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1. Hydrogen peroxide signaling modulates neuronal differentiation via microglial polarization and Wnt/β-catenin pathway

Author

Kumral, A., Tufekci, K.U., GENÇ, ŞERMİN, Kiser, C., Engur, D., Ercan, I., Guven, S., Ozhan, G., Micili, SERAP, and Soy, S.

Abstract

OBJECTIVE: Reactive oxygen species (ROS) are generated within the cell and serve as second messengers in fundamental cellular processes under physiologic conditions. Although the deleterious effects of high-level ROS associated with oxidative stress are well established, it is unclear how the developing brain reacts to redox changes. Our aim is to investigate how redox alteration affects neurogenesis and the mechanism that underlies it. MATERIALS AND METHODS: We investigated in vivo microglial polarization and neurogenesis in zebrafish after hydrogen peroxide (H2O2) incubation. To quantify intracellular H2O2 levels in vivo, a transgenic zebrafish line that expresses Hyper and termed Tg(actb2:hyper3)ka8 was used. Then, in vitro studies with N9 microglial cells, 3-dimensional neural stem cell (NSC)-microglia coculture, and conditioned medium experiments are carried out to comprehend the mechanism underlying the changes in neurogenesis upon redox modulation. RESULTS: In zebrafish, exposure to H2O2 altered embryonic neurogenesis, induced M1 polarization in microglia, and triggered the Wnt/β-catenin pathway. N9 microglial cell culture experiments revealed that exposure to H2O2 resulted in M1 polarization in microglial cells, and this polarization was mediated by the Wnt/β-catenin pathway. Redox modulation of microglia interfered with NSC differentiation in coculture experiments. Neuronal differentiation was significantly higher in NSCs cocultured with H2O2-treated microglia when compared to control microglia. Wnt inhibition prevented the effects of H2O2-treated microglia on NSCs. No significant alterations were observed in conditioned medium experiments. CONCLUSIONS: Our findings point to a robust interplay between microglia and neural progenitors influenced by the redox state. Intracellular H2O2 levels can interfere with neurogenesis by altering the phenotypic state of the microglia via the Wnt/β-catenin system.

Published
2023

2. Effects of adding natural additives to whole milk on performance, faecal, and blood parameters in suckling Holstein calves.

Author

Guven, S. and Cimrin, T.

Subjects
*CALVES, *BLOOD cell count, *LEUCOCYTES, *ERYTHROCYTES, *WEIGHT gain, *LACTATION in cattle, *FETAL hemoglobin
Abstract

The aim of this study was to investigate the impact of additives containing organic acids, herbal extracts, and prebiotics to whole milk on the developmental performance and several faecal and blood parameters of Holstein calves during the suckling period. A total of 40 one-day-old Holstein calves were divided randomly categorized into two groups of 20 (10 males and 10 females). For the first three days, both groups were provided with five litres of colostrum daily. Starting from the fourth day, the first group (control) received whole milk, while the second group (NCA) was given milk with a commercial additive of 5 g/L of whole milk. The calves had access to starter feed and water ad libitum. Results indicated the body weight and red blood cell counts of calves in the NCA group showed a substantial increase during the first four weeks, while the occurrence of diarrhoea decreased, compared to the control group. However, no marked differences between the control and NCA groups in terms of intake of concentrate feed, feed conversion ratio, body weight gain, levels of white blood cells, haemoglobin, haematocrit, aspartate aminotransferase, phosphorus, gamma-glutamyl transferase, glucose, calcium, creatinine, cholesterol, triglycerides, faecal levels, or days with diarrhoea were noted. Consequently, it was concluded that adding commercial additives to whole milk had a positive effect on the early development of the digestive system of calves, substantially increasing their body weight in the first four weeks of life and therefore making them more resistant to diseases in this critical period. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Hydrogen peroxide signaling modulates neuronal differentiation via microglial polarization and Wnt/β-catenin pathway.

Author

ENGUR, D., ERCAN, I., KISER, C., TUFEKCI, K. U., SOY, S., MICILI, S. C., OZHAN, G., GUVEN, S., KUMRAL, A., and GENC, S.

