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138 results on '"Gutiérrez Junquera, Carolina"'

1. Determinant factors for first-line treatment choice and effectiveness in pediatric eosinophilic esophagitis: an analysis of the EUREOS EoE CONNECT registry

Author

Navarro, Pilar, Feo‐Ortega, Sara, Casabona‐Francés, Sergio, Gutiérrez‐Junquera, Carolina, Savarino, Edoardo V., Amorena, Edurne, Fernández‐Fernández, Sonia, Pérez‐Martínez, Isabel, Oliva, Salvatore, Barrio, Jesús, Masiques‐Mas, Maria Lluisa, Guardiola‐Arévalo, Antonio, Guagnozzi, Danila, Racca, Francesca, Betoré, Elena, Votto, Martina, Rodríguez-Sánchez, Alba, Barrio, Mónica Llorente, Blas‐Jhon, Leonardo, Sánchez‐Vegazo, Carlos Teruel, García-Morales, Natalia, Krarup, Anne Lund, Dainese, Raffaella, Martín‐Dominguez, Verónica, García-Díaz, Alejandro, Maniero, Daria, Santander, Cecilio, Arias, Ángel, Laserna‐Mendieta, Emilio J., and Lucendo, Alfredo J.

Published
2024
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2. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Author

Dellon, Evan S., Gonsalves, Nirmala, Abonia, J. Pablo, Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Attwood, Stephen E., Auth, Marcus K.H., Bailey, Dominique D., Biederman, Luc, Blanchard, Carine, Bonis, Peter A., Bose, Paroma, Bredenoord, Albert J., Chang, Joy W., Chehade, Mirna, Collins, Margaret H., Di Lorenzo, Carlo, Dias, Jorge Amil, Dohil, Ranjan, Dupont, Christophe, Falk, Gary W., Ferreira, Cristina T., Fox, Adam T., Genta, Robert M., Greuter, Thomas, Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Horsley-Silva, Jennifer L., Ishihara, Shunji, Ishimura, Norihisa, Jensen, Elizabeth T., Gutiérrez-Junquera, Carolina, Katzka, David A., Khoury, Paneez, Kinoshita, Yoshikazu, Kliewer, Kara L., Koletzko, Sibylle, Leung, John, Liacouras, Chris A., Lucendo, Alfredo J., Martin, Lisa J., McGowan, Emily C., Menard-Katcher, Calies, Metz, David C., Miller, Talya L., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Murch, Simon, Nhu, Quan M., Nomura, Ichiro, Nurko, Samuel, Ohtsuka, Yoshikazu, Oliva, Salvatore, Orel, Rok, Papadopoulou, Alexandra, Patel, Dhyanesh A., Pesek, Robert D., Peterson, Kathryn A., Philpott, Hamish, Putnam, Philip E., Richter, Joel E., Rosen, Rachel, Ruffner, Melanie A., Safroneeva, Ekaterina, Schreiner, Philipp, Schoepfer, Alain, Schroeder, Shauna R., Shah, Neil, Souza, Rhonda F., Spechler, Stuart J., Spergel, Jonathan M., Straumann, Alex, Talley, Nicholas J., Thapar, Nikhil, Vandenplas, Yvan, Venkatesh, Rajitha D., Vieira, Mario C., von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Wershil, Barry K., Wright, Benjamin L., Yamada, Yoshiyuki, Yang, Guang-Yu, Zevit, Noam, Rothenberg, Marc E., Furuta, Glenn T., and Aceves, Seema S.

Published
2022
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4. Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study

Author

Garcia-Romero, Ruth, Martinez de Zabarte Fernandez, José Miguel, Pujol-Muncunill, Gemma, Donat-Aliaga, Ester, Segarra-Cantón, Oscar, Irastorza-Terradillos, Iñaki, Medina-Benitez, Enrique, Ruiz-Hernández, Carlos José, Carrillo-Palau, Marta, Ros-Arnal, Ignacio, Rodriguez-Martínez, Alejandro, Escartin-Madurga, Laura, Gutiérrez-Junquera, Carolina, Vicente-Santamaría, Saioa, Velasco Rodriguez-Belvis, Marta, Fernández-Fernández, Sonia, Alberto-Alonso, José Ramón, Montraveta, Montserrat, Torres-Peral, Ricardo, Navalon-Rubio, María, Navas-López, Víctor Manuel, and Martin de Carpi, Javier

Published
2021
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5. Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).

Author

Amil‐Dias, Jorge, Oliva, Salvatore, Papadopoulou, Alexandra, Thomson, Mike, Gutiérrez‐Junquera, Carolina, Kalach, Nicolas, Orel, Rok, Auth, Marcus Karl‐Heinz, Nijenhuis‐Hendriks, Danielle, Strisciuglio, Caterina, Bauraind, Olivia, Chong, Sonny, Ortega, Gloria Dominguez, Férnandez, Sonia Férnandez, Furman, Mark, Garcia‐Puig, Roger, Gottrand, Frederic, Homan, Matjaz, Huysentruyt, Koen, and Kostovski, Aco

Published
2024
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7. Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis

Author

Papadopoulou, Alexandra, primary, Amil‐Dias, Jorge, additional, Auth, Marcus Karl‐Heinz, additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Gupta, Sandeep K., additional, Gutiérrez‐Junquera, Carolina, additional, Orel, Rok, additional, Vieira, Mario C., additional, Zevit, Noam, additional, Atkins, Dan, additional, Bredenoord, Albert J., additional, Carneiro, Fatima, additional, Dellon, Evan S., additional, Gonsalves, Nirmala, additional, Menard‐Katcher, Calies, additional, Koletzko, Sibylle, additional, Liacouras, Chris, additional, Marderfeld, Luba, additional, Oliva, Salvatore, additional, Ohtsuka, Yoshikazu, additional, Rothenberg, Marc E., additional, Strauman, Alex, additional, Thapar, Nikhil, additional, Yang, Guan‐Yu, additional, and Furuta, Glenn T., additional

Published
2024
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8. Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real‐world efficacy from the EoE CONNECT registry

Author

Laserna‐Mendieta, Emilio J., Navarro, Pilar, Casabona‐Francés, Sergio, Savarino, Edoardo V., Amorena, Edurne, Pérez‐Martínez, Isabel, Guagnozzi, Danila, Blas‐Jhon, Leonardo, Betoré, Elena, Guardiola‐Arévalo, Antonio, Pellegatta, Gaia, Krarup, Anne Lund, Perello, Antonia, Barrio, Jesús, Gutiérrez‐Junquera, Carolina, Teruel Sánchez‐Vegazo, Carlos, Fernández‐Fernández, Sonia, Naves, Juan Enrique, Oliva, Salvatore, Rodríguez‐Oballe, Juan Armando, Carrión, Silvia, Espina, Silvia, Llorente Barrio, Mónica, Masiques‐Mas, Maria Lluisa, Dainese, Raffaella, Feo‐Ortega, Sara, Martín‐Dominguez, Verónica, Fernández‐Pacheco, Jennifer, Pérez‐Fernández, Maria Teresa, Ghisa, Matteo, Maniero, Daria, Nantes‐Castillejo, Óscar, Nicolay‐Maneru, Julia, Suárez, Adolfo, Maray, Iván, Llerena‐Castro, Ronald, Ortega‐Larrodé, Adriana, Alcedo, Javier, Granja Navacerrada, Alicia, Racca, Francesca, Santander, Cecilio, Arias, Ángel, and Lucendo, Alfredo J.

