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Background. The teacher needs to analyse and promptly make changes in each student’s dosage of physical activity in the class. At the same time, students within the group differ from each other in gender, age, physical fitness and health level. Such differences make it difficult to clearly discern the individual characteristics of every student and thus to help them develop their physical data in the best way, choose a proper motor regime to improve their health. The aim of the work is to calculate and analyse the physical health index for 1st-year students of the 2023-2024 academic year at the Russian New University in scores in order to control their physical condition in the discipline “Physical Culture”. Materials and methods. The survey used the methods, tests and computer programmes developed by the Association “People’s Sports Park”. The Association “People’s Sports Park” has a patent of the Russian Federation No. 2147208 for the “Method of assessing physical health reserves and working capacity of the population” and the ownership right to the computer programme processing and evaluating testing results for different categories of the population. Materials of the research: data from 15 tests for the following human body systems: cardiovascular, respiratory, muscular, nervous. The tests include measurements made both in the state of relative dormancy and in dynamics. The main method of working with the obtained data was their statistical processing and analysis of its results. Results. The article reflects the findings of the study of the first-year students’ heart rhythm obtained with the use of technical means and recorded in real time. The calculation of the physical health index (PHI) of the first-year students made in the 2023-2024 academic year showed the following distribution: • 34% of the students scored between 3 and 3.9 out of 6 points maximum and have a satisfactory level of health and performance ability; • 41% of the first-year students have an unsatisfactory physical condition, which corresponds to 2.0-2.9 points out of 6 maximum; • 25% of the first-year students have good and excellent health levels, which corresponds to 4-6 points; • 75% of the first-year students have a quality of health that requires perfection and maximum control by specialists.

Introduction. The relevance of the article is determined by the importance of assessing the determinants of fertility to determine the possible prospects for its change and the correct justification of the directions and measures of demographic policy aimed at increasing it. The aim of the study is to identify the determinants of fertility decline in the Republic of Tatarstan in 2020‒2022 in comparison with the pre-pandemic period and to predict their impact. Materials and Methods. The authors have calculated and analyzed the dynamics of age-specific fertility rates in the Republic of Tatarstan. The influence of the structural factor and the factor of birth intensity, as well as the indirect factor ‒ age-specific marriage rates ‒ was estimated. Using the method of age movement, the dynamics of fertility and the impact of these factors on it up to 2042 were forecasted. Results. The decrease in the total fertility rate in the Republic of Tatarstan in 2020‒2022 was due to changes in the sex and age structure of the population. The excess of the total fertility rate of the region over the indicators of the Volga Federal District and the Russian Federation is due to higher total coefficients for first and second births. The difference between the average number of first births for real generations and for calendar years is determined by temporal shifts associated with postponement of first births due to late entry into first marriage and registered marriages. Discussion and Conclusion. It is predicted that the number of young people will decrease until 2028 and the number of births until 2031. The negative impact of the factor of the gender and age structure of the population will last until 2030, in the 2030s the structural factor will contribute to an increase in the overall fertility rate. The research results presented in the article can be used to determine hypotheses regarding fertility prospects when developing forecasts for demographic and socio-economic development. Correct assessment of the determinants of fertility provides grounds for the development of effective measures of demographic policy with regard to fertility.

The aim of the study was to evaluate the data of phylogenetically analyzed nucleotide sequences from the K. pneumoniae strain uge genes carried out in the perinatal center. Materials and methods. Fifty-six sequences of the K. pneumoniae uge gene were analyzed. The uge gene was detected by real-time PCR using DT light amplifier (Russia). Results. The rate of K. pneumoniae strains among patients of obstetric and gynecological departments in 2020–2023 averaged 1.4%. In pediatric hospitals, the isolation of K. pneumoniae strains comprised 12–14% in 2020, 2021 and 2023. In 2022, a fourfold decrease in detected K. pneumoniae strains was recorded. Phylogenetic analysis showed that the nucleotide sequences were significantly grouped into 14 clusters. The K. pneumoniae virulence factor uge gene is found in 64.3% cases. The nucleotide sequences allowed to detect heterogeneous K. pneumoniae strain population isolated from patients at the perinatal center from 2019 to 2023 analyzed by the phylogenetic method. There are clusters that combine K. pneumoniae genovariants isolated in 2019 and not replenished with new isolates, which confirms the effectiveness of ongoing anti-epidemic measures, enhanced during COVID-19 spread, excluding the transmission of an infectious agent from a source to a susceptible organism in nosocomial environment. P249Q, N279L amino acid substitutions within the uge gene were determined, which distinguish hypervirulent strains from those with a lower degree of pathogenicity. Out of five mother-child pairs, in four — nucleotide sequences of K. pneumoniae strain uge gene were genetically closer to each other than to other strains isolated from patients of the Medical Departments suggesting about a high degree of their relationship, highly likely indicating that the source of the strain for the child was the paired mother, and not the patients of the departments or the staff of the institution. In one mother-child pair, K. pneumoniae strains belonged to different clusters. The isolate obtained on 09/06/2021 from neonatal faeces (age: 7 days old) was grouped with strains isolated on 12/12/2020 from a patient in the maternity ward and in Laos in 2013 (CP035196). K. pneumoniae isolated on 06/04/2021 from the urine of a woman, was significantly grouped with strains included in cluster 13. Conclusion. An opportunity for improving local microbiological monitoring by sequencing and phylogenetic analysis of K. pneumoniae uge gene has been demonstrated. Assessment of changes in the intraspecies population pattern of HCAI pathogens is necessary for a timely and reasonable response to the deterioration of the epidemiological situation.