Abstract

OBJECTIVE: Reactive oxygen species (ROS) are generated within the cell and serve as second messengers in fundamental cellular processes under physiologic conditions. Although the deleterious effects of high-level ROS associated with oxidative stress are well established, it is unclear how the developing brain reacts to redox changes. Our aim is to investigate how redox alteration affects neurogenesis and the mechanism that underlies it. MATERIALS AND METHODS: We investigated in vivo microglial polarization and neurogenesis in zebrafish after hydrogen peroxide (H2O2 ) incubation. To quantify intracellular H2O2 levels in vivo, a transgenic zebrafish line that expresses Hyper and termed Tg(actb2:hyper3)ka8 was used. Then, in vitro studies with N9 microglial cells, 3-dimensional neural stem cell (NSC)-microglia coculture, and conditioned medium experiments are carried out to comprehend the mechanism underlying the changes in neurogenesis upon redox modulation. RESULTS: In zebrafish, exposure to H2O2 altered embryonic neurogenesis, induced M1 polarization in microglia, and triggered the Wnt/β-catenin pathway. N9 microglial cell culture experiments revealed that exposure to H2O2 resulted in M1 polarization in microglial cells, and this polarization was mediated by the Wnt/β-catenin pathway. Redox modulation of microglia interfered with NSC differentiation in coculture experiments. Neuronal differentiation was significantly higher in NSCs cocultured with H2O2-treated microglia when compared to control microglia. Wnt inhibition prevented the effects of H2O2-treated microglia on NSCs. No significant alterations were observed in conditioned medium experiments. CONCLUSIONS: Our findings point to a robust interplay between microglia and neural progenitors influenced by the redox state. Intracellular H2O2 levels can interfere with neurogenesis by altering the phenotypic state of the microglia via the Wnt/β-catenin system. [ABSTRACT FROM AUTHOR]

Published
2023

7. Evaluation of Work-Related Deaths in Geriatric Population

Author

Hacı Seyit Bölükbaşı, Çağnur Canatan Tecir, Niyazi Burak Şengül, Güven Seçkin Kirci, and Erdal Özer

Subjects
geriatric, worker, work-related death, Medicine (General), R5-920
Abstract

Objective: Worker fatalities is a concept that encompasses all deaths occurring during the execution of a profession, which is undertaken to sustain a person’s livelihood, due to the physical and psychological effects of the work. The aim of this study is to examine various parameters in cases aged 65 and over, aiming to reveal the level, form, and causes of occupational accidents and fatalities in the geriatric population. Through this, the study aims to contribute to the literature by shedding light on the exposure level, form, and causes of occupational accidents and fatalities among the geriatric population. Methods: In this cross-sectional, descriptive study, a retrospective analysis was conducted on 86 cases of work-related deaths among the population aged 65 and over in Turkey in 2020, which were reported in the national print and visual media. Results: Of the examined 86 worker fatalities, it was found that 77.9% (n=67) were in the age range of 65-74 years, 88.4% (n=76) of the cases were male, and accidents were the leading cause of death in 72.1% (n=62) of cases. When examined in terms of location distribution, it was found that 43.0% (n=37) occurred in rural areas. Conclusion: In our country, the number of individuals in the geriatric population participating in the workforce is higher compared to developed countries. Consequently, occupational fatalities among the geriatric workforce are also higher. Policies implemented in Europe and America for the aging workforce should be observed, and regular health check-ups should be ensured.

Published
2024
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11. How do endoscopic bladder tumor resection techniques affect pathology practice? EAU Section of Uro-Technology (ESUT) and Uropathology (ESUP) survey

Author

Guven, S., primary, Colecchia, M., additional, Oltulu, P., additional, Bonfante, G., additional, Enikeev, D., additional, Esen, H., additional, Herrmann, T., additional, Lusuardi, L., additional, Micali, S., additional, Somani, B., additional, Skolarikos, A., additional, Breda, A., additional, Liatsikos, E., additional, Redorta, J.P., additional, and Gozen, A.S., additional

Published
2022
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13. Could retrograde intrarenal surgery be a safe and effective alternative to mini percutaneous nephrolithotomy in the management of relatively large (20-30 mm) stones? A critical evaluation

Author

Ibis, M.A., primary, Gokce, M.I., additional, Babayigit, M., additional, Yitgin, Y., additional, Karagoz, M.A., additional, Boyuk, A., additional, Verep, S., additional, Turan, S., additional, Tefik, T., additional, Kiremit, M.C., additional, Sonmez, M.G., additional, Ergul, R., additional, Guven, S., additional, and Sarica, K., additional

Published
2022
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26. Gynecologic oncology