Abstract

Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses. To assess the effectiveness of topical corticosteroid therapy for EoE in real‐world practice. Cross‐sectional study analysis of the multicentre EoE CONNECT registry. Clinical remission was defined as a decrease of ≥50% in dysphagia symptom scores; histological remission was defined as a peak eosinophil count below 15 per high‐power field. The effectiveness in achieving clinico‐histological remission (CHR) was compared for the main tC formulations. Overall, data on 1456 prescriptions of tC in monotherapy used in 866 individual patients were assessed. Of those, 904 prescriptions with data on formulation were employed for the induction of remission; 234 reduced a previously effective dose for maintenance. Fluticasone propionate formulations dominated the first‐line treatment, while budesonide was more common in later therapies. A swallowed nasal drop suspension was the most common formulation of fluticasone propionate. Doses ≥0.8 mg/day provided a 65% CHR rate and were superior to lower doses. Oral viscous solution prepared by a pharmacist was the most common prescription of budesonide; 4 mg/day provided no benefit over 2 mg/day (CHR rated being 72% and 80%, respectively). A multivariate analysis revealed budesonide orodispersible tablets as the most effective therapy (OR 18.9, p< 0.001); use of higher doses (OR 4.3, p= 0.03) and lower symptom scores (OR 0.9, p= 0.01) were also determinants of effectiveness. Reduced symptom severity, use of high doses, and use of budesonide orodispersible tablets particularly were all independent predictors of tC effectiveness.

Published
2024
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9. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Kafritsa, Panayota, Brusa, Sandra, Campanozzi, Angelo, Romano, Claudio, Salvatore, Silvia, Kotzakioulafi, Evelina, Barrio, Josefa, Cilleruelo, Maria Luz, Juste, Mercedes, Gutiérrez-Junquera, Carolina, Trbojević, Tena, Ivković, Lana, Scarpato, Elena, Kolacek, Sanja, Jojkic-Pavkov, Danijela, Konjik, Vlatka, Živković, Nataša, Roman, Enriqueta, Kostovski, Aco, Zdraveska, Nikolina, Altamimi, Eyad, Papadopoulou, Alexandra, Karagiozoglou-Lampoudi, Thomai, Shamir, Raanan, Bar Lev, Michal Rozenfeld, Koleilat, Aziz, Mneimneh, Sirin, Bruzzese, Dario, Leis, Rosaura, and Staiano, Annamaria

Published
2018
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10. Correction to: Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicenter Spanish study

Author

Garcia-Romero, Ruth, de Zabarte Fernandez, José Miguel Martinez, Pujol-Muncunill, Gemma, Donat-Aliaga, Ester, Segarra-Cantón, Oscar, Irastorza-Terradillos, Iñaki, Medina-Benitez, Enrique, Ruiz-Hernández, Carlos José, Carrillo-Palau, Marta, Ros-Arnal, Ignacio, Rodriguez-Martínez, Alejandro, Escartin-Madurga, Laura, Gutiérrez-Junquera, Carolina, Vicente-Santamaría, Saioa, Rodriguez-Belvis, Marta Velasco, Fernández-Fernández, Sonia, Alberto-Alonso, José Ramón, Montraveta, Montserrat, Torres-Peral, Ricardo, Navalon-Rubio, María, Navas-López, Víctor Manuel, and de Carpi, Javier Martin

Published
2021
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11. Medical treatment of eosinophilic esophagitis

Author

Franciosi, James P, additional, Gordon, Morris, additional, Sinopoulou, Vassiliki, additional, Dellon, Evan S, additional, Gupta, Sandeep K, additional, Reed, Craig C, additional, Gutiérrez-Junquera, Carolina, additional, Venkatesh, Rajitha D, additional, Erwin, Elizabeth A, additional, Egiz, Abdullah, additional, Elleithy, Assem, additional, and Mougey, Edward B, additional

Published
2023
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14. Corrigendum to “Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry” [Digestive and Liver Disease Volume 55, Issue 3, March 2023, Pages 350–359]

Author

Laserna-Mendieta, Emilio José, primary, Navarro, Pilar, additional, Casabona-Francés, Sergio, additional, Savarino, Edoardo V, additional, Pérez-Martínez, Isabel, additional, Guagnozzi, Danila, additional, Barrio, Jesús, additional, Perello, Antonia, additional, Guardiola-Arévalo, Antonio, additional, Betoré-Glaria, María Elena, additional, Blas-Jhon, Leonardo, additional, Racca, Francesca, additional, Krarup, Anne Lund, additional, Gutiérrez-Junquera, Carolina, additional, Fernández-Fernández, Sonia, additional, De la Riva, Susana, additional, Naves, Juan E, additional, Carrión, Silvia, additional, García-Morales, Natalia, additional, Roales, Valentín, additional, Rodríguez-Oballe, Juan Armando, additional, Dainese, Raffaella, additional, Rodríguez-Sánchez, Alba, additional, Masiques-Mas, María Lluisa, additional, Feo-Ortega, Sara, additional, Ghisa, Matteo, additional, Maniero, Daria, additional, Suarez, Adolfo, additional, Llerena-Castro, Ronald, additional, Gil-Simón, Paula, additional, de la Peña-Negro, Luisa, additional, Granja-Navacerrada, Alicia, additional, Alcedo, Javier, additional, Hurtado de Mendoza-Guena, Lonore, additional, Pellegatta, Gaia, additional, Pérez-Fernández, María Teresa, additional, Santander, Cecilio, additional, Tamarit-Sebastián, Sonsoles, additional, Arias, Ángel, additional, and Lucendo, Alfredo J., additional

Published
2023
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15. Medical treatment of eosinophilic esophagitis

Author

Franciosi, James P, Gordon, Morris, Sinopoulou, Vassiliki, Dellon, Evan S, Gupta, Sandeep K, Reed, Craig C, Gutiérrez-Junquera, Carolina, Venkatesh, Rajitha D, Erwin, Elizabeth A, Egiz, Abdullah Mohammed abousaleh ma, Elleithy, Assem, Mougey, Edward B, Franciosi, James P, Gordon, Morris, Sinopoulou, Vassiliki, Dellon, Evan S, Gupta, Sandeep K, Reed, Craig C, Gutiérrez-Junquera, Carolina, Venkatesh, Rajitha D, Erwin, Elizabeth A, Egiz, Abdullah Mohammed abousaleh ma, Elleithy, Assem, and Mougey, Edward B

Published
2023

16. Recommendations for the diagnosis and practical management of paediatric eosinophilic oesophagitis

Author

Alonso Vicente, Carmen, Álvarez Beltrán, Marina, Barrio Torres, Josefa, Barros García, Patricia, Colomé Rivero, Gemma, Javier Eizaguirre Arocena, Francisco, Fernández Caamaño, Beatriz, Orden Izquierdo, Enrique la, Leis Trabazo, Rosaura, Lorenzo Garrido, Helena, Medina Benítez, Enrique, Montraveta Querol, Montserrat, Vecino López, Raquel, Gutiérrez Junquera, Carolina, Fernández Fernández, Sonia, Domínguez-Ortega, Gloria, Vila Miravet, Víctor, García Puig, Roger, García Romero, Ruth, Fernández de Valderrama, Ana, and Andradas Rivas, Rebeca

Published
2020
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17. Recomendaciones para el diagnóstico y manejo práctico de la esofagitis eosinofílica pediátrica