Aim. To evaluate the endometrial microbiota in patients with uterine scar defect after cesarean section. Materials and methods. The study included 80 women of reproductive age. The main group included 50 patients with a uterus scar defect due to cesarean section; the comparison group included 30 women with a competent uterus scar due to cesarean section. Patients underwent a Pipelle endometrial biopsy on days 2022 of the menstrual cycle using a double-lumen catheter that excludes sample contamination with vaginal and cervical microflora. A molecular genetic study of the endometrium was performed by real-time polymerase chain reaction using the Femoflor 16 reagent kit (DNA-Technology Moscow). The DNA content in the specimen was measured using software and expressed in genome equivalent (GE) proportional to the number of microorganisms. The statistical data were processed using the Exсel software package and SPSS Statistics 22.0. Results. The study showed the following statistically significant differences: lower count of Lactobacillus spp. 2.600 (1.4303.600) GE/mL vs 3.550 (2.8004.700) GE/mL in patients of the comparison group (p=0.02); higher count of Streptococcus and Staphylococcus spp. 3.270 (3.0003.700) GE/mL and 3.450 (3.2003.600) GE/mL vs 1.030 (0.7601.700) GE/mL and 0.560 (0.1201.200) GE/mL in the comparison group, respectively (p0.00001); higher count of Enterobacteriaceae 2.700 (1.7003.300) GE/mL vs 0.950 (0.6601.120) GE/mL in the comparison group (p0.00001); higher count of Gardnerella/Prevotellabivia/Porphyromonas spp. 2.310 (0.9303.480) GE/mL vs 1.000 (0.0001.860) GE/mL (p=0.003); higher count of Peptostreptococcus spp. 0.195 (0.0001.560) GE/mL vs 0.000 (0.000-0.000) GE/mL (p=0.032); Eubacterium spp. 1.355 (0.1002.460) GE/mL vs 0.000 (0.0001.560) GE/mL (p=0.040). Conclusion. Endometrial dysbiosis in patients with a uterus scar defect after cesarean section due to the possible effects of microorganisms can be considered one of the leading causes of the formation of a uterus scar defect in the postoperative period.

Introduction. The family forms the habitus of the child's health-preserving behavior: the presence or absence of bad habits, involvement in sports, food preferences, and the attitude to disease prevention. The article, based on the conducted research, identifies the dependence of various parameters of the health of school-age children on the socio-biological well-being of the family, its lifestyle, life support conditions that contribute to the implementation of family health-preserving practices. Materials and Methods. The research materials used were the data from a survey conducted in 2019 by the Center for Family and Demography Center of Tatarstan Academy of Sciences among parents of students of lyceums, grammar schools, and general education schools, including those with in-depth study of specific subjects (city of Kazan, Arsk and Chistopol municipal districts of the Republic of Tatarstan). The total population of parents of students was 433,706 people, the selection was 325 people. The value, social activity, and generation approaches within the sociological discourse on health issues are aimed at identifying the social determinants of various parameters of adolescent health and their health preservation habitus. Results. The study has identified a number of factors that determine the lifestyle of modern schoolchildren and have a negative impact on their health in the context of significant academic loads, intensification of the educational process, and involvement in intense extra-curricular activities: non-compliance with age regulations of the daily routine; low motor activity; unsatisfactory organization and deterioration of the quality of nutrition in the family; habitus of parents’ behavior, not focused on health preservation. Discussion and Conclusion. The conducted research provides scientific substantiation of and emphasizes the need for measures aimed at increasing physical activity and healthy nutrition of both younger and older schoolchildren in the context of the demographic crisis. Practical application of the conclusions drawn in this study involves formulation of proposals for improving the effectiveness of managerial decisions taken by ministries and departments of the Republic of Tatarstan.