Author

Oskav-Özcelik G., Hindenburg H. J., Klare P., Könsgen D., Mustea A., Heinrich G., Camara O., Lichtenegger W., Sehouli J., Tutuncu L., Ergur A. R., Gul I., Ertekin A., Yergok Y. Z., Ornek T., Tulunay G., Fetiel A., Tan O., Kose F., Haberal A., Noftolin F., Yermez E., Ata N., Sanci M., Sekü I., Karanfil C., Ispahi C., Akar M. E., Simsek T., Tamburaci E., Erdogan G., Pestereli E., Ingec M., Kadanali S., Erdogan F., Naki M. M., Tekcan C., Ergüler Y. S., Uysal A., Songülalp S., Kanadikirik F., Gezginc K., Görkemli H., Celik C., Acar A., Colakoglu M. C., Capar M., Akyürek C., Özbay K., Yardim T., Kurt S., Pilanci B., Tinar S., Camuzcuoglu H., Dicle N., Hanhan M., Inal M., Öztekin D., Dicle N., Özsaran Z., Tinar S., Demir B., Demir S., Gul T., Erden A. C., Bozaci E. A., Atabekoglu C., Taskin S., Sertcelik A., Ünlü C., Ortac F., Taskin S., Cengiz B., Bozaci E. A., Seval M., Ortac F., Taskin S., Yarci A., Kahraman K., Özmen B., Güngör M., Taskin S., Kahraman K., Özmen B., Yarci A., Güngör M., Taskin S., Bozaci E. A., Yarci A., Atabekoglu C., Ortac F., Hascalik S., Celik O., Ustun Y., Erdem G., Karadag N., Alkan A., Karakas H. M., Usta U., Mizrak B., Güzin K., Tekcan C., Naki M. M., Kayatas Eser S., Zemheri E., Kanadikirik F., Kurt S., Öztekin D., Karalti O., Inal M., Özsaran Z., Dicle N., Gunaydin G., Onan A., Taskiran C., Turp A., Yilmaz E., Kurdoglu M., Bozdayi G., Himmetoglu O., Kurdoglu Z., Gultekin M., Dursun P., Celik N. Y., Boynukalin K., Yuce K., Ayhan A., Dursun P., Gultekin M., Celik N. Y., Velipasaoglu M., Yuce K., Ayhan A., Gultekin M., Dursun P., Bozdag G., Celik N. Y., Guler Z., Yuce K., Ayhan A., Erkan L., Soylu F., Oztekin O., Tatli O., Eraslan T., Uysal D., Yavuzcan A., Yensel U., Baloglu A., Yildiz A., Köksal A., Tatli Ö., Tatli O., Ivit H., Yetimalar H., Cukurova K., Simsek E., Haydardedeoglu B., Asian E., Bulgan Kilicdag E., Erkanli S., Ozyurtseven Tarim E., Güzin K., Kayatas S., Tekcan C., Zemheri E., Kayabasoglu F., Kanadikirik F., Özmen B., Taskin S., Ünlü C., Ortac F., Uysal D., Aydin C., Yavuzcan A., Baloglu A., Salman M. C., Otegen U., Ozyuncu O., Bozdag G., Ayhan A., Salman M. C., Guven S., Ozyuncu O., Bozdag G., Usubutun A., Ayhan A., Oztekin D., Kurt S., Tinar S., Mit T., Balsak D., Hanhan M., Kurt S., Oztekin D., Tinar S., Karalti O., Inal M., Seyhan S., Turan T., Altinbas S., Boran N., Ozgul N., Ozer S., Ozfuttu A., Kose M. F., Boran N., Hizli D., Turan T., Halici F., Koc S., Bulbul D., Köse M. F., Vural M., Barut A., Tanriverdi H. A., Tutuncu L., Ergur A. R., Sancaktar M., Ertekin A., Yergok Y. Z., Iyibozkurt A. C., Topuz S., Bengisu E., Ilhan R., Berkman S., Boran N., Sarici S., Kose M. F., Tulunay G., Koc S., Ocalan R., Cavusoglu D., Haberal A., Boran N., Karacay Ö., Öztürkoglu E., Turan T., Cil A., Otken O. F., Köse M. F., Turan T., Öztürk F., Karacay Ö., Boran N., Özgül N., Tulunay G., Erdogan Z., Köse M. F., Koc S., Otken H., Yüksel K., Özdal B., Güngör T., Taner D., Tarhan I., Reyhan H., Aydogdu T., Mollamahmutoglu L., Daylan B. H., Zergeroglu S., Tunc I., Kahraman N., Gungor T., Bilge U., Güngör T., Yüksel K., Reyhan H., Aytan H., Tug M. T., Aydogdu T., Özdal B., Güngör T., Tug M., Cavkaytar S., Güngör T., Aydogdu T., Özdal B., Reyhan H., Daylan H. B., Tune I., Koc Ö., Gözübüyük S., Seckin S., Özdemir T., Abali R., Bozkurt S., Arikan I., Arikan D., Sahin A., Erdener O., Tülay Ö., Ergin S., Midilli K., Tan O., Kose F., Fatial A., Ornek T., Luk J., Tulunay G., Haberal A., Neftolin F., Aslan E., Kilicdag E., Bolat F., Erkanli S., Bal N., Kuscu E., Simsek E., Ayar A., Güzel Y., Vural M., Yetimalar M. H., Zeteroglu U., Köksal A., Soylu F., and Zeteroglu S.