Author

Alonso Vicente, Carmen, Álvarez Beltrán, Marina, Barrio Torres, Josefa, Barros García, Patricia, Colomé Rivero, Gemma, Javier Eizaguirre Arocena, Francisco, Fernández Caamaño, Beatriz, Orden Izquierdo, Enrique la, Leis Trabazo, Rosaura, Lorenzo Garrido, Helena, Medina Benítez, Enrique, Montraveta Querol, Montserrat, Vecino López, Raquel, Gutiérrez Junquera, Carolina, Fernández Fernández, Sonia, Domínguez-Ortega, Gloria, Vila Miravet, Víctor, García Puig, Roger, García Romero, Ruth, Fernández de Valderrama, Ana, and Andradas Rivas, Rebeca

Published
2020
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19. Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry

Author

Laserna-Mendieta, Emilio José, primary, Navarro, Pilar, additional, Casabona-Francés, Sergio, additional, Savarino, Edoardo V, additional, Pérez-Martínez, Isabel, additional, Guagnozzi, Danila, additional, Barrio, Jesús, additional, Perello, Antonia, additional, Guardiola-Arévalo, Antonio, additional, Betoré-Glaria, María Elena, additional, Blas-Jhon, Leonardo, additional, Racca, Francesca, additional, Krarup, Anne Lund, additional, Gutiérrez-Junquera, Carolina, additional, Fernández-Fernández, Sonia, additional, la Riva, Susana De, additional, Naves, Juan E, additional, Carrión, Silvia, additional, García-Morales, Natalia, additional, Roales, Valentín, additional, Rodríguez-Oballe, Juan Armando, additional, Dainese, Raffaella, additional, Rodríguez-Sánchez, Alba, additional, Masiques-Mas, María Lluisa, additional, Feo-Ortega, Sara, additional, Ghisa, Matteo, additional, Maniero, Daria, additional, Suarez, Adolfo, additional, Llerena-Castro, Ronald, additional, Gil-Simón, Paula, additional, Peña-Negro, Luisa de la, additional, Granja-Navacerrada, Alicia, additional, Alcedo, Javier, additional, Hurtado de Mendoza-Guena, Lonore, additional, Pellegatta, Gaia, additional, Pérez-Fernández, María Teresa, additional, Santander, Cecilio, additional, Tamarit-Sebastián, Sonsoles, additional, Arias, Ángel, additional, and Lucendo, Alfredo J, additional

Published
2022
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22. Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry.

Author

Laserna-Mendieta, Emilio José, Navarro, Pilar, Casabona-Francés, Sergio, Savarino, Edoardo V, Pérez-Martínez, Isabel, Guagnozzi, Danila, Barrio, Jesús, Perello, Antonia, Guardiola-Arévalo, Antonio, Betoré-Glaria, María Elena, Blas-Jhon, Leonardo, Racca, Francesca, Krarup, Anne Lund, Gutiérrez-Junquera, Carolina, Fernández-Fernández, Sonia, la Riva, Susana De, Naves, Juan E, Carrión, Silvia, García-Morales, Natalia, and Roales, Valentín

Abstract

Direct comparisons of childhood- and adulthood-onset eosinophilic esophagitis (EoE) are scarce. To compare disease characteristics, endoscopic and histological features, allergic concomitances and therapeutic choices across ages. Cross-sectional analysis of the EoE CONNECT registry. The adulthood-onset cohort (those diagnosed at ≥18y) comprised 1044 patients and the childhood‐onset cohort (patients diagnosed at <18 y), 254. Vomiting, nausea, chest and abdominal pain, weight loss, slow eating and food aversion were significantly more frequent in children; dysphagia, food bolus impaction and heartburn predominated in adults. A family history of EoE was present in 16% of pediatric and 8.2% of adult patients (p <0.001). Concomitant atopic diseases did not vary across ages. Median±IQR diagnostic delay (years) from symptom onset was higher in adults (2.7 ± 6.1) than in children (1 ± 2.1; p <0.001). Esophageal strictures and rings predominated in adults (p <0.001), who underwent esophageal dilation more commonly (p = 0.011). Inflammatory EoE phenotypes were more common in children (p = 0.001), who also presented higher eosinophil counts in biopsies (p = 0.015) and EREFS scores (p = 0.017). Despite PPI predominating as initial therapy in all cohorts, dietary therapy and swallowed topical corticosteroids were more frequently prescribed in children (p <0.001). Childhood‐onset EoE has differential characteristics compared with adulthood-onset, but similar response to treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry

Author

Navarro, Pilar, primary, Laserna‐Mendieta, Emilio J, additional, Casabona, Sergio, additional, Savarino, Edoardo, additional, Pérez‐Fernández, María Teresa, additional, Ghisa, Matteo, additional, Pérez‐Martínez, Isabel, additional, Guagnozzi, Danila, additional, Perelló, Antonia, additional, Guardiola‐Arévalo, Antonio, additional, Racca, Francesca, additional, Betoré, Elena, additional, Blas‐Jhon, Leonardo, additional, Krarup, Anne Lund, additional, Martín‐Domínguez, Verónica, additional, Maniero, Daria, additional, Suárez, Adolfo, additional, Llerena‐Castro, Ronald, additional, de la Peña‐Negro, Luisa, additional, Navacerrada, Alicia Granja, additional, Pellegatta, Gaia, additional, Alcedo, Javier, additional, de Hurtado Mendoza‐Guena, Lonore, additional, Feo‐Ortega, Sara, additional, Barrio, Jesús, additional, Gutiérrez‐Junquera, Carolina, additional, Fernández‐Fernández, Sonia, additional, De la Riva, Susana, additional, E Navés, Juan, additional, Carrión, Silvia, additional, Ciriza de los Ríos, Constanza, additional, García‐Morales, Natalia, additional, Rodríguez‐Oballe, Juan Armando, additional, Dainese, Raffaela, additional, Rodríguez‐Sánchez, Alba, additional, Masiques‐Mas, María Lluisa, additional, Palomeque, María Teresa, additional, Santander, Cecilio, additional, Tamarit‐Sebastián, Sonsoles, additional, Arias, Ángel, additional, and Lucendo, Alfredo J, additional

Published
2022
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24. 960 BUDESONIDE ORAL SUSPENSION IS EFFECTIVE AND SAFE AS INDUCTION TREATMENT OF EOSINOPHILIC ESOPHAGITIS IN CHILDREN AND ADOLESCENTS: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INDUCTION PHASE OF A MULTICENTER PEDIATRIC TRIAL (PEDEOS-1)

Author

Lucendo, Alfredo J, Antunes, Henedina, Papadopoulou, Alexandra, Auth, Marcus K., Dutt, Shoma, Escher, Johanna C., van Wijk, Michiel P., Domínguez-Ortega, Gloria, Gutiérrez-Junquera, Carolina, Zevit, Noam, Zangen, Tsili, Trindade, Eunice, Fotoulaki, Maria, Dalgic, Buket, Lopes, Ana I., Feo-Ortega, Sara, Neiva, Filipa, Karagianni, Vassiliki-Maria -., Rogalidou, Maria, Hendriks, Danielle, Mussies, Carlijn, Ubierna, Nuria Puente, Espinheira, Maria Céu, Loreto, Helena, Vieth, Michael, Burrack, Sarah, Mueller, Ralph, Greinwald, Roland, Buderus, Stephan, and Amil-Dias, Jorge

