existence of a time periodic weak solution for arbitrarily large physically admissible data.

We consider the system of equations describing the flow of incompressible fluids in bounded domain. In the considered setting, the Cauchy stress tensor is a monotone mapping and has asymptotically $(s-1)$-growth with the parameter $s$ depending on the spatial and time variable. We do not assume any smoothness of $s$ with respect to time variable and assume the log-H\"{o}lder continuity with respect to spatial variable. Such a setting is a natural choice if the material properties are instantaneously, e.g. by the switched electric field. We establish the long time and the large data existence of weak solution provided that $s\ge(3d+2)(d+2)$.

We consider several pressureless variants of the compressible Euler equation driven by nonlocal repulsionattraction and alignment forces with Poisson interaction. Under an energy admissibility criterion, we prove existence of global measure-valued solutions, i.e., very weak solutions described by a classical Young measure together with appropriate concentration defects. We then investigate the evolution of a relative energy functional to compare a measure-valued solution to a regular solution emanating from the same initial datum. This leads to a (partial) weak-strong uniqueness principle.

We consider the multi-dimensional generalization of the Aw-Rascle system for vehicular traffic. For an arbitrary large class of initial data and the periodic domain, we prove the existence of global-in-time measure-valued solutions. Moreover, using the relative energy technique, we show that the measure-valued solutions coincide with the classical solutions as long as the latter exist., Comment: Typographical errors coorected

For a class of functionals having the $(p,q)$-growth, we establish an improved range of exponents $p$, $q$ for which the Lavrentiev phenomenon does not occur. The proof is based on a standard mollification argument and Young convolution inequality. Our contribution is two-fold. First, we observe that it is sufficient to regularise only bounded functions. Second, we exploit the $L^{\infty}$ bound on the function rather than the $L^p$ estimate on the gradient. Our proof does not rely on the properties of minimizers to variational problems but it is rather a consequence of the underlying Musielak-Orlicz function spaces. Moreover, our method works for unbounded boundary data, the variable exponent functionals and vectorial problems. In addition, the result seems to be optimal for $p\le d$., Comment: 32 pages

We consider the physically relevant fully compressible setting of the Rayleigh Benard problem of a fluid confined between two parallel plates, heated from the bottom, and subjected to the gravitational force. Under suitable restrictions imposed on the constitutive relations we show that this open system is dissipative in the sense of Levinson, meaning there exists a bounded absorbing set for any global-in-time weak solution. In addition, global-in-time trajectories are asymptotically compact in suitable topologies and the system possesses a global compact trajectory attractor A. The standard technique of Krylov and Bogolyubov then yields the existence of an invariant measure - a stationary statistical solution sitting on A. In addition, the Birkhoff - Khinchin ergodic theorem provides convergence of ergodic averages of solutions belonging to A a.s. with respect to the invariant measure.

We obtain an existence result for a Measure Differential Equation with an additional nonlinear growth/decay term that may change the sign. The proof requires a modification of approximating schemes proposed by Piccoli and Rossi. The new scheme combines model discretisation with the exponential solution of the nonlinear growth/decay and hence preserves nonnegativity of the measure. Furthermore, we formulate a simpler analytic condition on the Measure Vector Field which substantially simplifies the previous proof of continuity of solutions with respect to initial data., Comment: 25 pages + appendix + references

From a systems biology perspective the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental data. Having this in mind, in this paper, we aim at contributing to the improvement of many cancer models which contain a proliferation term. To this end, we propose a new non-local model of cell proliferation. We select data which are suitable to perform a Bayesian inference for unknown parameters and we provide a discussion on the range of applicability of the model. Furthermore, we provide proof of the stability of a posteriori distributions in total variation norm which exploits the theory of spaces of measures equipped with the weighted flat norm. In a companion paper, we provide a detailed proof of the well-posedness of the problem and we investigate the convergence of the EBT algorithm applied to solve the equation.

We consider the EBT algorithm (a particle method) for the non-local equation with a discontinuous interaction kernel. The main difficulty lies in the low regularity of the kernel which is not Lipschitz continuous, thus preventing the application of standard arguments. Therefore, we use the radial symmetry of the problem instead and transform it using spherical coordinates. The resulting equation has a Lipschitz kernel with only one singularity at zero. We introduce a new weighted flat norm and prove that the particle method converges in this norm. We also comment on the two-dimensional case which requires the application of the theory of measure spaces on general metric spaces and present numerical simulations confirming the theoretical results. In a companion paper, we apply the Bayesian method to fit parameters to this model and study its theoretical properties.