Published
2005
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27. General gynecology

Author

Salfelder A., Lueken R. P., Bormann C., Gallinat A., Moeller C. P., Busche D., Nugent W., Krueger E., Nugent A., Caglar G., Tasci Y., Kayikcioglu F., Haberal A., Hasskamp Th., Krichbaum M., Aka N., Köse G., Sabah G., Sayharman E. S., Kumru P., Aka N., Karaca K., Köse G., Kumru P., Sayharman E. S., Haydardedeoglu B., Simsek E., Kilicdag E., Tarim E., Bagis T., Dede F. S., Dilbaz B., Dede H., Ilhan A. K., Haberal A., Dede F. S., Dilbaz B., Oral S., Erten A., Ilhan A. K., Haberal A., Ertas I. E., Kahyaoglu S., Turgay I., Tug M., Kalyoncu S., Batioglu S., Zorlu G., Arici C., Akar M. E., Ari E. S., Ari E., Erbay O. U., Caliskan M. O., Akar M. E., Simsek M., Taskm O., Gümüs Il., Turhan N. O., Arikan G., Giuliani A., Kelekci S., Yorgancioglu Z., Yilmaz B., Yasar L., Savan K., Sonmez S., Kart C., Vural M., Tanriverdi H. A., Cinar E., Barut A., Özbay K., Yardim T., Demir B., Kilinc N., Gul T., Erden A. C., Turgay I., Kahyaoglu S., Kokanali M. K., Batioglu S., Haydardedeoglu B., Simsek E., Kilicdag E. B., Tarim E., Aslan E., Bagis T., Seval M., Taskin S., Özmen B., Kahraman K., Yarci A., Tasci T., Unlü C., Taskin S., Seval M., Özmen B., Kahraman K., Gözükücük M., Kurt S., Unlü C., Taskin S., Özmen B., Bozaci E. A., Seval M., Ortac F., Yasar L., Sönmez A. S., Zebitay A. G., Gezer N., Yazicioglu H. F., Mehmetoglu G., Dede F. S., Dilbaz B., Kocak M., Dede H., Haberal A., Erten A., Ilhan A. K., Algül Y. L., Erden A. C., Yasar L., Zebitay A. G., Ozcan J., Duman O., Sonmez S., Yazicioglu F., Sensoy Y., Koc S., Cebi Z., Yasar L., Zebitay A. G., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Cebi Z., Zebitay A. G., Yasar L., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Koc S., Cebi Z., Zebitay A. G., Yasar L., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Cebi Z., Simsek M., Mendilcioglu I., Özekinci M., Ulukus M., Ulukus E. C., Seval Y., Cinar O., Zheng W., Arici A., Erkan L., Soylu F., Tatli O., Ozkent V., Dilbaz B., Ilhan A. K., Oral S., Dede H., Dogan A. R., Gün I., Erdemoglu E., Sargin H., Kamaci M., Dede F. S., Erten A., Sendag F., Akman L., Yucebilgin S., Karadadas N., Oztekin K., Bilgin O., Topuz S., Cigerli E., Iyibozkurt C. A., Akhan E. S., Saygili H., Berkman S., Bezircioglu I., Karakaya E., Baran N., Baloglu A., Aydin C., Hizli N., Cetinkaya B., Kavas A., Baloglu A., Cukurova K., Köksal A., Yetimalar H., Yildiz A., Ivit H., Keklik A., Pinar F., Aka N., Köse G., Tosun N., Kumru P., Tuncel T., Boynukalin K., Salman M. C., Ozyuncu O., Bozdag G., Ayhan A., Ates U., Usta T., Seyhan A., Ata B., Sidal B., Guler O. T., Salman M. C., Bozdag G., Ozyuncu O., Esin S., Ozyuncu O., Salman M. C., Bozdag G., Guven S., Gürban A., Gürban G., Özen S., Kirecci A., Özkesici B., Yücel S., Süer N., Erdemoglu E., Gün I., Sargin H., Erdemoglu C. E., Kamaci M., Akhan S. E., Citil I., Topuz S., Iyibozkurt C., Kesim M. D., Atis A., Aydin Y., Özpak D., Tashan F., Zeteroglu S., Kolusari A., Altunay H., Sahin H. G., Kamaci M., Kayikcioglu F., Erol O., Sarici S., Haberal A., Dingiloglu B. S., Güngör T., Özdal B., Cavkaytar S., Bilge Ü., Mollamahmutoglu L., Toprak Konca M., Özsoy S., Hekim N., Özel E., Senates M., Yener C., Göker N., Caliskan E., Filiz T., Yucesoy G., Coskun E., Vural B., Corakci A., Narin M. A., Caliskan E., Kayikcioglu F., Haberal A., Meydanli M. M., Kamaci M., Sahin H. G., Kolusari A., Yildizbas B., Bolluk G., Ates U., Usta T., Ata B., Seyhan A., Ozdemir B., Sidal B., Ünlü B. S., Aytan H., Evsen S., Tapisiz Ö L., Zergeroglu S., Zeteroglu S., Sahin H. G., Guler A., Kolusari A., Kamaci M., Altay M. M., Can A., Ungormus A., Polat A., and Haberal A.