Published
2024
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25. EoE CONNECT, the European Registry of Clinical, Environmental, and Genetic Determinants in Eosinophilic Esophagitis: rationale, design, and study protocol of a large-scale epidemiological study in Europe

Author

Lucendo, Alfredo J., primary, Santander, Cecilio, additional, Savarino, Edoardo, additional, Guagnozzi, Danila, additional, Pérez-Martínez, Isabel, additional, Perelló, Antonia, additional, Guardiola-Arévalo, Antonio, additional, Barrio, Jesús, additional, Elena Betoré-Glaria, María, additional, Gutiérrez-Junquera, Carolina, additional, Ciriza de los Ríos, Constanza, additional, Racca, Francesca, additional, Fernández-Fernández, Sonia, additional, Blas-Jhon, Leonardo, additional, Lund Krarup, Anne, additional, de la Riva, Susana, additional, Naves, Juan E., additional, Carrión, Silvia, additional, Rodríguez Oballe, Juan Armando, additional, García-Morales, Natalia, additional, Tamarit-Sebastián, Sonsoles, additional, Navarro, Pilar, additional, Arias, Ángel, additional, Laserna-Mendieta, Emilio J., additional, Casabona-Francés, Sergio, additional, Pérez-Fernández, Teresa, additional, Llerena Castro, Roland, additional, Ghisa, Matteo, additional, Manie, Daria, additional, Pellegatta, Gaia, additional, Suárez, Adolfo, additional, Alcedo, Javier, additional, Gil Simón, Paula, additional, Teresa Palomeque, María, additional, Asensio, Teresa, additional, Granja-Navacerrada, Alicia, additional, de Mendoza Guena, Lonore Hurtado, additional, Rodríguez Sánchez, Alba, additional, Masiques Mas, Lluïsa, additional, Dainese, Raffaella, additional, and Feo-Ortega, Sara, additional

Published
2022
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26. Proton pump inhibitor therapy in pediatric eosinophilic esophagitis: predictive factors and long-term step-down efficacy.

Author

Gutiérrez-Junquera, Carolina, Fernández-Fernández, Sonia, Domínguez-Ortega, Gloria, Vila Miravet, Víctor, García-Puig, Roger, La Orden-Izquierdo, Enrique, Peña Quintana, Luis, Barrio Torres, Josefa, Medina Benítez, Enrique, Leis, Rosaura, García-Romero, Ruth, Fernández de Valderrama, Ana, Vecino López, Raquel, Donado Palencia, Paloma, Beltrán, Marina Alvarez, Reyes-Domínguez, Ana Isabel, Colomé-Rivero, Gemma, Manchón, Silvia Rodríguez, Martinón, Nazareth, and Fernández-Caamaño, Beatriz

Published
2023
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28. Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn ' s Disease in Children: PRESENCE Study from SEGHNP

Author

Moriczi, Melinda, Pujol Muncunill, Gemma, Martín Masot, Rafael, Jiménez Treviño, Santiago, Segarra Cantón, Oscar, Ochoa Sangrador, Carlos, Peña Quintana, Luís, González Santana, Daniel, Rodríguez Martínez, Alejandro, Rosell Camps, Antonio, Armas, Honorio, Barrio, Josefa, González de Caldas, Rafael, Rodríguez Salas, Mónica, Balmaseda Serrano, Elena, Donat Aliaga, Ester, Bodas Pinedo, Andrés, Vaquero Sosa, Esther, Vecino López, Raquel, Solar Boga, Alfonso, Moreno Álvarez, Ana, Sánchez Sánchez, César, Tolín Hernani, Mar, Gutiérrez Junquera, Carolina, Martinón Torres, Nazareth, Leis Trabazo, María Rosaura, Eizaguirre, Francisco Javier, García Peris, Mónica, Medina Benítez, Enrique, Fernández Cebrián, Rafael, Fernández Caamaño, Beatriz, Vegas Álvarez, Ana María, Crespo Valderrábano, Laura, Alonso Vicente, Carmen, Rubio Santiago, Javier, Galera Martínez, Rafael, García Romero, Ruth, Ros Arnal, Ignacio, Fernández Cebrián, Santiago, Lorenzo Garrido, Helena, Viada Bris, Javier Francisco, Velasco Rodríguez-Belvís, Marta, Bartolomé Porro, Juan Manuel, Blanco Rodríguez, Miriam, Barros García, Patricia, Botija, Gonzalo, Chicano Marín, Francisco José, La Orden Izquierdo, Enrique, Crehuá Gaudiza, Elena, Navas López, Víctor Manuel, Martín de Carpi, Javier, and Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría

Subjects
Male, Crohn’s disease, medicine.medical_specialty, paediatric, Adolescent, humanos, adolescente, lcsh:TX341-641, Disease, calprotectin, Inflammatory bowel disease, Article, 03 medical and health sciences, Enteral Nutrition, 0302 clinical medicine, Crohn Disease, children, inflammatory bowel disease, Internal medicine, medicine, Humans, inducción de remisión, nutrición enteral, 030212 general & internal medicine, Child, Adverse effect, Retrospective Studies, Response rate (survey), Crohn's disease, Nutrition and Dietetics, business.industry, exclusive enteral nutrition, Remission Induction, estudios retrospectivos, medicine.disease, digestive system diseases, Parenteral nutrition, enfermedad de Crohn, Female, 030211 gastroenterology & hepatology, Observational study, Calprotectin, business, lcsh:Nutrition. Foods and food supply, Food Science
Abstract

Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn&acute, s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014&ndash, 2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 &plusmn, 2.5 years. The median EEN duration was 8 weeks (IQR 6.6&ndash, 8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn&rsquo, s Disease activity index [wPCDAI] &lt, 12.5). Faecal calprotectin (FC) levels (&mu, g/g) decreased significantly after EEN (830 [IQR 500&ndash, 1800] to 256 [IQR 120&ndash, 585] p &lt, 0.0001). Patients with wPCDAI &le, 57.5, FC &lt, 500 &mu, g/g, CRP &gt, 15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6&ndash, 8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn&rsquo, s disease regardless of the location of disease and disease activity.

Published
2020

29. Differences in Management of Eosinophilic Esophagitis in Europe: An Assessment of Current Practice

Author

Tourlamain, Gilles, primary, Garcia-Puig, Roger, additional, Gutiérrez-Junquera, Carolina, additional, Papadopoulou, Alexandra, additional, Roma, Eleftheria, additional, Kalach, Nicolas, additional, Oudshoorn, Johanna, additional, Sokollik, Christiane, additional, Karolewska-Bochenek, Kasia, additional, Oliva, Salvatore, additional, Strisciuglio, Caterina, additional, Bauraind, Olivia, additional, Auth, Marcus Karl-Heinz, additional, Thomson, Mike, additional, Otte, Sebastian, additional, Rok, Orel, additional, Dias, Jorge Amil, additional, Tzivinikos, Christos, additional, Urbonas, Vaidotas, additional, Kostovski, Aco, additional, Zevit, Noam, additional, and Velde, Saskia Vande, additional

Published
2020
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30. Mo1988 THE PEDIATRIC ENDOSCOPY PRACTICE IN EUROPE: PRELIMINARY RESULTS OF A WEB-BASED SURVEY ON BEHALF OF THE ENDOSCOPY SPECIAL INTEREST GROUP OF EUROPEAN SOCIETY OF GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION (ESPGHAN)