A significant increase in human papillomavirus-associated cervical oncological diseases, a high rate of recurrence of the process (4862.4%) after surgical treatment, changes in the local immune microenvironment in cervical biopsy specimens with (HSIL) created the prerequisites for studying the clinical efficacy of local immunocorrection in complex HSIL therapy. Aim. To study the clinical efficacy of local immunocorrection of azoximer with bromide in the complex therapy of cervical intraepithelial neoplasias. Materials and methods. Examination and treatment of 40 patients with HSIL was carried out. The study of the effectiveness of azoximer bromide in complex therapy in patients with cervical intraepithelial neoplasias of a high degree of oncogenic risk was carried out on the basis of an immunohistochemical study of cervicobioptates to markers CD3, CD56, CD20, CD138, M-CSF. Results and discussion. It was revealed that cervical intraepithelial neoplasias of a high degree of oncogenic risk are accompanied by changes in the local immune microenvironment in the epithelium and stroma of neoplastic altered tissues, which may contribute to the development of neoplasia progression. The inclusion of a local immunomodulator azoximer bromide in the complex therapy helped to reduce the recurrence of the process by 2 times, the elimination of the human papillomavirus by 3.5 times relative to the comparison group. Conclusion. 1. In cervico-biopsy specimens of patients with HSIL, there is an increase in the proportion of cells with expression of receptors CD20, CD3, CD138 (in stromal cells) and a decrease in epithelial infiltration with M-CSF, which indicates significant changes in immune homeostasis in cells of the affected epithelium. Based on the results obtained, at the stage of preparation for surgical treatment of patients with HSIL, it is advisable to include local immunocorrection to improve the outcome of therapy. 2. The inclusion of a local immunomodulator azoximer bromide in the complex therapy helped to reduce the recurrence of the process by 2 times, the elimination of the human papillomavirus by 3.5 times, which dictates the need for complex immunomodulation in the treatment of HSIL at the stage of preparation for surgery.

The complex (multiple) corpus of Turkisms that is described in this article is the result of a long-standing study of the Turkic layer of Russian vocabulary, which has been formed in a multicultural language environment. The data obtained during analyzing the Turkic lexical elements from ten academic explanatory dictionaries of the Russian language, published within the period from the 18th century till the 21st century, have been involved. A large number of lexicographic parameters in dictionaries of this type make it possible to create an adequate picture of the functioning of lexical units in the Russian literary language. The study uses descriptive, comparative-contrastive and statistical methods. The article fixes various shifts and changes associated with the functioning of the Turkic vocabulary layer during the period under consideration, in particular phonetic-graphic, grammatical, semantic, functional-stylistic changes. In addition, it analyzes the methods of lexicography (dictionary fixation) of loan words, for example, the features of the historical and etymological description of the Turkisms, which, in turn, enables to reveal various inaccuracies and inconsistencies relating to the dictionary description of Turkic words. In addition, the article discloses the advantages of a complex fund of Turkic borrowings of the Russian language, outlines the prospects and possibilities for its use. The information resource being created allows to fix and generalize the changes, characteristic of this circle of loan words of the Russian language.

This paper is a part of an ongoing attempt to reflect on the ways and results related to developing research competence, which is considered as an urgent issue for contemporary higher education in Russia. The polypragmatic approach, the major approach used to study the issue, is an integrity of dialectic, exploratory, synergetic and competence approaches that ensures success and effectiveness in developing student research competence. The new approach in considering the competence paradigm in teaching Humanities is associated with predomination of the synergetic principles aimed at developing their intellectual level, high-tech skills, and skills useful in making appropriate decisions in situations requiring high level of a person’s inner organization, deep understanding of concepts, and ability to convert the knowledge into competencies. The authors try to prove that to effectively apply the best practice, humanitarians, as professionals, must understand the basis and synergy of research. In this regard, research skills have been looked upon as a part of a curriculum redevelopment process that still needs enhancement. The authors consider Humanities student attitudes towards research with regard to their ability to use theoretical and methodological basis needed to form their research competence, and come to a conclusion that the approach implemented have improved student self-perceived competence in conducting a research project. They also share their opinions and findings on the structure and synergy of developing self-efficacy in self-organization and self-transformation when carrying out a research project. The information and findings may be useful for practitioners in humanitarian higher education institutions, as well as for further development and contribution into the process of upgrading the system of higher education in Russia.