Published
2005
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40. A linear programming model for bank balance sheet management

Author

Guven, S. and Persentili, E.

Subjects
Financial statements -- Management, Banking industry -- Planning, Linear programming -- Usage, Branch banks -- Turkey, Liquidity (Finance) -- Research, Risk management -- Analysis, Business, Business, general
Abstract

Bank balance-sheet management which involves the determination of the size and composition of a bank's assets and liabilities over a multiperiod planning horizon is one of the most prominent issues in bank strategic planning. Not only management policy choices, but legal restrictions and minimum safety requirements, dictated by the economic and political environment operated in, mean a balance has to be struck between the conflicting objectives of profitability, liquidity and risk. Bank balance-sheet management is further complicated by the fact that decisions made at any point in time affect profits, liquidity and risk, not only at the time they are made, but in the periods that follow. This paper discusses a multiperiod linear programming model constructed for a commercial bank in Turkey, that takes into consideration this systematic relationship in the legal, financial and institutional setup of Turkey over the period 1987-1990. Sensitivity analysis results demonstrate the relevance of the model for informed policy choice, and the use of the model as a planning tool. Key words - linear programming, banking, policy analysis, balance-sheet management

Published
1997

46. Çöpler (Erzincan, İç-Doğu Anadolu) Porfiri-Epitermal Altın Yatağında Arjilik Alterasyona İlişkin Mineralojik Kanıtlar (Mineralogical Evidences on Argillic Alteration in the Çöpler Porphyry-Epithermal Gold Deposit) (Erzincan, East-Central Anatolia)