Author

Oliva, Salvatore, primary, Dias, Jorge A., additional, Alateeqi, Fadhel, additional, Bitar, Rana, additional, Bontems, Patrick, additional, Borrelli, Osvaldo, additional, Broekaert, Ilse, additional, Vandenplas, Yvan, additional, Navas-López, Victor, additional, Cadranel, Samy, additional, Cohen, Shlomi, additional, Cosgrove, Mike, additional, Angelis, Paola De, additional, Ridder, Lissy de, additional, Domínguez-Ortega, Gloria, additional, Saccomani, Marco Deganello, additional, Furlano, Raoul I., additional, Gottrand, Frederic, additional, Gutiérrez-Junquera, Carolina, additional, Kalach, Nicolas, additional, Kori, Michal, additional, Ledder, Oren, additional, Miele, Erasmo, additional, Norsa, Lorenzo, additional, Pienar, Corina, additional, Romano, Claudio, additional, Shaoul, Ron, additional, Alghamdi, Alghamdi a., additional, Tavares, Marta, additional, Thapar, Nikhil, additional, Tzivinikos, Christos, additional, Velde, Saskia Vande, additional, Strisciuglio, Caterina, additional, Viala, Jerome, additional, Zellos, Aglaia, additional, Zevit, Noam, additional, Zifman, Eyal, additional, and Thomson, Mike, additional

Published
2020
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31. Recomendaciones para el diagnóstico y manejo práctico de la esofagitis eosinofílica pediátrica

Author

Gutiérrez Junquera, Carolina, primary, Fernández Fernández, Sonia, additional, Domínguez-Ortega, Gloria, additional, Vila Miravet, Víctor, additional, García Puig, Roger, additional, García Romero, Ruth, additional, Fernández de Valderrama, Ana, additional, Andradas Rivas, Rebeca, additional, Alonso Vicente, Carmen, additional, Álvarez Beltrán, Marina, additional, Barrio Torres, Josefa, additional, Barros García, Patricia, additional, Colomé Rivero, Gemma, additional, Javier Eizaguirre Arocena, Francisco, additional, Fernández Caamaño, Beatriz, additional, Orden Izquierdo, Enrique la, additional, Leis Trabazo, Rosaura, additional, Lorenzo Garrido, Helena, additional, Medina Benítez, Enrique, additional, Montraveta Querol, Montserrat, additional, and Vecino López, Raquel, additional

Published
2020
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32. Recommendations for the diagnosis and practical management of paediatric eosinophilic oesophagitis

Author

Gutiérrez Junquera, Carolina, primary, Fernández Fernández, Sonia, additional, Domínguez-Ortega, Gloria, additional, Vila Miravet, Víctor, additional, García Puig, Roger, additional, García Romero, Ruth, additional, Fernández de Valderrama, Ana, additional, Andradas Rivas, Rebeca, additional, Alonso Vicente, Carmen, additional, Álvarez Beltrán, Marina, additional, Barrio Torres, Josefa, additional, Barros García, Patricia, additional, Colomé Rivero, Gemma, additional, Javier Eizaguirre Arocena, Francisco, additional, Fernández Caamaño, Beatriz, additional, Orden Izquierdo, Enrique la, additional, Leis Trabazo, Rosaura, additional, Lorenzo Garrido, Helena, additional, Medina Benítez, Enrique, additional, Montraveta Querol, Montserrat, additional, and Vecino López, Raquel, additional

Published
2020
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33. Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP

Author

Moriczi, Melinda, primary, Pujol-Muncunill, Gemma, additional, Martín-Masot, Rafael, additional, Jiménez Treviño, Santiago, additional, Segarra Cantón, Oscar, additional, Ochoa Sangrador, Carlos, additional, Peña Quintana, Luis, additional, González Santana, Daniel, additional, Rodríguez Martínez, Alejandro, additional, Rosell Camps, Antonio, additional, Armas, Honorio, additional, Barrio, Josefa, additional, González de Caldas, Rafael, additional, Rodríguez Salas, Mónica, additional, Balmaseda Serrano, Elena, additional, Donat Aliaga, Ester, additional, Bodas Pinedo, Andrés, additional, Vaquero Sosa, Esther, additional, Vecino López, Raquel, additional, Solar Boga, Alfonso, additional, Moreno Álvarez, Ana, additional, Sánchez Sánchez, César, additional, Tolín Hernani, Mar, additional, Gutiérrez Junquera, Carolina, additional, Martinón Torres, Nazareth, additional, Leis Trabazo, María Rosaura, additional, Eizaguirre, Francisco Javier, additional, García Peris, Mónica, additional, Medina Benítez, Enrique, additional, Fernández Caamaño, Beatriz, additional, Vegas Álvarez, Ana María, additional, Crespo Valderrábano, Laura, additional, Alonso Vicente, Carmen, additional, Rubio Santiago, Javier, additional, Galera-Martínez, Rafael, additional, García-Romero, Ruth, additional, Ros Arnal, Ignacio, additional, Fernández Cebrián, Santiago, additional, Lorenzo Garrido, Helena, additional, Viada Bris, Javier Francisco, additional, Velasco Rodríguez-Belvis, Marta, additional, Bartolomé Porro, Juan Manuel, additional, Blanco Rodríguez, Miriam, additional, Barros García, Patricia, additional, Botija, Gonzalo, additional, Chicano Marín, Francisco José, additional, La Orden Izquierdo, Enrique, additional, Crehuá-Gaudiza, Elena, additional, Navas-López, Víctor Manuel, additional, and Martín-de-Carpi, Javier, additional

Published
2020
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34. Rising trend in p​ediatric eosinophilic esophagitis incidence in Spain: Results of a prospective study 2014–16.

Author

La Orden Izquierdo, Enrique, Mahillo‐Fernández, Ignacio, Fernández Fernández, Sonia, Barrio Torres, Josefa, Román Riechmann, Enriqueta, Gutiérrez Junquera, Carolina, Santos, Alexandra, Cilleruelo Pascual, ML, Rayo Fernández, AI, Martínez Escribano, B, Botija Arcos, G, Barrio Merino, A, Urruzuno Tellería, P, Medina Benítez, E, Salcedo Lobato, E, Grande Herrero, L, Miranda Cid, C, Rodrigo García, G, Herrero Álvarez, M, and Carabaño Aguado, I

Subjects
LONGITUDINAL method, AIR pollutants, SYMPTOMS, DIAGNOSIS, EOSINOPHILIC esophagitis, MEDICAL consultation, DEGLUTITION disorders
Abstract

Objectives: The rate of eosinophilic esophagitis (EoE) diagnosis is increasing. This study aims to determine the incidence of EoE in the pediatric population residing in the southwestern Madrid and to analyze whether absolute monthly pollen counts, modified or not by the principal atmospheric pollutants, are associated with it. Methods: A cross‐sectional study on prospectively recruited patients was designed to calculate the incidence of EoE in children aged under 15 years who were diagnosed between September 2014 and August 2016 in twelve hospitals. We collected demographic and symptoms data, date of onset of symptoms, date of medical consultation, and date of endoscopic diagnosis of each included patient. Relative risk estimation was performed to assess the association between the incidence of diagnosis and monthly pollen counts and levels of atmospheric pollutants. All these models were adjusted for the number of total patients that underwent endoscopy at first time. Results: One hundred forty‐eight patients were included. The most frequent symptoms were abdominal pain [42.57%], dysphagia [42.57%], and impaction [39%–86%]. The median overall monthly incidence was 1.13 [interquartile rank: 0.97–1.43] cases/100,000 children, and the annual mean was 15.2. The overall analysis of the relationship between incidence and absolute monthly counts, corrected for the number of first‐time endoscopies performed, revealed no statistically significant association with pollen and air pollutants. There was a higher frequency of diagnosis during the pollination period of Cupressaceae [relative risk 1.647; 95% CI (1.192–2.276) p <.002] and during February and November (relative risk 1.67; p <.01). Conclusions: This study confirms the high incidence of eosinophilic esophagitis and also suggests a period of higher incidence of diagnosis in the months of February and November as well as in the period of high pollination of Cupressaceae. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Pediatric parenteral nutrition: Clinical practice guidelines from the Spanish Society of Parenteral and Enteral Nutrition (SENPE), the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition (SEGHNP) and the Spanish Society of Hospital Pharmacy (SEFH)