Abstract Background Patients’ comfort level during the injection procedure affects the quality of care. However, the literature does not provide a valid, reliable, and specific measurement tool to measure this level. Objective The present study aimed to develop a valid and reliable measurement tool to determine patients’ comfort levels during the injection procedure. Method The study was designed methodologically. The study data were collected at two Hospitals. The sample consisted of 102 patients in the pilot application stage and 186 patients in the main application stage. The study’s data collection tools were the “Personal Information Form,” “VAS for Comfort,” and the “Comfort Scale for Injection” draft. The obtained data were used for validity and reliability analyses. Validity analyses involved content validity, Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and criterion validity. Reliability was assessed using Cronbach's Alpha and split-half tests. Statistical analyses were performed with SPSS 22 and AMOS. EFA used the KMO test and Bartlett’s Test (KMO = 0.878; p

ABSTRACT Objective: This study aimed to examine the experiences of nursing students learning psychomotor skills during the COVID-19 pandemic, the problems they experienced in this process, and their feelings and needs. Methods: This was a qualitative phenomenological study. The research was analyzed descriptively and thematically. The research was conducted in Erzurum in January 2022. The population of the study consisted of 2nd-year students studying at the Atatürk University Faculty of Nursing in the fall semester of the 2021–2022 academic year. The sample consisted of four second-year undergraduate nursing students selected by the criterion sampling method. The research data were collected with an ‘Introductory Information Form’ and a ‘Semistructured Questionnaire’. The content analysis method was used to evaluate the qualitative data. Results: Four themes and three subthemes were identified as a result of the analysis of the data obtained from the interviews with the students. The main themes are inefficiency, expectations from the instructor, emotions, and active learning. It was determined that inefficiency was categorized under the subthemes of “Problems experienced in online education and the limitation of online education in terms of learning psychomotor skills” and “Reasons for inefficiency”. It was determined that there were no subthemes in the themes of expectations from the instructor and emotions. Active learning was found to be under the subtheme of “Getting more efficiency from homework rather than what the instructors teach”. Conclusions: The online education process was inadequate for learning the psychomotor skills of nursing students.

Background: It is unknown if health-care literacy and social media use of the students affect vaccine preferences during the COVID-19 pandemic. Objectives: The aim of the present research was to detect whether health-care literacy and social media use of the students affect vaccine preferences during the COVID-19 pandemic. Materials and Methods: The universe of the sample consisted of the students of a university in Mus Alparslan University. The sample of the research included students whose last digit of the school number is an odd number. Four hundred and twenty students participated into the study. The data of the study were collected through the “Sociodemographic Characteristics Questionnaire,” “Health Literacy Scale (HLS),” and “Social Media Usage Scale (SMUS).” Results: The total score average of the students on the “HLS” was 42.74 ± 13.85 and the “SMUS” was 21.30 ± 7.38. It was determined that those who have preferred the “Sinovac” vaccine had higher score averages on the “Information Understanding Subdimension” and “HLS” than those who have preferred the Türkovac vaccine. Furthermore, it was determined that the score average of “Continuity Subdimension,” “Competency Subdimension” and “Social Media Use Scale” were higher, and these differences were statistically significant. Conclusion: It was detected that the health literacy (HL) levels of the students were lower and they do not use social media competently. On the other hand, it was determined that social media use and HL affect the vaccine preferences.

The complex (multiple) corpus of Turkisms that is described in this article is the result of a long-standing study of the Turkic layer of Russian vocabulary, which has been formed in a multicultural language environment. The data obtained during analyzing the Turkic lexical elements from ten academic explanatory dictionaries of the Russian language, published within the period from the 18th century till the 21st century, have been involved. A large number of lexicographic parameters in dictionaries of this type make it possible to create an adequate picture of the functioning of lexical units in the Russian literary language. The study uses descriptive, comparative-contrastive and statistical methods. The article fixes various shifts and changes associated with the functioning of the Turkic vocabulary layer during the period under consideration, in particular phonetic-graphic, grammatical, semantic, functional-stylistic changes. In addition, it analyzes the methods of lexicography (dictionary fixation) of loan words, for example, the features of the historical and etymological description of the Turkisms, which, in turn, enables to reveal various inaccuracies and inconsistencies relating to the dictionary description of Turkic words. In addition, the article discloses the advantages of a complex fund of Turkic borrowings of the Russian language, outlines the prospects and possibilities for its use. The information resource being created allows to fix and generalize the changes, characteristic of this circle of loan words of the Russian language. [ABSTRACT FROM AUTHOR]