Author

Bozkaya, O, Bozkaya, G, Hanilci, N, Guven, S, Banks, DA, and Uysal, T

Abstract

Çöpler porfiri-epitermal altın yatağı, Tetis Alpin-Himalaya orojenik kuşağında açılmalı tektonizma sonucu gelişen orta Eosen yaşlı plütonik sokulumlarla ilişkili bir altın yatağıdır. Plütonik kayaçlar (granodiyorit porfir, diyorit porfir) Geç Paleozoyik-Mesozoyik yaşlı metapelit ve metakarbonat kayaçlar içerisine sokulum yaparak porfiri-epitermal bir Cu-Au yatağı oluşturmuş ve hidrotermal alterasyon zonlarının (potasik, fillik, propilitik, arjilik) gelişimine neden olmuştur. Bu çalışmada, önceki araştırmacılarca yerel ve sınırlı alanda geliştiği belirtilen süperjen alterasyonun aksine, geniş yayılım sunan arjilik alterasyon zonlarının mineralojik-petrografik özelliklerinin ortaya konulması amaçlanmıştır. Bu kapsamda, optik ve taramalı elektron mikroskop (SEM ve SEM-EDS), X-ışınları kırınımı (XRD), O-H izotop jeokimyası ve K/Ar yaş tayini incelemeleri gerçekleştirilmiştir. Aşırı killeşmiş granodiyorit porfirlerde bile, ilksel porfiritik doku izlenebilmekte, ince-kristalli kil ve kuvarslar homojen ve yer yer mikrolaminasyonlar şeklinde gözlenmektedir. Simektit ve karışık-tabakalı illit-simektit (I-S) mineralleri yapraksıtüysü, illit ve kaolinitler levhamsı biçimler sergilemektedir. Kuvars ve jarositler özşekilli kristaller, kristobalitler kurtçuk görünümlü, bu çalışmada ilk kez belirlenen krandallitler ise ince-taneli granüler topluluklar şeklinde gözlenmektedir. Arjilik zona ait örnekler fillik zona yakın iç kesimlerde (ileri arjilik zon) kuvars + I-S, kuvars + krandallit + jarosit ve kristobalit, dış kesimlerde (arjilik zon) ise kuvars + simektit + kaolinit birliktelikleri sergilemektedir. Simektitler dioktahedral bileşime sahiptir (d060

Published
2018

47. Characteristics of Optic Neuropathy in Behcet's Disease

Author

SAİP, Sabahattin, Yaman, A., Keskinoglu, P., Yilmaz, Guven S., Tutkun, Tugal, Bajin, M. S., SİVA, Aksel, AKDAL HALMAGYI, GÜLDEN, Altunrende, B., UYGUNOĞLU, Uğur, Saatci, O., Toydemir, Ertasoglu H., and Akman-Demir, G.

Published
2018

49. Evaluation of Intoxication Case Application to the Child Emergency Department Between 2016-2021

Author

Güven Seçkin Kırcı, Deniz Utku Öztürk, Hacı Seyit Bölükbaşı, Hilal Çakır, and Erdal Özer

Subjects
forensic case, intoxication, child, Medicine (General), R5-920
Abstract

Objective:Cases of intoxication are among preventable public health problems. In this study, it is aimed to evaluate the pediatric patients between the ages of 0-18 who applied to the hospital due to intoxication and to discuss them in the light of national and international literature.Methods:The files of 293 pediatric patient due to intoxication in our pediatric emergency medicine clinic between 2016-2021 were reviewed retrospectively.Results:Of 293 pediatric patients aged 0-18 years, who applied to the pediatric emergency service due to intoxication, 153 (52.22%) were female and 140 (47.78%) were male, attempting suicide, conscious/pleasure use, and drawing attention. When the intoxication cases that occurred were examined, it was determined that the majority of them occurred between the ages of 12-18, and all of the intoxication cases with intention of suicide attempt (n=60) o between the ages of 12-18.Conclusion:Intoxication cases both in our country and in the world are known to be among the preventable causes of death. In terms of preventing these cases, it is important to raise awareness as a result of effective scientific training at the community, family and individual level. In terms of health policies, limiting the sale and use of non-prescription drugs, not keeping the corrosive substances, cleaning agents and insecticides used in the house in areas where children can easily reach, and making the outer packaging of them in a way that cannot be opened easily will make a great contribution in terms of preventing possible accidents.

Published
2023
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50. How Does Deglobalization Affect Economic Growth?

Author

Güven Sevil, Tuba Sevil, Alp Polat, and Deniz Sevinç

Subjects
küreselleşmeden uzaklaşma, kof endeksi, ekonomik büyüme, deglobalization, kof index, economic growth, Finance, HG1-9999
Abstract

The current global landscape has been marked by a series of factors, such as the US-China trade war, disintegration in the European Union (EU), the refugee crisis, and the pandemic, which have impeded the process of globalization. However, similar situations have been experienced in the past, such as colonization, the Great Depression, and the Cold War. The world has experienced periods of globalization (Globalization I, II, and III) as well as periods of deglobalization (Deglobalization I and II). There have been discussions about whether the current decade is experiencing deglobalization and its effects. In this context, the present study aims to investigate the effects of deglobalization on economic growth in 34 OECD countries during the period 2000-2019, in various dimensions. Using panel data analysis, the results indicate that trade and social deglobalization have a negative impact on economic growth, while financial deglobalization and the subdimensions of social deglobalization have a positive influence on growth. Additionally, the study reveals that political globalization is not significantly associated with economic growth. These findings contribute to the ongoing debate on the current state of globalization and its effects on economic development.

Published
2023
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