Author

Pedrón, Consuelo, Cuervas-Mons Vendrell, Margarita, Galera Martínez, Rafael, Gómez López, Lilianne, Gomis Muñoz, Pilar, Irastorza Terradillos, Iñaki, Martínez Costa, Cecilia, Moreno Villares, José Manuel, Pérez-Portabella Maristany, Cleofé, Pozas del Río, M. Teresa, Redecillas Ferreiro, Susana E., Prieto Bozano, Gerardo, Balmaseda Serrano, Elena, Cañedo Villarroya, Elvira, Gutiérrez Junquera, Carolina, Morais López, Ana, Meavilla Olivas, Silvia, Navas López, Víctor Manuel, Rubio Murillo, María, Vives Piñera, Inmaculada, Vidal Casariego, Alfonso, Cuerda Compés, Cristina de la, Matía Martín, Pilar, Frías Soriano, Laura, Ruiz López, M. Dolores, Vaquerizo Alonso, Clara, and UAM. Departamento de Pediatría

Subjects
Medicina, Child, Newborn, Parenteral nutrition, Standardization
Abstract

Introduction: Parenteral nutrition (PN) in childhood is a treatment whose characteristics are highly variable depending on the age and pathology of the patient. Material and methods: The Standardization and Protocols Group of the Spanish Society for Parenteral and Enteral Nutrition (SENPE) is an interdisciplinary group formed by members of the SENPE, the Spanish Society of Gastroenterology, Hepatology and Pediatric Nutrition (SEGHNP) and the Spanish Society of Hospital Pharmacy (SEFH) that intends to update this issue. For this, a detailed review of the literature has been carried out, looking for the evidences that allow us to elaborate a Clinical Practice Guide following the criteria of the Oxford Center for Evidence-Based Medicine. Results: This manuscript summarizes the recommendations regarding indications, access routes, requirements, modifications in special situations, components of the mixtures, prescription and standardization, preparation, administration, monitoring, complications and home NP. The complete document is published as a monographic number. Conclusions: This guide is intended to support the prescription of pediatric PN. It provides the basis for rational decisions in the context of the existing evidence. No guidelines can take into account all of the often compelling individual clinical circumstances., Introducción: la nutrición parenteral (NP) en la infancia es un tratamiento cuyas características son muy variables en función de la edad y la patología que presente el paciente. Material y métodos: el grupo de Estandarización y Protocolos de la Sociedad Española de Nutrición Parenteral y Enteral (SENPE) es un grupo interdisciplinar formado por miembros de la SENPE, Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP) y Sociedad Española de Farmacia Hospitalaria (SEFH) que pretende poner al día este tema. Para ello, se ha realizado una revisión pormenorizada de la literatura buscando las evidencias que nos permiten elaborar una Guía de Práctica Clínica siguiendo los criterios del Oxford Centre for Evidence-Based Medicine. Resultados: este manuscrito expone de forma resumida las recomendaciones en cuanto a indicaciones, vías de acceso, requerimientos, modificaciones en situaciones especiales, componentes de las mezclas, prescripción y estandarización, preparación, administración, monitorización, complicaciones y NP domiciliaria. El documento completo se publica como número monográfico. Conclusiones: esta guía pretende servir de apoyo para la prescripción de la NP pediátrica. Constituye la base para tomar decisiones en el contexto de la evidencia existente. Ninguna guía puede tener en cuenta todas las circunstancias clínicas individuales

Published
2017

37. Distribution of eosinophils in the gastrointestinal tract of children with no organic disease.

Author

Koutri, Eleni, Patereli, Amalia, Noni, Maria, Gutiérrez-Junquera, Carolina, González-Lois, Carmen, Oliva, Salvatore, Giordano, Carla, Stefanaki, Kaliopi, and Papadopoulou, Alexandra

Subjects
GASTROINTESTINAL system, GASTROINTESTINAL mucosa, SIGMOID colon, COLON (Anatomy), CHILDREN'S hospitals
Abstract

Background This study aimed to assess the eosinophil (eos) density of the mucosa of the gastrointestinal (GI) tract in children undergoing endoscopic procedures following an extensive workup, without diagnosis of an organic disease. Methods Biopsies from GI endoscopies performed at 3 major children's hospitals (Athens, Madrid and Rome), between January 2012 and June 2018, were evaluated by a single pathologist in each center. Peak eos counts were expressed /high power field and /mm². Other histological abnormalities were also reported. Results A total of 111 children (median age 11 years; 48 boys) underwent upper endoscopy (333 biopsies), while 44 (median age 12; 25 boys) underwent ileocolonoscopy (262 biopsies). The median (interquartile range) eos/mm2 were as follows: esophagus 0 (0-0); stomach 0 (0-3); duodenum 22 (13-29); ileum 29 (19-46); cecum 39 (25-71); ascending colon 24 (20-41); transverse colon 27 (21-57); descending colon 21 (13-27); sigmoid colon 22 (13-30); and rectum 10 (6-22). Geographical variations in GI tissue eos counts were found amongst the participating centers, but the causative factors need further evaluation. Functional GI disorders according to the Rome IV criteria were diagnosed in 73 children (37 boys, median age 13 years). No differences were found between children with or without functional GI disorder diagnosis, with regard to eos density in the GI tract. Conclusion The reported peak counts of GI tissue eos in children with no organic diseases provide normative values that may be useful in the evaluation of children with GI symptoms suggestive of eosinophilic GI disorders. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe

Author

Scarpato, Elena, primary, Kolacek, Sanja, additional, Jojkic-Pavkov, Danijela, additional, Konjik, Vlatka, additional, Živković, Nataša, additional, Roman, Enriqueta, additional, Kostovski, Aco, additional, Zdraveska, Nikolina, additional, Altamimi, Eyad, additional, Papadopoulou, Alexandra, additional, Karagiozoglou-Lampoudi, Thomai, additional, Shamir, Raanan, additional, Bar Lev, Michal Rozenfeld, additional, Koleilat, Aziz, additional, Mneimneh, Sirin, additional, Bruzzese, Dario, additional, Leis, Rosaura, additional, Staiano, Annamaria, additional, Kafritsa, Panayota, additional, Brusa, Sandra, additional, Campanozzi, Angelo, additional, Romano, Claudio, additional, Salvatore, Silvia, additional, Kotzakioulafi, Evelina, additional, Barrio, Josefa, additional, Cilleruelo, Maria Luz, additional, Juste, Mercedes, additional, Gutiérrez-Junquera, Carolina, additional, Trbojević, Tena, additional, and Ivković, Lana, additional

Published
2018
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41. CYP2C19and STAT6Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis

Author

Mougey, Edward B., Williams, Andre, Coyne, Ashlan J. Kunz, Gutiérrez-Junquera, Carolina, Fernández-Fernández, Sonia, Cilleruelo, Maria Luz, Rayo, Ana, Echeverría, Luis, Román, Enriqueta, González Lois, Carmen, Chao, Montserrat, Al-Atrash, Hadeel, Lima, John J., and Franciosi, James P.