We show that weak solutions of general conservation laws in bounded domains conserve their generalized entropy, and other respective companion laws, if they possess a certain fractional differentiability of order 1/3 in the interior of the domain, and if the normal component of the corresponding fluxes tend to zero as one approaches the boundary. This extends various recent results of the authors.

We consider a perturbation in the non-linear transport equation on measures i.e. both initial condition $\mu_0$ and the solution $\mu_t^h$ are bounded Radon measures $\mathcal{M}(\mathbb{R}^d)$. The perturbations occur in the velocity field and also in the right-hand side scalar function. It is shown that the solution is differentiable with respect to the perturbation parameter $h$ i.e. that derivative is an element of a proper Banach space. This result extends our previous result which considered the linear transport equation. The proof exploits approximation of the non-linear problem which is based on the study of the linear equation.

We study the elliptic inclusion given in the following divergence form \begin{align*} & -\mathrm{div}\, A(x,\nabla u) \ni f\quad \mathrm{in}\quad \Omega, & u=0\quad \mathrm{on}\quad \partial \Omega. \end{align*} As we assume that $f\in L^1(\Omega)$, the solutions to the above problem are understood in the renormalized sense. We also assume nonstandard, possibly nonpolynomial, heterogeneous and anisotropic growth and coercivity conditions on the maximally monotone multifunction $A$ which necessitates the use of the nonseparable and nonreflexive Musielak--Orlicz spaces. We prove the existence and uniqueness of the renormalized solution as well as, under additional assumptions on the problem data, its relation to the weak solution. The key difficulty, the lack of a Carath\'{e}odory selection of the maximally monotone multifunction is overcome with the use of the Minty transform.

We consider a parabolic PDE with Dirichlet boundary condition and monotone operator $A$ with non-standard growth controlled by an $N$-function depending on time and spatial variable. We do not assume continuity in time for the $N$-function. Using an additional regularization effect coming from the equation, we establish the existence of weak solutions and in the particular case of isotropic $N$-function, we also prove their uniqueness. This general result applies to equations studied in the literature like $p(t,x)$-Laplacian and double-phase problems.

Models of tissue growth are now well established, in particular in relation to their applications to cancer. They describe the dynamics of cells subject to motion resulting from a pressure gradient generated by the death and birth of cells, itself controlled primarily by pressure through contact inhibition. In the compressible regime we consider, when pressure results from the cell densities and when two different populations of cells are considered, a specific difficulty arises from the hyperbolic character of the equation for each cell density, and to the parabolic aspect of the equation for the total cell density. For that reason, few a priori estimates are available and discontinuities may occur. Therefore the existence of solutions is a difficult problem. Here, we establish the existence of weak solutions to the model with two cell populations which react similarly to the pressure in terms of their motion but undergo different growth/death rates. In opposition to the method used in the recent paper of J. A. Carrillo, S. Fagioli, F. Santambrogio, and M.Schmidtchen, Splitting schemes & segregation in reaction-(cross-)diffusion systems, our strategy is to ignore compactness on the cell densities and to prove strong compactness on the pressure gradient. We improve known results in two directions; we obtain new estimates, we treat higher dimension than 1 and we deal with singularities resulting from vacuum.

The aim of this work is to extend and prove the Onsager conjecture for a class of conservation laws that possess generalized entropy. One of the main findings of this work is the "universality" of the Onsager exponent, $\alpha > 1/3$, concerning the regularity of the solutions, say in $C^{0,\alpha}$, that guarantees the conservation of the generalized entropy; regardless of the structure of the genuine nonlinearity in the underlying system.

We consider a linear perturbation in the velocity field of the transport equation. We investigate solutions in the space of bounded Radon measures and show that they are differentiable with respect to the perturbation parameter in a proper Banach space, which is predual to the H\"older space $\mathcal{C}^{1+\alpha}(\mathbb{R}^d)$. This result on differentiability is necessary for application in optimal control theory, which we also discuss.