Abstract

Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic esophagitis (EoE); however, only 30% to 60% of patients respond. Common genetic variants in CYP2C19and STAT6associate with PPI plasma concentration and magnitude of inflammatory response, respectively. Our objective was to determine if genetic variation in the genes for CYP2C19and STAT6influence differentiation between PPI responsive esophageal eosinophilia versus PPI nonresponsive EoE (PPI-REE, PPI-nonresponsive EoE). Genomic DNA was isolated from 92 esophageal tissue biopsies collected from participants of a prospective clinical trial of high-dose PPI therapy for esophageal eosinophilia in children. Of the 92 patients examined, 57 (62%) were PPI-REE and 35 (38%) were PPI-nonresponsive EoE. Forty-six of the 92 patients were further characterized by pH probe monitoring; there was no association between reflux index and carriage of CYP2C19*17(P= 0.35). In children who received a PPI dose between =1.54 and ?2.05 mg/kg/day, binary logistic regression modeling showed that carriage of CYP2C19*17associated with PPI-nonresponsive EoE (odds ratio (OR) [95% confidence interval (CI)] = 7.71 [1.21, 49.11], P= 0.031). Carriage of STAT6allelic variant rs1059513 predicts PPI-REE (OR [95% CI] = 6.16 [1.44, 26.4], P= 0.028), whereas carriage of STAT6rs324011 synergizes with CYP2C19*17to predict PPI-nonresponsive EoE (rs324011 OR [95% CI] = 5.56 [1.33, 20.72], P= 0.022; CYP2C19*17OR [95% CI] = 8.19[1.42, 50.57], P= 0.023). Common variants in CYP2C19and STAT6associate with a PPI-nonresponsive EoE outcome of PPI therapy for esophageal eosinophilia suggesting that response rates may be improved by adopting a genotype-guided approach to PPI dosing.

Published
2019
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42. Gastroenteritis Aguda en Niños Hospitalizados (2005-2010): Análisis Epidemiológico, Microbiológico y Clínico

Author

Castillo Serrano, Ana, Plaza Almeida, Josefa, García González, Verónica, García Mialdea, Olga, Gutiérrez Junquera, Carolina, and Sainz de Baranda Camino, Caridad

Subjects
Rotavirus infections, Niño, Infecciones por Rotavirus, Child, Gastroenteritis
Abstract

Objetivo: El objetivo principal es analizar las características clínicas, epidemiológicas y microbiológicas de los pacientes ingresados con gastroenteritis aguda (GEA) en el Complejo Hospitalario Universitario de Albacete. Como objetivo secundario se pretende analizar la prevalencia de población vacunada a partir de la introducción de la vacuna frente a rotavirus a finales de 2006 y si existe algún cambio en el patrón epidemiológico. Diseño: Se estudiaron los pacientes menores de 5 años ingresados en el Complejo Hospitalario Universitario de Albacete entre octubre de 2004 y abril de 2010. Mediciones principales: Se recogieron datos demográficos, epidemiológicos y clínicos en todos los pacientes ingresados por gastroenteritis. Resultados: Los ingresos por GEA suponen un 7,8-15,0% del total de ingresos anuales de niños menores de 5 años. La edad media de los ingresados fue de 14 meses. La etiología fue vírica en el 65% de los casos. Rotavirus es el germen más frecuentemente aislado, predominando los serotipos G9 y G1. Tras la introducción de la vacuna, se registra una disminución del 79% de los ingresos secundarios a rotavirus. Conclusiones: Tendencia decreciente en el número de ingresos por GEA en menores de 5 años, con predominio de la etiología vírica a expensas de la infección por rotavirus. Utilidad del score de gravedad como predictor de etiología. Reducción significativa del número de ingresos secundarios a rotavirus tras la introducción de la vacuna en 2006, siendo imposible determinar con nuestro estudio si la vacunación es el único factor determinante de este fenómeno. Importante porcentaje de pacientes sin diagnóstico microbiológico con las detecciones empleadas de rutina en nuestra área de salud. Objective: The main objective is to analyse the clinical, epidemiological and microbiological characteristics of patients hospitalised with acute gastroenteritis (AG) in the University of Albecete Hospital Complex. The secondary objective is to determine the prevalence in the vaccinated population after the introduction of the rotavirus vaccine at the end of 2006 and if there is any change in the epidemiological pattern. Design: Patients aged under 5 years admitted to the Albacete University Hospital Complex between October 2004 and April 2010 were studied. Main measurements: Demographic, epidemiological and clinical data were collected for all patients admitted for gastroenteritis. Results: Children hospitalised for AG represent 7.8-15.0% of the total annual hospitalisations of children under the age 5 years. The mean age of the children was 14 months. The aetiology was viral in 65% of patients. The rotavirus was the most commonly isolated virus, G9 and G1 being the predominant serotypes. After the introduction of the vaccine a 79% decrease in hospitalisations secondary to a rotavirus infection was reported. Conclusions: There is a decreasing trend in the number of hospitalisations due to AG in children under 5 years. The AG is predominantly of viral aetiology mainly retrovirus. Usefulness of the severity score as a predictor of aetiology. Significant reduction in the number of admittances secondary to rotavirus after the introduction of the vaccine in 2006. In our study it was imposible to determine if vaccination is the only determining factor. High percentage of patients without microbiological diagnosis with the detection tests routinely used in our health area.

Published
2011

43. Documento de consenso SENPE/SEGHNP/ANECIPN/SECP sobre vías de acceso en nutrición enteral pediátrica

Author

Pedrón, Consuelo, Martínez-Costa, Cecilia, Navas-López, Víctor Manuel, Gómez-López, Lilianne, Redecillas-Ferrero, S., Moreno Villarés, José Manuel, Benlloch-Sánchez, C., Blasco-Alonso, Javier, García-Alcolea, B., Gómez-Fernández, B., Ladero-Morales, M., Moráis López, Ana B., Rosell-Camps, Antonio, Ashbaugh Enguídanos, R. A., Barco Gálvez, A., Bautista-Casasnovas, Adolfo L., Díaz Martín, Juan José, Frías Soriano, L., García Molina, Pablo, Gutiérrez Junquera, Carolina, Juste Ruiz, M., Lama More, Rosa Angélica, Marugán de Miguelsanz, J. M., Ollero Fresno, J. C., Poveda Jovellar, O., Sierra Salinas, Carlos, Unda Freire, A., and UAM. Departamento de Pediatría

Subjects
Gastrostomy, Medicina, Enteral access, Enteral nutrition, Newborn, Children
Abstract

Standardization of clinical procedures has become a desirable objective in contemporary medical practice. To this effect, the Spanish Society of Parenteral and Enteral Nutrition (SENPE) has endeavoured to create clinical practice guidelines and/or documents of consensus as well as quality standards in artificial nutrition. As a result, the SENPE’s Standardization Team has put together the “Document of Consensus in Enteral Access for Paediatric Nutritional Support” supported by the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition (SEGHNP), the National Association of Pediatric and Neonatal Intensive Care Nursery (ANECIPN), and the Spanish Society of Pediatric Surgery (SECP). The present publication is a reduced version of our work; the complete document will be published as a monographic issue. It analyzes enteral access options in the pediatric patient, reviews the levels of evidence and provides the team-members’ experience. Similarly, it details general and specific indications for pediatric enteral support, current techniques, care guidelines, methods of administration and complications of each enteral access. The data published by the American Society for Parenteral and Enteral Nutrition (ASPEN) and several European Societies has also been incorporated, La estandarización de procedimientos clínicos se ha convertido en un objetivo deseable en la práctica médica actual. La Sociedad Española de Nutrición Parenteral y Enteral (SENPE) está haciendo un considerable esfuerzo para desarrollar guías clínicas y/o documentos de consenso así como marcadores de calidad en nutrición artificial. Como fruto de ese esfuerzo el Grupo de Estandarización de SENPE ha elaborado un Documento de Consenso sobre Vías de Acceso en Nutrición Enteral Pediátrica, avalado también por la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), la Asociación Nacional de Enfermería de Cuidados Inten- sivos Pediátricos y Neonatales (ANECIPN) y la Sociedad Española de Cirugía Pediátrica (SECP). Esta publicación es una síntesis del documento consensuado que ha incluido el estudio en profundidad del acceso enteral pediátrico, la revisión de los niveles de evidencia y la experiencia de los componentes del Grupo. Se han considerado también los datos publicados por la American Society for Parenteral and Enteral Nutrition (ASPEN) y por diversas sociedades europeas. El texto completo se publicará como un número monográfico. En este trabajo se detallan las indicaciones generales y específicas de la nutrición enteral pediátrica, las técnicas, los cuidados generales y específicos, el modo de administración y las complicaciones de las diversas vías de acceso

Published
2011

44. Estudio del tiempo de tránsito cólico en niños con estreñimiento crónico idiopático

Author

Gutiérrez Junquera, Carolina and Marco Macián, Alfredo

Subjects
Gastroenterología y hepatología, Pediatría
Abstract

Introducción: El estreñimiento es un síntoma frecuente en la práctica clínica pediátrica, cuya fisiopatología no es del todo conocida. Objetivos: Determinar los patrones de normalidad de tiempo de tránsito cólico segmentario y total y de las variables de funcionalidad anorrectal en la infancia. Determinar la existencia de alteraciones de la motilidad cólica y anorrectal en niños con estreñimiento crónico idiopático. Población y método: Se han estudiado 30 niños en el grupo control y 38 niños con estreñimiento crónico idiopático, con edades comprendidas entre 2 y 14 años. Se realiazó encuesta de hábito defecatorio y cuestionario de consumo alimentario. El tiempo de tránsito cólico segmentario y total se estimó mediante la técnica de administración de marcadores radiopacos múltiples durante seis días con realización de una sóla radiografía de abdomen al séptimo día. Para el estudio de la función anorrectal se practicó manometría anorrectal mediante sonda de Arhan. Resultados: Los límites superiores de normalidad para los distintos tiempos de tránsito cólico estimados son: 19 horas para colon derecho e izquierdo, 32 horas para rectosigma y 45,7 horas para la totalidad del colon. El tiempo de tránsito cólico muestra una asociación inversa significativa con la frecuencia semanal de deposiciones, no observándose relación con el sexo ni con la edad. La mitad de los niños con estreñimiento crónico idiopático presentan valores de tránsito cólico dentro de la normalidad, el 37% retraso de tránsito en colon izquierdo y rectosigma y el 13% retraso global en todos los segmentos. Los niños estreñidos con tiempo de tránsito cólico prolongado tienen las siguientes características clínicas diferenciales: edades de inicio del estreñimiento más precoz, mayor frecuencia de antecedentes familiares de estreñimiento y masa abdominal palpable en la exploración física y mayor número de episodios de encopresis nocturna. Los niños con estreñimiento crónico idiopático muestran una presión en esfínter anal externo y canal anal inferior a los controles. Por el contrario, el umbral para desencadenar el reflejo inhibitorio del ano es superior en pacientes estreñidos, exhibiendo también mayor frecuencia de contracción paradójica del ano. Los niños estreñidos con retraso de tránsito en colon izquierdo y rectosigma presentan más frecuentemente contracción paradójica del ano que aquellos con tránsito normal. No hemos identificado dinámica anormal de la defecación en ninguno de los casos con inercia cólica. Conclusiones: La estimación del tiempo de tránsito cólico constituye una técnica simple y no invasiva que permite clasificar los pacientescon estreñimiento. Los pacientes con inercia cólica pueden constituir la manifestación de una disfunción global dela motilidad. Los niños esteñidos con retraso en colon distal presentan más frecuentemente alteraciones funcionales en la manometría anorrectal.

Published
1998

47. Estudio del tiempo de tránsito cólico en niños con estreñimiento crónico idiopático

Author

Marco Macián, Alfredo, Gutiérrez Junquera, Carolina, Marco Macián, Alfredo, and Gutiérrez Junquera, Carolina

Abstract

Introducción: El estreñimiento es un síntoma frecuente en la práctica clínica pediátrica, cuya fisiopatología no es del todo conocida. Objetivos: Determinar los patrones de normalidad de tiempo de tránsito cólico segmentario y total y de las variables de funcionalidad anorrectal en la infancia. Determinar la existencia de alteraciones de la motilidad cólica y anorrectal en niños con estreñimiento crónico idiopático. Población y método: Se han estudiado 30 niños en el grupo control y 38 niños con estreñimiento crónico idiopático, con edades comprendidas entre 2 y 14 años. Se realiazó encuesta de hábito defecatorio y cuestionario de consumo alimentario. El tiempo de tránsito cólico segmentario y total se estimó mediante la técnica de administración de marcadores radiopacos múltiples durante seis días con realización de una sóla radiografía de abdomen al séptimo día. Para el estudio de la función anorrectal se practicó manometría anorrectal mediante sonda de Arhan. Resultados: Los límites superiores de normalidad para los distintos tiempos de tránsito cólico estimados son: 19 horas para colon derecho e izquierdo, 32 horas para rectosigma y 45,7 horas para la totalidad del colon. El tiempo de tránsito cólico muestra una asociación inversa significativa con la frecuencia semanal de deposiciones, no observándose relación con el sexo ni con la edad. La mitad de los niños con estreñimiento crónico idiopático presentan valores de tránsito cólico dentro de la normalidad, el 37% retraso de tránsito en colon izquierdo y rectosigma y el 13% retraso global en todos los segmentos. Los niños estreñidos con tiempo de tránsito cólico prolongado tienen las siguientes características clínicas diferenciales: edades de inicio del estreñimiento más precoz, mayor frecuencia de antecedentes familiares de estreñimiento y masa abdominal palpable en la exploración física y mayor número de episodios de encopresis nocturna. Los niños con estreñimiento crónico idiopático muestran una presión en e

Published
2003

50. Esofagitis eosinofílica en el suroeste de Madrid ¿Existe un patrón geográfico-estacional oculto?

Author

La Orden Izquierdo, Enrique, Gutiérrez Junquera, Carolina (dir.), Mahíllo Fernández, Ignacio (dir.), Román Riechmann, Enriqueta (dir.), UAM. Departamento de Pediatría, Gutiérrez Junquera, Carolina, Mahíllo Fernández, Ignacio, and Román Riechmann, Enriqueta

Subjects
Medicina, Esofagitis - Tesis doctorales
Abstract

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Pediatría. Fecha de lectura: 29-09-2017

Published
2018

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